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64. PH plus STEM CELLS (SCS) IN CHRONIC MYELOID LEUKEMIA (CML): TO ERADICATE OR NOT TO ERADICATE, THIS IS THE QUESTION

Author

Pungolino, E, D'Adda, M, Trojani, A, Perego, A, Elena, C, Iurlo, A, Malato, S, Turrini, M, De Canal, G, Borin, L, Bossi, L, Caramella, M, Artale, S, Spina, F, Latargia, M, Anghilieri, M, Spedini, P, Carraro, M, Di Camillo, B, Gramegna, D, Pioltelli, M, Rossi, G, Morra, E, Cairoli, R, Pungolino E, D'adda M, Trojani A, Perego A, Elena C, Iurlo A, Malato S, Turrini M, De Canal G, Borin L, Bossi LE, Caramella M, Artale S, Spina F, Latargia ML, Anghilieri M, Spedini P, Carraro MC, Di Camillo B, Gramegna D, Pioltelli ML, Rossi G, Morra E, Cairoli R, Pungolino, E, D'Adda, M, Trojani, A, Perego, A, Elena, C, Iurlo, A, Malato, S, Turrini, M, De Canal, G, Borin, L, Bossi, L, Caramella, M, Artale, S, Spina, F, Latargia, M, Anghilieri, M, Spedini, P, Carraro, M, Di Camillo, B, Gramegna, D, Pioltelli, M, Rossi, G, Morra, E, Cairoli, R, Pungolino E, D'adda M, Trojani A, Perego A, Elena C, Iurlo A, Malato S, Turrini M, De Canal G, Borin L, Bossi LE, Caramella M, Artale S, Spina F, Latargia ML, Anghilieri M, Spedini P, Carraro MC, Di Camillo B, Gramegna D, Pioltelli ML, Rossi G, Morra E, and Cairoli R

Published
2019

65. IDENTIFICAZIONE DI MIRNA E GENI TARGET NELL’ANALISI TRASCRITTOMICA DELLE CELLULE CD34+/LIN- DI PAZIENTI CON LEUCEMIA MIELOIDE CRONICA IN FASE CRONICA DOPO 12 MESI DI TERAPIA CON NILOTINIB

Author

Trojani, A, Pungolino, E, Dal Molin, A, Bossi, L, Rossi, G, D'Adda, M, Perego, A, Elena, C, Turrini, M, Borin, L, Bucelli, C, Malato, S, Carraro, M, Spina, F, Latargia, M, Artale, S, Spedini, P, Anghilieri, M, Di Camillo, B, Baruzzo, G, De Canal, G, Iurlo, A, Morra, E, Cairoli, R, Trojani A, Pungolino E, Dal Molin A, Bossi LE, Rossi G, D'Adda M, Perego A, Elena C, Turrini M, Borin L, Bucelli C, Malato S, Carraro MC, Spina F, Latargia ML, Artale S, Spedini P, Anghilieri M, Di Camillo B, Baruzzo G, De Canal G, Iurlo A, Morra E, Cairoli R, Trojani, A, Pungolino, E, Dal Molin, A, Bossi, L, Rossi, G, D'Adda, M, Perego, A, Elena, C, Turrini, M, Borin, L, Bucelli, C, Malato, S, Carraro, M, Spina, F, Latargia, M, Artale, S, Spedini, P, Anghilieri, M, Di Camillo, B, Baruzzo, G, De Canal, G, Iurlo, A, Morra, E, Cairoli, R, Trojani A, Pungolino E, Dal Molin A, Bossi LE, Rossi G, D'Adda M, Perego A, Elena C, Turrini M, Borin L, Bucelli C, Malato S, Carraro MC, Spina F, Latargia ML, Artale S, Spedini P, Anghilieri M, Di Camillo B, Baruzzo G, De Canal G, Iurlo A, Morra E, and Cairoli R

Published
2019

66. Progressive Down Regulation of JAK-STAT, Cell Cycle, and ABC Transporter Genes in CD34+/Lin- Cells of Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients at Diagnosis Vs. 12 Months of Nilotinib Treatment Vs. Healthy Subjects

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Bossi, L, Baruzzo, G, Di Camillo, B, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Carraro, M, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Trojani A., Pungolino E., Rossi G., D'Adda M., Bossi L.E., Baruzzo G., Di Camillo B., Perego A., Turrini M., Elena C., Borin L.M., Iurlo A., Malato S., Spina F., Latargia M.L., Spedini P., Artale S., Anghilieri M., Carraro M.C., Bucelli C., De Canal G., Morra E., Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Bossi, L, Baruzzo, G, Di Camillo, B, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Carraro, M, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Trojani A., Pungolino E., Rossi G., D'Adda M., Bossi L.E., Baruzzo G., Di Camillo B., Perego A., Turrini M., Elena C., Borin L.M., Iurlo A., Malato S., Spina F., Latargia M.L., Spedini P., Artale S., Anghilieri M., Carraro M.C., Bucelli C., De Canal G., Morra E., and Cairoli R

Published
2019

67. Different approaches for the solar photocatalytic removal of micro-contaminants from aqueous environment: Titania vs. hybrid magnetic iron oxides

Author

Polliotto, V, Pomilla, F, Maurino, V, Marcì, G, Bianco Prevot, A, Nistico', R, Magnacca, G, Paganini, M, Ponce Robles, L, Perez, L, Malato, S, Polliotto, V., Pomilla, F. R., Maurino, V., Marcì, G., Bianco Prevot, A., Nistico', R., Magnacca, G., Paganini, M. C., Ponce Robles, L., Perez, L., Malato, S., Polliotto, V, Pomilla, F, Maurino, V, Marcì, G, Bianco Prevot, A, Nistico', R, Magnacca, G, Paganini, M, Ponce Robles, L, Perez, L, Malato, S, Polliotto, V., Pomilla, F. R., Maurino, V., Marcì, G., Bianco Prevot, A., Nistico', R., Magnacca, G., Paganini, M. C., Ponce Robles, L., Perez, L., and Malato, S.

Abstract

This work reports on the light-induced heterogeneous photodegradation of four micro-contaminants (MCs): Carbamazepine (C), Flumequine (F), Ibuprofen (I), and Sulfamethoxazole (S), using two different heterogeneous advanced oxidation processes. The first one is the semiconductor photocatalysis, run in the presence of the suspension of a home prepared TiO 2 (TiO 2 HP); the second one is an heterogeneous photo-Fenton process run in the presence of a hybrid magnetic nanomaterial (MB3) with an iron oxides core and an organic shell made of bio-based substances (BBS) isolated from urban biowaste. The two materials work upon two different mechanisms and were already tested (and the action mechanism hypothesized) at the lab scale under model conditions: TiO 2 acts as photocatalyst through the photo-generation of hole/electron pairs able to give rise to oxidation and reduction reactions, whereas hybrid magnetic nanomaterial acts in the presence of H 2 O 2 by a photo-Fenton like mechanism. The results evidenced the better performances of TiO 2 HP (also better than the well-known reference TiO 2 P25). Preliminary photodegradation experiments carried out in a pilot plant under natural solar radiation confirmed the good results obtained with TiO 2 HP. Moreover, in the adopted experimental conditions, the Fe(II) leached from MB3 can be considered as responsible of the MCs degradation through a homogeneous photo-Fenton reaction, where MB3 act as iron reservoir.

Published
2019

68. Deferasirox in the management of iron-overload in patients with myelofibrosis: a multicentre study from the Rete Ematologica Lombarda (IRON-M study)

Author

Elli, E, Iurlo, A, Aroldi, A, Caramella, M, Malato, S, Casartelli, E, Maffioli, M, Gardellini, A, Carraro, M, D'Adda, M, Polverelli, N, Rossi, M, Orofino, N, Carrer, A, Gambacorti-Passerini, C, Antolini, L, Passamonti, F, Elli E. M., Iurlo A., Aroldi A., Caramella M., Malato S., Casartelli E., Maffioli M., Gardellini A., Carraro M. C., D'Adda M., Polverelli N., Rossi M., Orofino N., Carrer A., Gambacorti-Passerini C., Antolini L., Passamonti F., Elli, E, Iurlo, A, Aroldi, A, Caramella, M, Malato, S, Casartelli, E, Maffioli, M, Gardellini, A, Carraro, M, D'Adda, M, Polverelli, N, Rossi, M, Orofino, N, Carrer, A, Gambacorti-Passerini, C, Antolini, L, Passamonti, F, Elli E. M., Iurlo A., Aroldi A., Caramella M., Malato S., Casartelli E., Maffioli M., Gardellini A., Carraro M. C., D'Adda M., Polverelli N., Rossi M., Orofino N., Carrer A., Gambacorti-Passerini C., Antolini L., and Passamonti F.

Published
2019

74. Simultaneous disinfection and microcontaminants elimination of urban wastewater secondary effluent by solar advanced oxidation sequential treatment at pilot scale

Author

Maniakova, G., Polo-Lopez, M. I., Oller, I., Abeledo-Lameiro, M. J., Malato, S., and Rizzo, L.

Subjects
Environmental Engineering, Health, Toxicology and Mutagenesis, Advanced oxidation processes, Hydrogen Peroxide, Wastewater, Wastewater reuse, Pollution, Contaminants of emerging concern, Disinfection, Escherichia coli, Sunlight, Environmental Chemistry, Salmonella spp, Oxidation-Reduction, Waste Management and Disposal, Water Pollutants, Chemical
Abstract

The effect of different times of Fe:Ethylenediamine-N, N'-disuccinic acid (EDDS) dosing and H

Published
2022

84. IDENTIFICAZIONE DI MIRNA E GENI TARGET NELL’ANALISI TRASCRITTOMICA DELLE CELLULE CD34+/LIN- DI PAZIENTI CON LEUCEMIA MIELOIDE CRONICA IN FASE CRONICA DOPO 12 MESI DI TERAPIA CON NILOTINIB

Author

Trojani A, Pungolino E, Dal Molin A, Bossi LE, Rossi G, D'Adda M, Perego A, Elena C, Turrini M, Borin L, Bucelli C, Malato S, Carraro MC, Spina F, Latargia ML, Artale S, Spedini P, Anghilieri M, Di Camillo B, Baruzzo G, De Canal G, Iurlo A, Morra E, Cairoli R, Trojani, A, Pungolino, E, Dal Molin, A, Bossi, L, Rossi, G, D'Adda, M, Perego, A, Elena, C, Turrini, M, Borin, L, Bucelli, C, Malato, S, Carraro, M, Spina, F, Latargia, M, Artale, S, Spedini, P, Anghilieri, M, Di Camillo, B, Baruzzo, G, De Canal, G, Iurlo, A, Morra, E, and Cairoli, R

Subjects
Hematology
Published
2019

85. Wide-transcriptome analysis and cellularity of bone marrow CD34+/lin- cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs. 12 months of first-line nilotinib treatment

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, De Canal, G, Morra, E, Cairoli, R, Trojani A, Pungolino E, Rossi G, D'Adda M, Lodola M, Di Camillo B, Perego A, Turrini M, Orlandi E, Borin L, Iurlo A, Malato S, Spina F, Latargia ML, Lanza F, Artale S, Anghilieri M, Carraro MC, De Canal G, Morra E, Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, De Canal, G, Morra, E, Cairoli, R, Trojani A, Pungolino E, Rossi G, D'Adda M, Lodola M, Di Camillo B, Perego A, Turrini M, Orlandi E, Borin L, Iurlo A, Malato S, Spina F, Latargia ML, Lanza F, Artale S, Anghilieri M, Carraro MC, De Canal G, Morra E, and Cairoli R

Abstract

BACKGROUND: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. The biomolecular mechanisms of CML response to tyrosine-kinase inhibitors are not fully defined. OBJECTIVE: We undertook a gene expression profiling (GEP) study of selected bone marrow (BM) CD34+/lin-cells of chronic-phase CML patients at diagnosis and after 12 months of TKI nilotinib to investigate molecular signatures characterizing both conditions. METHODS:We selected and counted BM CD34+/lin- cells of 30 CML patients at diagnosis and during 3, 6 and 12 months of first-line nilotinib treatment. GEP was performed between CD34+/lin- cells of patients at diagnosis and the same patients after 12 months of nilotinib. RESULTS: The number of BM CD34+/lin- cells dramatically decreased after 3, 6 and 12 months of nilotinib. GEP detected 264 statistically significant differentially expressed genes at diagnosis vs. 12 months of nilotinib. Functional enrichment analysis revealed groups of genes belonging to 14 pathways differentially active during nilotinib treatment. CONCLUSIONS: In conclusion, lipid, glucose and sphingolipid metabolism, insulin resistance, complement and coagulation, platelet activation, cytoscheleton, cell adhesion, transport, B cell differentiation, RAS-signaling pathway, proliferation, growth factors, and apoptosis were significantly deregulated between CML patients at diagnosis and after 12 months of nilotinib.

Published
2018

86. Combining Imatinib-Following-Nilotinib Treatment in First Line Therapy for Chronic Phase Chronic Myeloid Leukemia. Update from the PhilosoPhi34 Study at 24 Months of Follow-up

Author

Pioltelli, M, Pungolino, E, D'Adda, M, Elena, C, Borin, L, Perego, A, Malato, S, Spina, F, Artale, S, Carraro, M, Orofino, N, Anghilieri, M, Farina, M, Latargia, M, Iurlo, A, Trojani, A, Turrini, M, Caramella, M, Spedini, P, Rossi, G, Morra, E, Cairoli, R, Pioltelli ML, Pungolino E, D'adda M, Elena C, Borin LM, Perego A, Malato S, Spina F, Artale S, Carraro M, Orofino N, Anghilieri M, Farina M, Latargia ML, Iurlo A, Trojani A, Turrini M, Caramella M, Spedini P, Rossi G, Morra E, Cairoli R, Pioltelli, M, Pungolino, E, D'Adda, M, Elena, C, Borin, L, Perego, A, Malato, S, Spina, F, Artale, S, Carraro, M, Orofino, N, Anghilieri, M, Farina, M, Latargia, M, Iurlo, A, Trojani, A, Turrini, M, Caramella, M, Spedini, P, Rossi, G, Morra, E, Cairoli, R, Pioltelli ML, Pungolino E, D'adda M, Elena C, Borin LM, Perego A, Malato S, Spina F, Artale S, Carraro M, Orofino N, Anghilieri M, Farina M, Latargia ML, Iurlo A, Trojani A, Turrini M, Caramella M, Spedini P, Rossi G, Morra E, and Cairoli R

Published
2018

87. Identification of genes differently expressed between bone marrow CD34+/LIN-cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs 12 months of first-line nilotinib treatment

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Bucelli, C, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, De Canal, G, Morra, E, Cairoli, R, Trojani A., Pungolino E., Rossi G., D'Adda M., Lodola M., Di Camillo B., Perego A., Turrini M., Orlandi E., Borin L., Iurlo A., Bucelli C., Malato S., Spina F., Latargia M.L., Lanza F., Artale S., Anghilieri M., Carraro M.C., De Canal G., Morra E., Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Bucelli, C, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, De Canal, G, Morra, E, Cairoli, R, Trojani A., Pungolino E., Rossi G., D'Adda M., Lodola M., Di Camillo B., Perego A., Turrini M., Orlandi E., Borin L., Iurlo A., Bucelli C., Malato S., Spina F., Latargia M.L., Lanza F., Artale S., Anghilieri M., Carraro M.C., De Canal G., Morra E., and Cairoli R

Published
2018

88. Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Dal Molin, A, Baruzzo, G, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Cristina, C, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Trojani A, Pungolino E, Rossi G, D'adda M, Lodola M, Dal Molin A, Baruzzo G, Perego A, Turrini M, Elena C, Borin LM, Iurlo A, Malato S, Spina F, Latargia ML, Spedini P, Artale S, Anghilieri M, Cristina CM, Bucelli C, De Canal G, Morra E, Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Dal Molin, A, Baruzzo, G, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Cristina, C, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Trojani A, Pungolino E, Rossi G, D'adda M, Lodola M, Dal Molin A, Baruzzo G, Perego A, Turrini M, Elena C, Borin LM, Iurlo A, Malato S, Spina F, Latargia ML, Spedini P, Artale S, Anghilieri M, Cristina CM, Bucelli C, De Canal G, Morra E, and Cairoli R

Published
2018

89. Jak-2 and Nfkbia Gene Expression Play a Strategic Role in Chronic Myeloid Leukemia (CML) Molecular Response during Early Nilotinib Treatment: The PhilosoPhi34 Data

Author

Pungolino, E, D'Adda, M, Trojani, A, Perego, D, Pioltelli, M, Rossi, G, Perego, A, Elena, C, Iurlo, A, Malato, S, Turrini, M, De Canal, G, Borin, L, Lodola, M, Caramella, M, Artale, S, Spina, F, Latargia, M, Anghilieri, M, Spedini, P, Carraro, M, Di Camillo, B, Gramegna, D, Morra, E, Cairoli, R, Pungolino E, D'adda M, Trojani A, Perego D, Pioltelli ML, Rossi G, Perego A, Elena C, Iurlo A, Malato S, Turrini M, De Canal G, Borin L, Lodola M, Caramella M, Artale S, Spina F, Latargia ML, Anghilieri M, Spedini P, Carraro M, Di Camillo B, Gramegna D, Morra E, Cairoli R, Pungolino, E, D'Adda, M, Trojani, A, Perego, D, Pioltelli, M, Rossi, G, Perego, A, Elena, C, Iurlo, A, Malato, S, Turrini, M, De Canal, G, Borin, L, Lodola, M, Caramella, M, Artale, S, Spina, F, Latargia, M, Anghilieri, M, Spedini, P, Carraro, M, Di Camillo, B, Gramegna, D, Morra, E, Cairoli, R, Pungolino E, D'adda M, Trojani A, Perego D, Pioltelli ML, Rossi G, Perego A, Elena C, Iurlo A, Malato S, Turrini M, De Canal G, Borin L, Lodola M, Caramella M, Artale S, Spina F, Latargia ML, Anghilieri M, Spedini P, Carraro M, Di Camillo B, Gramegna D, Morra E, and Cairoli R

Published
2018

91. Dynamic models for hydrogen peroxide control in solar photo-Fenton systems

Author

Alvarez, J.D., Gernjak, W., Malato, S., Berenguel, M., Fuerhacker, M., and Yebra, L.J.

Subjects
Hydrogen peroxide -- Control, Hydrogen peroxide -- Chemical properties, Solar power plants -- Quality management, Solar power plants -- Buildings and facilities, Solar collectors -- Design and construction, Chemical reaction, Rate of -- Evaluation, Engineering and manufacturing industries, Environmental issues
Abstract

Simulations and real decomposition experiments with hydrogen peroxide induced by dissolved iron and solar illumination were performed in a solar pilot plant with compound parabolic collectors designed for photo-Fenton wastewater treatment. The structure of a gray-box linear model aimed at reproducing system dynamics with parameters dependent on operating conditions when operating around prescribed set-points is proposed. This simple model relates the changes in hydrogen peroxide concentration due to changes in hydrogen peroxide injection, dissolved iron, and solar illumination. Based on this model, control of the hydrogen peroxide concentration at set points between 200-900 mg/L [+ or -] 10 mg/L under dynamic conditions (simultaneous decomposition and addition of hydrogen peroxide by a dosage pump), was achieved. Different basic approaches for controller actuation upon the frequency of the dosage pump were tested, ranging from a simple PI controller to a PI controller plus antiwindup action and feedforward control. From these basic approaches, conclusions can be drawn about the process's behavior under closed-loop control. [DOI: 10.1115/1.2391014]

Published
2007

100. A novel Ti[O.sub.2]-assisted solar photocatalytic batch-process disinfection reactor for the treatment of biological and chemical contaminants in domestic drinking water in developing countries

Author

Duffy, E.F., Touati, F. Al, Kehoe, S.C., McLoughlin, O.A., Gill, L.W., Gernjak, W., Oller, I., Maldonado, M.I., Malato, S., Cassidy, J., Reed, R.H., and McGuigan, K.G.

Subjects
Solar energy -- Research, Infection control, Drinking water, Developing countries, Earth sciences, Petroleum, energy and mining industries
Abstract

The technical feasibility and performance of photocatalytic Ti[O.sub.2] coatings in batch-process solar disinfection (SODIS) reactors to improve potability of drinking water in developing countries have been studied. Borosilicate glass and PET plastic SODIS reactors fitted with flexible plastic inserts coated with Ti[O.sub.2] powder were shown to be 20% and 25% more effective, respectively, than standard SODIS reactors for the inactivation of E. coli K12. Isopropanol at 100 ppm concentration levels was observed to be completely photodegraded after 24 h continuous exposure to 100 mW/[cm.sup.2] simulated sunlight in a similar solar photocatalytic disinfector (SPC-DIS) reactor. The technique for producing the Ti[O.sub.2]-coated plastic inserts is described and demonstrated to be an appropriate and affordable technology for developing countries. Keywords: Photocatalysis; Decontamination; Biological; Chemical; Drinking water

Published
2004

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