Search

Your search keyword '"Mahler, Donald A."' showing total 805 results
Start Over Author "Mahler, Donald A."

Refine your results

more »

more »

more »

more »
805 results on '"Mahler, Donald A."'

53. TRONARTO: A Randomized, Placebo-Controlled Study of Tiotropium/Olodaterol Delivered via Soft Mist Inhaler in COPD Patients Stratified by Peak Inspiratory Flow

Author

Mahler,Donald A, Ludwig-Sengpiel,Andrea, Ferguson,Gary T, de la Hoz,Alberto, Ritz,John, Shaikh,Asif, Watz,Henrik, Mahler,Donald A, Ludwig-Sengpiel,Andrea, Ferguson,Gary T, de la Hoz,Alberto, Ritz,John, Shaikh,Asif, and Watz,Henrik

Abstract

Donald A Mahler,1,2 Andrea Ludwig-Sengpiel,3 Gary T Ferguson,4 Alberto de la Hoz,5 John Ritz,6 Asif Shaikh,7 Henrik Watz8 1Geisel School of Medicine at Dartmouth, Hanover, NH, USA; 2Section of Pulmonary Medicine, Valley Regional Hospital, Claremont, NH, USA; 3KLB Gesundheitsforschung Lübeck GmbH, Lübeck, Germany; 4Department of Medicine, Pulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, USA; 5Cardio-Metabolism and Respiratory, Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany; 6Biostatistics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA; 7Clinical Development & Medical Affairs, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA; 8Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, GermanyCorrespondence: Donald A MahlerMedicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USATel +1 603 542-6777Fax +1 603 543-5613Email mahlerdonald@gmail.comBackground: Inhaled bronchodilator therapy is currently the mainstay of treatment for patients with chronic obstructive pulmonary disease (COPD). Some inhalers require patients to achieve certain inhalation efforts either to activate the device or to deliver medication to the site of action. For dry powder inhalers, low peak inspiratory flow (PIF) can result in poor medication delivery but the clinical significance of this is not well understood.Methods: TRONARTO was a 4-week, randomized, double-blind, placebo-controlled, multicenter, parallel-group study which stratified patients with moderate-to-severe COPD according to their PIF against medium-low resistance at screening. Patients were randomized to receive tiotropium/olodaterol (5 μg/5 μg) or matched placebo delivered via the Respimat® Soft Mist™ inhaler (SMI). After 4 weeks of treatment, we assessed change from baseline in forced expiratory volume in 1 second (FEV1) area under the curve

Published
2021

58. High-Flow Nasal Cannula Therapy for Exertional Dyspnea in Patients with Cancer: A Pilot Randomized Clinical Trial

Author

Hui, David, primary, Mahler, Donald A., additional, Larsson, Liliana, additional, Wu, Jimin, additional, Thomas, Saji, additional, Harrison, Carol A., additional, Hess, Kenneth, additional, Lopez-Mattei, Juan, additional, Thompson, Kara, additional, Gomez, Daniel, additional, Jeter, Melenda, additional, Lin, Steven, additional, Basen-Engquist, Karen, additional, and Bruera, Eduardo, additional

Published
2020
Full Text
View/download PDF

59. Dyspnea

Author

Gifford, Alex H., primary and Mahler, Donald A., additional

Published
2012
Full Text
View/download PDF

60. Mitwirkende Autoren

Author

Abman, Steven H., primary, Badesch, David B., additional, Barnes, Peter J., additional, Bates, Jason H.T., additional, Brown, Kevin K., additional, Brusasco, Vito, additional, Collop, Nancy A., additional, Corrin, Bryan, additional, Davis, Gerald S., additional, DeCamp, Malcolm M., additional, Dweik, Raed A., additional, Feller-Kopman, David, additional, Gifford, Alex H., additional, Green, Curtis, additional, Greenough, Anne, additional, Irvin, Charles G., additional, Irwin, Richard S., additional, Iseman, Michael, additional, Jett, James R., additional, Judson, Marc A., additional, Kaminsky, David A., additional, King, Greg, additional, King, Talmadge E., additional, Klein, Jeffrey, additional, Leslie, Kevin O., additional, Mahler, Donald A., additional, Make, Barry, additional, Marcy, Theodore W., additional, Martin, James G., additional, McCollister, Deborah H., additional, McCormack, Meredith C., additional, Moore, Ernest, additional, Niederman, Michael S., additional, O‘Byrne, Paul M., additional, Parsons, Polly E., additional, Pollina, Elena, additional, Queen, Catheryne J., additional, Rosenfeld, Margaret, additional, Sahn, Steven, additional, Sethi, Sanjay, additional, Silverman, Damon A., additional, and Wise, Robert A., additional

Published
2012
Full Text
View/download PDF

61. Contributors

Author

Ahmed, Asia A., primary, Albert, Richard K., additional, Allen, Mark S., additional, Arenberg, Douglas, additional, Bearfield, Phil, additional, Benfield, Thomas, additional, Berim, Ilya, additional, Bird, Kathryn G., additional, Birring, Surinder S., additional, Brander, Lukas, additional, Brown, Jeremy S., additional, Brown, Kevin K., additional, Bull, Todd M., additional, Burgos, Felip, additional, Calverley, Peter M.A., additional, Camus, Philippe, additional, Carbonara, Paolo, additional, Carlos, William Graham, additional, Cassivi, Stephen D., additional, Cavallazzi, Rodrigo, additional, Celli, Bartolome R., additional, Chang, William Y.C., additional, Chow, Chung-Wai, additional, Churg, Andrew M., additional, Cordier, Jean-François, additional, Cosio, Borja G., additional, Cottin, Vincent, additional, Culver, Bruce H., additional, Daley, Charles L., additional, Davies, Helen E., additional, Denlinger, Chadrick E., additional, Deroose, Christophe, additional, Deschamps, Claude, additional, Dooms, Christophe, additional, Downey, Gregory P., additional, Ferrer, Miquel, additional, Folz, Rodney J., additional, Garrity, Edward R., additional, Gifford, Alex H., additional, Glenny, Robb W., additional, Gray, Kelsey, additional, Green, Ruth H., additional, Gruber, Michael P., additional, Grutters, J.C., additional, Haas, Andrew R., additional, Hage, Chadi A., additional, Haldar, Pranabashis, additional, Hansell, David M., additional, Hart, Nicholas, additional, Herth, Felix J.F., additional, Highland, Kristin B., additional, Holmes, Andre, additional, Hurst, John R., additional, Iannuzzi, Michael C., additional, Barbé, Ferrán, additional, Jardin, Cyrielle, additional, Johnson, Simon R., additional, Kacmarek, Robert M., additional, Kariyawasam, Harsha H., additional, Kaufman, Joel D., additional, Kreit, John W., additional, Krowka, Michael J., additional, Lambert, Mark, additional, Lammers, J.-W.J., additional, Lapinsky, Stephen E., additional, Lee, Y.C. Gary, additional, Bassi, Gianluigi Li, additional, Lipman, Marc C.I., additional, Lomas, David A., additional, MacNee, William, additional, Mahler, Donald A., additional, Malo, Jean-Luc, additional, Marciniak, Stefan J., additional, Marin, José M., additional, Martínez-García, Miguel Ángel, additional, Mazzone, Peter, additional, McGlennan, Alan, additional, McShane, Pamela J., additional, Meniawy, Tarek, additional, Midthun, David E., additional, Miller, Robert F., additional, Moraes, Theo J., additional, Morris, Alison, additional, Mwenge, Gimbada B., additional, Nava, Stefano, additional, Newman, Lee S., additional, Okcay, Aynur, additional, Padley, Simon P.G., additional, Parameswaran, Ganapathi Iyer, additional, Pastis, Nicholas J., additional, Paul, Manju, additional, Pavord, Ian D., additional, Petersen, Hilary, additional, Polkey, Michael I., additional, Quint, Jennifer, additional, Rabe, Klaus F., additional, Ramsay, Michelle, additional, Ratjen, Felix, additional, Rezaei, M. Katayoon, additional, Rinne, Seppo T., additional, Robinson, Bruce W.S., additional, Roca, Josep, additional, Rodenstein, Daniel, additional, Rosado, Jaime Rodríguez, additional, Rosado-de-Christenson, Melissa L., additional, Rose, Cecile, additional, Rossi, Federico Fiorentino, additional, Ruiz, Luis G., additional, Scadding, Glenis K., additional, Schneider, Frank, additional, Schwartz, Arnold M., additional, Sergew, Amen, additional, Sethi, Sanjay, additional, Shaw, Penny J., additional, Simonds, Anita K., additional, Slutsky, Arthur S., additional, Specks, Ulrich, additional, Spiro, Jonathan R., additional, Spiro, Michael, additional, Spiro, Stephen G., additional, Steeds, Richard P., additional, Sterman, Daniel H., additional, Stinson, Kaylan E., additional, Stockley, Robert, additional, Strollo, Diane C., additional, Sulemanji, Demet S., additional, Tanoue, Lynn, additional, Taylor, Magali N., additional, Torres, Antoni, additional, Tullis, Elizabeth, additional, Vachani, Anil, additional, Vandenplas, Olivier, additional, Vansteenkiste, Johan, additional, Vassilakopoulos, Theodoros, additional, Veraldi, Kristen L., additional, Villar, Jesús, additional, Wagner, Peter D., additional, Wallaert, Benoit, additional, Walter, Nicholas, additional, Wedzicha, Jadwiga A., additional, Wells, Athol, additional, Whitters, Deborah, additional, Woodhead, Mark A., additional, Wright, Joanne L., additional, and Wrightson, John M., additional

Published
2012
Full Text
View/download PDF

63. CONTRIBUTORS

Author

Abman, Steven H., primary, Badesch, David B., additional, Barnes, Peter J., additional, Bates, Jason H.T., additional, Brown, Kevin K., additional, Brusasco, Vito, additional, Collop, Nancy A., additional, Corrin, Bryan, additional, Davis, Gerald S., additional, DeCamp, Malcolm M., additional, Dweik, Raed A., additional, Feller-Kopman, David, additional, Gifford, Alex H., additional, Green, Curtis, additional, Greenough, Anne, additional, Irvin, Charles G., additional, Irwin, Richard S., additional, Iseman, Michael, additional, Jett, James R., additional, Judson, Marc A., additional, Kaminsky, David A., additional, King, Greg, additional, King, Talmadge E., additional, Klein, Jeffrey, additional, Leslie, Kevin O., additional, Mahler, Donald A., additional, Make, Barry, additional, Marcy, Theodore W., additional, Martin, James G., additional, McCollister, Deborah H., additional, McCormack, Meredith C., additional, Moore, Ernest, additional, Niederman, Michael S., additional, O'Byrne, Paul M., additional, Parsons, Polly E., additional, Pollina, Elena, additional, Queen, Catheryne J., additional, Rosenfeld, Margaret, additional, Sahn, Steven, additional, Sethi, Sanjay, additional, Silverman, Damon A., additional, and Wise, Robert A., additional

Published
2011
Full Text
View/download PDF

69. Peak Inspiratory Flows

Author

Barnes, Chris N., primary, Mahler, Donald A., additional, Ohar, Jill A., additional, Lombardi, David A., additional, and Crater, Glenn D., additional

Published
2020
Full Text
View/download PDF

82. The Safety and Efficacy of Infliximab in Moderate to Severe Chronic Obstructive Pulmonary Disease

Author

Rennard, Stephen I., Fogarty, Charles, Kelsen, Steven, Long, William, Ramsdell, Joe, Allison, James, Mahler, Donald, Saadeh, Constantine, Siler, Thomas, Snell, Phillip, Korenblat, Phillip, Smith, William, Kaye, Mitchell, Mandel, Michael, Andrews, Charles, Prabhu, Rachakonda, Donohue, James F., Watt, Rosemary, Lo, Kim Hung, Schlenker-Herceg, Rozsa, Barnathan, Elliot S., and Murray, John

Published
2007
Full Text
View/download PDF

89. Pulmonary rehabilitation

Author

Ries, Andrew L., Bauldoff, Gerene S., Carlin, Brian W., Casaburi, Richard, Emery, Charles F., Mahler, Donald A., Make, Barry, Rochester, Carolyn L., Wallack, Richard Zu, and Herrerias, Carla

Subjects
Lung diseases, Obstructive -- Care and treatment, Shortness of breath -- Care and treatment, Practice guidelines (Medicine) -- Evaluation, Breathing exercises -- Standards, Health
Published
2007

94. Revefenacin: A Once-Daily, Long-Acting Bronchodilator For Nebulized Treatment Of COPD

Author

Donohue,James F, Mahler,Donald A, Sethi,Sanjay, Donohue,James F, Mahler,Donald A, and Sethi,Sanjay

Abstract

James F Donohue,1 Donald A Mahler,2,3 Sanjay Sethi4 1Pulmonary Medicine, UNC School of Medicine, Chapel Hill, NC, USA; 2Geisel School of Medicine at Dartmouth, Hanover, NH, USA; 3Director of Respiratory Services, Valley Regional Hospital, Claremont, NH, USA; 4University at Buffalo, State University of New York, Buffalo, NY, USACorrespondence: James F DonohueUNC School of Medicine, 4125 Bioinformatics Building CB#7020, Chapel Hill, NC 27599-0001, USATel +1 984-974-5703Fax +1 984-974-5737Email James_Donohue@med.unc.eduAbstract: Bronchodilation with muscarinic antagonists, β2-agonists, and inhaled corticosteroids remains the foundation of pharmaceutical treatment for patients with stable COPD. These drugs are delivered from a variety of devices, including dry powder inhalers, pressurized metered-dose inhalers, soft-mist inhalers, or nebulizers. Nebulized delivery is often preferable in patients who are elderly, are cognitively impaired, are unable to generate sufficient inspiratory force to use their inhaler, have difficulty coordinating hand-breath activity, are too dyspneic to hold their breath for a sufficient time, and/or may be acutely ill. Revefenacin, a once-daily long-acting muscarinic antagonist for nebulization recently approved by the US FDA for the treatment of patients with COPD, was discovered and developed using “duration and lung selectivity-by-design.” This strategy selected a molecule with a high lung-selective index to maximize bronchodilation and limit systemic anti-muscarinic side effects. In early-phase clinical studies, revefenacin for nebulization led to a rapid onset of bronchodilation that was sustained for 24 hrs in patients with moderate to severe COPD. Revefenacin also demonstrated minimal systemic exposure and good tolerability in these studies. Statistically and clinically significant improvements in lung function (ie, peak and/or trough FEV1) relative to placebo were observed with revefenacin in Phase III cli

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results