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Ao longo do processo de evolução das sociedades capitalistas, tem vindo a intensificar-se a importância conferida à educação/formação no processo de empregabilidade, afirmando-se como variável central do funcionamento dos mercados de trabalho. Este artigo procura perceber, a partir da análise de dados obtidos nos Quadros de Pessoal para o ano de 2007, em que medida é que os níveis de escolaridade continuam a configurar-se como uma variável explicativa de diferentes tipos de relações de emprego dos jovens entre os 15 e os 24 anos. Uma análise de correspondências múltiplas sobre a informação secundária não publicada e a constatação da emergência de padrões novos de inserção profissional, com características distintivas que, todavia, não questionam a associação positiva entre os diplomas escolares e a relação de emprego, constituem os aspectos pertinentes e inovadores deste estudo. Throughout the development of capitalist societies, there has been a steady increase in the importance attributed to education/training in the process of employability: it has asserted itself as a key variable in the functioning of the labour markets. In the light of an analysis of the data in the 2007 Personnel Charts, the aim of this article is to understand to what extent educational levels still represent a variable that explains the different types of employment relationships among young people between 15 and 24 years of age. The relevant and innovative aspects of this study are, firstly, a multiple correspondence analysis of the unpublished secondary information and, secondly, the findings that new patterns of integration into the labour market have emerged, with distinctive characteristics, though they do not call into question the positive association between educational certificates and the employment relationship. Tout au long de l’évolution des sociétés capitalistes, l’importance conférée à ‘éducation/formation dans le processus d’employabilité s’intensifie. Elle s’affirme désormais comme une variable centrale du fonctionnement des marchés du travail. Cet article analyse les données obtenues dans les tableaux des effectifs de l’année 2007 afin de comprendre dans quelle mesure les niveaux de scolarité continuent de constituer une variable pouvant expliquer les différents types de relations d’emploi des jeunes entre 15 et 24 ans. Une analyse des correspondances multiples sur l’information secondaire non publiée et la constatation de l’émergence de nouveaux modèles d’insertion professionnelle qui, malgré leurs caractéristiques distinctives, ne remettent pas en cause l’association positive entre les diplômes scolaires et la relation d’emploi, sont les aspects pertinents et innovants de cette étude. A lo largo del proceso de evolución de las sociedades capitalistas, se ha venido intensificando la importancia conferida a la educación/formación en el proceso de empleabilidad, afirmándose como variable central del funcionamiento de los mercados de trabajo. Este artículo procura entender, a partir del análisis de datos obtenidos en el cuerpo (plazas) profesional para el año de 2007, en qué medida es que los niveles de escolaridad continúan configurándose como una variable explicativa de los diferentes tipos de relaciones de empleo de los jóvenes entre los 15 y los 24 años. Un análisis de correspondencias múltiples sobre la información secundaria no publicada y la constatación de la emergencia de padrones nuevos de inserción profesional, con características distintivas que, todavía, no cuestionan la asociación positiva entre los diplomas escolares y la relación de empleo, constituyen los aspectos pertinentes e innovadores de este estudio.

WOS:000291059900001 (Nº de Acesso Web of Science) “Prémio Científico ISCTE-IUL 2012” A number of studies have concluded that when students have greater confidence about their math skills and are aware of its usefulness, they have a more positive perception of the subject. This article aims to examine whether this pseudo linear trend in the relationship between affective and instrumental dimensions is also true of the university context. Special attention is devoted to the articulation of these dimensions in structuring student perceptions of quantitative methods so as to identify the various forms that this interaction can assume. Our second aim is to understand how the perceptions of these subjects are constructed by students from degree courses in distinct scientific areas. Can we speak of group dynamics whereby socialization within each degree course triggers the sharing of similar perceptions? We concluded that a certain linear trend can also be identified in the university context in the relationship between the affective dimension and usefulness of quantitative methods i.e., that the highest levels in the perception of the usefulness of these subjects corresponded to the highest levels of self confidence and enjoyment of the subjects. However, in addition to this scenario there is another configuration in which negative feelings coexist with the recognition of the usefulness of quantitative methods subjects. Namely, lower levels of self confidence and enjoyment of these subjects can also be associated with high levels of perceived usefulness. We also concluded that there is evidence of what we designated a certain course culture in the perceptions about quantitative methods. Nevertheless, when our observation is extended to the scientific area the heterogeneity of the perceptions becomes evident. Another important finding is the rejection of the thesis, at least in the university context, that defends the lack of self-confidence in quantitative methods among females student.

Hypothenar hammer syndrome (HHS) is a rare condition and is a term used to described an aneurysm or thrombosis of the ulnar artery. It is considered an occupational or recreational injury and usually results of repetitive trauma to the hypothenar region, where th unique anatomy after the artery leaves the Guyon canal, allows the arterial injury. Clinical manifestations are more often unilateral, involving the dominant hand. However, some authors report the existence of a previous arteriopathy, predisposing to the injury, after repetitive palmar trauma.The authors report the clinical case of a 60 year-old woman, with an ulnar aneurysm in the non dominant hand, without evident existence of repetitive trauma. The pathological examination of the artery revealed muscular hyperplasia, without the characteristics of muscular fibrodysplasia. The authors believe that this case, once again, demonstrates the existence of an autonomous and "previous" arteriopathy associated to the traumatic lesion.

É recorrente concluir-se que níveis mais elevados de autoconfiança dos alunos, relativamente às suas capacidades para interagir com a matemática, associados a uma maior utilidade percebida desta concorrem para os alunos terem representações positivas da disciplina. Um dos objectivos deste artigo é averiguar se no contexto universitário se mantém esta tendência linear na relação entre as duas dimensões - afectiva e instrumental - estruturantes das representações das disciplinas de métodos quantitativos. Um segundo objectivo consiste em perceber como é que os alunos de diferentes cursos (de áreas científicas distintas) geram as suas representações relativamente a essas disciplinas. Foi aplicado um inquérito por questionário a uma amostra de alunos numa instituição universitária. Para a definição dos padrões de representações, foi usada a Análise de Correspondências Múltiplas e, para a identificação de factores explicativos dos perfis dos alunos, foi usada a Regressão Categorial. Os resultados evidenciam que o espaço das representações dos métodos quantitativos em contexto universitário é um espaço marcado pela heterogeneidade, mas cuja complexidade ultrapassa essa tendência linear na relação entre a dimensão da utilidade e a dimensão afectiva. Outra das conclusões é a não sustentabilidade da tese que aponta (pelo menos em contexto não universitário) para a feminização da falta de autoestima e da autoconfiança para lidar com disciplinas dessa área científica. Conclui-se, ainda, que parece existir uma certa cultura de curso, na medida em que os cursos tendem a reflectir um padrão predominante de representações dos métodos quantitativos. It is often concluded that higher levels of self-confidence in pupils in relation to their ability to interact with mathematics, associated to the perception of the latter's greater utility contributed for pupils making positive representations of this discipline. One of the objectives of this article is to inspect if in the university context this linear trend is maintained in the relation between the two dimensions – affective and instrumental – which structure the representations of the disciplines of quantitative methods. A second objective consists in observing how students from different courses (from different scientific areas) create their representations about these disciplines. A questionnaire was applied to a sample of students from a university institution. The definition of patterns of representations was done through the use of Multiple Correspondence Analysis (MCA), and Categorical Regression (Catreg) was employed to identify explaining factors in the students' profile. The results show that the space of the representations of quantitative methods in a university context is marked by heterogeneity, with a complexity that goes beyond this linear trend in the relation between the utility dimension and the affective dimension. Another conclusion is about the untenability of the thesis that points (at least in a non-university context) to the feminization of the lack of self-esteem and self-confidence to deal with disciplines from this scientific area. A further conclusion is that a course culture seems to exist, insofar as the courses tend to reflect a predominant pattern of representations of the quantitative methods.

Nesta investigação é realizada uma análise quantitativa do fenómeno do recasamento em Portugal, com base nas estatísticas demográficas entre 2001 e 2005, que permitiu a identificação de algumas regularidades: os divorciados recasam muito mais frequentemente do que os viúvos; os homens recasam mais frequentemente do que as mulheres; a idade é um factor determinante na probabilidade de recasar, sendo a situação favorável aos mais jovens. A comparação entre as características dos indivíduos envolvidos num recasamento com as dos primeiros casamentos, permite verificar que os primeiros são tendencialmente mais velhos, passaram maioritariamente por uma situação de coabitação anterior, têm mais frequentemente filhos de relações anteriores e menos vulgarmente filhos em comum, tendem a casar menos segundo a celebração católica e têm tendencialmente habilitações mais baixas que os cônjuges de primeiros casamentos. Através da articulação entre a Análise de Correspondências Múltiplas e a Análise de Clusters, construiu-se uma tipologia do recasamento onde se identificaram três grupos com perfis distintos: i) casamentos entre cônjuges anteriormente viúvos, ambos com filhos não comuns, com idades avançadas e baixas habilitações, que se unem em regime de separação de bens; ii) uniões entre mulheres divorciadas com filhos de relações anteriores e homens solteiros mais jovens e sem filhos, onde predomina o regime de comunhão de adquiridos e habilitações de nível intermédio; iii) matrimónios entre homens divorciados com filhos e mulheres solteiras mais jovens, sem filhos de relações anteriores, sendo este o grupo ao qual está mais associado o regime da comunhão geral de bens e habilitações académicas mais elevadas.

Quer seja nos meios de comunicação social, quer seja em conversas ouvidas entre amigos, todos os dias deparamos com referências à matemática, em particular ao insucesso escolar que aí se regista e à “aversão” que um conjunto bastante vasto de pessoas sente por ela. Na tentativa de perceber como se constrói esta valorização negativa da disciplina surge como imperioso o conhecimento das representações sociais da matemática. Um inquérito por questionário, aplicado a uma amostra de alunos do 9.º ano do concelho de Lisboa, permitiu concluir que aquilo que mais sobressai na sua relação com a matemática é o sentimento de insegurança face ao seu elevado nível de dificuldade, que coexiste com o reconhecimento da sua importância e utilidade. Every day, in the media or in conversations among friends, we come across references to mathematics and, in particular, to the failure in school associated with it and the “aversion” that a fairly large number of people feel towards it. For any attempt to understand how this negative assessment of the subject has built up, knowledge of the social representations of mathematics appears indispensable. From a questionnaire survey among a sample of 9th grade pupils in the municipality of Lisbon it was possible to conclude that the salient characteristic of their relationship with mathematics is that a sense of insecurity arising from the difficulty of the subject coexists with a recognition of its importance and usefulness. Que ce soit dans les médias ou dans les conversations entre amis, les mathématiques reviennent souvent à l’ordre du jour, en particulier pour évoquer de l’échec scolaire ou bien l’aversion qu’un nombre de personnes éprouvent pour cette matière. Afin de comprendre comment se construit cette perception négative des mathématiques, il est essentiel d’en connaître les représentations sociales. Une enquête par questionnaire menée à Lisbonne, auprès d’un échantillon d’élèves en 9 ème année de scolarité (15 ans de moyenne d’âge), a permis de conclure que ce qui ressort le plus dans leur relation avec les mathématiques est le sentiment d’insécurité face au degré de difficulté élevé de cette matière, allié à la reconnaissance de son importance et de son utilité. Bien sea en los medios de comunicación social o en las conversaciones entre amigos, todo los días nos encontramos con referencias a las matemáticas, más concretamente al fracaso escolar que aquí se registra y a la “aversión” que un conjunto bastante amplio de personas siente por esta disciplina. En el intento de comprender como se construye esta valoración negativa de la materia surge como imperioso el conocimiento de las representaciones sociales de las matemáticas. Un sondeo realizado por cuestionario, aplicado a un segmento de alumnos de 9.º curso (3.º de ESO) del municipio de Lisboa, permitió concluir que lo más destacable en su relación con las matemáticas es el sentimiento de inseguridad ante su elevado nivel de dificultad, que coexiste con el reconocimiento de su importancia y utilidad.

© 2012 Fernandes et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms., Introduction: Somatostatin analogs (SSAs) are used as part of standard treatment for advanced neuroendocrine tumors (NETs). The mechanisms behind the antiproliferative action of SSAs remain largely unknown, but a connection with the mammalian target of rapamycin (mTOR) signaling pathway has been suggested. Our purpose was to evaluate the activation status of the AKT/mTOR pathway in advanced metastatic NETs and identify biomarkers of response to SSA therapy. Patients and methods: Expression of phosphatase and tensin homolog (PTEN), phosphorylated (p)-AKT(Ser473), and p-S6(Ser240/244) was evaluated using immunohistochemistry in archival paraffin samples from 23 patients. Expression levels were correlated with clinicopathological parameters and progression-free survival under treatment with SSAs. Results: A positive association between p-AKT and p-S6 expression was identified (P = 0.01) and higher expression of both markers was observed in pancreatic NETs. AKT/mTOR activation was observed without the loss of PTEN expression. Tumors showing AKT/mTOR signaling activation progressed faster when treated with SSAs: higher expression of p-AKT or p-S6 predicted a median progression-free survival of 1 month vs 26.5 months for lower expression (P = 0.02). Conclusion: Constitutive activation of the AKT/mTOR pathway was associated with shorter time-to-progression in patients undergoing treatment with SSAs. Larger case series are needed to validate whether p-AKT(Ser473) and p-S6(Ser240/244) can be used as prognostic markers of response to therapy with SSAs.

© Springer Science+Business Media Dordrecht 2014, Colorectal cancer (CRC) is the third most common malignant disease in men and the second in women worldwide. CRC relapse occurs mostly in liver and lungs, decreasing the 5-year survival to 6 %. Metadherin (MTDH) is overexpressed in several types of cancer, has been implicated in proliferation, invasion, metastasis, angiogenesis, and chemoresistance, and is a factor of poor prognosis in CRC. In this work we addressed the prognostic significance of MTDH expression in CRC progression to the lungs. We found that MTDH gene was more frequently amplified (copy number >1.8) in patients with CRC and relapse to the lung, when compared to patients without lung metastases (17.4 vs 100 %; p < 0.001). We observed a correlation between MTDH gene copy number and MTDH expression by IHC (p = 0.0001). Next we also analyzed MTDH expression by IHC in samples from 85 patients diagnosed with CRC, stage II or III, M0, with at least 3 years of follow-up. Kaplan-Meier survival analysis showed that lung relapse-free survival (HR 5.29, 95 % CI 1.90-14.77, p = 0.0004), liver relapse-free survival (HR 8.59, 95 % CI 0.99-74.18, p = 0.003), relapse-free survival (HR 4.85, 95 % CI 1.88-12.45, p = 0.0003) and overall survival (HR 3.75, 95 % CI 1.15-12.18, p = 0.018) were significantly lower in the group with high MTDH expression. Multivariate analysis showed that high MTDH expression was an independent factor for all outcomes. This study demonstrates that high MTDH expression is a biomarker of relapse in CRC, including lung-specific relapse. Determination of MTDH expression in primary CRC may be useful in the earlier detection of lung metastases in patients with high expression and increased risk., This project was supported by a Grant from Fundação para a Ciência e Tecnologia (PIC/IC/82821/2007).S. Casimiro was supported by a Post-Doctoral Grant (SFRH/BPD/34801/2007) and J. Tato-Costa by a PhD Grant (SFRH/BD/45219/2008) from Fundação para a Ciência e Tecnologia.

O objetivo deste artigo é realizar uma análise comparativa sobre a evolução do divórcio em casais nacionais e binacionais residentes em Portugal entre 2001-2010. O artigo inicia com uma revisão crítica dos principais estudos sobre divórcios binacionais, para posteriormente analisar a evolução deste fenómeno ao longo dessa década. Para tal, centrar-nos-emos na estrutura do divórcio tendo em conta os distintos perfis sociais e familiares, a situação educativa e o contexto profissional dos cônjuges. Numa parte final, resumem-se criticamente as principais conclusões alcançadas e apresentam-se linhas de investigação futuras The aim of this article is to develop a comparative analysis on the evolution of divorces in national and bi-national couples living in Portugal between 2001-2010. The article starts by critically revising previous studies on divorce in binational couples, to then analyze its evolution during the decade 2001-2010. As such, we will focus on the structure of divorce having into account different social and family profiles, the level of education and the professional context of the spouses. At a final stage, we will critically summarize the results found here and suggest future lines of research L’objetif de cet article est analyser comparativement l’évolution du divorces entre les couples nationaux et bi-nationaux résidents au Portugal entre 2001-2010. L’article commence par une révision critique des principalles études sur les divorces bi-nationaux, pour analyser postérieurement l’évolution de ce phénomène au long de la décade. Aussi, concentrons-nous à une structure du divorce, ayant en compte les différents profilés sociales et familiales, la situation éducative et le contexte professionnel des couples. Dans la dernière partie, on résume les principales conclusions et principales lignes d’investigation futures El objetivo de este artículo es analizar comparativamente la evolución del divorcio en parejas nacionales y binacionales residentes en Portugal entre 2001-2010. El artículo se inicia con una revisión crítica de los estudios sobre divorcios binacionales, para posteriormente analizar la evolución del fenómeno a lo largo del periodo referido. Para ello, nos centraremos en la estructura del divorcio según los distintos perfiles sociales y familiares, el nivel educativo y el contexto profesional de los cónyuges. En el apartado final, se resumen las principales conclusiones y se presentan líneas futuras de investigación

This article focuses on the Portuguese case to discuss the employment insertion of graduates. It starts by presenting a typology of professional situations with the purpose of analyzing graduate transition from higher education to the labor market. The heuristic potential of the typology is then described, showing its key role when analyzing two important topics in the study of the professional situation of graduates: i) the unequal distribution of individuals in the occupation structure and ii) the relationship between the graduates' positions in the occupational structure and the work orientations. Two important conclusions are drawn: in Portugal higher education continues to be permeated by reproduction logics of inequalities that go beyond this; the importance of intrinsic and extrinsic values bears almost no relation to variations in levels of job security and material prosperity in this population, for whom intrinsic values are of great relevance Apresenta-se neste artigo uma tipologia de inserção profissional dos diplomados do ensino superior português, utilizada na análise i) da distribuição desigual dos indivíduos na estrutura ocupacional e ii) da relação entre as posições dos graduados na estrutura ocupacional e as orientações para o trabalho. Conclui- se que o ensino superior continua a ser permeado por lógicas de reprodução das desigualdades que vão para além dele e que, entre os seus diplomados, são os valores intrínsecos os de maior relevância, sendo que a importância por eles atribuída aos valores associados ao trabalho quase não tem relação com os níveis de segurança no emprego e a sua prosperidade Cet article se concentre sur le cas portugais pour discuter l'insertion de l'emploi des diplômés. Il présente une typologie de insertion professionelle qui a été utilisé pour analiser i) la répartition inégale des individus dans la structure de l'occupation, et ii) la relation entre les positions des diplômés dans la structure professionnelle et les orientations du travail. On conclude que l'enseignement supérieur continue imprégné par des logiques de reproduction des inégalités, et que l'importance des valeurs intrinsèques et extrinsèques porte presque aucun rapport avec des variations dans les niveaux de sécurité de l'emploi et la prospérité matérielle dans cette population, pour qui les valeurs intrinsèques sont les plus importants. Se presenta en este artículo una tipología de inserción profesional de los graduados portugueses, que se utilizó en el análisis i) de la distribución desigual de los individuos en la estructura ocupacional y ii) de la relación entre las posiciones de los graduados en la estructura ocupacional y las directrices para el trabajo. Se concluye que la educación superior sigue siendo penetrado por la lógica de la reproducción de las desigualdades; que, entre los graduados, son los valores intrínsecos los de mayor relevância; y que la importancia dada a los valores asociados con el trabajo no tiene casi ninguna relación con los niveles de seguridad en el empleo y la prosperidad

The increase in the number of divorces in Portugal is the result of more than just the changes in marriage and family structures that began in the 1960s. Although divorce is currently closely associated with structures and social representations of marriage and is considered to be a normal phenomenon, there have been very few studies of divorce in Portugal. info:eu-repo/semantics/acceptedVersion

Submitted by ciencia null (ciencia@iscte.pt) on 2018-06-21T11:50:48Z No. of bitstreams: 1 2018 (A) - Estilos de vida e atividade física. Identificação de perfis das representações e práticas de lazer em adolescentes.pdf: 290182 bytes, checksum: cde4d710f1eed07bd7d8cd0a202f75ff (MD5) Made available in DSpace on 2018-06-21T11:51:22Z (GMT). No. of bitstreams: 2 "deposit.zip": 258295 bytes, checksum: dc524e60003d586ad2e29989f1bd6a9d (MD5) 2018 (A) - Estilos de vida e atividade física. Identificação de perfis das representações e práticas de lazer em adolescentes.pdf: 290182 bytes, checksum: cde4d710f1eed07bd7d8cd0a202f75ff (MD5) Previous issue date: 2018 info:eu-repo/semantics/publishedVersion

Em 1932, para medir noções complexas como crenças, perceções ou opiniões, Likert preconizou a utilização de afirmações, cada uma delas a ser pontuada numa valoração de um a cinco, de acordo com o grau de concordância do respondente. Desde essa altura, várias alternativas de formatação das respostas foram sugeridas, diferindo quer no número de pontos a utilizar, quer nos descritores verbais incluídos e, mais recentemente, propondo a substituição de um conjunto finito de opções de resposta por uma linha contínua. Nesta comunicação pretende-se analisar em que medida o formato de resposta oferecido condiciona os resultados obtidos. Mediram-se as percepções acerca da Matemática, em três dimensões (enquanto domínio masculino, importância de compreensão dos conceitos eutilidade), cada uma delas composta por seis itens. Construíram-se quatro tipos de questionários: em dois deles as afirmações são avaliadas através do posicionamento num segmento de recta, sendo o primeiro etiquetado nos extremos e no ponto central e o segundo apenas nos extremos; no terceiro são usados itens de Likert com 5 pontos, todos etiquetados (discordo completamente, discordo, não concordo nem discordo, concordo e concordo completamente); o último tipo de questionário difere do anterior por ter apenas os extremos etiquetados. Serão apresentados os resultados da comparação das respostas item a item e também das escalas obtidas por soma dos respectivos itens teoricamente definidos. info:eu-repo/semantics/publishedVersion

The purpose of this study is to evaluate the similarity of results obtained with linear and nonlinear PCA over Likert-type items. As part of a wider project about students' perceptions of mathematics, this study analyses two dimensions: the usefulness of mathematics and the importance of understanding the concepts. Each dimension is theoretically structured by six items, three with a positive connotation and three with a negative connotation (adaptations of Fennema and Sherman, 1976 and Kloosterman and Stage, 1992). Each item is a statement that seeks to register the intensity of agreement on a 5-point scale. Four questionnaires were constructed: in the first two (A and B) the statements are evaluated by marking the response on a line segment (Visual Analogue Scale), labelled in the extreme and at the midpoint (A) or only at the extremes (B). In the third (C), Likert-type items with five labelled points are used (completely disagree, disagree, neither agree nor disagree, agree and totally agree), while in D only the extremes are labelled. This work concerns only questionnaires type C and D. Since the variables of this type are structurally ordinal variables (Gob et al, 2007), the use of a nonlinear principal components (e.g. CATPCA) is a possibility for its interdependency analysis. However, the use of linear techniques (PCA) has been widespread as a form of preferential treatment of such data. Do both techniques lead to similar results? If not, then the linearity of the treatment of such items can be questioned. Drawing on the data collected in the study mentioned, and using the balanced bootstrap as proposed in Linting et al (2007), several confidence intervals are built for the objects scores, either obtained through PCA or CATPCA, and for the correlation coefficient between paired dimensions. With these confidence intervals we expect to have a perception of the comparability of the linear and non-linear solutions. info:eu-repo/semantics/publishedVersion

The glutathione S-transferases appear to form part of a protective mechanism against the development of cancer where environmental chemical carcinogens are involved. In humans one member of the mu class gene family (GSTM1) has been shown to be polymorphic and is only expressed in ~50% of individuals. Previous studies have shown a possible link between the null phenotype and susceptibility to cancer but have been equivocal regarding stomach cancer. To evaluate any association in Portuguese gastric cancer individuals with GSTM1 variability, we performed GST M 1 polymorphism by PCR amplification in 148 gastric cancer patients and in 84 healthy control individuals. We found no statistical differences between the gastric cancer and control populations (wild type phenotype: 52%, 48%; null phenotype: 48%, 52%, respectively). A subset analysis into site of tumour also revealed no significant differences between the groups, although we found a slight increase of the wild type phenotype in the samples of the antrum compared with the control population (57% vs 48%, respectively; 2= 1.18; p 0.28) and a slight increase of the null phenotype in the signet ring cells/mucocellular group (2= 1.05; p 0.3). However, in both cases it did not reach statistical significance. A subset analysis of the histological groups following the WHO criteria revealed a statistically significant difference (2= 3.704; p 0.05) between the moderately differentiated gastric adenocarcinoma and the presence of the wild type phenotype. These results do not support the hypothesis that the GSTM1 null phenotype predisposes to gastric cancer in the Portuguese population and the moderately differentiated gastric adenocarcinoma seems to be associated with the presence of the G STM 1 wild type phenotype.

UID/SOC/04647/2013 SFRH/BPD/112462/2015; SFRH/BPD/77611/2011 Although the institutionalization of sociology in Portugal was only made possible after the revolution of 1974, it is currently characterized by a remarkable vitality, apparent for instance in the number and diversity of members of the Associação Portuguesa de Sociologia as well as that of participants at its national conferences. However, significant challenges have also emerged, stemming not only from the expansion and diversification of sociologists, but also from the economic crisis, austerity policies, the enlargement of social science specializations, and the pressures in politics and the media to give advantage to business, law and engineering professionals, courses and research. The present paper will be organized in three sections. Firstly, we will analyse the existing courses of sociology in Portugal (at BA, master and PhD level) as well as the regional location, activity sectors and professional positions of those who have graduated in sociology. Secondly, we will discuss the participation of those different profiles in the Associação Portuguesa de Sociologia throughout time and the ongoing efforts to improve such participation. According to Burawoy’s typology, we suggest that, despite some tensions, academic and critical sociologies have been developed and working together in Portugal, but the connection with a large group of applied sociologists has weakened over time. Public sociology may be the missed link to foster a dialogue among sociologists and other sectors of society. Our national association’s current strategy to develop such links will be sketched. Thirdly, we will present a broad overview of the internationalization of Portuguese sociology, through collaboration in projects and networks, especially with Europe and Portuguese-speaking countries like Brazil and Angola. publishersversion published

It is internationally recommended and also a wish of people with dementia to live at home for as long as possible. Improving or maintaining their functional independence is therefore a priority. Health-related physical fitness (HRPF) and other meaningful domains (e.g., health-related quality of life) are important to maintain or improve the performance on activities of daily living and can influence and be influenced by being physically active. Nevertheless, physical activity programmes for people with dementia, especially conducted at home, are scarce. Thus, the main aim of this research work was to develop/adapt, implement and evaluate the Lifestyle Integrated Functional Exercise for People with Dementia (LiFE4D). Specifically, it aimed to: i) identify and synthetize the effects of home-based physical activity programmes for people with dementia; ii) design/adapt LiFE4D with daily routine strategies to maintain or increase HRPF; iii) examine the feasibility, efficacy and effectiveness of LiFE4D on HRPF and additional meaningful measures; iv) explore the perceived motivators/facilitators, barriers and impacts of LiFE4D in people with dementia and their carers. Five studies (systematic review, protocol and original studies I, II and III), one manual and one book chapter were conducted. The systematic review addressed the specific aim i). This study showed that, despite high heterogeneity of interventions and domains assessed, home-based physical activity programmes seem to be safe and effective in delaying cognitive function decline, and improving behavioural and psychological symptoms of dementia, activities of daily living performance, HRPF and carer’s burden. The protocol study, manual and book chapter addressed aim ii). Original studies I (pilot study) and II (main study) addressed aim iii). Findings have shown that LiFE4D is feasible and safe to be conducted at home of people with dementia, and it is an efficacious and effective intervention to improve HRPF and health-related quality of life in this population. Original study III (qualitative study) addressed aim iv). This study showed that people with dementia and their carers perceived more motivators/facilitators than barriers, and identified only positive impacts from their participation in LiFE4D. Although different perceptions about LiFE4D existed, both people with dementia and their carers identified the subthemes professional support, easy exercises, tiredness and lack of time in common. This research offers relevant information to increase the confidence of health professionals into promoting physical activity at home for people with dementia, with a person-centred, innovative intervention, capable of promoting the independence of this population, so they can live well and longer at home. This thesis adds important knowledge to guide future interventions, guidelines and political decisions to increase access to physical activity at home for people living with dementia. É internacionalmente recomendado e também um desejo das pessoas com demência que estas vivam em casa o máximo de tempo possível. Manter ou melhorar a sua independência funcional é, portanto, uma prioridade. A aptidão física relacionada com a saúde e outros domínios significativos (p.e., qualidade de vida relacionada com a saúde) ajudam a manter ou melhorar o desempenho nas atividades de vida diária (AVD) e podem influenciar e ser influenciados pela atividade física (AF). No entanto, os programas de AF para pessoas com demência, principalmente domiciliários, são escassos. Assim, o objetivo principal deste trabalho foi desenvolver/adaptar, implementar e avaliar o Lifestyle Integrated Functional Exercise em pessoas com demência (LiFE4D). Os objetivos específicos foram: i) identificar e sintetizar os efeitos de programas de AF no domicílio para pessoas com demência; ii) desenvolver/adaptar o LiFE4D com estratégias envolvidas na rotina diária para manter ou aumentar a aptidão física relacionada com a saúde; iii) examinar a viabilidade, eficácia e efetividade do LiFE4D na aptidão física relacionada com a saúde e medidas significativas adicionais; e iv) explorar os motivadores/ facilitadores, barreiras e impactos do LiFE4D percecionados pelas pessoas com demência e seus cuidadores. Para dar resposta a estes objetivos, foram realizados cinco estudos (revisão sistemática, protocolo e estudos originais I, II e III), um manual e um capítulo de um livro. A revisão sistemática abordou o objetivo específico i). Este estudo demonstrou que, apesar da elevada heterogeneidade nas intervenções e domínios avaliados, a AF no domicílio parece ser segura e eficaz no atraso do declínio da função cognitiva, e na melhoria dos sintomas comportamentais e psicológicos de demência, do desempenho nas AVD, da aptidão física relacionada com a saúde e da sobrecarga do cuidador. O protocolo, o manual e o capítulo do livro abordaram o objetivo ii). Os estudos originais I (estudo piloto) e II (estudo principal) abordaram o objetivo iii). Os resultados demonstraram que o LiFE4D é viável e seguro para ser conduzido no domicílio de pessoas com demência, e é eficaz e efetivo na melhoria da aptidão física e qualidade de vida relacionadas com a saúde nesta população. O estudo original III (estudo qualitativo) deu resposta ao objetivo iv). Este estudo demonstrou que as pessoas com demência e seus cuidadores percecionaram mais motivadores/facilitadores do que barreiras e identificaram apenas impactos positivos da sua participação no LiFE4D. Apesar das diferentes perceções sobre o LiFE4D, tanto as pessoas com demência como os seus cuidadores identificaram os subtemas suporte profissional, facilidade dos exercícios, cansaço e falta de tempo em comum. Esta investigação oferece informações relevantes para aumentar a confiança dos profissionais de saúde na promoção de AF no domicílio de pessoas com demência, com uma intervenção centrada na pessoa, inovadora e capaz de promover a independência desta população, para que vivam bem e por mais tempo em casa. Esta tese agrega conhecimentos importantes para orientar intervenções futuras, diretrizes e decisões políticas para aumentar o acesso à AF no domicílio de pessoas que vivem com demência. Programa Doutoral em Gerontologia e Geriatria

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Tese de doutoramento em Química (Química Inorgânica), apresentada à Universidade de Lisboa através da Faculdade de Ciências, 2009 Nível de preservação: critical, Criado em: 2009-04-02 15:16:19, Criado por: creator:MARTA, Alterado em: 2009-08-12 10:38:07, Modificado por: viewer:internal Made available in DSpace on 2010-07-27T08:59:49Z (GMT). No. of bitstreams: 2 17278_Caract_de_Macromoleculas_Biol_Org_Marinhos_Tese_Dout_Quimica_2008(Ma.pdf: 13965879 bytes, checksum: 7d0d68f5c30b9ce306be1b35dd8aa380 (MD5) 17278.xml: 9037 bytes, checksum: a62a40d37795c92e1e7d84f455ecdabf (MD5) Previous issue date: 2009 Fundação para a Ciência e Tecnologia (FCT), (SFRH/BD/9034/2002 financiada pelo POCI 2010 Formação Avançada para a Ciência Medida IV.3 e do projecto POCTI/QUI/45670/2002)