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Testosterone is one possible biomarker for depression risk among men and women. Both high and low levels of testosterone have been associated with depression, at least among men. Testosterone may be associated only with specific symptoms of depression, which might help to explain inconsistencies in previous results.We examined the cross-sectional associations between total testosterone and the specific symptoms of depression using pooled data across three cycles of NHANES (2011–2012, 2013–2014, and 2015–2016). The sample included 4253 men and 5102 women. Testosterone was modelled as 1) a dichotomous (low testosterone cut-off

Personality describes the average behaviour and responses of individuals across situations; but personality traits are often poor predictors of behaviour in specific situations. This is known as the “personality paradox”.We evaluated the interrelations between various trait and state variables in participants’ everyday lives. As state measures, we used 1) experience sampling methodology (ESM/EMA) to measure perceived affect, stress, and presence of social company; and 2) heart rate variability and 3) real-time movement (accelerometer data) to indicate physiological stress and physical movement. These data were linked with self-report measures of personality and personality-like traits.Trait variables predicted affect states and multiple associations were found: traits neuroticism and rumination decreased positive affect state and increased negative affect state. Positive affect state, in turn, was the strongest predictor of observed movement. Positive affect was also associated with heart rate and heart rate variability (HRV). Negative affect, in turn, was not associated with neither movement, HR or HRV.The study provides evidence on the influence of personality-like traits and social context to affect states, and, in turn, their influence to movement and stress variables.

Previous research has provided evidence that females are generally the more selective sex in humans. Moreover, both sexes have been found to be more selective in long-term mating compared to short-term mating. In this study, we have examined the effects of sex, mating strategy (preferred relationship length) and their interaction on mate preferences (i.e., mate selection criteria) in an egalitarian Nordic society, namely Norway. The study sample consisted of 1,000 individuals, 417 of whom were male and 583 female respondents. According to our findings, men were more selective in physical appearance, whereas women were more selective in all the other mate preferences (e.g., understanding, dominant, kind, intellectual etc.). The respondents that were seeking short-term relationships had higher preference for physical appearance, humorousness and sociability. On the other hand, the respondents that were seeking long-term relationships were more selective in most of the other mate preferences (i.e., understanding, kind, cultivated, domestic, reliable, and similar). Interestingly, no interaction effect was found between sex and mating strategy in that differences between long-term and short-term seekers in mate preferences did not change depending on sex. This suggests that men and women value the same traits in short-term relationships.

Purpose: Inflammatory bowel disease (IBD) refers to a spectrum of autoimmune diseases, which result in chronic intestinal inflammation. Previous findings suggest a role for diet, nutrition and dysbiosis of the gut microbiota in both the development and progression of the condition. Vitamin B12 is a key cofactor of methionine synthase and is produced solely by microbes. Previous work links increased levels of homocysteine, a substrate of methionine synthase, MetH, to IBD indicating a potential role for vitamin B12 deficiency in intestinal injury and inflammation. This study assessed the role of vitamin B12 in shaping the gut microbiota and determining responses to intestinal injury using a reproducible murine model of colitis.Methods: The effects of vitamin B12 supplementation and deficiency were assessed in vivo; 3-week-old post-weanling C57Bl/6 mice were divided into three dietary treatment groups: (1) sufficient vitamin B12 (50 mg/Kg), (2) deficient vitamin B12 (0 mg/Kg) and (3) supplemented vitamin B12 (200 mg/Kg) for a period of 4 weeks. Intestinal injury was induced with 2% dextran sodium sulphate (DSS) via drinking water for 5 days. The impact of varying levels of dietary vitamin B12 on gut microbiota composition was assessed using 16S rRNA gene sequencing from fecal samples collected at day 0 and day 28 of the dietary intervention, and 7 days following induction of colitis on day 38, when blood and colonic tissues were also collected.Results: No significant alterations were found in the gut microbiota composition of disease-free animals in response to dietary interventions. By contrast, after DSS-induced colitis, >30 genera were significantly altered in vitamin B12 deficient mice. Altered B12 levels produced no significant effect on composite disease-activity scores; however, administration of a B12 deficient diet resulted in reduced DSS-induced epithelial tissue damage.Conclusions: Vitamin B12 supplementation does not alter the gut microbiota composition under healthy conditions, but does contribute to differential microbial responses and intestinal dysbiosis following the induction of experimental colitis.

The Europlanet-2020 programme, which ended on Aug 31st, 2019, included an activity called VESPA (Virtual European Solar and Planetary Access), which focused on adapting Virtual Observatory (VO) techniques to handle Planetary Science data. This paper describes some aspects of VESPA at the end of this 4-years development phase and at the onset of the newly selected Europlanet-2024 programme starting in 2020. The main objectives of VESPA are to facilitate searches both in big archives and in small databases, to enable data analysis by providing simple data access and online visualization functions, and to allow research teams to publish derived data in an interoperable environment as easily as possible. VESPA encompasses a wide scope, including surfaces, atmospheres, magnetospheres and planetary plasmas, small bodies, heliophysics, exoplanets, and spectroscopy in solid phase. This system relies in particular on standards and tools developed for the Astronomy VO (IVOA) and extends them where required to handle specificities of Solar System studies. It also aims at making the VO compatible with tools and protocols developed in different contexts, for instance GIS for planetary surfaces, or time series tools for plasma-related measurements. An essential part of the activity is to publish a significant amount of high-quality data in this system, with a focus on derived products resulting from data analysis or simulations.

The aim was to create and study a possible behavioural measure for trait(s) in humans that reflect the ability and motivation to continue an unpleasant behaviour, i.e., behavioural perseverance or persistence (BP). We utilised six different tasks with 54 subjects to measure the possible BP trait(s): cold pressor task, hand grip endurance task, impossible anagram task, impossible verbal reasoning task, thread and needle task, and boring video task. The task performances formed two BP factors. Together, the two-factor solution is responsible for the common variance constituting 37.3% of the total variance in the performances i.e., performance times. Excluding the impossible anagram task, the performance in any given task was better explained by performances in the other tasks (i.e., “trait”, η2 range = 0.131–0.253) than by the rank order variable (“depletion”, i.e., getting tired from the previous tasks, η2 range = 0–0.096).

Abstract Background Prebiotics are non-digestible food ingredients that enhance the growth of certain microbes within the gut microbiota. Prebiotic consumption generates immune-modulatory effects that are traditionally thought to reflect microbial interactions within the gut. However, recent evidence suggests they may also impart direct microbe-independent effects on the host, though the mechanisms of which are currently unclear. Methods Kinome arrays were used to profile the host intestinal signaling responses to prebiotic exposures in the absence of microbes. Identified pathways were functionally validated in Caco-2Bbe1 intestinal cell line and in vivo model of murine endotoxemia. Results We found that prebiotics directly regulate host mucosal signaling to alter response to bacterial infection. Intestinal epithelial cells (IECs) exposed to prebiotics are hyporesponsive to pathogen-induced mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) activations, and have a kinome profile distinct from non-treated cells pertaining to multiple innate immune signaling pathways. Consistent with this finding, mice orally gavaged with prebiotics showed dampened inflammatory response to lipopolysaccharide (LPS) without alterations in the gut microbiota. Conclusions These findings provide molecular mechanisms of direct host-prebiotic interactions to support prebiotics as potent modulators of host inflammation.

The aim of the study was to assess patient dose from whole-body computed tomography (CT) in association with patient size, automatic exposure control (AEC) and intravenous (IV) contrast agent.

The conditions in Venus' upper mesosphere at around 120 km have some similarities to the upper mesosphere of Earth and Mars where ice clouds form. Here we show, using published satellite products and numerical modeling, that the upper mesosphere of Venus can be sufficiently cold that both H2O and CO2 may condense to form particles. We show that amorphous solid water particles (ASW) are likely to nucleate both heterogeneously on meteoric smoke and also homogeneously, resulting in clouds of nano‐scaled particles at around 120 km that will occur globally. The temperatures may then become sufficiently low, below ∼90 K, that CO2 particles can nucleate on ASW particles. Given the uncertainty associated with retrievals of temperature in the upper mesosphere, it is unclear how frequently this occurs, but it could be >30% of the time poleward of 60°. Since the main component of Venus' tenuous atmosphere is CO2, any CO2 crystals that form will grow and sediment on a timescale of 10–20 min. Mie calculations show that these Venusian mesospheric clouds (VMCs) should be observable by contemporary satellite instruments, although their short lifetime means that the probability of detection is small. We suggest that VMCs are important for the redistribution of meteoric smoke and may serve as a cold‐trap, removing some water vapor from the very upper mesosphere of Venus through the growth and sedimentation of cloud particles, and possibly reducing the loss of water to space. Plain Language Summary: Venus is renowned for extreme heat at the surface and clouds composed of sulfuric acid encircling the planet; however, there are regions of Venus's atmosphere that are sufficiently cold to harbor ice clouds. In fact, the temperatures frequently fall below 100 K at around 120 km altitude and under the right conditions, we have shown that ice clouds composed of both water and carbon dioxide ices can form. We have used published data from satellites that orbit Venus to show that clouds composed of nanometer sized water ice particles may encircle the planet. The temperatures are so low in this part of Venus' atmosphere that the ice in these water ice particles likely lacks any crystalline structure, i.e., it has an amorphous (liquid‐like) structure. Furthermore, if the temperature falls below about 90 K, we have shown that carbon dioxide ice crystals can form on top of water ice particles. Since the atmosphere of Venus is mainly made of carbon dioxide, these carbon dioxide crystals grow and then sediment rapidly in the thin atmosphere. If we were lucky enough to see one of these short‐lived sporadic clouds, it would look a bit like mares' tail cloud on Earth. Key Points: The upper mesosphere of Venus can be supersaturated with respect to both amorphous solid water (ASW) and crystalline carbon dioxide iceThere is a persistent layer of nano‐scale ASW particles encircling VenusShort‐lived carbon dioxide ice clouds may sporadically form in the upper mesosphere [ABSTRACT FROM AUTHOR]

Inkjet printing of spherical gold nanoparticles is widely applied in the fabrication of analytical and diagnostics tools. These methods could be extended to non-spherical gold nanoparticles that can efficiently release heat locally when irradiated in the near infrared (NIR) wavelength region, due to localized surface plasmon resonance (LSPR). However, this promising application requires the ability to maintain high efficiency and tunability of the NIR LSPR of the printed nanoparticles. In this study stable inks containing PEGylated gold nanostars (GNS) were fabricated and successfully inkjet-printed onto differently coated paper substrates with different porosity and permeability. A pronounced photothermal effect was observed under NIR excitation of LSPR of the printed GNS patterns even at low laser intensities. It was found that beside the direct role of the laser intensity, this effect depends appreciably on the printing parameters, such as drop density (δ, drops/mm2) and number of printed layers, and, critically, on the permeability of the coated paper substrates. These results will promote the development of GNS-based printed platforms for local photothermal therapy.

Understanding the relationship between psychological and physiological factors in depression and depressive symptoms may help us define depression subcategories based on their parasympathetic nervous system activity and reactivity, and perhaps in the future, develop more effective symptom-based treatments. In this study we aimed to shed light on the relationship between selected psychological traits (harm avoidance and self-rumination) and physiological stress (high-frequency heart rate variability, HF-HRV). We recruited 58 females to participate in a laboratory study where they completed a public speech preparation task designed to induce stress. We found that participants with higher scores in self-reported harm avoidance and self-rumination had lower HF-HRV during the stress task, indicating a parasympathetic withdrawal (i.e. more stress). The associations between self-reported depressive symptoms and HF-HRV were not statistically significant. Thus, we linked psychological depression risk factors to specific indices of higher physiological stress.