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77 results on '"M.C. Sighinolfi"'

56. Robotic surgical approach to partial nephrectomy – rather than renal mass complexity – is the main driver of shorter length of hospital stay: Results from a single center series

Author

M.C. Sighinolfi, L. Sarchi, B. Rocco, E. Morini, A. Cassani, and Simone Assumma

Subjects
medicine.medical_specialty, Series (stratigraphy), Surgical approach, business.industry, Urology, medicine.medical_treatment, medicine, Renal mass, business, Single Center, Hospital stay, Nephrectomy, Surgery
Published
2021
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75. Extracorporeal Shock Wave Lithotripsy in an Elderly Population How to Prevent Complications and Make the Treatment Safe and Effective.

Author

M.C. Sighinolfi, S. Micali, M. Grande, A. Mofferdin, S. De Stefani, and G. Bianchi

Subjects
*DISEASES, *DIAGNOSIS, *MEDICINE, *SICK leave, *SICK people
Abstract

IntroductionThe aim of our study is to consider the feasibility and the results of shock wave lithotripsy (SWL) in an elderly cohort of patients, considering different diseases and concomitant morbidity.Materials and MethodsFrom January 2003 up to July 2006, a total of 1100 SWL treatments were performed in our Stone Centre with Dornier Lithotripter S device. We retrospectively analyzed all the treatments carried out in patients older than 70 years of age, collecting a total of 130 patients. The average age was 75.1 years (range 70–89). Stone location was renal in 95 and ureteral in 45 patients. Information about SWL outcomes and complications were collected as well as patient's characteristics and treatment modalities.ResultsAverage stone size was 10.2 − 3.4 and 8.7 − 3.1 for the renal and ureteral location, respectively. 73 out of 140 patients (52.1) were stone free after a single treatment; 49 patients (35) required an adjunctive session, whereas SWL was unsuccessful in 18 (12.8) patients. We observed 64, 24, 21, 10, 31 cases of concomitant arterial hypertension, diabetes mellitus, chronic renal failure, solitary kidney condition and previous neoplastic pathologies. A total of 8 and 6 subjects had previous cardiac surgery and atrial fibrillation respectively, thus requiring a warfarin scheduled conversion to low molecular weight heparin. Five patients had a pace maker implant and three patients an abdominal aortic aneurism. No SWL-related complications were found in this series considering both urological and systemic features.ConclusionSWL represents the treatment of choice for urolithiasis, and it has to be recommended especially to geriatric patients. In those subjects, SWL complications can be avoided with a proper and personalized preparation, together with an ECG and ultrasound continuously monitored procedure. [ABSTRACT FROM AUTHOR]

Published
2008
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77. Retrospective descriptive analysis of the physiological kinetics of prostate-specific antigen in men older than 75 years

Author

Stefano De Stefani, Salvatore Micali, Marco Giacometti, F. Cianci, Giampaolo Bianchi, Arrigo F G Cicero, Maria Chiara Sighinolfi, M.C. Sighinolfi, S. Micali, S.D. Stefani, A. Cicero, F. Cianci, M. Giacometti, and G. Bianchi

Subjects
Male, medicine.medical_specialty, Epidemiology, Urology, urologic and male genital diseases, PSA, histones, Internal medicine, medicine, Humans, human sperm nucleus, Aged, Retrospective Studies, Gynecology, telomere, Psa kinetics, PSA Velocity, business.industry, Retrospective cohort study, Mean age, General Medicine, Prostate-Specific Antigen, Prostate-specific antigen, Psa test, Cohort, Original Article, business, protamine
Abstract

Several studies have compared prostate-specific antigen (PSA) kinetics in men with and without cancer, but there has been no adequate analysis of the longitudinal variation in PSA. The aim of this study was to assess the fluctuations in PSA in a cohort of elderly men in an attempt to define a physiological pattern of PSA kinetics. We searched a specific cohort of patients aged > 75 years and with PSA value < 2.0 ng mL(-1). A history of all PSA values over the past 10 years was compiled for each patient to create a database of patients fitting the following criteria: (1) minimum of five PSA measurements, (2) over at least 5 years. Exclusion criteria were: (1) PSA < 0.2 ng mL(-1) at each measurement and (2) having had more than one PSA test per year. In all, 1 327 patients (mean age: 78.52 years) fit the inclusion criteria. The mean variation from the first to the last PSA test was 0.05 +/- 0.43, with a mean follow-up of 6.79 +/- 1.71 years. Over the same period, the mean fluctuation from the lowest to the highest PSA value was 0.04 +/- 0.55 (P = 0.925). The mean annual PSA velocity (PSAV) was calculated by dividing the mean variation from the first to the last PSA test by the number of years of observation for each patient and was set at 0.0104 +/- 0.1050. Concluding, in a large-scale cohort of elderly individuals considered healthy and evaluated for a considerable follow-up, the average annual PSAV as well as the average fluctuation from the lowest to the highest PSA value are insignificant.

Published
2009
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