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56 results on '"Luz Caviedes"'

51. Aegicerin, the First Oleanane Triterpene with Wide-Ranging Antimycobacterial Activity, Isolated from Clavija procera

Author

Gerald B. Hammond, José C. Aponte, Rosario Rojas, Gerardo Lamas, César Sarasara, Walter H. Lewis, Luz Caviedes, Abraham Vaisberg, and Robert H. Gilman

Subjects
medicine.drug_class, Antitubercular Agents, Pharmaceutical Science, Microbial Sensitivity Tests, Antimycobacterial, Article, Analytical Chemistry, Mycobacterium tuberculosis, chemistry.chemical_compound, Triterpene, Drug Resistance, Multiple, Bacterial, Theophrastaceae, Chlorocebus aethiops, Drug Discovery, medicine, Animals, Oleanolic Acid, Vero Cells, Oleanane, Antibacterial agent, Pharmacology, chemistry.chemical_classification, Plants, Medicinal, biology, Traditional medicine, Organic Chemistry, respiratory system, bacterial infections and mycoses, biology.organism_classification, Triterpenes, Terpenoid, Complementary and alternative medicine, chemistry, Biochemistry, Molecular Medicine, Procera
Abstract

An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 microg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).

Published
2006
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52. Tovar et al. (2008; 46:909–12)

Author

Robert H. Gilman, Teresa Valencia, C. Santillan, Marco A. Tovar, Oswaldo Jave, Carlton A. Evans, Mark J. Siedner, Luz Caviedes, A. R. Escombe, and David Moore

Subjects
Microbiology (medical), Pathology, medicine.medical_specialty, Infectious Diseases, Pleural tuberculosis, business.industry, medicine, Drug susceptibility, business, Microscopic observation
Published
2008
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53. Hemoptysis as a warning sign of thoracic aorta pseudoaneurysm: A case report.

Author

Rodríguez-Hidalgo LA, Concepción-Urteaga LA, Hilario-Vargas JS, and Ruiz-Caballero DC

Subjects
Aged, 80 and over, Aneurysm, False complications, Aneurysm, False surgery, Aortic Aneurysm, Thoracic complications, Aortic Aneurysm, Thoracic surgery, Computed Tomography Angiography, Diagnosis, Differential, Hemoptysis diagnosis, Humans, Male, Tomography, X-Ray, Aneurysm, False diagnostic imaging, Aorta, Thoracic diagnostic imaging, Aortic Aneurysm, Thoracic diagnostic imaging, Aortic Rupture, Hemoptysis etiology
Abstract

Pseudoaneurysm is defined as a reperfused pulsatile hematoma, encapsulated and communicated with the damaged vessel's lumen. It originates when there is a disruption of the arterial wall. Hemoptysis is a very rare sign/symptom of a thoracic aortic aneurysm or pseudoaneurysm. There is little information on hemoptysis associated with aortic aneurysm rupture, whose mechanisms are not explained by the presence of an aortopulmonary fistula. Among the hypotheses to explain this phenomenon, is the ability of the bronchial arteries to become hyperplasic and tortuous in the presence of a lesion that modifies the pulmonary architecture, being more susceptible to rupture. There are also descriptions of direct lung parenchymal injury from ruptured aneurysm. The present case illustrates that we must consider the hemoptysis as a warning sign in differential diagnosis of aortic aneurysms and pseudo aneurysms, among other causes, that it can be fatal in a short time due to massive hemorrhage.

Published
2021
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54. A case report of tuberculous chylothorax.

Author

Rodríguez-Hidalgo LA, Concepción-Urteaga LA, Cornejo-Portella JL, Alquizar-Horna ON, Aguilar-Villanueva DA, Concepción-Zavaleta MJ, and Ruiz-Caballero DC

Subjects
Bronchoscopy, Chylothorax drug therapy, Chylothorax microbiology, Cough etiology, Dyspnea etiology, Humans, Male, Middle Aged, Peru, Tuberculosis, Pleural drug therapy, Antitubercular Agents administration & dosage, Chylothorax diagnosis, Pleural Effusion diagnosis, Tuberculosis, Pleural diagnosis
Abstract

Tuberculous chylothorax is a rare infectious disease that occurs when the thoracic duct is obstructed. Treatment is directed to the tuberculosis infection. A 55-year-old male, driver, born in Trujillo (Peru) is admitted to the emergency department with increasing dyspnea and a 5-day dry cough. The physical examination revealed vocal fremitus, dullness to percussion, and a vesicular murmur that was decreased on the lower 2/3 of the left hemithorax. The X-ray and the thoracic ultrasound revealed significant left pleural effusion. The thoracocentesis drained fluid identified as chylothorax. Subsequently, a thoracic tube was placed, with a decrease in pleural fluid volume and later normalization of the cytochemical changes. Diagnostic video bronchoscopy was performed with a bronchoalveolar aspirate, revealing acid-fast bacilli. The patient received antituberculosis treatment with a favorable outcome. Tuberculous chylothorax is an important cause of chylothorax to be considered in endemic areas of tuberculosis. Proper treatment of the infection leads to resolution of the disease.

Published
2019
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55. Pulmonary alveolar proteinosis: a case report.

Author

Concepción-Urteaga LA, Rodríguez-Hidalgo LA, Cornejo-Portella JL, Alquizar-Horna ON, Aguilar-Villanueva DA, Concepción-Zavaleta MJ, and Azañero-Luján MG

Subjects
Adult, Biopsy, Bronchoscopy methods, Cough etiology, Humans, Male, Pulmonary Alveolar Proteinosis diagnostic imaging, Pulmonary Alveolar Proteinosis physiopathology, Rare Diseases diagnosis, Rare Diseases diagnostic imaging, Rare Diseases physiopathology, Tomography, X-Ray Computed, Bronchoalveolar Lavage methods, Dyspnea etiology, Pulmonary Alveolar Proteinosis diagnosis
Abstract

Introduction: Pulmonary alveolar proteinosis is a rare, diffuse interstitial lung disease, characterized by alveolar obstruction due to the accumulation of pulmonary surfactant., Clinical Presentation: A 30-year-old male with progressively worsening dyspnea and non-productive cough for one year. He was a sugar cane plantation worker and had prior recurrent respiratory infections. Physical exam revealed cyanosis, and bilateral coarse and fine rales. Chest computed tomography showed diffuse crazy paving pattern. Bronchoscopy with bronchoalveolar lavage yielded a foamy, thick whitish material. Cytology revealed lymphocytes and acellular proteinaceous eosinophilic material. Transbronchial biopsy confirmed the diagnosis of pulmonary alveolar proteinosis. Patient met criteria for whole lung lavage, responding favorably to this therapy., Conclusion: Pulmonary alveolar proteinosis is a rare lung disease and important to consider due to the diagnostic and therapeutic challenge it represents.

Published
2017
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56. [Implementation of a telediagnostic system for tuberculosis and determination of multi-drug resistance based in the MODS method in Trujillo, Peru].

Author

Rodríguez L, Alva A, Coronel J, Caviedes L, Mendoza-Ticona A, Gilman R, Sheen P, and Zimic M

Subjects
Algorithms, Bacteriological Techniques, Diagnostic Imaging, Humans, Microbial Sensitivity Tests, Mycobacterium tuberculosis drug effects, Mycobacterium tuberculosis growth & development, Peru, Tuberculosis, Multidrug-Resistant diagnosis, Telemedicine, Tuberculosis diagnosis
Abstract

Objectives: To implement a system for remote diagnosis of tuberculosis and multidrug resistance (MDR) using the Microscopic-Observation Drug Susceptibility Assay (MODS) method in the Mycobacteria Laboratory, Trujillo Center of Excellence in Tuberculosis (CENEX-Trujillo). The system included a variant of an algorithm for recognition of Mycobacterium tuberculosis recently reported from digital images of MODS cultures of sputum samples., Materials and Methods: The recognition algorithm was optimized using a retraining statistical model based on digital images of MODS cultures from CENEX-Trujillo. Images of 50 positive MODS cultures of patients with suspected multidrug-resistant tuberculosis were obtained between January and October 2012 in the CENEX-Trujillo., Results: The sensitivity and specificity to recognize strings of tuberculosis were 92.04% and 94.93% respectively using objects. The sensitivity and specificity to determine a positive tuberculosis field were 95.4% and 98.07% respectively using pictures., Conclusions: The results demonstrated the feasibility of the implementation of telediagnostics in remote locations, which may contribute to the early detection of multidrug-resistant tuberculosis by MODS method.

Published
2014

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