77 results on '"Lu, Hai‐Xia"'
Search Results
52. The Building of Scenic Area Evaluation Index System on Low-Carbon Economy Perspective
- Author
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Li, Xiao Qin, primary, Yin, Yuan, additional, and Lu, Hai Xia, additional
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- 2012
- Full Text
- View/download PDF
53. Organotypic slices culture model for cerebellar ataxia: Potential use to study Purkinje cell induction from neural stem cells
- Author
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Lu, Hai-xia, primary, Levis, Hannah, additional, Liu, Yong, additional, and Parker, Terry, additional
- Published
- 2011
- Full Text
- View/download PDF
54. Neurotrophin-3 gene transduction of mouse neural stem cells promotes proliferation and neuronal differentiation in organotypic hippocampal slice cultures
- Author
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Lu, Hai-xia, primary, Hao, Zhi-ming, additional, Jiao, Qian, additional, Xie, Wu-ling, additional, Zhang, Jun-feng, additional, Lu, Yi-fei, additional, Cai, Min, additional, Parker, Terry, additional, and Liu, Yong, additional
- Published
- 2011
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55. Assessing consistency in oral health-related quality of life (OHRQoL) across gender and stability of OHRQoL over time for adolescents using Structural Equation Modeling
- Author
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Wong, May C. M., primary, Lau, Abby W. H., additional, Lam, K. F., additional, McGrath, Colman, additional, and Lu, Hai-Xia, additional
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- 2010
- Full Text
- View/download PDF
56. Effects of ultra-high pressure on gel properties of big head croaker (Collichthys lucidus) surimi
- Author
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HU, Fei-hua, primary, LU, Hai-xia, additional, CHEN, Qing, additional, and LI, Jian-rong, additional
- Published
- 2010
- Full Text
- View/download PDF
57. Toxin-produced Purkinje cell death: A model for neural stem cell transplantation studies
- Author
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Lu, Hai-xia, primary, Levis, Hannah, additional, Melhem, Nabil, additional, and Parker, Terry, additional
- Published
- 2008
- Full Text
- View/download PDF
58. Effectiveness of 3 different methods in prevention of dental caries in permanent teeth among children.
- Author
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TANG Li-hong, SHI Le, YUAN Shuang, LV Jin, and LU Hai-xia
- Published
- 2014
59. Multiple factors analysis of periodontal status in pregnant women in Shanghai.
- Author
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CHEN Lin, LU Hai-xia, WEI Tian-you, and FENG Xi-ping
- Published
- 2014
60. Low concentration of serum helps to maintain the characteristics of NSCs/NPCs on alkali-treated PHBHHx film in vitro.
- Author
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Lu, Hai-xia, Yang, Zhi-qian, Jiao, Qian, Wang, Yuan-yuan, Wang, Li, Yang, Peng-bo, Chen, Xin-lin, Zhang, Peng-bo, Wang, Peng, Chen, Ming-xia, Lu, Xiao-yun, and Liu, Yong
- Subjects
SERUM ,NEURAL stem cells ,PROGENITOR cells ,CELL differentiation ,CELL proliferation - Abstract
Objective: Efforts have been made by tissue engineers to create a permissive environment for neural regeneration, and to enhance the efficiency of neural stem cell (NSC) transplantation. However, to acquire sufficient number of seed cells on the material appears to be the main obstacle to constructing functional transplantable NSC-biomaterial complexes. A culture system has been optimized in the current study to maintain the specific characteristics of NSCs/neural progenitor cells (NPCs) on the material and achieve sustaining increased multipotent seed cells. Methods: The PHBHHx film was selected as biomaterial and the surface was firstly modified with NaOH treatment. The NSCs/NPCs isolated from the cerebral cortex of rat embryos were cultured on the treated PHBHHx films in growth medium containing 1%, 5%, and 10% fetal bovine serum (FBS). Then the attachment, survival, proliferation, and differentiation of NSCs/NPCs were assessed. Results: NaOH treatment significantly increased the hydrophilicity of PHBHHx and enhanced NSCs/NPCs attachment. On the treated PHBHHx film, NSCs/NPCs survived well and actively proliferated in the medium containing 1% FBS. After 7-14 days in culture, approximately two-thirds of cells remained as nestin and Sox2 positive NSCs/NPCs. However, in the medium containing 5% and 10% FBS, NSCs/NPCs proliferation was reduced and differentiation, particularly glial differentiation was significantly promoted. Conclusion: Growth medium containing low concentration of FBS is favorable for maintaining the characteristics, in terms of self-renewal and multiple differentiation, of NSCs/NPCs on NaOH-treated PHBHHx films. This could be a useful method to construct functional transplantable NSCs/NPCs-biomaterial complex. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
61. Effects of growing conditions on the electric and magnetic properties of strained La2/3Sr1/3MnO3 thin films.
- Author
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Lu Hai-Xia, Wang Jing, Shen Bao-Gen, and Sun Ji-Rong
- Subjects
- *
THIN film research , *ELECTRIC properties of thin films , *MAGNETIC properties of thin films , *ELECTRICAL resistivity , *CURIE temperature - Abstract
We investigate the growing condition dependences of magnetic and electric properties of the La2/3Sr1/3MnO3 thin films grown on SrTiO3 (001) substrates. With reducing the film thickness and growth pressure, the Curie temperature (TC) drops off, and the magnetism and metallicity are suppressed. At an appropriate deposition temperature, we can obtain the best texture and remarkably enhance the magnetic and electrical properties. However, the resistivity of film cannot be modulated by changing the dc current and green light intensity. This result may be induced by the coherent strains in the epitaxially grown film due to its lattice mismatching that of the SrTiO3 substrate. Furthermore, we show that the relations between the magnetism and the resistivity for the typical films with different thickness values. For the 13.4-nm-thick film, the R–T curve presents two transition behaviors: insulator-to-metal and metal-to-insulator in the cooling process: the former corresponds to magnetic transition, and the later correlates with thermal excitation conduction. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
62. [Investigation and analysis of the current situation of dental technical professionals in Shanghai medical institutions].
- Author
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Zhou YH, Lu HX, Wang L, and Jin LH
- Subjects
- Humans, China, Dental Staff, Oral Medicine education
- Abstract
Purpose: To investigate the current situation of dental technical personnel team in medical institutions in Shanghai, and to provide reference for the construction of dental technical discipline and development of dental personnel team in the National Center for Stomatology (Shanghai)., Methods: Random sample questionnaire and expert interviews were used to find out the awareness, satisfaction and improvement suggestions of dental technicians among physicians, nursing and medical technicians in medical institutions in Shanghai., Results: Among the positions engaged in by dental technicians, dental prosthetic technician, dental radiology technician and laboratory technician were the three most important positions at present, 62.3% of doctors and nurses were satisfied with the work of dental technicians, while 56.2% of dental medical technicians were generally or relatively unsatisfied with their current work., Conclusions: It is necessary to increase training and education opportunities for dental technicians, improve the talent echelon, introduce high-level talents, improve the working environment and treatment, broaden promotion channels, strengthen communication and exchange with medical care, and build a first-class medical technical personnel team that is compatible with the clinical level of stomatology.
- Published
- 2023
63. [The effect of chronic kidney disease on periodontitis-related microorganisms in mice].
- Author
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Ma XX, Duan SZ, Feng XP, Zhang ZY, Xu W, and Lu HX
- Subjects
- Animals, Male, Maxilla pathology, Mice, Mice, Inbred C57BL, Alveolar Bone Loss, Periodontitis, Renal Insufficiency, Chronic pathology
- Abstract
Purpose: To explore the effect of chronic kidney disease on the composition of oral microbial community in mice and find the significant species., Methods: Twenty C57BL/6 male mice were randomly divided into 4 groups: healthy control group (HC), periodontitis group (PD), chronic kidney disease group (CKD) and chronic kidney disease and periodontitis group (CKD+PD). The periodontitis model was created in the fourth week when the chronic kidney disease model was established, and then the mice were sacrificed in the sixth week. Histopathological analysis of the kidney was performed by H-E staining and Masson's trichrome staining. Alveolar bone resorption of maxilla was analyzed by micro-CT analysis. The third-generation full-length sequencing of 16SrRNA gene was used to analyze the composition of oral microbial community among groups. Statistical analysis was performed using SPSS 24.0 software package., Results: There were significant differences in alveolar bone resorption, the richness of species and the overall composition of the microbial community among the four groups (P<0.001). In CKD group, Streptococcus azizii had the most significant abundance. Escherichia coli was the most significantly different species among identifiable bacteria in CKD+PD group, while Staphylococcus lentus and Lactobacillus murinus were species with the most significant differences in HC group and PD group, respectively., Conclusions: The composition of the oral microbial community was significantly different among four groups with significant species.
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- 2021
64. [Investigation and analysis on the status of conducting clinical research among oral health professionals].
- Author
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Huang C, Shi CJ, Chen R, Zhang ZY, Xu F, and Lu HX
- Subjects
- China, Humans, Surveys and Questionnaires, Oral Health
- Abstract
Purpose: To understand oral health professionals' knowledge, attitude, behavior and training needs related to clinical research, and explore relevant factors affecting clinical research knowledge level., Methods: An online self-designed questionnaire was conducted among oral health professionals from the collaborative innovation network member units of the National Clinical Research Center for Oral Diseases (Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine). The data were processed with SAS 9.4 software package., Results: A total of 281 oral health professionals were enrolled in the study. Most of them had a positive attitude towards clinical research, 80% of them had an idea of carrying out clinical research, while only 22.8% of them implemented finally. The main causes restricting oral health professionals from conducting clinical research were lack of time (68.3%), insufficient teams (63.7%), and short of financial support (60.9%). Participants' mean score of clinical research knowledge was (13.72±7.20) points. Multiple linear regression model showed the type of hospital, clinical research participation in the past five years and epidemiologists' or statisticians' involvement in the latest project were related to participants' knowledge level of clinical research., Conclusions: Oral health professionals have a positive attitude towards clinical research, while their behavior and knowledge about clinical research were weak. Strengthening the top design of clinical research is inseparable from the cultivation of professionals' clinical research ability. The national clinical research center should give full play to the mission of the "national team", accelerate the establishment of a specialized, normalized and large-scale clinical research training pattern, and provide training opportunities to network member units.
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- 2021
65. [Characteristics of clinical trials of mucosal melanoma registered in WHO ICTRP].
- Author
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Shi CJ, Huang C, Chen R, Zhou R, Xu F, Han Y, Xu SM, Li CW, Lu HX, and Zhang ZY
- Subjects
- Databases, Factual, Humans, Registries, World Health Organization, Melanoma
- Abstract
Purpose: To analyze the characteristics of clinical trials of mucosal melanoma (MM) based on WHO international clinical trial registration platform (ICTRP), in order to provide a reference for clinical translational research of mucosal melanoma., Methods: WHO ICTRP database were searched to collect MM-related clinical trials. Two reviewers independently screened items, extracted data, and descriptive analysis was performed for the included trials, including number of registrations, research phase, country/region, clinical study design, etc. RESULTS: The results showed that there were 51 registered clinical trials involving MM. European and American countries and East Asia were the main study sites, and head and neck MM were mainly investigated in East Asia (11/12). Forty-eight of them were sponsored by investigators, and only 3 were sponsored by biomedical companies. The main clinical trials were single center (42 items) and in stage II (38 items). Interventions were complex, and multiple treatments and drug therapy accounted a dominant position., Conclusions: In-depth analysis of clinical trials information can help to understand the current situation and development trends in the field of mucosal melanoma. The number of clinical studies of mucosal melanoma is relatively small and has not received much attention.
- Published
- 2021
66. Prevalence and Associated Factors of Tooth Wear in Shanghai.
- Author
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Yu T, Tao DY, Lu HX, Zhu JL, Xie CY, Bartlett D, and Feng XP
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- Adolescent, Adult, Child, China, Cross-Sectional Studies, Humans, Prevalence, Risk Factors, Tooth Erosion, Tooth Wear
- Abstract
Objective: To estimate the prevalence and distribution of tooth wear among groups of adolescents and adults in Shanghai, China through an epidemiological survey, and explore the associated factors., Methods: Multistage, stratified, constant volume and cluster sampling methods were used in an epidemiological survey conducted in Shanghai in 2014. The basic erosive wear examination (BEWE) index was used to screen for tooth wear in different age groups: 12 years, 15 years, 18 to 35 years, 36 to 49 years and 50 to 74 years. A previously published questionnaire collected information including dietary habits, oral hygiene habits and general conditions., Results: This survey reports the results for 1806 participants in Shanghai. The prevalence of tooth wear was 59.7% in adolescents (BEWE ≥ 1) and 93.1% in adults (BEWE ≥ 2). The prevalence and severity of disease increased with age (P < 0.01). The teeth most susceptible to wear were the central incisors and first molars. Multivariate analysis of covariance (ANCOVA) results showed that soft drinks, alcoholic drinks, pickled vegetables and hard food, gastroesophageal reflux disease (GERD), xerostomia and poor tooth brushing habits were statistically correlated with tooth wear in different age groups., Conclusion: The prevalence of tooth wear appears to be high in adolescents and adults in Shanghai. Frequent consumption of soft or alcoholic drinks, GERD, xerostomia and poor tooth brushing habits were positively associated with tooth wear in different age groups.
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- 2021
- Full Text
- View/download PDF
67. [Instructions for clinical research of oral diseases under the first level response to public health emergencies].
- Author
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Huang C, Shi CJ, Xu F, Zhen H, Lu HX, and Zhang ZY
- Subjects
- Betacoronavirus, COVID-19, China, Clinical Trials as Topic, Humans, SARS-CoV-2, Coronavirus Infections, Emergencies, Mouth Diseases therapy, Pandemics, Pneumonia, Viral, Public Health
- Abstract
Corona virus disease 2019(COVID-19) has swept across our country and local governments have successively initiated first level response to public health emergencies. The outbreak of COVID-19 poses a huge challenge to the implementation of various clinical researches including oral diseases. In view of the specialty of oral diseases, it is particularly necessary to protect the health and rights of the participators and related practitioners, and to standardize the implementation of clinical trials. Based on the normative standards issued by the National Health Commission of China, consensus on clinical trial management formulated by the organization of clinical research, and regulations for the diagnosis and treatment of oral diseases during public health emergencies by Chinese Stomatological Association, we drafted the guideline for clinical research of oral diseases, with a view to provide reference for the clinical studies of oral diseases under the first level response to major public health emergencies.
- Published
- 2020
68. [A comparative study of the relationship of mothers' and infants' risk of dental caries between Shanghai and Kunming].
- Author
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Bi C, Zhuo WJ, Meng M, Li YP, Lu HX, and Han XL
- Subjects
- Child, China, Female, Humans, Infant, Mothers, Pregnancy, Surveys and Questionnaires, Dental Caries, Dental Plaque
- Abstract
Purpose: To compare the differences of influence of mothers' different socio-demographic background, their oral health status and feeding behavior on their one-month-old infants' risk of dental caries between Shanghai and Kunming, and to explore the factors affecting infants' risk of dental caries in different regions., Methods: One-month-old infants and their mothers from Huangpu district of Shanghai and Xishan district of Kunming were recruited in the study. Oral plaque samples of mothers and their infants were collected to assess their risk of dental caries. Statistical analysis was performed using SPSS 22.0 software package, and multivariate logistic regression analysis was used to screen the factors affecting the risk of infantile rickets in Shanghai and Kunming., Resulits: A total of 165 mother-child pairs in Shanghai and 161 mother-child pairs in Kunming participated in the survey, and the proportion of infants who were at high risk of caries was 10.3% and 6.2%, respectively. The result of multivariate logistic analysis indicated that the infants whose mother smoked before pregnancy (OR=6.9, P=0.030) and attained lower education level (OR=6.1, P=0.035) had higher risk of caries in Shanghai; while in Kunming, the infants whose mother had higher DMFS values were at higher risk of caries (OR=1.1, P=0.031)., Conclusions: Factors affecting one-month-old infants' risk of caries in Shanghai and Kunming were pre-pregnancy maternal cigarette smoking, mother's lower education level and mother's dental caries status, respectively.
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- 2020
69. The 4th National Oral Health Survey in the Mainland of China: Background and Methodology.
- Author
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Lu HX, Tao DY, Lo ECM, Li R, Wang X, Tai BJ, Hu Y, Lin HC, Wang B, Si Y, Wang CX, Zheng SG, Liu XN, Rong WS, Wang WJ, and Feng XP
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, China epidemiology, DMF Index, Dental Health Surveys, Female, Humans, Male, Middle Aged, Mouth Mucosa, Oral Health, Periodontal Index, Dental Caries epidemiology, Dental Prosthesis statistics & numerical data, Fluorosis, Dental epidemiology, Mouth Diseases epidemiology, Periodontal Diseases epidemiology
- Abstract
Oral disease patterns change over time and it is important to conduct epidemiological surveillance population surveys regularly to monitor the situation. The overall objectives of the present survey were: (1) to describe the oral health status of Chinese children and adults in the 2015-2016 4th National Oral Health Survey; (2) to investigate the oral health knowledge, attitudes, and behaviours among children and adults; (3) to explore the association among sociodemographic characteristics, oral health behaviours, and the oral health status of Chinese children and adults. A national oral health survey was conducted among a representative sample of Chinese children and adults. Local residents from the five age groups - 3 to 5 years, 12 to 15 years, 35 to 44 years, 55 to 64 years, and 65 to 74 years - were selected. A multi-stage cluster sampling method was adopted for the identification of participants. All 31 provinces, autonomous regions and municipalities of the mainland of China were included. All participants were clinically examined and information on their oral health status, including oral mucosal lesions, dental caries experience, periodontal health status, dental fluorosis, and dental prosthesis status, was collected according to the procedures and criteria recommended by the World Health Organization (WHO). A calibration training programme and quality control procedures were conducted to ensure the reliability of the findings. Information on sociodemographic background, oral health behaviours, knowledge and attitude was also collected from all five age groups through a questionnaire survey.
- Published
- 2018
- Full Text
- View/download PDF
70. Identification of miR-101-3p targets and functional features based on bioinformatics, meta-analysis and experimental verification in hepatocellular carcinoma.
- Author
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Li CY, Pang YY, Yang H, Li J, Lu HX, Wang HL, Mo WJ, Huang LS, Feng ZB, and Chen G
- Abstract
Background: MiR-101-3p has been reported to suppress invasion and metastasis in hepatocellular carcinoma (HCC) cells. However, the relevant mechanisms are still unclear. The research seeks to determine systematic value of miR-101-3p in HCC, and comprehensively summarize the predicted target genes as well as their potential function, pathways and networks in HCC., Methods: The miR-101-1 profiles in 353 HCC patients from The Cancer Genome Atlas (TCGA) were analyzed. Meta-analysis was performed to estimate relationship of miR-101 (including precursor and mature miR-101) with clinical features and prognosis in HCC. Further, the promising targets of miR-101-3p were predicted and followed with Gene Ontology (GO), pathway and network analysis. In addition, the functional impact of miR-101-3p was confirmed with in vitro experiments in HCC cells., Results: In TCGA data, low-expression of miR-101-1 might be a diagnostic (AUC: 0.924, 95% CI: 0.894-0.953) and prognostic (HR=1.55) marker for HCC. Down-regulated miR-101-1 also correlated with poor differentiation, advanced TNM stage, lymph node metastasis and high AFP level of HCC. Meta-analysis revealed that miR-101 down-regulation were associated with poor prognosis, high AFP level and advanced TNM stage of HCC. Moreover, 343 hub genes were filtered and miR-101-3p may be involved in intracellular signaling cascade, transcription, metabolism and cell proliferation. Focal adhesion and pathways in cancer were also significantly enriched. In vitro experiments demonstrated that miR-101-3p inhibited proliferation and promoted apoptosis in HCC cells., Conclusions: MiR-101-1 may be a prospective biomarker for diagnosis and prognosis of HCC. Potential targets of miR-101-3p could regulate genesis and development of HCC. The data offers insights into biological significances and promising targets of miR-101-3p for further investigation and potential therapies in HCC., Competing Interests: None.
- Published
- 2017
71. [A survey on knowledge, attitude and practice related to evidence-based dentistry among dental students].
- Author
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Chang ZF, Zhu C, Tao DY, Feng XP, and Lu HX
- Subjects
- Attitude of Health Personnel, China, Dentistry, Evidence-Based Medicine, Humans, Internship and Residency, Surveys and Questionnaires, Evidence-Based Dentistry, Health Knowledge, Attitudes, Practice, Students, Dental
- Abstract
Purpose: To investigate the knowledge, attitude and practice related to evidence-based dentistry among dental students, and to provide a reference for targeted evidence-based dentistry teaching and practice evidence-based dentistry in dental students., Methods: Dental students who attended the internship in Shanghai Ninth People's Hospital and Pudong People's Hospital were invited to attend this survey. Information on knowledge, attitude and practices related evidence-based dentistry was collected through questionnaires. SPSS 21.0 software package was used for data analysis., Results: A total of 62 dental students attended this survey. Evidence-based dentistry related knowledge and attitude scores were 5.5±1.9 and 5.1±1.0, respectively. Over three quarters of students took courses on evidence-based medicine, while around half of students (56.5%) self-reported that they knew little about evidence-based medicine. 70.5% students practiced evidence-based dentistry less than once in the process of clinical decision making per week. The majority of students (80.3%) used MEDLINE or other databases to search for practice-related literature less than once per week. 63.9% students used practice guideline. The top three barriers to practice evidence-based dentistry were lack of information resources, insufficient time and lack of search skills., Conclusions: Evidence-based dentistry related knowledge and practice among dental students is deficient, whereas they hold positive attitude on practice. The top three barriers to practice evidence-based dentistry are lack of information resources, insufficient time and lack of search skills.
- Published
- 2017
72. [A study about oral health-related quality of Life among 11-14 years old children in Shanghai municipality].
- Author
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Cao YT, Zhu C, Xu W, Lu HX, and Ye W
- Subjects
- Adolescent, Child, China, Dental Care, Dental Caries, Health Education, Dental, Humans, Mouth Diseases, Periodontal Diseases, Quality of Life, Surveys and Questionnaires, Oral Health
- Abstract
Purpose: To assess oral health-related quality of life (OHRQoL) among 11-14 years old children in Shanghai municipality and investigate the influential factors, in order to provide theoretical evidence for pointed oral health education and public health strategies formulation., Methods: Systematic sampling method was used to extract 11-14 years old children in Shanghai municipality. The decay missing filling tooth (DMFT) and gingival bleeding index (GBI) were examined and recorded. Child oral-health-related quality of life questionnaires (CPQ11-14) was adopted to assess the OHRQoL. Other enquiry included sociodemographic background and oral health-related behaviors, knowledge and attitudes. Statistical analysis was performed using SPSS 21.0 software package., Results: This study examined 1050 children of 11-14 years old, among which 955 children (urban 482,suburb 473) were enrolled. The response rate was 91%. The mean CPQ11-14 score was (6.0±5.6). Statistical analysis showed that children with higher DMFT index and bleeding on probing had higher CPQ11-14 average score and poorer oral health related quality of life (P<0.05)., Conclusions: Caries and periodontal disease have negative effect on OHRQoL of 11-14 years old children. Efforts are needed to strengthen oral health care, including good oral health education, and focusing on halitosis and oral mucosal diseases in children aged 11-14 years old. Supported by Natural Science Foundation of Shanghai Municipality (12ZR1446100).
- Published
- 2015
73. [Effectiveness of 3 different methods in prevention of dental caries in permanent teeth among children].
- Author
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Tang LH, Shi L, Yuan S, Lv J, and Lu HX
- Subjects
- Child, Dentition, Permanent, Fluorides, Humans, Molar, Phosphates, Dental Caries prevention & control, Pit and Fissure Sealants
- Abstract
Purpose: To compare the effectiveness of fluoride vanish, fluoride foam, pit and fissure sealant with fluoride in prevention of dental caries, and investigate appropriate approach to prevent dental caries at schools., Methods: A randomized controlled clinical trial with 4 parallel groups was conducted. Totally 1016 children from 4 schools and 33 classes with a mean age of 7 to 8 years were included. They were randomly allocated into 4 groups: (1) fluoride vanish, semi-annual application; (2) fluoride foam, semi-annual application; (3) resin sealant, single placement; and (4) placebo control with oral hygiene instruction. Follow-up examinations were conducted after 2 years to monitor dental caries increment of first molars among these children. Data analysis was performed using SPSS 18.0 software package., Results: Two years later, 977 children (96.2%) were examined. The results of multiple factor ANCOVA showed that fluoride vanish and resin sealant had significantly lower mean dental caries increment on tooth surface compared with control group (P<0.05). No significant difference of mean dental caries increment on tooth surface was found between fluoride foam and control group (P>0.05)., Conclusions: The placement of resin sealant with fluoride and annual application of fluoride protector are effective in prevention of dental caries in permanent teeth of children.
- Published
- 2014
74. [Multiple factors analysis of periodontal status in pregnant women in Shanghai].
- Author
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Chen L, Lu HX, Wei TY, and Feng XP
- Subjects
- Adult, China, Cross-Sectional Studies, Female, Gingivitis, Humans, Logistic Models, Periodontitis, Pregnancy, Prevalence, Young Adult, Dental Plaque Index, Periodontal Diseases, Pregnancy Complications
- Abstract
Purpose: To assess the periodontal health status of pregnant women in Shanghai, and to investigate the factors that may influence the periodontal health status of pregnant women, in order to provide theoretical evidence for the pointed oral health education and public health strategies in future., Methods: A cross-sectional study was carried out to recruit pregnant women (0 to 40 weeks) randomly selected from primary Maternal and Child Care Service Centers in Shanghai. The data collection included the questionnaire survey and clinical periodontal examination. Visible plaque index (VPI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) were assessed during the clinical examination. Chi-square test and logistic regression analysis were performed to analyze the data by SPSS 18.0 software package., Results: A total of 561 pregnant women were surveyed. The mean age was (27.5 ± 4.0) years. The mean gestational age was (18.9 ± 8.1) weeks, ranged from 5 to 40 weeks. The prevalence of periodontal disease during pregnancy was 49.6%, of which the prevalence of gingivitis and periodontitis were 42.8% and 6.8%, respectively. The results of multiple logistic regression showed that pregnant women who were in the second and third trimesters, and whose place of residence was rural were significantly more likely to suffer periodontal disease., Conclusions: Gestational age and place of residence are the factors that are associated with the prevalence of periodontal disease among pregnant women in Shanghai. More oral health education and promotion should be targeted on these pregnant women at high-risk.
- Published
- 2014
75. [Salidroside protects cultured rat subventricular zone neural stem cells against hypoxia injury by inhibiting Bax, Bcl-2 and caspase-3 expressions].
- Author
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Qi C, Zhang J, Chen X, Zhang J, Yang P, Jiao Q, Zhang P, Lu HX, and Liu Y
- Subjects
- Animals, Cell Hypoxia, Cells, Cultured, Flow Cytometry, Rats, Rats, Sprague-Dawley, Caspase 3 metabolism, Glucosides pharmacology, Neural Stem Cells drug effects, Phenols pharmacology, Proto-Oncogene Proteins c-bcl-2 metabolism, bcl-2-Associated X Protein metabolism
- Abstract
Objective: To explore the effects of salidroside (sal) on the expressions of Bcl-2, Bax and caspases-3 proteins in cultured rat subventricular zone (SVZ) neural stem cells (NSCs) exposed to hypoxia injury., Methods: Primarily cultured SVZ NSCs from adult SD rats were incubated with salidroside (120 and 240 µmol/L) for 24 h prior to exposure to hypoxia. The cell viability was assessed with MTT assay, and the cell apoptosis was analyzed using TUNEL staining and flow cytometry. Western blotting was performed to detect the expressions of Bcl-2, Bax and caspase-3 in the cells., Results: Salidroside pretreatment of the cells for 24 h resulted in an obvious resistance to hypoxia-induced cell apoptosis and decrement of cell viability (P<0.05). Salidroside also antagonized the effect of hypoxia exposure in lowering Bcl-2/Bax ratio apoptosis of rat neural stem cells and decreased the expression of caspases-3 protein (P<0.05)., Conclusion: Salidroside can significantly resist hypoxia-induced. The neuroprotective effect of salidroside may be related to the modulation of expressions of apoptosis-related proteins.
- Published
- 2013
76. Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction.
- Author
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Jin H, Liu T, Wang WX, Xu JH, Yang PB, Lu HX, Sun QR, and Hu HT
- Subjects
- Alzheimer Disease metabolism, Alzheimer Disease physiopathology, Amyloid beta-Peptides toxicity, Animals, Apoptosis drug effects, Apoptosis physiology, Apoptosis Regulatory Proteins drug effects, Apoptosis Regulatory Proteins metabolism, Cell Survival drug effects, Cell Survival physiology, Cytoprotection drug effects, Cytoprotection physiology, Energy Metabolism drug effects, Energy Metabolism physiology, Intracellular Signaling Peptides and Proteins therapeutic use, Membrane Potentials physiology, Metabolic Networks and Pathways drug effects, Metabolic Networks and Pathways physiology, Mitochondria drug effects, Mitochondria metabolism, Mitochondrial Diseases metabolism, Mitochondrial Diseases physiopathology, Nerve Degeneration metabolism, Nerve Degeneration physiopathology, Neuroprotective Agents therapeutic use, PC12 Cells, Peptide Fragments antagonists & inhibitors, Peptide Fragments toxicity, Rats, Alzheimer Disease drug therapy, Amyloid beta-Peptides antagonists & inhibitors, Intracellular Signaling Peptides and Proteins pharmacology, Mitochondrial Diseases drug therapy, Nerve Degeneration drug therapy, Neuroprotective Agents pharmacology
- Abstract
Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD), and is considered as an early event in AD pathology. Humanin (HN) and its derivative, [Gly14]-Humanin (HNG), are known for their ability to suppress neuronal death induced by AD-related insults in vitro and in vivo. In the present study, we investigated the neuroprotective effects of HNG on Abeta(25-35)-induced toxicity and its potential mechanisms in PC12 cells. Exposure of PC12 cells to 25 microM Abeta(25-35) caused significant viability loss and cell apoptosis. In addition, decreased mitochondrial membrane potential and increased cytochrome c releases from mitochondria were also observed after Abeta(25-35) exposure. All these effects induced by Abeta(25-35) were markedly reversed by HNG. Pretreatment with 100 nM HNG 6h prior to Abeta(25-35) exposure significantly elevated cell viability, reduced Abeta(25-35)-induced cell apoptosis, stabilized mitochondrial membrane potential, and blocked cytochrome c release from mitochondria. Furthermore, HNG also ameliorated the Abeta(25-35)-induced Bcl-2/Bax ratio reduction and decreased caspase-3 activity in PC12 cells. These results demonstrate that HNG could attenuate Abeta(25-35)-induced PC12 cell injury and apoptosis by preventing mitochondrial dysfunction. Furthermore, these data suggest that mitochondria are involved in the protective effect of HNG against Abeta(25-35)., (Copyright (c) 2009 Elsevier Ltd. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
77. [A case-control study on the association of hepatocellular carcinoma with genetic polymorphisms of CYP3A5 in a highly aflatoxin B1 contaminated Guangxi area].
- Author
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Lu HX, Feng ZB, and Feng XL
- Subjects
- Adult, Carcinoma, Hepatocellular epidemiology, Case-Control Studies, China epidemiology, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Aflatoxin B1, Carcinoma, Hepatocellular genetics, Cytochrome P-450 CYP3A genetics, Food Contamination
- Published
- 2007
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