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321 results on '"Loop, Torsten"'

53. Extracorporeal membrane oxygenation: a ten-year experience

Author

Mols, Georg, Loop, Torsten, Geiger, Klaus, Farthmann, Edward, and Benzing, Albert

Subjects
Blood oxygenation, Extracorporeal -- Evaluation, Acute respiratory distress syndrome -- Care and treatment, Health
Published
2000

59. Additional file 2: of Protocol based evaluation for feasibility of extubation compared to clinical scoring systems after major oral cancer surgery safely reduces the need for tracheostomy: a retrospective cohort study

Author

Schmutz, Axel, Dieterich, Rolf, Kalbhenn, Johannes, Voss, Pit, Loop, Torsten, and Heinrich, Sebastian

Abstract

Details of the evaluated clinical scoring systems (shows the parameters of each of the evaluated scoring systems). (DOCX 17 kb)

Published
2018
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60. Additional file 1: of Protocol based evaluation for feasibility of extubation compared to clinical scoring systems after major oral cancer surgery safely reduces the need for tracheostomy: a retrospective cohort study

Author

Schmutz, Axel, Dieterich, Rolf, Kalbhenn, Johannes, Voss, Pit, Loop, Torsten, and Heinrich, Sebastian

Abstract

Additional statistical analysis (shows univariate and multivariate Analysis of potential risk factors for tracheostomy). (DOCX 20 kb)

Published
2018
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69. Deutsches Thoraxregister – Implementierung eines etablierten Werkzeugs der perioperativen Versorgungsforschung

Author

Defosse, Jérôme, additional, Schieren, Mark, additional, Loop, Torsten, additional, Arndt, Cerstin, additional, Röhrig, Rainer, additional, Stoelben, Erich, additional, Ludwig, Corinna, additional, Schleppers, Alexander, additional, Wappler, Frank, additional, Gerbershagen, Mark, additional, and Lopez-Pastorini, Alberto, additional

Published
2017
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70. Argon Mediates Anti-Apoptotic Signaling and Neuroprotection via Inhibition of Toll-Like Receptor 2 and 4

Author

Ulbrich, Felix, Kaufmann, Kai, Roesslein, Martin, Wellner, Franziska, Auwärter, Volker, Kempf, Jürgen, Loop, Torsten, Buerkle, Hartmut, and Goebel, Ulrich

Subjects
Caspase 3, MAP Kinase Signaling System, Apoptosis, Neuroprotection, Toll-Like Receptor 2, Toll-Like Receptor 4, Neuroblastoma, Neuroprotective Agents, Cell Line, Tumor, Rotenone, Humans, Argon, Phosphorylation, Research Article, Signal Transduction
Abstract

Purpose Recently, the noble gas argon attracted significant attention due to its neuroprotective properties. However, the underlying molecular mechanism is still poorly understood. There is growing evidence that the extracellular regulated kinase 1/2 (ERK1/2) is involved in Argon´s protective effect. We hypothesized that argon mediates its protective effects via the upstream located toll-like receptors (TLRs) 2 and 4. Methods Apoptosis in a human neuroblastoma cell line (SH-SY5Y) was induced using rotenone. Argon treatment was performed after induction of apoptosis with different concentrations (25, 50 and 75 Vol% in oxygen 21 Vol%, carbon dioxide and nitrogen) for 2 or 4 hours respectively. Apoptosis was analyzed using flow cytometry (annexin-V (AV)/propidiumiodide (PI)) staining, caspase-3 activity and caspase cleavage. TLR density on the cells’ surface was analyzed using FACS and immunohistochemistry. Inhibition of TLR signaling and extracellular regulated kinase 1/2 (ERK1/2) were assessed by western blot, activity assays and FACS analysis. Results Argon 75 Vol% treatment abolished rotenone-induced apoptosis. This effect was attenuated dose- and time-dependently. Argon treatment was accompanied with a significant reduction of TLR2 and TLR4 receptor density and protein expression. Moreover, argon mediated increase in ERK1/2 phosphorylation was attenuated after inhibition of TLR signaling. ERK1/2 and TLR signaling inhibitors abolished the anti-apoptotic and cytoprotective effects of argon. Immunohistochemistry results strengthened these findings. Conclusion These findings suggest that argon-mediated anti-apoptotic and neuroprotective effects are mediated via inhibition of TLR2 and TLR4.

Published
2015

71. Risk factors for post-operative pulmonary complications in lung cancer patients after video-assisted thoracoscopic lung resection: Results of the German Thorax Registry.

Author

Kaufmann, Kai B., Loop, Torsten, Heinrich, Sebastian, and Working Group of the German Thorax Registry

Subjects
*LOBECTOMY (Lung surgery), *LUNG cancer, *CANCER patients, *DISEASE risk factors, *LOGISTIC regression analysis, *LUNG surgery, *THORACIC surgery, *COMPARATIVE studies, *LUNG diseases, *LUNG tumors, *RESEARCH methodology, *MEDICAL cooperation, *PNEUMONECTOMY, *RESEARCH, *SURGICAL complications, *EVALUATION research, *ACQUISITION of data, *RETROSPECTIVE studies, *FORCED expiratory volume
Abstract

Objective: Post-operative pulmonary complications (PPCs) represent the most frequent complications after lung surgery. The aim of this study was to identify the modifiable risk factors for PPCs after video-assisted thoracoscopic surgery (VATS) in lung cancer patients.Methods: Data of this retrospective study were extracted from the German Thorax Registry, an interdisciplinary and multicenter database of the German Society of Anesthesiology and Intensive care medicine and the German Society of Thoracic Surgery. Univariate and multivariate stepwise logistic regression analysis of patient-specific and procedural risk factors for PPCs were conducted.Results: We analyzed 376 patients with lung cancer who underwent VATS bilobectomy (n = 2), lobectomy (n = 258) or segmentectomy (n = 116) in 2016 and 2017. One-hundred fourteen patients (114/376; 30%) developed PPCs. Two patients died within 30 days after surgery. In the univariate analysis, patients of the PPC group showed significantly more often a body mass index (BMI) ≤ 19 kg/m2 ; a pre-operative forced expiratory volume in 1 second (FEV1 ) ≤ 60%; a pre-operative arterial oxygen partial pressure (pa O2 ) ≤ 60 mm Hg; a higher rate of prolonged duration of surgery (≥2 hours [h]) and a higher frequency of intraoperative blood loss ≥500 mL. The multivariate stepwise logistic regression analysis revealed 4 independent risk factors: FEV1 ≤ 60% (1.9[1.1-3.4] OR [95% CI], P = 0.029); pa O2 ≤ 60 mm Hg (4.6[1.7-12.8] OR [95% CI], P = 0.003; duration of surgery ≥2 hours (2.7[1.5-4.7] OR [95% CI], P = 0.001) and intraoperative crystalloids ≥6 mL/kg/h (2.9[1.2-7.5] OR [95% CI], P = 0.023).Conclusion: Intraoperative amount of crystalloid fluids should be kept below 6 mL/kg/h and duration of surgery should be below 2 hours to avoid an increased risk for PPCs. [ABSTRACT FROM AUTHOR]

Published
2019
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72. Hemorrhagic shock primes the hepatic portal circulation for the vasoconstrictive effects of endothelin-1

Author

PANNEN, BENEDIKT H. J., SCHROLL, STEPHAN, LOOP, TORSTEN, BAUER, MICHAEL, HOETZEL, ALEXANDER, and GEIGER, KLAUS K.

Subjects
Vasoconstrictors -- Physiological aspects, Cardiovascular receptors -- Physiological aspects, Microcirculation -- Physiological aspects, Hemorrhagic shock -- Physiological aspects, Biological sciences
Abstract

To test whether hemorrhagic shock and resuscitation (HSR) alters the vascular responsiveness of the portohepatic circulation to endothelins (ETs), we studied the macro- and microcirculatory effects of the preferential [ET.sub.A] receptor agonist ET-1 and of the selective [ET.sub.B] receptor agonist sarafotoxin 6c (S6c) after 1 h of hemorrhagic hypotension and 5 h of volume resuscitation in the isolated perfused rat liver ex vivo using portal pressure-flow relationships and epifluorescence microscopy. Although HSR did not cause major disturbances of hepatic perfusion per se, the response to ET-1 (0.5 x [10.sup.-9] M) was enhanced, leading to greater increases in portal driving pressure, total portal resistance, and zero-flow pressures and more pronounced decreases in portal flow, sinusoidal diameters, and hepatic oxygen delivery compared with time-matched sham shock controls. In sharp contrast, the constrictive response to S6c (0.25 x [10.sup.-9] M) remained unchanged. Thus HSR primes the portohepatic circulation for the vasoconstrictive effects of ET-1 but does not alter the effects of the [ET.sub.B] receptor agonist S6c. The enhanced sinusoidal response may contribute to the subsequent development of hepatic microcirculatory failure after secondary insults that are associated with increased generation of ET-1. endothelin receptors; microcirculation; portal vein; pressure-flow relationship; sarafotoxin 6c

Published
2001

74. Argon inhalation attenuates retinal apoptosis after ischemia/reperfusion injury in a time- and dose-dependent manner in rats

Author

Ulbrich, Felix, Schallner, Nils, Coburn, Mark, Loop, Torsten, Lagrèze, Wolf Alexander, Biermann, Julia, and Goebel, Ulrich

Subjects
Male, Critical Care and Emergency Medicine, genetic structures, Immunology, General Anesthesia, lcsh:Medicine, Apoptosis, Pathology and Laboratory Medicine, Retina, Rats, Sprague-Dawley, Signs and Symptoms, Anesthesiology, Administration, Inhalation, Medicine and Health Sciences, Animals, Anesthesia, RNA, Messenger, Argon, lcsh:Science, Immune Response, General Inhalational Anesthesia, Trauma Medicine, bcl-2-Associated X Protein, Inflammation, Cerebral Ischemia, Cell Death, Caspase 3, lcsh:R, Biology and Life Sciences, Cell Biology, eye diseases, Rats, Gene Expression Regulation, Neoplastic, Chemistry, Proto-Oncogene Proteins c-bcl-2, Neurology, Cell Processes, Reperfusion Injury, Physical Sciences, lcsh:Q, Female, sense organs, Research Article, Chemical Elements
Abstract

PLoS one 9(12), e115984 (2014). doi:10.1371/journal.pone.0115984, Published by PLoS, Lawrence, Kan.

Published
2014
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76. Carbon monoxide abrogates ischemic insult to neuronal cells via the soluble guanylate cyclase-cGMP pathway

Author

Schallner, Nils, Romão, Carlos C., Biermann, Julia, Lagrèze, Wolf A., Otterbein, Leo E., Buerkle, Hartmut, Loop, Torsten, and Goebel, Ulrich

Subjects
Male, Retinal Ganglion Cells, Receptors, Cytoplasmic and Nuclear, lcsh:Medicine, Apoptosis, Signal transduction, Brain Ischemia, Rats, Sprague-Dawley, Molecular cell biology, Soluble Guanylyl Cyclase, Coordination Complexes, lcsh:Science, Cyclic GMP, Cellular Stress Responses, Neurons, Carbon Monoxide, Cell Death, Neurochemistry, Animal Models, Flow Cytometry, Neuroprotective Agents, Neurology, Reperfusion Injury, Medicine, Retinal Disorders, Female, Neurochemicals, Research Article, Drugs and Devices, Cerebrovascular Diseases, Signaling in cellular processes, Nitric Oxide, Signaling Pathways, Gene Expression Regulation, Enzymologic, Model Organisms, Neuropharmacology, Cell Line, Tumor, Rotenone, Organometallic Compounds, Animals, Humans, Biology, Ischemic Stroke, Molybdenum, Dose-Response Relationship, Drug, lcsh:R, NADPH Oxidases, Rats, Ophthalmology, Guanylate Cyclase, cGMP signaling, Neuro-Ophthalmology, Rat, lcsh:Q, Antiapoptotic signaling, Molecular Neuroscience, Reactive Oxygen Species, Cytometry, Neuroscience
Abstract

Purpose Carbon monoxide (CO) is an accepted cytoprotective molecule. The extent and mechanisms of protection in neuronal systems have not been well studied. We hypothesized that delivery of CO via a novel releasing molecule (CORM) would impart neuroprotection in vivo against ischemia-reperfusion injury (IRI)-induced apoptosis of retinal ganglion cells (RGC) and in vitro of neuronal SH-SY5Y-cells via activation of soluble guanylate-cyclase (sGC). Methods To mimic ischemic respiratory arrest, SH-SY5Y-cells were incubated with rotenone (100 nmol/L, 4 h) ± CORM ALF186 (10–100 µmol/L) or inactivated ALF186 lacking the potential of releasing CO. Apoptosis and reactive oxygen species (ROS) production were analyzed using flow-cytometry (Annexin V, mitochondrial membrane potential, CM-H2DCFDA) and Western blot (Caspase-3). The impact of ALF186± respiratory arrest on cell signaling was assessed by measuring expression of nitric oxide synthase (NOS) and soluble guanylate-cyclase (sGC) and by analyzing cellular cGMP levels. The effect of ALF186 (10 mg/kg iv) on retinal IRI in Sprague-Dawley rats was assessed by measuring densities of fluorogold-labeled RGC after IRI and by analysis of apoptosis-related genes in retinal tissue. Results ALF186 but not inactivated ALF186 inhibited rotenone-induced apoptosis (Annexin V positive cells: 25±2% rotenone vs. 14±1% ALF186+rotenone, p

Published
2013

80. Argon mediates protection by interleukin-8 suppression via a TLR2/TLR4/STAT3/NF-κB pathway in a model of apoptosis in neuroblastoma cells in vitro and following ischemia-reperfusion injury in rat retina in vivo.

Author

Ulbrich, Felix, Lerach, Teresa, Biermann, Julia, Kaufmann, Kai B., Lagreze, Wolf A., Buerkle, Hartmut, Loop, Torsten, and Goebel, Ulrich

Subjects
INTERLEUKIN-8, APOPTOSIS, NEUROBLASTOMA, ISCHEMIA, MITOCHONDRIAL membranes
Abstract

Argon has recently come into scientific focus as a neuroprotective agent. The underlying neuroprotective mechanism remains unknown although toll-like receptors were recently suggested to play an important role. We hypothesized that TLR-associated downstream transcription factors are responsible for argon's effects, leading to anti-apoptotic and anti-inflammatory properties. Apoptosis was induced in human neuroblastoma cells. Immediately afterwards, argon treatment (75 Vol% for 2 h) was initiated. Cells were analyzed, measuring mitochondrial membrane potential, reactive-oxygen-species, annexin-V/propidium iodide staining, transcription factor phosphorylation and binding activity as well as protein and mRNA expression of interleukins. Argon's in vivo effects were analyzed by quantification of retinal ganglion cell density, mRNA expression, serum cytokine analysis and immunohistochemistry after retinal ischemia reperfusion injury (IRI) in rats. Argon diminished rotenone-induced kappa-light-chain-enhancer' of activated B-cells (NF-κB) and signal transducer and activator of transcription 3 (STAT3) but not STAT5 or cAMP-response element-binding protein (CREB) phosphorylation and DNA-binding activity. Argon treatment attenuated apoptosis by preservation of mitochondrial membrane potential and decline in reactive oxygen species (ROS) generation. NF-κB and STAT3 inhibition, as well as TLR2 and TLR4 inhibition reversed argon's effects on IL-8 mRNA expression. Argon attenuated rotenone-induced IL-8 protein and mRNA expression in vitro. Inhibition of TLR2 and 4 attenuated argon's protective effect in vivo reducing IRI driven retinal IL-8 expression. IL-8 expression was found in the retina in co-localization with Müller cells and retinal ganglion cells. Argon mediates its neuroprotective effects by TLR-mediated regulation of transcription factors NF-κB and STAT3, thus decreasing interleukin-8 expression in vitro and in vivo. These findings may open up new opportunities to effectively treat cerebral ischemia and reperfusion injury through the inhalation of argon. [ABSTRACT FROM AUTHOR]

Published
2016
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90. Carbon Monoxide Inhalation Reduces Pulmonary Inflammatory Response during Cardiopulmonary Bypass in Pigs

Author

Goebel, Ulrich, primary, Siepe, Matthias, additional, Mecklenburg, Anne, additional, Stein, Phillip, additional, Roesslein, Martin, additional, Schwer, Christian I., additional, Schmidt, Rene, additional, Doenst, Torsten, additional, Geiger, Klaus K., additional, Pahl, Heike L., additional, Schlensak, Christian, additional, and Loop, Torsten, additional

Published
2008
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92. Thionamides Inhibit the Transcription Factor Nuclear Factor-κB by Suppression of Rac1 and Inhibitor of κB Kinase α

Author

Humar, Matjaz, primary, Dohrmann, Hannah, additional, Stein, Philipp, additional, Andriopoulos, Nikolaos, additional, Goebel, Ulrich, additional, Roesslein, Martin, additional, Schmidt, Rene, additional, Schwer, Christian I., additional, Loop, Torsten, additional, Geiger, Klaus K., additional, Pahl, Heike L., additional, and Pannen, Benedikt H.J., additional

Published
2007
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93. Repression of T-Cell Function by Thionamides Is Mediated by Inhibition of the Activator Protein-1/Nuclear Factor of Activated T-Cells Pathway and Is Associated with a Common Structure

Author

Humar, Matjaz, primary, Dohrmann, Hannah, additional, Stein, Philipp, additional, Andriopoulos, Nikolaos, additional, Goebel, Ulrich, additional, Heimrich, Bernd, additional, Roesslein, Martin, additional, Schmidt, Rene, additional, Schwer, Christian I., additional, Hoetzel, Alexander, additional, Loop, Torsten, additional, Pahl, Heike L., additional, Geiger, Klaus K., additional, and Pannen, Benedikt H. J., additional

Published
2007
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97. Volatile Anesthetics Induce Caspase-dependent, Mitochondria-mediated Apoptosis in Human T Lymphocytes In Vitro

Author

Loop, Torsten, primary, Dovi-Akue, David, additional, Frick, Michael, additional, Roesslein, Martin, additional, Egger, Lotti, additional, Humar, Matjaz, additional, Hoetzel, Alexander, additional, Schmidt, Rene, additional, Borner, Christoph, additional, Pahl, Heike L., additional, Geiger, Klaus K., additional, and Pannen, Benedikt H. J., additional

Published
2005
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99. Sevoflurane Inhibits Phorbol-Myristate-Acetate-induced Activator Protein-1 Activation in Human T Lymphocytes in Vitro : Potential Role of the p38-Stress Kinase Pathway

Author

Loop, Torsten, primary, Scheiermann, Patrick, additional, Doviakue, David, additional, Musshoff, Frank, additional, Humar, Matjaz, additional, Roesslein, Martin, additional, Hoetzel, Alexander, additional, Schmidt, Rene, additional, Madea, Burkhard, additional, Geiger, Klaus K., additional, Pahl, Heike L., additional, and Pannen, Benedikt H. J., additional

Published
2004
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100. Inhibition of Activator Protein 1 by Barbiturates Is Mediated by Differential Effects on Mitogen-Activated Protein Kinases and the Small G Proteins Ras and Rac-1

Author

Humar, Matjaz, primary, Andriopoulos, Nikolaos, additional, Pischke, Soeren E., additional, Loop, Torsten, additional, Schmidt, Rene, additional, Hoetzel, Alexander, additional, Roesslein, Martin, additional, Pahl, Heike L., additional, Geiger, Klaus K., additional, and Pannen, Benedikt H. J., additional

Published
2004
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