51. Anterior cingulate activity in bulimia nervosa: a fMRI case study.
- Author
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Peñas-Lledó EM, Loeb KL, Martin L, and Fan J
- Subjects
- Adolescent, Adult, Arousal physiology, Attention physiology, Brain Mapping, Bulimia Nervosa diagnosis, Bulimia Nervosa psychology, Cognition Disorders diagnosis, Cognition Disorders physiopathology, Cognition Disorders psychology, Female, Humans, Neuropsychological Tests, Problem Solving physiology, Psychomotor Performance physiology, Reaction Time physiology, Bulimia Nervosa physiopathology, Gyrus Cinguli physiopathology, Image Processing, Computer-Assisted, Magnetic Resonance Imaging
- Abstract
Introduction: Eating disordered patients (EDp) who binge-eat appear to present impulse control deficits that influence treatment outcome. The present bulimia nervosa (BN) study tests the function of brain areas involved in top-down control of behavior, associated with the anterior cingulate cortex (ACC), at the individual level., Methods: ACC activity was analyzed in two women with BN and one matched control with a reliable and simple cue imperative target paradigm for response anticipation and response conflict processing using an event-related functional magnetic resonance imaging (fMRI) design., Results: Patients showed meaningful ACC patterns of activation, less recruitment for response anticipation, and abnormal for response conflict, when they had to suppress an inappropriate response., Discussion: Preliminary evidence suggests a BN neurocognitive model of impaired executive control-related brain activity. Reliable fMRI paradigms may be clinically useful to determine ACC dysfunction in EDp, to inform treatment and track changes.
- Published
- 2007
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