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376 results on '"Liu, Zhiqian"'

57. circFAM134Bis a key factor regulating reticulophagy-mediated ferroptosis in hepatocellular carcinoma

Author

Bi, Tao, Lu, Qianqian, Pan, Xiaohong, Dong, Fenglin, Hu, Yejia, Xu, Zongzhen, Xiu, Peng, Liu, Zhiqian, and Li, Jie

Abstract

ABSTRACTFerroptosis is an important mode of regulated cell death (RCD). Its inhibition is closely related to therapeutic resistance and poor prognosis in hepatocellular carcinoma (HCC). Previous reports have demonstrated ferroptosis as a biological process highly dependent on selective autophagy, such as ferritinophagy, lipophagy, and clockophagy. Our study also revealed a role for ER-phagy-mediated ferroptosis in HCC cells treated with multi-targeted tyrosine kinase inhibitors (TKIs). In the current study, we found that the homologous circular RNA (circRNA) of the family with sequence similarity 134, member B (FAM134B), hsa_circ_0128505 (was abbreviated as circFAM134Bin the present study), was identified to specifically target ER-phagy to promote lenvatinib (LV)-induced ferroptosis using reactive oxygen species (ROS), Fe2+, malondialdehyde (MDA), and western blot (WB) assays in HCC cells. RNA pull-down and mass spectrometry analyses suggested that circFAM134Band FAM134BmRNA were enriched with several common interacting proteins. Among them, poly (A) binding protein cytoplasmic 4 (PABPC4) was identified as the most enriched binding partner. It was proven to be a novel antagonist against the nonsense-mediated mRNA decay (NMD) mechanism. We then applied RNA immunoprecipitation (RIP), RNA pull-down, luciferase reporter, and NMD reporter gene assays to further explore the exact role and underlying mechanism of circFAM134B-PABPC4-FAM134B axis in HCC cells. circFAM134Bwas confirmed as a sponge that competitively interacted with PABPC4, thereby influencing FAM134BmRNA nonsense decay. Our results provide novel evidences and strategies for the comprehensive treatment of HCC.

Published
2023
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68. L-Cys-Assisted Conversion of H2/CO2 to Biochemicals Using Clostridium ljungdahlii.

Author

Yang, Yuling, Cao, Weifeng, Shen, Fei, Liu, Zhiqian, Qin, Linli, Liang, Xinquan, and Wan, Yinhua

Abstract

Carbon fixation and conversion based on Clostridium ljungdahlii have great potential for the sustainable production of biochemicals (i.e., 2,3-butanediol, acetic acid, and ethanol). Here, the effects of reducing agents on the production of biochemicals from H2/CO2 using C. ljungdahlii were studied. It was found that the element S and reducing power could significantly affect the production of biochemicals, and cysteine (Cys) was better than sodium sulfide for the production of biochemicals, especially for the production of 2,3-butanediol. Moreover, comparing to the control (i.e., without the addition of Cys), the gene expression profiles indicated that the fdh and adhE1 were significantly upregulated with the addition of Cys, which involved in pathways of the CO2 fixation and ethanol production. Therefore, the irreplaceability of Cys on the production of biochemicals was both caused by its utilization as a reducing agent and its effect on the metabolic pathway. Finally, compared to the control, the production of 2,3-butanediol was increased by 2.17 times under the addition of 1.7 g/L Cys. [ABSTRACT FROM AUTHOR]

Published
2023
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69. Comparison of Workflows for Milk Lipid Analysis: Phospholipids.

Author

Li, Cheng, Liu, Zhiqian, Marett, Leah, Pryce, Jennie, and Rochfort, Simone

Subjects
LIPID analysis, PHOSPHOLIPIDS, PHOSPHATIDYLSERINES, GRADIENT elution (Chromatography), MILK, LIPIDS, MILKFAT, LIQUID chromatography-mass spectrometry
Abstract

Milk is a rich source of lipids, with the major components being triglycerides (TAG) and phospholipids (mainly phosphatidylcholine (PC), sphingomyelin (SM), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI)). Liquid chromatography-mass spectrometry (LC-MS) is the predominant technique for lipid identification and quantification across all biological samples. While fatty acid (FA) composition of the major lipid classes of milk can be readily determined using tandem MS, elucidating the regio-distribution and double bond position of the FA remains difficult. Various workflows have been reported on the quantification of lipid species in biological samples in the past 20 years, but no standard or consensus methods are currently available for the quantification of milk phospholipids. This study will examine the influence of several common factors in lipid analysis workflow (including lipid extraction protocols, LC stationary phases, mobile phase buffers, gradient elution programmes, mass analyser resolution and isotope correction) on the quantification outcome of bovine milk phospholipids. The pros and cons of the current LC-MS methods as well as the critical problems to be solved will also be discussed. [ABSTRACT FROM AUTHOR]

Published
2023
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70. The co-evolution propagation model of information and epidemic based on information maximizing influence

Author

Yaqiong Wang, Guanghui Yuan, and Liu Zhiqian

Subjects
Social network, Warning system, Transmission (telecommunications), Risk analysis (engineering), business.industry, Order (exchange), Computer science, Control (management), Information processing, Information quality, Maximization, business
Abstract

In this paper, from the perspective of improving the effect of scientific early warning information, the co-evolution propagation model of information and epidemic is studied. In order to improve the quality of information in the network, the co-evolution propagation model of information and epidemic is controlled based on the research on the co-evolution propagation model of information and epidemic from the perspective of improving the effect of positive information. It improves the quality of information in the network information layer by using the influential individuals in the social network. This paper will build a co-evolution propagation model of information and epidemic based on the maximization of influence. It combines the calculation method of individual influence in order to use the influential individuals in social networks to improve the transmission efficiency of epidemic warning information. And it tries to improve the quality of information and the effect of early warning with less control and less cost. Through theoretical analysis and numerical simulation analysis, it is found that the influence of information on individual behavior plays a greater role in the co-evolution propagation model of information and epidemic. At the same time, by increasing the information transmission rate and influential individuals in the network information layer, the number of infectious epidemic will be reduced. To a certain extent, it shows that information early warning plus influence control is effective.

Published
2021

73. Parameter Analysis and Optimization of Friction Pendulum Bearings in Underground Stations Based on Genetic Algorithm.

Author

Chen, Zhiyi, Jia, Peng, Fan, Yifan, and Liu, Zhiqian

Subjects
FRICTION, PENDULUMS, EARTHQUAKE magnitude, FINITE element method, GENETIC algorithms, RADIUS (Geometry)
Abstract

This paper analyses the influence of friction coefficient and equivalent radius on the seismic reduction effect of friction pendulum bearings in the underground station under far-field and near-field earthquakes with different strength. It is found that the parameters of the friction pendulum bearings will obviously influence seismic reduction effectiveness. By combining genetic algorithm with finite element method, the parameters of friction pendulum bearings in the station can be optimized. By using this method, the optimal parameters range can be obtained, which can provide reference for parameter design of friction pendulum bearings in underground stations. [ABSTRACT FROM AUTHOR]

Published
2022
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77. Mapping PrBn and other quantitative trait loci responsible for the control of homeologous chromosome pairing in oilseed rape (Brassica napus L.) haploids

Author

Liu, Zhiqian, Adamczyk, Katarzyna, Manzanares-Dauleux, Maria, Eber, Frederique, Lucas, Marie-Odile, Delourme, Regine, Chevre, Anne Marie, and Jenczewski, Eric

Subjects
Chromosomes -- Research, Genetic variation -- Analysis, Rape (Plant) -- Genetic aspects, Biological sciences
Abstract

In allopolyploid species, fair meiosis could be challenged by homeologous chromosome pairing and is usually achieved by the action of homeologous pairing suppressor genes. Oilseed rape (Brassica napus) haploids (AC, n = 19) represent an attractive model for studying the mechanisms used by allopolyploids to ensure the diploid-like meiotic pairing pattern. In oilseed rape haploids, homeologous chromosome pairing at metaphase I was found to be genetically based and controlled by a major gene, PrBn, segregating in a background of polygenic variation. In this study, we have mapped PrBn within a 10-cM interval on the C genome linkage group DY15 and shown that PrBn displays incomplete penetrance or variable expressivity. We have identified three to six minor QTL/BTL that have slight additive effects on the amount of pairing at metaphase I but do not interact with PrBn. We have also detected a number of other loci that interact epistatically, notably with PrBn. Our results support the idea that, as in other polyploid species, metaphase I homeologous pairing in oilseed rape haploids is controlled by an integrated system of several genes, which function in a complex manner.

Published
2006

85. Marine Protists and Rhodotorula Yeast as Bio-Convertors of Marine Waste into Nutrient-Rich Deposits for Mangrove Ecosystems

Author

Miranda, Ana F., primary, Nham Tran, Thi Linh, additional, Abramov, Tomer, additional, Jehalee, Faridah, additional, Miglani, Mohini, additional, Liu, Zhiqian, additional, Rochfort, Simone, additional, Gupta, Adarsha, additional, Cheirsilp, Benjamas, additional, Adhikari, Benu, additional, Puri, Munish, additional, and Mouradov, Aidyn, additional

Published
2020
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89. BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice

Author

Seth Chhabra, Ekta, primary, Liu, Tongyao, primary, Kulman, John, primary, Patarroyo-White, Susannah, primary, Yang, Buyue, primary, Lu, Qi, primary, Drager, Douglas, primary, Moore, Nancy, primary, Liu, Jiayun, primary, Holthaus, Amy M., primary, Sommer, Jurg M., primary, Ismail, Ayman, primary, Rabinovich, Deana, primary, Liu, Zhan, primary, van der Flier, Arjan, primary, Goodman, Allison, primary, Furcht, Chris, primary, Tie, Mark, primary, Carlage, Tyler, primary, Mauldin, Randy, primary, Dobrowsky, Terrence M., primary, Liu, Zhiqian, primary, Mercury, Oblaise, primary, Zhu, Lily, primary, Mei, Baisong, primary, Schellenberger, Volker, primary, Jiang, Haiyan, primary, Pierce, Glenn F., primary, Salas, Joe, primary, and Peters, Robert, primary

Published
2020
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93. Naturally Occurring Bioactive Oligosaccharides in Goat's Milk-Infant Formula (P11-078-19)

Author

Christopher J. Pillidge, Simone Rochfort, Bogdan Zisu, Andrea Leong, Harsharn Gill, and Liu Zhiqian

Subjects
Goat's milk, Maternal, Perinatal and Pediatric Nutrition, Nutrition and Dietetics, Molecular mass, Microorganism, Medicine (miscellaneous), Biology, biology.organism_classification, Microbiology, Cytolysis, Infant formula, Lactobacillus, Breast feeding, Food Science, Bifidobacterium
Abstract

OBJECTIVES: Human milk is rich in oligosaccharides (OS) that impart significant health benefits to the infant. When breast feeding is not possible, infant formula (IF) is used as an alternative. However, little is known about the presence of OS in IF and their potential health effects. This study was aimed at quantifying naturally occurring OS in a commercial goat's milk IF and examining their prebiotic and anti-infection properties. METHODS: OS were isolated from IF using molecular weight cut-off filters and HILIC-LC/MS system. Prebiotic activity of OS was assessed by co-incubating Bifidobacterium (BB12 and BB526) and Lactobacillus (LA4461 and LC2607) strains in growth media with or without OS anaerobically at 37°C for 24 hr and measuring OD(600). Anti-adhesion potential of OS was determined by co-incubating E. coli NCTC 10418 and S. typhimurium, pre-incubated with or without OS for 2 hr at 37°C, with Caco-2 cells for 90 min. After PBS washes and cell lysis, supernatants were plated onto agars for measuring bacterial counts and calculating the anti-adhesion %. RESULTS: Fourteen OS were quantified in goat's milk IF, of which 5 were structurally similar to those reported in human milk. At concentrations similar to those in reconstituted IF, OS fractions were significantly effective in enhancing the growth of bifidobacteria and lactobacilli strains and preventing the adhesion of E. coli NCTC10418 (52.4%) and S. typhimurium (35%) to the Caco-2 cells. CONCLUSIONS: Goat's milk IF contains several naturally occurring human milk-like OS that appear to promote the growth of beneficial gut microbes and protect against gut pathogens. FUNDING SOURCES: No conflicts of interest were involved. Nuchev Pty Ltd. provided goat's milk IF. Research costs were covered by RMIT University.

Published
2019

96. Vehicle Air Conditioner Temperature Regulation-based Orderly Charging Strategy for Electric Vehicles

Author

Long Hongyu, Wei Song, Liu Zhiqian, Chenxu Zhao, and Piao Changhao

Subjects
Air conditioning, business.industry, Environmental science, business, Automotive engineering
Abstract

Due to high power load peaks and long durations in extreme weather conditions, as well as large-scale unscheduled electric vehicles charging, it may cause “peak plus peak” loading in local areas of the power grid, moreover, lead to transformer substations overload operation in local areas, which is not good for distribution safe and stable operation of the power grid. Considering the driver’s willingness, this study proposes an orderly charging strategy based on the temperature control of electric vehicle on-board air conditioner. The proposed strategy first constructs the temperature control model for electric vehicle cabins with considering the temperature of entire electric vehicle and the special characteristics of urban roads. Then, multi-objective function is formed with minimum user charging cost and variance of grid load fluctuations. Finally, electric vehicles orderly charging period is optimized by combining with electric vehicle travel chains, charge constraints, time-of-use electricity prices, and substation capacity constraints. The results show that temperature-controlled dispatching can effectively reduce the electric vehicles disorderly charging load. It can serve the power grid “cut peaks and fill valleys” and smooth the overall grid load curve using an improved Lagrange relaxation algorithm to optimize electric vehicles charging period.

Published
2020

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