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342 results on '"Liu, Xiaozheng"'

52. Alterations in Spontaneous Neuronal Activity and Microvascular Density of the Optic Nerve Head in Active Thyroid-Associated Ophthalmopathy

Author

Zhu, Pingyi, primary, Liu, Zihui, additional, Lu, Yi, additional, Wang, Yu, additional, Zhang, Danbin, additional, Zhao, Pinghui, additional, Lin, Lulu, additional, Hussein, Nimo Mohamed, additional, Liu, Xiaozheng, additional, Yan, Zhihan, additional, Bai, Guanghui, additional, and Tu, Yunhai, additional

Published
2022
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54. Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary Insomnia

Author

Ji,Bin, Dai,Min, Guo,Zhongwei, Li,Jiapeng, Cao,Yulin, Zhang,Zhenzhong, Zhang,Yan, Liu,Xiaozheng, Ji,Bin, Dai,Min, Guo,Zhongwei, Li,Jiapeng, Cao,Yulin, Zhang,Zhenzhong, Zhang,Yan, and Liu,Xiaozheng

Abstract

Bin Ji,1 Min Dai,2 Zhongwei Guo,3 Jiapeng Li,4 Yulin Cao,4 Zhenzhong Zhang,3 Yan Zhang,3 Xiaozheng Liu2 1Department of Anesthesiologyand Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People’s Republic of China; 2Department of Radiology of the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People’s Republic of China; 3The Sleep Medical Center of Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, People’s Republic of China; 4Department of Radiology of Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, People’s Republic of ChinaCorrespondence: Yan ZhangThe Sleep Medical Center of Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou, Zhejiang, 310012, People’s Republic of ChinaEmail zhyan73@163.comXiaozheng LiuDepartment of Radiology of the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, No. 109 Xueyuan West Road, Wenzhou, Zhejiang, 325027, People’s Republic of ChinaEmail lxz_2088@hotmail.comObjective: It is unclear whether the patterns of functional connectivity density (FCD) differ between patients with primary insomnia (PI) and healthy subjects. In the present study, we investigated the features of FCD in patients with PI using resting-state functional MRI (rsfMRI).Methods: rsfMRI datasets of 32 patients with PI and 34 healthy controls (HCs) were obtained using a 3-Tesla scanner. FCD analysis was performed to compare voxels with abnormal whole-brain functional connectivity with other voxels among patients with PI and HCs. Abnormal brain regions were then used as seed points for FC analysis.Results: Compared with HCs, patients with PI exhibited significantly decreased FCD in the left medial frontal gyrus and increased FCD in the left supplementary motor area (SMA). With the left medial frontal gyrus as the

Published
2022

67. Mechanistic Insight and Translational Possibilities of Obesity-Breast Cancer Connection

Author

Liu, Xiaozheng

Abstract

Obesity is an independent risk factor for more than thirteen cancer types. In breast cancer context, obesity is strongly associated with higher incidence and poorer prognosis in postmenopausal patients. The management of breast cancer in obese patients is faced with numerous challenges, as dosing, toxicity and drug efficacy. Thus, it is highly demanded to investigate the in-depth mechanisms underlying the obesity-cancer connection and translate these fundamental mechanisms into clinical applications. To this end, we first searched for breast cancer phenotypes driven by the obese environment. In both patients and preclinical models, we identified enhanced stem-like traits in cancer cells exposed to the obese settings and it independently predicted breast cancer risks. Next, as obesity-induced elevated free fatty acid is a central phenotype in obese individuals, we established in vitro cancer cell models by long-term exposure to palmitic acid. Under this condition, cancer cells consistently dedifferentiated towards a cancer stem-like phenotype and displayed enhanced tumor initiation capacity. Mechanistically, we found that the obesity-induced phenotype was governed epigenetically through remodeling the chromatin landscape in cancer cells, specifically through increased chromatin occupancy of the transcription factor CCAAT/enhancer-binding protein beta (C/EBPB). We further identified Lipocalin 2 and Claudin 1 as the key downstream target genes of C/EBPB and functionally demonstrated the critical roles of C/EBPB and its targets in obesity-induced breast cancer initiation phenotypes. The second part of this thesis focuses on the investigation of endotrophin-induced physiological responses in human cells and the clinical translational potential. The cleavage product of collagen VI alpha 3 chain, endotrophin, is upregulated in obese states and has been previously reported as a stimulator for oncogenic transformation of mammary ductal epithelial cells in rodents. In addition, endotrophin presents pro-fibrotic, chemoattractant, pro-angiogenic and epithelial to mesenchymal transition induction properties in murine cells. Here, we demonstrated that the circulating levels of endotrophin is increased in breast cancer patients compared with healthy individuals. Recombinant human endotrophin exerted similar effects on human cell lines as in murine cells, suggesting that endotrophin is a viable target for breast cancer therapy. As such, we developed neutralizing antibodies targeting human endotrophin, and ultimately validated the effectiveness of such antibody in human breast cancer cell lines and human cell line-derived nude mouse models. In both in vitro and in vivo models, the antibody showed potent tumor growth inhibition and anti-cisplatin resistance functions, and thus provided the important stage towards developing targeted therapies for obese breast cancer patients. Doktorgradsavhandling

Published
2021

78. Disrupted balance of long and short-range functional connectivity density in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) patients: a resting-state fMRI study

Author

Mao, Yanping, primary, Liao, Zhengluan, additional, Liu, Xiaozheng, additional, Li, Ting, additional, Hu, Jiaojiao, additional, Le, Dansheng, additional, Pei, Yangliu, additional, Sun, Wangdi, additional, Lin, Jixin, additional, Qiu, Yaju, additional, Zhu, Junpeng, additional, Chen, Yan, additional, Qi, Chang, additional, Su, Heng, additional, and Yu, Enyan, additional

Published
2021
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81. The Evaluation of Longitudinal Strain of Large and Small Abdominal Aortic Aneurysm by Two‐Dimensional Speckle‐Tracking Ultrasound.

Author

Ning, Hongxia, Liu, Xiaozheng, Ma, Chunyan, Yang, Jun, and Li, Tan

Subjects
ABDOMINAL aortic aneurysms, RECEIVER operating characteristic curves, VASCULAR diseases, ULTRASONIC imaging, THROMBOSIS, CEREBRAL angiography, FETAL ultrasonic imaging
Abstract

Objectives: Abdominal aortic aneurysm (AAA) is a dangerous and lethal vascular disease. Non‐invasive two‐dimensional speckle‐tracking imaging (2D STI) plays an important role in assessing aortic biomechanical properties. Our study aimed to evaluate the alterations of biomechanical characteristics using 2D STI in 91 AAA patients with different size. Methods: Aneurysm strain, elastic modulus, stiffness index β, and aortic distensibility determined by M‐Mode ultrasound (US), and longitudinal strain (LS) derived from 2D STI were compared in 40 large AAA patients (diameter ≥ 55 mm) and 51 small AAA patients (diameter < 55 mm). Results: Compared with small AAA group, anterior wall longitudinal strain (ALS) and posterior wall longitudinal strain (PLS) were significantly decreased in large AAA group (all P <.05) and not affected by age, symptom, hypertension, and thrombus. Meanwhile, ALS and PLS correlated negatively with maximal aneurysm diameters (r = −0.628 and −0.469, respectively, all P <.001). And only ALS was associated with M‐Mode US parameters (all P <.05). Based on receiver operating characteristic (ROC) analysis, ALS and PLS had strong diagnostic values for large AAA with the area under the curve (AUC) of 0.82 and 0.72, and cut‐off points of 1.71 and 1.64% with a sensitivity of 78 and 72%, and a specificity of 75 and 70%, respectively. Conclusions: LS measured by 2D STI could evaluate the biomechanical properties of aneurysm wall with different size, and add additional diagnostic value in distinguishing between small and large AAA. [ABSTRACT FROM AUTHOR]

Published
2022
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90. Disrupted Regional Cerebral Blood Flow in Children With Newly-Diagnosed Type 1 Diabetes Mellitus: An Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Study

Author

Song, Jiawen, primary, Cui, Shihan, additional, Chen, Yaomeng, additional, Ye, Xinjian, additional, Huang, Xiaoyan, additional, Su, Haiyan, additional, Zhou, Yongjin, additional, Liu, Xiaozheng, additional, Chen, Wei, additional, Shan, Xiaoou, additional, Yan, Zhihan, additional, and Liu, Kun, additional

Published
2020
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93. Abnormal Functional Connectivity Density in New-Onset Type 1 Diabetes Mellitus Children: A Resting-State Functional Magnetic Resonance Imaging Study

Author

Liu, Kun, primary, Song, Jiawen, additional, Jin, Jiahui, additional, Huang, Xiaoyan, additional, Ye, Xinjian, additional, Cui, Shihan, additional, Zhou, Yongjin, additional, Liu, Xiaozheng, additional, Chen, Wei, additional, Yan, Zhihan, additional, Shan, Xiaoou, additional, and Fu, Yuchuan, additional

Published
2020
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100. Abnormal Functional Connectivity Density in Patients with Dysthyroid Optic Neuropathy.

Author

Tu, Yunhai, Huang, Pingping, Mao, Chuanwan, Liu, Xiaozheng, and Gao, Jianlu

Subjects
FUNCTIONAL connectivity, PREFRONTAL cortex, PARIETAL lobe, TEMPORAL lobe, FUSIFORM gyrus, FRONTAL lobe diseases
Abstract

Objective: Functional connectivity density (FCD) mapping was used to investigate abnormalities and factors related to brain functional connectivity in cortical regions of patients with dysthyroid optic neuropathy (DON) and to analyze the pathogenesis of DON further. Methods: Patients diagnosed with thyroid-associated opthalmology (TAO) in the Eye Hospital were enrolled. All patients underwent comprehensive eye examinations and best-corrected visual acuity, visual field (VF) test. MRI data collection and analysis were completed in the 2nd Affiliated Hospital of Wenzhou Medical University. The patients were divided into 2 groups: the DON group, with an average VF, mean deviation (MD) of both eyes < −5 dB, and the non-DON group (nDON group), with an average VF MD of both eyes ≥ −2 dB. Results: A total of 30 TAO patients (14 men, 16 women) with complete data who met the experimental requirements were enrolled. The average age was 48.79 (40–57) years. There were 16 patients in the DON group and 14 patients in the nDON group. No significant differences in age, gender, education level, and the maximum horizontal diameter of either medial rectus muscle were found between the 2 groups. The difference of brain FCD between the 2 groups showed significant abnormal connectivity in the right orbital gyri of the frontal lobe (Frontal_Inf_Orb_R) and the left precuneus in the DON group compared with the nDON group. As demonstrated by decreased FCD values in the right inferior frontal gyrus/orbital part, the relevant brain regions were the left middle temporal gyrus, left precuneus, left middle frontal gyrus, right postcentral gyrus, and brain gyri (excluding the supramarginal gyrus and angular gyrus) below the left parietal bone. The FCD associated with the left precuneus was increased, and the relevant brain areas were the left middle temporal gyrus, right cuneus, superior occipital gyrus, and right fusiform gyrus. A significant correlation was identified between the MD of the binocular VF and brain FCD. Conclusion: The abnormal FCD in the cortex of DON patients suggests that a central nervous system mechanism may be related to the pathogenesis of the DON. [ABSTRACT FROM AUTHOR]

Published
2022
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