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51. Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice

Author

Verhaegen, Monique E., Harms, Paul W., Van Goor, Julia J., Arche, Jacob, Patrick, Matthew T., Wilbert, Dawn, Zabawa, Haley, Grachtchouk, Marina, Liu, Chia-Jen, Hu, Kevin, Kelly, Michael C., Chen, Ping, Saunders, Thomas L., Weidinger, Stephan, Syu, Li-Jyun, Runge, John S., Gudjonsson, Johann E., Wong, Sunny Y., Brownell, Isaac, Cieslik, Marcin, Udager, Aaron M., Chinnaiyan, Arul M., Tsoi, Lam C., and Dlugosz, Andrzej A.

Subjects
Oncology, Experimental, Merkel cell carcinoma -- Genetic aspects -- Development and progression, Viral antigens -- Genetic aspects, Gene expression -- Research, Cell differentiation -- Research, Tumor antigens -- Genetic aspects, Cancer -- Research, Health care industry
Abstract

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and expresses viral transforming antigens (TAgs). MCC tumor cells also express signature genes detected in skin-resident, postmitotic Merkel cells, including atonal bHLH transcription factor 1 (ATOH1), which is required for Merkel cell development from epidermal progenitors. We now report the use of in vivo cellular reprogramming, using ATOH1, to drive MCC development from murine epidermis. We generated mice that conditionally expressed MCPyV TAgs and ATOH1 in epidermal cells, yielding microscopic collections of proliferating MCC-like cells arising from hair follicles. Immunostaining of these nascent tumors revealed p53 accumulation and apoptosis, and targeted deletion of transformation related protein 53 (Trp53) led to development of gross skin tumors with classic MCC histology and marker expression. Global transcriptome analysis confirmed the close similarity of mouse and human MCCs, and hierarchical clustering showed conserved upregulation of signature genes. Our data establish that expression of MCPyV TAgs in ATOH1-reprogrammed epidermal cells and their neuroendocrine progeny initiates hair follicle-derived MCC tumorigenesis in adult mice. Moreover, progression to full-blown MCC in this model requires loss of p53, mimicking the functional inhibition of p53 reported in human MCPyV-positive MCCs., Introduction Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor with a poor prognosis (1), although up to 50% of patients with advanced disease respond to immunotherapy (2). In [...]

Published
2022
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62. Prognostic role of circulating exosomal miRNAs in multiple myeloma

Author

Manier, Salomon, Liu, Chia-Jen, Avet-Loiseau, Hervé, Park, Jihye, Shi, Jiantao, Campigotto, Federico, Salem, Karma Z., Huynh, Daisy, Glavey, Siobhan V., Rivotto, Bradley, Sacco, Antonio, Roccaro, Aldo M., Bouyssou, Juliette, Minvielle, Stéphane, Moreau, Philippe, Facon, Thierry, Leleu, Xavier, Weller, Edie, Trippa, Lorenzo, and Ghobrial, Irene M.

Published
2017
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63. Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

Author

Mouhieddine, Tarek H., Sperling, Adam S., Redd, Robert, Park, Jihye, Leventhal, Matthew, Gibson, Christopher J., Manier, Salomon, Nassar, Amin H., Capelletti, Marzia, Huynh, Daisy, Bustoros, Mark, Sklavenitis-Pistofidis, Romanos, Tahri, Sabrin, Hornburg, Kalvis, Dumke, Henry, Itani, Muhieddine M., Boehner, Cody J., Liu, Chia-Jen, AlDubayan, Saud H., Reardon, Brendan, Van Allen, Eliezer M., Keats, Jonathan J., Stewart, Chip, Mehr, Shaadi, Auclair, Daniel, Schlossman, Robert L., Munshi, Nikhil C., Anderson, Kenneth C., Steensma, David P., Laubach, Jacob P., Richardson, Paul G., Ritz, Jerome, Ebert, Benjamin L., Soiffer, Robert J., Trippa, Lorenzo, Getz, Gad, Neuberg, Donna S., and Ghobrial, Irene M.

Published
2020
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65. Prompt successful response to a COVID-19 outbreak: Performance of community-based rapid screening station

Author

Liu, Chia-Jen, Yang, Chun-Yi, Chen, Yi-Long, Wang, Samuel Shih-Chih, Chu, Chao-Mei, Hsieh, Ming-Hsuan, Huang, Sheng-Jean, Chang, Yu-Ping, and Hsu, Chia-Chen

Subjects
Policy, Short Communication, Polymerase chain reaction test, COVID-19, Rapid screening station, Humans, Mass Screening, Outbreak, Hot spot, General Medicine, Contact Tracing, Disease Outbreaks
Abstract

An outbreak occurred in Wanhua District of Taipei City. It was traced to a cluster infection originating from a teahouse. To prevent further large-scaled community spread, the Taipei City Government established the first community rapid test screening station. This report describes the station's strategy and performance and key factors that contributed to its operation. The project involves collaboration among various departments of Taipei City Government, including the health, environmental, police, transportation, and fire departments. The station provides rapid screening, polymerase chain reaction (PCR) testing, and immediate isolation and follow-up medical services upon the detection of a positive case. These services are accessible to local residents and are intended to ease hospitals' burdens. In 36 days, a total of 8532 people were tested, and 419 confirmed cases were identified. Over the same period, the weekly number of positive cases in Wanhua District decreased from 356 to 40, and the PCR positive rate decreased from 21.7% to 1.2%. The policy of establishing rapid screening station, contact tracing and mask wearing policy are key strategies for interrupting chains of transmission of COVID-19. This intervention has become a model for preventing the spread of the epidemic and establishing community rapid screening stations in Taiwan.

Published
2022
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68. Supplementary Data from Comprehensive Molecular Profiling of Olfactory Neuroblastoma Identifies Potentially Targetable FGFR3 Amplifications

Author

Lazo de la Vega, Lorena, primary, McHugh, Jonathan B., primary, Cani, Andi K., primary, Kunder, Komal, primary, Walocko, Frances M., primary, Liu, Chia-Jen, primary, Hovelson, Daniel H., primary, Robinson, Dan, primary, Chinnaiyan, Arul M., primary, Tomlins, Scott A., primary, and Harms, Paul W., primary

Published
2023
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69. Supplementary Figures S1-2, Tables S1-3 from Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors

Author

Cani, Andi K., primary, Hovelson, Daniel H., primary, McDaniel, Andrew S., primary, Sadis, Seth, primary, Haller, Michaela J., primary, Yadati, Venkata, primary, Amin, Anmol M., primary, Bratley, Jarred, primary, Bandla, Santhoshi, primary, Williams, Paul D., primary, Rhodes, Kate, primary, Liu, Chia-Jen, primary, Quist, Michael J., primary, Rhodes, Daniel R., primary, Grasso, Catherine S., primary, Kleer, Celina G., primary, and Tomlins, Scott A., primary

Published
2023
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70. Data from Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab

Author

Kurdi, Ahmed T., primary, Glavey, Siobhan V., primary, Bezman, Natalie A., primary, Jhatakia, Amy, primary, Guerriero, Jennifer L., primary, Manier, Salomon, primary, Moschetta, Michele, primary, Mishima, Yuji, primary, Roccaro, Aldo, primary, Detappe, Alexandre, primary, Liu, Chia-Jen, primary, Sacco, Antonio, primary, Huynh, Daisy, primary, Tai, Yu-Tzu, primary, Robbins, Michael D., primary, Azzi, Jamil, primary, and Ghobrial, Irene M., primary

Published
2023
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71. Supplementary Methods, Figure Legends, Figures 1 - 9, Tables 1 - 8 from Multiclonality and Marked Branched Evolution of Low-Grade Endometrioid Endometrial Carcinoma

Author

Lazo de la Vega, Lorena, primary, Samaha, Mia C., primary, Hu, Kevin, primary, Bick, Nolan R., primary, Siddiqui, Javed, primary, Hovelson, Daniel H., primary, Liu, Chia-Jen, primary, Carter, Cody S., primary, Cho, Kathleen R., primary, Sciallis, Andrew P., primary, and Tomlins, Scott A., primary

Published
2023
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72. Supplementary Figures 1-3 from Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab

Author

Kurdi, Ahmed T., primary, Glavey, Siobhan V., primary, Bezman, Natalie A., primary, Jhatakia, Amy, primary, Guerriero, Jennifer L., primary, Manier, Salomon, primary, Moschetta, Michele, primary, Mishima, Yuji, primary, Roccaro, Aldo, primary, Detappe, Alexandre, primary, Liu, Chia-Jen, primary, Sacco, Antonio, primary, Huynh, Daisy, primary, Tai, Yu-Tzu, primary, Robbins, Michael D., primary, Azzi, Jamil, primary, and Ghobrial, Irene M., primary

Published
2023
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81. Data from Comprehensive Mutation and Copy Number Profiling in Archived Circulating Breast Cancer Tumor Cells Documents Heterogeneous Resistance Mechanisms

Author

Paoletti, Costanza, primary, Cani, Andi K., primary, Larios, Jose M., primary, Hovelson, Daniel H., primary, Aung, Kimberly, primary, Darga, Elizabeth P., primary, Cannell, Emily M., primary, Baratta, Paul J., primary, Liu, Chia-Jen, primary, Chu, David, primary, Yazdani, Maryam, primary, Blevins, Allen R., primary, Sero, Valeria, primary, Tokudome, Nahomi, primary, Thomas, Dafydd G., primary, Gersch, Christina, primary, Schott, Anne F., primary, Wu, Yi-Mi, primary, Lonigro, Robert, primary, Robinson, Dan R., primary, Chinnaiyan, Arul M., primary, Bischoff, Farideh Z., primary, Johnson, Michael D., primary, Park, Ben H., primary, Hayes, Daniel F., primary, Rae, James M., primary, and Tomlins, Scott A., primary

Published
2023
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82. Fig S6 from Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation

Author

Takagi, Satoshi, primary, Tsukamoto, Shokichi, primary, Park, Jihye, primary, Johnson, Kelly E., primary, Kawano, Yawara, primary, Moschetta, Michele, primary, Liu, Chia-Jen, primary, Mishima, Yuji, primary, Kokubun, Katsutoshi, primary, Manier, Salomon, primary, Salem, Karma Z., primary, Huynh, Daisy, primary, Sacco, Antonio, primary, Forward, Jodi, primary, Roccaro, Aldo M., primary, Battinelli, Elisabeth M., primary, and Ghobrial, Irene M., primary

Published
2023
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83. Supplementary Figure S8 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts

Author

McCool, Kevin W., primary, Freeman, Zachary T., primary, Zhai, Yali, primary, Wu, Rong, primary, Hu, Kevin, primary, Liu, Chia-Jen, primary, Tomlins, Scott A., primary, Fearon, Eric R., primary, Magnuson, Brian, primary, Kuick, Rork, primary, and Cho, Kathleen R., primary

Published
2023
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84. Supplementary Table 1 from Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation

Author

Takagi, Satoshi, primary, Tsukamoto, Shokichi, primary, Park, Jihye, primary, Johnson, Kelly E., primary, Kawano, Yawara, primary, Moschetta, Michele, primary, Liu, Chia-Jen, primary, Mishima, Yuji, primary, Kokubun, Katsutoshi, primary, Manier, Salomon, primary, Salem, Karma Z., primary, Huynh, Daisy, primary, Sacco, Antonio, primary, Forward, Jodi, primary, Roccaro, Aldo M., primary, Battinelli, Elisabeth M., primary, and Ghobrial, Irene M., primary

Published
2023
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85. Supplementary Data 3 from A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma

Author

Ghobrial, Irene M., primary, Liu, Chia-Jen, primary, Redd, Robert A., primary, Perez, Raymond P., primary, Baz, Rachid, primary, Zavidij, Oksana, primary, Sklavenitis-Pistofidis, Romanos, primary, Richardson, Paul G., primary, Anderson, Kenneth C., primary, Laubach, Jacob, primary, Henrick, Patrick, primary, Savell, Alexandra, primary, Reyes, Kaitlen, primary, Hornburg, Kalvis, primary, Chuma, Stacey, primary, Sabbatini, Peter, primary, Robbins, Michael D., primary, and Becker, Pamela S., primary

Published
2023
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86. Supplementary Data from Comprehensive Mutation and Copy Number Profiling in Archived Circulating Breast Cancer Tumor Cells Documents Heterogeneous Resistance Mechanisms

Author

Paoletti, Costanza, primary, Cani, Andi K., primary, Larios, Jose M., primary, Hovelson, Daniel H., primary, Aung, Kimberly, primary, Darga, Elizabeth P., primary, Cannell, Emily M., primary, Baratta, Paul J., primary, Liu, Chia-Jen, primary, Chu, David, primary, Yazdani, Maryam, primary, Blevins, Allen R., primary, Sero, Valeria, primary, Tokudome, Nahomi, primary, Thomas, Dafydd G., primary, Gersch, Christina, primary, Schott, Anne F., primary, Wu, Yi-Mi, primary, Lonigro, Robert, primary, Robinson, Dan R., primary, Chinnaiyan, Arul M., primary, Bischoff, Farideh Z., primary, Johnson, Michael D., primary, Park, Ben H., primary, Hayes, Daniel F., primary, Rae, James M., primary, and Tomlins, Scott A., primary

Published
2023
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88. Supplementary material from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer

Author

Palapattu, Ganesh S., primary, Salami, Simpa S., primary, Cani, Andi K., primary, Hovelson, Daniel H., primary, Lazo de la Vega, Lorena, primary, Vandenberg, Kelly R., primary, Bratley, Jarred V., primary, Liu, Chia-Jen, primary, Kunju, Lakshmi P., primary, Montgomery, Jeffery S., primary, Morgan, Todd M., primary, Natarajan, Shyam, primary, Huang, Jiaoti, primary, Tomlins, Scott A., primary, and Marks, Leonard S., primary

Published
2023
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89. Table S1 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts

Author

McCool, Kevin W., primary, Freeman, Zachary T., primary, Zhai, Yali, primary, Wu, Rong, primary, Hu, Kevin, primary, Liu, Chia-Jen, primary, Tomlins, Scott A., primary, Fearon, Eric R., primary, Magnuson, Brian, primary, Kuick, Rork, primary, and Cho, Kathleen R., primary

Published
2023
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90. Supplementary Methods from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts

Author

McCool, Kevin W., primary, Freeman, Zachary T., primary, Zhai, Yali, primary, Wu, Rong, primary, Hu, Kevin, primary, Liu, Chia-Jen, primary, Tomlins, Scott A., primary, Fearon, Eric R., primary, Magnuson, Brian, primary, Kuick, Rork, primary, and Cho, Kathleen R., primary

Published
2023
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91. Supplementary Methods and References from Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy

Author

McDaniel, Andrew S., primary, Hovelson, Daniel H., primary, Cani, Andi K., primary, Liu, Chia-Jen, primary, Zhai, Yali, primary, Zhang, Yajia, primary, Weizer, Alon Z., primary, Mehra, Rohit, primary, Feng, Felix Y., primary, Alva, Ajjai S., primary, Morgan, Todd M., primary, Montgomery, Jeffrey S., primary, Siddiqui, Javed, primary, Sadis, Seth, primary, Bandla, Santhoshi, primary, Williams, Paul D., primary, Cho, Kathleen R., primary, Rhodes, Daniel R., primary, and Tomlins, Scott A., primary

Published
2023
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92. Data from Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy

Author

McDaniel, Andrew S., primary, Hovelson, Daniel H., primary, Cani, Andi K., primary, Liu, Chia-Jen, primary, Zhai, Yali, primary, Zhang, Yajia, primary, Weizer, Alon Z., primary, Mehra, Rohit, primary, Feng, Felix Y., primary, Alva, Ajjai S., primary, Morgan, Todd M., primary, Montgomery, Jeffrey S., primary, Siddiqui, Javed, primary, Sadis, Seth, primary, Bandla, Santhoshi, primary, Williams, Paul D., primary, Cho, Kathleen R., primary, Rhodes, Daniel R., primary, and Tomlins, Scott A., primary

Published
2023
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93. Supplementary Figures S1-S5 from Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy

Author

McDaniel, Andrew S., primary, Hovelson, Daniel H., primary, Cani, Andi K., primary, Liu, Chia-Jen, primary, Zhai, Yali, primary, Zhang, Yajia, primary, Weizer, Alon Z., primary, Mehra, Rohit, primary, Feng, Felix Y., primary, Alva, Ajjai S., primary, Morgan, Todd M., primary, Montgomery, Jeffrey S., primary, Siddiqui, Javed, primary, Sadis, Seth, primary, Bandla, Santhoshi, primary, Williams, Paul D., primary, Cho, Kathleen R., primary, Rhodes, Daniel R., primary, and Tomlins, Scott A., primary

Published
2023
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94. Supplementary Figure Legends from Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy

Author

McDaniel, Andrew S., primary, Hovelson, Daniel H., primary, Cani, Andi K., primary, Liu, Chia-Jen, primary, Zhai, Yali, primary, Zhang, Yajia, primary, Weizer, Alon Z., primary, Mehra, Rohit, primary, Feng, Felix Y., primary, Alva, Ajjai S., primary, Morgan, Todd M., primary, Montgomery, Jeffrey S., primary, Siddiqui, Javed, primary, Sadis, Seth, primary, Bandla, Santhoshi, primary, Williams, Paul D., primary, Cho, Kathleen R., primary, Rhodes, Daniel R., primary, and Tomlins, Scott A., primary

Published
2023
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95. Supplementary Tables S1-S4 from Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy

Author

McDaniel, Andrew S., primary, Hovelson, Daniel H., primary, Cani, Andi K., primary, Liu, Chia-Jen, primary, Zhai, Yali, primary, Zhang, Yajia, primary, Weizer, Alon Z., primary, Mehra, Rohit, primary, Feng, Felix Y., primary, Alva, Ajjai S., primary, Morgan, Todd M., primary, Montgomery, Jeffrey S., primary, Siddiqui, Javed, primary, Sadis, Seth, primary, Bandla, Santhoshi, primary, Williams, Paul D., primary, Cho, Kathleen R., primary, Rhodes, Daniel R., primary, and Tomlins, Scott A., primary

Published
2023
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96. Abstract P4-02-04: Serial monitoring of circulating tumor cells and circulating tumor DNA in metastatic lobular breast cancer identifies intra-tumor heterogeneity and precision and immuno-oncology biomarkers of therapeutic importance

Author

Cani, Andi, primary, Dolce, Emily, additional, Turnbull, Alissa, additional, Hu, Kevin, additional, Liu, Chia-Jen, additional, Darga, Elizabeth, additional, Robinson, Dan, additional, Wu, Yi-Mi, additional, Thomas, Dafydd G., additional, Paoletti, Costanza, additional, Tomlins, Scott, additional, Rae, James, additional, Udager, Aaron, additional, Chinnaiyan, Arul, additional, Cobain, Erin F., additional, and Hayes, Daniel F., additional

Published
2023
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98. Long‐term outcomes of frontline intensification in primary CNS lymphoma: A real‐world single‐center experience

Author

Wang, Hao‐Yuan, primary, Yang, Ching‐Fen, additional, Lin, Chia‐Hsin, additional, Hsiao, Liang‐Tsai, additional, Ko, Po‐Shen, additional, Liu, Yao‐Chung, additional, Chiou, Tzeon‐Jye, additional, Chen, Po‐Min, additional, Gau, Jyh‐Pyng, additional, Liu, Jin‐Hwang, additional, and Liu, Chia‐Jen, additional

Published
2023
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