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52. AHEAD score — Long-term risk classification in acute heart failure

Author

Spinar, Jindrich, Jarkovsky, Jiri, Spinarova, Lenka, Mebazaa, Alexandre, Gayat, Etienne, Vitovec, Jiri, Linhart, Ales, Widimsky, Petr, Miklik, Roman, Zeman, Kamil, Belohlavek, Jan, Malek, Filip, Felsoci, Marian, Kettner, Jiri, Ostadal, Petr, Cihalik, Cestmir, Vaclavik, Jan, Taborsky, Miloš, Dusek, Ladislav, Littnerova, Simona, and Parenica, Jiri

Published
2016
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53. State-of-the-art document on optimal contemporary management of cardiomyopathies

Author

Seferović, Petar M., Polovina, Marija, Rosano, Giuseppe, Bozkurt, Biykem, Metra, Marco, Heymans, Stephane, Mullens, Wilfried, Bauersachs, Johann, Sliwa, Karen, de Boer, Rudolf A., Farmakis, Dimitrios, Thum, Thomas, Olivotto, Iacopo, Rapezzi, Claudio, Linhart, Aleš, Corrado, Domenico, Tschöpe, Carsten, Milinković, Ivan, Bayes Genis, Antoni, Filippatos, Gerasimos, Keren, Andre, Ašanin, Milika, Krljanac, Gordana, Maksimović, Ružica, Skouri, Hadi, Ben Gal, Tuvia, Moura, Brenda, Volterrani, Maurizio, Abdelhamid, Magdy, Lopatin, Yuri, Chioncel, Ovidiu, Coats, Andrew J.S., Seferović, Petar M., Polovina, Marija, Rosano, Giuseppe, Bozkurt, Biykem, Metra, Marco, Heymans, Stephane, Mullens, Wilfried, Bauersachs, Johann, Sliwa, Karen, de Boer, Rudolf A., Farmakis, Dimitrios, Thum, Thomas, Olivotto, Iacopo, Rapezzi, Claudio, Linhart, Aleš, Corrado, Domenico, Tschöpe, Carsten, Milinković, Ivan, Bayes Genis, Antoni, Filippatos, Gerasimos, Keren, Andre, Ašanin, Milika, Krljanac, Gordana, Maksimović, Ružica, Skouri, Hadi, Ben Gal, Tuvia, Moura, Brenda, Volterrani, Maurizio, Abdelhamid, Magdy, Lopatin, Yuri, Chioncel, Ovidiu, and Coats, Andrew J.S.

Abstract

Cardiomyopathies represent significant contributors to cardiovascular morbidity and mortality. Over the past decades, a progress has occurred in characterization of the genetic background and major pathophysiological mechanisms, which has been incorporated into a more nuanced diagnostic approach and risk stratification. Furthermore, medications targeting core disease processes and/or their downstream adverse effects have been introduced for several cardiomyopathies. Combined with standard care and prevention of sudden cardiac death, these novel and emerging targeted therapies offer a possibility of improving the outcomes in several cardiomyopathies. Therefore, the aim of this document is to summarize practical approaches to the treatment of cardiomyopathies, which includes the evidence-based novel therapeutic concepts and established principles of care, tailored to the individual patient aetiology and clinical presentation of the cardiomyopathy. The scope of the document encompasses contemporary treatment of dilated, hypertrophic, restrictive and arrhythmogenic cardiomyopathy. It was based on an expert consensus reached at the Heart Failure Association online Workshop, held on 18 March 2021.

Published
2023

56. Coronary CT angiography

Author

Kuchynka, Petr, Lambert, Lukáš, Černý, Vladimír, Marek, Josef, Ambrož, David, Danek, Barbara Anna, and Linhart, Aleš

Published
2015
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62. (Multicentric Observational prospective cohort STudy of the Heart Failure outpatients management in the Czech Republic - MOST-HF. Rationale and Design)

Author

Málek, Filip, primary, Táborský, Miloš, additional, Málek, Ivan, additional, Paleček, Tomáš, additional, Špinarová, Lenka, additional, Vítovec, Jiří, additional, Špinar, Jindřich, additional, Melenovský, Vojtěch, additional, Krejčí, Jan, additional, Linhart, Aleš, additional, Pudil, Radek, additional, Ošťádal, Petr, additional, Veselý, Jiří, additional, Kubátová, Jana, additional, and Unar Vinklerová, Jana, additional

Published
2022
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64. P005: Head-to-head trial of pegunigalsidase alfa vs agalsidase beta in Fabry disease: Phase 3 randomized, double-blind, BALANCE Study 2-year results

Author

Bernat, John, Wallace, Eric, Goker-Alpan, Ozlem, Wilcox, William, Holida, Myrl, Longo, Nicola, Hughes, Derralynn, Giraldo, Pilar, Molnar, Maria, Ortiz, Damara, Hopkin, Robert, Tondel, Camilla, Linhart, Ales, Deegan, Patrick, Jovanovic, Ana, Muriello, Michael, Barshop, Bruce, Kimonis, Virginia, Vujkovac, Bojan, Nowak, Albina, Hiwot, Tarekegn, Pisani, Antonio, Germain, Dominique, Kantola, Ilkka, Knoll, Jasmine, Mehta, Ankit, Waldek, Stephen, Almon, Einat, Alon, Sari, Chertkoff, Raul, Rocco, Rossana, and Warnock, David

Published
2023
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65. P006: Long-term safety and efficacy of pegunigalsidase alfa administered every 4 weeks in Fabry disease: 2-Year interim results from BRIGHT51

Author

Bernat, John, Holida, Myrl, Longo, Nicola, Goker-Alpan, Ozlem, Wallace, Eric, Deegan, Patrick, Tondel, Camilla, Eyskens, Francois, Feldt-Rasmussen, Ulla, Hughes, Derralynn, Pisani, Antonio, Linhart, Ales, Rocco, Rossana, Almon, Einat, Alon, Sari, Chertkoff, Raul, Warnock, David, Waldek, Stephen, and Wilcox, William

Published
2023
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66. Polypill Strategy in Secondary Cardiovascular Prevention

Author

Castellano, Jose M, Pocock, Stuart J, Bhatt, Deepak L, Quesada, Antonio J, Owen, Ruth, Fernandez-Ortiz, Antonio, Sanchez, Pedro L, Marin Ortuño, Francisco, Vazquez Rodriguez, Jose M, Domingo-Fernández, Alexandra, Lozano, Iñigo, Roncaglioni, Maria C, Baviera, Marta, Foresta, Andreana, Ojeda-Fernandez, Luisa, Colivicchi, Furio, Di Fusco, Stefania A, Doehner, Wolfram, Meyer, Antje, Schiele, François, Ecarnot, Fiona, Linhart, Aleš, Lubanda, Jean-Claude, Barczi, Gyorgy, Merkely, Bela, Ponikowski, Piotr, Kasprzak, Marta, Fernandez Alvira, Juan M, Andres, Vicente, Bueno, Hector, Collier, Timothy, Van de Werf, Frans, Perel, Pablo, Rodriguez-Manero, Moises, Alonso Garcia, Angeles, Proietti, Marco, Schoos, Mikkel M, Simon, Tabassome, Fernandez Ferro, Jose, Lopez, Nicolas, Beghi, Ettore, Bejot, Yannick, Vivas, David, Cordero, Alberto, Ibañez, Borja, Fuster, Valentin, and SECURE Investigators

Subjects
Aspirin, Ramipril, Cardiovascular Diseases, Atorvastatin, Myocardial Infarction, Secondary Prevention, Humans, Angiotensin-Converting Enzyme Inhibitors, General Medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Platelet Aggregation Inhibitors, Ischemic Stroke
Abstract

BACKGROUND: A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting-enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death and complications after myocardial infarction. METHODS: In this phase 3, randomized, controlled clinical trial, we assigned patients with myocardial infarction within the previous 6 months to a polypill-based strategy or usual care. The polypill treatment consisted of aspirin (100 mg), ramipril (2.5, 5, or 10 mg), and atorvastatin (20 or 40 mg). The primary composite outcome was cardiovascular death, nonfatal type 1 myocardial infarction, nonfatal ischemic stroke, or urgent revascularization. The key secondary end point was a composite of cardiovascular death, nonfatal type 1 myocardial infarction, or nonfatal ischemic stroke. RESULTS: A total of 2499 patients underwent randomization and were followed for a median of 36 months. A primary-outcome event occurred in 118 of 1237 patients (9.5%) in the polypill group and in 156 of 1229 (12.7%) in the usual-care group (hazard ratio, 0.76; 95% confidence interval [CI], 0.60 to 0.96; P = 0.02). A key secondary-outcome event occurred in 101 patients (8.2%) in the polypill group and in 144 (11.7%) in the usual-care group (hazard ratio, 0.70; 95% CI, 0.54 to 0.90; P = 0.005). The results were consistent across prespecified subgroups. Medication adherence as reported by the patients was higher in the polypill group than in the usual-care group. Adverse events were similar between groups. CONCLUSIONS: Treatment with a polypill containing aspirin, ramipril, and atorvastatin within 6 months after myocardial infarction resulted in a significantly lower risk of major adverse cardiovascular events than usual care. (Funded by the European Union Horizon 2020; SECURE ClinicalTrials.gov number, NCT02596126; EudraCT number, 2015-002868-17.).

Published
2022
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67. Longitudinal trends in blood pressure, prevalence, awareness, treatment, and control of hypertension in the Czech population. Are there any sex differences?

Author

Cífková, Renata, primary, Bruthans, Jan, additional, Strilchuk, Larysa, additional, Wohlfahrt, Peter, additional, Krajčoviechová, Alena, additional, Šulc, Pavel, additional, Jozífová, Marie, additional, Eremiášová, Lenka, additional, Pudil, Jan, additional, Linhart, Aleš, additional, Widimský, Jiří, additional, Filipovský, Jan, additional, Mayer, Otto, additional, Škodová, Zdenka, additional, and Lánská, Věra, additional

Published
2022
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69. Hospitalisation Is Prognostic of Survival in Chronic Thromboembolic Pulmonary Hypertension

Author

Jansa, Pavel, primary, Ambrož, David, additional, Aschermann, Michael, additional, Černý, Vladimír, additional, Dytrych, Vladimír, additional, Heller, Samuel, additional, Kunstýř, Jan, additional, Lindner, Jaroslav, additional, Linhart, Aleš, additional, Nižnanský, Matúš, additional, Paďour, Michal, additional, Prskavec, Tomáš, additional, Širanec, Michal, additional, Edwards, Susan, additional, Gressin, Virginie, additional, Kuhn, Matyáš, additional, and Di Scala, Lilla, additional

Published
2022
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70. AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?

Author

Živná, Martina, primary, Dostálová, Gabriela, additional, Barešová, Veronika, additional, Mušálková, Dita, additional, Kuchař, Ladislav, additional, Asfaw, Befekadu, additional, Poupětová, Helena, additional, Vlášková, Hana, additional, Kmochová, Tereza, additional, Vyletal, Petr, additional, Hartmannová, Hana, additional, Hodaňová, Kateřina, additional, Stránecký, Viktor, additional, Steiner-Mrázová, Lenka, additional, Hnízda, Aleš, additional, Radina, Martin, additional, Votruba, Miroslav, additional, Sovová, Jana, additional, Trešlová, Helena, additional, Stolnaja, Larisa, additional, Reková, Petra, additional, Roblová, Lenka, additional, Honsová, Eva, additional, Hůlková, Helena, additional, Rychlík, Ivan, additional, Bleyer, Anthony J., additional, Linhart, Aleš, additional, Sikora, Jakub, additional, and Kmoch, Stanislav, additional

Published
2022
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71. Nationwide screening of Fabry disease in patients with hypertrophic cardiomyopathy in Czech Republic

Author

Zemánek, David, primary, Januška, Jaroslav, additional, Honěk, Tomáš, additional, Čurila, Karol, additional, Kubánek, Miloš, additional, Šindelářová, Štěpánka, additional, Zahálková, Lucie, additional, Klofáč, Petr, additional, Laštůvková, Eliška, additional, Lichnerová, Eva, additional, Aiglová, Renata, additional, Lhotský, Jan, additional, Vondrák, Jiří, additional, Dostálová, Gabriela, additional, Táborský, Miloš, additional, Kasper, David, additional, and Linhart, Aleš, additional

Published
2022
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72. Analysis of left ventricular mass in untreated men and in men treated with agalsidase-β: data from the Fabry Registry

Author

Germain, Dominique P., Weidemann, Frank, Abiose, Ademola, Patel, Manesh R., Cizmarik, Marta, Cole, J. Alexander, Beitner-Johnson, Dana, Benistan, Karelle, Cabrera, Gustavo, Charrow, Joel, Kantola, Ilkka, Linhart, Ales, Nicholls, Kathy, Niemann, Markus, Scott, C. Ronald, Sims, Katherine, Waldek, Stephen, Warnock, David G., and Strotmann, Jörg

Published
2013
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74. Risk of in-hospital mortality identified according to the typology of patients with acute heart failure: Classification tree analysis on data from the Acute Heart Failure Database–Main registry

Author

Tomcikova, Daniela, Felsoci, Marian, Spinar, Jindrich, Miklik, Roman, Mikusova, Tereza, Vitovec, Jiri, Spinarova, Lenka, Widimsky, Petr, Linhart, Ales, Belohlavek, Jan, Fedorco, Marian, Cihalik, Cestmir, Malek, Filip, Bambuch, Miroslav, Vaclavik, Jan, Kettner, Jiri, Jarkovsky, Jiri, Dusek, Ladislav, and Parenica, Jiri

Published
2013
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78. Polypill Strategy in Secondary Cardiovascular Prevention

Author

Castellano, Jose M., Pocock, Stuart J., Bhatt, Deepak L., Quesada, Antonio J., Owen, Ruth, Fernandez-Ortiz, Antonio, Sanchez, Pedro L., Ortuño, Francisco Marin, Vazquez Rodriguez, Jose M., Domingo-Fernández, Alexandra, Lozano, Iñigo, Roncaglioni, Maria C., Baviera, Marta, Foresta, Andreana, Ojeda-Fernandez, Luisa, Colivicchi, Furio, Di Fusco, Stefania A., Doehner, Wolfram, Meyer, Antje, Schiele, François, Ecarnot, Fiona, Linhart, Aleš, Lubanda, Jean Claude, Barczi, Gyorgy, Merkely, Bela, Ponikowski, Piotr, Kasprzak, Marta, Fernandez Alvira, Juan M., Andres, Vicente, Bueno, Hector, Collier, Timothy, Van de Werf, Frans, Perel, Pablo, Rodriguez-Manero, Moises, Garcia, Angeles Alonso, Proietti, Marco, Schoos, Mikkel M., Simon, Tabassome, Ferro, Jose Fernandez, Lopez, Nicolas, Beghi, Ettore, Bejot, Yannick, Vivas, David, Cordero, Alberto, Ibañez, Borja, Fuster, Valentin, Castellano, Jose M., Pocock, Stuart J., Bhatt, Deepak L., Quesada, Antonio J., Owen, Ruth, Fernandez-Ortiz, Antonio, Sanchez, Pedro L., Ortuño, Francisco Marin, Vazquez Rodriguez, Jose M., Domingo-Fernández, Alexandra, Lozano, Iñigo, Roncaglioni, Maria C., Baviera, Marta, Foresta, Andreana, Ojeda-Fernandez, Luisa, Colivicchi, Furio, Di Fusco, Stefania A., Doehner, Wolfram, Meyer, Antje, Schiele, François, Ecarnot, Fiona, Linhart, Aleš, Lubanda, Jean Claude, Barczi, Gyorgy, Merkely, Bela, Ponikowski, Piotr, Kasprzak, Marta, Fernandez Alvira, Juan M., Andres, Vicente, Bueno, Hector, Collier, Timothy, Van de Werf, Frans, Perel, Pablo, Rodriguez-Manero, Moises, Garcia, Angeles Alonso, Proietti, Marco, Schoos, Mikkel M., Simon, Tabassome, Ferro, Jose Fernandez, Lopez, Nicolas, Beghi, Ettore, Bejot, Yannick, Vivas, David, Cordero, Alberto, Ibañez, Borja, and Fuster, Valentin

Abstract

BACKGROUND A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting–enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death and complications after myocardial infarction. METHODS In this phase 3, randomized, controlled clinical trial, we assigned patients with myocardial infarction within the previous 6 months to a polypill-based strategy or usual care. The polypill treatment consisted of aspirin (100 mg), ramipril (2.5, 5, or 10 mg), and atorvastatin (20 or 40 mg). The primary composite outcome was cardiovascular death, nonfatal type 1 myocardial infarction, nonfatal ischemic stroke, or urgent revascularization. The key secondary end point was a composite of cardiovascular death, nonfatal type 1 myocardial infarction, or nonfatal ischemic stroke. RESULTS A total of 2499 patients underwent randomization and were followed for a median of 36 months. A primary-outcome event occurred in 118 of 1237 patients (9.5%) in the polypill group and in 156 of 1229 (12.7%) in the usual-care group (hazard ratio, 0.76; 95% confidence interval [CI], 0.60 to 0.96; P=0.02). A key secondary-outcome event occurred in 101 patients (8.2%) in the polypill group and in 144 (11.7%) in the usual-care group (hazard ratio, 0.70; 95% CI, 0.54 to 0.90; P=0.005). The results were consistent across prespecified subgroups. Medication adherence as reported by the patients was higher in the polypill group than in the usual-care group. Adverse events were similar between groups. CONCLUSIONS Treatment with a polypill containing aspirin, ramipril, and atorvastatin within 6 months after myocardial infarction resulted in a significantly lower risk of major adverse cardiovascular events than usual care.

Published
2022

81. Pitfalls of X‐chromosome inactivation testing in females with Fabry disease

Author

Řeboun, Martin, primary, Sikora, Jakub, additional, Magner, Martin, additional, Wiederlechnerová, Helena, additional, Černá, Alena, additional, Poupětová, Helena, additional, Štorkánova, Gabriela, additional, Mušálková, Dita, additional, Dostálová, Gabriela, additional, Goláň, Lubor, additional, Linhart, Aleš, additional, and Dvořáková, Lenka, additional

Published
2022
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84. Iatrogenní disekce aorty jako komplikace perkutánních koronárních intervencí.

Author

Horáková, Johana, Král, Aleš, Procházka, Pavel, and Linhart, Aleš

Abstract

Copyright of Intervencní a Akutní Kardiologie is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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85. Endovaskulární léčba syndromu pánevní kongesce.

Author

Procházka, Pavel, Kučerák, Jozef, Ambrož, David, Horáková, Johana, Bělohlávek, Jan, and Linhart, Aleš

Abstract

Copyright of Intervencní a Akutní Kardiologie is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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88. (Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA). Translation of the document prepared by the Czech Society of Cardiology)

Author

Táborský, Miloš, primary, Linhart, Aleš, additional, Kautzner, Josef, additional, Ošťádal, Petr, additional, Moťovská, Zuzana, additional, Hutyra, Martin, additional, Pudil, Radek, additional, Bělohlávek, Jan, additional, and Aschermann, Michael, additional

Published
2022
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90. Epidemiology of chronic thromboembolic pulmonary hypertension (CTEPH) in the Czech Republic

Author

Jansa, Pavel, primary, Ambrož, David, additional, Kuhn, Matyáš, additional, Dytrych, Vladimír, additional, Aschermann, Michael, additional, Černý, Vladimír, additional, Gressin, Virginie, additional, Heller, Samuel, additional, Kunstýř, Jan, additional, Širanec, Michal, additional, Song, Ci, additional, Linhart, Aleš, additional, Lindner, Jaroslav, additional, and Muller, Audrey, additional

Published
2022
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92. (Antithrombotic therapies in aortic and peripheral arterial diseases in 2021: a consensus document from the ESC working group on aorta and peripheral vascular diseases, the ESC working group on thrombosis, and the ESC working group on cardiovascular pharmacotherapy. Translation of the document prepared by the Czech Society of Cardiology and the Czech Society of Angiology of ČLS JEP)

Author

Táborský, Miloš, primary, Linhart, Aleš, additional, Karetová, Debora, additional, Skála, Tomáš, additional, Moťovská, Zuzana, additional, Köcher, Martin, additional, and Štádler, Petr, additional

Published
2021
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94. (Practical aspects of establishing of heart failure clinics)

Author

Málek, Filip, primary, Málek, Ivan, additional, Táborský, Miloš, additional, Vítovec, Jiří, additional, Krejčí, Jan, additional, Špinarová, Lenka, additional, Špinar, Jindřich, additional, Paleček, Tomáš, additional, Veselý, Jiří, additional, Melenovský, Vojtěch, additional, Pudil, Radek, additional, Ošťádal, Petr, additional, and Linhart, Aleš, additional

Published
2021
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