Search

Your search keyword '"Linhares, Alexandre"' showing total 712 results
Start Over Author "Linhares, Alexandre"
712 results on '"Linhares, Alexandre"'

51. How can experts see the invisible? Reply to Bilalic and Gobet

Author

Linhares, Alexandre and Brum, Paulo

Subjects
Psychology and mental health
Abstract

Experts in all fields are able to see what is invisible to others. Experts are also able to see what is visible to all--and this is explored by Bilalic and Gobet. We question the method of normalizing all subjects in an experimental condition, and asking experts to behave as if they were novices. We claim that method leads Bilalic and Gobet to a nonsequitur. Keywords: Decision-making; Perception: Representation: Problem-solving; Chunking; Abstract vision

Published
2009

54. Phylogenetic analysis of probable Non-human genes of group A rotaviruses isolated from children with acute gastroenteritis in Belém, Brazil

Author

Maestri, Régis Piloni, Kaiano, Jane Haruko Lima, Neri, Darivaldo Luz, da Silva Soares, Luana, dos Santos Guerra, Sylvia de Fatima, de Souza Oliveira, Darleise, Farias, Yasmin Nascimento, Gabbay, Yvone Benchimol, Leite, José Paulo Gagliardi, da Costa Linhares, Alexandre, and Mascarenhas, Joana DʼArc Pereira

Published
2012
Full Text
View/download PDF

55. Detection of a novel species A, DS‐1‐like, G4P[6] rotavirus strain from a Brazilian child with gastroenteritis.

Author

Bandeira, Renato da Silva, Souto, Lizandra Caroline dos Santos, de Souza, Layse Costa, Linhares, Alexandre C., and Mascarenhas, Joana D'Arc Pereira

Subjects
GENETIC variation, GASTROENTERITIS, ROTAVIRUSES, SPECIES, GENOTYPES
Abstract

Rotaviruses belonging to species A (RVA) remain among the most common causes of severe gastroenteritis in children aged <5 years, leading to substantial morbidity and mortality worldwide. Genome reassortment events between two human strains or human and animal strains represent one of the mechanisms which appear to generate the broad genetic variability of circulating. According to a nucleotide, sequence‐based classification system, RVA strains are currently classified into three genotype constellations including Wa‐like (genogroup I), DS‐1‐like (genogroup II), and AU‐like (genogroup III). The present study reports the detection of an unusual RVA G4P[6] strain (coded as strain HSE005), which might have originated from a natural reassortment event between human and animal RVA strains. Molecular characterization of this isolate showed that it belonged to genogroup II, genotype G4P[6]. In addition, two genes (VP3 and NSP4) of this strain denoted evidence of reassortment events involving strains of distinct zoonotic evolutionary origins. Therefore, we propose that a new G4P[6] strain was identified, highlighting a possible first zoonotic transmission including a reassortment event that involved the VP3 gene. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

59. Detection of Zoonotic Rotavirus Transmission involving a Rare Genotype G3P[3] in the Amazon Region: A Phylodynamic Approach with Multiple Events of Reassortment and Evolutionary Origin

Author

da Silva Bandeira, Renato, primary, Santos Souto, Lizandra Caroline dos, additional, de Souza, Layse Costa, additional, Melo Bezerra, Delana Andreza, additional, Lemos, Poliana da Silva, additional, Linhares, Alexandre C., additional, and Pereira Mascarenhas, Joana D'Arc, additional

Published
2019
Full Text
View/download PDF

60. Linear gate assignment: a fast statistical mechanics approach

Author

Linhares, Alexandre, Yanasse, Horacio H., and Torreao, Jose R.A.

Subjects
Linear models (Statistics) -- Methods, Computer systems integration -- Models, Gate arrays -- Design and construction, Heuristic programming -- Models, Statistical mechanics -- Models
Published
1999

66. Additional file 1: of Rotavirus antigenemia as a common event among children hospitalised for severe, acute gastroenteritis in Belém, northern Brazil

Author

Justino, Maria Cleonice, Campos, Erika, Mascarenhas, Joana D’arc, Soares, Luana, Guerra, Sylvia De Fátima, Ismari Furlaneto, Pavão, Manoel Jaime, Tassio Maciel, Fredison Farias, Orvácio Bezerra, Vinente, Caio Breno, Barros, Rodrigo José, and Linhares, Alexandre

Subjects
fluids and secretions, viruses, virus diseases
Abstract

Figure S1. Agarose gel electrophoresis of RT-PCR VP7 (A) and VP4 (B) gene products obtained from the sera of ten rotavirus-positive children with gastroenteritis in Belém, Brazil. (PPTX 121 kb)

Published
2019
Full Text
View/download PDF

67. Instituto Evandro Chagas: ci?ncia e tecnologia a servi?o da vigil?ncia em sa?de p?blica

Author

Primo, Mara Barroso, Jocundo, Susana M. Y, Souza, Cintya de Oliveira, Cavalcante, Gilmara Abreu da Silva, Nunes, Heloisa Marceliano, Carneiro, Bruno Santana, Morais, Rafaela dos Anjos Pinheiro Bogoevich, Martins Filho, Arnaldo Jorge, Linhares, Alexandre da Costa, Ramos, Francisco L?zio de Paula, Guimar?es, Ricardo Jos? de Paula Souza e, Pican?o Junior, Jos? Antonio Diniz, Mascarenhas, Joana D?Arc Pereira, Soares, Daniela Cristina, Vieira, Lorena Drumond Loureiro, Matos, Luanna Ematne de, Lima, Marcelo de Oliveira, Silvestre, Rodrigo Vellasco Duarte, Bastos, F?bio Augusto da Silva, Souza, Kelvin Santos de, Sagica, Fernanda do Espirito Santo, Martins, Livia Car?cio, Carneiro, Liliane Almeida, and Viana, Giselle Maria Rachid

Subjects
Instala??es de Sa?de / hist?ria, Academias e Institutos / organiza??o & administra??o, Academias e Institutos / hist?ria, Regi?o Amaz?nica (BR)
Abstract

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Assessoria de Planejamento. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Assessoria de Planejamento. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Assessoria de Planejamento. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Assessoria de Comunica??o. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Assessoria de Comunica??o. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro Nacional de Primatas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Published
2019

70. Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis

Author

Ruiz-Palacios, Guillermo M., Perez-Schael, Irene, Velazquez, F. Raul, Abate, Hector, Breuer, Thomas, Clemens, SueAnn Costa, Cheuvart, Brigitte, Espinoza, Felix, Gillard, Paul, Innis, Bruce L., Cervantes, Yolanda, Linhares, Alexandre C., Lopez, Pio, Macias-Parra, Mercedes, Ortega-Barria, Eduardo, Richardson, Vesta, Rivera-Medina, Doris Maribel, Rivera, Luis, Salinas, Belen, Pavia-Ruz, Noris, Salmeron, Jorge, Ruttimann, Ricardo, Tinoco, Juan Carlos, Rubio, Pilar, Nunez, Ernesto, Guerrero, M. Lourdes, Yarzabal, Juan Pablo, Damaso, Silvia, Tornieporth, Nadia, Saez-Llorens, Xavier, Vergara, Rodrigo F., Vesikari, Timo, Bouckenooghe, Alain, Clemens, Ralf, De Vos, Beatrice, and O'Ryan, Miguel

Published
2006

71. Priming and Prejudice: The Bias Effect of Origin Information on Peer Review, Judgment and Evaluation

Author

Victorino, Luiz, Pilati, Ronaldo, Linhares, Alexandre, Victorino, Luiz, Pilati, Ronaldo, and Linhares, Alexandre

Abstract

The peer review system is a core tenet of scientific publishing, and has been studied throughout the years. Recent discussions on judgment and evaluation biases have highlighted the importance of priming effects on those processes. We have conducted two experiments with evaluation tasks (a scientific article evaluation, with professors and PhD students as participants, and a chocolate tasting, with undergraduates) in which they were exposed to a footnote acknowledging financial support from a fictional agency. In one condition, theagency’s name was associated with the African continent, while in another condition, it was associated with the European continent. There were statisticallysignificant differences in judgments on both tests, with individuals on the European condition giving better evaluations of the article and the chocolate, even thoughthe stimuli were subtle enough not to be remembered by 92.5 % of all participants. We also found evidence of a moderating effect of academic experience on thepriming process.Keywords: Peer review, priming, cognitive bias, judgment., O sistema de revisão por pares é um princípio básico da publicação científica, e tem sido estudado ao longo dos anos. As discussões recentes sobre viés nos juízos e as avaliações têm destacado a importância dos efeitos de priming nos processos. Temos realizado dois experimentos com tarefas de avaliação (uma avaliação de um artigo científico, com professores e estudantes de doutoramento como participantes, e uma degustação de chocolates, com estudantes universitários) na que estiveram expostos a uma nota de rodapé que reconhecia o apoio financeiro de uma agência fictícia. Em uma condição, o nome da agência associou-se com o continente africano, enquanto que em outra condição, foi associado com o continente europeu. Houve diferenças estatisticamente significativas em juízos em ambas as provas, com indivíduos na condição europeia dando melhores avaliações ao artigo e ao chocolate, apesar de que os estímulos foram o suficientemente sutis como para não serem lembrados pelo 92.5% de todos os participantes. Também encontramos evidência de um efeito moderador da experiência acadêmica no processo de priming.Palavras-chave: revisão por pares, priming, vieses cognitivos, juízos., El sistema de revisión por pares es un principio básico de la publicación científica, que ha sido estudiado a lo largo de los años. Las discusiones recientes sobre sesgos en los juicios y las evaluaciones han destacado la importancia de los efectos de priming en esos procesos. Hemos realizado dos experimentos con tareas de evaluación (una evaluación de un artículo científico, con profesores y estudiantes de doctorado como participantes, y una degustación de chocolates, con estudiantes universitarios) en las que estuvieron expuestos a una nota a pie de página que reconocía el apoyo financiero de una agencia ficticia. En una condición, el nombre de la agencia se asoció con el continente africano, mientras que en otra condición, fue asociado con el continente europeo. Hubo diferencias estadísticamente significativas en los juicios en ambas pruebas, tales que los individuos en la condición europea evaluaron mejor el artículo y el chocolate, a pesar de que los estímulos fueron lo suficientemente sutiles como para no ser recordados por el 92.5% de todos los participantes. También encontramos evidencia de un efecto moderador de la experiencia académica en el proceso de priming.Palabras clave: revisión por pares, priming, sesgos cognitivos, juicio.

Published
2019

74. Rotavirus P[4]G2 in a vaccinated population, Brazil

Author

Patel, Manish M., de Oliveira, Lucia Helena, Bispo, Ana Maria, Gentsch, Jon, Parashar, Umesh D., Linhares, Alexandre C., Velazquez, F. Raul, Gurgel, Ricardo Queiroz, Vieira, Sarah Cristina Fontes, Barros, Vanessa Cristiane Farias, Fontes, Paula Brandao, Salustino, Eduardo F., Nakagomi, Osamu, Nakagomi, Toyoko, Dove, Winifred, Cunliffe, Nigel A., and Cuevas, Luis E.

Abstract

To the Editor: Gurgel et al. provide an early examination of postmarketing surveillance data from Brazil, one of the first countries to implement routine childhood immunization with Rotarix vaccine (I). [...]

Published
2008

75. Prevalence and clinical features of respiratory syncytial virus in children hospitalized for community-acquired pneumonia in northern Brazil

Author

Lamarão Letícia, Ramos Francisco, Mello Wyller, Santos Mirleide, Barbagelata Luana, Justino Maria Cleonice, da Silva Alexandre, Quaresma AnaJudithPiresGarcia, da Silva Veronilce, Burbano Rommel, and Linhares Alexandre

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Childhood pneumonia and bronchiolitis is a leading cause of illness and death in young children worldwide with Respiratory Syncytial Virus (RSV) as the main viral cause. RSV has been associated with annual respiratory disease outbreaks and bacterial co-infection has also been reported. This study is the first RSV epidemiological study in young children hospitalized with community-acquired pneumonia (CAP) in Belém city, Pará (Northern Brazil). Methods With the objective of determining the prevalence of RSV infection and evaluating the patients’ clinical and epidemiological features, we conducted a prospective study across eight hospitals from November 2006 to October 2007. In this study, 1,050 nasopharyngeal aspirate samples were obtained from hospitalized children up to the age of three years with CAP, and tested for RSV antigen by direct immunofluorescence assay and by Reverse Transcription Polymerase Chain Reaction (RT-PCR) for RSV Group identification. Results RSV infection was detected in 243 (23.1%) children. The mean age of the RSV-positive group was lower than the RSV-negative group (12.1 months vs 15.5 months, pppppp Conclusion The present study highlights the relevance of RSV infection in hospitalized cases of CAP in our region; our findings warrant the conduct of further investigations which can help design strategies for controlling the disease.

Published
2012
Full Text
View/download PDF

76. Additional file 1: Web-appendix 1. of Efficacy, safety and effectiveness of licensed rotavirus vaccines: a systematic review and meta-analysis for Latin America and the Caribbean

Author

RaĂşl VelĂĄzquez, Linhares, Alexandre, MuĂąoz, Sergio, Seron, Pamela, Lorca, Pedro, DeAntonio, Rodrigo, and Ortega-Barria, Eduardo

Subjects
surgical procedures, operative, education, bacterial infections and mycoses, digestive system, digestive system diseases
Abstract

Search methods: detailed search strategy. Web-appendix 2. Criteria for trial eligibility. Web-appendix 3. Extraction sheet for trials assessing efficacy/safety and effectiveness/impact of rotavirus vaccine. Web-appendix 4. Extraction sheet for risk of bias assessment in trials evaluating efficacy/safety of rotavirus vaccine. Web-appendix 5. Selected studies for efficacy/safety evaluation of rotavirus vaccine. Web-appendix 6. Risk of bias graph. Web-appendix 7. Summary of the characteristics of studies included for assessing efficacy/safety of rotavirus vaccines. Web-appendix 8. Forest plot of meta-analysis for severe diarrhea of any cause. Web-appendix 9. Forest plot of meta-analysis for treatment-related mortality. Web-appendix 10. Forest plot of meta-analysis for treatment-related intussusception. Web-appendix 11. Common severe adverse events occurring in rotavirus immunized and placebo groups. Web-appendix 12. Forest plot of meta-analysis for treatment-related severe adverse events. Web-appendix 13. Identified studies for effectiveness evaluation of rotavirus vaccine. Web-appendix 14. Summary of the characteristics of studies included for evaluate effectivenes of rotavirus vaccine. Web-appendix 15. Summary of results of studies assessing effectiveness of rotavirus vaccine. (DOCX# 123 bytes)

Published
2017
Full Text
View/download PDF

77. Rotav?rus e alergia alimentar: uma breve revis?o sobre a doen?a e a import?ncia da vacina??o

Author

Levi, Guido, Ballalai, Isabella, Cunha, Juarez, Moura, Mayra, Levi, M?nica, Kfouri, Renato, vila, Adriana, Barreto, Ana Karolina, Fonseca, Eduardo Jorge, Sarinho, Emanuel, Cocco, Renata, Sato, Helena Keico, Giamberardino, Heloisa Lhle, Ribeiro, Jos? Geraldo, Petraglia, T?nia, Dourado, Solange, Sol?, Dirceu, Fernandes, F?tima Rodrigues, Linhares, Alexandre da Costa, and Justino, Maria Cleonice Aguiar

Subjects
Rotavirus / patogenicidade, Vacinas contra Rotavirus / administra??o & dosagem, Vacina??o / normas, Hipersensibilidade Alimentar / imunologia, Hipersensibilidade / imunologia
Abstract

Artigo produzido a partir da Nota T?cnica SBIm sobre o tema, dispon?vel em http://sbim.org.br/images/ files/nota-sbim-asbai-sbp-rotavirus08022017-v2.pdf. Sociedade Brasileira de Imuniza??es. S?o Paulo, SP, Brasil. Sociedade Brasileira de Imuniza??es. S?o Paulo, SP, Brasil. Sociedade Brasileira de Imuniza??es. S?o Paulo, SP, Brasil. Sociedade Brasileira de Imuniza??es. S?o Paulo, SP, Brasil. Sociedade Brasileira de Imuniza??es. S?o Paulo, SP, Brasil. Sociedade Brasileira de Imuniza??es. S?o Paulo, SP, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Sociedade Brasileira de Pediatria. Rio de Janeiro, RJ, Brasil. Associa??o Brasileira de Alergia e Imunologia. S?o Paulo, SP, Brasil. Associa??o Brasileira de Alergia e Imunologia. S?o Paulo, SP, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Os questionamentos sobre a utiliza??o da vacina rotav?rus s?o frequentes, tanto da parte de m?dicos quanto de pacientes. As principais d?vidas s?o sobre a efic?cia e seguran?a da vacina. Por?m, os casos de crian?as com quadros de alergia alimentar tamb?m despertam a aten??o, em especial quando h? diagn?stico ou suspeita de alergia ? prote?na do leite de vaca (APLV). Com o objetivo de esclarecer e orientar o profissional da Sa?de, especialmente o pediatra, para uma adequada prescri??o, os departamentos cient?ficos de imuniza??es e alergia das sociedades brasileiras de Imuniza??es (SBIm), de Alergia e Imunologia (Asbai) e de Pediatria (SBP), al?m do Instituto Evandro Chagas, produziram uma breve revis?o sobre a doen?a por rotav?rus, as vacinas hoje licenciadas e a import?ncia de sua utiliza??o, al?m de coment?rios sobre alergia alimentar.

Published
2017

80. Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases

Author

Vieira, Marcelo Adriano da Cunha e Silva, primary, Costa, Carlos Henrique Nery, additional, Linhares, Alexandre da Costa, additional, Borba, Amariles de Sousa, additional, Henriques, Daniele Freitas, additional, Silva, Eliana Vieira Pinto da, additional, Tavares, Fernando Neto, additional, Batista, Francisca Miriane de Araújo, additional, Guimarães, Herlon Clístenes Lima, additional, Martins, Lívia Carício, additional, Monteiro, Talita Antônia Furtado, additional, Cruz, Ana Cecília Ribeiro, additional, Azevedo, Raimunda do Socorro da Silva, additional, and Vasconcelos, Pedro Fernando da Costa, additional

Published
2018
Full Text
View/download PDF

81. Detection and genotyping of enteric viruses in hospitalized children with acute gastroenteritis in Belém, Brazil: Occurrence of adenovirus viremia by species F, types 40/41

Author

Portal, Thayara Morais, primary, Reymão, Tammy Kathlyn Amaral, additional, Quinderé Neto, Germano Alves, additional, Fiuza, Mercedes Kamila Da C, additional, Teixeira, Dielle Monteiro, additional, Lima, Ian Carlos Gomes, additional, Sousa Júnior, Edivaldo Costa, additional, Bandeira, Renato Da Silva, additional, De Deus, Danielle Rodrigues, additional, Justino, Maria Cleonice A, additional, Linhares, Alexandre Da Costa, additional, Silva, Luciana Damascena Da, additional, Resque, Hugo Reis, additional, and Gabbay, Yvone Benchimol, additional

Published
2018
Full Text
View/download PDF

82. Norovirus RNA in serum associated with increased fecal viral load in children: Detection, quantification and molecular analysis

Author

Reymão, Tammy Kathlyn Amaral, primary, Fumian, Tulio Machado, additional, Justino, Maria Cleonice Aguiar, additional, Hernandez, Juliana Merces, additional, Bandeira, Renato Silva, additional, Lucena, Maria Silvia Sousa, additional, Teixeira, Dielle Monteiro, additional, Farias, Fredison Pinheiro, additional, Silva, Luciana Damascena, additional, Linhares, Alexandre Costa, additional, and Gabbay, Yvone Benchimol, additional

Published
2018
Full Text
View/download PDF

84. Low genetic diversity of the Human T-cell Lymphotropic Virus (HTLV-1) in an endemic area of the Brazilian Amazon basin

Author

Nobre, Akim Felipe Santos, primary, Almeida, Danilo de Souza, additional, Ferreira, Louise Canto, additional, Ferreira, Deimy Lima, additional, Júnior, Edivaldo Costa Sousa, additional, Viana, Maria de Nazaré do Socorro de Almeida, additional, Silva, Ingrid Christiane, additional, Pinheiro, Bruna Teles, additional, Ferrari, Stephen Francis, additional, Linhares, Alexandre da Costa, additional, Ishikawa, Edna Aoba, additional, Sousa, Rita Catarina Medeiros, additional, and de Sousa, Maísa Silva, additional

Published
2018
Full Text
View/download PDF

86. Minimization of open orders: application of a re-distribution coordination policy.

Author

Linhares, Alexandre

Subjects
PRODUCTION planning, VERY large scale circuit integration, COMPUTATIONAL complexity, MACHINE theory, INDUSTRIAL management, PRODUCTION control, MATHEMATICAL optimization, PRODUCTION scheduling
Abstract

This work considers an NP-Hard scheduling problem that is fundamental to the production planning of flexible machines, to cutting pattern industries and also to the design of VLSI circuits. A new asynchronous collective search model is proposed, exploring the search space in a manner that concentrates effort onto those areas of higher perceived potential. This is done with the use of a coordination policy which enables the processes with greatest performance to act as 'attractors' to those processes trapped in areas of worse perceived potential. Numerical results are obtained for problems of realistic industrial size, and those results are compared to previously published optimal solutions. This comparison demonstrates the effectiveness of the method, as in 276 problems out of a set of 280 we are able to match previously reported optimal results. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

87. Vaccines against rotavirus and human papillomavirus (HPV)

Author

LINHARES, Alexandre Costa and VILLA, Luisa Lina

Subjects
Rotavírus, Vacina, HPV, Verrugas genitais, Human papillomavirus, Câncer do colo do útero, Gastroenterite, Cervical cancer, Papilomavírus humano, Vaccine, Genital warts
Abstract

OBJETIVOS: Sintetizar as estratégias para a obtenção de uma vacina contra rotavírus e papilomavírus humano (HPV), enfatizando-se o estágio atual das investigações quanto à segurança, reatogenicidade, imunogenicidade e eficácia. FONTE DOS DADOS: Os artigos publicados de 1996 a 2006, particularmente ao longo dos últimos 5 anos, representaram a fonte primária (base de dados: MEDLINE, PubMed, NIH, EUA), conferindo-se destaque aos recentes estudos envolvendo uma vacina contendo rotavírus atenuado de origem humana e dois tipos de vacinas para HPV testadas em humanos: as profiláticas e as terapêuticas. SÍNTESE DOS DADOS: Em relação às vacinas contra rotavírus, o contexto de estratégias compreendeu desde as preparações jennerianas até o advento da vacina com rotavírus atenuado de origem humana. Duas vacinas despontam como eficazes e seguras: uma, pentavalente, envolvendo vírus de bovinos e do homem; outra, de rotavírus atenuado oriundo da espécie humana, sendo que esta é avaliada em mais de 70.000 crianças no mundo. As vacinas contra HPV profiláticas visam impedir a infecção por esses vírus, enquanto que as vacinas terapêuticas pretendem tratar o indivíduo já infectado ou até o portador de uma lesão causada por HPV. As pesquisas com vacinas profiláticas começaram há alguns anos nos EUA e, hoje, aproximadamente 25.000 mulheres, em vários países, participam de estudos sobre essa vacina, que até o momento tem se mostrado segura, bem tolerada, altamente imunogênica e eficaz contra os tipos de HPV que causam as verrugas genitais e 70% dos casos de câncer do colo do útero. CONCLUSÕES:Uma vacina eficaz e segura contra rotavírus resultará em impacto significativo quanto à doença grave por esse enteropatógeno. Um programa global de imunizações que consiga atingir 60 a 80% das crianças durante os próximos 10 anos pode reduzir em pelo menos 50% as hospitalizações e a mortalidade por rotavírus. Antecipa-se que a implementação de vacinas de elevada eficácia na prevenção de tumores benignos e malignos causados por alguns tipos de HPV leve a uma queda acentuada das taxas desses tumores, os quais afetam milhões de pessoas em todo o mundo. Objective: To briefly review strategies aimed at the development of rotavirus and HPV vaccines, with emphasis on the current status of studies assessing the safety, reactogenicity, immunogenicity and efficacy of recently developed vaccines. Sources of data: This review focuses on articles published from 1996 to 2006, mainly those from the last five years, with special emphasis on data obtained from recently completed studies involving a new live attenuated human rotavirus vaccine and a virus-like particle (HPV) vaccine. Summary of the findings: Strategies for developing rotavirus vaccines ranged from Jennerian approaches to the new human-derived rotavirus vaccine. Currently, two rotavirus vaccines are recognized as both efficacious and safe: a pentavalent human-bovine reassortant vaccine and a vaccine derived from an attenuated rotavirus of human origin. The second of these has been evaluated in more than 70,000 infants all over the world. Prophylactic vaccines against HPV have been tested in more than 25,000 young individuals around the world. Results from phase II and III clinical studies indicate that such vaccines against the most common types of HPV, those linked to both genital warts and 70% of cervical cancers, are safe and highly efficacious. Conclusions: A future rotavirus immunization program covering 60 to 80% of infants worldwide is likely to reduce by at least 50% the number of rotavirus-associated hospitalizations and deaths. It is also reasonable to expect that implementation of HPV prophylactic vaccines will reduce the burden of the HPV-related diseases that presently impact millions of people around the world. LINHARES, A.C. Universidade Federal do Pará, Instituto de Ciências da Saúde (FAMED/ ICS)

Published
2016

88. High prevalence of G12P[8] rotavirus strains in Rio Branco, Acre, Western Amazon, in the post-rotavirus vaccine introduction period

Author

Neves, Mayara A. O, Pinheiro, Helder H. C, Silva, Rita do Socorro Uch?a da, Linhares, Alexandre da Costa, Silva, Luciana Damascena da, Gabbay, Yvone Benchimol, Silva, M?nica Cristina de Moraes, Loureiro, Edvaldo Carlos Brito, Soares, Luana da Silva, and Mascarenhas, Joana D'Arc Pereira

Subjects
Gen?tipo, Rotavirus / gen?tica, Infec??es por Rotavirus / virologia, Rea??o em Cadeia da Polimerase Via Transcriptase Reversa / m?todos, Infec??es por Rotavirus / epidemiologia, Ensaio de Imunoadsor??o Enzim?tica / m?todos, Diarreia Infantil, Rotavirus / classifica??o
Abstract

University of State of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. Federal University of Par?, Par?. Center for Tropical Medicine. Bel?m, PA, Brazil. Municipality Secretary of Health. Rio Branco, Acre, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. The present study aimed to provide a molecular characterization of circulating rotavirus (RVA) strains in Rio Branco, Acre, in the post-rotavirus vaccination period, particularly with regard to the emerging, increasingly prevalent G12P[8] genotype. A total of 488 fecal specimens from diarrheic and non-diarrheic children were obtained between January and December 2012. RVA detection was initially performed using enzyme-linked immunosorbent assay (ELISA) method, followed by reverse-transcription polymerase chain reaction (RT-PCR) using specific primers. RVA was detected in 18.3 per cent (44/241) of the children with acute diarrhea and in 1.2 per cent (3/247) of the non-diarrheic children (P 0.001), with overall RVA-positivity of 9.6 per cent (47/488). The most common genotype was G2P[4] with 43.2 per cent (19/44) of the diarrheic cases, followed by G12P[8] (27.3 per cent, 12/44), G3P[6] (18.2 per cent, 8/44), G3P[8] (4.5 per cent, 2/44), and G12P[6] (2.3 per cent, 1/44). G12 samples belonged to lineage III and were from children aged 4?52 months. All of these children had acute diarrhea associated with fever (83.3 per cent, 10/12) and vomiting (66.7 per cent, 8/12). Most of the cases occurred in August (58.3 per cent, 7/12), 75 per cent (9/12) of which having received the full vaccination scheme with Rotarix?. For the first time G12 was reported at relative high prevalence in Brazil. Our findings warrant further monitoring studies on the molecular characterization of circulating RVA strains after rotavirus vaccine introduction in Brazil and elsewhere, since the occurrence of either unusual our emerging genotypes may pose a challenge to vaccination strategies.

Published
2016

89. Vacina??o contra rotav?rus: achados recentes, impacto em sa?de p?blica, perspectivas e desafios uma d?cada depois

Author

Linhares, Alexandre da Costa and Justino, Maria Cleonice Aguiar

Subjects
Vacina??o / m?todos, Vacinas contra Rotavirus / administra??o & dosagem, Programas de Imuniza??o / m?todos, Cobertura Vacinal
Abstract

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Published
2016

90. Phylogenetic analysis of human group C rotavirus in hospitalized children with gastroenteritis in Bel?m, Brazil

Author

Lobo, Patr?cia dos Santos, Guerra, Sylvia de F?tima dos Santos, Siqueira, Jones Anderson Monteiro, Soares, Luana da Silva, Gabbay, Yvone Benchimol, Linhares, Alexandre da Costa, and Mascarenhas, Joana D'Arc Pereira

Subjects
Gastroenterite / epidemiologia, Gen?tipo, Rotavirus / gen?tica, Infec??es por Rotavirus / virologia, viruses, Rea??o em Cadeia da Polimerase Via Transcriptase Reversa / m?todos, virus diseases, Infec??es por Rotavirus / epidemiologia, Crian?a Hospitalizada, Rotavirus / classifica??o, Regi?o Amaz?nica (BR), Gastroenterite / virologia
Abstract

Federal University of Par?. Tropical Medicine Center. Bel?m, PA, Brasil. Federal University of Par?. Tropical Medicine Center. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Group C rotavirus (RVC) is potentially an important pathogen associated with acute gastroenteritis (AG), especially in outbreaks. This study aims to detect and molecularly characterize RVC in hospitalized children with AG in Bel?m, Brazil. From May 2008 to April 2011, 279 stools were subjected to reverse-transcription polymerase chain reaction targeting VP7, VP6, VP4, and NSP4 genes. RVC positivity rate was 2.1 per cent (6/279) and phylogenetic analysis of positive samples yields genotype G4-P[2]-I2-E2. No evidence of zoonotic transmission and VP7 gene demonstrated close relationship with Asian strains. RVC surveillance is worth to expand information on evolutionary and epidemiological features of this virus.

Published
2016

91. Detection of a novel equine-like G3 rotavirus associated with acute gastroenteritis in Brazil

Author

Guerra, Sylvia F?tima Santos, Soares, Luana Silva, Lobo, Patricia Santos, Penha Junior, Edvaldo Tavares, Sousa Junior, Edivaldo Costa, Bezerra, Delana Andreza Melo, Vaz, L?via Rodrigues, Linhares, Alexandre da Costa, and Mascarenhas, Joana D'Arc Pereira

Subjects
Varia??o Gen?tica, Gen?tipo, Filogenia, Rotavirus / gen?tica, RNA Viral / gen?tica, Rotavirus / isolamento & purifica??o, virus diseases, Rea??o em Cadeia da Polimerase / m?todos, Ecossistema Amaz?nico, Gastroenterite / virologia
Abstract

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Genotype G3P[8] of rotavirus A (RVA) is detected worldwide, usually associated with Wa-like constellation and exhibiting a long RNA migration pattern. More recently, a novel inter-genogroup, G3P[8] reassortant variant with a short electropherotype, has emerged in Asia, Oceania and Europe, denoting an overall potential of unusual rotavirus strains. During a RVA surveillance in Brazil, G3P[8] strains were found displaying a short electropherotype pattern, which had not been detected before in this region. This study aims to characterize the complete genome of 10 G3P[8] strains detected in the northern region of Brazil. All G3P[8] samples were subjected to partial sequencing, and the whole-genome phylogenetic analysis demonstrated that all strains possessed I2-R2-C2-M2-A2-N1-T2-E2-H2 genotype background, representing reassortants with an equine-like G3 VP7 and amino acid changes in VP4 and VP7 antigenic regions as compared to vaccine strains. Phylogenetic analysis demonstrated high nucleotide identity in almost all RNA segments of G3P[8] DS-1 samples detected in Asia, Oceania and Europe as well as G3P[4] strains in Japan. This study reports a novel, equine-like G3P[8] strain circulating in Brazil and isolated from children hospitalized for severe gastroenteritis, and highlights the complex dynamics of RVA molecular epidemiology. Our findings point to a novel RVA strain emerging in this region, and studies should be done to detect whether this may represent a challenge to current vaccine strategies.

Published
2016

92. Detection and genotyping of human adenovirus and sapovirus in children with acute gastroenteritis in Belém, Pará, between 1990 and 1992: first detection of GI.7 and GV.2 sapoviruses in Brazil

Author

Costa, Larissa Cristina Prado das Neves, primary, Siqueira, Jones Anderson Monteiro, additional, Portal, Thayara Morais, additional, Sousa Júnior, Edivaldo Costa, additional, Linhares, Alexandre da Costa, additional, Gabbay, Yvone Benchimol, additional, and Resque, Hugo Reis, additional

Published
2017
Full Text
View/download PDF

94. Detection and genetic characterization of the emergent GII.17_2014 norovirus genotype among children with gastroenteritis from Northern Brazil

Author

Silva, Luciana Damascena da, primary, Bandeira, Renato da Silva, additional, Junior, Edivaldo Costa Sousa, additional, Lima, Ian Carlos Gomes de, additional, da Penha Júnior, Edvaldo Tavares, additional, Teixeira, Dielle Monteiro, additional, Siqueira, Jones Anderson Monteiro, additional, Resque, Hugo Reis, additional, de Abreu Campos, Erika Maria Nogueira, additional, Justino, Maria Cleonice Aguiar, additional, Linhares, Alexandre Costa, additional, and Gabbay, Yvone Benchimol, additional

Published
2017
Full Text
View/download PDF

96. Detection of a novel equine-like G3 rotavirus associated with acute gastroenteritis in Brazil

Author

Guerra, Sylvia Fátima Santos, primary, Soares, Luana Silva, additional, Lobo, Patrícia Santos, additional, Penha Júnior, Edvaldo Tavares, additional, Sousa Júnior, Edivaldo Costa, additional, Bezerra, Delana Andreza Melo, additional, Vaz, Lívia Rodrigues, additional, Linhares, Alexandre Costa, additional, and Mascarenhas, Joana D’Arc Pereira, additional

Published
2016
Full Text
View/download PDF

97. Analysis of a genotype G3P[9] rotavirus a strain that shows evidence of multiple reassortment events between animal and human rotaviruses

Author

Bezerra, Delana A.M., primary, Guerra, Sylvia F.S., additional, Serra, Ana C.S., additional, Fecury, Priscylla C.M.S., additional, Bandeira, Renato S., additional, Penha, Edvaldo T., additional, Lobo, Patrícia S., additional, Sousa, Edivaldo C., additional, Linhares, Alexandre C., additional, Soares, Luana S., additional, and Mascarenhas, Joana D.P., additional

Published
2016
Full Text
View/download PDF

98. Detecção de antígenos de rotavírus no soro de crianças hospitalizadas por gastroenterite aguda em Belém, Estado do Pará, Brasil

Author

Justino, Maria Cleonice Aguiar, primary, Campos, Erika Maria Nogueira de Abreu, additional, Mascarenhas, Joana D'Arc Pereira, additional, Soares, Luana da Silva, additional, Soares, Sissa Gabrielle Ribeiro, additional, Soares, Tassia Salgado, additional, Pavão, Manoel Jaime Castro, additional, Bezerra, Orvácio Melo, additional, Maciel, Tássio Sampaio, additional, Farias, Fredison Pinheiro, additional, and Linhares, Alexandre da Costa, additional

Published
2016
Full Text
View/download PDF

99. Rotavirus strain surveillance for three years following the introduction of rotavirus vaccine into Bel?m, Brazil

Author

Guerra, Sylvia de F?tima dos Santos, Linhares, Alexandre da Costa, Mascarenhas, Joana D'Arc Pereira, Oliveira, Alessilva, Justino, Maria Cleonice Aguiar, Soares, Luana da Silva, M?ller, Elza Caroline, Brasil, Patr?cia, Tuboi, Suely, Ortega-Barria, Eduardo, and Colindres, R?mulo

Subjects
Vacina??o / utiliza??o, Rotavirus, Gen?tipo, Gastroenterite, Rea??o em Cadeia da Polimerase Via Transcriptase Reversa / m?todos, virus diseases, Ensaio de Imunoadsor??o Enzim?tica / m?todos, Bel?m (PA)
Abstract

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Oswaldo Cruz Foundation. Clinical Research Institute Evandro Chagas. Rio de Janeiro, RJ, Brasil GlaxoSmithKline. Rio de Janeiro, RJ, Brazil. GlaxoSmithKline. Panama, Panama. GlaxoSmithKline. Rio de Janeiro, RJ, Brazil. The monovalent human rotavirus (RV) vaccine, RIX4414 (Rotarix , GlaxoSmithKline Biologicals) was introduced into Brazil's Expanded Program on Immunization in March 2006. One year after vaccine introduction, the G2P[4] strain was found to be predominant, with an apparent extinction of many non-G2 strains. This study investigated the diversity of circulating strains in the three years following RIX4414 introduction. Between May 2008 and May 2011, stool samples were collected from children aged =12 weeks who were hospitalized for severe lab confirmed RV-gastroenteritis (=3 liquid or semi-liquid motions over a 24-h period for >14 days, requiring =1 overnight hospital stay and intravenous rehydration therapy) in Bel?m, Brazil. RV-gastroenteritis was detected by ELISA and the G- and P-types were determined by RT-PCR assays. During the first year of surveillance nucleotide sequencing was used for typing those samples not previously typed by RT-PCR. A total of 1,726 of 10,030 severe gastroentertis hospitalizations (17.2 per cent) were due to severe RVGE. G2P[4] was detected in 57.2 per cent of circulating strains over the whole study period, however it predominated during the first 20 months from May 2008 to January 2009. G1P[8] increased in the last part of the study period from May 2010 to May 2011 and represented 36.6 per cent (112/306) of the circulating strains. G2P[4] was the predominant RV strain circulating during the first 20 months of the study, followed by G1P[8]. These findings probably reflect a natural fluctuation in RV strains over time, rather than a vaccine-induced selective pressure.

Published
2015

100. Detection and genotyping of enteric viruses in hospitalized children with acute gastroenteritis in Belém, Brazil: Occurrence of adenovirus viremia by species F, types 40/41.

Author

Portal, Thayara Morais, Reymão, Tammy Kathlyn Amaral, Quinderé Neto, Germano Alves, Fiuza, Mercedes Kamila Da C, Teixeira, Dielle Monteiro, Lima, Ian Carlos Gomes, Sousa Júnior, Edivaldo Costa, Bandeira, Renato Da Silva, Deus, Danielle Rodrigues, Justino, Maria Cleonice A, Linhares, Alexandre Da Costa, Silva, Luciana Damascena Da, Resque, Hugo Reis, and Gabbay, Yvone Benchimol

Abstract

Enteric adenovirus (AdV), sapovirus (SaV), and human astrovirus (HAstV) are important pathogens involved in the gastroenteritis etiology. In this study, a total of 219 fecal samples and sera were collected from children hospitalized for acute gastroenteritis (AGE) in two large pediatric hospitals in Belém, from March 2012 to April 2015. The samples were analyzed by polymerase chain reaction (PCR) for AdV and HAstV (astrovirus) detection, and Nested‐PCR and qPCR for SaV detection. AdV was detected in 50.2% (110/219) of the cases, with 42.7% (47/110) being sequenced and classified as: species F (63.9% – 30/47), A (4.2% – 2/47), B (6.4% – 3/47), C (17.1% – 8/47), D (4.2% – 2/47), and E (4.2% – 2/47). Of the 110 AdV‐positive feces samples, 80 paired sera presented sufficient amounts and were also tested for this virus, of which 51 (63.7%) showed positive results and 26 (70.3%) pairs (feces plus sera) presented concordant results after sequencing being classified as: species F (21/26; 80.8%), A (1/26; 3.8%), B (1/26; 3.8%), and C (3/26; 11.5%). Overall, HAstV rate in the feces samples was 1.8% (4/219), including both HAstV‐1a (2/4; 50%) and HAstV‐2c (2/4; 50%). SaV was detected in 4.6% (10/219) of the fecal samples, out of which 50% (5/10) of the positive samples were characterized into the genogroups GI.1 (1), GI.2 (2), and GII.4 (2). These findings highlighted the important contributions of AdV, HAstV, and SaV in the enteric virus spectrum in our region and showed the high genetic diversity of AdV. In addition, it demonstrated for the first time in Brazil, the circulation of AdV in the serum of hospitalized children with AGE. 1.Detection of enteric adenoviruses in samples of blood and feces of children.2.First detection of adenovirus viremia in blood of children hospitalized for gastroenteritis.3.Detection of adenovirus types F40/41 in blood and fecal samples.4.Genetic diversity of adenovirus in serum and fecal samples. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results