Search

Your search keyword '"Lin-Wei Yu"' showing total 1,024 results
Start Over Author "Lin-Wei Yu"
1,024 results on '"Lin-Wei Yu"'

52. A Propensity Score–Matched Analysis of the Impact of Carcinoma In Situ on the Clinical Outcomes in Patients with Upper Tract Urothelial Carcinomas—A Nationwide Multi-Institutional Cohort Study

Author

Wong, Shin Mei, primary, Ke, Hung-Lung, additional, Li, Wei-Ming, additional, Chang, Chao-Hsiang, additional, Huang, Chi-Ping, additional, Wu, Shu-Yu, additional, Tsai, Yao-Zhou, additional, Huang, Steven K., additional, Tsing, Wen-Hsin, additional, Chen, I-Hsuan Alan, additional, Lin, Jen-Tai, additional, Tsai, Chung-You, additional, Cheng, Pai-Yu, additional, Jiang, Yuan-Hong, additional, Lee, Yu-Khun, additional, Chiang, Bing-Juin, additional, Chen, Yung-Tai, additional, Chuech, Leonard S., additional, Hsueh, Thomas Y., additional, Lin, Wei Yu, additional, Wu, Chia-Chang, additional, Tseng, Jen-Shu, additional, Chen, Pi-Che, additional, Huang, Chao-Yuan, additional, and Hong, Jian-Hua, additional

Published
2024
Full Text
View/download PDF

53. Molecular Recognition Enables Nanosubstrate-Mediated Delivery of Gene-Encapsulated Nanoparticles with High Efficiency

Author

Peng, Jinliang, Garcia, Mitch André, Choi, Jin-sil, Zhao, Libo, Chen, Kuan-Ju, Bernstein, James R, Peyda, Parham, Hsiao, Yu-Sheng, Liu, Katherine W, Lin, Wei-Yu, Pyle, April D, Wang, Hao, Hou, Shuang, and Tseng, Hsian-Rong

Subjects
Dementia, Neurosciences, Biotechnology, Genetics, Gene Therapy, Bioengineering, Brain Disorders, Nanotechnology, Acquired Cognitive Impairment, Generic health relevance, Amino Acid Motifs, Animals, Female, Gene Transfer Techniques, Genetic Vectors, HEK293 Cells, HeLa Cells, Humans, Jurkat Cells, Light, MCF-7 Cells, Mice, Mice, Inbred BALB C, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Microscopy, Fluorescence, NIH 3T3 Cells, Nanoparticles, Particle Size, Scattering, Radiation, beta-Cyclodextrins, nanosubstrate, self-assembled supramolecular nanoparticles, molecular motif, molecular recognition, gene delivery, Hela Cells, Nanoscience & Nanotechnology
Abstract

Substrate-mediated gene delivery is a promising method due to its unique ability to preconcentrate exogenous genes onto designated substrates. However, many challenges remain to enable continuous and multiround delivery of the gene using the same substrates without depositing payloads and immobilizing cells in each round of delivery. Herein we introduce a gene delivery system, nanosubstrate-mediated delivery (NSMD) platform, based on two functional components with nanoscale features, including (1) DNA⊂SNPs, supramolecular nanoparticle (SNP) vectors for gene encapsulation, and (2) Ad-SiNWS, adamantane (Ad)-grafted silicon nanowire substrates. The multivalent molecular recognition between the Ad motifs on Ad-SiNWS and the β-cyclodextrin (CD) motifs on DNA⊂SNPs leads to dynamic assembly and local enrichment of DNA⊂SNPs from the surrounding medium onto Ad-SiNWS. Subsequently, once cells settled on the substrate, DNA⊂SNPs enriched on Ad-SiNWS were introduced through the cell membranes by intimate contact with individual nanowires on Ad-SiNWS, resulting in a highly efficient delivery of exogenous genes. Most importantly, sequential delivery of multiple batches of exogenous genes on the same batch cells settled on Ad-SiNWS was realized by sequential additions of the corresponding DNA⊂SNPs with equivalent efficiency. Moreover, using the NSMD platform in vivo, cells recruited on subcutaneously transplanted Ad-SiNWS were also efficiently transfected with exogenous genes loaded into SNPs, validating the in vivo feasibility of this system. We believe that this nanosubstrate-mediated delivery platform will provide a superior system for in vitro and in vivo gene delivery and can be further used for the encapsulation and delivery of other biomolecules.

Published
2014

60. Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

Author

Tachmazidou, Ioanna, Süveges, Dániel, Min, Josine L., Ritchie, Graham R.S., Steinberg, Julia, Walter, Klaudia, Iotchkova, Valentina, Schwartzentruber, Jeremy, Huang, Jie, Memari, Yasin, McCarthy, Shane, Crawford, Andrew A., Bombieri, Cristina, Cocca, Massimiliano, Farmaki, Aliki-Eleni, Gaunt, Tom R., Jousilahti, Pekka, Kooijman, Marjolein N., Lehne, Benjamin, Malerba, Giovanni, Männistö, Satu, Matchan, Angela, Medina-Gomez, Carolina, Metrustry, Sarah J., Nag, Abhishek, Ntalla, Ioanna, Paternoster, Lavinia, Rayner, Nigel W., Sala, Cinzia, Scott, William R., Shihab, Hashem A., Southam, Lorraine, St Pourcain, Beate, Traglia, Michela, Trajanoska, Katerina, Zaza, Gialuigi, Zhang, Weihua, Artigas, María S., Bansal, Narinder, Benn, Marianne, Chen, Zhongsheng, Danecek, Petr, Lin, Wei-Yu, Locke, Adam, Luan, Jian’an, Manning, Alisa K., Mulas, Antonella, Sidore, Carlo, Tybjaerg-Hansen, Anne, Varbo, Anette, Zoledziewska, Magdalena, Finan, Chris, Hatzikotoulas, Konstantinos, Hendricks, Audrey E., Kemp, John P., Moayyeri, Alireza, Panoutsopoulou, Kalliope, Szpak, Michal, Wilson, Scott G., Boehnke, Michael, Cucca, Francesco, Di Angelantonio, Emanuele, Langenberg, Claudia, Lindgren, Cecilia, McCarthy, Mark I., Morris, Andrew P., Nordestgaard, Børge G., Scott, Robert A., Tobin, Martin D., Wareham, Nicholas J., Burton, Paul, Chambers, John C., Smith, George Davey, Dedoussis, George, Felix, Janine F., Franco, Oscar H., Gambaro, Giovanni, Gasparini, Paolo, Hammond, Christopher J., Hofman, Albert, Jaddoe, Vincent W.V., Kleber, Marcus, Kooner, Jaspal S., Perola, Markus, Relton, Caroline, Ring, Susan M., Rivadeneira, Fernando, Salomaa, Veikko, Spector, Timothy D., Stegle, Oliver, Toniolo, Daniela, Uitterlinden, André G., Barroso, Inês, Greenwood, Celia M.T., Perry, John R.B., Walker, Brian R., Butterworth, Adam S., Xue, Yali, Durbin, Richard, Small, Kerrin S., Soranzo, Nicole, Timpson, Nicholas J., and Zeggini, Eleftheria

Published
2017
Full Text
View/download PDF

61. Base-promoted triple cleavage of CCl2Br: a direct one-pot synthesis of unsymmetrical oxalamide derivatives.

Author

Jayaram, Alageswaran, Seenivasan, Vijay Thavasianandam, Govindan, Karthick, Liu, Yu-Ming, Chen, Nian-Qi, Yeh, Ting-Wei, Venkatachalam, Gokulakannan, Li, Chien-Hung, Leung, Tsz-Fai, and Lin, Wei-Yu

Subjects
BATCH processing, WATER use, BROMINATION, AMIDES
Abstract

We present a novel, eco-friendly and one-pot approach for synthesizing unsymmetrical oxalamides with the aid of dichloroacetamide and amine/amides in the presence of CBr4 in a basic medium. The use of water as a potent supplement for the oxygen atom source and the detailed mechanism have been disclosed. Moreover, the protocol involves triple cleavage of CCl2Br and the formation of new C–O/C–N bonds, with the advantage of achieving selective bromination using CBr4 with good to excellent yield under mild conditions. The method also demonstrates promise for industrial use, as proven by its effective implementation in gram-scale synthesis conducted in a batch process, along with its utilization in a continuous-flow system. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

64. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Author

Evangelou, Evangelos, Warren, Helen R., Mosen-Ansorena, David, Mifsud, Borbala, Pazoki, Raha, Gao, He, Ntritsos, Georgios, Dimou, Niki, Cabrera, Claudia P., Karaman, Ibrahim, Ng, Fu Liang, Evangelou, Marina, Witkowska, Katarzyna, Tzanis, Evan, Hellwege, Jacklyn N., Giri, Ayush, Velez Edwards, Digna R., Sun, Yan V., Cho, Kelly, Gaziano, J. Michael, Wilson, Peter W. F., Tsao, Philip S., Kovesdy, Csaba P., Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Debette, Stéphanie, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G., Jackson, Anne U., Li-Gao, Ruifang, Lin, Wei-Yu, Luan, Jian’an, Mangino, Massimo, Oldmeadow, Christopher, Prins, Bram Peter, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M., Zhao, Jing-Hua, Amouyel, Philippe, Connell, John, de Mutsert, Renée, Doney, Alex S. F., Farrall, Martin, Menni, Cristina, Morris, Andrew D., Noordam, Raymond, Paré, Guillaume, Poulter, Neil R., Shields, Denis C., Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Amin, Najaf, Arking, Dan E., Ayers, Kristin L., Barbieri, Caterina M., Batini, Chiara, Bis, Joshua C., Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I., Bottinger, Erwin P., Braund, Peter S., Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C., Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J., Davies, Gail, de Borst, Martin H., de Geus, Eco J., Deary, Ian J., Deelen, Joris, Del Greco M., Fabiola, Demirkale, Cumhur Yusuf, Dörr, Marcus, Ehret, Georg B., Elosua, Roberto, Enroth, Stefan, Erzurumluoglu, A. Mesut, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H., Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J., Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Harris, Sarah E., Hartman, Catharina A., Havulinna, Aki S., Hicks, Andrew A., Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E., Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo-Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D., Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D., Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S., Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J., Lehne, Benjamin, Lehtimäki, Terho, Liewald, David C. M., Lin, Li, Lind, Lars, Lindgren, Cecilia M., Liu, YongMei, Loos, Ruth J. F., Lopez, Lorna M., Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P., Morrison, Alanna C., Munson, Peter J., Nalls, Mike A., Nandakumar, Priyanka, Nelson, Christopher P., Niiranen, Teemu, Nolte, Ilja M., Nutile, Teresa, Oldehinkel, Albertine J., Oostra, Ben A., O’Reilly, Paul F., Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, Penninx, Brenda W. J. H., Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P., Nguyen, Quang Tri, Raitakari, Olli T., Ren, Meixia, Rettig, Rainer, Rice, Kenneth, Ridker, Paul M., Ried, Janina S., Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M., Rotter, Jerome I., Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F., Salomaa, Veikko, Samani, Nilesh J., Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V., Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M., Stott, David J., Strachan, David P., Strawbridge, Rona J., Sundström, Johan, Swertz, Morris A., Taylor, Kent D., Teumer, Alexander, Tobin, Martin D., Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G., Vaez, Ahmad, van der Most, Peter J., van Duijn, Cornelia M., Vergnaud, Anne-Claire, Verwoert, Germaine C., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H., Willemsen, Gonneke, Wilson, James F., Wright, Alan F., Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R., Butterworth, Adam S., Chasman, Daniel I., Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna M. M., Laakso, Markku, Lakatta, Edward G., Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O., Palmer, Colin N. A., Risch, Lorenz, Scott, Robert A., Scott, Rodney J., Sever, Peter, Spector, Tim D., van der Harst, Pim, Wareham, Nicholas J., Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B., Newton-Cheh, Christopher, Brown, Morris J., Metspalu, Andres, Hung, Adriana M., O’Donnell, Christopher J., Edwards, Todd L., Psaty, Bruce M., Tzoulaki, Ioanna, Barnes, Michael R., Wain, Louise V., Elliott, Paul, Caulfield, Mark J., and the Million Veteran Program

Published
2018
Full Text
View/download PDF

69. Biallelic TET2 mutations confer sensitivity to 5'-azacitidine in acute myeloid leukemia.

Author

Stölzel, Friedrich, Stölzel, Friedrich, Fordham, Sarah E, Nandana, Devi, Lin, Wei-Yu, Blair, Helen, Elstob, Claire, Bell, Hayden L, Mohr, Brigitte, Ruhnke, Leo, Kunadt, Desiree, Dill, Claudia, Allsop, Daniel, Piddock, Rachel, Soura, Emmanouela-Niki, Park, Catherine, Fadly, Mohd, Rahman, Thahira, Alharbi, Abrar, Wobus, Manja, Altmann, Heidi, Röllig, Christoph, Wagenführ, Lisa, Jones, Gail L, Menne, Tobias, Jackson, Graham H, Marr, Helen J, Fitzgibbon, Jude, Onel, Kenan, Meggendorfer, Manja, Robinson, Amber, Bziuk, Zuzanna, Bowes, Emily, Heidenreich, Olaf, Haferlach, Torsten, Villar, Sara, Ariceta, Beñat, Diaz, Rosa Ayala, Altschuler, Steven J, Wu, Lani F, Prosper, Felipe, Montesinos, Pau, Martinez-Lopez, Joaquin, Bornhäuser, Martin, Allan, James M, Stölzel, Friedrich, Stölzel, Friedrich, Fordham, Sarah E, Nandana, Devi, Lin, Wei-Yu, Blair, Helen, Elstob, Claire, Bell, Hayden L, Mohr, Brigitte, Ruhnke, Leo, Kunadt, Desiree, Dill, Claudia, Allsop, Daniel, Piddock, Rachel, Soura, Emmanouela-Niki, Park, Catherine, Fadly, Mohd, Rahman, Thahira, Alharbi, Abrar, Wobus, Manja, Altmann, Heidi, Röllig, Christoph, Wagenführ, Lisa, Jones, Gail L, Menne, Tobias, Jackson, Graham H, Marr, Helen J, Fitzgibbon, Jude, Onel, Kenan, Meggendorfer, Manja, Robinson, Amber, Bziuk, Zuzanna, Bowes, Emily, Heidenreich, Olaf, Haferlach, Torsten, Villar, Sara, Ariceta, Beñat, Diaz, Rosa Ayala, Altschuler, Steven J, Wu, Lani F, Prosper, Felipe, Montesinos, Pau, Martinez-Lopez, Joaquin, Bornhäuser, Martin, and Allan, James M

Abstract

Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient with acute myeloid leukemia (AML) that was chemoresistant to anthracycline and cytarabine but acutely sensitive to 5'-azacitidine (5'-Aza) hypomethylating monotherapy, resulting in long-term morphological remission. Given the role of TET2 as a regulator of genomic methylation, we hypothesized that mutant TET2 allele dosage affects response to 5'-Aza. Using an isogenic cell model system and an orthotopic mouse xenograft, we demonstrate that biallelic TET2 mutations confer sensitivity to 5'-Aza compared with cells with monoallelic mutations. Our data argue in favor of using hypomethylating agents for chemoresistant disease or as first-line therapy in patients with biallelic TET2-mutated AML and demonstrate the importance of considering mutant allele dosage in the implementation of precision medicine for patients with cancer.

Published
2023

70. PhNCO-enabled synthesis of secondary amides from N-(2-aminophenyl)benzamides.

Author

Govindan, Karthick, Chen, Nian-Qi, Jayaram, Alageswaran, and Lin, Wei-Yu

Subjects
BENZAMIDE, AMIDES
Abstract

We have successfully developed an efficient method for synthesizing secondary amides utilizing easily accessible N-(2-aminophenyl)benzamide and phenyl isocyanate. Notably, the leaving group can be easily recuperated as a carbonylated N-heterocycle, which holds notable relevance in pharmaceutical applications. The crux of this strategy involves a sequential nucleophilic/intramolecular addition process of phenyl isocyanate, followed by transamidation. Moreover, the protocol features atom-economy, practicality, a one-pot two-step reaction, and facile preparation of substrates. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

73. Data from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus

Author

Camp, Nicola J., primary, Lin, Wei-Yu, primary, Bigelow, Alex, primary, Burghel, George J., primary, Mosbruger, Timothy L., primary, Parry, Marina A., primary, Waller, Rosalie G., primary, Rigas, Sushilaben H., primary, Tai, Pei-Yi, primary, Berrett, Kristofer, primary, Rajamanickam, Venkatesh, primary, Cosby, Rachel, primary, Brock, Ian W., primary, Jones, Brandt, primary, Connley, Dan, primary, Sargent, Robert, primary, Wang, Guoying, primary, Factor, Rachel E., primary, Bernard, Philip S., primary, Cannon-Albright, Lisa, primary, Knight, Stacey, primary, Abo, Ryan, primary, Werner, Theresa L., primary, Reed, Malcolm W.R., primary, Gertz, Jason, primary, and Cox, Angela, primary

Published
2023
Full Text
View/download PDF

74. Supplemental Methods and Supplemental Table from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus

Author

Camp, Nicola J., primary, Lin, Wei-Yu, primary, Bigelow, Alex, primary, Burghel, George J., primary, Mosbruger, Timothy L., primary, Parry, Marina A., primary, Waller, Rosalie G., primary, Rigas, Sushilaben H., primary, Tai, Pei-Yi, primary, Berrett, Kristofer, primary, Rajamanickam, Venkatesh, primary, Cosby, Rachel, primary, Brock, Ian W., primary, Jones, Brandt, primary, Connley, Dan, primary, Sargent, Robert, primary, Wang, Guoying, primary, Factor, Rachel E., primary, Bernard, Philip S., primary, Cannon-Albright, Lisa, primary, Knight, Stacey, primary, Abo, Ryan, primary, Werner, Theresa L., primary, Reed, Malcolm W.R., primary, Gertz, Jason, primary, and Cox, Angela, primary

Published
2023
Full Text
View/download PDF

75. Supplemental Figure Legend from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus

Author

Camp, Nicola J., primary, Lin, Wei-Yu, primary, Bigelow, Alex, primary, Burghel, George J., primary, Mosbruger, Timothy L., primary, Parry, Marina A., primary, Waller, Rosalie G., primary, Rigas, Sushilaben H., primary, Tai, Pei-Yi, primary, Berrett, Kristofer, primary, Rajamanickam, Venkatesh, primary, Cosby, Rachel, primary, Brock, Ian W., primary, Jones, Brandt, primary, Connley, Dan, primary, Sargent, Robert, primary, Wang, Guoying, primary, Factor, Rachel E., primary, Bernard, Philip S., primary, Cannon-Albright, Lisa, primary, Knight, Stacey, primary, Abo, Ryan, primary, Werner, Theresa L., primary, Reed, Malcolm W.R., primary, Gertz, Jason, primary, and Cox, Angela, primary

Published
2023
Full Text
View/download PDF

79. Supplemental Figure from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus

Author

Camp, Nicola J., primary, Lin, Wei-Yu, primary, Bigelow, Alex, primary, Burghel, George J., primary, Mosbruger, Timothy L., primary, Parry, Marina A., primary, Waller, Rosalie G., primary, Rigas, Sushilaben H., primary, Tai, Pei-Yi, primary, Berrett, Kristofer, primary, Rajamanickam, Venkatesh, primary, Cosby, Rachel, primary, Brock, Ian W., primary, Jones, Brandt, primary, Connley, Dan, primary, Sargent, Robert, primary, Wang, Guoying, primary, Factor, Rachel E., primary, Bernard, Philip S., primary, Cannon-Albright, Lisa, primary, Knight, Stacey, primary, Abo, Ryan, primary, Werner, Theresa L., primary, Reed, Malcolm W.R., primary, Gertz, Jason, primary, and Cox, Angela, primary

Published
2023
Full Text
View/download PDF

81. Supplementary Figures 1-6 from Integrated Microfluidic and Imaging Platform for a Kinase Activity Radioassay to Analyze Minute Patient Cancer Samples

Author

Fang, Cong, primary, Wang, Yanju, primary, Vu, Nam T., primary, Lin, Wei-Yu, primary, Hsieh, Yao-Te, primary, Rubbi, Liudmilla, primary, Phelps, Michael E., primary, Müschen, Markus, primary, Kim, Yong-Mi, primary, Chatziioannou, Arion F., primary, Tseng, Hsian-Rong, primary, and Graeber, Thomas G., primary

Published
2023
Full Text
View/download PDF

82. Supplementary Video legend from Integrated Microfluidic and Imaging Platform for a Kinase Activity Radioassay to Analyze Minute Patient Cancer Samples

Author

Fang, Cong, primary, Wang, Yanju, primary, Vu, Nam T., primary, Lin, Wei-Yu, primary, Hsieh, Yao-Te, primary, Rubbi, Liudmilla, primary, Phelps, Michael E., primary, Müschen, Markus, primary, Kim, Yong-Mi, primary, Chatziioannou, Arion F., primary, Tseng, Hsian-Rong, primary, and Graeber, Thomas G., primary

Published
2023
Full Text
View/download PDF

83. Supplementary Video 1 from Integrated Microfluidic and Imaging Platform for a Kinase Activity Radioassay to Analyze Minute Patient Cancer Samples

Author

Fang, Cong, primary, Wang, Yanju, primary, Vu, Nam T., primary, Lin, Wei-Yu, primary, Hsieh, Yao-Te, primary, Rubbi, Liudmilla, primary, Phelps, Michael E., primary, Müschen, Markus, primary, Kim, Yong-Mi, primary, Chatziioannou, Arion F., primary, Tseng, Hsian-Rong, primary, and Graeber, Thomas G., primary

Published
2023
Full Text
View/download PDF

84. Supplementary Methods from Integrated Microfluidic and Imaging Platform for a Kinase Activity Radioassay to Analyze Minute Patient Cancer Samples

Author

Fang, Cong, primary, Wang, Yanju, primary, Vu, Nam T., primary, Lin, Wei-Yu, primary, Hsieh, Yao-Te, primary, Rubbi, Liudmilla, primary, Phelps, Michael E., primary, Müschen, Markus, primary, Kim, Yong-Mi, primary, Chatziioannou, Arion F., primary, Tseng, Hsian-Rong, primary, and Graeber, Thomas G., primary

Published
2023
Full Text
View/download PDF

85. Supplementary Tables 1-2 from Integrated Microfluidic and Imaging Platform for a Kinase Activity Radioassay to Analyze Minute Patient Cancer Samples

Author

Fang, Cong, primary, Wang, Yanju, primary, Vu, Nam T., primary, Lin, Wei-Yu, primary, Hsieh, Yao-Te, primary, Rubbi, Liudmilla, primary, Phelps, Michael E., primary, Müschen, Markus, primary, Kim, Yong-Mi, primary, Chatziioannou, Arion F., primary, Tseng, Hsian-Rong, primary, and Graeber, Thomas G., primary

Published
2023
Full Text
View/download PDF

86. Supplementary Figure Legends 1-6 from Integrated Microfluidic and Imaging Platform for a Kinase Activity Radioassay to Analyze Minute Patient Cancer Samples

Author

Fang, Cong, primary, Wang, Yanju, primary, Vu, Nam T., primary, Lin, Wei-Yu, primary, Hsieh, Yao-Te, primary, Rubbi, Liudmilla, primary, Phelps, Michael E., primary, Müschen, Markus, primary, Kim, Yong-Mi, primary, Chatziioannou, Arion F., primary, Tseng, Hsian-Rong, primary, and Graeber, Thomas G., primary

Published
2023
Full Text
View/download PDF

89. Preoperative hydronephrosis is an independent protective factor of renal function decline after nephroureterectomy for upper tract urothelial carcinoma

Author

Cheng, Pai-Yu, Lee, Hsiang-Ying, Li, Wei-Ming, Huang, Steven K., Liu, Chien-Liang, Chen, I-Hsuan Alan, Lin, Jen-Tai, Lo, Chi-Wen, Yu, Chih-Chin, Wang, Shian-Shiang, Chen, Chuan-Shu, Tseng, Jen-Shu, Lin, Wun-Rong, Yeong-Chin, Jou, Cheong, Ian-Seng, Jiang, Yuan-Hong, Lee, Yu Khun, Chen, Yung-Tai, Chen, Shin-Hong, Chiang, Bing-Juin, Hsueh, Thomas Y., Huang, Chao-Yuan, Wu, Chia-Chang, Lin, Wei Yu, Tsai, Yao-Chou, Yu, Kai-Jie, Huang, Chi-Ping, Huang, Yi-You, and Tsai, Chung-You

Subjects
Cancer Research, Oncology
Abstract

ObjectivesTo evaluate the predictive role of pre-nephroureterectomy (NU) hydronephrosis on post-NU renal function (RF) change and preserved eligibility rate for adjuvant therapy in patients with upper tract urothelial carcinoma (UTUC).Patients and methodsThis retrospective study collected data of 1018 patients from the Taiwan UTUC Collaboration Group registry of 26 institutions. The patients were divided into two groups based on the absence or presence of pre-NU hydronephrosis. Estimated glomerular filtration rate (eGFR) was calculated pre- and post-NU respectively. The one month post-NU RF change, chronic kidney disease (CKD) progression, and the preserved eligibility rate for adjuvant therapy were compared for each CKD stage.Results404 (39.2%) patients without and 614 (60.8%) patients with pre-NU hydronephrosis were enrolled. The median post-NU change in the eGFR was significantly lower in the hydronephrosis group (-3.84 versus -12.88, pp< 0.001) and was an independent protective factor for RF decline after covariate adjustment (OR=0.46, pConclusionPre-NU hydronephrosis is an independent protective predictor for post-NU RF decline, CKD progression, and eligibility for adjuvant therapy. With cautious selection for those unfavorably prognostic, non-metastatic UTUC patients with preoperative hydronephrosis, adjuvant rather than neoadjuvant therapy could be considered due to higher chance of preserving eligibility.

Published
2023
Full Text
View/download PDF

90. Biallelic TET2 mutations confer sensitivity to 5′-azacitidine in acute myeloid leukemia

Author

Stölzel, Friedrich, primary, Fordham, Sarah E., additional, Nandana, Devi, additional, Lin, Wei-Yu, additional, Blair, Helen, additional, Elstob, Claire, additional, Bell, Hayden L., additional, Mohr, Brigitte, additional, Ruhnke, Leo, additional, Kunadt, Desiree, additional, Dill, Claudia, additional, Allsop, Daniel, additional, Piddock, Rachel, additional, Soura, Emmanouela-Niki, additional, Park, Catherine, additional, Fadly, Mohd, additional, Rahman, Thahira, additional, Alharbi, Abrar, additional, Wobus, Manja, additional, Altmann, Heidi, additional, Röllig, Christoph, additional, Wagenführ, Lisa, additional, Jones, Gail L., additional, Menne, Tobias, additional, Jackson, Graham H., additional, Marr, Helen J., additional, Fitzgibbon, Jude, additional, Onel, Kenan, additional, Meggendorfer, Manja, additional, Robinson, Amber, additional, Bziuk, Zuzanna, additional, Bowes, Emily, additional, Heidenreich, Olaf, additional, Haferlach, Torsten, additional, Villar, Sara, additional, Ariceta, Beñat, additional, Diaz, Rosa Ayala, additional, Altschuler, Steven J., additional, Wu, Lani F., additional, Prosper, Felipe, additional, Montesinos, Pau, additional, Martinez-Lopez, Joaquin, additional, Bornhäuser, Martin, additional, and Allan, James M., additional

Published
2023
Full Text
View/download PDF

93. Clinical Guidelines of Patient-Centered Bladder Management of Neurogenic Lower Urinary Tract Dysfunction Due to Chronic Spinal Cord Injury – Part 3

Author

Lin, Yu-Hua, primary, Fan, Yu-Hua, additional, Wu, Chun-Te, additional, Shen, Yuan-Chi, additional, Hu, Ju-Chuan, additional, Huang, Shi-Wei, additional, Chow, Po-Ming, additional, Chang, Po-Chih, additional, Liao, Chun-Hou, additional, Chen, Yu-Chen, additional, Lin, Victor Chia-Hsiang, additional, Hsu, Chih-Chen, additional, Chang, Shang-Jen, additional, Wang, Chung-Cheng, additional, Lin, Wei-Yu, additional, Lin, Chih-Chieh, additional, Jiang, Yuan-Hong, additional, and Kuo, Hann-Chorng, additional

Published
2023
Full Text
View/download PDF

97. Oncologic impact of delay between diagnosis and radical nephroureterectomy

Author

Wu, Kuan-Hsien, primary, Chang, Chao-Hsiang, additional, Wu, Hsi-Chin, additional, Huang, Steven K., additional, Liu, Chien-Liang, additional, Yang, Cheng-Kuang, additional, Li, Jian-Ri, additional, Tseng, Jen-Shu, additional, Lin, Wun-Rong, additional, Yu, Chih-Chin, additional, Lo, Chi-Wen, additional, Huang, Chao-Yuan, additional, Chen, Chung-Hsin, additional, Tsai, Chung-You, additional, Cheng, Pai-Yu, additional, Jiang, Yuan-Hong, additional, Lee, Yu-Khun, additional, Chen, Yung-Tai, additional, Yeh, Ting-Chun, additional, Lin, Jen-Tai, additional, Tsai, Yao-Chou, additional, Hsueh, Thomas Y., additional, Chiang, Bing-Juin, additional, Chiang, Yi-De, additional, Lin, Wei-Yu, additional, Jou, Yeong-Chin, additional, Pang, See-Tong, additional, and Ke, Hung-Lung, additional

Published
2022
Full Text
View/download PDF

98. Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis

Author

Chavarria-Smith, Joseph, primary, Chiu, Cecilia P.C., additional, Jackman, Janet K., additional, Yin, Jianping, additional, Zhang, Juan, additional, Hackney, Jason A., additional, Lin, Wei-Yu, additional, Tyagi, Tulika, additional, Sun, Yonglian, additional, Tao, Janet, additional, Dunlap, Debra, additional, Morton, William D., additional, Ghodge, Swapnil V., additional, Maun, Henry R., additional, Li, Hong, additional, Hernandez-Barry, Hilda, additional, Loyet, Kelly M., additional, Chen, Emily, additional, Liu, John, additional, Tam, Christine, additional, Yaspan, Brian L., additional, Cai, Hao, additional, Balazs, Mercedesz, additional, Arron, Joseph R., additional, Li, Jing, additional, Wittwer, Arthur J, additional, Pappu, Rajita, additional, Austin, Cary D., additional, Lee, Wyne P., additional, Lazarus, Robert A., additional, Sudhamsu, Jawahar, additional, Koerber, James T., additional, and Yi, Tangsheng, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results