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1,133 results on '"Li, Zhaoshen"'

52. ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells

Author

Yang, Jingxuan, Zhang, Zicheng, Zhang, Yuqing, Ni, Xiaoling, Zhang, Guohua, Cui, Xiaobo, Liu, Mingyang, Xu, Can, Zhang, Qiang, Zhu, Huiyun, Yan, Jie, Zhu, Vivian F., Luo, Yusheng, Hagan, John P., Li, Zhaoshen, Fang, Jing, Jatoi, Aminah, Fernandez-Zapico, Martin E., Zheng, Lei, Edil, Barish H., Bronze, Michael S., Houchen, Courtney W., Li, Yi-Ping, and Li, Min

Published
2019
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54. Genome-wide association study of survival in patients with pancreatic adenocarcinoma

Author

Wu, Chen, Kraft, Peter, Stolzenberg-Solomon, Rachael, Steplowski, Emily, Brotzman, Michelle, Xu, Mousheng, Mudgal, Poorva, Amundadottir, Laufey, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, Kooperberg, Charles, Petersen, Gloria M, Zheng, Wei, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Cao, Guangwen, Duell, Eric J, Elena, Joanne W, Gaziano, J Michael, Giovannucci, Edward L, Hallmans, Goran, Hutchinson, Amy, Hunter, David J, Jenab, Mazda, Jiang, Guoliang, Khaw, Kay-Tee, LaCroix, Andrea, Li, Zhaoshen, Mendelsohn, Julie B, Panico, Salvatore, Patel, Alpa V, Qian, Zhi Rong, Riboli, Elio, Sesso, Howard, Shen, Hongbing, Shu, Xiao-Ou, Tjonneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chengfeng, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen, Hoover, Robert, Hartge, Patricia, Fuchs, Charles S, Lin, Dongxin, and Wolpin, Brian M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Digestive Diseases, Prevention, Rare Diseases, Pancreatic Cancer, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adenocarcinoma, Adult, Aged, Aged, 80 and over, Asian People, Biomarkers, Tumor, China, Europe, Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Models, Genetic, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, Principal Component Analysis, Proportional Hazards Models, Protein Tyrosine Phosphatases, Non-Receptor, Survival Rate, White People, Cancer Genetics, Molecular Epidemiology, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background and objectiveSurvival of patients with pancreatic adenocarcinoma is limited and few prognostic factors are known. We conducted a two-stage genome-wide association study (GWAS) to identify germline variants associated with survival in patients with pancreatic adenocarcinoma.MethodsWe analysed overall survival in relation to single nucleotide polymorphisms (SNPs) among 1005 patients from two large GWAS datasets, PanScan I and ChinaPC. Cox proportional hazards regression was used in an additive genetic model with adjustment for age, sex, clinical stage and the top four principal components of population stratification. The first stage included 642 cases of European ancestry (PanScan), from which the top SNPs (p≤10(-5)) were advanced to a joint analysis with 363 additional patients from China (ChinaPC).ResultsIn the first stage of cases of European descent, the top-ranked loci were at chromosomes 11p15.4, 18p11.21 and 1p36.13, tagged by rs12362504 (p=1.63×10(-7)), rs981621 (p=1.65×10(-7)) and rs16861827 (p=3.75×10(-7)), respectively. 131 SNPs with p≤10(-5) were advanced to a joint analysis with cases from the ChinaPC study. In the joint analysis, the top-ranked SNP was rs10500715 (minor allele frequency, 0.37; p=1.72×10(-7)) on chromosome 11p15.4, which is intronic to the SET binding factor 2 (SBF2) gene. The HR (95% CI) for death was 0.74 (0.66 to 0.84) in PanScan I, 0.79 (0.65 to 0.97) in ChinaPC and 0.76 (0.68 to 0.84) in the joint analysis.ConclusionsGermline genetic variation in the SBF2 locus was associated with overall survival in patients with pancreatic adenocarcinoma of European and Asian ancestry. This association should be investigated in additional large patient cohorts.

Published
2014

56. Figure S6 from Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Author

Wu, Hong, primary, Leng, Xuefeng, primary, Liu, Qianshi, primary, Mao, Tianqin, primary, Jiang, Tao, primary, Liu, Yiqiang, primary, Li, Feifei, primary, Cao, Chenhui, primary, Fan, Jun, primary, Chen, Liang, primary, Chen, Yaqi, primary, Yao, Quan, primary, Lu, Shun, primary, Liang, Renchuan, primary, Hu, Lanlin, primary, Liu, Mingxin, primary, Wan, Yejian, primary, Li, Zhaoshen, primary, Peng, Jun, primary, Luo, Qiyu, primary, Zhou, Hang, primary, Yin, Jun, primary, Xu, Ke, primary, Lan, Mei, primary, Peng, Xinhao, primary, Lan, Haitao, primary, Li, Gang, primary, Han, Yongtao, primary, Zhang, Xia, primary, Xiao, Zhi-Xiong Jim, primary, Lang, Jinyi, primary, Wang, Guihua, primary, and Xu, Chuan, primary

Published
2023
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57. Table S4 from Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Author

Wu, Hong, primary, Leng, Xuefeng, primary, Liu, Qianshi, primary, Mao, Tianqin, primary, Jiang, Tao, primary, Liu, Yiqiang, primary, Li, Feifei, primary, Cao, Chenhui, primary, Fan, Jun, primary, Chen, Liang, primary, Chen, Yaqi, primary, Yao, Quan, primary, Lu, Shun, primary, Liang, Renchuan, primary, Hu, Lanlin, primary, Liu, Mingxin, primary, Wan, Yejian, primary, Li, Zhaoshen, primary, Peng, Jun, primary, Luo, Qiyu, primary, Zhou, Hang, primary, Yin, Jun, primary, Xu, Ke, primary, Lan, Mei, primary, Peng, Xinhao, primary, Lan, Haitao, primary, Li, Gang, primary, Han, Yongtao, primary, Zhang, Xia, primary, Xiao, Zhi-Xiong Jim, primary, Lang, Jinyi, primary, Wang, Guihua, primary, and Xu, Chuan, primary

Published
2023
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58. Data from Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Author

Wu, Hong, primary, Leng, Xuefeng, primary, Liu, Qianshi, primary, Mao, Tianqin, primary, Jiang, Tao, primary, Liu, Yiqiang, primary, Li, Feifei, primary, Cao, Chenhui, primary, Fan, Jun, primary, Chen, Liang, primary, Chen, Yaqi, primary, Yao, Quan, primary, Lu, Shun, primary, Liang, Renchuan, primary, Hu, Lanlin, primary, Liu, Mingxin, primary, Wan, Yejian, primary, Li, Zhaoshen, primary, Peng, Jun, primary, Luo, Qiyu, primary, Zhou, Hang, primary, Yin, Jun, primary, Xu, Ke, primary, Lan, Mei, primary, Peng, Xinhao, primary, Lan, Haitao, primary, Li, Gang, primary, Han, Yongtao, primary, Zhang, Xia, primary, Xiao, Zhi-Xiong Jim, primary, Lang, Jinyi, primary, Wang, Guihua, primary, and Xu, Chuan, primary

Published
2023
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59. Supplementary methods from Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Author

Wu, Hong, primary, Leng, Xuefeng, primary, Liu, Qianshi, primary, Mao, Tianqin, primary, Jiang, Tao, primary, Liu, Yiqiang, primary, Li, Feifei, primary, Cao, Chenhui, primary, Fan, Jun, primary, Chen, Liang, primary, Chen, Yaqi, primary, Yao, Quan, primary, Lu, Shun, primary, Liang, Renchuan, primary, Hu, Lanlin, primary, Liu, Mingxin, primary, Wan, Yejian, primary, Li, Zhaoshen, primary, Peng, Jun, primary, Luo, Qiyu, primary, Zhou, Hang, primary, Yin, Jun, primary, Xu, Ke, primary, Lan, Mei, primary, Peng, Xinhao, primary, Lan, Haitao, primary, Li, Gang, primary, Han, Yongtao, primary, Zhang, Xia, primary, Xiao, Zhi-Xiong Jim, primary, Lang, Jinyi, primary, Wang, Guihua, primary, and Xu, Chuan, primary

Published
2023
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60. Supplementary figure legend from Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Author

Wu, Hong, primary, Leng, Xuefeng, primary, Liu, Qianshi, primary, Mao, Tianqin, primary, Jiang, Tao, primary, Liu, Yiqiang, primary, Li, Feifei, primary, Cao, Chenhui, primary, Fan, Jun, primary, Chen, Liang, primary, Chen, Yaqi, primary, Yao, Quan, primary, Lu, Shun, primary, Liang, Renchuan, primary, Hu, Lanlin, primary, Liu, Mingxin, primary, Wan, Yejian, primary, Li, Zhaoshen, primary, Peng, Jun, primary, Luo, Qiyu, primary, Zhou, Hang, primary, Yin, Jun, primary, Xu, Ke, primary, Lan, Mei, primary, Peng, Xinhao, primary, Lan, Haitao, primary, Li, Gang, primary, Han, Yongtao, primary, Zhang, Xia, primary, Xiao, Zhi-Xiong Jim, primary, Lang, Jinyi, primary, Wang, Guihua, primary, and Xu, Chuan, primary

Published
2023
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61. Genome-wide methylation profiling identified methylated KCNA3 and OTOP2 as promising diagnostic markers for esophageal squamous cell carcinoma

Author

Bian, Yan, primary, Gao, Ye, additional, Lu, Chaojing, additional, Tian, Bo, additional, Xin, Lei, additional, Lin, Han, additional, Zhang, Yanhui, additional, Zhang, Xun, additional, Zhou, Siwei, additional, Wan, Kangkang, additional, Zhou, Jun, additional, Li, Zhaoshen, additional, Chen, Hezhong, additional, and Wang, Luowei, additional

Published
2023
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62. Molecular characterization of colorectal adenoma and colorectal cancer via integrated genomic transcriptomic analysis

Author

Pan, Peng, primary, Li, Jingnan, additional, Wang, Bo, additional, Tan, Xiaoyan, additional, Yin, Hekun, additional, Han, Yingmin, additional, Wang, Haobin, additional, Shi, Xiaoli, additional, Li, Xiaoshuang, additional, Xie, Cuinan, additional, Chen, Longfei, additional, Chen, Lanyou, additional, Bai, Yu, additional, Li, Zhaoshen, additional, and Tian, Geng, additional

Published
2023
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63. Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Author

Wu, Hong, primary, Leng, Xuefeng, additional, Liu, Qianshi, additional, Mao, Tianqin, additional, Jiang, Tao, additional, Liu, Yiqiang, additional, Li, Feifei, additional, Cao, Chenhui, additional, Fan, Jun, additional, Chen, Liang, additional, Chen, Yaqi, additional, Yao, Quan, additional, Lu, Shun, additional, Liang, Renchuan, additional, Hu, Lanlin, additional, Liu, Mingxin, additional, Wan, Yejian, additional, Li, Zhaoshen, additional, Peng, Jun, additional, Luo, Qiyu, additional, Zhou, Hang, additional, Yin, Jun, additional, Xu, Ke, additional, Lan, Mei, additional, Peng, Xinhao, additional, Lan, Haitao, additional, Li, Gang, additional, Han, Yongtao, additional, Zhang, Xia, additional, Xiao, Zhi-Xiong Jim, additional, Lang, Jinyi, additional, Wang, Guihua, additional, and Xu, Chuan, additional

Published
2023
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69. The Current Main Types of Capsule Endoscopy

Author

Li, Zhaoshen, Carter, Dan, Eliakim, Rami, Zou, Wenbin, Wu, Hao, Liao, Zhuan, Gong, Zhaotao, Wang, Jinshan, Chung, Joo Won, Song, Si Young, Xiao, Guohua, Duan, Xiaodong, Wang, Xinhong, Li, Zhaoshen, editor, Liao, Zhuan, editor, and McAlindon, Mark, editor

Published
2014
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70. Case Presentations

Author

Liao, Zhuan, Tang, Min, Guo, Qiang, Wang, Bangmao, He, Qiong, Zhi, Fachao, McAlindon, Mark, Carter, Dan, Eliakim, Rami, Koulaouzidis, Anastasios, Douglas, Sarah, Zou, Wenbin, Ge, Zhizheng, Li, Zhaoshen, Li, Zhaoshen, editor, Liao, Zhuan, editor, and McAlindon, Mark, editor

Published
2014
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72. A new method for treating chronic pancreatitis and preventing fibrosis using bioactive calcium silicate ion solution.

Author

Yin, Hua, Zhang, Zhaowenbin, Zhang, Deyu, Peng, Lisi, Xia, Chuanchao, Yang, Xiaoli, Wang, Xinyue, Li, Zhaoshen, Chang, Jiang, and Huang, Haojie

Abstract

Chronic pancreatitis (CP) is a multifactorial fibroinflammatory syndrome. At present, there is no effective way to treat it clinically. In this study, we proposed a new approach by application of a highly active calcium silicate ion solution derived from calcium silicate (CS) bioceramics, which effectively inhibited the development of CP. This bioceramic derived bioactive ionic solution mainly regulated pancreatic acinar cells (PACs), macrophages and pancreatic stellate cells (PSCs) by SiO32− ions to inhibit inflammation and fibrosis and promote acinar regeneration. The possible mechanism of the therapeutic effect of CS ion solution mainly includes the inhibition of PAC apoptosis by down-regulating the c-caspase3 signal pathway and promotion of the regeneration of PACs by up-regulating the WNT/β-catenin signaling pathway. In addition, the CS ion solution also effectively down-regulated the NF-κB signaling pathway to reduce macrophage infiltration and PAC inflammatory factor secretion, thereby reducing PSC mediated pancreatic fibrosis. This bioceramics-based ion solution provides a new idea for disease treatment using biomaterials, which may have the potential for the development of new therapy for CP. [ABSTRACT FROM AUTHOR]

Published
2023
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85. Prepackaged formula low-residue diet vs. self-prepared low-residue diet before colonoscopy: A multicenter randomized controlled trial

Author

Pan, Peng, primary, Gu, Lun, additional, Zhao, Shengbing, additional, Wang, Shuling, additional, Ma, Jiayi, additional, Fu, Hongyu, additional, Chen, Youxiang, additional, He, Shuixiang, additional, Tian, Zibin, additional, Xu, Le, additional, Feng, Zhijie, additional, Li, Yanqing, additional, Yang, Zhuo, additional, Yang, Lei, additional, Wang, Wen, additional, Hou, Qian, additional, Liu, Ting, additional, Li, Chujun, additional, Tian, Dean, additional, Wang, Xiaodi, additional, Gao, Yongmei, additional, Shi, Hanping, additional, Bai, Yu, additional, and Li, Zhaoshen, additional

Published
2023
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94. Additional file 2 of Gastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites

Author

Zhang, Deyu, Weng, Siyuan, Xia, Chuanchao, Ren, Yuqing, Liu, Zaoqu, Xu, Yudi, Yang, Xiaoli, Wu, Ruhao, Peng, Lisi, Sun, Liqi, Zhu, Jiaqi, Liang, Xuesong, Jia, Yin, Wang, Huaizhou, Chen, Qian, Liu, Dongtian, Chen, Yi, Guo, Honglei, Han, Xinwei, Jin, Zhendong, Chen, Cui, Yang, Xia, Li, Zhaoshen, and Huang, Haojie

Abstract

Additional file 2: Table S1. Clinical characteristics of the enrolled patients for serum UPLC-MS/MS-based widely targeted metabolomics.

Published
2023
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95. Additional file 1 of Gastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites

Author

Zhang, Deyu, Weng, Siyuan, Xia, Chuanchao, Ren, Yuqing, Liu, Zaoqu, Xu, Yudi, Yang, Xiaoli, Wu, Ruhao, Peng, Lisi, Sun, Liqi, Zhu, Jiaqi, Liang, Xuesong, Jia, Yin, Wang, Huaizhou, Chen, Qian, Liu, Dongtian, Chen, Yi, Guo, Honglei, Han, Xinwei, Jin, Zhendong, Chen, Cui, Yang, Xia, Li, Zhaoshen, and Huang, Haojie

Abstract

Additional file 1. Supplementary materials and methods: The details of metagenomic bioinformatic analysis and 2bRAD-M bioinformatic analysis.

Published
2023
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96. Additional file 3 of Gastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites

Author

Zhang, Deyu, Weng, Siyuan, Xia, Chuanchao, Ren, Yuqing, Liu, Zaoqu, Xu, Yudi, Yang, Xiaoli, Wu, Ruhao, Peng, Lisi, Sun, Liqi, Zhu, Jiaqi, Liang, Xuesong, Jia, Yin, Wang, Huaizhou, Chen, Qian, Liu, Dongtian, Chen, Yi, Guo, Honglei, Han, Xinwei, Jin, Zhendong, Chen, Cui, Yang, Xia, Li, Zhaoshen, and Huang, Haojie

Abstract

Additional file 3: Figure S1. Diversity differences in the gut microbiome. Figure S2. Comparison of gut microbiota between recovers without GI symptoms at 3 months of follow-up after COVID-19 and those with mild disease. Figure S3. Diversity differences in the oral microbiome. Figure S4. Comparison of oral microbiota between recovers without GI symptoms at 3 months of follow-up after COVID-19 and those with mild disease. Figure S5. Alteration of specific metabolites in patient serum.

Published
2023
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97. Additional file 5 of Gastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites

Author

Zhang, Deyu, Weng, Siyuan, Xia, Chuanchao, Ren, Yuqing, Liu, Zaoqu, Xu, Yudi, Yang, Xiaoli, Wu, Ruhao, Peng, Lisi, Sun, Liqi, Zhu, Jiaqi, Liang, Xuesong, Jia, Yin, Wang, Huaizhou, Chen, Qian, Liu, Dongtian, Chen, Yi, Guo, Honglei, Han, Xinwei, Jin, Zhendong, Chen, Cui, Yang, Xia, Li, Zhaoshen, and Huang, Haojie

Abstract

Additional file 5: Table S3. Differential metabolites in serum between follow-up group and normal group.

Published
2023
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98. Additional file 4 of Gastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites

Author

Zhang, Deyu, Weng, Siyuan, Xia, Chuanchao, Ren, Yuqing, Liu, Zaoqu, Xu, Yudi, Yang, Xiaoli, Wu, Ruhao, Peng, Lisi, Sun, Liqi, Zhu, Jiaqi, Liang, Xuesong, Jia, Yin, Wang, Huaizhou, Chen, Qian, Liu, Dongtian, Chen, Yi, Guo, Honglei, Han, Xinwei, Jin, Zhendong, Chen, Cui, Yang, Xia, Li, Zhaoshen, and Huang, Haojie

Abstract

Additional file 4: Table S2. Differential metabolites in serum between follow-up group and mild group.

Published
2023
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