Search

This study was conducted to investigate the free radical-scavenging activity and antioxidant activity of silk sericin hydrolysates (SSH). SSH were obtained by hydrolysis of silk sericin with alcalase, trypsin, neutrase, bromelin, papain and flavourzyme. Its ability to scavenge 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonicacid) (ABTS) cation radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals was determined by ultraviolet spectrophotometry. The antioxidant activities of the SSH, including lipid peroxidation in linoleic acid system, reducing power and ferrous ion chelating ability, were evaluated. The results showed that different protease hydrolysates possessed different ability to quench the ABTS cation radicals and DPPH radicals. Among those tested, alcalase hydrolysate exhibits the highest scavenging activity than other proteases (P < 0.05). Alcalase hydrolysate exerted the highest peroxidation inhibition than other proteases (P < 0.05). The reducing power and ferrous ion chelating ability of six SSH were significant. These results indicated that six SSH were natural antioxidants with potent antioxidative activity. PRACTICAL APPLICATIONS Most of silk sericin must be removed during raw silk production at the reeling mill and the other stages of silk processing. At present, silk sericin is mostly discarded in the silk processing wastewater. If silk sericin was recovered and recycled, it could represent a significant economic and social benefit. Silk sericin is a natural macromolecular protein derived from silkworm Bombyx mori. Silk sericin is useful because of its antioxidant activity. Silk sericin can be cross-linked, copolymerized and blended with other macromolecular materials, especially artificial polymers, to produce materials with improved properties. The protein is also used as an improving reagent or a coating material for natural and artificial fibers, fabrics and articles. The materials modified with silk sericin and sericin composites are useful as degradable biomaterials, biomedical materials and functional membranes. [ABSTRACT FROM AUTHOR]

Various thiobenzamides are directly synthesized from multiform substrates benzylamines, benzylamines/aldehydes, and N-alkyl benzylamines. [ABSTRACT FROM AUTHOR]

The product rotational polarizations of reaction Li+HF→LiF+H at different collision energies, as well as at the different vibrational states and rotational states, are calculated by using the quasi-classical trajectory method based on a new potential energy surface constructed by Aguado et al. [J. Chem. Phys. 119 (2003) 10088]. We investigate the alignment and the orientation of the product molecule by calculating the P(θr, ϕr) distributions describing polar angle distribution, the P(θr) distributions describing the k–j′ correlation and the P(ϕr) distributions describing the k–k′–j′ correlation. We also explore the dependence of reaction probabilities and cross sections on the rotational and vibrational quantum number of the title reaction. It is concluded that the vibrational state has more important impact on the angular distribution, reaction probability and cross section. [ABSTRACT FROM AUTHOR]

The important synthons are readily available in the presence of NaSH. [ABSTRACT FROM AUTHOR]

Systematic evaluation of the effectiveness and safety of Xiaoer Xiaoji Zhike Oral Liqud combined with azithromycin in the treatment of mycoplasma pneumonia in children. Clinical literatures were retrieved from PubMed, Cochrane Library, EMbase, VIP, CNKI, SinoMed, WanFang from inception to September 2019. Two reviewers independently screened out the literatures, extracted data and assessed the risk of bias of the included studies. Then, Meta-analysis was performed by RevMan 5.3 software. A total of 17 RCT were included, involving 1 712 patients. In this study, there were two subgroups by the application approach of azithromycin: oral azithromycin subgroup and intravenous azithromycin subgroup. According to Meta-analysis results, in terms of the alleviation of clinical symptoms and signs, such as shortening of antifebrile time, cough disappeared time, rales disappearance time, and lung X-ray infiltrating shadow disappearance time, Xiaoer Xiaoji Zhike Oral Liquid combined with oral azithromycin or intravenous azithromycin were better than single-dose azithromycin; in the aspect of the improvement of the overall effective rate, the two combination subgroups were better than the single-use azithromycin; In terms of the decline of IgM, the combination subgroups were also more efficient than the single-use azithromycin, with statistically significant differences. In terms of the incidence of adverse reactions, there was no significant difference between the two combination subgroups and the single-use azithromycin in children, and no serious adverse reactions were found. In inclusion, Xiaoer Xiaoji Zhike Oral Liquid combined with azithromycin can improve the clinical efficacy in treating pediatric mycoplasma pneumonia, with a high safety. Due to the limited quantity and quality of the included studies, more high-quality studies are needed to verify the above conclusion.

The theory of " treating same syndrome with different methods" has been widely used in traditional Chinese medicine( TCM). It originated from Treatise on Febrile and Miscellaneous Diseases,and had objective formation factors. The " syndrome" in TCM was a comprehensive manifestation of etiology,characteristics,disease location and trend of disease. Considering the rich connotation of " syndrome",the diverse treatment methods,and the complex ingredients in prescriptions,different specific methods or prescriptions have been often applied to treat the same syndrome. Therefore,based on the theory of " treating same syndrome with different methods",the concept of " prescriptions corresponding to syndromes" was extended,suggesting one syndrome treated with several different prescriptions. Moreover,the concept of " prescription corresponding to syndrome" doesn't refer to a random match between the " syndrome" and the " prescription". Instead,it would refine and objectify the " same syndrome" and seek subtle differences in symptoms,signs and chemical indicators of different diseases and individuals. It further embodied the new diagnosis and treatment model of " pathogenesis combined with pathology,drug properties combined with pharmacology". As a result,the nature of " treating same syndrome with different methods" lies in different microscopic pathological changes or trends,which traditionally expressed as the same syndrome with different symptoms,the same syndrome with different trends,and the same syndrome with different diseases and the same syndrome with different physiques. Therefore,by enriching the connotation of " syndrome",and further defining its objective pathology and development trend,the correspondence between " syndrome" and " prescription" became more precise. By carefully identifying the different characterizations,trends and prognosis in same syndrome,medical practitioners could give individual and dynamic prescriptions,so as to improve the clinical efficacy.