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54. Methane Conversion to Methanol Using Au/ZSM-5 is Promoted by Carbon

Author

Cao, Jingxian, primary, Lewis, Richard J., additional, Qi, Guodong, additional, Bethell, Donald, additional, Howard, Mark J., additional, Harrison, Brian, additional, Yao, Bingqing, additional, He, Qian, additional, Morgan, David J., additional, Ni, Fenglou, additional, Sharma, Pankaj, additional, Kiely, Christopher J., additional, Li, Xu, additional, Deng, Feng, additional, Xu, Jun, additional, and Hutchings, Graham J., additional

Published
2023
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60. Ciguatoxin and Ciguatera

Author

Lewis, Richard J., Vetter, Irina, Gopalakrishnakone, P., Editor-in-chief, Haddad Jr., Vidal, editor, Tubaro, Aurelia, editor, Kim, Euikyung, editor, and Kem, William R., editor

Published
2016
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61. N-Sulfonylphenoxazines as neuronal calcium ion channel blockersElectronic supplementary information (ESI) available: Synthesis of 2, NMR spectra, rat plasma stability and liver microsomal stability studies. See DOI: https://doi.org/10.1039/d4md00336e

Author

Schmit, Matthieu, Hasan, Md. Mahadhi, Dongol, Yashad, Cardoso, Fernanda C., Kuiper, Michael J., Lewis, Richard J., Duggan, Peter J., and Tuck, Kellie L.

Abstract

Neuropathic pain is a type of chronic pain, usually caused by nerve damage, that responds poorly to traditional pain therapies. The N-type calcium channel (CaV2.2) is a well-validated pharmacological target to treat this condition. In order to further improve the inhibition of the N-type calcium channel relative to previously described inhibitors, and also address their problematic instability in blood plasma, the development of N-sulfonylphenoxazines as new calcium channel inhibitors was pursued. A series of N-sulfonylphenoxazines bearing ammonium side chains were synthesised and tested for their ability to inhibit both CaV2.2 and CaV3.2 (T-type) neuronal ion channels. Compounds with low micromolar activity in CaV2.2 were identified, equivalent to the most effective reported for this class of bioactive, and calculations based on their physical and chemical characteristics suggest that the best performing compounds have a high likelihood of being able to penetrate the blood–brain barrier. Representative N-sulfonylphenoxazines were tested for their stability in rat plasma and were found to be much more resilient than the previously reported N-acyl analogues. These compounds were also found to be relatively stable in an in vitroliver microsome metabolism model, the first time that this has been investigated for this class of compound. Finally, molecular modelling of the CaV2.2 channel was used to gain an understanding of the mode of action of these inhibitors at a molecular level. They appear to bind in a part of the channel, in and above its selectivity filter, in a way that hinders its ability to undergo the conformational changes required to open and allow calcium ions to pass through.

Published
2024
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62. Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analoguesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00714f

Author

Bispat, Anjie S., Cardoso, Fernanda C., Hasan, Md. Mahadhi, Dongol, Yashad, Wilcox, Ricki, Lewis, Richard J., Duggan, Peter J., and Tuck, Kellie L.

Abstract

Building on previous investigations, structural modifications to the neuronal calcium ion channel blocker MONIRO-1 and related compounds were conducted that included replacement of the amide linker with an aniline and isosteric sulfonamide moiety, and the previously used strategy of substitution of the guanidinium group with less hydrophilic amine functionalities. A comprehensive SAR study revealed a number of phenoxyaniline and sulfonamide compounds that were more potent or had similar potency for the CaV2.2 and CaV3.2 channel compared to MONIRO-1 when evaluated in a FLIPR-based intracellular calcium response assay. Cytotoxicity investigations indicated that the sulfonamide analogues were well tolerated by Cos-7 cells at dosages required to inhibit both calcium ion channels. The sulfonamide derivatives were the most promising CaV2.2 inhibitors developed by us to date due, possessing high stability in plasma, low toxicity (estimated therapeutic index > 10), favourable CNS MPO scores (4.0–4.4) and high potency and selectivity, thereby, making this class of compounds suitable candidates for future in vivostudies.

Published
2024
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66. A comparative study of palladium-gold and palladium-tin catalysts in the direct synthesis of H2O2.

Author

Kovačič, Dávid, Lewis, Richard J., Crombie, Caitlin M., Morgan, David J., Davies, Thomas E., López-Martín, Ángeles, Qin, Tian, Allen, Christopher S., Edwards, Jennifer. K., Chen, Liwei, Skjøth-Rasmussen, Martin Skov, Liu, Xi, and Hutchings, Graham J.

Subjects
*CATALYST synthesis, *SCRAP metals, *COMPARATIVE studies, *CATALYSTS, *DISPERSION (Chemistry)
Abstract

Herein we evaluate the promotive effect of Au and Sn incorporation into supported Pd nanoparticles for the direct synthesis of H2O2 from molecular H2 and O2. The introduction of both secondary metal modifiers was found to result in a significant enhancement in catalytic performance, although, in the case of the PdSn system, it was identified that relatively large quantities of the secondary metal were required to rival the activity observed over optimal Au-containing formulations, with the 0.25%Pd–2.25%Sn/TiO2 catalyst offering comparable H2O2 synthesis rates to the optimised 0.25%Pd–0.25%Au/TiO2 formulation. The introduction of Sn was found to considerably improve Pd dispersion, correlating with an improvement in selective H2 utilisation. Notably, the optimal PdSn catalyst identified in this work achieves superior H2O2 selectivities compared to the PdAu analogue and is able to rival the performance of state-of-the-art materials. [ABSTRACT FROM AUTHOR]

Published
2023
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67. A comparative study of palladium-gold and palladium-tin catalysts in the direct synthesis of H2O2.

Author

Kovačič, Dávid, Lewis, Richard J., Crombie, Caitlin M., Morgan, David J., Davies, Thomas E., López-Martín, Ángeles, Qin, Tian, Allen, Christopher S., Edwards, Jennifer. K., Chen, Liwei, Skjøth-Rasmussen, Martin Skov, Liu, Xi, and Hutchings, Graham J.

Subjects
CATALYST synthesis, SCRAP metals, COMPARATIVE studies, CATALYSTS, DISPERSION (Chemistry)
Abstract

Herein we evaluate the promotive effect of Au and Sn incorporation into supported Pd nanoparticles for the direct synthesis of H2O2 from molecular H2 and O2. The introduction of both secondary metal modifiers was found to result in a significant enhancement in catalytic performance, although, in the case of the PdSn system, it was identified that relatively large quantities of the secondary metal were required to rival the activity observed over optimal Au-containing formulations, with the 0.25%Pd–2.25%Sn/TiO2 catalyst offering comparable H2O2 synthesis rates to the optimised 0.25%Pd–0.25%Au/TiO2 formulation. The introduction of Sn was found to considerably improve Pd dispersion, correlating with an improvement in selective H2 utilisation. Notably, the optimal PdSn catalyst identified in this work achieves superior H2O2 selectivities compared to the PdAu analogue and is able to rival the performance of state-of-the-art materials. [ABSTRACT FROM AUTHOR]

Published
2023
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73. Correction to “Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction”

Author

Begnini, Fabio, primary, Geschwindner, Stefan, additional, Johansson, Patrik, additional, Wissler, Lisa, additional, Lewis, Richard J., additional, Danelius, Emma, additional, Luttens, Andreas, additional, Matricon, Pierre, additional, Carlsson, Jens, additional, Lenders, Stijn, additional, König, Beate, additional, Friedel, Anna, additional, Sjö, Peter, additional, Schiesser, Stefan, additional, and Kihlberg, Jan, additional

Published
2023
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74. Selective Ammoximation of Ketones via In Situ H2O2 Synthesis

Author

Lewis, Richard J., primary, Ueura, Kenji, additional, Liu, Xi, additional, Fukuta, Yukimasa, additional, Qin, Tian, additional, Davies, Thomas E., additional, Morgan, David J., additional, Stenner, Alex, additional, Singleton, James, additional, Edwards, Jennifer K., additional, Freakley, Simon J., additional, Kiely, Christopher J., additional, Chen, Liwei, additional, Yamamoto, Yasushi, additional, and Hutchings, Graham J., additional

Published
2023
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92. Methane Oxidation to Methanol

Author

Dummer, Nicholas F., primary, Willock, David J., additional, He, Qian, additional, Howard, Mark J., additional, Lewis, Richard J., additional, Qi, Guodong, additional, Taylor, Stuart H., additional, Xu, Jun, additional, Bethell, Don, additional, Kiely, Christopher J., additional, and Hutchings, Graham J., additional

Published
2022
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