88,960 results on '"Lerner A"'
Search Results
52. On some improved weighted weak type inequalities
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Lerner, Andrei K., Li, Kangwei, Ombrosi, Sheldy, and Rivera-Ríos, Israel P.
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Mathematics - Classical Analysis and ODEs ,42B20 - Abstract
In this paper we obtain the sharp quantitative matrix weighted weak type bounds for the Christ--Goldberg maximal operator $M_{W,p}$ in the case $1
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- 2024
53. Elasticity of self-organized frustrated disordered spring networks
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Pettinari, Tommaso, Düring, Gustavo, and Lerner, Edan
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Condensed Matter - Soft Condensed Matter ,Condensed Matter - Statistical Mechanics - Abstract
There have been some interesting recent advances in understanding the notion of mechanical disorder in structural glasses and the statistical mechanics of these systems' low-energy excitations. Here we contribute to these advances by studying a minimal model for structural glasses' elasticity in which the degree of mechanical disorder -- as characterized by recently introduced dimensionless quantifiers -- is readily tunable over a very large range. We comprehensively investigate a number of scaling laws observed for various macro-, meso- and microscopic elastic properties, and rationalize them using scaling arguments. Interestingly, we demonstrate that the model features the universal quartic glassy vibrational density of states as seen in many atomistic and molecular models of structural glasses formed by cooling a melt. The emergence of this universal glassy spectrum highlights the role of self-organization (towards mechanical equilibrium) in its formation, and elucidates why models featuring structural frustration alone do not feature the same universal glassy spectrum. Finally, we discuss relations to existing work in the context of strain-stiffening of elastic networks and of low-energy excitations in structural glasses, in addition to future research directions., Comment: 9 pages, 7 figures
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- 2024
54. Cross-modal Retrieval for Knowledge-based Visual Question Answering
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Lerner, Paul, Ferret, Olivier, and Guinaudeau, Camille
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Computer Science - Computation and Language ,Computer Science - Information Retrieval - Abstract
Knowledge-based Visual Question Answering about Named Entities is a challenging task that requires retrieving information from a multimodal Knowledge Base. Named entities have diverse visual representations and are therefore difficult to recognize. We argue that cross-modal retrieval may help bridge the semantic gap between an entity and its depictions, and is foremost complementary with mono-modal retrieval. We provide empirical evidence through experiments with a multimodal dual encoder, namely CLIP, on the recent ViQuAE, InfoSeek, and Encyclopedic-VQA datasets. Additionally, we study three different strategies to fine-tune such a model: mono-modal, cross-modal, or joint training. Our method, which combines mono-and cross-modal retrieval, is competitive with billion-parameter models on the three datasets, while being conceptually simpler and computationally cheaper.
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- 2024
55. Qualitatively Distinct Signaling in Cells: The Informational Landscape of Amplitude and Frequency Encoding
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Givré, Alan, Colman-Lerner, Alejandro, and Dawson, Silvina Ponce
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Quantitative Biology - Cell Behavior ,Physics - Biological Physics - Abstract
Cells continuously sense their surroundings to detect modifications and generate responses. Very often changes in extracellular concentrations initiate signaling cascades that eventually result in changes in gene expression. Increasing stimulus strengths can be encoded in increasing concentration amplitudes or increasing activation frequencies of intermediaries of the pathway. In this paper we show that the different way in which amplitude and frequency encoding map environmental changes endow cells with qualitatively different information transmission capabilities. While amplitude encoding is optimal for a limited range of stimuli strengths, frequency encoding can transmit information with equal reliability over much broader ranges. The qualitative difference between the two strategies stems from the scale invariant discriminating power of the first transducing step in frequency codification. The apparently redundant combination of both strategies in some cell types may then serve the purpose of expanding the span over which stimulus strengths can be reliably discriminated. In this paper we discuss a possible example of this mechanism in yeast., Comment: 12 pages, 5 figures
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- 2024
56. CXL and the Return of Scale-Up Database Engines
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Lerner, Alberto and Alonso, Gustavo
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Computer Science - Databases ,Computer Science - Performance - Abstract
The trend toward specialized processing devices such as TPUs, DPUs, GPUs, and FPGAs has exposed the weaknesses of PCIe in interconnecting these devices and their hosts. Several attempts have been proposed to improve, augment, or downright replace PCIe, and more recently, these efforts have converged into a standard called Compute Express Link (CXL). CXL is already on version 2.0 in terms of commercial availability, but its potential to radically change the conventional server architecture has only just started to surface. For example, CXL can increase the bandwidth and quantity of memory available to any single machine beyond what that machine can originally provide, most importantly, in a manner that is fully transparent to software applications. We argue, however, that CXL can have a broader impact beyond memory expansion and deeply affect the architecture of data-intensive systems. In a nutshell, while the cloud favored scale-out approaches that grew in capacity by adding full servers to a rack, CXL brings back scale-up architectures that can grow by fine-tuning individual resources, all while transforming the rack into a large shared-memory machine. In this paper, we describe why such architectural transformations are now possible, how they benefit emerging heterogeneous hardware platforms for data-intensive systems, and the associated research challenges.
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- 2024
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57. Text vs Patient Portal Messaging to Improve Influenza Vaccination Coverage
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Szilagyi, Peter G, Duru, O Kenrik, Casillas, Alejandra, Ong, Michael K, Vangala, Sitaram, Tseng, Chi-Hong, Albertin, Christina, Humiston, Sharon G, Clark, Emma, Ross, Mindy K, Evans, Sharon A, Sloyan, Michael, Fox, Craig R, and Lerner, Carlos
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Biomedical and Clinical Sciences ,Health Services and Systems ,Public Health ,Clinical Sciences ,Health Sciences ,Pneumonia & Influenza ,Influenza ,Vaccine Related ,Immunization ,Clinical Research ,Clinical Trials and Supportive Activities ,Prevention ,Health Services ,Prevention of disease and conditions ,and promotion of well-being ,6.1 Pharmaceuticals ,3.4 Vaccines ,Evaluation of treatments and therapeutic interventions ,Infection ,Good Health and Well Being ,Humans ,Text Messaging ,Reminder Systems ,Male ,Patient Portals ,Female ,Influenza ,Human ,Influenza Vaccines ,Middle Aged ,Vaccination Coverage ,Adult ,Aged ,Electronic Health Records ,Vaccination ,Opthalmology and Optometry ,Public Health and Health Services ,Clinical sciences ,Health services and systems - Abstract
ImportanceIncreasing influenza vaccination rates is a public health priority. One method recommended by the US Centers for Disease Control and Prevention and others is for health systems to send reminders nudging patients to be vaccinated.ObjectiveTo evaluate and compare the effect of electronic health record (EHR)-based patient portal reminders vs text message reminders on influenza vaccination rates across a health system.Design, setting, and participantsThis 3-arm randomized clinical trial was conducted from September 7, 2022, to April 30, 2023, among primary care patients within the University of California, Los Angeles (UCLA) health system.InterventionsArm 1 received standard of care. The health system sent monthly reminder messages to patients due for an influenza vaccine by portal (arm 2) or text (arm 3). Arm 2 had a 2 × 2 nested design, with fixed vs responsive monthly reminders and preappointment vs no preappointment reminders. Arm 3 had 1 × 2 design, with preappointment vs no preappointment reminders. Preappointment reminders for eligible patients were sent 24 and 48 hours before scheduled primary care visits. Fixed reminders (in October, November, and December) involved identical messages via portal or text. Responsive portal reminders involved a September message asking patients about their plans for vaccination, with a follow-up reminder if the response was affirmative but the patient was not yet vaccinated.Main outcomes and measuresThe primary outcome was influenza vaccination by April 30, 2023, obtained from the UCLA EHR, including vaccination from pharmacies and other sources.ResultsA total of 262 085 patients (mean [SD] age, 45.1 [20.7] years; 237 404 [90.6%] adults; 24 681 [9.4%] children; 149 349 [57.0%] women) in 79 primary care practices were included (87 257 in arm 1, 87 478 in arm 2, and 87 350 in arm 3). At the entire primary care population level, none of the interventions improved influenza vaccination rates. All groups had rates of approximately 47%. There was no statistical or clinically significant improvement following portal vs text, preappointment reminders vs no preappointment reminders (portal and text reminders combined), or responsive vs fixed monthly portal reminders.Conclusions and relevanceAt the population level, neither portal nor text reminders for influenza vaccination were effective. Given that vaccine hesitancy may be a major reason for the lack of impact of portal or text reminders, more intensive interventions by health systems are needed to raise influenza vaccination coverage levels.Trial registrationClinicalTrials.gov Identifier: NCT05525494.
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- 2024
58. A response to and caution of “Language is a critical mediator of autistic experiences within the criminal justice system”
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Shea, Lindsay, Cooper, Dylan, Wilson, Amy Blank, Hyatt, Jordan, Msipa, Dianah, Hofvander, Björn, Øverland, Svein, da Silva, Wainesten Carmago, Mogavero, Melanie, Green, Derek, Wall, Nina, Lerner, Matthew, Stahmer, Aubyn, Hooven, Kathy, Bornman, Juan, Robinson, Khylil, and Burke, John
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Biomedical and Clinical Sciences ,Applied and Developmental Psychology ,Clinical and Health Psychology ,Neurosciences ,Psychology ,Peace ,Justice and Strong Institutions ,Humans ,Language ,Autistic Disorder ,Criminal Law ,Autism Spectrum Disorder ,Clinical Sciences ,Developmental & Child Psychology ,Applied and developmental psychology ,Clinical and health psychology - Published
- 2024
59. SoK: Technical Implementation and Human Impact of Internet Privacy Regulations
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Birrell, Eleanor, Rodolitz, Jay, Ding, Angel, Lee, Jenna, McReynolds, Emily, Hutson, Jevan, and Lerner, Ada
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Computer Science - Computers and Society - Abstract
Growing recognition of the potential for exploitation of personal data and of the shortcomings of prior privacy regimes has led to the passage of a multitude of new online privacy regulations. Some of these laws -- notably the European Union's General Data Protection Regulation (GDPR) and the California Consumer Privacy Act (CCPA) -- have been the focus of large bodies of research by the computer science community, while others have received less attention. In this work, we analyze a set of Internet privacy and data protection regulations drawn from around the world -- both those that have frequently been studied by computer scientists and those that have not -- and develop a taxonomy of rights granted and obligations imposed by these laws. We then leverage this taxonomy to systematize 270 technical research papers published in computer science venues that investigate the impact of these laws and explore how technical solutions can complement legal protections. Finally, we analyze the results in this space through an interdisciplinary lens and make recommendations for future work at the intersection of computer science and legal privacy.
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- 2023
60. Advancing Image Retrieval with Few-Shot Learning and Relevance Feedback
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Lerner, Boaz, Darshan, Nir, and Ben-Ari, Rami
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Computer Science - Computer Vision and Pattern Recognition - Abstract
With such a massive growth in the number of images stored, efficient search in a database has become a crucial endeavor managed by image retrieval systems. Image Retrieval with Relevance Feedback (IRRF) involves iterative human interaction during the retrieval process, yielding more meaningful outcomes. This process can be generally cast as a binary classification problem with only {\it few} labeled samples derived from user feedback. The IRRF task frames a unique few-shot learning characteristics including binary classification of imbalanced and asymmetric classes, all in an open-set regime. In this paper, we study this task through the lens of few-shot learning methods. We propose a new scheme based on a hyper-network, that is tailored to the task and facilitates swift adjustment to user feedback. Our approach's efficacy is validated through comprehensive evaluations on multiple benchmarks and two supplementary tasks, supported by theoretical analysis. We demonstrate the advantage of our model over strong baselines on 4 different datasets in IRRF, addressing also retrieval of images with multiple objects. Furthermore, we show that our method can attain SoTA results in few-shot one-class classification and reach comparable results in binary classification task of few-shot open-set recognition., Comment: A short version of this paper was presented in ICCV-Out Of Distribution Generalization on Computer Vision (OOD-CV) Workshop 2023. See also https://github.com/eccv22-ood-workshop/eccv22-ood-workshop.github.io/blob/new/camera_ready/CameraReady%2053.pdf
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- 2023
61. Effects of coordination and stiffness scale-separation in disordered elastic networks
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Lerner, Edan
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Condensed Matter - Soft Condensed Matter ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
Many fibrous materials are modeled as elastic networks featuring a substantial separation between the stiffness scales that characterize different microscopic deformation modes of the network's constituents. This scale separation has been shown to give rise to emergent complexity in these systems' linear and nonlinear mechanical response. Here we study numerically a simple model featuring said stiffness scale-separation in two-dimensions and show that its mechanical response is governed by the competition between the characteristic stiffness of collective nonphononic soft modes of the stiff subsystem, and the characteristic stiffness of the soft interactions. We present and rationalize the behavior of the shear modulus of our complex networks across the unjamming transition at which the stiff subsystem alone loses its macroscopic mechanical rigidity. We further establish a relation in the soft-interaction-dominated regime between the shear modulus, the characteristic frequency of nonphononic vibrational modes, and the mesoscopic correlation length that marks the crossover from a disorder-dominated response to local mechanical perturbations in the near-field, to a linear, continuum-like response in the far field. The effects of spatial dimension on the observed scaling behavior are discussed, in addition to the interplay between stiffness scales in strain-stiffened networks, which is relevant to understanding the nonlinear mechanics of non-Brownian fibrous biomatter., Comment: 10 pages, 9 figures. v2: slightly modified analysis and additional figure
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- 2023
62. Endoscopic endonasal resection of olfactory tract hamartoma for pediatric epilepsy
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Kundishora, Adam J., Reeves, Benjamin C., Lerner, David K., Storm, Phillip B., Prelack, Marisa S., Palmer, James N., Adappa, Nithin D., and Kennedy, Benjamin C.
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- 2024
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63. Meaningful Writing Projects among Multilingual Undergraduate Writers: Personal, Practical and Developmental
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Qianqian Zhang-Wu, Alison Stephens, and Neal Lerner
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Our research explores the meaningful writing experiences of 325 undergraduate students who self-identify as multilingual. Through qualitative coding of open-ended survey data, we found that respondents considered their writing meaningful when it allowed them to make personal and relevant connections and learn new skills and strategies. Our findings are aligned with the results of "The Meaningful Writing Project," suggesting that the ways all students find their writing meaningful are interwoven with their identities, histories, and aspirations. After presenting our analysis of multilingual students' responses, we posit several conditions for teaching writing across the curriculum that allow complex, mobile language users to exercise their personal, social, and linguistic resources and have the opportunities for meaningful writing experiences.
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- 2023
64. Microbial Transglutaminase Is Immunogenic and Potentially Pathogenic in Pediatric Celiac Disease
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Matthias Torsten and Lerner Aaron
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celiac disease ,microbiome ,food additive ,gluten ,cross linking ,microbial transglutaminase ,Pediatrics ,RJ1-570 - Abstract
The enzyme microbial transglutaminase is heavily used in the food processing industries to ameliorate food qualities and elongate the products' shelf life. As a protein's glue, it cross-links gliadin peptides, creating neo-complexes that are immunogenic and potentially pathogenic to celiac disease communities. Even lacking sequence identity, it imitates functionally the endogenous tissue transglutaminase, known to be the autoantigen of celiac disease and representing an undisputable key player in celiac disease initiation and progress. The present review expend on the enzyme characteristics, exogenous intestinal sources, its cross-linking avidity to gluten or gliadin, turning naïve protein to immunogenic ones. Several observation on microbial transglutaminase cross linked complexes immunogenicity in celiac patients are reviewed and its pathogenicity is summarized. Warnings on its potential risks for the gluten dependent conditions are highlighted. When substantiated, it might represent a new environmental factor of celiac disease genesis. It is hoped that the presented knowledge will encourage further research to explore the mechanism and the pathogenic pathways taken by the gliadin cross linked enzyme in driving celiac disease.
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- 2018
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65. Clinical Characteristics of Youth with Trichotillomania (Hair-Pulling Disorder) and Excoriation (Skin-Picking) Disorder
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Ricketts, Emily J., Peris, Tara S., Grant, Jon E., Valle, Stephanie, Cavic, Elizabeth, Lerner, Juliette E., Lochner, Christine, Stein, Dan J., Dougherty, Darin D., O’Neill, Joseph, Woods, Douglas W., Keuthen, Nancy J., and Piacentini, John
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- 2024
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66. Results from a Pilot Randomized Controlled Trial of a Single-Session Growth-Mindset Intervention for Internalizing Symptoms in Autistic Youth
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Gerber, Alan H., Nahmias, Allison, Schleider, Jessica L., and Lerner, Matthew D.
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- 2024
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67. The Preparation of Iron-Based Scaffolds with an Antibacterial Coating Based on Polylactic Acid and Vancomycin
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Lozhkomoev, A. S., Kazantsev, S. O., Bakina, O. V., Buyakov, A. S., Senkina, E. I., Krinitcyn, M. G., Ivanyuk, V. A., Sharipova, A. F., and Lerner, M. I.
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- 2024
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68. New photonic conservation laws in parametric nonlinear optics
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Lerner, Gavriel, Tzur, Matan Even, Neufeld, Ofer, Fleischer, Avner, and Cohen, Oren
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Physics - Optics - Abstract
Conservation laws are one of the most generic and useful concepts in physics. In nonlinear optical parametric processes, conservation of photonic energy, momenta and parity often lead to selection rules, restricting the allowed polarization and frequencies of the emitted radiation. Here we present a new scheme to derive conservation laws in optical parametric processes in which many photons are annihilated and a single new photon is emitted. We then utilize it to derive two new such conservation laws. Conservation of reflection-parity (RP) arises from a generalized reflection symmetry of the polarization in a superspace, analogous to the superspace employed in the study of quasicrystals. Conservation of space-time-parity (STP) similarly arises from space-time reversal symmetry in superspace. We explore these new conservation laws numerically in the context of high harmonic generation and outline experimental set-ups where they can be tested.
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- 2023
69. Pushing the high count rate limits of scintillation detectors for challenging neutron-capture experiments
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Correa, J. Balibrea, Lerendegui-Marco, J., Babiano-Suarez, V., Domingo-Pardo, C., Ladarescu, I., Tarifeño-Saldivia, A., Alcayne, V., Cano-Ott, D., González-Romero, E., Martínez, T., Mendoza, E., de Rada, A. Pérez, del Olmo, J. Plaza, Sánchez-Caballero, A., Casanovas, A., Calviño, F., Valenta, S., Aberle, O., Altieri, S., Amaducci, S., Andrzejewski, J., Bacak, M., Beltrami, C., Bennett, S., Bernardes, A. P., Berthoumieux, E., Beyer, R., Boromiza, M., Bosnar, D., Caamaño, M., Calviani, M., Castelluccio, D. M., Cerutti, F., Cescutti, G., Chasapoglou, S., Chiaveri, E., Colombetti, P., Colonna, N., Camprini, P. Console, Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Dellmann, S., Di Castro, M., Di Maria, S., Diakaki, M., Dietz, M., Dressler, R., Dupont, E., Durán, I., Eleme, Z., Fargier, S., Fernández, B., Fernández-Domínguez, B., Finocchiaro, P., Fiore, S., Furman, V., García-Infantes, F., Gawlik-Ramikega, A., Gervino, G., Gilardoni, S., Guerrero, C., Gunsing, F., Gustavino, C., Heyse, J., Hillman, W., Jenkins, D. G., Jericha, E., Junghans, A., Kadi, Y., Kaperoni, K., Kaur, G., Kimura, A., Knapová, I., Kokkoris, M., Kopatch, Y., Krtička, M., Kyritsis, N., Lederer-Woods, C., Lerner, G., Manna, A., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Maugeri, E. A., Mazzone, A., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Mucciola, R., Murtas, F., Musacchio-Gonzalez, E., Musumarra, A., Negret, A., Pérez-Maroto, P., Patronis, N., Pavón-Rodríguez, J. A., Pellegriti, M. G., Perkowski, J., Petrone, C., Pirovano, E., Pomp, S., Porras, I., Praena, J., Quesada, J. M., Reifarth, R., Rochman, D., Romanets, Y., Rubbia, C., Sabaté-Gilarte, M., Schillebeeckx, P., Schumann, D., Sekhar, A., Smith, A. G., Sosnin, N. V., Stamati, M. E., Sturniolo, A., Tagliente, G., Tarrío, D., Torres-Sánchez, P., Vagena, E., Variale, V., Vaz, P., Vecchio, G., Vescovi, D., Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T., Zarrella, R., and Žugec, P.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
One of the critical aspects for the accurate determination of neutron capture cross sections when combining time-of-flight and total energy detector techniques is the characterization and control of systematic uncertainties associated to the measuring devices. In this work we explore the most conspicuous effects associated to harsh count rate conditions: dead-time and pile-up effects. Both effects, when not properly treated, can lead to large systematic uncertainties and bias in the determination of neutron cross sections. In the majority of neutron capture measurements carried out at the CERN n\_TOF facility, the detectors of choice are the C$_{6}$D$_{6}$ liquid-based either in form of large-volume cells or recently commissioned sTED detector array, consisting of much smaller-volume modules. To account for the aforementioned effects, we introduce a Monte Carlo model for these detectors mimicking harsh count rate conditions similar to those happening at the CERN n\_TOF 20~m fligth path vertical measuring station. The model parameters are extracted by comparison with the experimental data taken at the same facility during 2022 experimental campaign. We propose a novel methodology to consider both, dead-time and pile-up effects simultaneously for these fast detectors and check the applicability to experimental data from $^{197}$Au($n$,$\gamma$), including the saturated 4.9~eV resonance which is an important component of normalization for neutron cross section measurements.
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- 2023
70. Energy deposition studies for the Upgrade II of LHCb at the CERN Large Hadron Collider
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Ciccotelli, Alessia, Appleby, Robert B., Cerutti, Francesco, Buffet, Kevin, Butin, Francois, Corti, Gloria, Esposito, Luigi Salvatore, Alia, Ruben Garcia, Karacson, Matthias, Lerner, Giuseppe, Prelipcean, Daniel, and Wehrle, Maud
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High Energy Physics - Experiment ,Physics - Accelerator Physics - Abstract
The Upgrade II of the LHCb experiment is proposed to be installed during the CERN Long Shutdown 4, aiming to operate LHCb at 1.5x$10^{34}cm^{-2}s^{-1}$ that is 75 times its design luminosity and reaching an integrated luminosity of about $400 fb^{-1}$ by the end of the High Luminosity LHC era. This increase of the data sample at LHCb is an unprecedented opportunity for heavy flavour physics measurements. A first upgrade of LHCb, completed in 2022, has already implemented important changes of the LHCb detector and, for the Upgrade II, further detector improvements are being considered. Such a luminosity increase will have an impact not only on the LHCb detector but also on the LHC magnets, cryogenics and electronic equipment placed in the IR8. In fact, the LHCb experiment was conceived to work at a much lower luminosity than ATLAS and CMS, implying minor requirements for protection of the LHC elements from the collision debris and therefore a different layout around the interaction point. The luminosity target proposed for the Upgrade II requires to review the layout of the entire insertion region in order to ensure safe operation of the LHC magnets and to mitigate the risk of failure of the electronic devices. The objective of this paper is to provide an overview of the implications of the Upgrade II of LHCb in the experimental cavern and in the tunnel with a focus on the LHCb detector, electronic devices and accelerator magnets.
- Published
- 2023
71. On the sharpness of some quantitative Muckenhoupt-Wheeden inequalities
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Lerner, Andrei, Li, Kangwei, Ombrosi, Sheldy, and Rivera-Ríos, Israel P.
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Mathematics - Classical Analysis and ODEs ,Mathematics - Functional Analysis - Abstract
In a recent work by Cruz-Uribe et al. was obtained that \[|\{x\in{\mathbb{R}^d}:w(x)|G(fw^{-1})(x)|>\alpha\}|\lesssim\frac{[w]_{A_1}^2}{\alpha}\int_{{\mathbb{R}^d}}|f|dx\] both in the matrix and scalar settings, where $G$ is either the Hardy-Littlewood maximal function or any Calder\'on-Zygmund operator. In this note we show that the quadratic dependence on $[w]_{A_1}$ is sharp. This is done by constructing a sequence of scalar-valued weights with blowing up characteristics so that the corresponding bounds for the Hilbert transform and maximal function are exactly quadratic., Comment: 8 pages, 3 figures. Introduction and title changed after referee's report. Main results remain the same. To appear in Comptes Rendus Math\'ematique
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- 2023
72. Auxetic Granular Metamaterials
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Haver, Daan, Acuña, Daniel, Janbaz, Shahram, Lerner, Edan, Düring, Gustavo, and Coulais, Corentin
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Condensed Matter - Soft Condensed Matter ,Condensed Matter - Materials Science ,Physics - Applied Physics - Abstract
The flowing, jamming and avalanche behavior of granular materials is satisfyingly universal and vexingly hard to tune: a granular flow is typically intermittent and will irremediably jam if too confined. Here, we show that granular metamaterials made from particles with a negative Poisson's ratio yield more easily and flow more smoothly than ordinary granular materials. We first create a collection of auxetic grains based on a re-entrant mechanism and show that each grain exhibits a negative Poisson's ratio regardless of the direction of compression. Interestingly, we find that the elastic and yielding properties are governed by the high compressibility of granular metamaterials: at a given confinement they exhibit lower shear modulus, lower yield stress and more frequent, smaller avalanches than materials made from ordinary grains. We further demonstrate that granular metamaterials promote flow in more complex confined geometries, such as intruder and hopper geometries, even when the packing contains only a fraction of auxetic grains. Our findings blur the boundary between complex fluids and metamaterials and could help in scenarios that involve process, transport and reconfiguration of granular materials.
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- 2023
73. 'It's a Fair Game', or Is It? Examining How Users Navigate Disclosure Risks and Benefits When Using LLM-Based Conversational Agents
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Zhang, Zhiping, Jia, Michelle, Lee, Hao-Ping, Yao, Bingsheng, Das, Sauvik, Lerner, Ada, Wang, Dakuo, and Li, Tianshi
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Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Cryptography and Security - Abstract
The widespread use of Large Language Model (LLM)-based conversational agents (CAs), especially in high-stakes domains, raises many privacy concerns. Building ethical LLM-based CAs that respect user privacy requires an in-depth understanding of the privacy risks that concern users the most. However, existing research, primarily model-centered, does not provide insight into users' perspectives. To bridge this gap, we analyzed sensitive disclosures in real-world ChatGPT conversations and conducted semi-structured interviews with 19 LLM-based CA users. We found that users are constantly faced with trade-offs between privacy, utility, and convenience when using LLM-based CAs. However, users' erroneous mental models and the dark patterns in system design limited their awareness and comprehension of the privacy risks. Additionally, the human-like interactions encouraged more sensitive disclosures, which complicated users' ability to navigate the trade-offs. We discuss practical design guidelines and the needs for paradigm shifts to protect the privacy of LLM-based CA users., Comment: 26 pages, 5 figures
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- 2023
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74. Scaling regimes and fluctuations of observables in computer glasses approaching the unjamming transition
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Giannini, Julia A., Lerner, Edan, Zamponi, Francesco, and Manning, M. Lisa
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Condensed Matter - Soft Condensed Matter - Abstract
Under decompression, disordered solids undergo an unjamming transition where they become under-coordinated and lose their structural rigidity. The mechanical and vibrational properties of these materials have been an object of theoretical, numerical, and experimental research for decades. In the study of low-coordination solids, understanding the behavior and physical interpretation of observables that diverge near the transition is of particular importance. Several such quantities are length scales ($\xi$ or $l$) that characterize the size of excitations, the decay of spatial correlations, the response to perturbations, or the effect of physical constraints in the boundary or bulk of the material. Additionally, the spatial and sample-to-sample fluctuations of macroscopic observables such as contact statistics or elastic moduli diverge approaching unjamming. Here, we discuss important connections between all of these quantities, and present numerical results that characterize the scaling properties of sample-to-sample contact and shear modulus fluctuations in ensembles of low-coordination disordered sphere packings and spring networks. Overall, we highlight three distinct scaling regimes and two crossovers in the disorder quantifiers $\chi_z$ and $\chi_\mu$ as functions of system size $N$ and proximity to unjamming $\delta z$. As we discuss, $\chi_X$ relates to the standard deviation $\sigma_X$ of the sample-to-sample distribution of the quantity $X$ (e.g. excess coordination $\delta z$ or shear modulus $\mu$) for an ensemble of systems. Importantly, $\chi_\mu$ has been linked to experimentally accessible quantities that pertain to sound attenuation and the density of vibrational states in glasses., Comment: updated after peer review
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- 2023
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75. Watching Stars in Pixels: The Interplay of Traffic Shaping and YouTube Streaming QoE over GEO Satellite Networks
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Liu, Jiamo, Lerner, David, Chung, Jae, Paul, Udit, Gupta, Arpit, and Belding, Elizabeth
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Computer Science - Networking and Internet Architecture - Abstract
Geosynchronous satellite (GEO) networks are a crucial option for users beyond terrestrial connectivity. However, unlike terrestrial networks, GEO networks exhibit high latency and deploy TCP proxies and traffic shapers. The deployment of proxies effectively mitigates the impact of high network latency in GEO networks, while traffic shapers help realize customer-controlled data-saver options that optimize data usage. It is unclear how the interplay between GEO networks' high latency, TCP proxies, and traffic-shaping policies affects the quality of experience (QoE) for commonly used video applications. To fill this gap, we analyze the quality of over $2$k YouTube video sessions streamed across a production GEO network with a $900$Kbps shaping rate. Given the average bit rates for the selected videos, we expected seamless streaming at $360$p or lower resolutions. However, our analysis reveals that this is not the case: $28\%$ of TCP sessions and $18\%$ of gQUIC sessions experience rebuffering events, while the median average resolution is only $380$p for TCP and $299$p for gQUIC. Our analysis identifies two key factors contributing to sub-optimal performance: (i)unlike TCP, gQUIC only utilizes $63\%$ of network capacity; and (ii)YouTube's imperfect chunk request pipelining. As a result of our study, the partner GEO ISP discontinued support for the low-bandwidth data-saving option in U.S. business and residential markets to avoid potential degradation of video quality -- highlighting the practical significance of our findings.
- Published
- 2023
76. Increasing Contributions of Temperature-Dependent Oxygenated Organic Aerosol to Summertime Particulate Matter in New York City.
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Hass-Mitchell, Tori, Joo, Taekyu, Rogers, Mitchell, Nault, Benjamin, Soong, Catelynn, Tran, Mia, Seo, Minguk, Machesky, Jo, Canagaratna, Manjula, Roscioli, Joseph, Claflin, Megan, Lerner, Brian, Blomdahl, Daniel, Misztal, Pawel, Ng, Nga, Dillner, Ann, Bahreini, Roya, Russell, Armistead, Krechmer, Jordan, Lambe, Andrew, and Gentner, Drew
- Abstract
As part of the summer 2022 NYC-METS (New York City metropolitan Measurements of Emissions and TransformationS) campaign and the ASCENT (Atmospheric Science and Chemistry mEasurement NeTwork) observational network, speciated particulate matter was measured in real time in Manhattan and Queens, NY, with additional gas-phase measurements. Largely due to observed reductions in inorganic sulfate aerosol components over the 21st century, summertime aerosol composition in NYC has become predominantly organic (80-83%). Organic aerosol source apportionment via positive matrix factorization showed that this is dominated by secondary production as oxygenated organic aerosol (OOA) source factors comprised 73-76% of OA. Primary factors, including cooking-related organic aerosol (COA) and hydrocarbon-like organic aerosol (HOA) comprised minor fractions of OA, only 13-15% and 10-11%, respectively. The two sites presented considerable spatiotemporal variations in OA source factor concentrations despite similar average PM2.5 concentrations. The less- and more-oxidized OOA factors exhibited clear temperature dependences at both sites with increased concentrations and greater degrees of oxidation at higher temperatures, including during a heatwave. With strong temperature sensitivity and minimal changes in summertime concentrations since 2001, secondary OA poses a particular challenge for air quality policy in NYC that will very likely be exacerbated by continued climate change and extreme heat events.
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- 2024
77. Spatiotemporal characteristics of neurophysiological changes in patients with four‐repeat tauopathies
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Samudra, Niyatee, Lerner, Hannah, Yack, Leslie, Walsh, Christine M, Kirsch, Heidi E, Kudo, Kiwamu, Yballa, Claire, La Joie, Renaud, Gorno‐Tempini, Maria L, Spina, Salvatore, Seeley, William W, Neylan, Thomas C, Miller, Bruce L, Rabinovici, Gil D, Boxer, Adam, Grinberg, Lea T, Rankin, Katherine P, Nagarajan, Srikantan S, and Ranasinghe, Kamalini G
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Acquired Cognitive Impairment ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Rare Diseases ,Brain Disorders ,Pick's Disease ,Neurodegenerative ,Dementia ,Neurosciences ,Alzheimer's Disease ,Frontotemporal Dementia (FTD) ,Aging ,Alzheimer's Disease Related Dementias (ADRD) ,2.1 Biological and endogenous factors ,Neurological ,Humans ,tau Proteins ,Tauopathies ,Alzheimer Disease ,Supranuclear Palsy ,Progressive ,Brain ,Clinical Sciences ,Clinical and health psychology - Abstract
IntroductionProgressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), are the most common four-repeat tauopathies (4RT), and both frequently occur with varying degree of Alzheimer's disease (AD) copathology. Intriguingly, patients with 4RT and patients with AD are at opposite ends of the wakefulness spectrum-AD showing reduced wakefulness and excessive sleepiness whereas 4RT showing decreased homeostatic sleep. The neural mechanisms underlying these distinct phenotypes in the comorbid condition of 4RT and AD are unknown. The objective of the current study was to define the alpha oscillatory spectrum, which is prominent in the awake resting-state in the human brain, in patients with primary 4RT, and how it is modified in comorbid AD-pathology.MethodIn an autopsy-confirmed case series of 4R-tauopathy patients (n = 10), whose primary neuropathological diagnosis was either PSP (n = 7) or CBD (n = 3), using high spatiotemporal resolution magnetoencephalography (MEG), we quantified the spectral power density within alpha-band (8-12 Hz) and examined how this pattern was modified in increasing AD-copathology. For each patient, their regional alpha power was compared to an age-matched normative control cohort (n = 35).ResultPatients with 4RT showed increased alpha power but in the presence of AD-copathology alpha power was reduced.ConclusionsAlpha power increase in PSP-tauopathy and reduction in the presence of AD-tauopathy is consistent with the observation that neurons activating wakefulness-promoting systems are preserved in PSP but degenerated in AD. These results highlight the selectively vulnerable impacts in 4RT versus AD-tauopathy that may have translational significance on disease-modifying therapies for specific proteinopathies.
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- 2024
78. Predictors of direct oral anticoagulant concentrations in the trauma population.
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Perkins, Louis, Adams, Laura, Lerner, Dmitri, Santorelli, Jarrett, Smith, Alan, and Kobayashi, Leslie
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Anticoagulants ,blood coagulation tests ,critical care - Abstract
INTRODUCTION: Direct oral anticoagulant (DOAC) use is becoming more prevalent in patients presenting after trauma. We sought to identify the prevalence and predictors of subtherapeutic and therapeutic DOAC concentrations and hypothesized that increased anti-Xa levels would correlate with increased risk of bleeding and other poor outcomes. METHODS: A retrospective cohort study of all trauma patients on apixaban or rivaroxaban admitted to a level 1 trauma center between January 2015 and July 2021 was performed. Patients were excluded if they did not have a DOAC-specific anti-Xa level at presentation. Therapeutic levels were defined as an anti-Xa of 50 ng/mL to 250 ng/mL for rivaroxaban and 75 ng/mL to 250 ng/mL for apixaban. Linear regression was used to identify correlations between study variables and anti-Xa level, and binomial logistic regression was used to test the association of anti-Xa level with outcomes. RESULTS: There were 364 trauma patients admitted during the study period who were documented to be on apixaban or rivaroxaban. Of these, 245 patients had anti-Xa levels measured at admission. The population was 53% woman, with median age of 78 years, and median Injury Severity Score of 5. In total, 39% of patients had therapeutic and 20% had supratherapeutic anti-Xa levels. Female sex, increased age, decreased height and weight, and lower estimated creatinine clearance were associated with higher anti-Xa levels at admission. There was no correlation between anti-Xa level and the need for transfusion or reversal agent administration, admission diagnosis of intracranial hemorrhage (ICH), progression of ICH, hospital length of stay, or mortality. CONCLUSIONS: Anti-Xa levels in trauma patients on DOACs vary widely; female patients who are older, smaller, and have decreased kidney function present with higher DOAC-specific anti-Xa levels after trauma. We were unable to detect an association between anti-Xa levels and clinical outcomes. LEVEL OF EVIDENCE: III-Prognostic and Epidemiological.
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- 2024
79. Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer’s disease
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Verma, Parul, Ranasinghe, Kamalini, Prasad, Janani, Cai, Chang, Xie, Xihe, Lerner, Hannah, Mizuiri, Danielle, Miller, Bruce, Rankin, Katherine, Vossel, Keith, Cheung, Steven W, Nagarajan, Srikantan S, and Raj, Ashish
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Biomedical and Clinical Sciences ,Neurosciences ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Alzheimer's Disease ,Brain Disorders ,Acquired Cognitive Impairment ,Dementia ,Aging ,Biomedical Imaging ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Mental health ,Humans ,Middle Aged ,Aged ,Alzheimer Disease ,Cognition Disorders ,Cognitive Dysfunction ,Brain ,Cognition ,Brain activity ,Alzheimer's disease ,Magnetoencephalography ,Spectral graph theory ,Cognitive decline ,Alzheimer’s disease ,Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundAlzheimer's disease (AD) is the most common form of dementia, progressively impairing cognitive abilities. While neuroimaging studies have revealed functional abnormalities in AD, how these relate to aberrant neuronal circuit mechanisms remains unclear. Using magnetoencephalography imaging we documented abnormal local neural synchrony patterns in patients with AD. To identify global abnormal biophysical mechanisms underlying the spatial and spectral electrophysiological patterns in AD, we estimated the parameters of a biophysical spectral graph model (SGM).MethodsSGM is an analytic neural mass model that describes how long-range fiber projections in the brain mediate the excitatory and inhibitory activity of local neuronal subpopulations. Unlike other coupled neuronal mass models, the SGM is linear, available in closed-form, and parameterized by a small set of biophysical interpretable global parameters. This facilitates their rapid and unambiguous inference which we performed here on a well-characterized clinical population of patients with AD (N = 88, age = 62.73 +/- 8.64 years) and a cohort of age-matched controls (N = 88, age = 65.07 +/- 9.92 years).ResultsPatients with AD showed significantly elevated long-range excitatory neuronal time scales, local excitatory neuronal time scales and local inhibitory neural synaptic strength. The long-range excitatory time scale had a larger effect size, compared to local excitatory time scale and inhibitory synaptic strength and contributed highest for the accurate classification of patients with AD from controls. Furthermore, increased long-range time scale was associated with greater deficits in global cognition.ConclusionsThese results demonstrate that long-range excitatory time scale of neuronal activity, despite being a global measure, is a key determinant in the local spectral signatures and cognition in the human brain, and how it might be a parsimonious factor underlying altered neuronal activity in AD. Our findings provide new insights into mechanistic links between abnormal local spectral signatures and global connectivity measures in AD.
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- 2024
80. Visible Borders, Invisible Economies: Living Death in Latinx Narratives by Kristy L. Ulibarri (review)
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Lerner, David
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- 2024
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81. Measuring Youth Perceptions of Being Known and Loved and Positive Youth Development: Cross-National Findings from Rwanda and El Salvador
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Tirrell, Jonathan M., Dowling, Elizabeth M., Kibbedi, Patience, Namurinda, Emmanuel, Iraheta, Guillermo, Dennis, Julia, Malvese, Katelyn, Abbasi-Asl, Roya, Williams, Kate, Lerner, Jacqueline V., King, Pamela Ebstyne, Sim, Alistair T. R., and Lerner, Richard M.
- Abstract
Background: Dynamic, relational developmental systems-based models of development emphasize that developmentally-nurturant youth-adult relationships elicit in youth perceptions of being known and loved. Although such perceptions are foundations of positive youth development (PYD), such measures do not exist. Objective: We sought to create a theoretically-predicated measure of youth perceptions of being known and loved by capitalizing on data sets in two countries (Rwanda and El Salvador) wherein a multi-national study of PYD was being conducted by Compassion International (CI). Method: With Rwanda data (n = 1,204, M[subscript age] = 11.84, 50% CI-supported), exploratory and confirmatory factor analyses enabled refining the measure for robustness and parsimony. Measures of intentional self-regulation, hopeful future expectations, transcendence, and contribution were used for validation of the known and loved measure within the nomological net of constructs proposed in the Lerner and Lerner PYD model. Confirmatory factor analyses supported the use of the model within the El Salvador data set (n = 1,205, M[subscript age] = 13.03, 51% CI-supported). Results: Robust psychometric properties were established in both national settings. Measurement invariance was found across age, gender, urban--rural location, CI-enrollment status, and nations, and involved both mean differences and correlations among latent factors. Conclusions: The results provide evidence for a theory-predicated measure of youth perceptions of being known and loved and that scores for this construct covary within a nomological net specified in the Lerner and Lerner model of PYD. These findings serve international development organizations seeking theory-predicated measures for use in evaluating PYD programs in low- and middle-income countries.
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- 2023
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82. From Taylor Swift to MLK: Understanding Adolescents' Famous Character Role Models
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Alison B. Hammond, Sara K. Johnson, Michelle B. Weiner, and Jacqueline V. Lerner
- Abstract
Famous people can positively influence young people by serving as examples of how to be a good person, but very little is known about which famous people youth look up to and why they do so. We coded and analyzed open-response data from 596 adolescents (M[subscript age] = 14.09 years; 58.5% girls, 57.5% White) in the northeastern United States to understand the types of famous people youth look up to and why they reported nominating them. Youth identified a variety of individuals as their famous character role models (FCRMs), ranging from athletes to politicians to activists and YouTube stars. The results suggest there are various reasons young people look up to FCRMs as examples of how to be a good person, although character attributes appear to be the most frequently cited reasons. Results serve as an important precursor to a more comprehensive investigation of the influence (either positive or negative) of these public figures.
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- 2024
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83. School Coaches in the United States: Insights from the National Coach Survey
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Samantha M. Bates, Vincent F. Minjares, Dawn Anderson-Butcher, Jennifer Brown Lerner, and Jon Solomon
- Abstract
Concerns exist about how the landscape of school sports is changing, leaving many school coaches feeling unprepared to meet the challenges of this role today. This article explores the status of school sports coaching by drawing on recent findings from the National Coach Survey, the first-of-its-kind survey in the United States released in 2022.
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- 2024
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84. Vocal Emotion Recognition in Autism: Behavioral Performance and Event-Related Potential (ERP) Response
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Talena C. Day, Isha Malik, Sydney Boateng, Kathryn M. Hauschild, and Matthew D. Lerner
- Abstract
Autistic youth display difficulties in emotion recognition, yet little research has examined behavioral and neural indices of vocal emotion recognition (VER). The current study examines behavioral and event-related potential (N100, P200, Late Positive Potential [LPP]) indices of VER in autistic and non-autistic youth. Participants (N = 164) completed an emotion recognition task, the Diagnostic Analyses of Nonverbal Accuracy (DANVA-2) which included VER, during EEG recording. The LPP amplitude was larger in response to high intensity VER, and social cognition predicted VER errors. Verbal IQ, not autism, was related to VER errors. An interaction between VER intensity and social communication impairments revealed these impairments were related to larger LPP amplitudes during low intensity VER. Taken together, differences in VER may be due to higher order cognitive processes, not basic, early perception (N100, P200), and verbal cognitive abilities may underlie behavioral, yet occlude neural, differences in VER processing.
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- 2024
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85. In Pursuit of Campus-Wide Data Literacy: A Guide to Developing a Statistics Course for Students in Nonquantitative Fields
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Alexis Lerner and Andrew Gelman
- Abstract
Data literacy for students in nonquantitative fields is important as statistics become the grammar of research and how the world's decisions are made. Statistics courses are typically offered by mathematics or statistics departments or by social and natural sciences such as economics, political science, psychology, and biology. Here we discuss how to construct a statistics course for students in nonquantitative fields, with a goal of integrating statistical material with students' substantive interests, using student-focused teaching methods and technology to increase student involvement. We demonstrate this kind of hybrid course with the example of an introductory applied statistics class, taught at both the University of Toronto's Anne Tanenbaum Center for Jewish Studies and the United States Naval Academy.
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- 2024
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86. The Apple Doesn't Fall Far from the Tree: Longitudinal Associations among American Adolescents' Civic Engagement and Family and School Characteristics
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Trang U. Le, Sara K. Johnson, and Jacqueline V. Lerner
- Abstract
Adolescents' civic engagement is related to other aspects of their positive development. Many family and school characteristics can promote adolescents' civic engagement, but they are often studied separately. Furthermore, studies have often used adolescent self-reports and measured only one aspect of the multidimensional construct of civic engagement. Using longitudinal, multi-rater data from 539 adolescents (59.4% girls, 56.8% White) and 356 parents (80% mothers), we examined family and school characteristics that promote adolescents' social responsibility and five civic actions. Structural equation models showed that parents' social responsibility and civic actions predicted adolescents' corresponding civic outcomes six months later. Extracurricular opportunities in school predicted adolescents' community service and helping behaviors. Open classroom climate predicted adolescents' helping behaviors and moderated the association between parents' and adolescents' social responsibility. Parental warmth and classroom discussion of social issues did not predict adolescents' civic engagement. We discuss limitations, implications, and directions for future research.
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- 2024
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87. On the hard edge limit of the zero temperature Laguerre beta corners process
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Lerner-Brecher, Matthew
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Mathematics - Probability ,60B20, 60G15, 34B24 - Abstract
We study the hard edge limit of a multilevel extension of the Laguerre $\beta$-ensemble at zero temperature. In particular, we show that asymptotically the ensemble is given by Gaussians with covariance matrix expressible in terms of the Fourier-Bessel series. These Gaussians also have an explicit representation as the partition functions of additive polymers arising from a random walk on roots of the Bessel functions. Our approach builds off of the one introduced in arxiv:2009.02006 and is rooted in using the theory of dual and associated polynomials to diagonalize transition matrices relating levels of the ensemble., Comment: 36 pages, 1 figure
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- 2023
88. Relational hyperevent models for the coevolution of coauthoring and citation networks
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Lerner, Jürgen, Hâncean, Marian-Gabriel, and Lomi, Alessandro
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Computer Science - Digital Libraries ,Statistics - Applications - Abstract
The development of suitable statistical models for the analysis of bibliographic networks has trailed behind the empirical ambitions expressed by recent studies of science of science. Extant research typically restricts the analytical focus to either paper citation networks, or author collaboration networks. These networks involve not only direct relationships between papers or authors, but also a broader system of dependencies between the references of papers connected through multiple simultaneous citation links. In this work, we extend recently developed relational hyperevent models (RHEM) to analyze scientific networks - systems of scientific publications connected by citations and authorship. We introduce new covariates that represent theoretically relevant and empirically meaningful sub-network configurations. The new model specification supports testing of hypotheses that align with the polyadic nature of scientific publication events and the multiple interdependencies between authors and references of current and prior papers. We implement the model using open-source software to analyze a large, publicly available scientific network dataset. A significant finding of the study is the tendency for subsets of papers to be repeatedly cited together across publications. This result is crucial as it suggests that the papers' impact may be partly due to endogenous network processes. More broadly, the study shows that models accounting for both the hyperedge structure of publication events and the interconnections between authors and references significantly enhance our understanding of the network mechanisms that drive scientific production, productivity, and impact., Comment: Preprint of a submitted manuscript
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- 2023
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89. Resonant fractional conductance through a 1D Wigner chain
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Davies, Rose, Lerner, Igor V., and Yurkevich, Igor V.
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Condensed Matter - Strongly Correlated Electrons - Abstract
In recent experiments on conductance of one-dimensional (1D) channels in ultra-clean samples, a diverse set of plateaus were found at fractions of the quantum of conductance in zero magnetic field. We consider a discrete model of strongly interacting electrons in a clean 1D system where the current between weak tunneling contacts is carried by fractionally charged solutions. While in the spinless case conductance remains unaffected by the interaction, as is typical for the strongly interacting clean 1D systems, we demonstrate that in the spinful case the peak conductance takes fractional values that depend on the filling factor of the 1D channel., Comment: 5 pages, 3 figures
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- 2023
90. Bounded Bessel Processes and Ferrari-Spohn Diffusions
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Lerner-Brecher, Matthew
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Mathematics - Probability ,60J60, 34B24 - Abstract
We introduce a new diffusion process which arises as the $n\to\infty$ limit of a Bessel process of dimension $d \ge 2$ conditioned upon remaining bounded below one until time $n$. In addition to being interesting in its own right, we argue that the resulting diffusion process is a natural hard edge counterpart to the Ferrari-Spohn diffusion of arXiv:math/0308242. In particular, we show that the generator of our new diffusion has the same relation to the Sturm-Liouville problem for the Bessel operator that the Ferrari-Spohn diffusion does to the corresponding problem for the Airy operator., Comment: 8 pages
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- 2023
91. Bloom weighted bounds for sparse forms associated to commutators
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Lerner, Andrei K., Lorist, Emiel, and Ombrosi, Sheldy
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Mathematics - Classical Analysis and ODEs ,42B20, 42B25, 47B47 - Abstract
In this paper we consider bilinear sparse forms intimately related to iterated commutators of a rather general class of operators. We establish Bloom weighted estimates for these forms in the full range of exponents, both in the diagonal and off-diagonal cases. As an application, we obtain new Bloom bounds for commutators of (maximal) rough homogeneous singular integrals and the Bochner-Riesz operator at the critical index. We also raise the question about the sharpness of our estimates. In particular we obtain the surprising fact that even in the case of Calder\'on--Zygmund operators, the previously known quantitative Bloom weighted estimates are not sharp for the second and higher order commutators., Comment: 34 pages
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- 2023
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92. Validating AI-Generated Code with Live Programming
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Ferdowsi, Kasra, Huang, Ruanqianqian, James, Michael B., Polikarpova, Nadia, and Lerner, Sorin
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Computer Science - Human-Computer Interaction ,Computer Science - Programming Languages - Abstract
AI-powered programming assistants are increasingly gaining popularity, with GitHub Copilot alone used by over a million developers worldwide. These tools are far from perfect, however, producing code suggestions that may be incorrect in subtle ways. As a result, developers face a new challenge: validating AI's suggestions. This paper explores whether Live Programming (LP), a continuous display of a program's runtime values, can help address this challenge. To answer this question, we built a Python editor that combines an AI-powered programming assistant with an existing LP environment. Using this environment in a between-subjects study (N=17), we found that by lowering the cost of validation by execution, LP can mitigate over- and under-reliance on AI-generated programs and reduce the cognitive load of validation for certain types of tasks., Comment: 8 pages, 4 figures
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- 2023
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93. Coulomb blockade in a non-thermalized quantum dot
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McArdle, George, Davies, Rose, Lerner, Igor V., and Yurkevich, Igor V.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Strongly Correlated Electrons - Abstract
We investigate non-equilibrium transport properties of a quantum dot in the Coulomb blockade regime under the condition of negligible inelastic scattering during the dwelling time of the electrons in the dot. Using the quantum kinetic equation we show that the absence of thermalization leads to a double-step in the distribution function of electrons on the dot, provided that it is symmetrically coupled to the leads. This drastically changes nonlinear transport through the dot resulting in an additional (compared to the thermalized case) jump in the conductance at voltages close to the charging energy, which could serve as an experimental manifestation of the absence of thermalization., Comment: 5 pages, 3 figures, and Supplemental material (4 pages); final version, as published (figures updated and revised discussion and supplemental material)
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- 2023
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94. Imaging prognostication and tumor biology in hepatocellular carcinoma.
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Kadi, Diana, Yamamoto, Marilyn, Lerner, Emily, Jiang, Hanyu, Bashir, Mustafa, and Fowler, Kathryn
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Carcinoma ,hepatocellular ,Imaging ,Prognosis ,Subtypes - Abstract
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, and represents a significant global health burden with rising incidence rates, despite a more thorough understanding of the etiology and biology of HCC, as well as advancements in diagnosis and treatment modalities. According to emerging evidence, imaging features related to tumor aggressiveness can offer relevant prognostic information, hence validation of imaging prognostic features may allow for better noninvasive outcomes prediction and inform the selection of tailored therapies, ultimately improving survival outcomes for patients with HCC.
- Published
- 2023
95. A History of Early US Pinball Sound, 1871–1939
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Lerner, Neil, Gibbons, William, book editor, and Grimshaw-Aagaard, Mark, book editor
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- 2024
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96. Trend of ambulatory benign prostatic obstruction surgeries during COVID-19 pandemic
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Qian, Zhiyu, Filipas, Dejan, Beatrici, Edoardo, Ye, Jamie, Cho, Mansoo, Dagnino, Filippo, Zurl, Hanna, Stelzl, Daniel, Friedlander, David F., Trinh, Quoc-Dien, Lipsitz, Stuart R., Cole, Alexander P., and Lerner, Lori B.
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- 2024
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97. Understanding the impact of distance and disadvantage on lung cancer care and outcomes: a study protocol
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McInnerney, Daisy, Quaife, Samantha L., Cooke, Samuel, Mitchinson, Lucy, Pogson, Zara, Ricketts, William, Januszewski, Adam, Lerner, Anna, Skinner, Dawn, Civello, Sarah, Kane, Ros, Harding-Bell, Ava, Calman, Lynn, Selby, Peter, Peake, Michael D., and Nelson, David
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- 2024
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98. Arabidopsis CaLB1 undergoes phase separation with the ESCRT protein ALIX and modulates autophagosome maturation
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Mosesso, Niccolò, Lerner, Niharika Savant, Bläske, Tobias, Groh, Felix, Maguire, Shane, Niedermeier, Marie Laura, Landwehr, Eliane, Vogel, Karin, Meergans, Konstanze, Nagel, Marie-Kristin, Drescher, Malte, Stengel, Florian, Hauser, Karin, and Isono, Erika
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- 2024
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99. Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
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Wu, Fei, Du, Huixun, Overbey, Eliah, Kim, JangKeun, Makhijani, Priya, Martin, Nicolas, Lerner, Chad A., Nguyen, Khiem, Baechle, Jordan, Valentino, Taylor R., Fuentealba, Matias, Bartleson, Juliet M., Halaweh, Heather, Winer, Shawn, Meydan, Cem, Garrett-Bakelman, Francine, Sayed, Nazish, Melov, Simon, Muratani, Masafumi, Gerencser, Akos A., Kasler, Herbert G., Beheshti, Afshin, Mason, Christopher E., Furman, David, and Winer, Daniel A.
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- 2024
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100. GREM2 inactivation increases trabecular bone mass in mice
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Nilsson, Karin H., Henning, Petra, Wu, Jianyao, Sjögren, Klara, Lerner, Ulf H., Ohlsson, Claes, and Movérare-Skrtic, Sofia
- Published
- 2024
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