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288 results on '"Leoni, O"'

75. Short-acting inhaled beta-2-agonists increased the mortality from chronic obstructive pulmonary disease in observational designs

Author

Corrao, G, Zambon, A, Faini, S, Bagnardi, V, Leoni, O, Suissa, S, CORRAO, GIOVANNI, ZAMBON, ANTONELLA, BAGNARDI, VINCENZO, Suissa, S., Corrao, G, Zambon, A, Faini, S, Bagnardi, V, Leoni, O, Suissa, S, CORRAO, GIOVANNI, ZAMBON, ANTONELLA, BAGNARDI, VINCENZO, and Suissa, S.

Abstract

OBJECTIVE: The effect of short-acting inhaled beta(2)-agonists on mortality from chronic obstructive pulmonary disease (COPD) is controversial. Different observational designs were used to investigate about this topic. STUDY DESIGN AND SETTING: A population-based case-control design was performed, by linking automated health databases from the Varese Province of Italy. Deaths of COPD generated from the cohort of 135,871 patients for whom at least one prescription for drugs used to treat COPD had been dispensed between 1997 and 1999 entered into the study as cases. Up to 20 controls were randomly selected for each case from the cohort after matching on gender, age, and date of cohort entry. Risk ratios were estimated using the case-control, case-crossover, and case-time-control approaches. RESULTS: A total of 222 cases and 3022 controls met the inclusion criteria. Odds ratios (and corresponding 95% confidence intervals) corresponding to more than 0.5 defined-daily-doses were 2.6 (1.7, 4.0), 1.9 (1.1, 3.3), 2.1 (1.1, 4.0), and 2.3 (1.2, 4.6) by using crude and adjusted case-control, case-crossover, and case-time-control estimates, respectively. CONCLUSION: Evidence that higher doses of short-acting inhaled beta(2)-agonists are associated with higher mortality from COPD was consistently supplied by three observational approaches.

Published
2005

76. Lipid lowering drugs prescription and the risk of peripheral neuropathy: an exploratory case-control study using automated databases

Author

Corrao, G, Zambon, A, Bertù, L, Botteri, E, Leoni, O, Contiero, P, CORRAO, GIOVANNI, ZAMBON, ANTONELLA, Contiero, P., Corrao, G, Zambon, A, Bertù, L, Botteri, E, Leoni, O, Contiero, P, CORRAO, GIOVANNI, ZAMBON, ANTONELLA, and Contiero, P.

Abstract

STUDY OBJECTIVE: Although lipid lowering drugs are effective in preventing morbidity and mortality from cardiovascular events, the extent of their adverse effects is not clear. This study explored the association between prescription of lipid lowering drugs and the risk of peripheral neuropathy. DESIGN: A population based case-control study was carried out by linkage of several automated databases. SETTING: Resident population of a northern Italian Province aged 40 years or more. PARTICIPANTS: Cases were patients discharged for peripheral neuropathy in 1998-1999. For each case up to 20 controls were randomly selected among those eligible. Altogether 2040 case patients and 36 041 controls were included in the study.Exposure ascertainment: Prescription drug database was used to assess exposure to lipid lowering drugs at any time in the one year period preceding the index date.Analysis: Conditional logistic regression model for matched data was used to estimate the risk of peripheral neuropathy associated with exposure to statins, fibrates, and other lipid lowering drugs. MAIN RESULTS: Weak but significant effects of lipid lowering drugs as a whole (matched odds ratio: 1.27; 95% confidence intervals 1.05 to 1.55), statins (1.19; 1.00 to 1.40), and fibrates (1.49; 1.03 to 2.17) were observed. Significant linear trends towards increased risk at increased exposure to both statins and fibrates were observed. CONCLUSIONS: The use of both statins and fibrates was associated with the risk of peripheral neuropathy. The primary purpose of this exploratory study is signal generation. This requires further investigations to evaluate the causal role of lipid lowering drugs on the onset of peripheral neuropathy.

Published
2004

97. Transfer of calibration function in near-infrared spectroscopy

Author

Forina, M., primary, Drava, G., additional, Armanino, C., additional, Boggia, R., additional, Lanteri, S., additional, Leardi, R., additional, Corti, P., additional, Conti, P., additional, Giangiacomo, R., additional, Galliena, C., additional, Bigoni, R., additional, Quartari, I., additional, Serra, C., additional, Ferri, D., additional, Leoni, O., additional, and Lazzeri, L., additional

Published
1995
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