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Objetivo: Comprobar las diferencias en la calidad de vida y la información de los pacientes con cáncer de próstata según el tratamiento y grupo de riesgo, y valorar su asociación con las variables sociodemográficas y clínicas. Metodo: entre 2015-2016, 176 hombres con cáncer de próstata seleccionados aleatoriamente, que habían recibido tratamientos locales, hormonales o combinados fueron evaluados mediante entrevista y los cuestionarios EORTC QLQ-C30, EORTC QLQ-PR25 y EORTC QLQ-INFO25. Resultados: La calidad de vida estaba más deteriorada en las escalas física, de rol, social y sexual en el grupo de riesgo avanzado y los tratados con hormonoterapia. La prostatectomía era la que producía más problemas urinarios, y los tratamientos combinados mayor sintomatología hormonal. Los tratados con radioterapia consideraban la información más útil y se sentían más informados sobre la enfermedad, pruebas médicas y tratamientos que los que recibían tratamiento hormonal y estaban más satisfechos que los intervenidos con prostatectomía. Los mayores o con estudios básicos recibieron menos información y la consideraron menos útil. Conclusiones: La calidad de vida es satisfactoria y la sintomatología baja. Los hombres en riesgo avanzado y/o los que reciben hormonoterapia presentan mayor déficit en la calidad de vida. La información es deficitaria, sobre todo en los hombres con problemas urinarios y con peor calidad de vida. Hay poca o ninguna información en las áreas “otros servicios”, “lugares de cuidado” y “pautas de autocuidado”. Es necesario evaluar y tratar a los hombres más vulnerables. Además de formar en información al personal sanitario.

Con el presente artículo, se pretende dar a conocer los tratamientos psicológicos eficaces en el cáncer de próstata que se han llevado a cabo hasta la actualidad. Para entender los tratamientos psicológicos, es importante conocer, aunque sea de manera general, qué medios médicos se llevan a cabo para curar o paliar la enfermedad y sus efectos (reversibles o irreversibles), ya que el bienestar biopsicológico influye en la calidad de vida del individuo y, en su salud física y psicológica. A pesar de que el cáncer de próstata es el cáncer más común en los hombres de nuestro país y que actualmente muchos se diagnostican en estadios iniciales, lo que aumenta la posibilidad de curación, existen pocos estudios sobre tratamientos psicológicos para afrontar este tumor, tanto a nivel nacional como internacional. Es importante seguir avanzando en la investigación, principalmente en aquella que vaya dirigida a evaluar la eficacia de los tratamientos psicológicos.

To establish consensus guidelines for a safe clinical practice of accelerated partial breast irradiation (APBI) interstitial multicatheter brachytherapy (BT). APBI with interstitial multicatheter BT has proved to be effective in the treatment of early stage breast cancer. This paradigm shift in the approach to early breast cancer conservative treatment, along with the existing controversies on the clinical practice of APBI, prompted the Spanish Brachytherapy Group (GEB) of the Spanish Societies of Radiation Oncology (SEOR) and Medical Physics (SEFM) to address BT APBI in a consensus meeting. Prior to the meeting, a survey with 27 questions on indication, inclusion criteria, BT modality, implant technique, image guidance and simulation, CTV and OAR definition, dose prescription and fractionation, dose calculation, implant quality metrics and OAR dose constrains was distributed. Items not reaching a level of agreement of 70% were discussed and voted during the meeting. 26 Institutions completed the survey, 60% of them perform APBI procedures. The analysis of the survey showed consensus reached on approximately half the questions. An expert panel discussed the remaining items; thereafter, a voting established the definite consensus. This document summarizes the consensus guidelines agreed during the meeting of the Spanish Brachytherapy Group SEOR-SEFM. Institutions with BT facilities available should offer interstitial BT APBI as a treatment option to patients fulfilling the inclusion criteria. Institutions willing to implement interstitial BT APBI are encouraged to follow the consensus guidelines established herein. [ABSTRACT FROM AUTHOR]

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Copyright of Psicooncologia is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The serial monitoring of cardiac troponin represents an effective approach for the early identification, assessment, and monitoring of chemotherapy-induced cardiac injury. Over the last few years new generations of troponin assays, referred to as sensitive and high sensitivity assays, able to detect very low concentrations of troponin, have been progressively released on different platforms. Some studies have assessed the comparability of the cTnI measurements with the new assays versus the conventional ones, but none of these in the oncological population. We compared the cTnI results determined on Stratus CS and ADVIA Centaur CP System in 70 breast cancer patients, for a total of 327 samples collected during different cycles of treatment. Correlation (Spearman = 0.732) and agreement (91.4%) between the assays were good (244 concordant negatives and 55 concordant positives), with a frequency of 8.6% discordant results among the cTnI measurements. Despite the well-known lack in the harmonization and standardization of the currently commercially available cTnI methods, we found a good clinical concordance of cTnI determination on both systems.

Background: Chronic cardiac dysfunction may develop after administration of aggressive chemotherapy, sometimes leading to development of congestive heart failure (CHF). Recently, N-terminal pro-B-type natriuretic peptide (NT-proBNP) was implicated as a marker of CHF. In this study we evaluated the predictive role of NT-proBNP in patients treated with high-dose chemotherapy (HDC)., Methods: NT-proBNP was measured after 62 chemotherapy treatments in 52 patients affected by aggressive malignancies. Blood samples were drawn before the start of HDC, at the end of HDC administration, and 12, 24, 36, and 72 h thereafter. In these patients, echocardiograms were performed regularly during a 1-year follow-up., Results: Seventeen patients (33%) had persistently increased NT-proBNP, 19 patients (36%) had only transient increases (concentrations went back to baseline at 72 h), and 16 (31%) had no increases [mean (SD) values at 72 h, 1163 (936) ng/L vs 185 (101) ng/L vs 39 (19) ng/L, respectively; P <0.0001]. Only patients with persistently increased NT-proBNP had a significant worsening of the left ventricular diastolic indexes from baseline to 12 months [ratio of peak early to peak late flow velocities from 1.42 (0.33) to 0.78 (0.11); P <0.0001; isovolumetric relaxation time from 90 (15) to 141 (26) ms; P <0.0001; E-wave deceleration time from 162 (17) to 224 (32) ms; P = 0.0004] and of the left ventricular ejection fraction [from 62.8 (3.4)% to 45.6 (11.5)%; P <0.0001]., Conclusions: Persistently increased NT-proBNP early after administration of HDC is strongly associated with development of cardiac dysfunction. This finding has important implications for identifying patients at risk of developing chemotherapy-induced cardiotoxicity.

Background: Increased cardiac troponin I (cTnI) in patients treated with high-dose chemotherapy (HDCT) for aggressive malignancy has been proposed as an early marker of late HDCT-induced cardiac dysfunction. We investigated whether cTnI measured by the Stratus CS (Dade Behring) would allow detection of minimal cTnI increases in patients treated with HDCT., Methods: Plasma cTnI concentrations were determined in 179 consecutive patients before HDCT, at the end of the treatment, and after 12, 24, 36, and 72 h. Cardiac function was explored by echocardiography, and left ventricular ejection fraction (LVEF) was recorded during follow-up. The greatest variation in LVEF from the baseline value was used as a measure of cardiac damage., Results: In 99 healthy volunteers, the 99th percentile was at 0.07 microg/L. On the basis of ROC curve analysis (area under the curve, 0.89), a cutoff of 0.08 microg/L was chosen (sensitivity, 82%; specificity, 77%). cTnI > or =0.08 microg/L occurred in 57 patients (32%) with echocardiographic monitoring revealing a mean decrease in LVEF of 18%. In comparison, the group of cTnI-negative patients had a mean decrease in LVEF of 2.5% (P <0.001)., Conclusions: Plasma cTnI, as measured with the Stratus CS, can detect minor myocardial injury in patients treated with HDCT.