51. Nasopharyngeal pneumococcal density is associated with viral activity but not with use of improved stoves among young Andean children
- Author
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Carlos G. Grijalva, Leigh M Howard, John V. Williams, Yuwei Zhu, Marie R. Griffin, Ana I. Gil, Stella M. Hartinger, Jorge E. Vidal, Kathryn M. Edwards, Keith P. Klugman, Roger R. Fan, and Claudio F. Lanata
- Subjects
0301 basic medicine ,030106 microbiology ,purl.org/pe-repo/ocde/ford#3.03.08 [https] ,Improved stoves ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,indoor smoke exposure ,respiratory viruses ,Major Article ,Medicine ,Colonization ,030212 general & internal medicine ,Respiratory tract infections ,business.industry ,Antibiotic exposure ,3. Good health ,Infectious Diseases ,Oncology ,pneumococcal density ,Viral Activity ,Respiratory virus ,Sample collection ,business ,pneumococcus ,Demography - Abstract
Background Indoor smoke exposure is common in developing countries and may influence nasopharyngeal (NP) pneumococcal colonization density and risk of acute respiratory illness. We compared colonization density among Andean children living in households previously enrolled in a randomized controlled trial of a home intervention package including improved stoves to reduce smoke, kitchen sinks, and water disinfection. Methods We enrolled 260 children aged Results Age and sociodemographic characteristics were similar between groups. Although no differences were observed in densities between groups, colonization density varied significantly over time in both groups, with highest densities coinciding with spring months. Time during and after virus-associated ARI was also associated with higher pneumococcal colonization density than time remote from ARIs. Conclusions A home intervention package, including improved stoves, was not associated with changes in pneumococcal densities in young Andean children. However, increasing pneumococcal density was observed with spring season and viral-associated ARIs.
- Published
- 2017