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1,733 results on '"Lehn J"'

53. Strain-induced reactivity in the dynamic covalent chemistry of macrocyclic imines

Author

Ratjen, L., Vantomme, G., Lehn, J.-M., and Publica

Abstract

The displacement of molecular structures from their thermodynamically most stable state by imposition of various types of electronic and conformational constraints generates highly strained entities that tend to release the accumulated strain energy by undergoing either structural changes or chemical reactions. The latter case amounts to strain-induced reactivity (SIR) that may enforce specific chemical transformations. A particular case concerns dynamic covalent chemistry which may present SIR, whereby reversible reactions are activated by coupling to a high-energy state. We herewith describe such a dynamic covalent chemical (DCC) system involving the reversible imine formation reaction. It is based on the formation of strained macrocyclic bis-imine metal complexes in which the macrocyclic ligand is in a high energy form enforced by the coordination of the metal cation. Subsequent demetallation generates a highly strained free macrocycle that releases its accumulated s train energy by hydrolysis and reassembly into a resting state. Specifically, the metal-templated condensation of a dialdehyde with a linear diamine leads to a bis-imine [1+1]-macrocyclic complex in which the macrocyclic ligand is in a coordination-enforced strained conformation. Removal of the metal cation by a competing ligand yields a highly reactive [1+1]-macrocycle, which then undergoes hydrolysis to transient non-cyclic aminoaldehyde species, which then recondense to a strain-free [2+2]-macrocyclic resting state. The process can be monitored by 1H NMR spectroscopy. Energy differences between different conformational states have been evaluated by Hartree-Fock (HF) computations. One may note that the stabilisation of high-energy molecular forms by metal ion coordination followed by removal of the latter, offers a general procedure for producing out-of-equilibrium molecular states, the fate of which may then be examined, in particular when coupled to dynamic covalent chemical processes.

Published
2015

54. Antihypoxic potentiation of standard therapy for experimental colorectal liver metastasis through myo-inositol trispyrophosphate

Author

Limani, P, Linecker, M, Kachaylo, E, Tschuor, C, Kron, P, Schlegel, A, Ungethuem, U, Jang, J H, Georgiopoulou, S, Claude Nicolau, C, Lehn, J-M, Graf, R, Humar, B, Clavien, P-A, Limani, P, Linecker, M, Kachaylo, E, Tschuor, C, Kron, P, Schlegel, A, Ungethuem, U, Jang, J H, Georgiopoulou, S, Claude Nicolau, C, Lehn, J-M, Graf, R, Humar, B, and Clavien, P-A

Abstract

PURPOSE: Tumor hypoxia activates hypoxia-inducible factors (Hifs), which induce a range of malignant changes including vascular abnormalities. Here, we determine whether inhibition of the hypoxic tumor response through myo-inositol trispyrophosphate (ITPP), a compound with antihypoxic properties, is able to cause prolonged vascular normalization that can be exploited to improve standard-of-care treatment. EXPERIMENTAL DESIGN: We tested ITPP on two syngeneic orthotopic mouse models of lethal colorectal cancer liver metastasis. Tumors were monitored by MRI and analyzed for the hypoxic response and their malignant potential. A Hif activator and in vitro assays were used to define the working mode of ITPP. Hypoxic response and vasculature were re-evaluated 4 weeks after treatment. Finally, we determined survival following ITPP monotherapy, FOLFOX monotherapy, FOLFOX plus Vegf antibody, and FOLFOX plus ITPP, both overlapping and sequential. RESULTS: ITPP reduced tumor load, efficiently inhibited the hypoxic response, and improved survival. These effects were lost when mice were pretreated with a Hif activator. Its immediate effects on the hypoxic response, including an apparent normalization of tumor vasculature, persisted for at least 4 weeks after treatment cessation. Compared with FOLFOX alone, Vegf antibody combined with FOLFOX prolonged survival by <30%, whereas ITPP combined with FOLFOX extended survival by >140%, regardless of whether FOLFOX was given in overlap or after ITPP exposure. CONCLUSIONS: Our findings reveal a truly antihypoxic mechanism for ITPP and demonstrate the capacity of this nontoxic compound to potentiate the efficacy of existing anticancer treatment in a way amenable to clinical translation. Clin Cancer Res; 22(23); 5887-97.

Published
2016

56. Reversible photo-, metallo- and thermo-induced morphological dynamics of bis-acylhydrazones

Author

Ratjen, L., Lehn, J.-M., and Publica

Abstract

A reversible interconversion-cycle, making use of the multiple dynamic properties of bisacylhydrazones, is presented. It features photo-, metallo- and thermo-induced configurational and conformational changes and involves reversible cation binding and release, which is of potential interest for photo-induced metal signal generation or catalysis.

Published
2014

69. Generation of Functional Nanostructures - The Self-Organization Approach

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Bertrand, Annia, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

70. Annual Summer School, SoMaS School 2012, Dynamic Materials towards Functional Adaptive Materials

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Bertrand, Annia, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

71. Queen's University, Chemistry Department, From Supramolecular Chemistry towards Adaptive Chemistry

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Bertrand, Annia, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and Collège de France (CdF (institution))

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

72. The Cocker Lecture in Chemistry 2012, Trinity College, From Matter to Life : Chemistry ? Chemistry!

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Bertrand, Annia, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

73. Journées Grignard, Perspectives in Chemistry : From Supramolecular Chemistry towards Adaptive Chemistry

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Bertrand, Annia

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

74. Le Grand Débat entre Prix Nobel Par Delà les Frontières, la Science

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

75. ' Jornades Doctorals Lecture ', Perspectives in Chemistry : From Supramolecular Chemistry towards Adaptive Chemistry

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Bertrand, Annia, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and Collège de France (CdF (institution))

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

76. Association Française pour l'Information Scientifique, De la Matière à la Vie : Chimie ? Chimie !

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), and Bertrand, Annia

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

77. Institut Ruđer Bošković, Perspectives in Chemistry: From Supramolecular Chemistry towards Adaptive Chemistry

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Bertrand, Annia, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

78. De la Matière à la Vie: Chimie? Chimie !

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Bertrand, Annia, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and Collège de France (CdF (institution))

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

79. International Beilstein Symposium, Molecular Engineering and Control, Prien (Chiemsee) Steps towards Self-Organisation: From Supramolecular Chemistry to Adaptive Chemistry

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Bertrand, Annia

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

80. Siegfried-Hünig-Vorlesung 2012, Julius-Maximilians-Universität Würzburg Perspectives in Chemistry: From Supramolecular Chemistry towards Adaptive Chemistry

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Bertrand, Annia, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

81. Challenges and Prospects of Polymer Chemistry Dynamers: Dynamic Molecular and Supramolecular Polymers

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Bertrand, Annia

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

82. BioVision Alexandria 2012, Bibliotheca Alexandrina Science's Quest for a Betther Future. Some Reflections (by video)

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Bertrand, Annia, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

83. 4th International Conference on Drug Discovery & Therapy, Dubai (Émirats arabes unis) From Supramolecular Chemistry towards Adaptive Chemistry Biorganic and Drug Discovery Aspects

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

84. Department of Chemistry, Maharaja Sayajirao III University of Baroda, Perspectives in Chemistry: towards Adaptive Chemistry

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Bertrand, Annia, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and Collège de France (CdF (institution))

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

85. Baroda Lions School, Vadodara (Inde), 9 février 2012, From Matter to Life: Chemistry? Chemistry!

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Bertrand, Annia

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

86. Perspectives in Chemistry: from Supramolecular Chemistry towards Adaptive Chemistry; Dynamic Nanostructures and Materials

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Bertrand, Annia, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

87. 20 Jahre Förderverein Chemie-Olympiade Der Weg zur Komplexen Materie: Chemie? Chemie!

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Bertrand, Annia

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

88. XLAB Science Festival 2012 Von der Materie zum Leben: Chemie? Chemie!

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Bertrand, Annia

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

89. Perspectives en Chimie : De la Chimie Supramoléculaire à la Chimie Adaptative

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), Bertrand, Annia, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

90. Festakt 2012, Life Science Lab Von der Materie zaum Leben: Chemie? Chemie!

Author

Lehn, J.-M., Bertrand, Annia, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

91. 'Supramolecular chemistry: From molecular information toward self-organization and complex matter'

Author

Lehn, J.-M., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), and Bertrand, Annia

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

92. International Conference on Molecular Crowding 2012 Perspectives in Chemistry: From Supramolecular Chemistry towards Adaptive Chemistry

Author

Lehn, J.-M., Bertrand, Annia, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

94. 'Paromomycin and neomycin B derived cationic lipids: Synthesis and transfection studies', Journal of Controlled Release, 158, 461-469, 2012

Author

Mével, M., Sainlos, M., Chatin, B., Oudrhiri, N., Hauchekorne, M., Lambert, O., Vigneron, J.-P., Lehn, P., Pitard, B., Lehn, J.-M., Centre de recherche sur la Paléobiodiversité et les Paléoenvironnements (CR2P), Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Institut de Science et d'ingénierie supramoléculaires (ISIS), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

96. Royal Society of Chemistry Awards

Author

Stephan, D, Wright, D, Atwood, J, Cloke, F, Tsang, S, Lehn, J, Moody, C, O'Reilly, R, Taylor, R, Houk, K, and Colacot, T

Subjects
General Chemistry, Catalysis
Published
2012

97. Journées Systèmes Complexes Phyique Vers la Matière Complexe : Quelques Aspects d'une Chimie des Systèmes Complexes

Author

Lehn, J.-M., Bertrand, Annia, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Collège de France (CdF (institution)), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

98. 'Stabilized hemiacetal complexes as precursors for the controlled release of bioactive volatile alcohols', Chemistry & Biodiversity, 9, 689-701, 2012

Author

Buchs, B., Fieber, W., Drahonovsky, D., Lehn, J.-M., Herrmann, A., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Department of Experimental Medical Science, and AUTRES

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

99. 'Biodynamers: Self-organization-driven formatoin of doubly dynamic proteoids'

Author

Hirsch, A.K.H., Buhler, E., Lehn, J.-M., Matière et Systèmes Complexes (MSC (UMR_7057)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Science et d'ingénierie supramoléculaires (ISIS), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

100. Constitutional Dynamic Chemistry: Bridge from Supramolecular Chemistry to Adaptive Chemistry

Author

Lehn, J.-M., Bertrand, Annia, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and Collège de France (CdF (institution))

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

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