1,827 results on '"Legrand M"'
Search Results
52. Rigidité artérielle mesurée par pOpmètre® chez les patients à risque cardiovasculaire, lien aux plaques d’athérome carotidien
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Hallab, M., Collette, M., Terrier-Barbeau, C., Legrand, M., Ducluzeau, P.-H., Berrut, G., and Lefthériotis, G.
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- 2013
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53. L’embolie amniotique : mise au point
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Legrand, M., Rossignol, M., Muller, F., and Payen, D.
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- 2013
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54. Climate and atmospheric history of the past 420,000 years from the Vostok ice core, Antarctica
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Petit, J. R., Jouzel, J., Raynaud, D., Barkov, N. I., Barnola, J. M., Basile, I., Bender, M., Chappellaz, J., Davis, M., Delaygue, G., Delmotte, M., Kotlyakov, V. M., Legrand, M., Lipenkov, V. Y., Lorius, C., Pepin, L., Ritz, C., Saltzman, E., Stievenard, M., Petit, J. R., Jouzel, J., Raynaud, D., Barkov, N. I., Barnola, J. M., Basile, I., Bender, M., Chappellaz, J., Davis, M., Delaygue, G., Delmotte, M., Kotlyakov, V. M., Legrand, M., Lipenkov, V. Y., Lorius, C., Pepin, L., Ritz, C., Saltzman, E., and Stievenard, M.
- Abstract
The recent completion of drilling at Vostok station in East Antarctica has allowed the extension of the ice record of atmospheric composition and climate to the past four glacial-interglacial cycles. The succession of changes through each climate cycle and termination was similar, and atmospheric and climate properties oscillated between stable bounds. Interglacial periods differed in temporal evolution and duration. Atmospheric concentrations of carbon dioxide and methane correlate well with Antarctic air-temperature throughout the record. Present-day atmospheric burdens of these two important greenhouse gases seem to have been unprecedented during the past 420,000 years.
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- 2022
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55. Parcours de soins sur un an des patients survivant à la réanimation en France - Etude à partir des bases de données médico-administratives
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Martin, G., primary, Atramont, A., additional, Mazars, M., additional, Tajahmady, A., additional, Agamaliyev, E., additional, Leone, M., additional, and Legrand, M., additional
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- 2022
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56. Les fibrocytes circulants sont associés au pronostic dans la pneumopathie à SARS-CoV-2
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Ghanem, M., primary, Homps-Legrand, M., additional, Jaillet, M., additional, Mailleux, A., additional, Neukirch, C., additional, Borie, R., additional, Taillé, C., additional, and Crestani, B., additional
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- 2022
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57. Modulation of Atmospheric Dynamics and Dust Emissions in Southwest Asia by the Caspian Sea—Hindu Kush Index
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Kaskaoutis, D. G., primary, Houssos, E. E., additional, Rashki, A., additional, Bartzokas, A., additional, Legrand, M., additional, Francois, P., additional, and Kambezidis, H. D., additional
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- 2016
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58. How to assess beef and dairy products qualities according to farming systems: a review
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B. Martin, I. Legrand, M. Coppa and J.F. Hocquette
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- 2022
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59. Additional file 1 of Elevated plasma Galectin-3 is associated with major adverse kidney events and death after ICU admission
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Boutin, L., Legrand, M., Sadoune, M., Mebazaa, A., Gayat, E., Chadjichristos, C. E., and D��pret, F.
- Abstract
Additional file 1: Fig. S1���S13 and Table S1���S4. Elevated plasma Galectin-3 is associated with major adverse kidney events and death after ICU admission - Additional data.
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- 2022
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60. O-methyltransferase(s)-suppressed plants produce lower amounts of phenolic vir inducers and are less susceptible to Agrobacterium tumefaciens infection
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Maury, Stéphane, Delaunay, A., Mesnard, F., Crônier, D., Chabbert, B., Geoffroy, P., and Legrand, M.
- Published
- 2010
61. 1250 Years of Global Volcanism as Revealed by Central Greenland Ice Cores
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Clausen, H. B., Hammer, C. U., Christensen, J., Hvidberg, C. Schøtt, Dahl-Jensen, D., Legrand, M., Steffensen, J. P., and Delmas, Robert J., editor
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- 1995
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62. Impact of Galectin-3 tissue deletion in renal damage and type-3 cardio-renal syndrome
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Boutin, L., primary, Dépret, F., additional, Samuel, J., additional, Legrand, M., additional, Mebazaa, A., additional, and Gayat, E., additional
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- 2022
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63. Efficience d’un centre de référence de maladie rare : exemple de la dysplasie fibreuse des os
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Legrand, M., primary, Bagouet, F., additional, Merle, B., additional, Deborah, G., additional, and Chapurlat, R., additional
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- 2021
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64. Acute kidney injury in the critically ill: an updated review on pathophysiology and management
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Pickkers, P., Darmon, M., Hoste, E., Joannidis, M., Legrand, M., Ostermann, M., Prowle, J.R., Schneider, A., and Schetz, M.
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Acute Kidney Injury/diagnosis ,Acute Kidney Injury/etiology ,Acute Kidney Injury/therapy ,Biomarkers ,Critical Illness ,Humans ,Kidney ,Prognosis ,Acute kidney injury ,Blood pressure management ,Diagnosis ,Fluid therapy ,Heterogeneity ,Long-term consequences ,Machine learning ,Nephrotoxicity ,Organ cross-talk ,Pathophysiology ,Phenotypes ,Vasopressor - Abstract
Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only affects acute morbidity and mortality, but also a patient's long-term prognosis. In this narrative review, an update on various aspects of AKI in critically ill patients will be provided. Focus will be on prediction and early detection of AKI (e.g., the role of biomarkers to identify high-risk patients and the use of machine learning to predict AKI), aspects of pathophysiology and progress in the recognition of different phenotypes of AKI, as well as an update on nephrotoxicity and organ cross-talk. In addition, prevention of AKI (focusing on fluid management, kidney perfusion pressure, and the choice of vasopressor) and supportive treatment of AKI is discussed. Finally, post-AKI risk of long-term sequelae including incident or progression of chronic kidney disease, cardiovascular events and mortality, will be addressed.
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- 2021
65. Interest of Human Papillomavirus DNA quantification and genotyping in paired cervical and urine samples to detect cervical lesions
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Ducancelle, A., Legrand, M. C., Pivert, A., Veillon, P., Le Guillou-Guillemette, H., De Brux, M. A., Beby-Defaux, A., Agius, G., Hantz, S., Alain, S., Catala, L., Descamps, P., Postec, E., Caly, H., Charles-Pétillon, F., Labrousse, F., Lunel, F., and Payan, C.
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- 2014
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66. cDNA Cloning and Expression Studies of Tobacco Class III Chitinase-Lysozymes
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Stintzi, A., Geoffroy, P., Bersuder, D., Fritig, B., Legrand, M., Fritig, Bernard, editor, and Legrand, Michel, editor
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- 1993
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67. cDNA Cloning and Tissue-Specific Expression of the Lignification-Related O — Methyltransferase I in Healthy and TMV-Infected Tobacco
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Jaeck, E., Rohfritsch, O., Fritig, B., Legrand, M., Fritig, Bernard, editor, and Legrand, Michel, editor
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- 1993
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68. Molecular Cloning and Expression of an Inhibitor of Microbial Proteinases Induced During the Hypersensitive Reaction of Tobacco to TMV
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Heitz, T., Geoffroy, P., Fritig, B., Legrand, M., Fritig, Bernard, editor, and Legrand, Michel, editor
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- 1993
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69. Ice Core Analysis in Arctic and Antarctic Regions
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Legrand, M., Niki, H., editor, and Becker, K. H., editor
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- 1993
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70. On the recirculation of ammonia-lithium nitrate in adiabatic absorbers for chillers
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Ventas, R., Lecuona, A., Legrand, M., and Rodríguez-Hidalgo, M.C.
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- 2010
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71. Modeling of a rotor speed transient response with radial rubbing
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Roques, S., Legrand, M., Cartraud, P., Stoisser, C., and Pierre, C.
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- 2010
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72. Biological Activity of PR-Proteins from Tobacco; Characterization of a Proteinase Inhibitor
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Legrand, M., Stintzi, A., Heitz, T., Geoffroy, P., Kauffmann, S., Fritig, B., Bliss, F. A., editor, Hennecke, Hauke, editor, and Verma, Desh Pal S., editor
- Published
- 1991
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73. PC.62 - Apport des soins pharmaceutiques pour améliorer la prise en charge médicamenteuse des patients atteints de rhumatisme inflammatoire chronique
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Bonnet, M., Estublier, C., Laloi, L., Vignot, E., Confavreux, C., Fontana, A., Benhamou, J., Gensburger, D., Fontanges, E., Beaumel, A., Massy, E., Legrand, M., Raby, A.L., Bienvenu, F.H., Grapinet, J., Jaulent, P., Debastiani, C., Chapurlat, R., Pivot, C., and Janoly-Dumenil, A.
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- 2016
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74. Defence Proteins, Glycanhydrolases and Oligosaccharide Signals in Plant-Virus Interactions
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Fritig, B., Kauffmann, S., Rouster, J., Dumas, B., Geoffroy, P., Kopp, M., Legrand, M., and Fraser, Ron S. S., editor
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- 1990
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75. Séparation à la source et valorisation des excrétas humains du Grand Paris : des filières émergentes
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LEGRAND, M., primary, JOVENIAUX, A., additional, ARBAROTTI, A., additional, DE GOUVELLO, B., additional, ESCULIER, F., additional, and TABUCHI, J.-P., additional
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- 2021
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76. Impact of Galectin-3 tissue deletion in renal damage and type-3 cardio-renal syndrome
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Boutin, L., primary, Dépret, F., additional, Samuel, J.L., additional, Legrand, M., additional, Mebazaa, A., additional, Gayat, E., additional, and Chadjichristos, C., additional
- Published
- 2021
- Full Text
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77. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016
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Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., Artigas, A., Martin-Loeches, I., Hoogendijk, A., van der Poll, T., Horn, J., Juffermans, N., Schultz, M., de Prost, N., Pham, T., Carteaux, G., Dessap, A. Mekontso, Brun-Buisson, C., Fan, E., Bellani, G., Laffey, J., Mercat, A., Brochard, L., Maitre, B., Howells, P. A., Thickett, D. R., Knox, C., Park, D. P., Gao, F., Tucker, O., Whitehouse, T., McAuley, D. F., Perkins, G. D., Pham, T., Laffey, J., Bellani, G., Fan, E., Pisani, L., Roozeman, J. P., Simonis, F. D., Giangregorio, A., Schouten, L. R., Van der Hoeven, S. M., Horn, J., Neto, A. Serpa, Festic, E., Dondorp, A. M., Grasso, S., Bos, L. D., Schultz, M. J., Koster-Brouwer, M., Verboom, D., Scicluna, B., van de Groep, K., Frencken, J., Schultz, M., van der Poll, T., Bonten, M., Cremer, O., Ko, J. I., Kim, K. S., Suh, G. J., Kwon, W. Y., Kim, K., Shin, J. H., Ranzani, O. T., Prina, E., Menendez, R., Ceccato, A., Mendez, R., Cilloniz, C., Gabarrus, A., Ferrer, M., Torres, A., Urbano, A., Zhang, L. A., Swigon, D., Pike, F., Parker, R. S., Clermont, G., Scheer, C., Kuhn, S. O., Modler, A., Vollmer, M., Fuchs, C., Hahnenkamp, K., Rehberg, S., Gründling, M., Taggu, A., Darang, N., Öveges, N., László, I., Tánczos, K., Németh, M., Lebák, G., Tudor, B., Érces, D., Kaszaki, J., Huber, W., Trásy, D., Molnár, Z., Ferrara, G., Edul, V. S. Kanoore, Canales, H. S., Martins, E., Canullán, C., Murias, G., Pozo, M. O., Eguillor, J. F. Caminos, Buscetti, M. G., Ince, C., Dubin, A., Aya, H. D., Rhodes, A., Fletcher, N., Grounds, R. M., Cecconi, M., Jacquet-Lagrèze, M., Riche, M., Schweizer, R., Portran, P., Fornier, W., Lilot, M., Neidecker, J., Fellahi, J. L., Escoresca-Ortega, A., Gutiérrez-Pizarraya, A., Charris-Castro, L., Corcia-Palomo, Y., Fernandez-Delgado, E., Garnacho-Montero, J., Roger, C., Muller, L., Elotmani, L., Lipman, J., Lefrant, J. Y., Roberts, J. A., Muñoz-Bermúdez, R., Samper, M., Climent, C., Vasco, F., Sara, V., Luque, S., Campillo, N., Cerrato, S. Grau, Masclans, J. R., Alvarez-Lerma, F., Brugger, S. Carvalho, Jimenez, G. Jimenez, Torner, M. Miralbés, Cabello, J. Trujillano, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Vidal, M. Vallverdú, Martínez, M. Palomar, Gusarov, V., Shilkin, D., Dementienko, M., Nesterova, E., Lashenkova, N., Kuzovlev, A., Zamyatin, M., Demoule, A., Carreira, S., Lavault, S., Palancca, O., Morawiec, E., Mayaux, J., Arnulf, I., Similowski, T., Rasmussen, B. S., Maltesen, R. G., Hanifa, M., Pedersen, S., Kristensen, S. R., Wimmer, R., Panigada, M., Bassi, G. Li, Ranzani, O. T., Kolobow, T., Zanella, A., Cressoni, M., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Andreotti, A., Tagliaferri, F., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Consonni, D., Pesenti, A., Gattinoni, L., Torres, A., Mansouri, P., Zand, F., Zahed, L., Dehghanrad, F., Bahrani, M., Ghorbani, M., Cambiaghi, B., Moerer, O., Mauri, T., Kunze-Szikszay, N., Ritter, C., Pesenti, A., Quintel, M., Vilander, L. M., Kaunisto, M. A., Vaara, S. T., Pettilä, V., Mulier, J. L. G. Haitsma, Rozemeijer, S., Spoelstra-de Man, A. M. E., Elbers, P. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Koh, I. H. J., Martínez, M. Galindo, Sánchez, R. Jiménez, Gascón, L. Martínez, Mulero, M. D. Rodríguez, Freire, A. Ortín, Muñoz, A. Ojados, Acebes, S. Rebollo, Martínez, Á. Fernández, Aliaga, S. Moreno, Para, L. Herrera, Payá, J. Murcia, Mulero, F. Rodríguez, Guerci, P., Ince, Y., Heeman, P., Ergin, B., Ince, C., Uz, Z., Massey, M., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Toraman, F., Ince, C., Longbottom, E. R., Torrance, H. D., Owen, H. C., Hinds, C. J., Pearse, R. M., O’Dywer, M. J., Trogrlic, Z., van der Jagt, M., Lingsma, H., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., van Achterberg, T., Bakker, J., Gommers, D. A. M. P. J., Ista, E., Krajčová, A., Waldauf, P., Duška, F., Shah, A., Roy, N., McKechnie, S., Doree, C., Fisher, S., Stanworth, S. J., Jensen, J. F., Overgaard, D., Bestle, M. H., Christensen, D. F., Egerod, I., Pivkina, A., Gusarov, V., Zhivotneva, I., Pasko, N., Zamyatin, M., Jensen, J. F., Egerod, I., Bestle, M. H., Christensen, D. F., Alklit, A., Hansen, R. L., Knudsen, H., Grode, L. B., Overgaard, D., Hravnak, M., Chen, L., Dubrawski, A., Clermont, G., Pinsky, M. R., Parry, S. M., Knight, L. D., Connolly, B. C., Baldwin, C. E., Puthucheary, Z. A., Denehy, L., Hart, N., Morris, P. E., Mortimore, J., Granger, C. L., Jensen, H. I., Piers, R., Van den Bulcke, B., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Van den Bulcke, B., Piers, R., Jensen, H. I., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Ryan, C., Dawson, D., Ball, J., Noone, K., Aisling, B., Prudden, S., Ntantana, A., Matamis, D., Savvidou, S., Giannakou, M., Gouva, M., Nakos, G., Koulouras, V., Aron, J., Lumley, G., Milliken, D., Dhadwal, K., McGrath, B. A., Lynch, S. J., Bovento, B., Sharpe, G., Grainger, E., Pieri-Davies, S., Wallace, S., McGrath, B., Lynch, S. J., Bovento, B., Grainger, E., Pieri-Davies, S., Sharpe, G., Wallace, S., Jung, M., Cho, J., Park, H., Suh, G., Kousha, O., Paddle, J., Gripenberg, L. Gamrin, Rehal, M. Sundström, Wernerman, J., Rooyackers, O., de Grooth, H. J., Choo, W. P., Spoelstra-de Man, A. M., Swart, E. L., Oudemans-van Straaten, H. M., Talan, L., Güven, G., Altıntas, N. D., Padar, M., Uusvel, G., Starkopf, L., Starkopf, J., Blaser, A. Reintam, Kalaiselvan, M. S., Arunkumar, A. S., Renuka, M. K., Shivkumar, R. L., Volbeda, M., ten Kate, D., Hoekstra, M., van der Maaten, J. M., Nijsten, M. W., Komaromi, A., Rooyackers, O., Wernerman, J., Norberg, Å., Smedberg, M., Mori, M., Pettersson, L., Norberg, Å., Rooyackers, O., Wernerman, J., Theodorakopoulou, M., Christodoulopoulou, T., Diamantakis, A., Frantzeskaki, F., Kontogiorgi, M., Chrysanthopoulou, E., Lygnos, M., Diakaki, C., Armaganidis, A., Gundogan, K., Dogan, E., Coskun, R., Muhtaroglu, S., Sungur, M., Ziegler, T., Guven, M., Kleyman, A., Khaliq, W., Andreas, D., Singer, M., Meierhans, R., Schuepbach, R., De Brito-Ashurst, I., Zand, F., Sabetian, G., Nikandish, R., Hagar, F., Masjedi, M., Maghsudi, B., Vazin, A., Ghorbani, M., Asadpour, E., Kao, K. C., Chiu, L. C., Hung, C. Y., Chang, C. H., Li, S. H., Hu, H. C., El Maraghi, S., Ali, M., Rageb, D., Helmy, M., Marin-Corral, J., Vilà, C., Masclans, J. R., Vàzquez, A., Martín-Loeches, I., Díaz, E., Yébenes, J. C., Rodriguez, A., Álvarez-Lerma, F., Varga, N., Cortina-Gutiérrez, A., Dono, L., Martínez-Martínez, M., Maldonado, C., Papiol, E., Pérez-Carrasco, M., Ferrer, R., Nweze, K., Morton, B., Welters, I., Houard, M., Voisin, B., Ledoux, G., Six, S., Jaillette, E., Nseir, S., Romdhani, S., Bouneb, R., Loghmari, D., Aicha, N. Ben, Ayachi, J., Meddeb, K., Chouchène, I., Khedher, A., Boussarsar, M., Chan, K. S., Yu, W. L., Marin-Corral, J., Vilà, C., Masclans, J. R., Nolla, J., Vidaur, L., Bonastre, J., Suberbiola, B., Guerrero, J. E., Rodriguez, A., Coll, N. Ramon, Jiménez, G. Jiménez, Brugger, S. Carvalho, Calero, J. Codina, Garrido, B. Balsera, García, M., Martínez, M. Palomar, Vidal, M. Vallverdú, de la Torre, M. C., Vendrell, E., Palomera, E., Güell, E., Yébenes, J. C., Serra-Prat, M., Bermejo-Martín, J. F., Almirall, J., Tomas, E., Escoval, A., Froe, F., Pereira, M. H. Vitoria, Velez, N., Viegas, E., Filipe, E., Groves, C., Reay, M., Chiu, L. C., Hu, H. C., Hung, C. Y., Chang, C. H., Li, S. H., Kao, K. C., Ballin, A., Facchin, F., Sartori, G., Zarantonello, F., Campello, E., Radu, C. M., Rossi, S., Ori, C., Simioni, P., Umei, N., Shingo, I., Santos, A. C., Candeias, C., Moniz, I., Marçal, R., e Silva, Z. Costa, Ribeiro, J. M., Georger, J. F., Ponthus, J. P., Tchir, M., Amilien, V., Ayoub, M., Barsam, E., Martucci, G., Panarello, G., Tuzzolino, F., Capitanio, G., Ferrazza, V., Carollo, T., Giovanni, L., Arcadipane, A., Sánchez, M. López, González-Gay, M. A., Díaz, F. J. Llorca, López, M. I. Rubio, Zogheib, E., Villeret, L., Nader, J., Bernasinski, M., Besserve, P., Caus, T., Dupont, H., Morimont, P., Habran, S., Hubert, R., Desaive, T., Blaffart, F., Janssen, N., Guiot, J., Pironet, A., Dauby, P., Lambermont, B., Zarantonello, F., Ballin, A., Facchin, F., Sartori, G., Campello, E., Pettenuzzo, T., Citton, G., Rossi, S., Simioni, P., Ori, C., Kirakli, C., Ediboglu, O., Ataman, S., Yarici, M., Tuksavul, F., Keating, S., Gibson, A., Gilles, M., Dunn, M., Price, G., Young, N., Remeta, P., Bishop, P., Zamora, M. D. Fernández, Muñoz-Bono, J., Curiel-Balsera, E., Aguilar-Alonso, E., Hinojosa, R., Gordillo-Brenes, A., Arboleda-Sánchez, J. A., Skorniakov, I., Vikulova, D., Whiteley, C., Shaikh, O., Jones, A., Ostermann, M., Forni, L., Scott, M., Sahatjian, J., Linde-Zwirble, W., Hansell, D., Laoveeravat, P., Srisawat, N., Kongwibulwut, M., Peerapornrattana, S., Suwachittanont, N., Wirotwan, T. O., Chatkaew, P., Saeyub, P., Latthaprecha, K., Tiranathanagul, K., Eiam-ong, S., Kellum, J. A., Berthelsen, R. E., Perner, A., Jensen, A. E. K., Jensen, J. U., Bestle, M. H., Gebhard, D. J., Price, J., Kennedy, C. E., Akcan-Arikan, A., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Kang, Y. R., Nakamae, M. N., Koh, I. H. J., Hamed, K., Khaled, M. M., Soliman, R. Aly, Mokhtar, M. Sherif, Seller-Pérez, G., Arias-Verdú, D., Llopar-Valdor, E., De-Diós-Chacón, I., Quesada-García, G., Herrera-Gutierrez, M. E., Hafes, R., Carroll, G., Doherty, P., Wright, C., Vera, I. G. Guerra, Ralston, M., Gemmell, M. L., MacKay, A., Black, E., Wright, C., Docking, R. I., Appleton, R., Ralston, M. R., Gemmell, L., Appleton, R., Wright, C., Docking, R. I., Black, E., Mackay, A., Rozemeijer, S., Mulier, J. L. G. Haitsma, Röttgering, J. G., Elbers, P. W. G., Spoelstra-de Man, A. M. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. 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C., Tang, Z., Qiu, C., Tong, L., Cai, C., Theodorakopoulou, M., Diamantakis, A., Kontogiorgi, M., Chrysanthopoulou, E., Christodoulopoulou, T., Frantzeskaki, F., Lygnos, M., Apostolopoulou, O., Armaganidis, A., Moon, J. Y., Park, M. R., Kwon, I. S., Chon, G. R., Ahn, J. Y., Kwon, S. J., Chang, Y. J., Lee, J. Y., Yoon, S. Y., Lee, J. W., Kostalas, M., Mckinlay, J., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Altintas, N. D., Izdes, S., Keremoglu, O., Alkan, A., Neselioglu, S., Erel, O., Tardif, N., Gustafsson, T., Rooyackers, O., MacEachern, K. N., Traille, M., Bromberg, I., Lapinsky, S. E., Moore, M. J., Tang, Z., Cai, C., Tong, L., García-Garmendia, J. L., Villarrasa-Clemente, F., Maroto-Monserrat, F., Rufo-Tejeiro, O., Jorge-Amigo, V., Sánchez-Santamaría, M., Colón-Pallarés, C., Barrero-Almodóvar, A., Gallego-Lara, S., Anthon, C. T., Müller, R. B., Haase, N., Møller, K., Hjortrup, P. B., Wetterslev, J., Perner, A., Nakanishi, M., Kuriyama, A., Fukuoka, T., Abd el Halim, M. A., Elsaid hafez, M. H., Moktar, A. M., Eladawy, A., Elazizy, H. M., Hakim, K. Abdel, Chaari, A., Elbahr, M., Ismail, M., Mahmoud, T., Kauts, V., Bousselmi, K., Khalil, E., Casey, W., Zaky, S. H., Rizk, A., Elghonemi, M. O., Ahmed, R., Vieira, J. C. F., Souza, R. B., Liberatore, A. M. A., Koh, I. H. J., Ospina-Tascón, G. A., Marin, A. F. Garcia, Echeverry, G. J., Bermudez, W. F., Madriñan-Navia, H. J., Valencia, J. D., Quiñonez, E., Marulanda, A., Arango-Dávila, C. A., Bruhn, A., Hernandez, G., De Backer, D., Cortes, D. Orbegozo, Su, F., Vincent, J. L., Creteur, J., Tullo, L., Mirabella, L., Di Molfetta, P., Cinnella, G., Dambrosio, M., Lujan, C. Villavicencio, irigoyen, J. Leache, Cartanya ferré, M., García, R. Carbonell, Mukhtar, A., Ahmed, M., El Ayashi, M., Hasanin, A., Ayman, E., Salem, M., Eladawy, A., Fathy, S., Nassar, H., Zaghlol, A., Arzapalo, M. F. Aguilar, Valsø, Å., Sunde, K., Rustøen, T., Schou-Bredal, I., Skogstad, L., Tøien, K., Padilla, C., Palmeiro, Y., Egbaria, W., Kigli, R., Maertens, B., Blot, K., Blot, S., Santana-Santos, E., dos Santos, E. R., Ferretti-Rebustini, R. E. D. L., dos Santos, R. D. C. C. D. O., Verardino, R. G. S., Bortolotto, L. A., Doyle, A. M., Naldrett, I., Tillman, J., Price, S., Shrestha, S., Pearson, P., Greaves, J., Goodall, D., Berry, A., Richardson, A., Odundo, G. O., Omengo, P., Obonyo, P., Chanzu, N. M., Kleinpell, R., Sarris, S. J., Nedved, P., Heitschmidt, M., Ben-Ghezala, H., Snouda, S., Djobbi, S., Ben-Ghezala, H., Snouda, S., Rose, L., Adhikari, N. K. J., Leasa, D., Fergusson, D., Mckim, D. A., Weblin, J., Tucker, O., McWilliams, D., Doesburg, F., Cnossen, F., Dieperink, W., Bult, W., Nijsten, M. W. N., Galvez-Blanco, G. A., Zepeda, E. Monares, Guzman, C. I. Olvera, Sánchez, J. S. Aguirre, Granillo, J. Franco, Stroud, J. Santos, Thomson, R., Llaurado-Serra, M., Lobo-Civico, A., Pi-Guerrero, M., Blanco-Sanchez, I., Piñol-Tena, A., Paños-Espinosa, C., Alabart-Segura, Y., Coloma-Gomez, B., Fernandez-Blanco, A., Braga-Dias, F., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Prada, R., Juárez, P., Argandoña, R., Díaz, J. J., Ramirez, C. Sánchez, Saavedra, P., Santana, S. Ruiz, Obukhova, O., Kashiya, S., Kurmukov, I. A., Pronina, A. M., Simeone, P., Puybasset, L., Auzias, G., Coulon, O., Lesimple, B., Torkomian, G., Velly, L., Bienert, A., Bartkowska-Sniatkowska, A., Wiczling, P., Szerkus, O., Siluk, D., Bartkowiak-Wieczorek, J., Rosada-Kurasinska, J., Warzybok, J., Borsuk, A., Kaliszan, R., Grzeskowiak, E., Caballero, C. Hernandez, Roberts, S., Isgro, G., Hall, D., Guillaume, G., Passouant, O., Dumas, F., Bougouin, W., Champigneulle, B., Arnaout, M., Chelly, J., Chiche, J. D., Varenne, O., Mira, J. P., Marijon, E., Cariou, A., Beerepoot, M., Touw, H. R., Parlevliet, K., Boer, C., Elbers, P. W., Tuinman, P. R., Reina, Á. J. Roldán, Palomo, Y. Corcia, Bermúdez, R. Martín, Villén, L. Martín, García, I. Palacios, Izurieta, J. R. Naranjo, Bernal, J. B. Pérez, Jiménez, F. J. Jiménez, Cota-Delgado, F., de la Torre-Prados, M. V., Fernández-Porcel, A., Nuevo-Ortega, P., Cámara-Sola, E., Tsvetanova-Spasova, T., Rueda-Molina, C., Salido-Díaz, L., García-Alcántara, A., Kaneko, T., Tanaka, H., Kamikawa, M., Karashima, R., Iwashita, S., Irie, H., Kasaoka, S., Arola, O., Laitio, R., Saraste, A., Airaksinen, J., Pietilä, M., Hynninen, M., Wennervirta, J., Bäcklund, M., Ylikoski, E., Silvasti, P., Nukarinen, E., Grönlund, J., Harjola, V. P., Niiranen, J., Korpi, K., Varpula, M., Roine, R. O., Laitio, T., Salah, S., Hassen, B. G., Fehmi, A. Mohamed, Kim, S., Hsu, Y. C., Barea-Mendoza, J., García-Fuentes, C., Castillo-Jaramillo, M., Dominguez-Aguado, H., Viejo-Moreno, R., Terceros-Almanza, L., Aznárez, S. Bermejo, Mudarra-Reche, C., Xu, W., Chico-Fernández, M., Montejo-González, J. C., Crewdson, K., Thomas, M., Merghani, M., Fenner, L., Morgan, P., Lockey, D., van Lieshout, E. J., Oomen, B., Binnekade, J. M., Dongelmans, D. A., de Haan, R. J., Juffermans, N. P., Vroom, M. B., Algarte, R., Martínez, L., Sánchez, B., Romero, I., Martínez, F., Quintana, S., Trenado, J., Sheikh, O., Pogson, D., Clinton, R., Riccio, F., Gemmell, L., MacKay, A., Arthur, A., Young, L., Sinclair, A., Markopoulou, D., Venetsanou, K., Filippou, L., Salla, E., Stratouli, S., Alamanos, I., Guirgis, A. H., Rodriguez, R. Gutiérrez, Lorente, M. J. Furones, Guarasa, I. Macias, Ukere, A., Meisner, S., Greiwe, G., Opitz, B., Benten, D., Nashan, B., Fischer, L., Trepte, C. J. C., Reuter, D. A., Haas, S. A., Behem, C. R., Tavazzi, G., Ana, B., Vazir, A., Gibson, D., Price, S., Masjedi, M., Hadavi, M. R., alam, M. Riahi, Sasani, M. R., Parenti, N., Agrusta, F., Palazzi, C., Pifferi, B., Sganzerla, R., Tagliazucchi, F., Luciani, A., Möller, M., Müller-Engelmann, J., Montag, G., Adams, P., Lange, C., Neuzner, J., Gradaus, R., Wodack, K. H., Thürk, F., Waldmann, A. D., Grässler, M. F., Nishimoto, S., Böhm, S. H., Kaniusas, E., Reuter, D. A., Trepte, C. J., Sigmundsson, T., Öhman, T., Redondo, E., Hallbäck, M., Wallin, M., Sipman, F. Suarez, Oldner, A., Sander, C. Hällsjö, Björne, H., Colinas, L., Hernandez, G., Vicho, R., Serna, M., Cuena, R., Canabal, A., Chaari, A., Hakim, K. Abdel, Etman, M., El Bahr, M., El Sakka, A., Bousselmi, K., Arali, A., Kauts, V., Casey, W. F., Bond, O., De Santis, P., Iesu, E., Franchi, F., Vincent, J. L., Creteur, J., Scolletta, S., Taccone, F. S., Marutyan, Z., Hamidova, L., Shakotko, A., Movsisyan, V., Uysupova, I., Evdokimov, A., Petrikov, S., Gonen, C., Haftacı, E., Balci, C., Calvo, F. J. Redondo, Bejarano, N., Baladron, V., Villazala, R., Redondo, J., Padilla, D., Villarejo, P., Akcan-Arikan, A., Kennedy, C. E., Arzapalo, M. F. Aguilar, Gomez-Gonzalez, C., Mas-Font, S., Puppo-Moreno, A., Herrera-Gutierrez, M., Garcia-Garcia, M., Aldunate-Calvo, S., Plata-Menchaca, E. P., Pérez-Fernández, X. L., Estruch, M., Betbese-Roig, A., Campos, P. Cárdenas, Lora, M. Rojas, Gaibor, N. D. Toapanta, Medina, R. S. Contreras, Sanguino, V. D. Gumucio, Casanova, E. J., Riera, J. Sabater, Kritmetapak, K., Peerapornratana, S., Kittiskulnam, P., Dissayabutra, T., Tiranathanagul, K., Susantithapong, P., Praditpornsilpa, K., Tungsanga, K., Eiam-Ong, S., Srisawat, N., Winkelmann, T., Busch, T., Meixensberger, J., Bercker, S., Cabeza, E. M. Flores, Sánchez, M. Sánchez, Giménez, N. Cáceres, Melón, C. Gutierrez, de Lucas, E. Herrero, Estañ, P. Millán, Bernal, M. Hernández, de Lorenzo y Mateos, A. Garcia, Ergin, B., Guerci, P., Specht, P. A. C., Ince, Y., Ince, C., Balik, M., Zakharchenko, M., Los, F., Brodska, H., de Tymowski, C., Augustin, P., Desmard, M., Montravers, P., Stapel, S. N., de Boer, R., Oudemans, H. M., Hollinger, A., Schweingruber, T., Jockers, F., Dickenmann, M., Siegemund, M., Runciman, N., Ralston, M., Appleton, R., Mauri, T., Alban, L., Turrini, C., Sasso, T., Langer, T., Panigada, M., Taccone, P., Carlesso, E., Marenghi, C., Grasselli, G., Pesenti, A., Wibart, P., Reginault, T., Garcia, M., Barbrel, B., Benard, A., Bader, C., Vargas, F., Bui, H. N., Hilbert, G., Simón, J. M. Serrano, Sánchez, P. Carmona, Ferrón, F. Ruiz, de Acilu, M. García, Marin, J., Antonia, V., Ruano, L., Monica, M., Ferrer, R., Masclans, J. R., Roca, O., Hong, G., Kim, D. H., Kim, Y. S., Park, J. S., Jee, Y. K., xiang, Z. Yu, Jia-xing, W., dan, W. Xiao, long, N. Wen, Yu, W., Yan, Z., Cheng, X., Kobayashi, T., Onodera, Y., Akimoto, R., Sugiura, A., Suzuki, H., Iwabuchi, M., Nakane, M., Kawamae, K., Sanchez, P. Carmona, Rodriguez, M. D. Bautista, Delgado, M. Rodriguez, Sánchez, V. Martínez de Pinillos, Gómez, A. Mula, Simón, J. M. Serrano, Beuret, P., Fortes, C., Lauer, M., Reboul, M., Chakarian, J. C., Fabre, X., Philippon-Jouve, B., Devillez, S., Clerc, M., Rittayamai, N., Sklar, M., Dres, M., Rauseo, M., Campbell, C., West, B., Tullis, D. E., Brochard, L., Onodera, Y., Akimoto, R., Suzuki, H., Okada, M., Nakane, M., Kawamae, K., Ahmad, N., Wood, M., Glossop, A., Lucas, J. Higuera, Ortiz, A. Blandino, Alonso, D. Cabestrero, De Pablo Sánchez, R., González, L. Rey, Costa, R., Spinazzola, G., Pizza, A., Ferrone, G., Rossi, M., Antonelli, M., Conti, G., Ribeiro, H., Alves, J., Sousa, M., Reis, P., Socolovsky, C. S., Cauley, R. P., Frankel, J. E., Beam, A. L., Olaniran, K. O., Gibbons, F. K., Christopher, K. B., Pennington, J., Zolfaghari, P., King, H. S., Kong, H. H. Y., Shum, H. P., Yan, W. W., Kaymak, C., Okumus, N., Sari, A., Erdogdu, B., Aksun, S., Basar, H., Ozcan, A., Ozcan, N., Oztuna, D., Malmgren, J. A., Lundin, S., Torén, K., Eckerström, M., Wallin, A., Waldenström, A. C., Riccio, F. C., Pogson, D., Antonio, A. C. P., Leivas, A. F., Kenji, F., James, E., Morgan, P., Carroll, G., Gemmell, L., MacKay, A., Wright, C., Ballantyne, J., Jonnada, S., Gerrard, C. S., Jones, N., Salciccioli, J. D., Marshall, D. C., Komorowski, M., Hartley, A., Sykes, M. C., Goodson, R., Shalhoub, J., Villanueva, J. R. Fernández, Garda, R. Fernández, Lago, A. M. López, Ruiz, E. Rodríguez, Vaquero, R. Hernández, Rodríguez, C. Galbán, Pérez, E. Varo, Hilasque, C., Oliva, I., Sirgo, G., Martin, M. C., Olona, M., Gilavert, M. C., Bodí, M., Ebm, C., Aggarwal, G., Huddart, S., Quiney, N., Cecconi, M., Fernandes, S. M., Silva, J. Santos, Gouveia, J., Silva, D., Marques, R., Bento, H., Alvarez, A., Silva, Z. Costa, Diaz, D. Díaz, Martínez, M. Villanova, Herrejon, E. Palencia, de la Gandara, A. Martinez, Gonzalo, G., Lopez, M. A., de Gopegui Miguelena, P. Ruíz, Matilla, C. I. Bernal, Chueca, P. Sánchez, Longares, M. D. C. Rodríguez, Abril, R. Ramos, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Fernández, R. Fernández, Laborías, P. Morales, Castellanos, M. A. Díaz, Laborías, M. E. Morales, Cho, J., Kim, J., Park, J., Woo, S., West, T., Powell, E., Rimmer, A., Orford, C., Jones, N., Williams, J., Matilla, C. I. Bernal, de Gopegui Miguelena, P. Ruiz, Chueca, P. Sánchez, Abril, R. Ramos, Longares, M. D. C. Rodríguez, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Bourne, R. S., Shulman, R., Tomlin, M., Mills, G. H., Borthwick, M., Berry, W., Huertas, D. García, Manzano, F., Villagrán-Ramírez, F., Ruiz-Perea, A., Rodríguez-Mejías, C., Santiago-Ruiz, F., Colmenero-Ruiz, M., König, C., Matt, B., Kortgen, A., Hartog, C. S., Wong, A., Balan, C., Barker, G., Srisawat, N., Peerapornratana, S., Laoveeravat, P., Tachaboon, S., Eiam-ong, S., Paratz, J., Kayambu, G., Boots, R., Arzapalo, M. F. Aguilar, Vlasenko, R., Gromova, E., Loginov, S., Kiselevskiy, M., Dolgikova, Y., Tang, K. B., Chau, C. M., Lam, K. N., Gil, E., Suh, G. Y., Park, C. M., Park, J., Chung, C. R., Lee, C. T., Chao, A., Shih, P. Y., Chang, Y. F., Lai, C. H., Hsu, Y. C., Yeh, Y. C., Cheng, Y. J., Colella, V., Zarrillo, N., D’Amico, M., Forfori, F., Pezza, B., Laddomada, T., Beltramelli, V., Pizzaballa, M. L., Doronzio, A., Balicco, B., Kiers, D., van der Heijden, W., Gerretsen, J., de Mast, Q., el Messaoudi, S., Rongen, G., Gomes, M., Kox, M., Pickkers, P., Riksen, N. P., Kashiwagi, Y., Okada, M., Hayashi, K., Inagaki, Y., Fujita, S., Nakamae, M. N., Kang, Y. R., Souza, R. B., Liberatore, A. M. A., Koh, I. H. J., Blet, A., Sadoune, M., Lemarié, J., Bihry, N., Bern, R., Polidano, E., Merval, R., Launay, J. M., Lévy, B., Samuel, J. L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.
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- 2016
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78. Conséquences de l’hypoxémie aiguë sur la fonction rénale
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Darmon, M., Legrand, M., Coudrot, M., and Zeni, F.
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- 2009
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79. Inhibiting FAK–Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells
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Mousson A, Legrand M, Steffan T, Vauchelles R, Carl P, Gies J, Lehmann M, Guy Zuber, De Mey J, Dujardin D, Sick E, Rondé P, Biophotonique et Pharmacologie (CNRS UMR 7213), Centre National de la Recherche Scientifique (CNRS), Laboratoire de Bioimagerie et Pathologies (LBP), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Biotechnologie et signalisation cellulaire (BSC), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS)
- Subjects
paxillin ,tyrosine kinase inhibitor ,FAK ,[SDV]Life Sciences [q-bio] ,melanoma ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,biological phenomena, cell phenomena, and immunity ,migration ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Sciences du Vivant [q-bio]/Cancer ,lcsh:RC254-282 ,Article ,invadopodia - Abstract
Simple Summary The focal adhesion kinase (FAK) is over-expressed in a variety of human tumors and is involved in many aspects of the metastatic process. This has led to the development of small inhibitors of FAK kinase function which are currently evaluated in clinical trials. We demonstrate here that this class of inhibitors, while decreasing melanoma cell migration, increases invadopodia activity in metastatic melanoma cells. Searching for an alternative strategy to inhibit the oncogenic activity of FAK, we show that inhibiting FAK scaffolding function using a small peptide altering FAK–paxillin interactions reduces both migration and invadopodia-mediated matrix degradation in metastatic melanoma cells. Abstract The nonreceptor tyrosine kinase FAK is a promising target for solid tumor treatment because it promotes invasion, tumor progression, and drug resistance when overexpressed. Investigating the role of FAK in human melanoma cells, we found that both in situ and metastatic melanoma cells strongly express FAK, where it controls tumor cells’ invasiveness by regulating focal adhesion-mediated cell motility. Inhibiting FAK in human metastatic melanoma cells with either siRNA or a small inhibitor targeting the kinase domain impaired migration but led to increased invadopodia formation and extracellular matrix degradation. Using FAK mutated at Y397, we found that this unexpected increase in invadopodia activity is due to the lack of phosphorylation at this residue. To preserve FAK–Src interaction while inhibiting pro-migratory functions of FAK, we found that altering FAK–paxillin interaction, with either FAK mutation in the focal adhesion targeting (FAT) domain or a competitive inhibitor peptide mimicking paxillin LD domains drastically reduces cell migration and matrix degradation by preserving FAK activity in the cytoplasm. In conclusion, our data show that targeting FAK–paxillin interactions could be a potential therapeutic strategy to prevent metastasis formation, and molecules targeting this interface could be alternative to inhibitors of FAK kinase activity which display unexpected effects.
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- 2021
80. Early diagnosis and monitoring of mucormycosis by detection of circulating DNA in serum: retrospective analysis of 44 cases collected through the French Surveillance Network of Invasive Fungal Infections (RESSIF)
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Dupont, H., Marolleau, J.P., Totet, A., Damiani, C., Berceanu, A., Larosa, F., Bonhomme, J., Chabrot, C., Bouteille, B., Boutoille, D., Gastinne, T., Peterlin, P., Gari Toussaint, M., Poisson, D., Briet, D., Buret, J., Legrand, M., Denis, B., Raffoux, E., Bergeron, A., Veinstein, A., Godet, C., N'guyen, Y., Diallo, S., Sabou, M., Denis, J., Ledoux, M.P., Recher, C., Ruiz, J., Desoubeaux, G., Bailly, E., Chachaty, E., Dromer, F., Lortholary, O., Sitbon, K., Hoinard, D., Millon, L., Herbrecht, R., Grenouillet, F., Morio, F., Alanio, A., Letscher-Bru, V., Cassaing, S., Chouaki, T., Kauffmann-Lacroix, C., Poirier, P., Toubas, D., Augereau, O., Rocchi, S., Garcia-Hermoso, D., and Bretagne, S.
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- 2016
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81. Atmospheric Composition and Biogeochemical Cycles over the Last Million Years
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Chappellaz, J., primary, Legrand, M., additional, Delmas, R., additional, Bopp, L., additional, and Friedlingstein, P., additional
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- 2014
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82. Ammonium in Antarctic Aerosol: Marine Biological Activity Versus Long‐Range Transport of Biomass Burning
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Legrand, M., primary, Weller, R., additional, Preunkert, S., additional, and Jourdain, B., additional
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- 2021
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83. Étude du lignage des cellules exprimant le facteur de transcription mésenchymateux profibrosant Prrx1 (Paired Related Homeobox protein 1) dans le poumon normal et de fibrose chez la souris
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Homps-Legrand, M., primary, Jaillet, M., additional, Deneuville, L., additional, Gautier, G., additional, Crestani, B., additional, and Mailleux, A., additional
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- 2021
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84. Involvement of Circulating Fibrocytes in Pathophysiology and Prognosis of COVID-19 Pneumonia
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Ghanem, M., primary, Homps-Legrand, M., additional, Morer, L., additional, Goletto, T., additional, Frija, J., additional, Bancal, C., additional, Hurtado-Nedelec, M., additional, Jaillet, M., additional, Mailleux, A., additional, Neukirch, C., additional, Borie, R., additional, Taille, C., additional, and Crestani, B., additional
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- 2021
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85. The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives
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D'Enfert, C., Kaune, A.K., Alaban, L.R., Chakraborty, S., Cole, N., Delavy, M., Kosmala, D., Marsaux, B., Fróis-Martins, R., Morelli, M., Rosati, D., Valentine, M., Xie, Z., Emritloll, Y., Warn, P.A., Bequet, F., Bougnoux, M.E., Bornes, S., Gresnigt, M.S., Hube, B., Jacobsen, I.D., Legrand, M., Leibundgut-Landmann, S., Manichanh, C., Munro, C.A., Netea, M.G., Queiroz, K., Roget, K., Thomas, V., Thoral, C., Abbeele, P. Van den, Walker, A.W., Brown, A.J., D'Enfert, C., Kaune, A.K., Alaban, L.R., Chakraborty, S., Cole, N., Delavy, M., Kosmala, D., Marsaux, B., Fróis-Martins, R., Morelli, M., Rosati, D., Valentine, M., Xie, Z., Emritloll, Y., Warn, P.A., Bequet, F., Bougnoux, M.E., Bornes, S., Gresnigt, M.S., Hube, B., Jacobsen, I.D., Legrand, M., Leibundgut-Landmann, S., Manichanh, C., Munro, C.A., Netea, M.G., Queiroz, K., Roget, K., Thomas, V., Thoral, C., Abbeele, P. Van den, Walker, A.W., and Brown, A.J.
- Abstract
Contains fulltext : 235356.pdf (Publisher’s version ) (Open Access), Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial barriers and immune defences. Their perturbation can lead to fungal outgrowth and the development of mucosal infections such as oropharyngeal or vulvovaginal candidiasis, and patients with compromised immunity are susceptible to life-threatening systemic infections. The importance of the interplay between fungus, host and microbiota in driving the transition from C. albicans commensalism to pathogenicity is widely appreciated. However, the complexity of these interactions, and the significant impact of fungal, host and microbiota variability upon disease severity and outcome, are less well understood. Therefore, we summarise the features of the fungus that promote infection, and how genetic variation between clinical isolates influences pathogenicity. We discuss antifungal immunity, how this differs between mucosae, and how individual variation influences a person's susceptibility to infection. Also, we describe factors that influence the composition of gut, oral and vaginal microbiotas, and how these affect fungal colonisation and antifungal immunity. We argue that a detailed understanding of these variables, which underlie fungal-host-microbiota interactions, will present opportunities for directed antifungal therapies that benefit vulnerable patients.
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- 2021
86. Lésions d’ischémie-reperfusion rénale
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Delattre, R. and Legrand, M.
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- 2012
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87. Simultaneous assessment of peak-locking and CCD readout errors through a multiple Δt strategy
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Legrand, M., Nogueira, J., Ventas, R., and Lecuona, A.
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- 2012
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88. Quantitative evaluation of PIV peak locking through a multiple Δt strategy: relevance of the rms component
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Nogueira, J., Lecuona, A., Nauri, S., Legrand, M., and Rodríguez, P. A.
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- 2011
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89. High right atrial pressure is associated with worsening renal function in acute decompensated heart failure: review of 33 studies with hemodynamic evaluation: 100
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Ishihara, S, Gayat, E, Laribi, S, Legrand, M, Sato, N, Cohen-Solal, A, and Mebazaa, A
- Published
- 2014
90. Causes of Enhanced Bromine Levels in Alpine Ice Cores During the 20th Century: Implications for Bromine in the Free European Troposphere
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Legrand, M., primary, McConnell, J. R., additional, Preunkert, S., additional, Chellman, N. J., additional, and Arienzo, M. M., additional
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- 2021
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91. Regional Characteristics of Atmospheric Sulfate Formation in East Antarctica Imprinted on 17 O‐Excess Signature
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Ishino, S., primary, Hattori, S., additional, Legrand, M., additional, Chen, Q., additional, Alexander, B., additional, Shao, J., additional, Huang, J., additional, Jaeglé, L., additional, Jourdain, B., additional, Preunkert, S., additional, Yamada, A., additional, Yoshida, N., additional, and Savarino, J., additional
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- 2021
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92. Cycloaffaiblisement au laser diode micropulsé : une technique efficace, mais dont la stratégie reste à définir
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Maestri, F., primary, Legrand, M., additional, Da Cunha, E., additional, Best, A.-L., additional, Benichou, J., additional, Barreau, E., additional, Labetoulle, M., additional, and Rousseau, A., additional
- Published
- 2021
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93. Place du NIBUT automatisé dans l’évaluation multimodale de la surface oculaire dans le syndrome sec avec le Lacrydiag
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Remongin, P.-E., primary, Rousseau, A., additional, Best, A.-L., additional, Ben Hadj Salah, W., additional, Legrand, M., additional, Benichou, J., additional, Barreau, E., additional, and Labetoulle, M., additional
- Published
- 2021
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94. 4D Photoluminescence Imaging for Advanced Characterization of Photovoltaic Absorber
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Legrand, M., Bercegol, A., Duchatelet, A., Lombez, L., Guillemoles, J.-F., and Ory, D.
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Fundamental Studies ,New Materials and Concepts for Photovoltaic Devices - Abstract
37th European Photovoltaic Solar Energy Conference and Exhibition; 9-12, In this work, we present the principle of a new multidimensional photoluminescence imaging set-up allowing the extraction of carriers recombination and transport properties. For this purpose, the reconstruction of spatial information from non-imaging detector is performed by Single Pixel Imaging, an approach based on light modulation. In that way, we built a hyperspectral imager from a spectrometer in parallel with a time-resolved imaging branch. We demonstrate the use of this set-up to study light-soaking of halide perovskite. Indeed, the illumination induces both changes in the spectrum and in the photoluminescence dynamic as illustrated in the literature. These two measures are complementary and investigate a wide range of characteristics of the sample as its optical, transport and electronic properties. They offer together a valuable feedback in order to elaborate new performant and innovative materials for photovoltaics. This set-up constitutes a first step toward a 4D-PL imaging based on single pixel imaging providing the local temporal evolution of the sample spectrum.
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- 2020
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95. Prix SFAR 2020 : « Ils ont fait avancer la recherche en anesthésie-réanimation » : Professeur Didier Payen = SFAR 2020 awards: 'They contributed to the research in anaesthesia and critical care': Professor Didier Payen
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Lukaszewicz, AC, Gattinoni, L, Ince, Can, Monneret, G, Legrand, M, Losser, MR, and Intensive Care
- Published
- 2020
96. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup
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Nadim, M.K., Forni, L.G., Mehta, R.L., Connor, M.J., Jr., Liu, K.D., Ostermann, M., Rimmelé, T., Zarbock, A., Bell, S., Bihorac, A., Cantaluppi, V., Hoste, E., Husain-Syed, F., Germain, M.J., Goldstein, S.L., Gupta, S., Joannidis, M., Kashani, K., Koyner, J.L., Legrand, M., Lumlertgul, N., Mohan, S., Pannu, N., Peng, Z., Perez-Fernandez, X.L., Pickkers, P., Prowle, J., Reis, T., Srisawat, N., Tolwani, A., Vijayan, A., Villa, G., Yang, L., Ronco, C., Kellum, J.A., Nadim, M.K., Forni, L.G., Mehta, R.L., Connor, M.J., Jr., Liu, K.D., Ostermann, M., Rimmelé, T., Zarbock, A., Bell, S., Bihorac, A., Cantaluppi, V., Hoste, E., Husain-Syed, F., Germain, M.J., Goldstein, S.L., Gupta, S., Joannidis, M., Kashani, K., Koyner, J.L., Legrand, M., Lumlertgul, N., Mohan, S., Pannu, N., Peng, Z., Perez-Fernandez, X.L., Pickkers, P., Prowle, J., Reis, T., Srisawat, N., Tolwani, A., Vijayan, A., Villa, G., Yang, L., Ronco, C., and Kellum, J.A.
- Abstract
Contains fulltext : 229377.pdf (Publisher’s version ) (Open Access), Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) requiring renal replacement therapy (RRT; also known as kidney replacement therapy). COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and serves as an independent risk factor for all-cause in-hospital death in patients with COVID-19. The pathophysiology and mechanisms of AKI in patients with COVID-19 have not been fully elucidated and seem to be multifactorial, in keeping with the pathophysiology of AKI in other patients who are critically ill. Little is known about the prevention and management of COVID-19 AKI. The emergence of regional 'surges' in COVID-19 cases can limit hospital resources, including dialysis availability and supplies; thus, careful daily assessment of available resources is needed. In this Consensus Statement, the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI based on current literature. We also make recommendations for areas of future research, which are aimed at improving understanding of the underlying processes and improving outcomes for patients with COVID-19 AKI.
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- 2020
97. Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury
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Khorashadi, Mina, Beunders, R., Pickkers, P., Legrand, M., Khorashadi, Mina, Beunders, R., Pickkers, P., and Legrand, M.
- Abstract
Contains fulltext : 228565.pdf (Publisher’s version ) (Open Access)
- Published
- 2020
98. Long-Term Climatic and Environmental Records from Antarctic Ice
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Lorius, C., primary, Barnola, J-M., additional, Legrand, M., additional, Petit, J. R., additional, Raynaud, D., additional, Ritz, C., additional, Barkov, N., additional, Korotkevich, Y. S., additional, Petrov, V. N., additional, Genthon, C., additional, Jouzel, J., additional, Kotlyakov, V. M., additional, Yiou, F., additional, and Raisbeck, G., additional
- Published
- 2013
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99. Greenland records of aerosol source and atmospheric lifetime changes from the Eemian to the Holocene
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Schüpbach, S., Fischer, H., Bigler, M., Erhardt, T., Gfeller, G., Leuenberger, D., Mini, O., Mulvaney, R., Abram, N. J., Fleet, L., Frey, M. M., Thomas, E., Svensson, A., Dahl-Jensen, D., Kettner, E., Kjaer, H., Seierstad, I., Steffensen, J. P., Rasmussen, S. O., Vallelonga, P., Winstrup, M., Wegner, Anna, Twarloh, Birthe, Wolff, Katrin, Schmidt, Kerstin, Goto-Azuma, K., Kuramoto, T., Hirabayashi, M., Uetake, J., Zheng, J., Bourgeois, J., Fisher, D., Zhiheng, D., Xiao, C., Legrand, M., Spolaor, A., Gabrieli, J., Barbante, C., Kang, J.-H., Hur, S. D., Hong, S. B., Hwang, H. J., Hong, S., Hansson, M., Iizuka, Y., Oyabu, I., Muscheler, R., Adolphi, F., Maselli, O., McConnell, J., Wolff, E. W., Fischer, H [0000-0002-2787-4221], Mulvaney, R [0000-0002-5372-8148], Abram, NJ [0000-0003-1246-2344], Thomas, E [0000-0002-3010-6493], Svensson, A [0000-0002-4364-6085], Kjaer, H [0000-0002-3781-9509], Vallelonga, P [0000-0003-1055-7235], Goto-Azuma, K [0000-0003-0992-1079], Spolaor, A [0000-0001-8635-9193], Adolphi, F [0000-0003-0014-8753], Wolff, EW [0000-0002-5914-8531], and Apollo - University of Cambridge Repository
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530 Physics ,Science ,fungi ,respiratory system ,palaeoclimate ,complex mixtures ,Article ,biogeochemistry ,atmospheric science ,lcsh:Q ,sense organs ,lcsh:Science ,skin and connective tissue diseases - Abstract
The Northern Hemisphere experienced dramatic changes during the last glacial, featuring vast ice sheets and abrupt climate events, while high northern latitudes during the last interglacial (Eemian) were warmer than today. Here we use high-resolution aerosol records from the Greenland NEEM ice core to reconstruct the environmental alterations in aerosol source regions accompanying these changes. Separating source and transport effects, we find strongly reduced terrestrial biogenic emissions during glacial times reflecting net loss of vegetated area in North America. Rapid climate changes during the glacial have little effect on terrestrial biogenic aerosol emissions. A strong increase in terrestrial dust emissions during the coldest intervals indicates higher aridity and dust storm activity in East Asian deserts. Glacial sea salt aerosol emissions in the North Atlantic region increase only moderately (50%), likely due to sea ice expansion. Lower aerosol concentrations in Eemian ice compared to the Holocene are mainly due to shortened atmospheric residence time, while emissions changed little., Past climate changes in Greenland ice were accompanied by large aerosol concentration changes. Here, the authors show that by correcting for transport effects, reliable source changes for biogenic aerosol from North America, sea salt aerosol from the North Atlantic, and dust from East Asian deserts can be derived.
- Published
- 2018
100. Une maladie systémique mimant une polyarthrite rhumatoïde
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Legrand, M., Nouvier, M., Paulin, L., Deschamps, B., Pialat, J.B., and Coury, F.
- Published
- 2019
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