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72. A comprehensive fracture prevention strategy in older adults : The European union geriatric medicine society (EUGMS) statement

Author

Blain, H., Masud, T., Dargent-Molina, P., Martin, F. C., Rosendahl, E., van der Velde, N., Bousquet, J., Benetos, A., Cooper, C., Kanis, J. A., Reginster, J. Y., Rizzoli, R., Cortet, B., Barbagallo, M., Dreinhöfer, K., Vellas, B., Maggi, S., Strandberg, T., Alvarez, M. N., Annweiler, C., Bernard, P. L., Beswetherick, N., Bischoff-Ferrari, H. A., Bloch, F., Boddaert, J., Bonnefoy, M., Bousson, V., Bourdel-Marchasson, I., Capisizu, A., Che, H., Clara, J. G., Combe, B., Delignieres, D., Eklund, P., Emmelot-Vonk, M., Freiberger, E., Gauvain, J. B., Goswami, N., Guldemond, N., Herrero, C., Joël, M. E., Jónsdóttir, A. B., Kemoun, G., Kiss, I., Kolk, H., Kowalski, M. L., Krajcík, Kutsal, Y. G., Lauretani, F., Macijauskienė, J., Mellingsæter, M., Morel, J., Mourey, F., Nourashemi, F., Nyakas, C., Puisieux, F., Rambourg, P., Ramírez, A. G., Rapp, K., Rolland, Y., Ryg, J., Sahota, O., Snoeijs, S., Stephan, Y., Thomas, E., Todd, C., Treml, J., Adachi, R., Agnusdei, D., Body, J. J., Breuil, V., Bruyère, O., Burckardt, P., Cannata-Andia, J. B., Carey, J., Chan, D. C., Chapuis, L., Chevalley, T., Cohen-Solal, M., Dawson-Hughes, B., Dennison, E. M., Devogelaer, J. P., Fardellone, P., Féron, J. M., Perez, A. D., Felsenberg, D., Glueer, C., Harvey, N., Hiligsman, M., Javaid, M. K., Jörgensen, N. R., Kendler, D., Kraenzlin, M., Laroche, M., Legrand, E., Leslie, W. D., Lespessailles, E., Lewiecki, E. M., Nakamura, T., Papaioannou, A., Roux, C., Silverman, S., Henriquez, M. S., Thomas, T., Vasikaran, S., Watts, N. B., and Weryha, G.

Subjects
Prevention, Falls, Position statement, Older people, Geriatrics and Gerontology, Fragility fracture, Gerontology
Abstract

Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest group on falls and fracture prevention of the European union geriatric medicine society (EUGMS), in collaboration with the International association of gerontology and geriatrics for the European region (IAGG-ER), the European union of medical specialists (EUMS), the Fragility fracture network (FFN), the International osteoporosis foundation (IOF) – European society for clinical and economic aspects of osteoporosis and osteoarthritis (ECCEO), outlines its views on the main points in the current debate in relation to the primary and secondary prevention of falls, the diagnosis and treatment of bone fragility, and the place of combined falls and fracture liaison services for fracture prevention in older people.

Published
2016

81. A comprehensive fracture prevention strategy in older adults: The European union geriatric medicine society (EUGMS) statement

Author

Blain, H., primary, Masud, T., additional, Dargent-Molina, P., additional, Martin, F.C., additional, Rosendahl, E., additional, van der Velde, N., additional, Bousquet, J., additional, Benetos, A., additional, Cooper, C., additional, Kanis, J.A., additional, Reginster, J.Y., additional, Rizzoli, R., additional, Cortet, B., additional, Barbagallo, M., additional, Dreinhöfer, K., additional, Vellas, B., additional, Maggi, S., additional, Strandberg, T., additional, Alvarez, M.N., additional, Annweiler, C., additional, Bernard, P.-L., additional, Beswetherick, N., additional, Bischoff-Ferrari, H.A., additional, Bloch, F., additional, Boddaert, J., additional, Bonnefoy, M., additional, Bousson, V., additional, Bourdel-Marchasson, I., additional, Capisizu, A., additional, Che, H., additional, Clara, J.G., additional, Combe, B., additional, Delignieres, D., additional, Eklund, P., additional, Emmelot-Vonk, M., additional, Freiberger, E., additional, Gauvain, J.-B., additional, Goswami, N., additional, Guldemond, N., additional, Herrero, Á.C., additional, Joël, M.-E., additional, Jónsdóttir, A.B., additional, Kemoun, G., additional, Kiss, I., additional, Kolk, H., additional, Kowalski, M.L., additional, Krajcík, Š., additional, Kutsal, Y.G., additional, Lauretani, F., additional, Macijauskienė, J., additional, Mellingsæter, M., additional, Morel, J., additional, Mourey, F., additional, Nourashemi, F., additional, Nyakas, C., additional, Puisieux, F., additional, Rambourg, P., additional, Ramírez, A.G., additional, Rapp, K., additional, Rolland, Y., additional, Ryg, J., additional, Sahota, O., additional, Snoeijs, S., additional, Stephan, Y., additional, Thomas, E., additional, Todd, C., additional, Treml, J., additional, Adachi, R., additional, Agnusdei, D., additional, Body, J.-J., additional, Breuil, V., additional, Bruyère, O., additional, Burckardt, P., additional, Cannata-Andia, J.B., additional, Carey, J., additional, Chan, D.-C., additional, Chapuis, L., additional, Chevalley, T., additional, Cohen-Solal, M., additional, Dawson-Hughes, B., additional, Dennison, E.M., additional, Devogelaer, J.-P., additional, Fardellone, P., additional, Féron, J.-M., additional, Perez, A.D., additional, Felsenberg, D., additional, Glueer, C., additional, Harvey, N., additional, Hiligsman, M., additional, Javaid, M.K., additional, Jörgensen, N.R., additional, Kendler, D., additional, Kraenzlin, M., additional, Laroche, M., additional, Legrand, E., additional, Leslie, W.D., additional, Lespessailles, E., additional, Lewiecki, E.M., additional, Nakamura, T., additional, Papaioannou, A., additional, Roux, C., additional, Silverman, S., additional, Henriquez, M.S., additional, Thomas, T., additional, Vasikaran, S., additional, Watts, N.B., additional, and Weryha, G., additional

Published
2016
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83. A comprehensive fracture prevention strategy in older adults: The European union geriatric medicine society (EUGMS) statement

Author

MS Geriatrie, Circulatory Health, Blain, H., Masud, T., Dargent-Molina, P., Martin, F. C., Rosendahl, E., van der Velde, N., Bousquet, J., Benetos, A., Cooper, C., Kanis, J. A., Reginster, J. Y., Rizzoli, R., Cortet, B., Barbagallo, M., Dreinhöfer, K., Vellas, B., Maggi, S., Strandberg, T., Alvarez, M. N., Annweiler, C., Bernard, P. L., Beswetherick, N., Bischoff-Ferrari, H. A., Bloch, F., Boddaert, J., Bonnefoy, M., Bousson, V., Bourdel-Marchasson, I., Capisizu, A., Che, H., Clara, J. G., Combe, B., Delignieres, D., Eklund, P., Emmelot-Vonk, M., Freiberger, E., Gauvain, J. B., Goswami, N., Guldemond, N., Herrero, C., Joël, M. E., Jónsdóttir, A. B., Kemoun, G., Kiss, I., Kolk, H., Kowalski, M. L., Krajcík, Kutsal, Y. G., Lauretani, F., Macijauskienė, J., Mellingsæter, M., Morel, J., Mourey, F., Nourashemi, F., Nyakas, C., Puisieux, F., Rambourg, P., Ramírez, A. G., Rapp, K., Rolland, Y., Ryg, J., Sahota, O., Snoeijs, S., Stephan, Y., Thomas, E., Todd, C., Treml, J., Adachi, R., Agnusdei, D., Body, J. J., Breuil, V., Bruyère, O., Burckardt, P., Cannata-Andia, J. B., Carey, J., Chan, D. C., Chapuis, L., Chevalley, T., Cohen-Solal, M., Dawson-Hughes, B., Dennison, E. M., Devogelaer, J. P., Fardellone, P., Féron, J. M., Perez, A. D., Felsenberg, D., Glueer, C., Harvey, N., Hiligsman, M., Javaid, M. K., Jörgensen, N. R., Kendler, D., Kraenzlin, M., Laroche, M., Legrand, E., Leslie, W. D., Lespessailles, E., Lewiecki, E. M., Nakamura, T., Papaioannou, A., Roux, C., Silverman, S., Henriquez, M. S., Thomas, T., Vasikaran, S., Watts, N. B., Weryha, G., MS Geriatrie, Circulatory Health, Blain, H., Masud, T., Dargent-Molina, P., Martin, F. C., Rosendahl, E., van der Velde, N., Bousquet, J., Benetos, A., Cooper, C., Kanis, J. A., Reginster, J. Y., Rizzoli, R., Cortet, B., Barbagallo, M., Dreinhöfer, K., Vellas, B., Maggi, S., Strandberg, T., Alvarez, M. N., Annweiler, C., Bernard, P. L., Beswetherick, N., Bischoff-Ferrari, H. A., Bloch, F., Boddaert, J., Bonnefoy, M., Bousson, V., Bourdel-Marchasson, I., Capisizu, A., Che, H., Clara, J. G., Combe, B., Delignieres, D., Eklund, P., Emmelot-Vonk, M., Freiberger, E., Gauvain, J. B., Goswami, N., Guldemond, N., Herrero, C., Joël, M. E., Jónsdóttir, A. B., Kemoun, G., Kiss, I., Kolk, H., Kowalski, M. L., Krajcík, Kutsal, Y. G., Lauretani, F., Macijauskienė, J., Mellingsæter, M., Morel, J., Mourey, F., Nourashemi, F., Nyakas, C., Puisieux, F., Rambourg, P., Ramírez, A. G., Rapp, K., Rolland, Y., Ryg, J., Sahota, O., Snoeijs, S., Stephan, Y., Thomas, E., Todd, C., Treml, J., Adachi, R., Agnusdei, D., Body, J. J., Breuil, V., Bruyère, O., Burckardt, P., Cannata-Andia, J. B., Carey, J., Chan, D. C., Chapuis, L., Chevalley, T., Cohen-Solal, M., Dawson-Hughes, B., Dennison, E. M., Devogelaer, J. P., Fardellone, P., Féron, J. M., Perez, A. D., Felsenberg, D., Glueer, C., Harvey, N., Hiligsman, M., Javaid, M. K., Jörgensen, N. R., Kendler, D., Kraenzlin, M., Laroche, M., Legrand, E., Leslie, W. D., Lespessailles, E., Lewiecki, E. M., Nakamura, T., Papaioannou, A., Roux, C., Silverman, S., Henriquez, M. S., Thomas, T., Vasikaran, S., Watts, N. B., and Weryha, G.

Published
2016

91. What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?

Author

Schneider, P., Dubus, I., Gouel, F., Legrand, E., Vannier, J. P., and Vasse, M.

Subjects
Article Subject
Abstract

The role of angiogenesis in acute leukaemia has been discussed since the cloning of the gene of vascular endothelial growth factor (VEGF) from the acute myelogenous leukemia cell line (HL60) and, thereafter, when the first studies reported increased bone marrow vascularity and elevation of angiogenic cytokines in acute lymphoblastic leukaemia (ALL). VEGF and basic fibroblast growth factor (bFGF) are the major proangiogenic cytokines that have been studied, and evaluation of their prognostic impact in childhood ALL has been reported in several studies, though with controversial results. The antiangiogenic response, contributing to the angiogenic balance, has scarcely been reported. The origin of the factors, their prognostic value, and their relevance as good markers of what really happens in the bone marrow are discussed in this paper. The place of antiangiogenic drugs in ALL has to be defined in the global treatment strategy.

Published
2011
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92. Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance

Author

Piot, J M, primary, Royer, M, additional, Schmidt-Tanguy, A, additional, Hoppé, E, additional, Gardembas, M, additional, Bourrée, T, additional, Hunault, M, additional, François, S, additional, Boyer, F, additional, Ifrah, N, additional, Renier, G, additional, Chevailler, A, additional, Audran, M, additional, Chappard, D, additional, Libouban, H, additional, Mabilleau, G, additional, Legrand, E, additional, and Bouvard, B, additional

Published
2015
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93. Facteurs de risque psychosociaux de passage à la chronicité des lombalgies, repérables en soins primaires - Revue de la littérature

Author

Ramond-Roquin, Aline, Bouton, Céline, Richard, Isabelle, Roquelaure, Yves, Baufreton, Christophe, Legrand, E, Huez, Jean-François, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Rubion, Elise

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

94. Effects of Mefloquine Use on Plasmodium vivax Multidrug Resistance

Author

Khim, N, Andrianaranjaka, V, Popovici, J, Kim, S, Ratsimbasoa, A, Benedet, C, Barnadas, C, Durand, R, Thellier, M, Legrand, E, Musset, L, Menegon, M, Severini, C, Nour, BYM, Tichit, M, Bouchier, C, Mercereau-Puijalon, O, Menard, D, Khim, N, Andrianaranjaka, V, Popovici, J, Kim, S, Ratsimbasoa, A, Benedet, C, Barnadas, C, Durand, R, Thellier, M, Legrand, E, Musset, L, Menegon, M, Severini, C, Nour, BYM, Tichit, M, Bouchier, C, Mercereau-Puijalon, O, and Menard, D

Abstract

Numerous studies have indicated a strong association between amplification of the multidrug resistance-1 gene and in vivo and in vitro mefloquine resistance of Plasmodium falciparum. Although falciparum infection usually is not treated with mefloquine, incorrect diagnosis, high frequency of undetected mixed infections, or relapses of P. vivax infection triggered by P. falciparum infections expose non-P. falciparum parasites to mefloquine. To assess the consequences of such unintentional treatments on P. vivax, we studied variations in number of Pvmdr-1 (PlasmoDB accession no. PVX_080100, NCBI reference sequence NC_009915.1) copies worldwide in 607 samples collected in areas with different histories of mefloquine use from residents and from travelers returning to France. Number of Pvmdr-1 copies correlated with drug use history. Treatment against P. falciparum exerts substantial collateral pressure against sympatric P. vivax, jeopardizing future use of mefloquine against P. vivax. A drug policy is needed that takes into consideration all co-endemic species of malaria parasites.

Published
2014

97. Response to comments on “Computational analysis of geometrical factors affecting experimental data extracted from hydrogen permeation test: I – Consequences of trapping” [Int J Hydrogen Energy 36 (2011) 12644–12652] and “II – Consequences of trapping and an oxide layer” [Int J Hydrogen Energy 37 (2012) 13574–13582], “Corrigenda” to both [Int J Hydrogen Energy 39 (2014) 2430], and on “III – Comparison with experimental results from the literature” [Int J Hydrogen Energy 39 (2014) 1145–1155] with “Generalized model of desorption kinetics: Characterization of hydrogen trapping in a homogeneous membrane” [Int J Hydrogen Energy 39 (2014) 8374–8384]

Author

Legrand, E., primary, Bouhattate, J., additional, Oudriss, A., additional, Frappart, S., additional, Creus, J., additional, Feaugas, X., additional, and Garmestani, H., additional

Published
2014
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98. Formation et esprit d'entreprendre chez les étudiants

Author

Branchet, B., Boissin, J.P., Casagrande, Annette, Arlotto, J., Cesar, M., Dervaux, C., Legrand, E., Tremenbert, P., Lucatello, Coralie, Centre d'études et de recherches appliquées à la gestion (CERAG), and Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)

Subjects
domaine d'étude, esprit d'entreprendre,domaine d'étude,étudiants français, [SHS.GESTION]Humanities and Social Sciences/Business administration, esprit d'entreprendre, [SHS.GESTION] Humanities and Social Sciences/Business administration, étudiants français
Abstract

cahier de recherche n°2009-17 E4; Cette contribution s'attache à étudier entre esprit d'entreprendre et domaine d'études chez les étudiants français. L'esprit d'entreprendre est le substrat dans lequel peut germer l'intention qui pourra donner lieu à une création d'entreprise. Nous choisissons de l'appréhender à partir d'une grille de lecture dérivée du modèle psychosocial du comportement planifié d'Ajzen, enrichie par des variables reflétant l'implication dans la vie associative et les opinions sur les formations à la création d'entreprise.

Published
2009

99. A new leukemogenic retrovirus isolated from tumor cells derived from a radio-induced lymphoma of C57BL/6 mice: analysis of the env and LTR sequences

Author

R. Mamoun, T. Astier-Gin, M. Hernould, H. Baylac-Kalabokias, Legrand E, Daniel Moynet, and B. Guillemain

Subjects
Cancer Research, Neoplasms, Radiation-Induced, Lymphoma, viruses, Molecular Sequence Data, Restriction Mapping, Endogenous retrovirus, Transfection, medicine.disease_cause, Genes, env, Virus, Leukemogenic, Mice, Retrovirus, Proviruses, Viral Envelope Proteins, Sequence Homology, Nucleic Acid, Virology, Consensus Sequence, Consensus sequence, medicine, Animals, Amino Acid Sequence, Cloning, Molecular, Repetitive Sequences, Nucleic Acid, Mutation, Base Sequence, biology, Provirus, biology.organism_classification, Mice, Inbred C57BL, Enhancer Elements, Genetic, Retroviridae, Infectious Diseases
Abstract

We report the cloning and characterization of a new ecotropic provirus encountered in a radio-induced thymic lymphoma of the C57BL/6 mouse. The provirus with an abnormally long LTR was inserted in the chromosomal DNA within the Pvt-1/MLVi-1/Mis-1 region which is a common integration site for MCF virus in mice and for Mo-MuLV in rats. This new ecotropic provirus was molecularly cloned and found to be infectious and competent for replication after transfection of murine cells. The recovered virus termed T3651/B was B-ecotropic, T-lymphotropic (in vivo) and highly leukemogenic for newborn C57BL/6 mice and for adult mice provided they were submitted to a subleukemogenic dose of irradiation. As compared to the AKV prototype N-ecotropic endogenous retrovirus, the T3651/B env proteins are only affected by few scattered point mutations. In contrast, the LTR has five repeats of enhancer sequences containing consensus motifs specific of the nuclear factors NF1-like, LVa, LVb and SEF1. Since a virus with such properties was encountered only once in 31 radio-induced tumors and isolated at a fourth tumor passage, a direct role of T3651/B virus in tumor genesis after irradiation is uncertain. Nevertheless, it is clear that T3651/B virus is a new leukemogenic retrovirus with a particular LTR structure which fits well with the model proposed by Rassart et al. (J. Virol. 58, 96-106, 1986) for the emergence of a thymotropic highly leukemogenic RadLV.

Published
1991

100. Ostéomalacie oncogénique : une maladie ou la scintigraphie est déterminante

Author

Jeanguillaume, Christian, Metrard, Gilles, Rakotonirina, H., Legrand, E., Scarwell, B., Morel, O., Berthelot, C., Bouchet, F., Le Jeune, J.-J., Giraud, Stéphane, Laboratoire d'Ingéniérie des Systèmes Automatisés (LISA), Université d'Angers (UA), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Homéostasie Cellulaire et Pathologies (HCP), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), and Gerard, Marie-Françoise

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2008

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