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3,982 results on '"Lee, Seung Jae"'

66. Conformation-specific Antibodies Targeting Aggregated Forms of α-synuclein Block the Propagation of Synucleinopathy.

Author

Choi, Minsun, Kim, Tae-Kyung, Ahn, Jinhyung, Lee, Jun, Jung, Byung, An, Sungwon, Kim, Dongin, Lee, Min, Mook-Jung, Inhee, Lee, Sang, and Lee, Seung-Jae

Subjects
Immunotherapy, Microglia, Parkinson’s disease, Synuclein
Abstract

Abnormal aggregation of α-synuclein is a key element in the pathogenesis of several neurodegenerative diseases, including Parkinsons disease (PD), dementia with Lewy bodies, and multiple system atrophy. α-synuclein aggregation spreads through various brain regions during the course of disease progression, a propagation that is thought to be mediated by the secretion and subsequent uptake of extracellular α-synuclein aggregates between neuronal cells. Thus, aggregated forms of this protein have emerged as promising targets for disease-modifying therapy for PD and related diseases. Here, we generated and characterized conformation-specific antibodies that preferentially recognize aggregated forms of α-synuclein. These antibodies promoted phagocytosis of extracellular α-synuclein aggregates by microglial cells and interfered with cell-to-cell propagation of α-synuclein. In an α-synuclein transgenic model, passive immunization with aggregate-specific antibodies significantly ameliorated pathological phenotypes, reducing α-synuclein aggregation, gliosis, inflammation, and neuronal loss. These results suggest that conformation-specific antibodies targeting α-synuclein aggregates are promising therapeutic agents for PD and related synucleinopathies.

Published
2022

67. Autonomous Flight through Cluttered Outdoor Environments Using a Memoryless Planner

Author

Lee, Junseok, Wu, Xiangyu, Lee, Seung Jae, and Mueller, Mark W.

Subjects
Computer Science - Robotics
Abstract

This paper introduces a collision avoidance system for navigating a multicopter in cluttered outdoor environments based on the recent memory-less motion planner, rectangular pyramid partitioning using integrated depth sensors (RAPPIDS). The RAPPIDS motion planner generates collision-free flight trajectories at high speed with low computational cost using only the latest depth image. In this work we extend it to improve the performance of the planner by taking the following issues into account. (a) Changes in the dynamic characteristics of the multicopter that occur during flight, such as changes in motor input/output characteristics due to battery voltage drop. (b) The noise of the flight sensor, which can cause unwanted control input components. (c) Planner utility function which may not be suitable for the cluttered environment. Therefore, in this paper we introduce solutions to each of the above problems and propose a system for the successful operation of the RAPPIDS planner in an outdoor cluttered flight environment. At the end of the paper, we validate the proposed method's effectiveness by presenting the flight experiment results in a forest environment. A video can be found at www.youtube.com/channel/UCK-gErmvZlBODN5gQpNcpsg

Published
2021

68. Cost-Effectiveness of Intravascular Imaging-Guided Complex PCI: Prespecified Analysis of RENOVATE-COMPLEX-PCI Trial

Author

Hong, David, Lee, Jin, Lee, Hankil, Cho, Juhee, Guallar, Eliseo, Choi, Ki Hong, Lee, Seung Hun, Shin, Doosup, Lee, Jong-Young, Lee, Seung-Jae, Lee, Sang Yeub, Kim, Sang Min, Yun, Kyeong Ho, Cho, Jae Young, Kim, Chan Joon, Ahn, Hyo-Suk, Nam, Chang-Wook, Yoon, Hyuck-Jun, Park, Yong Hwan, Lee, Wang Soo, Park, Taek Kyu, Yang, Jeong Hoon, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, Song, Young Bin, Hahn, Joo-Yong, Kang, Danbee, and Lee, Joo Myung

Published
2024
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69. Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations.

Author

Jo, Junghyun, Yang, Lin, Tran, Hoang-Dai, Yu, Weonjin, Sun, Alfred, Chang, Ya, Jung, Byung, Lee, Seung-Jae, Saw, Tzuen, Xiao, Bin, Khoo, Audrey, Yaw, Lai-Ping, Xie, Jessica, Lokman, Hidayat, Ong, Wei-Yi, Lim, Grace, Lim, Kah-Leong, Tan, Eng-King, Ng, Huck-Hui, and Je, Hyunsoo

Subjects
Embryonic Stem Cells, Glucosylceramidase, Humans, Lewy Bodies, Mesencephalon, Mutation, Organoids, alpha-Synuclein
Abstract

OBJECTIVE: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parkinson disease, with the particular aim of recapitulating α-syn- and Lewy body-related pathologies and the process of neurodegeneration in the hMLO model. METHODS: We generated and characterized hMLOs from GBA1-/- and SNCA overexpressing isogenic embryonic stem cells and also generated Lewy body-like inclusions in GBA1/SNCA dual perturbation hMLOs and conduritol-b-epoxide-treated SNCA triplication hMLOs. RESULTS: We identified for the first time that the loss of glucocerebrosidase, coupled with wild-type α-syn overexpression, results in a substantial accumulation of detergent-resistant, β-sheet-rich α-syn aggregates and Lewy body-like inclusions in hMLOs. These Lewy body-like inclusions exhibit a spherically symmetric morphology with an eosinophilic core, containing α-syn with ubiquitin, and can also be formed in Parkinson disease patient-derived hMLOs. We also demonstrate that impaired glucocerebrosidase function promotes the formation of Lewy body-like inclusions in hMLOs derived from patients carrying the SNCA triplication. INTERPRETATION: Taken together, the data indicate that our hMLOs harboring 2 major risk factors (glucocerebrosidase deficiency and wild-type α-syn overproduction) of Parkinson disease provide a tractable model to further elucidate the underlying mechanisms for progressive Lewy body formation. ANN NEUROL 2021;90:490-505.

Published
2021

71. Intravascular Imaging-Guided Percutaneous Coronary Intervention Before and After Standardized Optimization Protocols

Author

Kwon, Woochan, Hong, David, Choi, Ki Hong, Lee, Seung Hun, Shin, Doosup, Lee, Jong-Young, Lee, Seung-Jae, Lee, Sang Yeub, Kim, Sang Min, Yun, Kyeong Ho, Cho, Jae Young, Kim, Chan Joon, Ahn, Hyo-Suk, Nam, Chang-Wook, Yoon, Hyuck-Jun, Park, Yong Hwan, Lee, Wang Soo, Park, Taek Kyu, Yang, Jeong Hoon, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, Song, Young Bin, Hahn, Joo-Yong, and Lee, Joo Myung

Published
2024
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78. Fail-safe Flight of a Fully-Actuated Quadcopter in a Single Motor Failure

Author

Lee, Seung Jae, Jang, Inkyu, and Kim, H. Jin

Subjects
Computer Science - Robotics
Abstract

In this paper, we introduce a new quadcopter fail-safe flight solution that can perform the same four controllable degrees-of-freedom flight as a regular multirotor even when a single thruster fails. The new solution employs a novel multirotor platform known as the T3-Multirotor and utilizes a distinctive strategy of actively controlling the center of gravity position to restore the nominal flight performance. A dedicated control structure is introduced, along with a detailed analysis of the dynamic characteristics of the platform that change during emergency flights. Experimental results are provided to validate the feasibility of the proposed fail-safe flight strategy., Comment: 8 pages, 8 figures

Published
2020

84. Clinical Benefit of Intravascular Imaging Compared With Conventional Angiography in Left Main Coronary Artery Intervention

Author

Kwon, Woochan, Lee, Joo Myung, Yun, Kyeong Ho, Choi, Ki Hong, Lee, Seung-Jae, Lee, Jong-Young, Lee, Sang Yeub, Kim, Sang Min, Cho, Jae Young, Kim, Chan Joon, Ahn, Hyo-Suk, Nam, Chang-Wook, Yoon, Hyuck-Jun, Park, Yong Hwan, Lee, Wang Soo, Jeong, Jin-Ok, Song, Pil Sang, Doh, Joon-Hyung, Jo, Sang-Ho, Yoon, Chang-Hwan, Kang, Min Gyu, Koh, Jin-Sin, Lee, Kwan Yong, Lim, Young-Hyo, Cho, Yun-Hyeong, Cho, Jin-Man, Jang, Woo Jin, Chun, Kook-Jin, Hong, David, Park, Taek Kyu, Yang, Jeong Hoon, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, Hahn, Joo-Yong, and Song, Young Bin

Published
2023
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88. Effect of inhomogeneous Dzyaloshinskii-Moriya interaction on antiferromagnetic spin-wave propagation

Author

Lee, Seung-Jae, Lee, Dong-Kyu, and Lee, Kyung-Jin

Subjects
Condensed Matter - Materials Science
Abstract

We investigate the effect of inhomogeneous Dzyaloshinskii-Moriya interaction (DMI) on antiferromagnetic spin-wave propagation theoretically and numerically. We find that antiferromagnetic spin waves can be amplified at a boundary where the DMI varies. The inhomogeneous DMI also provides a way to construct a magnonic crystal with forbidden and allowed antiferromagnetic spin-wave bands in terahertz frequency ranges. In contrast to ferromagnetic spin waves, antiferromagnetic spin waves experience a polarization-dependent phase shift when passing through the inhomogeneous DMI, offering a magnonic crystal that also serves as a spin-wave polarizer., Comment: 21 pages, 4 figures

Published
2019
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89. Robust Translational Force Control of Multi-Rotor UAV for Precise Acceleration Tracking

Author

Lee, Seung Jae, Kim, Seung Hyun, and Kim, H. Jin

Subjects
Computer Science - Robotics, Electrical Engineering and Systems Science - Systems and Control
Abstract

In this paper, we introduce a translational force control method with disturbance observer (DOB)-based force disturbance cancellation for precise three-dimensional acceleration control of a multi-rotor UAV. The acceleration control of the multi-rotor requires conversion of the desired acceleration signal to the desired roll, pitch, and total thrust. But because the attitude dynamics and the thrust dynamics are different, simple kinematic signal conversion without consideration of those difference can cause serious performance degradation in acceleration tracking. Unlike most existing translational force control techniques that are based on such simple inversion, our new method allows controlling the acceleration of the multi-rotor more precisely by considering the dynamics of the multi-rotor during the kinematic inversion. By combining the DOB with the translational force system that includes the improved conversion technique, we achieve robustness with respect to the external force disturbances that hinders the accurate acceleration control. mu-analysis is performed to ensure the robust stability of the overall closed-loop system, considering the combined effect of various possible model uncertainties. Both simulation and experiment are conducted to validate the proposed technique, which confirms the satisfactory performance to track the desired acceleration of the multi-rotor., Comment: 11 pages, 14 figures, Accepted in the T-ASE Journal on Aug. 10th, 2019

Published
2019
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90. Feature Forwarding for Efficient Single Image Dehazing

Author

Morales, Peter, Klinghoffer, Tzofi, and Lee, Seung Jae

Subjects
Computer Science - Computer Vision and Pattern Recognition, 65D19, I.4.4
Abstract

Haze degrades content and obscures information of images, which can negatively impact vision-based decision-making in real-time systems. In this paper, we propose an efficient fully convolutional neural network (CNN) image dehazing method designed to run on edge graphical processing units (GPUs). We utilize three variants of our architecture to explore the dependency of dehazed image quality on parameter count and model design. The first two variants presented, a small and big version, make use of a single efficient encoder-decoder convolutional feature extractor. The final variant utilizes a pair of encoder-decoders for atmospheric light and transmission map estimation. Each variant ends with an image refinement pyramid pooling network to form the final dehazed image. For the big variant of the single-encoder network, we demonstrate state-of-the-art performance on the NYU Depth dataset. For the small variant, we maintain competitive performance on the super-resolution O/I-HAZE datasets without the need for image cropping. Finally, we examine some challenges presented by the Dense-Haze dataset when leveraging CNN architectures for dehazing of dense haze imagery and examine the impact of loss function selection on image quality. Benchmarks are included to show the feasibility of introducing this approach into real-time systems., Comment: Accepted to the NTIRE 2019 CVPR Workshop. Paper number 77. 8 Pages

Published
2019

91. Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.

Author

Strohäker, Timo, Jung, Byung, Liou, Shu-Hao, Fernandez, Claudio, Riedel, Dietmar, Becker, Stefan, Halliday, Glenda, Bennati, Marina, Kim, Woojin, Lee, Seung-Jae, and Zweckstetter, Markus

Subjects
Aged, Aged, 80 and over, Brain, Female, Humans, Male, Models, Molecular, Multiple System Atrophy, Parkinson Disease, Protein Aggregation, Pathological, Protein Conformation, Synucleinopathies, Tissue Extracts, alpha-Synuclein
Abstract

Parkinsons disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD and MSA brain extracts and analyzed the conformational properties using fluorescent probes, NMR spectroscopy and electron paramagnetic resonance. We also generated and analyzed several in vitro α-synuclein polymorphs. We found that brain-derived α-synuclein fibrils were structurally different to all of the in vitro polymorphs analyzed. Importantly, there was a greater structural heterogeneity among α-synuclein fibrils from the PD brain compared to those from the MSA brain, possibly reflecting on the greater variability of disease phenotypes evident in PD. Our findings have significant ramifications for the use of non-brain-derived α-synuclein fibrils in PD and MSA studies, and raise important questions regarding the one disease-one strain hypothesis in the study of α-synucleinopathies.

Published
2019

99. Prognostic Impact of Intravascular Imaging–Guided Percutaneous Coronary Intervention in Chronic Total Occlusion

Author

Hong, David, Kim, Sang Min, Lee, Sang Yeub, Choi, Ki Hong, Song, Young Bin, Lee, Jong-Young, Lee, Seung-Jae, Yun, Kyeong Ho, Cho, Jae Young, Kim, Chan Joon, Ahn, Hyo-Suk, Nam, Chang-Wook, Yoon, Hyuck-Jun, Park, Yong Hwan, Lee, Wang Soo, Jeong, Jin-Ok, Song, Pil Sang, Doh, Joon-Hyung, Jo, Sang-Ho, Yoon, Chang-Hwan, Kang, Min Gyu, Koh, Jin-Sin, Lee, Kwan Yong, Lim, Young-Hyo, Cho, Yun-Hyeong, Cho, Jin-Man, Jang, Woo Jin, Chun, Kook-Jin, Park, Taek Kyu, Yang, Jeong Hoon, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, Hahn, Joo-Yong, and Lee, Joo Myung

Published
2023
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