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968 results on '"Lee, Kwang-Won"'

65. Itching and Atopy Relief using Azulene Derivatives and High-Content Ceramide Skin Barrier Nano-Liposome Structures by Dry Skin

Author

Park, Su In, Lee, Kwang Won, Park, Shinsung, and Shin, Moon Sam

Subjects
Clinical study, Guaiazulene, Ceramide, Itching relief, Cosmetics
Abstract

Atopic dermatitis (AD), a chronic inflammatory skin disease, has increased in industrialized nations, impacting approximately 15 to 20% of children and 1 to 3% of adults worldwide. Previous studies suggest that the impairment of the skin barrier and immunological dysfunction can be considered as the two main factors involved in AD. In this study, a balm formulation containing 0.02% guaiazulene, an azulene derivative, and 1.0% high-content ceramide skin barrier nano-liposome structure was developed to effectively treat AD by normalizing these main factors, and clinical trials were conducted with 23 subjects. Compared to before using the product, (1) the skin moisture content in the forearm area increased significantly (p

Published
2022

69. MiR-155-5p Elevated by Ochratoxin A Induces Intestinal Fibrosis and Epithelial-to-Mesenchymal Transition through TGF-β Regulated Signaling Pathway In Vitro and In Vivo.

Author

Rhee, Kyu Hyun, Yang, Seon Ah, Pyo, Min Cheol, Lim, Jae-Min, and Lee, Kwang-Won

Subjects
OCHRATOXINS, EPITHELIAL-mesenchymal transition, TRANSFORMING growth factors, CELLULAR signal transduction, FIBROSIS, INTESTINES
Abstract

Ochratoxin A (OTA) is a mycotoxin that induces fibrosis and epithelial-to-mesenchymal transitions (EMT) in kidneys and livers. It enters our bodies through food consumption, where it is absorbed in the intestines. However, the impact of OTA on the intestines is yet to be studied. MicroRNA (miRNAs) are small non-coding single-stranded RNAs that block the transcription of specific mRNAs and are, therefore, involved in many biochemical processes. Our findings indicate that OTA can induce EMT and intestinal fibrosis both in vivo and in vitro. This study examines the impact of OTA on intestinal toxicity and the role of miRNAs in this process. Following OTA treatment, miR-155-5p was the most elevated miRNA by next-generation sequencing. Our research showed that OTA increased miR-155-5p levels through transforming growth factor β (TGF-β), leading to the development of intestinal fibrosis and EMT. Additionally, the study identified that the modulation of TGF-β and miR-155-5p by OTA is linked to the inhibition of CCAAT/enhancer-binding protein β (C/EBPβ) and Smad2/3 accumulation in the progression of intestinal fibrosis. [ABSTRACT FROM AUTHOR]

Published
2023
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73. Lactococcus lactis KF140 Reduces Dietary Absorption of Nε - (Carboxymethyl)lysine in Rats and Humans via β-Galactosidase Activity

Author

Park, Ho-Young, primary, Lee, Hye-Bin, additional, Lee, So-Young, additional, Oh, Mi-Jin, additional, Ha, Sang Keun, additional, Do, Eunju, additional, Lee, Hyun Hee L., additional, Hur, Jinyoung, additional, Lee, Kwang-Won, additional, Nam, Mi-Hyun, additional, Park, Myoung Gyu, additional, and Kim, Yoonsook, additional

Published
2022
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76. Glyoxal-derived advanced glycation end-products, Nε-carboxymethyl-lysine, and glyoxal-derived lysine dimer induce apoptosis-related gene expression in hepatocytes.

Author

Kang, Jison, Jeong, Yu-Jin, Ha, Sang Keun, Lee, Hyun Hee, and Lee, Kwang-Won

Abstract

Background: Advanced glycation end-products (AGEs) are proteins or lipids that have been glycated nonenzymatically by reducing sugars and their derivatives such as methylglyoxal. AGEs are known to cause inflammation, oxidative stress, and diseases in the human body. The toxic effects of AGEs and their structures on the origin of the protein being modified have not been well studied. Methods and results: Five different types of AGEs: AGE1 (glucose-derived), AGE2 (glyceraldehyde-derived), AGE3 (glycolaldehyde-derived), AGE4 (methylglyoxal-derived), and AGE5 (glyoxal-derived); were used to examine the effect of AGEs on HepG2 cells. AGE2 through 5 increase the production of reactive oxygen species (ROS) in liver cells, an initiating factor for apoptosis. At the mRNA and protein levels, AGE5 treatment showed the greatest increase in expression of apoptosis-related factors such as Bax, p53, and Caspase 3. Quantitative analysis revealed that Nε-carboxymethyl-lysine (CML) and glyoxal-lysine dimer (GOLD) were the important types of AGE5. The ROS generation and the expression of apoptotic factors both increased when cells were treated with CML and GOLD. Conclusion: These findings suggest that AGE5 treatment activates the apoptosis-related gene expression in hapatocytes, with CML and GOLD as potential major AGE compounds. [ABSTRACT FROM AUTHOR]

Published
2023
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