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Introduction When a patient suffers an out-of-hospital cardiac arrest, ventilation and chest compressions are often given simultaneously during cardiopulmonary resuscitation. These simultaneous chest compressions may cause a fragmentation of the airflow, which may lead to an ineffective ventilation. This study focusses on the occurrence and quantification of this fragmentation and its effect on ventilation. Materials and methods This study is a single-center observational study, held at Ghent University Hospital. A custom-built bidirectional flow sensor was used to quantify the volumes of ventilation. Adult cardiac arrest patients who were prehospitally intubated and resuscitated by the medical emergency team were eligible for inclusion. Data of the patients who were ventilated and received simultaneous chest compressions, was used to calculate the volumes of ventilation and the amount and volumes of fragmentation. All data in this study is reported as mean (standard deviation; range). Results Data of 10 patients (7 male) with a mean age of 71 years (14;51–87) was used in this study. The mean ventilation frequency was 12/min (2;9–16), the mean minute volume and tidal volume were respectively 6.21 L (1.51;3.79–8.15) and 514 mL (99;422–682). Fragmentation of the airflow was observed in all patients, with an average of 3 (1;2–5) fragments per inspiration and a mean volume of 214 mL (65;112–341) per fragment. Discussion and conclusion Chest compressions during ventilation caused fragmentation of the airflow in all patients. There was wide variation in the number and volume of the fragments between patients. The importance of quantification of airflow volumes and the effect fragmentation of the airflow on the efficacy of ventilation can be essential in improving cardiopulmonary resuscitation techniques and therefore needs further investigation.

Purpose Inferior vena cava (IVC) filter tilt may lead to apex embedment and need for advanced retrieval techniques. This study assesses factors associated with filter tilt change over time and need for complex retrieval procedures. Materials and methods 252 consecutive patients underwent retrievable IVC filter placement and removal at a single academic institution over 58 months. 182 (72.2%) patients met inclusion criteria. IVC filters included 168 (92.3%) Gunther Tulip and 14 (7.7%) Option filters. The primary outcome was medial-to-lateral IVC filter tilt change between placement and retrieval. Secondary outcomes included advanced retrieval technique use and multiple retrieval attempts. Independent variables included demographics, IVC diameter, filter hook position relative to the renal veins, and dwell time. Associations were determined using student's t-tests, ANOVA, and linear and logistic regressions. Results Mean IVC diameter at placement was 19.2 ± 3.3 mm. Mean filter tilts at placement and retrieval were 6.1 ± 4.9° and 5.2 ± 5.0°, respectively. Mean tilt change was 5.0 ± 5.0°. Larger IVC diameter was associated with greater filter tilt change (p = 0.0004). While IVC diameter did not independently predict retrieval difficulty, greater tilt change and prolonged dwell time were associated with increased advanced retrieval technique use (p = 0.01 and 0.002, respectively). Results were unchanged in a subgroup analysis of patients treated with Gunther Tulip filters. Conclusion Larger IVC diameter predicts increased filter tilt change, which in turn is associated with challenging retrievals. Attention to IVC diameter during filter placement may anticipate tilt-related complications.

Background Although there is a paucity of contemporary data on pacemaker lead survival rates, small studies suggest that some leads may have higher malfunction rates than do others. Objective The purpose of this study was to determine the malfunction rates of current pacemaker leads. Methods A meta-analysis including studies that examined the non–implant-related lead malfunction rates of current commercially available active fixation pacemaker leads was performed. An electronic search of MEDLINE/PubMed, Scopus, and Embase was performed. DerSimonian and Laird random effects models were used. Results Eight studies with a total of 14,579 leads were included. Abbott accounted for 10,838 (74%), Medtronic 2510 (17%), Boston Scientific 849 (6%), and MicroPort 382 (3%) leads. The weighted mean follow-up period was 3.6 years. Lead abnormalities occurred in 5.0% of all leads, 6.1% of Abbott leads, 1.1% of Medtronic, 1.4% of Boston Scientific, and 5.5% of MicroPort. The most common lead abnormality was lead noise with normal impedance. Abbott leads were associated with an increased risk of abnormalities (relative risk [RR] 7.81; 95% confidence interval [CI] 3.21–19.04), reprogramming (RR 7.95; 95% CI 3.55–17.82), and lead revision or extraction (RR 8.91; 95% CI 3.36–23.60). Abbott leads connected to an Abbott generator had the highest abnormality rate (8.0%) followed by Abbott leads connected to a non-Abbott generator (4.7%) and non-Abbott leads connected to an Abbott generator (0.4%). Conclusions Abbott leads are associated with an increased risk of abnormalities compared with leads of other manufacturers, primarily manifesting as lead noise with normal impedance, and are associated with an increased risk of lead reprogramming and lead revision or extraction.

Background Obesity is associated with electrophysiological remodeling, which manifests as detectable changes on the surface electrocardiogram (ECG). Objective To develop neural networks (NN) to predict body mass index (BMI) from ECGs and test the hypothesis that discrepancies between NN-predicted BMI and measured BMI are indicative of underlying adiposity and/or concurrent cardiometabolic ill-health. Methods NN models were developed using 36,856 12-lead resting ECGs from the UK Biobank. Two architectures were developed for continuous and categorical BMI estimation (normal weight [BMI, Graphical abstract

The survival processing advantage refers to the finding that processing information according to its survival value improves memory retention. We used mass-testing across three experiments to examine whether the survival processing advantage could be extended to crime-related contexts when adopting both offender’s (Experiment 1 and 2) and victim’s (Experiment 3) perspectives. Interestingly, crime-related scenarios produced the lowest memory retention in Experiments 2 and 3, indicating no mnemonic benefit resulting from crimerelated processing. Furthermore, in Experiments 1 and 2, we failed to replicate the standard survival processing effect, while in Experiment 3 the superior survival memory retention emerged in comparison with the standard control conditions (i.e., moving and pleasantness). Overall, our experiments showed that crime-related contexts did not lead to superior memory retention. Moreover, although we detected some failures to replicate the survival processing effect, this evidence is not sufficiently compelling to argue that there was a general absence of the survival processing advantage.

INTRODUCTION Nowadays the majority of the surgical procedures are video surgeries. Despite technological advances, some problems remain. The buildup of residues in front of the lens is an example of this problem. To solve it, Abreu et al. (Surg Technol Int 26:43-47, 2015) developed LacrimaSurg, which works as a lacrimal duct in the optics preventing fogging and residues buildup on it. This had 98.1% of efficiency in an experimental study. OBJECTIVE Study feasibility and safety of the device under real surgical conditions. MATERIALS AND METHODS A pilot study included 30 patients undergoing thoracic procedures using LacrimaSurg. Procedures were recorded for further analysis by investigators. The characteristics of patients (age, sex, body mass index, Charlton comorbidity index), data of environment (Temperatures variances), and data of procedures (type of surgery and duration of it) were recorded. The investigators watched the videos and recorded the residue buildup and fogging events that impaired surgeon's vision. The number of times the optics got dirty, need for further jets of crystalloid solution, and need for mechanical cleaning were collected to evaluate efficacy. Comparative serum measurements of electrolytes before and after surgery were studied. Data were organized and analyzed by simple linear correlations and t test for continuous variables and Fisher's test for categorical variables. RESULTS The use of the device allowed 97% of the procedures to be performed without interruption. No characteristics inherent to the patients or to the procedures that lead to fogging or filth of the optics were identified. There were no statistically significant differences between pre- and postoperative serum ions, and no postoperative complications related to the use of the device were observed. CONCLUSION The device was effective in preventing interruption of surgical procedures due to dirt or fogging, its use was considered safe, and did not cause postoperative complications.

This paper presents the results of the analysis of acoustic emission signals (AE) recorded during the propagation of sound waves in rock samples. The sources are excited by breaking a 3-mm-thick pencil lead (Hsu-Nielsen) on the surface of the rock samples at different AE source locations. Ten repetitions of pencil lead fracturing were performed at a given location. A VS150-M piezoelectric sensor with a frequency range of 100–450 kHz was attached to the upper surface of the rock samples. The results showed that the AE energy and the average frequency of the acoustic emission signals in the rock samples decreased with increasing distance from the AE source locations. These results can be used to establish a relationship between the characteristics of the acoustic emission signals and different rock types at different AE source locations.

Smartphones that can support and assist the screening of various cardiovascular diseases are gaining popularity in recent years. The timely detection, diagnosis, and treatment of atrial fibrillation (AF) are critical, especially for those who are at risk of stroke. AF detection via screening with wearable devices should always be confirmed by a standard 12-lead electrocardiogram (ECG). However, the inability to perform on-site AF confirmatory testing results in increased patient anxiety, followed by unnecessary diagnostic procedures and treatments. Also, the delay in confirmation procedure may conclude the condition as non-AF while it was indeed present at the time of screening. To overcome these challenges, we propose an efficient on-site confirmatory testing for AF with 12-lead ECG derived from the reduced lead set (RLS) in a wireless body area network (WBAN) environment. The reduction in the number of leads enhances the comfort level of patients as well as minimizes the hurdles associated with continuous telemonitoring applications such as data transmission, storage, and bandwidth of the overall system. The proposed method is characterized by segment-wise regression and a lead selection algorithm, facilitating improved P-wave reconstruction. Further, an efficient AF detection algorithm is proposed by incorporating a novel three-level P-wave evidence score with an RR irregularity evidence score. The proposed on-site AF confirmation test reduces false positives and false negatives by 88% and 53% respectively, compared to single lead screening. In addition, the proposed lead derivation method improves accuracy, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$F_1$$\end{document}F1-score, and Matthews correlation coefficient (MCC) for the on-site AF detection compared to existing related methods.

The objective of this study was to determine the influence of VKORC1 and CYP2C9 polymorphisms on warfarin resistant patients. Warfarin resistance is described as the inability to prolong the prothrombin time or raise the INR up to the 2 therapeutic range when the drug is given at typically doses. Polymorphisms may play a role as some VKORC1 and CYP2C9 variant alleles are known to be associated with these circumstances. 28 patients who were taking warfarin more than 15 mg/day and had INR values below 2.1 and had thromboembolic events while using warfarin were enrolled in this study. Heterozygote mutation in the VKORC1 gene was identified in 15 of 28 patients. Seven patients had heterozygote mutation of the CYP2C9 gene, and that may correspond to the ultrarapid metabolism of warfarin. VKORC1 and CYP2C9 polymorphism contribute to the difference in dose requirement amongst the patients, but other additional possible factors may play a role in different races. We suggest that medicians may use this tests before starting warfarin therapy and shape the treatment course according to this results.

INTRODUCTION Inadvertent implantation from the subclavian/axillary arteries is uncommon and has been rarely reported. Complications are frequent, mainly driven by thromboembolic events. Lead extraction, depending on the dwell time may be challenging and associated with thromboembolic events Case Report: We report the case of an 87-year-old man who had involuntarily pacemaker lead implanted into the left ventricle through the left subclavian artery. An extraction procedure was performed with surgical dissection to the artery and simple traction of the probe without complication. CONCLUSION Percutaneous lead extraction using surgical dissection is a therapeutic option for less than one year old left ventricle inadvertent lead implantation.

Background: Adding wearable resistance (WR) to training results in superior performance compared with unloaded conditions. However, it is unclear if adding WR during warm-up influences training load (TL) in the subsequent session. The aim of this research was to track TL in soccer players during the transition from late preseason to early in-season and examine whether adding WR to the lower leg during a warm-up influenced TL measures during warm-ups and on-field training sessions after WR was removed. Hypothesis: The addition of WR worn on the lower legs during an on-field warm-up would lead to decreases in relatively high-intensity external TL metrics, such as distance covered >6.11 m∙s−1 and acceleration and deceleration >/−2 and increases in internal TL during the warm-up, yet would have little effect on the subsequent training session when WR was removed. Study Design: Matched-pair randomized design. Level of Evidence: Level 3. Methods: A total of 28 soccer players were allocated to either a WR training (WRT = 14) or unloaded (control [CON] = 14) group. Both groups performed the same warm-up and on-field training for 8 weeks, with the WRT group wearing 200 g to 600 g loads on their lower leg during the warm-up. External TL was measured via global positioning system data and internal TL was assessed using session rating of perceived exertion (sRPE × time per session). Results: No statistically significant between-group differences ( P ≥ 0.05) were identified for any TL measurement during either warm-ups or training sessions. Lower leg WR resulted in trivial to moderate effects for all external TL metrics (−16.9% to 2.40%; d = −0.61 to 0.14) and sRPE (−0.33%; d = −0.03) during the warm-up and trivial to small effects on all external TL metrics (−8.95% to −0.36%; d = −0.45 to −0.30) and sRPE (3.39%; d = 0.33) during training sessions. Conclusion: Warming up with lower leg WR negatively affects neither the quality and quantity of the warm-up nor the subsequent training session once WR is removed. Clinical Relevance: Using WR on the lower leg during on-field warm-ups may be a means to “microdose” strength training while not unduly increasing TL. However, further research is needed to determine the influence of WR on strength qualities.

Left bundle branch pacing (LBBP) is a novel near-physiological pacing method that still lacks quantitative criteria to guide the selection of lead-implanted sites to enhance the success likelihood of lead deployments. This study aimed to quantitatively analyze the relationships of LBBP success likelihood to the distribution of lead-implanted sites and the lead-localization-pacing electrocardiographic (ECG) features. All the lead-implanted sites in patients with finally successful LBBP were enrolled for analysis, including successful and failed sites. A novel coordinate system was invented to describe the sites’ distribution as longitudinal distance (longit-dist) and lateral distance (lat-dist). Corrected distance parameters were generated to eliminate the cardiac dimension variations. The lead-localization-pacing ECG parameters were also collected, such as paced QRS duration (locat-QRSd), left ventricular activation time (locat-LVAT), LVAT/QRSd ratio (locat-LVAT/QRSd), and QRS directions. A total of 94 patients with 105 successful sites and 93 failed sites were enrolled. Longit-dist and corrected longit-dist of successful sites were significantly longer, while locat-QRSd and locat-LVAT were shorter and locat-LVAT/QRSd was lower than failed sites. There was a positive dose–response relationship between LBBP success likelihood and corrected longit-dist with a cut-off of 26.95 mm, whereas there were negative dose–response relationships of LBBP success likelihood to locat-QRSd, locat-LVAT, and locat-LVAT/QRSd with the cut-offs of 142 ms, 92 ms, and 64.7%, respectively. Downward QRS direction in II/III ECG leads was also associated with successful LBBP. Longit-dist, locat-QRSd, locat-LVAT, and locat-LVAT/QRSd were quantitative parameters to guide the selection of lead-implanted sites during LBBP implantation. Quantitative distance and electrocardiographic parameters for lead-implanted site selection to enhance the success likelihood of left bundle branch pacing. LBBP, left bundle branch pacing; Longit-dist, longitudinal distance; CL-apex-dist, distance from contraction line to apex; LBBB, left bundle branch block; IVCD, intraventricular conduction delay; Locat-QRSd, lead-localization-pacing QRS duration; Locat-LVAT, lead-localization-pacing left ventricular activation time; Locat-LVAT/QRSd, lead-localization-pacing LVAT/QRSd ratio.

DESIGN The objective of this study was to establish whether autoinflation was an effective intervention in a paediatric audiology service. This was a pragmatic retrospective study with historical controls using a paired availability design. SETTING The study took place at a single paediatric audiology service in England. PARTICIPANTS All children seen in the clinic over a two-year period who were aged between 3 and 11 years and who had a type B tympanogram in at least one ear were included. The Otovent autoinflation device was available as a treatment option over the second year (Cohort B) but not the first (Cohort A). There were 976 children included in the study: Cohort A comprised 513 children, Cohort B comprised 463 children. MAIN OUTCOME MEASURES The aims were to evaluate whether there was improvement in hearing thresholds following introduction of an autoinflation device, and whether there was a reduction in further audiology follow-ups, and in referrals to an ear, nose and throat specialist for consideration of ventilation tube insertion. RESULTS AND CONCLUSIONS There was a statistically significant improvement in hearing thresholds in Cohort B compared to Cohort A, however the improvements were clinically minimal with small effect sizes. There was no significant difference in improvement of tympanometry results between the two cohorts. Significantly more children in Cohort B (autoinflation group) were referred to an ear, nose and throat specialist after their second appointment compared to Cohort A. It was feasible to introduce autoinflation into the care pathway, however there was no evidence of clinically meaningful improved outcomes for patients.

Mobile diamond wire sawing is a highly flexible, productive and, versatile cutting process. Accordingly, it is used in many areas, such as the dismantling of nuclear power plants or wind turbines. Despite the widespread use of the process, the cutting process requires continuous manual monitoring by the machine operator. This is due to the continuously changing cutting conditions. A common process error is tool breakage. It is often caused by the displacement of the grinding segments (cutting beads). Due to the cutting speed (up to 30 m/s), these failures cannot be detected and prevented by the machine operator. However, a measuring system or process monitoring does not exist yet. Accordingly, a damaged diamond wire can become hooked, which often results in wire breaks. As a result, grinding segments break away from the wire, which can lead to deadly accidents. Therefore, a new approach for monitoring the tool for diamond wire grinding will be investigated. The paper is divided into five sections. First, the requirements for the sensor system are derived. After the selection of a measuring principle and the functional verification in the grinding process, the monitoring approach is presented and features for monitoring the tool with regard to the displacement of grinding segments are described. It was shown that the developed approach is suitable for monitoring the diamond wire tool during the sawing process. The investigation on a prepared diamond wire tool also demonstrated that the feature allows the detection of displacing grinding segments already from 2 mm.

Aims To evaluate the benefit of speckle tracking radial strain imaging (STRSI)-guided left ventricular (LV) lead (LVL) positioning in cardiac resynchronization therapy (CRT) in patients (pts) with ischaemic cardiomyopathy with CRT indication. Methods and results We conducted a prospective randomized controlled trial. Patients were enrolled in nine centres with 2:1 randomization into two groups (guided vs. control). Patients underwent STRSI to identify the optimal LV position from six LV segments at midventricular level. Implantation via STRSI was attempted for recommended segment in the guided group only. Follow-up included echocardiography (6 months) and clinical evaluation (6 and 12 months). The primary endpoint was comparison % reduction in LV end-systolic volume at 6 months with baseline. Secondary endpoints included hospitalizations for heart failure and death, and improvement in additional echocardiographic measurements and quality of life score. A total of 172 patients (115 guided vs. 57 control) were enrolled. In the guided group, 60% of the implanted LV leads were adjudicated to be successfully located at the recommended segment, whereas in the control group 44% reached the best STRSI determined segment. There was no difference between the groups in any of the primary or secondary endpoints at 6 and 12 months. Conclusion Our findings suggest that echo-guided implantation of an LV lead using STRSI does not improve the clinical or echocardiographic response compared with conventional implantation.

Background Lead exposure is associated with behavioral problems in children, but the age(s) of greatest susceptibility to low-level lead exposure is unknown. Objective We evaluated the association of repeated blood lead concentrations with parent-reported behaviors to identify periods of heightened susceptibility during infancy and childhood (HOME Study; Cincinnati, OH; 2003-2006; n = 244). Methods We quantified lead in whole blood samples (ages 1, 2, 3, 4, 5, and 8 years) and assessed behavior using the Behavioral Assessment System for Children-2 (BASC-2; ages 2, 3, 4, 5, and 8 years). We used multiple informant models and modified Poisson regression to estimate covariate-adjusted associations of ln-transformed blood lead concentrations with continuous BASC-2 T-scores and the relative risk of behavior scores classified as at-risk or clinically significant, respectively. Results We observed trends indicating that higher blood lead concentrations at all ages were adversely associated with scores on behavioral scales. On the Externalizing Problems and Adaptive Skills scales, these associations were strongest for blood lead concentrations at age 8 years (β = 3.1-point; 95% CI = 0.7, 5.4 and β = -2.2-point; 95% CI = -4.9, 0.5, respectively) compared with other ages. Overall, higher blood lead concentrations were associated with elevated risk of behavior scores classified as at-risk or clinically significant on the Adaptive Skills, Behavioral Symptom Index, and Externalizing Problems scales. Significance Contemporary levels of lead exposure during the first 8 years of life were associated with ADHD-related behaviors, specifically aggression, hyperactivity, and conduct problems. Impact statement Our results highlight the importance of primary lead prevention across childhood.

Implantable cardiac devices are widely used devices that serve several purposes. Complications from devices are not uncommon and include localized or systemic infections, device-related endocarditis, and device malfunction leading to serious outcomes, including death. Another possible complication that has been reported in the literature is thrombus formation on the device leads. We present a rare case of large thrombi forming on the leads of an implantable cardioverter defibrillator leading to lead fracture and device malfunction. After the device alerted for malfunction, the patient underwent a transesophageal echocardiogram which demonstrated masses on the right atrium and ventricle. He subsequently had a right atrial exploration and lead extraction which revealed large thrombi on the leads which histologically were identified as sterile vegetations.

Surges of COVID-19 infections could lead to insufficient supply of mechanical ventilators, and rationing of needed care. Multiplexing mechanical ventilators (co-MV) to serve multiple patients is a potential temporary solution. However, if patients are ventilated in parallel ventilation, there is currently no means to match ventilation requirements or patients, with no guidelines to date for co-MV. This research uses patient-specific clinically validated respiratory mechanics models to propose a method for patient matching and mechanical ventilator settings for two-patient co-MV under pressure control mode. The proposed method can simulate and estimate the resultant tidal volume of different combinations of co-ventilated patients. With both patients fulfilling the specified constraint under similar ventilation settings, the actual mechanical ventilator settings for co-MV are determined. This method allows clinicians to analyze in silico co-MV before clinical implementation.

Background Artificial intelligence can assist in cardiac image interpretation. Here, we achieved a substantial reduction in time required to read a cardiovascular magnetic resonance (CMR) study to estimate left atrial volume without compromising accuracy or reliability. Rather than deploying a fully automatic black-box, we propose to incorporate the automated LA volumetry into a human-centric interactive image-analysis process. Methods and results Atri-U, an automated data analysis pipeline for long-axis cardiac cine images, computes the atrial volume by: (i) detecting the end-systolic frame, (ii) outlining the endocardial borders of the LA, (iii) localizing the mitral annular hinge points and constructing the longitudinal atrial diameters, equivalent to the usual workup done by clinicians. In every step human interaction is possible, such that the results provided by the algorithm can be accepted, corrected, or re-done from scratch. Atri-U was trained and evaluated retrospectively on a sample of 300 patients and then applied to a consecutive clinical sample of 150 patients with various heart conditions. The agreement of the indexed LA volume between Atri-U and two experts was similar to the inter-rater agreement between clinicians (average overestimation of 0.8 mL/m2 with upper and lower limits of agreement of − 7.5 and 5.8 mL/m2, respectively). An expert cardiologist blinded to the origin of the annotations rated the outputs produced by Atri-U as acceptable in 97% of cases for step (i), 94% for step (ii) and 95% for step (iii), which was slightly lower than the acceptance rate of the outputs produced by a human expert radiologist in the same cases (92%, 100% and 100%, respectively). The assistance of Atri-U lead to an expected reduction in reading time of 66%—from 105 to 34 s, in our in-house clinical setting. Conclusions Our proposal enables automated calculation of the maximum LA volume approaching human accuracy and precision. The optional user interaction is possible at each processing step. As such, the assisted process sped up the routine CMR workflow by providing accurate, precise, and validated measurement results.

Needleless connectors (NCs) for vascular access have limited needlestick injuries, but complications including occlusion, thrombosis, and infections have increased despite reduced needlestick injuries. These complications relate to the ability of an NC design to limit volume fluctuations that can lead to fluid reflux with potential for microbial contamination. Different NC designs requiring specific usage protocols and training, a lack of clarity in NC function relative to manufacturer-designated categories, and confounding results from a limited number of studies comparing different NCs have resulted in confusion, ultimately leading to complications from undesirable fluid movement within the vascular access. The authors therefore quantified the magnitude of reflux with current commercially available NCs using a venous stimulator. Thirteen blinded NC designs spanning the categories of negative and positive displacement, neutral, and antireflux were tested to quantify fluid movement upon disconnection and reconnection from a representative intravenous pressure (3 NCs per design; 10 trials per NC). Trials for each NC tested followed consistent displacement trends leading to tight error bars. Blinded NCs were then characterized according to their function and compared with their category designation after unblinding. All positive and negative NCs functioned in a manner consistent with their respective category designations. Conversely, all NCs categorized as neutral actually functioned with negative displacement (ie, reflux upon disconnection; 4/5 NCs) or positive displacement (1/5 NCs). Only NCs classified as antireflux functioned as neutral, which was confirmed in a blinded bidirectional flow test. These results suggest that the neutral NC-marketed category may be confusing to users unless the particular NC design has an integrated antireflux component.

Background Despite the success of reverse shoulder arthroplasty (RSA), complication rates remain high (13% to 25%), due to instability, infection, and glenoid component loosening, which can lead to revision. The aim of the present study was to report the early clinical outcomes of RSA using a new hybrid baseplate design, in comparison with the literature on other common RSA baseplates. Methods The authors retrospectively analyzed the records of 142 patients (142 shoulders) who underwent primary RSA using a hybrid baseplate design by the senior surgeons between May 2014 and December 2018. Preoperative and postoperative assessments included the Constant score (CS) and range of motion, including active forward elevation, external rotation, and internal rotation. Results Of the initial cohort of 142 patients, 13 were lost to follow-up (8.6%), 2 died (1.3%), and 8 required reoperations with implant removal (5.3%). The remaining 119 patients comprised 71 women (60%) and 48 men (40%), aged 73.6 ± 7.3 years at index surgery, 43 of whom required bony increased offset (36%). At a minimum follow-up of 2 years, the CS improved by 37.3 ± 16.1, active forward elevation increased by 51.2° ± 38.1°, external rotation increased by 16.4° ± 25.0°, and internal rotation increased by 1.5 ± 3.2. Conclusion At a minimum follow-up of 2 years after RSA using a new hybrid baseplate system, the CS and range of motion were satisfactory and comparable to those in recent systematic reviews. The findings of this study suggest that this hybrid baseplate system provides satisfactory outcomes in the short term, although longer follow-up studies are needed to validate its long-term efficacy.

The mainstay of treatment for obstructive sleep apnea is positive airway pressure therapy, which may be difficult for some patients to tolerate leading to compromised adherence and requiring alternative therapies. Hypoglossal nerve stimulation has become an option for those who meet implantation criteria. Implantation of the device is an ambulatory surgical procedure and is generally well-tolerated, though rare adverse events have been reported. We report an unusual complication of hypoglossal nerve stimulation in a patient who had initial success with this therapy. After 3 years of treatment, the sensor lead penetrated into the pleural space. Components of the hypoglossal nerve stimulation were explanted, and a new sensor lead and generator were reimplanted. The new device was activated, and therapy was successfully resumed. This case demonstrates that there is a potential for a delayed complication of sensor lead penetration into the pleural space, which has only rarely been reported. CITATION: Lou B, Hahn S, Korotun M, Quintero L, Shikowitz M, Greenberg H. Space invader: pleural penetration of a hypoglossal nerve stimulator sensor lead. J Clin Sleep Med. 2021;17(11):2329–2332.

Background Not every lead contributes equally in the interpretation of an ECG. There are some abnormalities in which the lead importance is not clear either from cardiac electrophysiology or experience. Therefore, it is beneficial to develop an algorithm to quantify the lead importance in the reading of ECGs, namely to determine how much to weigh the evidence from each individual lead when interpreting ECG. Methods One representative beat per ECG lead was constructed for each ECG in a database. An algorithm was developed to find the top K (K = 1, 5, 10, 20, 50, 100) ECGs in the database that had the most similar morphology to the query ECG, independently for each lead. For each lead, the query ECG was interpreted based on the weighted average voting on the most similar ECGs by applying a variety of thresholds. For each category of abnormality, we found the threshold that maximized the median F1 score of sensitivity and positive predictive value among all ECG leads. Finally, the F1 score of each lead at this chosen threshold was defined as the importance value for that lead. Results Eighteen morphology-based categories of abnormality were investigated for two databases. For most, the lead importance confirmed what expert ECG readers already know. However, it also revealed new insights. For example, lead aVR appeared in the top 6 most important leads in 11 and 12 categories of abnormality in two databases respectively, and ranked first among 12 leads if summarizing all categories. Conclusions Lead importance information may be useful in selecting only the most important leads to screen for a specific abnormality, for example using wearable patches.

This study investigated the effects of silver powder modification on intermetallic compound (IMC) formation and silver leaching during soldering at high temperatures. Silica nanoparticles (NPs) were deposited onto a silver powder surface to inhibit silver leaching, which can lead to soldering joint failure during high-temperature soldering. The NPs were deposited through hydrolysis and a condensation reaction of tetraethyl orthosilicate (TEOS) based on the Stöber method. Fourier transform infrared spectroscopy and scanning electron microscopy were used to observe the microstructures of silver powders after the deposition of silica NPs with various TEOS concentrations and various deposition times. As the deposition time increased, the amount of silica NPs on the surface of the silver powder increased. The transmission electron microscopy results show that silica NPs were located at the IMC grain boundaries, which can hinder the dissolution of IMCs by lead-free solder melt along grain boundaries during soldering, retarding silver leaching. The growth kinetics and mechanism of IMCs during soldering were investigated. The results show that the growth of IMCs is mainly dominated by bulk diffusion. The activation energy for IMC growth increased and the growth rate decreased with increasing silica NP addition and deposition time.

Summary Tin-lead perovskite solar cells (Sn-Pb PSCs) with low band gap (1.2–1.4 eV) are expected to achieve the maximum-power conversion efficiency (PCE) of single-junction devices given by the Shockley-Queisser limit. However, over 40 mol % Pb2+ is necessary to suppress the oxidation of Sn2+, which causes serious p-type self-doping. Here, we propose a new galvanic displacement reaction (GDR) method, through using lead powder as lead source and reductant simultaneously to resolve the above-mentioned issue. Lead powder could fully reduce Sn4+, but not Sn2+, in precursor, meanwhile suppressing the formation of iodide in film. Finally, Sn-Pb PSCs with low lead content and highest efficiency for MA-free-based devices (PCE: 18.34% for 8.5 mol % Pb2+, 20.01% for 18.7 mol % Pb2+) were realized. The unencapsulated devices retained unchanged or 81% of the original efficiency after storing for 2,352 h or tracking at maximum-power point (MPP) for 700 h in N2 atmosphere (O2 ≤ 50 ppm).

OBJECTIVE Surgical correction of synostotic cranial sutures is typically performed early in an affected child’s life. Depending on the severity of the cranial synostoses, different aspects of the surgical treatment may have varying degrees of importance. In this sense, the aesthetic appearance in children with normal neurological development in single-suture synostosis plays an important role in self-perception and social acceptance for both the patients themselves and their caregivers. Therefore, in this study, the authors aimed to evaluate the aesthetic outcome after surgical correction in a cohort of patients with nonsyndromic sagittal suture synostosis. METHODS Between December 2002 and December 2019, a total of 99 patients underwent surgical correction of a synostotic sagittal suture at the Medical University of Vienna. Depending on their age, patients underwent either an extended midline strip craniectomy (EMSC) (< 4 months) or a modified pi procedure (MPP) (≥ 4 months). After the surgical procedure, the outcome was evaluated by the treating neurosurgeon at 1- and 12-month follow-up visits, and after approximately 5 years, before the patient entered elementary school. In addition to that, the patients’ caregivers were asked to evaluate the aesthetic outcome of the surgical procedure after 12 months. These results were then compared to evaluate potential differences in the perception of the surgical outcome. RESULTS After 12 months, the majority of the included patients were evaluated as having a good aesthetic outcome by the treating neurosurgeon (97%) and by their caregivers (89%). These differences did not show statistical significance (p = 0.11). Similarly, no differences in the aesthetic outcome depending on the surgical procedure performed could be found (p = 0.55). At the last follow-up visit, before entering elementary school, all available patients had an excellent or good surgical outcome. Moreover, the majority of caregivers (73%) reported that their child had a normal head shape appearance after surgical correction. CONCLUSIONS The results of this study have suggested that surgical correction of sagittal suture synostosis by simple operative techniques leads to a good aesthetic outcome and a normal head shape appearance in the majority of patients. An analysis of the evaluation of the surgical outcome by either the treating neurosurgeon or the patient caregivers showed comparable results and, thus, early intervention with simple surgical techniques can be recommended.

Introduction Implantation of a reverse shoulder arthroplasty (RSA) impacts deltoid length, shape and tension. Quantification of changes in deltoid muscle tension with implantation of RSA has remained elusive. The purpose of this study was to use shear wave elastography (SWE) to quantify deltoid muscle stiffness preoperatively, intraoperatively and postoperatively in patients undergoing RSA. Methods Twenty patients scheduled to undergo RSA (ReUnion, Stryker) were prospectively enrolled in this study. A single observer trained in SWE quantified deltoid stiffness preoperatively, intraoperatively, and postoperatively. Clinical evaluation included pain, motion, quickDASH, ASES, Oxford, and subjective shoulder value scores. Preoperative and postoperative radiographs were measured by an independent observer to determine the lateralization and distalization shoulder angles (LSA and DSA). A statistical analysis was then performed to determine whether changes in deltoid muscle stiffness correlated with any of these parameters. Results Implantation of a RSA lead to an increase SWE deltoid stiffness value from 22.4 ± 4.2 kPa preoperatively to 29.9 ± 5.23 kPa (P˂ .0001) immediately after surgery, and 26.6 ± 6.6kPa (P= .03) at most recent follow-up. Preoperative SWE deltoid stiffness values did not differ when measured in the office or under anesthesia. Reverse arthroplasty did not significantly change the LSA (P= .051), but did increase the DSA (P Conclusion After implantation of one RSA design incorporating glenoid and humeral lateralization, deltoid stiffness as measured with SWE increased significantly. Deltoid stiffness seems to correlate with joint distalization, elevation and external rotation. SWE seems to be reliable to quantify deltoid stiffness after reverse shoulder arthroplasty. Level of Evidence Level IV; Diagnostic Study

The paper illustrates the performance of Tri-Gate (TG) Dual Material (DM) SOI (Silicon on Insulator) Junctionless (JL) FET operating in Junction Accumulation Mode (JAM). An analytical model is developed to evaluate its performance. The device is also simulated using Silvaco device simulator. Both the analytical and simulation results are compared and found to match closely. Quasi 3-D modeling approach is adopted here to determine the surface potential of the above device. In this technique, the entire 3-D device is segregated into two 2-D devices with certain physical constraints. These 2-D devices are then analyzed separately to obtain the surface potentials, which are added together using suitable multiplication factors to get the surface potential of the 3-D device. This surface potential is, in turn, used to model the threshold voltage, sub-threshold drain current ( I d,sub ) and the drain induced barrier lowering (DIBL). The proposed device configuration reduces the I OFF significantly and offers excellent immunity to SCEs. The response of the proposed device is studied for the variations of certain device parameters, such as, thickness of High- K dielectric layer in stack gate, channel doping, and the workfunctions as well as lengths of the gate metals. Such study will lead to turn the proposed device immune to short channel effects through proper choice of various parameters.

In this paper, the first demonstration of direct ultratrace determination of lead in a single human hair by direct current-atmospheric pressure glow discharge-atomic emission spectrometry (DC-APGD-AES) coupled with electromagnetic heating vaporization (EMV) was described. Only the ultramicro mass of a human hair sample (about 0.15 mg, often a single human hair) was required during the analysis, and fast detection was implemented without tedious pretreatment processes, such as grinding and digestion. A limit of detection (LOD) of 30.8 μg kg-1 (4.8 pg) for Pb was obtained under optimized conditions, which was even equivalent to that of conventional LA-ICP-MS/ETV-ICP-MS/GFAAS. EMV-APGD-AES, meanwhile, can facilitate miniaturization and portability with low power and small size. The accuracy and practicality of the method were verified by the analysis of certified reference materials (CRMs) GBW09101b (human hair) and human hair samples from three volunteers. A simple, efficient, and low-cost method for detecting Pb in human hair has been developed.

INTRODUCTION His bundle pacing (HBP) and left bundle branch area pacing (LBBAP) have emerged as attractive alternatives to traditional biventricular pacing to achieve cardiac resynchronization therapy. Early reported results have been inconsistent, particularly amongst patients in whom initial placement with traditional approaches has been unsuccessful or those with complex anatomy or congenital abnormalities. In this report, we describe the use of three-dimensional electroanatomic mapping (EAM) in five selected cases. METHODS Five patients from multiple clinical sites underwent EAM-guided HBP or LBBAP by highly trained electrophysiologists with significant experience with conduction system pacing. Each patient in this series underwent EAM-guided conduction system pacing due to complex anatomy and/or prior failed lead implantation. RESULTS EAM-guided lead implantation was successful in all five cases. Capture thresholds were relatively low and patients continued to have evidence of successful lead implantation with minimum 1-month follow-up. The fluoroscopy time varied, likely owing to the variable complexity of the cases. CONCLUSIONS The use of EAM, in combination with traditional intracardiac electrograms with or without fluoroscopy, allows more targeted and precise placement of leads for HBP and LBBAP pacing. Further investigation is needed to determine this strategy's long-term performance and to optimize patient selection.

To assess whether different methods for communicating the probability of treatment complications for operative and nonoperative appendicitis treatments result in differences in risk perception.Surgeons must communicate the probability of treatment complications to patients, and how risks are communicated may impact the accuracy and variability in patient risk perceptions and ultimately their decision making.A series of online surveys of American adults communicated the probability of complications associated with surgical or antibiotic treatment of acute appendicitis. Probability was communicated with verbal descriptors (eg, "uncommon"), point estimates (eg, "3% risk"), or risk ranges (eg, "1% to 5%"). Respondents then estimated the probability of a complication for a "typical patient with appendicitis." The Fligner-Killeen test of homogeneity of variance was used to compare the variability in respondent risk estimates based on the method of probability communication.Among 296 respondents, variance in probability estimates was significantly higher when verbal descriptions were used compared to point estimates (P0.001) or risk ranges (P0.001). Identical verbal descriptors produced meaningfully different risk estimates depending on the complication being described. For example, "common" was perceived as a 45.6% for surgical site infection but 61.7% for antibiotic-associated diarrhea.Verbal probability descriptors are associated with widely varying and inaccurate perceptions about treatment risks. Surgeons should consider alternative ways to communicate probability during informed consent and shared decision-making discussions.

PURPOSE An MR thermometry (MRT) method with motion and field fluctuation compensation is proposed to measure non-invasively sub-degree brain temperature variations occurring through radiofrequency (RF) power deposition during MR exams. METHODS MRT at 7T with a multi-slice echo planar imaging (EPI) sequence and concurrent field monitoring was first tested in vitro to assess accuracy in the presence of external field perturbations, an optical probe being used for ground truth. In vivo, this strategy was complemented by a motion compensation scheme based on a dictionary pre-scan, as reported in some previous work, and was adapted to the human brain. Precision reached with this scheme was assessed on eight volunteers with a 5 minute-long low specific absorption rate (SAR) scan. Finally, temperature rise in the brain was measured twice on the same volunteers and with the same strategy, this time by employing a 20-minutes scan at the maximum SAR delivered with a commercial volume head coil. RESULTS In vitro, the root mean square (RMS) error between optical probe and MRT measurements was 0.02°C with field sensor correction. In vivo, the low SAR scan returned a precision in temperature change measurement with field monitoring and motion compensation of 0.05°C. The 20-minutes maximum SAR scan returned a temperature rise throughout the inner-brain in the range of 0-0.2°C. Brain periphery remained too sensitive with respect to motion to lead to equally conclusive results. CONCLUSION Sub-degree temperature rise in the inner human brain was characterized experimentally throughout RF exposure. Potential applications include improvement of human thermal models and revision of safety margins.

Aims Pre-excitation syndrome can lead to recurrent supraventricular tachycardias (SVTs) and carries a risk of sudden cardiac death (SCD). However, an underestimated consequence of antegrade conduction through an accessory pathway is fusion of intrinsic and accessory conduction that causes asynchronous activation and myocardial contraction that could be a cause for cardiac dysfunction and dilation. It is not known to what extent pre-excitation affects myocardial and physical performance in those patients. The aim of the study was to assess to what degree ventricular pre-excitation affects physical performance in children, using cardio-pulmonary exercise testing (CPET). Methods and results The study group consisted of 30 asymptomatic children, aged 8–17 years, with pre-excitation and no history or documentation of SVT compared to 31 healthy controls matched according to sex and age. All patients underwent routine cardiology assessment and then CPET. Echocardiography showed there were no differences in the left ventricular size and function between the study and control group. During the CPET both, patients and controls achieved maximal effort. Patients in the study group showed significantly lower values of VO2max and anaerobic threshold when compared to controls. The most affected subgroup was patients with persistent pre-excitation throughout the exercise. Conclusions Physical performance is affected in children with pre-excitation. This effect is stronger in patients with persistent delta wave observed throughout the exercise.

Osteoporosis is the leading cause of deformity and bones fracture all over the world and has some relationship with the blood concentrations of calcium and lead. Therefore, in the current study, the blood samples of 58 control and 56 clinically diagnosed osteoporotic and osteopenic patients were taken from different hospitals in Pakistan and analyzed for calcium and lead concentrations using atomic absorption spectrometry. In female control samples, the mean calcium value was found to be 98.53 ± 4.81 μg/mL, and in male control samples, the mean blood calcium level was found to be 121.33 ± 7.27 μg/mL. In female control samples, the mean lead value was found to be 0.133 ± 0.005 μg/mL, and in male control samples, the mean lead level was found to be 0.183 ± 0.008 μg/mL. All the male and female control samples showed a mean value of calcium of 115.63 ± 5.2 μg/mL and a mean value of lead of 0.153 ± 0.007 μg/mL. In osteoporotic female patients, the decline in the mean calcium value was found to be 34.93 ± 1.9 μg/mL, and in male patients, the decrease in the mean calcium level was found to be 47.73 ± 2.5 μg/mL. The increase in the mean value of lead in osteoporotic females was 4.13 ± 0.22 μg/mL, whereas in male patients, the increase in the mean lead value was 0.95 ± 0.07 μg/mL. All the male and female patients showed a decrease in the mean value of calcium of 41.43 ± 2.2 μg/mL and an increase in the mean value of Pb of 3.63 ± 0.16 μg/mL.

Total knee arthroplasty (TKA) is one of the most commonly performed, major elective surgeries in the USA. African American TKA patients on average experience worse clinical outcomes than whites, including lower improvements in patient-reported outcomes and higher rates of complications, hospital readmissions, and reoperations. The mechanisms leading to these racial health disparities are unclear, but likely involve patient, provider, healthcare system, and societal factors. Lower physical and mental health at baseline, lower social support, provider bias, lower rates of health insurance coverage, higher utilization of lower quality hospitals, and systemic racism may contribute to the inferior outcomes that African Americans experience. Limited evidence suggests that improving the quality of surgical care can offset these factors and lead to a reduction in outcome disparities.

Background Few studies have assessed the impact of overlapping surgery during different timepoints of neurosurgical procedures. Objective To evaluate the impact of overlap before the critical portion of surgery on short-term patient outcomes following lumbar fusion. Methods In total, 3799 consecutive patients who underwent single-level, posterior-only lumbar fusion over 6 yr (2013-2019) at an academic hospital system were retrospectively studied. Outcomes included 30-d emergency department (ED) visit, readmission, reoperation, mortality, overall morbidity, and overall morbidity/surgical complications. Duration of overlap that occurred before the critical portion of surgery was calculated as a percentage of total beginning operative time. Univariate logistic regression was used to assess the impact of incremental 1% increases in the duration of overlap within the whole population and patients with beginning overlap. Subsequently, univariate analysis was used to compare exact matched patients with the least (bottom 40%) and most amounts of overlap (100% beginning overlap). Coarsened exact matching was used to match patients on key demographic factors, as well as attending surgeon. Significance was set at a P-value Results Increased duration of beginning overlap was associated with a decrease in 30-d ED visit (P = .03) within all patients with beginning overlap, but not within the whole population undergoing lumbar fusion. Duration of beginning overlap was not associated with any other short-term morbidity or mortality outcome in either the whole population or patients with beginning overlap. Conclusion Increased duration of overlap before the critical step of surgery does not predict adverse short-term outcomes after single-level, posterior-only lumbar fusion.

Background: Reactive oxygen species (ROS) might increase growth and adhesion of endometrial cells in the peritoneal cavity, and lead to endometriosis. In this study the we evaluate the effect of an antioxidant, acetylsalicylic acid (aspirin), to determine whether aspirin administration to patients with endometriosis would affect pelvic pain and disease recurrence. Material and methods: This randomized controlled trial was conducted from March 2018 to March 2020 on women, 19 to 40 years of age, who were diagnosed with endometriosis after undergoing laparoscopic surgery. Study participants were randomly assigned to one of two groups, Oral contraceptive pills (OCP) and placebo or OCP and aspirin, which were administered daily for 6 months. Pelvic pain, dysmenorrhea, mass size, and menstrual bleeding were evaluated at 3 and 6 months. Results: There were 38 patients in the aspirin group and 49 participants in the placebo group. The mean dysmenorrhea Visual analog scale (VAS) score after 3 months was 2.24 in the aspirin group and 3.61 in the placebo group. After 6 months, the dysmenorrhea VAS scores were 0.68 (aspirin group) and 2.69 (placebo group) ( p = 0.005 and p = 0.00, respectively). Dyspareunia and pelvic pain showed significant reductions ( p = 0.00). Six patients in the control group and four patients in the aspirin group experienced lesion recurrence ( p = 0.45). Conclusion: The results suggest that aspirin, as an antioxidant, could effectively reduce pain in women with endometriosis. However, additional studies that enroll larger numbers of participants and long-term follow up will enable better evaluation of recurrence.

Résumé: Contexte: La mise en place de la sonde ventriculaire gauche dans une zone exempte de cicatrice myocardique est un facteur déterminant de la réponse au traitement de resynchronisation cardiaque. Nous avons cherché à développer et à valider une approche électrocardiographique (ECG) simple, concrète et novatrice afin de repérer de manière peropératoire la présence de tissu cicatriciel au ventricule gauche (VG). Nous avons émis l'hypothèse qu'il y aurait une diminution de l'amplitude du rythme de stimulation du ventricule gauche mesurée à la surface de la peau à l'ECG haute résolution (HR) lors de la stimulation de régions du VG présentant du tissu cicatriciel comparativement aux régions exemptes de cicatrices. Il s'agit de ce que nous appelons la méthode EASE (ECG Amplitude Signal Evaluation). Méthodologie: Des patients vus de manière consécutive qui présentaient une dysfonction systolique ischémique du VG et répondaient aux critères standard pour l'implantation de novo d'un dispositif de resynchronisation cardiaque ont été recrutés de manière prospective. Tous ont fait l'objet d'une résonance magnétique cardiaque améliorée par injection d'un produit de contraste avant l'implantation pour évaluer la présence de tissu cicatriciel. L'amplitude moyenne de l'impulsion de stimulation du VG a été échantillonnée sur l'ECG de surface HR réalisé pendant l'intervention, puis comparée aux résultats de la résonance magnétique cardiaque. Résultats: En tout, 38 points de stimulation du VG ont été évalués chez 13 receveurs. Le voltage médian mesuré sur l'ECG de surface HR dans les régions présentant du tissu cicatriciel était réduit de 41 % (intervalle interquartile : 17 % à 63 %), tandis qu'il n'y avait pas de changement mesurable du voltage (intervalle interquartile : 0 à 0 %) dans les régions exemptes de cicatrices par rapport à l'amplitude maximale (test de Wilcoxon, p < 0,0001). Conclusion: La méthode EASE semble avoir une utilité potentielle en tant que nouvel outil peropératoire pour guider la mise en place de la sonde ventriculaire gauche dans les régions exemptes de cicatrices. Il faudra réaliser d'autres travaux pour valider l'utilité de cette méthode dans une cohorte de patients plus importante. Abstract: Background: The placement of the left ventricular (LV) lead in an area free of myocardial scar is an important determinant of cardiac resynchronization therapy response. We sought to develop and validate a simple, practical, and novel electrocardiographic (ECG)-based approach to intraoperatively identify the presence of LV scar. We hypothesized that there would be a reduction in the measured amplitude of the LV pacing stimulus on the skin surface using a high-resolution (HR) ECG when pacing from LV regions with scar compared with regions without scar. We term this the ECG Amplitude Signal Evaluation (EASE) method. Methods: Consecutive patients with ischemic LV systolic dysfunction and standard criteria for de novo cardiac resynchronization therapy implantation were prospectively enrolled. All underwent a preimplant contrast-enhanced cardiac magnetic resonance study to assess for scar. The average amplitude of the LV pacing impulse was sampled on HR surface ECG intraprocedurally and then compared with the cardiac magnetic resonance results. Results: A total of 38 LV pacing sites were assessed among 13 recipients. The median voltage measured on the surface HR ECG in regions with scar was reduced by 41% (interquartile range, 17% to 63%), whereas there was no measurable change in voltage (interquartile range, 0 to 0%) in regions without scar compared with the maximal amplitude (Wilcoxon P < 0.0001). Conclusion: The EASE method appears to be of potential value as a novel intraoperative tool to guide LV lead placement to regions free of scar. Future work is required to validate the utility of this method in a larger patient cohort.

This study compared the NOx emissions of a nonroad compression ignition engine using pilot injection and a NH3-SCR system and revealed their effects on NOx reduction. Furthermore, the interaction of pilot injection and the NH3-SCR system on NOx reduction was also studied by simultaneously using the two technologies under broad engine operating conditions. The pilot-main interval and the rate of pilot-to-main injection used in this study are in the range of 2∼8 CA and 9.5∼58.5%, respectively. Results showed that alteration in the pilot-main injection interval and the pilot-injection fuel amount under low load conditions was prone to lead to more variation in NOx emissions in comparison with that under high-load conditions. Relative to the pilot-main injection interval, the pilot-injection fuel amount played a more important role in the NOx emission. Lower NOx emissions could be achieved when using a smaller pilot-injection amount. However, excessively advanced pilot injection and a larger pilot-injection amount would increase the NOx emissions. Under a lower engine load, the effect of pilot injection on NOx reduction enhanced, whereas the effect of the NH3-SCR system diminished. Over broad operating conditions, the NOx reduction percentage by pilot injection coupled with the SCR system was lower than the total reduction degree when separately using pilot injection and the SCR system.

Graphical abstract, Highlights • Tricuspid valve stenosis following pacemaker implantation is rare. • Advanced echocardiography can identify the cause. • Invasive hemodynamic evaluation can quantify the effects. • A multidisciplinary approach ensures an optimal treatment strategy.

Introduction Loading of dental implants has been performed in different protocols to achieve a high success rate and to decrease oral handicap timing. Many factors can contribute to the proper selection of loading protocol. Objectives This study evaluated the effect of early and immediate gradual loading protocols on the secondary stability of dental implants, which was measured by resonance frequency analysis. Material and Methods Ten patients each received two implants in the posterior maxillary region. At one side implants were loaded by progressive gradual loading using healing caps while the other side implants were loaded by early loading protocol. The secondary stability of dental implants measured using resonance frequency analysis afters 6 weeks from implantation day. Results There was no statistically significant difference between (Progressive loading protocol) and (early loading protocol) groups where (p=0.863). The highest mean value was found in (Progressive loading protocol) (77.86 ± 15.74), while the lowest mean value was found in (early loading protocol) (76.29 ± 17.63). Conclusion Trans mucosal healing is possible in the posterior maxilla with a very high success rate, especially if the implant was inserted with high primary stability. However, strict oral hygiene measure is mandatory to avoid plaque accumulation which may lead to mucositis. Progressive loading with a healing cap is not of a great benefit to the patients in terms of bone training, and it might cause pain while replacing healing caps.

Health problems with cardiovascular system disorders are still ranked high, according to data from the WHO reported that there are about 31% of causes of death globally are cardiovascular diseases. The purpose of this study was to develop a 12 lead electrocardiograph with 2 displays and the HC-05 as a real-time transmitter of heart signal data. The electrocardiogram signal is obtained from the wiretapping by attaching the electrode cable to the Lead I, Lead II, Lead III, aVR, aVL, and aVF leads, then processed on IC AD620, HPF and LPF filters and non-inverting amplifiers and then processed using Arduino UNO for further display. in the form of a signal on the Delphi 7 application. The research method is to measure the heart signal on the ECG Simulator, by testing several BPMs, namely 30, 60, 120 and 240 on each lead. After testing the signal equation at the 0.5mV setting by calculating the error rate, the highest error value is obtained in lead I, lead aVL and aVF of 7.14% and the smallest error is 3.57% error in lead III. Then at the 1mV setting by calculating the error rate, the highest error value in lead aVL is 7.14% and the smallest error is 2.36%. at the 2mV setting by calculating the error rate, the highest error value is obtained in leads aVL and aVF of 5.71% and the smallest error is obtained by an error of 2.1% in lead II. the results of this study are implemented so that in the future an ECG examination can be carried out and then monitored remotely like a doctor's room because the data communication uses bluetooth.

SUMMARY OBJECTIVE: Use Lead-DBS software to analyze stereotactical surgical outcome of an operated population and demonstrate that small target deviations do not compromise the stimulation of desired structures, even with small amperages. METHODS: Image exams of patients submitted to deep brain stimulation for movement disorders treatment were processed in Lead-DBS software. Electrode stereotactic coordinates were subtracted from the planned target and those deviations, compared among different anatomical targets and sides operated firstly and secondly. We also quantified the frequency of relation between the activated tissue volume and the planned target through computer simulations. RESULTS: None of the 16 electrodes were exactly implanted at the planned coordinates. A stimulation of 3 mA reached 62.5% of the times the planned coordinates, rising to 68.75% with a 3,5 mA. No statistical significance was demonstrated in any comparison of laterality and anatomical sites. CONCLUSIONS: The simulation of small amperage fields could reach the intended target even when electrode placement is suboptimal. Furthermore, such a goal can be achieved without overlapping the volume of activated tissue with undesired structures. Software Lead-DBS proved to be a valuable complementary asset for surgical stereotactical result assessment.

Background Right ventricular (RV) mid‐septal pacing has been proposed as an alternative to RV apical pacing. Fluoroscopic and electrocardiogram criteria are unreliable for predicting the RV mid‐septal lead position. This study aimed to define the optimal RV mid‐septal pacing site using RV angiography. Methods We randomized patients undergoing pacemaker implantation (PPM) to the RV angiography‐guided group (Group A) or conventional fluoroscopy‐guided group (Group F). In Group A, we performed an angiogram in right anterior oblique (RAO 30°), left anterior oblique (LAO 40°), and left lateral (LL) views. We made a 5‐segment grid in RAO 30° and LL views and a 3‐segment grid in LAO 40° on the angiographic silhouette to define the lead position. Computed tomography (CT) was used to validate the lead tip position in both groups. Results We enrolled 53 patients (Group A: 26, Group F: 27) with a mean age of 55.9 ± 12.2 years. CT images validated the lead position in the mid‐septum (Group A, 23 [88.5%]; Group F, 11 [40.7%], P = .0003) and anteroseptal (Group A, 3 [11.5%]; Group F, 5 [18.5%], P = .24). In Group F, the lead was in the anterior wall in 9 patients (33.3%) and the right ventricular outflow tract in 2 (7.4%) patients and none in these two positions in Group A. The lead tip in segment one on the angiographic 5‐segment grid in RAO 30° and LL views indicated a mid‐septal lead position on CT. Conclusions RV angiography is safe and may be used to confirm the mid‐septal lead position during PPM., The appropriate site for mid‐septal pacing is not defined. This study aimed to identify the site of mid‐septal implantation as guided by right ventricular angiography and was validated by computed tomography.