5,770 results on '"Le, Wang"'
Search Results
52. Optimization-improved thermal-mechanical simulation of welding residual stresses in welded connections.
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Le Wang and Xudong Qian
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- 2024
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53. Throughput Maximization for Covert UAV Relaying System.
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Haichao Wang 0001, Hengzhi Bai, Fei Li, Jin Chen 0007, and Le Wang 0004
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- 2024
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54. Adversarial Attack and Defense in Deep Ranking.
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Mo Zhou, Le Wang 0003, Zhenxing Niu, Qilin Zhang, Nanning Zheng 0001, and Gang Hua 0001
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- 2024
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55. Manufacturer encroachment and quality investment decisions in a two-period supply chain.
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Le Wang, Zhen He, Shuguang He 0001, and Yiwen Zhang 0005
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- 2024
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56. Inverse Adversarial Diversity Learning for Network Ensemble.
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Sanping Zhou, Jinjun Wang, Le Wang 0003, Xingyu Wan, Siqi Hui, and Nanning Zheng 0001
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- 2024
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57. Study on the green extraction of corncob xylan by deep eutectic solvent
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Bingyu Jiao, Le Wang, Haitao Gui, Zifu Ni, Rong Du, and Yuansen Hu
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Corncob ,Deep eutectic solvent ,Xylan ,Process optimization ,Extraction ,Agriculture ,Food processing and manufacture ,TP368-456 - Abstract
Corn as one of the world's major food crops, its by-product corn cob is also rich in resources. However, the unreasonable utilization of corn cob often causes the environmental pollution, waste of resources and other problems. As one of the most abundant polymers in nature, xylan is widely used in food, medicine, materials and other fields. Corn cob is rich in xylan, which is an ideal raw material for extracting xylan. However, the intractable lignin is covalently linked to xylan, which increases the difficulty of xylan extraction. It has been reported that the deep eutectic solvent (DES) could preferentially dissolve lignin in biomass, thereby dissolving the xylan. Then, the xylan in the extract was separated by ethanol precipitation method. The xylan precipitate was obtained after centrifugation, while the supernatant was retained. The components of the supernatant after ethanol precipitation were separated by the rotary evaporator. The ethanol, water and DES were collected for the subsequent extraction of corn cob xylan. In this study, a novel way was provided for the green production of corn cob xylan. The DES was used to extract xylan from corn cob which was used as the raw material. The effects of solid-liquid ratio, reaction time, reaction temperature and water content of DES on the extraction rate of corn cob xylan were investigated by the single factor test. Furthermore, the orthogonal test was designed to optimize the xylan extraction process. The structure of corn cob xylan was analyzed and verified. The results showed that the optimum extraction conditions of corn cob xylan were as follows: the ratio of corn cob to DES was 1 : 15 (g : mL), the extraction time was 3 h, the extraction temperature was 60 °C, and the water content of DES was 70%. Under these conditions, the extraction rate of xylan was 16.46%. The extracted corn cob xylan was distinctive triple helix of polysaccharide, which was similar to the structure of commercially available xylan. Xylan was effectively and workably extracted from corn cob by the DES method. This study provided a new approach for high value conversion of corn cob and the clean production of xylan.
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- 2024
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58. Cancer survival analysis on population-based cancer registry data in Zhejiang Province, China (2018–2019)
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Huizhang Li, Youqing Wang, Weiwei Gong, Chen Zhu, Le Wang, Yaoyao Chen, Lingbin Du, and Xiangdong Cheng
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Cancer registry ,Cancer survival ,Hybrid analysis ,Relative survival ,Net survival ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective: This is a comprehensive overview of long-term cancer survival in Zhejiang Province, China. Hybrid analysis, a combination of cohort and period analysis, has been proposed to derive up-to-date cancer survival estimates. Using this approach, we aimed to timely and accurately analyze the 5-year relative survival (RS) and net survival (NS) in cancer registries of Zhejiang Province, China. Methods: A total of 255,725 new cancer cases diagnosed during 2013–2017 were included in 14 cancer registries in Zhejiang Province, China, with a follow-up on vital status until the end of 2019. The hybrid analysis was used to calculate the 5-year RS and 5-year NS during 2018–2019 for overall and stratifications by sex, cancer type, region, and age at diagnosis. Results: During 2018–2019, the age-standardized 5-year RS and NS for overall cancer in Zhejiang was 47.5% and 48.6%, respectively. The age-standardized 5-year RS for cancers of women (55.4%) was higher than that of men (40.0%), and the rate of urban areas (49.7%) was higher than that of rural areas (43.1%). The 5-year RS declined along with age, from 84.4% for ages 74 years. Our results of the RS and NS showed the similar trend and no significant difference. The top five cancers with top age-standardized 5-year RS were thyroid cancer (96.0%), breast cancer (84.3%), testicular cancer (79.9%), prostate cancer (77.2%), and bladder cancer (70.6%), and the five cancers with the lowest age-standardized 5-year RS were pancreatic cancer (6.0%), liver cancer (15.6%), gallbladder cancer (17.1%), esophageal cancer (22.7%), and leukemia (31.0%). Conclusions: We reported the most up-to-date 5-year cancer RS and NS in Zhejiang Province, China for the first time, and found that the 5-year survival for cancer patients in Zhejiang during 2018–2019 was relatively high. The population-based cancer registries are recognized as key policy tools that can be used to evaluate both the impact of cancer prevention strategies and the effectiveness of health systems.
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- 2024
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59. Development and validation of a novel risk classification tool for predicting long length of stay in NICU blood transfusion infants
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Nurbiya Arkin, Ting Zhao, Yanqing Yang, and Le Wang
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Blood transfusion infants ,Long length of stay (LOS) ,Prediction nomogram ,Medicine ,Science - Abstract
Abstract Newborns are as the primary recipients of blood transfusions. There is a possibility of an association between blood transfusion and unfavorable outcomes. Such complications not only imperil the lives of newborns but also cause long hospitalization. Our objective is to explore the predictor variables that may lead to extended hospital stays in neonatal intensive care unit (NICU) patients who have undergone blood transfusions and develop a predictive nomogram. A retrospective review of 539 neonates who underwent blood transfusion was conducted using median and interquartile ranges to describe their length of stay (LOS). Neonates with LOS above the 75th percentile (P75) were categorized as having a long LOS. The Least Absolute Shrinkage and Selection Operator (LASSO) regression method was employed to screen variables and construct a risk model for long LOS. A multiple logistic regression prediction model was then constructed using the selected variables from the LASSO regression model. The significance of the prediction model was evaluated by calculating the area under the ROC curve (AUC) and assessing the confidence interval around the AUC. The calibration curve is used to further validate the model’s calibration and predictability. The model’s clinical effectiveness was assessed through decision curve analysis. To evaluate the generalizability of the model, fivefold cross-validation was employed. Internal validation of the models was performed using bootstrap validation. Among the 539 infants who received blood transfusions, 398 infants (P75) had a length of stay (LOS) within the normal range of 34 days, according to the interquartile range. However, 141 infants (P75) experienced long LOS beyond the normal range. The predictive model included six variables: gestational age (GA) (
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- 2024
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60. Organic Geochemical Evidence for the Formation of Condensate from Coaly Source Rocks in the Wumaying Buried Hill of the Huanghua Depression, Bohai Bay Basin
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Da Lou, LE Wang, Rong Luo, Jinjun Xu, Yongge Sun, Feipeng Zhang, Yonggang Zhao, Hui Wang, and Jiacheng Ge
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Chemistry ,QD1-999 - Published
- 2024
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61. The relative and combined ability of stress hyperglycemia ratio and N-terminal pro-B-type natriuretic peptide to predict all-cause mortality in diabetic patients with multivessel coronary artery disease
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Le Wang, Chen Wang, Jia-chun Lang, Rong-di Xu, Hong‑liang Cong, Jing‑xia Zhang, Yue‑cheng Hu, Ting-ting Li, Chun-wei Liu, Hua Yang, and Wen‑yu Li
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Stress hyperglycemia ratio ,N-terminal pro-B-type natriuretic peptide ,Long-term mortality ,Diabetes ,Multivessel disease ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Stress hyperglycemia ratio (SHR) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are independently associated with increased mortality risk in diabetic patients with coronary artery disease (CAD). However, the role of these biomarkers in patients with diabetes and multivessel disease (MVD) remains unknown. The present study aimed to assess the relative and combined abilities of these biomarkers to predict all-cause mortality in patients with diabetes and MVD. Methods This study included 1148 diabetic patients with MVD who underwent coronary angiography at Tianjin Chest Hospital between January 2016 and December 2016. The patients were divided into four groups according to their SHR (SHR-L and SHR-H) and NT-proBNP (NT-proBNP-L and NT-proBNP-H) levels. The primary outcome was all-cause mortality. Multivariate Cox regression analyses were performed to evaluate the association of SHR and NT-proBNP levels with all-cause mortality. Results During a mean 4.2 year follow-up, 138 patients died. Multivariate analysis showed that SHR and NT-proBNP were strong independent predictors of all-cause mortality in diabetic patients with MVD (SHR: HR hazard ratio [2.171; 95%CI 1.566–3.008; P
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- 2024
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62. Emergence of quantum confinement in topological kagome superconductor CsV3Sb5
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Yongqing Cai, Yuan Wang, Zhanyang Hao, Yixuan Liu, Xuelei Sui, Zuowei Liang, Xiao-Ming Ma, Fayuan Zhang, Zecheng Shen, Chengcheng Zhang, Zhicheng Jiang, Yichen Yang, Wanling Liu, Qi Jiang, Zhengtai Liu, Mao Ye, Dawei Shen, Han Gao, Hanbo Xiao, Zhongkai Liu, Zhe Sun, Yi Liu, Shengtao Cui, Jiabin Chen, Le Wang, Cai Liu, Junhao Lin, Bing Huang, Zhenyu Wang, Xianhui Chen, Jia-Wei Mei, Jianfeng Wang, and Chaoyu Chen
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract Quantum confinement is a restriction on the motion of electrons in a material to specific region, resulting in discrete energy levels rather than continuous energy bands. In certain materials, quantum confinement could dramatically reshape the electronic structure and properties of the surface with respect to the bulk. Here, in the recently discovered kagome superconductors CsV3Sb5, we unveil the dominant role of quantum confinement in determining their surface electronic structure. Combining angle-resolved photoemission spectroscopy (ARPES) measurement and density-functional theory simulation, we report the observations of two-dimensional quantum well states due to the confinement of bulk electron pocket and Dirac cone to the nearly isolated surface layer. The theoretical calculations on the slab model also suggest that the ARPES observed spectra are almost entirely contributed by the top two layers. Our results not only explain the disagreement of band structures between the recent experiments and calculations, but also suggest an equally important role played by quantum confinement, together with strong correlation and band topology, in shaping the electronic properties of this material.
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- 2024
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63. A Skin-Inspired Self-Adaptive System for Temperature Control During Dynamic Wound Healing
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Yaqi Geng, Guoyin Chen, Ran Cao, Hongmei Dai, Zexu Hu, Senlong Yu, Le Wang, Liping Zhu, Hengxue Xiang, and Meifang Zhu
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Thermo-reception ,Self-regulation ,Flexible electronic system ,Wound healing ,Technology - Abstract
Highlights An interactive electronic system inspired by the temperature self-regulation of human skin. Heat stimulation therapy and temperature monitoring during dynamic wound healing. Mechanism of temperature self-regulation during dynamic wound healing.
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- 2024
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64. Characterization and trajectories of hematological parameters prior to severe COVID-19 based on a large-scale prospective health checkup cohort in western China: a longitudinal study of 13-year follow-up
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Yifei Lin, Yong Yang, Nanyan Xiang, Le Wang, Tao Zheng, Xuejun Zhuo, Rui Shi, Xiaoyi Su, Yan Liu, Ga Liao, Liang Du, and Jin Huang
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Health checkup ,Prospective cohort ,COVID-19 ,Proactive health ,Long term ,Medicine - Abstract
Abstract Background The relaxation of the “zero-COVID” policy on Dec. 7, 2022, in China posed a major public health threat recently. Complete blood count test was discovered to have complicated relationships with COVID-19 after the infection, while very few studies could track long-term monitoring of the health status and identify the characterization of hematological parameters prior to COVID-19. Methods Based on a 13-year longitudinal prospective health checkup cohort of ~ 480,000 participants in West China Hospital, the largest medical center in western China, we documented 998 participants with a laboratory-confirmed diagnosis of COVID-19 during the 1 month after the policy. We performed a time-to-event analysis to explore the associations of severe COVID-19 patients diagnosed, with 34 different hematological parameters at the baseline level prior to COVID-19, including the whole and the subtypes of white and red blood cells. Results A total of 998 participants with a positive SARS-CoV-2 test were documented in the cohort, 42 of which were severe cases. For white blood cell-related parameters, a higher level of basophil percentage (HR = 6.164, 95% CI = 2.066–18.393, P = 0.001) and monocyte percentage (HR = 1.283, 95% CI = 1.046–1.573, P = 0.017) were found associated with the severe COVID-19. For lymphocyte-related parameters, a lower level of lymphocyte count (HR = 0.571, 95% CI = 0.341–0.955, P = 0.033), and a higher CD4/CD8 ratio (HR = 2.473, 95% CI = 1.009–6.059, P = 0.048) were found related to the risk of severe COVID-19. We also observed that abnormality of red cell distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC), and hemoglobin might also be involved in the development of severe COVID-19. The different trajectory patterns of RDW-SD and white blood cell count, including lymphocyte and neutrophil, prior to the infection were also discovered to have significant associations with the risk of severe COVID-19 (all P
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- 2024
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65. Respiratory syncytial virus subtypes in children with bronchiolitis: does it correlate with clinical severity?
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Shuo Yang, Sukun Lu, Yakun Wang, Yinghui Guo, Zhuang Zhang, Weijian Wang, and Le Wang
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Bronchiolitis ,Children ,RSV subtypes ,Outcome ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background In this retrospective study, we aimed to evaluate the factors associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children aged under 2 years who were admitted to the Children’s Hospital of Hebei between June 2018 and January 2019. Methods Sputum samples positive for RSV via multiplex PCR were subtyped using real-time PCR. Data collected included risk factors for disease severity, demographics, microbiology, and outcomes. Results Of the 82 children with RSV bronchiolitis, 79 were treated and discharged with improvement, while 3 died. All three patients had underlying medical conditions, including complex congenital heart disease and severe combined immunodeficiency. Further, disease severity was associated with preexisting underlying disease, fever duration, and bacterial co-infection, but not with the RSV subtype. Conclusions Our findings suggest that an appropriate therapeutic regimen should include the detection of bacterial co-infections and the identification of underlying diseases for the effective management of severe RSV bronchiolitis.
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- 2024
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66. Pan-cancer characterization of cell-free immune-related miRNA identified as a robust biomarker for cancer diagnosis
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Peng Wu, Chaoqi Zhang, Xiaoya Tang, Dongyu Li, Guochao Zhang, Xiaohui Zi, Jingjing Liu, Enzhi Yin, Jiapeng Zhao, Pan Wang, Le Wang, Ruirui Li, Yue Wu, Nan Sun, and Jie He
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Cell-free immune-related miRNAs ,Pan-cancer analysis ,Machine learning algorithms ,Early detection of cancers ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Minimally invasive testing is essential for early cancer detection, impacting patient survival rates significantly. Our study aimed to establish a pioneering cell-free immune-related miRNAs (cf-IRmiRNAs) signature for early cancer detection. We analyzed circulating miRNA profiles from 15,832 participants, including individuals with 13 types of cancer and control. The data was randomly divided into training, validation, and test sets (7:2:1), with an additional external test set of 684 participants. In the discovery phase, we identified 100 differentially expressed cf-IRmiRNAs between the malignant and non-malignant, retaining 39 using the least absolute shrinkage and selection operator (LASSO) method. Five machine learning algorithms were adopted to construct cf-IRmiRNAs signature, and the diagnostic classifies based on XGBoost algorithm showed the excellent performance for cancer detection in the validation set (AUC: 0.984, CI: 0.980–0.989), determined through 5-fold cross-validation and grid search. Further evaluation in the test and external test sets confirmed the reliability and efficacy of the classifier (AUC: 0.980 to 1.000). The classifier successfully detected early-stage cancers, particularly lung, prostate, and gastric cancers. It also distinguished between benign and malignant tumors. This study represents the largest and most comprehensive pan-cancer analysis on cf-IRmiRNAs, offering a promising non-invasive diagnostic biomarker for early cancer detection and potential impact on clinical practice.
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- 2024
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67. Cooperative Cu/azodiformate system-catalyzed allylic C–H amination of unactivated internal alkenes directed by aminoquinoline
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Le Wang, Cheng-Long Wang, Zi-Hao Li, Peng-Fei Lian, Jun-Chen Kang, Jia Zhou, Yu Hao, Ru-Xin Liu, He-Yuan Bai, and Shu-Yu Zhang
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Science - Abstract
Abstract Aliphatic allylic amines are common in natural products and pharmaceuticals. The oxidative intermolecular amination of C(sp3)-H bonds represents one of the most straightforward strategies to construct these motifs. However, the utilization of widely internal alkenes with amines in this transformation remains a synthetic challenge due to the inefficient coordination of metals to internal alkenes and excessive coordination with aliphatic and aromatic amines, resulting in decreasing the reactivity of the catalyst. Here, we present a regioselective Cu-catalyzed oxidative allylic C(sp3)-H amination of internal olefins with azodiformates to these problems. A removable bidentate directing group is used to control the regiochemistry and stabilize the π-allyl-metal intermediate. Noteworthy is the dual role of azodiformates as both a nitrogen source and an electrophilic oxidant for the allylic C-H activation. This protocol features simple conditions, remarkable scope and functional group tolerance as evidenced by >40 examples and exhibits high regioselectivity and excellent E/Z selectivity.
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- 2024
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68. Oligogenic basis of premature ovarian insufficiency: an observational study
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Panpan Long, Le Wang, Hangjing Tan, Ruping Quan, Zihao Hu, Minghua Zeng, Ziheng Deng, Hualin Huang, Jonathan Greenbaum, Hongwen Deng, and Hongmei Xiao
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Whole-exome sequencing ,Gene-burden analysis ,Oligogenic inheritance ,Premature ovarian insufficiency ,ORVAL platform ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background The etiology of premature ovarian insufficiency, that is, the loss of ovarian activity before 40 years of age, is complex. Studies suggest that genetic factors are involved in 20–25% of cases. The aim of this study was to explore the oligogenic basis of premature ovarian insufficiency. Results Whole-exome sequencing of 93 patients with POI and whole-genome sequencing of 465 controls were performed. In the gene-burden analysis, multiple genetic variants, including those associated with DNA damage repair and meiosis, were more common in participants with premature ovarian insufficiency than in controls. The ORVAL-platform analysis confirmed the pathogenicity of the RAD52 and MSH6 combination. Conclusions The results of this study indicate that oligogenic inheritance is an important cause of premature ovarian insufficiency and provide insights into the biological mechanisms underlying premature ovarian insufficiency.
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- 2024
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69. Research Progress on Extraction, Structure Determination, Chemical Modification and Biological Activity of Garlic Polysaccharides
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Shuang DAI, Linlin LI, Wei YIN, Le WANG, Yuwei WANG, and Jian LIANG
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garlic polysaccharide ,extraction ,structure determination ,chemical modification ,biological activity ,Food processing and manufacture ,TP368-456 - Abstract
As one of the main active ingredients of garlic, garlic polysaccharide has many biological activities, such as enhancing immunity, antibacterial, antiviral, antioxidant, hepatoprotective, hypolipidemic, hypoglycemic, etc., and has a broad application prospect. The extraction methods of garlic polysaccharides are most common by hot water method, enzyme method and ultrasound-assisted method. It is found by structural determination that garlic polysaccharide is a heteropolysaccharide composed of fructose, glucose, galactose, mannose, galacturonic acid, etc. Chemical modifications such as acetylation, selenization and phosphorylation can increase the antioxidant and other biological activities of garlic polysaccharide. This paper systematically summarizes the current research status of garlic polysaccharides from the perspectives of extraction, structure determination, chemical modification and bioactivity of garlic polysaccharides, and in the future, attention should be paid to the conformational relationship between polysaccharide structure and bioactivity, and the efficacy mechanism of garlic polysaccharides should be explored in depth, with a view to providing theoretical references for the development and utilization of garlic polysaccharides as functional products.
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- 2024
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70. Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial
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Ya-xi Shang, Shu-feng Wei, Ke-peng Yang, Yuan Liu, Su Wei, Xia Dong, Xin-chang Wang, Zhi-min Xie, Ru-lu Fang, Li-na Liang, Xiu-feng Li, Lei Xu, Mu-zhi Chen, Kai-xian Zhang, Ji-yong Huang, Le Wang, You-guo Yang, Hong-li Liao, Gui-e Xing, Yu-ping Zheng, Xiao-fen Li, Jing-lian Lin, Cheng-qian Shi, Yong-ping Zeng, Li-dan Mo, Fan Sun, Xiao-peng Li, Zhuo Zhang, Kai Chen, Zhao-chun He, and Jian-ping Liu
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Tibetan medicine ,Qingpeng ointment ,Acute gouty arthritis ,Randomized controlled trial ,Integrative medicine ,Pain ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background This study aims to assess the efficacy and safety of Qingpeng ointment (QPO), a Tibetan medicine for alleviating symptoms in individuals with acute gouty arthritis (AGA). Methods This study was a randomized, double-blind, placebo-controlled trial that involved individuals with AGA whose joint pain, as measured on a visual analog scale (VAS) from 0 to 10, was equal to or greater than 3. The participants were randomly assigned to either the QPO or the placebo group and received their respective treatments twice daily for seven consecutive days. In case of intolerable pain, the participants were allowed to use diclofenac sodium sustained-release tablets as a rescue medicine. The primary outcomes measured were joint pain and swelling, while the secondary outcomes included joint mobility, redness, serum uric acid levels, C-reactive protein levels, and the amount of remaining rescue medicine. Any adverse events that occurred during the trial were also recorded. Results A total of 203 cases were divided into two groups, with balanced baselines: 102 in the QPO group and 101 in the placebo group. For joint pain, differences between the groups were notable in the VAS scores [1.75 (0, 3.00) versus 2.00 (1.00, 3.50); P = 0.038], changes in VAS [5.00 (3.00, 6.00) versus 4.00 (2.00, 6.00); P = 0.036], and disappearance rate [26.47% compared to 15.84%; P = 0.046] after treatment. Concerning joint swelling, significant between-group differences were observed in the VAS scores [1.00 (0, 2.30) versus 2.00 (0.70, 3.00); P = 0.032] and disappearance rate [33.33% compared to 21.78%; P = 0.046] at treatment completion. The QPO group exhibited a statistically significant mobility improvement compared to the placebo group (P = 0.004). No significant differences were found in other secondary outcomes. Five patients, four from the QPO group and one from the other, encountered mild adverse events, primarily skin irritation. All of these cases were resolved after dosage reduction or discontinuation of the medication. Conclusions Compared to the placebo, QPO exhibits positive effects on AGA by alleviating pain, reducing swelling, and enhancing joint mobility, without causing significant adverse effects. Trial Registration ISRCTN34355813. Registered on 25/01/2021.
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- 2024
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71. Chromosome-level genome assembly and annotation of the yellow grouper, Epinephelus awoara
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Weiwei Zhang, Yang Yang, Sijie Hua, Qingxin Ruan, Duo Li, Le Wang, Xi Wang, Xin Wen, Xiaochun Liu, and Zining Meng
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Science - Abstract
Abstract Epinephelus awoara, as known as yellow grouper, is a significant economic marine fish that has been bred artificially in China. However, the genetic structure and evolutionary history of yellow grouper remains largely unknown. Here, this work presents the high-quality chromosome-level genome assembly of yellow grouper using PacBio single molecule sequencing technique (SMRT) and High-through chromosome conformation capture (Hi-C) technologies. The 984.48 Mb chromosome-level genome of yellow grouper was assembled, with a contig N50 length of 39.77 Mb and scaffold N50 length of 41.39 Mb. Approximately 99.76% of assembled sequences were anchored into 24 pseudo-chromosomes with the assistance of Hi-C reads. Furthermore, approximately 41.17% of the genome was composed of repetitive elements. In total, 24,541 protein-coding genes were predicted, of which 22,509 (91.72%) genes were functionally annotated. The highly accurate, chromosome-level reference genome assembly and annotation are crucial to the understanding of population genetic structure, adaptive evolution and speciation of the yellow grouper.
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- 2024
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72. The association of lymphocyte with hypothyroidism in obstructive sleep apnea
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Xiaoyan Fang, Le Wang, Chong Xu, Tuai Xue, Mingchu Zhang, Lingling Liu, Jie Cao, and Jing Zhang
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Obstructive sleep apnea ,Hypothyroidism ,Lymphocyte ,Hashimoto's thyroiditis ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Purpose Obstructive sleep apnea (OSA) is a common sleep-breathing disorder. Numerous investigations have found a strong inherent relationship between OSA and hypothyroidism. Studies suggest that lymphocytes may be involved in the development of hypothyroidism in patients with OSA. This study aimed to assess the association between lymphocytes and hypothyroidism in OSA patients. Patients and methods This study involved 920 patients with OSA who underwent nocturnal sleep monitoring, thyroid function testing, and routine blood tests. In patients with OSA, logistic regression analysis indicated independent predictors of hypothyroidism. The cutoff level of lymphocyte count was determined using a receiver operating characteristic (ROC) analysis to predict the occurrence of hypothyroidism in individuals with OSA. Results This study comprised 920 OSA patients (617 males and 303 women), 879 with normal thyroid function, and 41 with hypothyroidism, with a hypothyroidism incidence of 4.46%. In the entire OSA population and male OSA patients, the number of lymphocytes was significantly higher in the hypothyroid group than in the control group (p = 0.002 and 0.020, respectively). In addition, among the OSA population younger than 60 years old and patients with mild to moderate OSA, lymphocytes were found to be considerably more in the hypothyroid group than in the euthyroid group. Lymphocyte count, ESS, and sex were all independent predictors of hypothyroidism development in OSA patients. According to ROC curve analysis, the risk of hypothyroidism increases with increasing lymphocyte count in the total patient population, with an optimal diagnostic cutoff point of 2.5 (× 10*9/L). Conclusions The prevalence of hypothyroidism in patients with OSA increases as the number of lymphocytes increases. Lymphocyte count can be used as an independent predictor of the occurrence of hypothyroidism, and it has a diagnostic value for OSA combined with hypothyroidism.
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- 2024
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73. Skeletal muscle index together with body mass index is associated with secondary osteoporosis in patients with rheumatoid arthritis
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Yi-ran Chu, Yue-chen Xu, Ling-li Ma, Jian-xiong Wang, He-xiang Zong, Wan-qiu Tong, Xi-le Wang, Xu Zhao, and Sheng-qian Xu
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Rheumatoid arthritis ,Sarcopenia ,Osteoporosis ,Body composition ,Medicine - Abstract
Abstract Objective The objective of this study was to explore the associations of body mass index (BMI), fat mass index (FMI), skeletal mass index (SMI) and secondary osteoporosis (OP) in patients with rheumatoid arthritis (RA). Methods The bone mineral density (BMD) at sites of the femur neck (Neck), total hip (Hip) and lumbar vertebrae 1–4 (L1-4) was measured by dual-energy X-ray absorptiometry. The skeletal muscle index, body fat percentage and mineral content were measured by biological electrical impedance for calculating BMI, FMI and SMI. Results A total of 433 patient with RA and 158 healthy controls were enrolled. The BMDs at each site of the RA patients were lower compared with those of the healthy controls (p
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- 2024
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74. Portable robots for upper-limb rehabilitation after stroke: a systematic review and meta-analysis
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Kevin C. Tseng, Le Wang, Chunkai Hsieh, and Alice M. Wong
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Portability ,stroke ,robotics ,exoskeleton ,hand and upper extremity rehabilitation ,Medicine - Abstract
AbstractBackground Robot-assisted upper-limb rehabilitation has been studied for many years, with many randomised controlled trials (RCTs) investigating the effects of robotic-assisted training on affected limbs. The current trend directs towards end-effector devices. However, most studies have focused on the effectiveness of rehabilitation devices, but studies on device sizes are relatively few.Goal Systematically review the effect of a portable rehabilitation robot (PRR) on the rehabilitation effectiveness of paralysed upper limbs compared with non-robotic therapy.Methods A meta-analysis was conducted on literature that included the Fugl-Meyer Assessment (FMA) obtained from the PubMed and Web of Science (WoS) electronic databases until June 2023.Results A total of 9 studies, which included RCTs, were completed and a meta-analysis was conducted on 8 of them. The analysis involved 295 patients. The influence on upper-limb function before and after treatment in a clinical environment is analysed by comparing the experimental group using the portable upper-limb rehabilitation robot with the control group using conventional therapy. The result shows that portable robots prove to be effective (FMA: SMD = 0.696, 95% = 0.099 to.293, p
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- 2024
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75. Can Telemedicine Improve Offline Healthcare Accessibility? Evidence from Empirical Research in China.
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Zilong Wang, Hualong Yang, Le Wang, and Wai-Ki Sung
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- 2024
76. Can the Dual-Channel Healthcare Model Alleviate the Problem of 'Difficult and Expensive Access to Medical Care'?
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Zilong Wang, Hualong Yang, Le Wang, and Wai-Ki Sung
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- 2024
77. The Impact of Physician's Social Support on Patient Engagement in Free Live-Streamed Medical Consultation.
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Haochen Song, Le Wang, and Xitong Guo
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- 2024
78. Nitrogen use efficiency of drip irrigated sugar beet as affected by sub-optimal levels of nitrogen and irrigation
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Hongliang Zhou, Le Wang, Pengjie Xu, Dongfei Liu, Lijuan Zhang, Yuchen Hao, Kaiyong Wang, and Hua Fan
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Daily water consumption ,Daily nitrogen uptake ,N use efficiency ,Fertilizer-15N ,Agriculture (General) ,S1-972 ,Agricultural industries ,HD9000-9495 - Abstract
Sugar beet has strong drought resistance and requires a large amount of nitrogen (N) during growth. Can deficit irrigation combined with low N supply of sugar beet improve water productivity (WP) and N use efficiency (NUE)? In this field study in 2020–2021, two irrigation regimes (W1, field capacity (FC) of the 0–60 cm soil layer was not lower than 70% from 45 days after emergence (DAE) to harvest period; W2, FC of the 0–60 cm soil layer was not lower than 50% in 45–90 DAE, but was consistent with that of W1 after 90 DAE) and three N application rates (0 (N0), 150 (N1), and 225 (N2) kg N ha−1) were designed. Then, their impacts on taproot yield (TY), water consumption (WC) and N uptake (NU) were explored. The results showed that there was no significant difference in TY between W2 and W1 treatments under the N1 and N2 levels. Under the N1 and N2 levels, the daily water consumption (DWC, 0.121 and 0.125 mm ℃d−1) and daily N uptake (DNU, 53.6 and 71.6 g N ℃d−1) of W2 treatment were significantly lower than the DWC (0.161 and 0.164 mm ℃d−1) and DNU (60.6 and 86.5 g N ℃d−1) of W1 treatment in 0–90 DAE. The W2N1 treatment had similar WP and higher NUE compared with the W1N2 treatment. In addition, the fertilizer-15N recovery rate in W2N1 treatment was 8.8% higher than that in W1N2 treatment, the fertilizer-15N loss rate was 6.6% lower than that in W1N2 treatment, but there was no difference in the fertilizer-15N residue between the two. This study clarified that implementing W2 deficit irrigation (50% FC at the canopy rapid growth stage (45–90 DAE)) and N1 nitrogen application rate (33% nitrogen reduction based on 225 kg N ha−1) could not reduce TY but improve WP and NUE.
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- 2024
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79. Decoding the immune landscape: a comprehensive analysis of immune-associated biomarkers in cervical carcinoma and their implications for immunotherapy strategies
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Le Wang, Huatian Liu, Yue Feng, Xueting Liu, Yuan Wang, Yujie Liu, Hao Li, and Yunyan Zhang
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CESC ,TIME ,ICI therapy ,IRGPI ,therapeutic target ,Genetics ,QH426-470 - Abstract
Background and aimsCervical cancer, a prevalent gynecological malignant tumor, poses a significant threat to women’s health and lives. Immune checkpoint inhibitor (ICI) therapy has emerged as a promising avenue for treating cervical cancer. For patients with persistent or recurrent metastatic cervical cancer, If the sequence of dead receptor ligand-1 (PD-L1) is positive, ICI show significant clinical efficacy. PD-L1 expression serves as a valuable biomarker for assessing ICI therapeutic efficacy. However, the complex tumor immune microenvironment (TIME), encompassing immune cell composition and tumor-infiltrating lymphocyte (TIL) status, also exerts a profound influence on tumor immunity and prognosis. Given the remarkable strides made by ICI treatments in improving the survival rates of cervical cancer patients, it becomes essential to identify a comprehensive biomarker that integrates various TIME aspects to enhance the effectiveness of ICI treatment. Therefore, the quest for biomarkers linked to multiple facets of TIME in cervical cancer is a vital pursuit.MethodsIn this study, we have developed an Immune-Associated Gene Prognostic Index (IRGPI) with remarkable prognostic value specifically for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). The Cancer Genome Atlas CESC dataset (n = 305) was meticulously analyzed to pinpoint key immune-related genes via weighted gene co-expression network analysis and differential gene expression assays. Subsequently, we employed Cox regression analysis to construct the IRGPI. Furthermore, the composition of immune cells and TIL status were examined using CIBERSORT and TIDE. Tumor expression of Epigen, LCN10, and P73 were determined with immunohistochemistry.ResultsThe resulting IRGPI, composed of EPGN, LCN10, and TP73 genes, displayed a strong negative correlation with patient survival. The discovery was validated with a patient cohort from our hospital. The IRGPI not only predicts the composition of immune cell subtypes such as Macrophages M1, NK cells, Mast cells, Plasma cells, Neutrophils, Dendritic cells, T cells CD8, and T cells CD4 within CESC, but also indicates TIL exclusion, dysfunction, and PD-1 and PD-L1 expression. Therefore, the IRGPI emerges as a promising biomarker not only for prognostic assessment but also for characterizing multiple immune features in CESC. Additionally, our results underscored the significant associations between the IRGPI and immune cell composition, TIL exclusion, and dysfunction, along with PD-1 and PD-L1 expression in the TIME.ConclusionConsequently, the IRGPI stands out as a biomarker intimately connected to both the survival and TIME status of CESC patients, offering potential insights into immunotherapy strategies for CESC.
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- 2024
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80. Enhanced quantum secret sharing protocol for anonymous secure communication utilizing W states
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Guo-Dong Li, Wen-Chuan Cheng, Qing-Le Wang, Long Cheng, Ying Mao, and Heng-Yue Jia
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Quantum measurement ,Applied sciences ,Computer security and privacy ,Science - Abstract
Summary: Quantum secret sharing (QSS) represents the fusion of quantum mechanics principles with secret information sharing, allowing a sender to distribute a secret among receivers for collective recovery. This paper introduces the concept of quantum anonymous secret sharing (QASS) to enhance the practicality of such protocols. We propose a QASS protocol leveraging W states, ensuring both recover-security and anonymity of shared secrets. Our protocol undergoes rigorous evaluation verifying their accuracy and fortifying their security against scenarios involving the active adversary. Additionally, acknowledging the imperfections inherent in real-world communication channels, we conduct a comprehensive analysis of protocol security and efficacy in noisy quantum networks. Our investigations reveal that W states exhibit good performance in mitigating noise interference, making them apt for practical applications.
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- 2024
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81. Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials
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Xiao-ying Chen, Chun-li Lu, Qian-yun Wang, Xing-ru Pan, Yang-yang Zhang, Jia-le Wang, Jun-Ya Liao, Nai-chong Hu, Chen-yang Wang, Bing-jie Duan, Xue-han Liu, Xin-yan Jin, Jennifer Hunter, and Jian-ping Liu
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Post COVID condition ,Chronic fatigue ,Traditional medicine ,Complementary medicine ,Integrative medicine ,Miscellaneous systems and treatments ,RZ409.7-999 - Abstract
Background: Chronic fatigue is a predominant symptom of post COVID-19 condition, or long COVID. We aimed to evaluate the efficacy and safety of Traditional, Complementary and Integrative Medicine (TCIM) for fatigue post COVID-19 infection. Methods: Ten English and Chinese language databases and grey literature were searched up to 12 April 2023 for randomized controlled trials (RCTs). Cochrane “Risk of bias” (RoB) tool was applied. Evidence certainty was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Effect estimates were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). Results: Thirteen RCTs with 1632 participants were included. One RCT showed that Bufei Huoxue herbal capsules reduced fatigue (n=129, MD -14.90, 95%CI -24.53 to -5.27), one RCT reported that Ludangshen herbal liquid lowered fatigue (n=184, MD -1.90, 95%CI -2.38 to -1.42), and the other one RCT shown that fatigue disappearance rate was higher with Ludangshen herbal liquid (n=184, RR 4.19, 95%CI 2.06 to 8.53). Compared to traditional Chinese medicine rehabilitation (TCM-rahab) alone, one RCT showed that fatigue symptoms were lower following Qingjin Yiqi granules plus TCM-rehab (n=388, MD -0.48, 95%CI -0.50 to -0.46). Due to concerns with RoB and/or imprecision, the certainty in this evidence was low to very low. No serious adverse events was reported. Conclusions: Limited evidence suggests that various TCIM interventions might reduce post COVID-19 fatigue. Larger, high quality RCTs of longer duration are required to confirm these preliminary findings. Study Registration: The protocol of this review has been registered at PROSPERO: CRD42022384136.
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- 2024
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82. A framework for functional zoning of national parks based on biocultural diversity assessment
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Xifa Song, Yuting Wu, Siyu Chen, Le Wang, Diechuan Yang, Wei Zhang, and Nan Liu
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Biocultural diversity ,Coupling coordination degree model ,National parks ,Functional zoning ,Kunlun Mountains National Park ,Ecology ,QH540-549.5 - Abstract
Reasonable zoning is essential for maintaining the integrity and stability of natural ecosystems and achieving multi-goal management of national parks, and can facilitate efficient management and protection of various resources. Biocultural diversity is an important result and outstanding representation of human-land relationships, directly affecting the resilience of socio-ecological systems. Taking Kunlun Mountains National Park in Qinghai Province (KMNP) as an example, we transformed the dualistic conservation model of biology and culture, and the Coupling Coordination Degree Model (CCDM) was used to establish a technical framework for the functional zoning of national parks based on the collaborative protection of biological diversity and cultural diversity. The research results indicated that biocultural diversity and its coupling relationship of KMNP are relatively good, with high coupling areas mainly dominated by cultural diversity and low coupling areas mainly by biological diversity. The research suggests that KMNP should be divided into 4 functional zones: strict protection area, ecological conservation area, traditional utilization area, and comprehensive development area. These findings provide references for the planning and construction of national parks and reserves around the world, to unleash their transformative potential in addressing global biodiversity loss.
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- 2024
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83. Timely delivery of bone marrow mesenchymal stem cells based on the inflammatory pattern of bone injury environment to promote the repair of calvarial bone defects in rats: An optimized strategy for bone tissue engineering
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Yuwei Zeng, Aiju Lou, Zhenmin Zhong, Yu Cai, Yixi Yang, Haifeng Liang, Yucong Lin, Zhuoxuan He, Lei Zhou, Zhi-Yong Zhang, and Le Wang
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Biochemistry ,QD415-436 - Abstract
Stem cell-based therapy plays a significant role in the repair of bone defects. However, traditional stem cell transplantation strategies in bone tissue engineering are characterized by low survival rates and unstable treatment outcomes. In this study, we propose a timely delivery strategy for inflammatory changes in the setting of bone injury to improve the survival rate of transplanted cells and bone repair. The results of cell tracing in vivo showed that this strategy could effectively improve the survival rate of low-dose exogenous transplanted cells in bone defect areas, and CD31 immunofluorescence and histological sections suggested that this strategy effectively promoted vascularization and new bone formation in the calvarial defect area. Subsequently, we analyzed the mechanism of action of the “Two-step” strategy from the perspective of inflammatory microenvironment regulation, and the results suggested that the first batch transplanted stem cells caused localized and transient increases in tissue apoptosis levels and inflammatory factors, and recruited macrophage chemotaxis, and the second batch of cells may promote pro-inflammatory - anti-inflammatory transformation of the tissue. Finally, mRNA sequencing results suggest that the first batch cells in the “Two-step” strategy are important initiators in bone repair, which not only actively regulate the immune microenvironment at the bone defect, but also guide richer cellular activity and more positive biochemical responses. Therefore, the “Two-step” strategy leads to efficient inflammatory environment regulation and superior bone repair effects, which may provide an alternative option for the treatment of bone defects in the future.
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- 2024
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84. The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts
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Kexin Li, Wenzhen Liu, Changhui Wu, Le Wang, Yunmei Huang, Ye Li, Huimin Zheng, Yanyu Shang, Lei Zhang, and Zhuo Chen
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Ganoderma lucidum extract ,anti-Fatigue activity ,Sleep-aiding activity ,Glycogen levels ,Serum lactic acid ,Serum urea nitrogen ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Aims: This study aims to delve into the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum extracts. Materials and methods: PGB [incorporating Ganoderma lucidum extract (GE), broken Ganoderma lucidum spore powder (GB) and Paecilomyces hepiali mycelium (PH)] and GBS [composed of GE, GB, and Ganoderma sinense powder (GS)] were chosen as representative recipes for this study. Mice were treated with these recipes or key components of Ganoderma lucidum for 14 consecutive days. Subsequently, a weight-bearing swimming experiment was conducted to assess the mice's exhaustion time and evaluate the anti-fatigue properties of the recipes. Sleep-aiding effects were analyzed by measuring the sleep latency and duration. Furthermore, levels of blood lactic acid, serum urea nitrogen, hepatic glycogen, muscle glycogen, and malondialdehyde (MDA) were measured in the livers and muscles. Key findings: The anti-fatigue abilities of the tested mice were significantly improved after treatment with PGB and their sleep quality improved as well with GBS treatment. PGB treatment for 14 days could significantly prolong the exhaustion time in weight-bearing swimming (from 10.1 ± 0.5 min to 15.2 ± 1.3 min). Meanwhile, glycogen levels in the livers and muscles were significantly increased, while the levels of serum lactic acid, serum urea nitrogen, and MDA in the livers and muscles were significantly decreased. In contrast, mice treated with GBS for 14 days experienced significant improvements in sleep quality, with shortened sleep latency (from 6.8 ± 0.7 min to 4.2 ± 0.4 min), extended sleep duration (from 88.3 ± 1.4 min to 152.5 ± 9.3 min), and decreased muscle MDA levels. These results indicated that Ganoderma lucidum extracts can be used for anti-fatigue and or aid in sleeping, depending on how they are prepared and administered. Significance: This study provides experimental evidence and theoretical basis for the development of Ganoderma lucidum recipes that are specifically designed to help with anti-fatigue and sleep.
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- 2024
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85. Theabrownin from Qingzhuan tea prevents high-fat diet-induced MASLD via regulating intestinal microbiota
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Yong Chen, Chen Xie, Yining Lei, Dan Ye, Le Wang, Fang Xiong, Hui Wu, Qiang He, Hongfu Zhou, Ling Li, Jun Xing, Cai Wang, and Min Zheng
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Theabrownin ,MASLD ,Obesity ,Intestinal microbiota ,Short-chain fatty acids ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The aim of this study was to investigate whether the therapeutic effect of theabrownin extracted from Qingzhuan tea (QTB) on metabolic dysfunction-associated steatosis liver disease (MASLD) is related to the regulation of intestinal microbiota and its metabolite short-chain fatty acids (SCFAs). Mice were divided into four groups and received normal diet (ND), high-fat diet (HFD) and HFD+QTB (180, 360 mg/kg) for 8 weeks. The results showed that QTB significantly reduced the body weight of HFD mice, ameliorated liver lipid and dyslipidemia, and increased the level of intestinal SCFAs in HFD mice. The results of 16 S rRNA showed that the relative abundance of Bacteroides, Blautia and Lachnoclostridium and their main metabolites acetate and propionate were significantly increased after QTB intervention. The relative abundance of Colidextribacter, Faecalibaculum and Lactobacillus was significantly reduced. QTB can also significantly up-regulate the expression of ATGL, PPARα, FFAR2 and FFAR3, and inhibit the expression of LXRα, SREBP-1c, FAS and HMGCR genes. This makes it possible to act as a prebiotic to prevent MASLD.
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- 2024
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86. Effect of heat stress on blood biochemistry and energy metabolite of the Dazu black goats
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Le Wang, Pengjun Zhang, Yuxuan Du, Changtong Wang, Li Zhang, Li Yin, Fuyuan Zuo, and Wenming Huang
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heat stress ,Dazu black goat ,physiological indicators ,hormonal ,amino acids ,Veterinary medicine ,SF600-1100 - Abstract
The objective of this study was to determine the effects of heat stress (HS) on physiological, blood biochemical, and energy metabolism in Dazu black goats. Six wether adult Dazu black goats were subjected to 3 experimental periods: high HS (group H, temperature-humidity index [THI] > 88) for 15 d, moderate HS (group M, THI was 79-88) for 15 d, and no HS (group L, THI < 72) for 15 d. Rectal temperature (RT) and respiratory rate (RR) were determined on d 7 and 15 of each period, and blood samples were collected on d 15 of each period. All goats received glucose (GLU) tolerance test (GTT) and insulin (INS) tolerance test on d 7 and d 10 of each period. The results showed that HS decreased dry matter intake (DMI) and INS concentrations (p 0.05) and 40.78% (p 0.05) during the ITT. A total of 60 differentially expressed metabolites were identified in response to groups H and M. In HS, changes in metabolites related to carbohydrate metabolism and glycolysis were identified (p
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- 2024
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87. Effect of Prosocial Behaviors on e-Consultations in a Web-Based Health Care Community: Panel Data Analysis
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Xiaoxiao Liu, Huijing Guo, Le Wang, Mingye Hu, Yichan Wei, Fei Liu, and Xifu Wang
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundPatients using web-based health care communities for e-consultation services have the option to choose their service providers from an extensive digital market. To stand out in this crowded field, doctors in web-based health care communities often engage in prosocial behaviors, such as proactive and reactive actions, to attract more users. However, the effect of these behaviors on the volume of e-consultations remains unclear and warrants further exploration. ObjectiveThis study investigates the impact of various prosocial behaviors on doctors’ e-consultation volume in web-based health care communities and the moderating effects of doctors’ digital and offline reputations. MethodsA panel data set containing information on 2880 doctors over a 22-month period was obtained from one of the largest web-based health care communities in China. Data analysis was conducted using a 2-way fixed effects model with robust clustered SEs. A series of robustness checks were also performed, including alternative measurements of independent variables and estimation methods. ResultsResults indicated that both types of doctors’ prosocial behaviors, namely, proactive and reactive actions, positively impacted their e-consultation volume. In terms of the moderating effects of external reputation, doctors’ offline professional titles were found to negatively moderate the relationship between their proactive behaviors and their e-consultation volume. However, these titles did not significantly affect the relationship between doctors’ reactive behaviors and their e-consultation volume (P=.45). Additionally, doctors’ digital recommendations from patients negatively moderated both the relationship between doctors’ proactive behaviors and e-consultation volume and the relationship between doctors’ reactive behaviors and e-consultation volume. ConclusionsDrawing upon functional motives theory and social exchange theory, this study categorizes doctors’ prosocial behaviors into proactive and reactive actions. It provides empirical evidence that prosocial behaviors can lead to an increase in e-consultation volume. This study also illuminates the moderating roles doctors’ digital and offline reputations play in the relationships between prosocial behaviors and e-consultation volume.
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- 2024
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88. Ginkgolide injections in meglumine, combined with edaravone, significantly increases the efficacy in acute ischemic stroke: A meta-analysis
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Mingyuan Yan, Jing Wu, Le Wang, Kaiyue Wang, Lili Li, Tianye Sun, Han Zhang, Mi Zhang, Lin Zou, Songyi Yang, and Jinmin Liu
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diterpene ginkgolides meglumine injection ,traditional Chinese medicine ,acute ischemic stroke ,NIHSS ,meta-analysis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
ObjectiveThis study aimed to evaluate the efficacy of combining diterpene ginkgolide meglumine injection (DGMI) with edaravone for the treatment of acute ischemic stroke. This is particularly relevant because Western drugs, excluding intravenous thrombolysis, have shown limited success.MethodsA comprehensive search was conducted using multiple databases, including PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure WanFang, VIP, and Chinese Biomedical Database (CBM) until June 2023. The data were analyzed using fixed-effects and random-effects models in Review Manager. The mean difference with 95% confidence interval was calculated for each outcome.ResultsEighteen studies involving 1,636 participants were included in the analysis. The DGMI group showed significant reductions in the National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale (mRS) score, and C-reactive protein (CRP) level, compared to the control group. Furthermore, the DGMI group showed a significant improvement in superoxide dismutase (SOD) levels and a reduction in malondialdehyde (MDA) levels. The combination of DGMI and edaravone was more effective in reducing neuron-specific enolase (NSE) levels following brain tissue injury than edaravone alone. Additionally, DGMI complemented edaravone in reducing rheological parameters associated with ischemic stroke, including hematocrit, plasma viscosity, platelet adhesion rate, and erythrocyte deformation index.ConclusionThe combination of DGMI and edaravone significantly improved the therapeutic efficacy in patients with acute ischemic stroke. However, more extensive and high-quality clinical trials are required to validate these underlying mechanisms.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=260215, identifier: PROSPERO (CRD42021260215)
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- 2024
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89. Rapid response to fifth-line brigatinib plus entrectinib in an ALK-rearranged lung adenocarcinoma with an acquired ETV6-NTRK3 fusion: a case report
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Dan Li, Yue Zhu, Jincheng Song, Dafu Yang, Saiqiong Cui, Xin Liu, Le Wang, Jiangyan Zhang, Evenki Pan, and Zhaoxia Dai
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ALK rearrangement ,brigatinib ,entrectinib ,resistance mutations ,ETV6-NTRK3 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The management of non-small cell lung cancer (NSCLC), specifically targeting the anaplastic lymphoma kinase (ALK) with tyrosine kinase inhibitors (TKIs), is challenged by the emergence of therapeutic resistance. Resistance mechanisms to ALK TKIs can be broadly classified into ALK-dependent and ALK-independent pathways. Here, we present a case with lung adenocarcinoma (LUAD) harboring an ALK rearrangement. The patient had developed resistance to sequential ALK TKI therapies, with an acquired ETV6-NTRK3 (E4:N14) fusion as a potential mechanism of ALK-independent resistance to lorlatinib. Subsequently, the patient was treated with the combination of brigatinib plus entrectinib and demonstrated a positive response, achieving an 8-month progression-free survival. Our case provides a potential treatment option for LUAD patients with ALK rearrangements and highlights the utility of next-generation sequencing (NGS) in uncovering genetic alterations that can guide the selection of effective treatment strategies.
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- 2024
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90. Controlled growth of single-crystalline 2D p-type semiconductor α-MnSe for broadband photodetector
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Meijie Zhu, Xiaojian Wang, Zuoquan Tan, Kai Li, Qingliang Feng, Li Chen, and Le Wang
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2D α-MnSe ,CVD ,P-type semiconductor ,Broadband photodetector ,Physics ,QC1-999 - Abstract
As a wide band-gap p-type semiconductor, α-MnSe has been expected to make up for the scarcity of two-dimensional (2D) semiconductor materials, which is crucial for the construction of multifunctional and miniaturized p-n junctions. Herein, we report the synthesis of single crystalline α-MnSe with its domain size, thickness and coverage controlled by hydrogen modulated CVD. The back-gate FET device was fabricated to study the electrical properties of α-MnSe. Moreover, the α-MnSe-based photodetector exhibits a broadband photo-response ranging from 532 nm to 980 nm with response times as low as ∼ 20 ms, comparable to most 2D materials.
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- 2024
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91. Study on interdigital flow field structure and two phase flow characteristics of PEM electrolyzer
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Jianxin, Liu, Le, Wang, Xiaolei, Zhang, Gulizhaina, Habudula, Xuedi, Chai, and Lihua, Huang
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- 2024
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92. Test of the colonization ability of the invasive alien plant Flaveria bidentis (Asteraceae) in southern China
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Xin-Chen, Li, Xi, Chen, Xue-jing, Dong, Lai-Le, Wang, Li, Yi-chen, Zhi-Hua, Shi, Xiao-ling, Song, Sheng, Qiang, Wei-min, Dai, and Dai, Wei-Min
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- 2023
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93. Selective pyrophosphate detection via metal complexes
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Xiao Zhang, Wenwen Sun, Le Wang, Zeping Xie, Mengxia Liu, and Junfeng Wang
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fluorescence ,imaging ,metal complex ,pyrophosphate (PPi) ,sensor ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Pyrophosphate (PPi) anions are crucial in numerous biological and ecological processes involved in energy conversion, enzymatic reactions, and metabolic regulation along with adenosine. They are also significant biological markers for various processes related to diseases. Fluorescent PPi sensors would enable visual and/or biological detection in convenient settings. However, the current availability of commercial sensors has been limited to costly enzymes that are not compatible for imaging. Sensor development has also encountered challenges such as poor selectivity and stability and limited practical applications. In this review, we analyze the situation of PPi sensing via commercial kits and focus on sensors that use metal complexes. We address their designs, sensing mechanisms, selectivities, and detection limits. Finally, we discuss limitations and perspectives for PPi detection and imaging.
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- 2023
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94. Single-Cell RNA-Sequencing Integration Analysis Revealed Immune Cell Heterogeneity in Five Human Autoimmune Diseases
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Siweier Luo, Le Wang, Yi Xiao, Chunwei Cao, Qinghua Liu, and Yiming Zhou
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autoimmune disease ,iga nephropathy ,kawasaki disease ,multiple sclerosis ,single cell rna sequencing ,sjogren’s syndrome ,systemic lupus erythematosus ,Medicine - Abstract
Background: Autoimmune diseases are a group of diseases caused by abnormal immune responses to functional body parts. Single-cell RNA-sequencing (scRNA-seq) technology provides transcriptomic information at the single-cell resolution, thus offering a new way to study autoimmune diseases. Most single-cell RNA-seq studies, however, have often focused on one type of autoimmune disease. Methods: We integrated scRNA-seq data from peripheral blood cells of five different autoimmune diseases (IgA nephropathy [IgAN], Kawasaki disease [KD], multiple sclerosis [MS], Sjogren’s syndrome [SS], and systemic lupus erythematosus [SLE]). We performed dimensionality clustering, cellular communication analysis, re-clustering analysis of monocytes, NK cell populations, differential gene expression analysis, and functional enrichment for all immune cells in these data. Results: We integrated the scRNA-seq results of peripheral blood cells from five different autoimmune diseases (IgAN, KD, MS, SS, and SLE). We showed that all samples contained 18 different immune cell subsets, although the cell cluster populations were different among the 5 diseases. Through intercellular communication network analysis, we determined that the signals of classical and non-classical monocytes were significantly enhanced in patients with IgAN and SLE. The signals of naïve B cells were increased in patients KD. Interestingly, the signals of NK and NK-T cells were enhanced in patients with SS, but reduced in patients with IgAN and SLE. Transcriptomic analysis of classical and non-classical monocyte subsets further revealed that pro-inflammatory cytokines and interferon-related genes, including CCL3, IL1B, ISG15, and IFI6, were specifically increased in patients with IgAN and SLE. Unlike monocytes, the number and NK marker genes were decreased in patients with IgAN and KD, but increased in patients with SS. Meanwhile, two NK-T cell subsets were exclusively found in SS. Conclusions: In summary, based on an integration of the single-cell RNA-seq results, we demonstrated changes in the immune cell landscape of five different autoimmune diseases with respect to immune cell subsets, populations, differentially-expressed genes, and the cell-to-cell communication network. Our data provide new insight to further explore the heterogeneity and similarity among different autoimmune diseases.
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- 2023
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95. Integrating serum metabolomics and network analysis to explore the antidepressant activity of crocin in rats with chronic unexpected mild stress-induced depression
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Yan Luo, Ziyan Zhong, Huan Li, Le Wang, Dongwei Guo, Xuanqi Dong, Jian Liu, Mingxia Xie, Mei Wu, Yun Xiang, Xi Zhang, and Pan Meng
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Traditional Chinese medicine ,untargeted metabolomics ,network pharmacology ,interaction network ,metabolism ,Therapeutics. Pharmacology ,RM1-950 - Abstract
AbstractContext Crocin exhibits anti-depressant properties. However, its underlying mechanisms and its relationship with metabolomics remain unclear.Objective This study elucidates the mechanism of action and potential targets of crocin in treating chronic unexpected mild stress (CUMS)-induced depression in rats.Materials and methods Male Sprague-Dawley (SD) rats underwent 4 weeks of CUMS to establish the depression model. The normal control (distilled water), crocin (25 mg/kg), and fluoxetine (5.4 mg/kg) groups were orally administered for 4-weeks. Behavioural tests evaluated the effects of crocin, while liquid chromatography-mass spectrometry metabolomics identified differential metabolites and their associated metabolic pathways. Subsequently, network pharmacology was utilized to predict the targets of crocin.Results Crocin significantly increased body weight (from 319.16 ± 4.84 g to 325.67 ± 2.84 g), sucrose preference (from 0.46 ± 0.09 to 0.70 ± 0.09), vertical activity (from 2.83 ± 1.94 to 8 ± 2.36), horizontal activity (from 1 ± 0.63 to 4.5 ± 3.08) and decreased immobilization time (from 13.16 ± 2.69 to 3.97 ± 3.00). Metabolomics analysis identified 7 metabolites and 5 associated metabolic pathways. From the combined analysis of network pharmacology and metabolomics, three targets (PRMT1, CYP3A4, and GLB1) are the overlapping targets and the two most important metabolic pathways are tryptophan metabolism and glycerolipid metabolism.Discussion and conclusions This study provides insights into the antidepressant therapeutic effect of crocin and its underlying mechanisms. The findings contribute to a better understanding of the metabolic mechanism involved in the anti-depressant effect of crocin, establishing a strong foundation for future research in this area.
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- 2023
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96. Middle and near ultraviolet spectrograph of the Scientific Experimental system in Near SpacE (SENSE)
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Xin Sun, DaLian Shi, Zhen Chen, Ran Li, WeiWei Cao, Jun Zhu, YongLin Bai, Le Wang, and Fei He
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ultraviolet spectrograph ,radiation background ,imaging grating ,intensified detector ,low-pressure discharge ,spectral calibration ,Science ,Geophysics. Cosmic physics ,QC801-809 ,Environmental sciences ,GE1-350 - Abstract
The Scientific Experimental system in Near SpacE (SENSE) consists of different types of instruments that will be installed on a balloon-based platform to characterize near-space environmental parameters. As one of the main scientific payloads, the middle and near ultraviolet spectrograph (MN-UVS) will provide full spectra coverage from middle ultraviolet (MUV, 200−300 nm) to near ultraviolet (NUV, 300−400 nm) with a spectral resolution of 2 nm. Its primary mission is to acquire data regarding the UV radiation background of the upper atmosphere. The MN-UVS is made up of six primary components: a fore-optical module, an imaging grating module, a UV intensified focal plane module, a titanium alloy frame, a spectrometer control module, and a data processing module. This paper presents in detail the engineering design of each functional unit of the MN-UVS, as well as the instrument’s radiometric calibration, wavelength calibration, impact test, and low-pressure discharge test. Furthermore, we are able to report ground test and flight test results of high quality, showing that the MN-UVS has a promising future in upcoming near-space applications.
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- 2023
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97. Front-line therapy for brain metastases and non-brain metastases in advanced epidermal growth factor receptor-mutated non-small cell lung cancer: a network meta-analysis
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Yixiang Zhu, Chengcheng Liu, Ziyi Xu, Zihua Zou, Tongji Xie, Puyuan Xing, Le Wang, Junling Li, Xiangxiang Pan, and Peifang Wei
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Medicine - Abstract
Abstract. Background:. The brain is a common metastatic site in patients with non-small cell lung cancer (NSCLC), resulting in a relatively poor prognosis. Systemic therapy with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) is recommended as the first-line treatment for EGFR-mutated, advanced NSCLC patients. However, intracranial activity varies in different drugs. Thus, brain metastasis (BM) should be considered when choosing the treatment regimens. We conducted this network meta-analysis to explore the optimal first-line therapeutic schedule for advanced EGFR-mutated NSCLC patients with different BM statuses. Methods:. Randomized controlled trials focusing on EGFR-TKIs (alone or in combination) in advanced and EGFR-mutant NSCLC patients, who have not received systematic treatment, were systematically searched up to December 2021. We extracted and analyzed progression-free survival (PFS) and overall survival (OS). A network meta-analysis was performed with the Bayesian statistical model to determine the survival outcomes of all included therapy regimens using the R software. Hazard ratios (HRs) and 95% confidence intervals (CIs) were used to compare intervention measures, and overall rankings of therapies were estimated under the Bayesian framework. Results:. This analysis included 17 RCTs with 5077 patients and 12 therapies, including osimertinib + bevacizumab, aumolertinib, osimertinib, afatinib, dacomitinib, standards of care (SoC, including gefitinib, erlotinib, or icotinib), SoC + apatinib, SoC + bevacizumab, SoC + ramucirumab, SoC + pemetrexed based chemotherapy (PbCT), PbCT, and pemetrexed free chemotherapy (PfCT). For patients with BM, SoC + PbCT improved PFS compared with SoC (HR = 0.40, 95% CI: 0.17–0.95), and osimertinib + bevacizumab was most likely to rank first in PFS, with a cumulative probability of 34.5%, followed by aumolertinib, with a cumulative probability of 28.3%. For patients without BM, osimertinib + bevacizumab, osimertinib, aumolertinib, SoC + PbCT, dacomitinib, SoC + ramucirumab, SoC + bevacizumab, and afatinib showed superior efficacy compared with SoC (HR = 0.43, 95% CI: 0.20–0.90; HR = 0.46, 95% CI: 0.31–0.68; HR = 0.51, 95% CI: 0.34–0.77; HR = 0.50, 95% CI: 0.38–0.66; HR = 0.62, 95% CI: 0.43–0.89; HR = 0.64, 95% CI: 0.44–0.94; HR = 0.61, 95% CI: 0.48–0.76; HR = 0.71, 95% CI: 0.50–1.00), PbCT (HR = 0.29, 95% CI: 0.11–0.74; HR = 0.31, 95% CI: 0.15–0.62; HR = 0.34, 95% CI: 0.17–0.69; HR = 0.34, 95% CI: 0.18–0.64; HR = 0.42, 95% CI: 0.21–0.82; HR = 0.43, 95% CI: 0.22–0.87; HR = 0.41, 95% CI: 0.22–0.74; HR = 0.48, 95% CI: 0.31–0.75), and PfCT (HR = 0.14, 95% CI: 0.06–0.32; HR = 0.15, 95% CI: 0.09–0.26; HR = 0.17, 95% CI: 0.09–0.29; HR = 0.16, 95% CI: 0.10–0.26; HR = 0.20, 95% CI: 0.12–0.35; HR = 0.21, 95% CI: 0.12–0.39; HR = 0.20, 95% CI: 0.12–0.31; HR = 0.23, 95% CI: 0.16–0.34) in terms of PFS. And, SoC + apatinib showed relatively superior PFS when compared with PbCT (HR = 0.44, 95% CI: 0.22–0.92) and PfCT (HR = 0.21, 95% CI: 0.12–0.39), but similar PFS to SoC (HR = 0.65, 95% CI: 0.42–1.03). No statistical differences were observed for PFS in patients without BM between PbCT and SoC (HR = 1.49, 95% CI: 0.84–2.64), but both showed favorable PFS when compared with PfCT (PfCT vs. SoC, HR = 3.09, 95% CI: 2.06–4.55; PbCT vs. PfCT, HR = 0.14, 95% CI: 0.06–0.32). For patients without BM, osimertinib + bevacizumab was most likely to rank the first, with cumulative probabilities of 47.1%. For OS, SoC + PbCT was most likely to rank first in patients with and without BM, with cumulative probabilities of 46.8%, and 37.3%, respectively. Conclusion:. Osimertinib + bevacizumab is most likely to rank first in PFS in advanced EGFR-mutated NSCLC patients with or without BM, and SoC + PbCT is most likely to rank first in OS.
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- 2023
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98. Mechanical properties and corrosion behavior of precipitation-strengthened FeCoNi-Tix (x = 0, 3, 6 at. %) multi-principal element alloys
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HaoWei Deng, Yan Jiang, BoKai Liao, Zhuan Zhao, Le Wang, and Tao Zhang
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FeCoNi–Ti ,MPEAs ,Mechanical property ,Corrosion behavior ,L12-type Ni3Ti precipitate ,Mining engineering. Metallurgy ,TN1-997 - Abstract
This study investigated the influence of adding different titanium contents (0, 3, 6 at. %) and controlling nanoscale L12-type Ni3Ti precipitates through hot-forge and heat treatment on the mechanical and corrosion behavior of FeCoNi medium-entropy alloys. It was found that, when the Ti atom is in a solid solution state, the degree of lattice distortion increases, and the corrosion resistance decreased with increasing Ti content. Whether in the solid solution state or the precipitate state, increasing the Ti content effectively enhanced the strength of FeCoNi alloy. The strengthening effect was particularly prominent in the precipitate state compared to the solid solution state. The experimental results provided valuable references for the design and preparation of other high-strength, tough, and corrosion-resistant multi-principal element alloys.
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- 2023
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99. Damage predictive model of submarine pipeline impacted by falling object based on BP neural network
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Chunhui ZHANG, Wenhao ZHAO, Yinghui TIAN, Xixian NIU, Le WANG, Xin HUANG, Hongyu SHE, and Xiaoliang QI
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ocean engineering ,submarine pipe damage ,falling object impact ,bp neural network ,predictive model ,saturated clay seabed ,undrained shear strength ,Technology - Abstract
In order to predict the damage of submarine pipeline on saturated clay seabed by falling objects, a dynamic finite element model of interaction between saturated clay seabed and submarine pipeline under the impact of falling objects was established. The influence of six parameters, namely, energy of falling objects, diameter of the pipeline, wall thickness, grade of the steel material, internal pressure, and undrained shear strength of seabed soil on the damage of the submarine pipeline was analyzed by combining with the range of changes of the actual working conditions of the submarine pipeline. Taking the six parameters as input parameters, the damage of pipeline as output parameters, and the numerical simulation results as training samples, a BP neural network model for submarine pipeline damage prediction was constructed through learning and training. The results show that the larger the impact energy of the falling object is, the larger the pipeline damage is, and the pipeline damage growth rate tends to slow down with the increase in the impact energy of the falling object. The increase in pipeline diameter, wall thickness, internal pressure, and the pipeline yield strength leads to a decrease in the pipeline damage. The saturated soil undrained shear strength increases, while pipe damage increases. The established BP neural network prediction model for submarine pipe damage needs only six parameters, namely, falling object impact energy, pipe diameter, wall thickness, steel grade, internal pressure and undrained shear strength of seabed soil. It is simple and convenient, and can better predict the damage of submarine pipeline impacted by falling objects in saturated clay seabed. The numerical examples cover the working conditions of common saturated clay seabed submarine pipelines, so the model has good applicability, which provides new ideas for the prediction of submarine pipeline damage.
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- 2023
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100. Bacillus coagulant HYI (BC-HYI) Alleviates LPS-Elicited Oxidative Stress by Engaging the Nrf2/HO-1 Signaling Pathway and Regulates Gut Macrobiotics in Laying Chickens
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Tianhang Lu, Le Wang, Qiong Wu, Hua Zhang, Defeng Cui, Bowen Liu, Jinjin Tong, and Yonghong Zhang
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probiotics ,oxidative stress ,Nrf2-ARE/HO-1 signaling ,laying chickens ,Microbiology ,QR1-502 - Abstract
In the current study, Bacillus coagulants had a role in combating oxidative stress by inhibiting the growth of intestinal pathogens. However, there are few studies on reducing the mechanisms of oxidative stress. Therefore, this study aimed to explore the effects and underlying mechanisms of B. coagulant HYI (BC-HYI) treatment on growth and intestinal functions in laying chickens under LPS-induced oxidative stress. The in vivo experimental group included five groups of laying chicks: normal control, LPS group, B6 group, B7 group and B8 group. The test consisted of six repetitions in each group, with six animals in each repetition. In the in vitro experiment, an LPS-induced oxidative stress model of chicken fibroblast DF-1 cells was established, and the DF-1 cells were divided into control group, LPS-treated group, B5 group, B6 group and B7 group. On the one hand, we found that BC-HYI can inhibit pathological changes in some intestinal tissues. On the other hand, BC-HYI supplementation has a dual effect on the gut microbiota, promoting the proliferation of beneficial microbes such as Barbarella, Lactobacillus, and Antibacterial while maintaining symbiotic balance. The abundance of Barbarella, Bactericide, and Cloistral was significantly different between the LPS group and the BC-HYI group (p < 0.01). Moreover, compared with the LPS group, BC-HYI significantly decreased reactive oxygen species levels and prevented cell apoptosis (p < 0.01). It used to prevent oxidative stress by activating the Nrf2-ARE/HO-1 signaling pathway, enhancing the scavenging of free radicals, and reducing oxidative damage. BC-HYI alleviated oxidative stress in laying chickens by modulating the gut microbiota and activating the Nrf2-ARE/HO-1 signaling pathway. In summary, laying chickens and cell experiments indicate that BC-HYI supplementation can improve the enzyme function of antioxidants, regulate intestinal barrier function and activate the Nrf2-ARE/HO-1 signaling pathway to regulate intestinal barrier function.
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- 2023
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