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G-protein-coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage-restricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which documents novel roles for GPCR signaling components in GPCR-independent signaling in macrophages. In particular, we examine the crosstalk between GPCR and TLR signaling pathways and highlight GPCR signaling molecules which are likely to have uncharacterized functions in this cell lineage.

The family Anthocoridae (Hemiptera:Heteroptera) contains between 400 and 600 species distributed worldwide, chiefly on the continents but also on oceanic islands. They are small (1.4-4.5 mm) and common to a wide variety of habitats. Many are found in cryptic habitats such as galls, several widespread genera are surface feeders on small arthropods (Anthocoris, Orius, and Tetraphleps), and others can be found in ant nests and, especially, under bark. Wing polymorphism is common in this family, often associated with the cryptic habit. Most known species are predaceous, though some take plant food as well (e.g. Orius insidiosus, Orius pallidicornis). A few of these are believed to be entirely phytophagous (Paratriphleps laeviusculus). Their small size and often generalized feeding habits have resulted in about 30 introduced species, mostly accidental. A few have been introduced deliberately as biological control agents (Anthocoris spp., Montandoniola moraguesi, O. insidiosus, Orius tristicolor, and Tetraphleps spp.). Most nonindigenous species seem to have been distributed as a result of human activities, especially commerce. The predaceous habits of many Anthocoridae have attracted the attention of researchers who work in agroecosystems. Integrated pest management programs often include these predators, which has given us greater knowledge about these species than those found in natural ecosystems. Exciting discoveries about the attractiveness to these bugs of certain volatile plant and arthropod compounds are opening new areas of investigation into their chemical ecology. The reactions of these tiny predators will surely become better understood as a result.