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51. Coronary plaque quantification and fractional flow reserve by coronary computed tomography angiography identify ischaemia-causing lesions

Author

Gaur, Sara, Øvrehus, Kristian Altern, Dey, Damini, Leipsic, Jonathon, Bøtker, Hans Erik, Jensen, Jesper Møller, Narula, Jagat, Ahmadi, Amir, Achenbach, Stephan, Ko, Brian S., Christiansen, Evald Høj, Kaltoft, Anne Kjer, Berman, Daniel S., Bezerra, Hiram, Lassen, Jens Flensted, and Nørgaard, Bjarne Linde

Published
2016
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53. Efficacy and safety of zotarolimus-eluting and sirolimus-eluting coronary stents in routine clinical care (SORT OUT III): a randomised controlled superiority trial

Author

Rasmussen, Klaus, Maeng, Michael, Kaltoft, Anne, Thayssen, Per, Kelbæk, Henning, Tilsted, Hans Henrik, Abildgaard, Ulrik, Christiansen, Evald Høj, Engstrøm, Thomas, Krusell, Lars Romer, Ravkilde, Jan, Hansen, Peter Riis, Hansen, Knud Nørregaard, Abildstrøm, Steen Zabell, Aarøe, Jens, Jensen, Jan Skov, Kristensen, Steen Dalby, Bøtker, Hans Erik, Madsen, Morten, Johnsen, Søren Paaske, Jensen, Lisette Okkels, Sørensen, Henrik Toft, Thuesen, Leif, and Lassen, Jens Flensted

Published
2010
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54. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial

Author

Bøtker, Hans Erik, Kharbanda, Rajesh, Schmidt, Michael R, Bøttcher, Morten, Kaltoft, Anne K, Terkelsen, Christian J, Munk, Kim, Andersen, Niels H, Hansen, Troels M, Trautner, Sven, Lassen, Jens Flensted, Christiansen, Evald Høj, Krusell, Lars R, Kristensen, Steen D, Thuesen, Leif, Nielsen, Søren S, Rehling, Michael, Sørensen, Henrik Toft, Redington, Andrew N, and Nielsen, Torsten T

Published
2010
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57. 287 Association of lactate and lactate clearance with favourable neurological outcome in cardiac arrest patients managed with extracorporeal cardiopulmonary resuscitation

Author

Gregers, Emilie, Thevathasan, Tharusan, Mørk, Sivagowry Rasalingam, Linde, Louise, Andreasen, Jo Bønding, Degbeon, Sêhnou, Smerup, Morten Holdgaard, Hassager, Christian, Møller, Jacob Eifer, Laugesen, Helle, Terkelsen, Christian Juhl, Lassen, Jens Flensted, Søholm, Helle, and Skurk, Carsten

Published
2023
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58. Randomized comparison of a sirolimus-eluting Orsiro stent with a biolimus-eluting Nobori stent in patients treated with percutaneous coronary intervention: Rationale and study design of the Scandinavian Organization for Randomized Trials with Clinical Outcome VII trial

Author

Jensen, Lisette Okkels, Thayssen, Per, Maeng, Michael, Ravkilde, Jan, Hansen, Henrik Steen, Jensen, Svend Eggert, Btker, Hans Erik, Berencsi, Klára, Lassen, Jens Flensted, and Christiansen, Evald Hj

Published
2015
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61. 2-Year Clinical Outcomes After Implantation of Sirolimus-Eluting, Paclitaxel-Eluting, and Bare-Metal Coronary Stents: Results From the WDHR (Western Denmark Heart Registry)

Author

Kaltoft, Anne, Jensen, Lisette Okkels, Maeng, Michael, Tilsted, Hans Henrik, Thayssen, Per, Bøttcher, Morten, Lassen, Jens Flensted, Krusell, Lars Romer, Rasmussen, Klaus, Hansen, Knud Nørregaard, Pedersen, Lars, Johnsen, Søren Paaske, Sørensen, Henrik Toft, and Thuesen, Leif

Published
2009
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65. The European bifurcation club Left Main Coronary Stent study: a randomized comparison of stepwise provisional vs. systematic dual stenting strategies (EBC MAIN)

Author

Hildick-Smith, David, primary, Egred, Mohaned, additional, Banning, Adrian, additional, Brunel, Philippe, additional, Ferenc, Miroslaw, additional, Hovasse, Thomas, additional, Wlodarczak, Adrian, additional, Pan, Manuel, additional, Schmitz, Thomas, additional, Silvestri, Marc, additional, Erglis, Andreis, additional, Kretov, Evgeny, additional, Lassen, Jens Flensted, additional, Chieffo, Alaide, additional, Lefèvre, Thierry, additional, Burzotta, Francesco, additional, Cockburn, James, additional, Darremont, Olivier, additional, Stankovic, Goran, additional, Morice, Marie-Claude, additional, and Louvard, Yves, additional

Published
2021
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66. 'The significant other': Evaluation of side branch ostial compromise in bifurcation stenting

Author

Iles, Tinen L., Stankovic, Goran, and Lassen, Jens Flensted

Subjects
Fractional Flow Reserve, Myocardial, Editorial, Percutaneous Coronary Intervention, Coronary Stenosis, Humans, Stents, Coronary Artery Disease, Coronary Angiography, Coronary Vessels
Abstract

The side branch (SB) compromise after main vessel (MV) stenting remains a significant problem in coronary bifurcation treatment. Currently the two major hypotheses for the mechanism of SB compromise are carina shift from MV into the SB and plaque shift into the ostium of side vessel. It is proposed herein, SB ostial deformation leading to reshaping of the ostium from circle to ellipse is a third possible mechanism. In the current study, the theoretical effects and correlation of ostial deformation with fractional flow reserve (FFR) is explored.Based on angiographic measurements and theoretical analysis formulas, three different SB ostial areas using circular ostial shape assumption and elliptical ostial shape assumption were calculated. Three different types of ostial areas with FFR values after MV stenting in 49 patients from the FIESTA registry were compared and analyzed.It was found that there is significant overestimation of stenosis severity when estimated by the circle formula, than with the ellipse formula - ASc vs. ASds with 25% ± 13%, p0.001, ASc vs. ASmld with 9% ± 10%, p0.001. The elliptical shape assumptions provide more accurate ostial area stenosis, which correlates better with FFR. This finding is more significant in less severe stenosis (70% area stenosis) than in a more severe one.A third possible mechanism of SB compromise after MV stenting of coronary bifurcation stenosis is elliptical ostial deformation at the ostium of SBs. The ostial area, calculated based on elliptical assumption correlates better with FFR, than area stenosis calculated with the traditional circular formula.

Published
2020

68. System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention

Author

Terkelsen, Christian Juhl, Sorensen, Jacob Thorsted, Maeng, Michael, Jensen, Lisette Okkels, Tilsted, Hans-Henrik, Trautner, Sven, Vach, Werner, Johnsen, Soren Paaske, Thuesen, Leif, and Lassen, Jens Flensted

Subjects
Angioplasty -- Health aspects, Angioplasty -- Patient outcomes, Heart attack -- Care and treatment, Regression analysis -- Usage
Abstract

A study was conducted to evaluation the relationship between system delay and mortality in patients with ST-segment elevation myocardial infarction (STEMI) that are being treated with primary percutaneous coronary intervention (PCI). Results indicated that in the case of such patients treated with PCI, system delay was associated with mortality.

Published
2010

69. Prehospital Ticagrelor in ST-Segment Elevation Myocardial Infarction

Author

Montalescot, Gilles, van ʼt Hof, Arnoud W., Lapostolle, Frédéric, Silvain, Johanne, Lassen, Jens Flensted, Bolognese, Leonardo, Cantor, Warren J., Cequier, Ángel, Chettibi, Mohamed, Goodman, Shaun G., Hammett, Christopher J., Huber, Kurt, Janzon, Magnus, Merkely, Béla, Storey, Robert F., Zeymer, Uwe, Stibbe, Olivier, Ecollan, Patrick, Heutz, Wim M.J.M., Swahn, Eva, Collet, Jean-Philippe, Willems, Frank F., Baradat, Caroline, Licour, Muriel, Tsatsaris, Anne, Vicaut, Eric, and Hamm, Christian W.

Published
2014
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72. Scintigraphic evaluation of routine filterwire distal protection in percutaneous coronary intervention for acute ST-segment elevation myocardial infarction: a randomized controlled trial

Author

Kaltoft, Anne, Nielsen, Søren Steen, Terkelsen, Christian Juhl, Bøttcher, Morten, Lassen, Jens Flensted, Krusell, Lars Romer, Kristensen, Steen Dalby, Ravkilde, Jan, Kelbæk, Henning, Bøtker, Hans Erik, Christiansen, Evald Høj, Rehling, Michael, and Thuesen, Leif

Published
2009
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73. Percutaneous coronary intervention for bifurcation coronary lesions: the 15th consensus document from the European Bifurcation Club

Author

Burzotta, Francesco, primary, Lassen, Jens Flensted, additional, Lefèvre, Thierry, additional, Banning, Adrian P., additional, Chatzizisis, Yiannis S., additional, Johnson, Thomas William, additional, Ferenc, Miroslaw, additional, Rathore, Sudhir, additional, Albiero, Remo, additional, Pan, Manuel, additional, Darremont, Olivier, additional, Hildick-Smith, David, additional, Chieffo, Alaide, additional, Zimarino, Marco, additional, Louvard, Yves, additional, and Stankovic, Goran, additional

Published
2021
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74. Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study

Author

Erlinge, David, primary, Maehara, Akiko, additional, Ben-Yehuda, Ori, additional, Bøtker, Hans Erik, additional, Maeng, Michael, additional, Kjøller-Hansen, Lars, additional, Engstrøm, Thomas, additional, Matsumura, Mitsuaki, additional, Crowley, Aaron, additional, Dressler, Ovidiu, additional, Mintz, Gary S, additional, Fröbert, Ole, additional, Persson, Jonas, additional, Wiseth, Rune, additional, Larsen, Alf Inge, additional, Okkels Jensen, Lisette, additional, Nordrehaug, Jan Erik, additional, Bleie, Øyvind, additional, Omerovic, Elmir, additional, Held, Claes, additional, James, Stefan K, additional, Ali, Ziad A, additional, Muller, James E, additional, Stone, Gregg W, additional, Ahlehoff, Ole, additional, Amin, Azad, additional, Angerås, Oskar, additional, Appikonda, Praveen, additional, Balachandran, Saranya, additional, Barvik, Ståle, additional, Bendix, Kristoffer, additional, Bertilsson, Maria, additional, Boden, Ulrika, additional, Bogale, Nigussie, additional, Bonarjee, Vernon, additional, Calais, Fredrik, additional, Carlsson, Jörg, additional, Carstensen, Steen, additional, Christersson, Christina, additional, Christiansen, Evald Høj, additional, Corral, Maria, additional, De Backer, Ole, additional, Dhaha, Usama, additional, Dworeck, Christian, additional, Eggers, Kai, additional, Elfström, Charlotta, additional, Ellert, Julia, additional, Eriksen, Erlend, additional, Fallesen, Christian, additional, Forsman, Margareta, additional, Fransson, Helena, additional, Gaballa, Mohsen, additional, Gacki, Marek, additional, Götberg, Matthias, additional, Hagström, Lars, additional, Hallberg, Theresa, additional, Hambraeus, Kristina, additional, Haraldsson, Inger, additional, Harnek, Jan, additional, Havndrup, Ole, additional, Hegbom, Knut, additional, Heigert, Matthias, additional, Helqvist, Steffen, additional, Herstad, Jon, additional, Hijazi, Ziad, additional, Holmvang, Lene, additional, Ioanes, Dan, additional, Iqbal, Amjid, additional, Iversen, Allan, additional, Jacobson, Jaclyn, additional, Jakobsen, Lars, additional, Jankovic, Ivana, additional, Jensen, Ulf, additional, Jensevik, Karin, additional, Johnston, Nina, additional, Jonasson, Torfi Fjalar, additional, Jørgensen, Erik, additional, Joshi, Francis, additional, Kajermo, Ulf, additional, Kåver, Frida, additional, Kelbæk, Henning, additional, Kellerth, Thomas, additional, Kish, Mitra, additional, Koenig, Wolfgang, additional, Koul, Sasha, additional, Lagerqvist, Bo, additional, Larsson, Bertil, additional, Lassen, Jens Flensted, additional, Leiren, Olav, additional, Li, Zhe, additional, Lidell, Christer, additional, Linder, Rikard, additional, Lindstaedt, Michael, additional, Lindström, Gunilla, additional, Liu, Shen, additional, Løland, Kjetil Halvorsen, additional, Lønborg, Jacob, additional, Márton, László, additional, Mir-Akbari, Habib, additional, Mohamed, Shameema, additional, Odenstedt, Jacob, additional, Ogne, Christer, additional, Oldgren, Jonas, additional, Olivecrona, Göran, additional, Östlund-Papadogeorgos, Nikolas, additional, Ottesen, Michael, additional, Packer, Erik, additional, Palmquist, Åsa Michelgård, additional, Paracha, Quratulain, additional, Pedersen, Frans, additional, Petursson, Petur, additional, Råmunddal, Truls, additional, Rotevatn, Svein, additional, Sanchez, Raquel, additional, Sarno, Giovanna, additional, Saunamäki, Kari I, additional, Scherstén, Fredrik, additional, Serruys, Patrick W, additional, Sjögren, Iwar, additional, Sørensen, Rikke, additional, Srdanovic, Iva, additional, Subhani, Zuka, additional, Svensson, Eva, additional, Thuesen, Anne, additional, Tijssen, Jan, additional, Tilsted, Hans-Henrik, additional, Tödt, Tim, additional, Trovik, Thor, additional, Våga, Bjørn Inge, additional, Varenhorst, Christoph, additional, Veien, Karsten, additional, Vestman, Emma, additional, Völz, Sebastian, additional, Wallentin, Lars, additional, Wykrzykowska, Joanna, additional, Zagozdzon, Leszek, additional, Zamfir, Manuela, additional, Zedigh, Crister, additional, Zhong, Hang, additional, and Zhou, Zhipeng, additional

Published
2021
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76. Percutaneous Coronary Intervention For Bifurcation Coronary Lesions.The 15th Consensus Document from the European Bifurcation Club

Author

Burzotta, Francesco, Lassen, Jens Flensted, Lefèvre, Thierry, Banning, Adrian P., Chatzizisis, Yiannis S., Johnson, Thomas W., Ferenc, Miroslaw, Rathore, Sudhir, Albiero, Remo, Pan, Manuel, Darremont, Olivier, Hildick-Smith, David, Chieffo, Alaide, Zimarino, Marco, Louvard, Yves, and Stankovic, Goran

Subjects
Consensus, Optical coherence tomography, pci, Coronary Artery Disease, Coronary Angiography, Bifurcation Coronary Lesions, Treatment Outcome, Percutaneous Coronary Intervention, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Left main, Humans, Bifurcation, Stents, Drug-eluting stent, Drug-eluting balloon, Coronary Artery Disease/diagnostic imaging
Abstract

The 15th European Bifurcation Club (EBC) meeting was held in Barcelona in October 2019. It facilitated a renewed consensus on coronary bifurcation lesions (CBL) and unprotected left main (LM) percutaneous interventions. Bifurcation stenting techniques continue to be refined, developed and tested. It remains evident that a provisional approach with optional side branch treatment utilising T, T and small protrusion (TAP) or culotte continues to provide flexible options for the majority of CBL patients. Debate persists regarding the optimal treatment of side branches, including assessment of clinical significance and thresholds for bail-out treatment. In more complex CBL, especially those involving the LM, adoption of dedicated two-stent techniques should be considered. Operators using such techniques have to be fully familiar with their procedural steps and should acknowledge associated limitations and challenges. When using two-stent techniques, failure to perform a final kissing inflation is regarded as a technical failure, since it may jeopardise clinical outcome. The development of novel technical tools and drug regimens deserves attention. In particular, intracoronary imaging, bifurcation simulation, drug-eluting balloon technology and tailored antiplatelet therapy have been identified as promising tools to enhance clinical outcomes. In conclusion, the evolution of a broad spectrum of bifurcation PCI components has resulted from studies extending from bench testing to randomised controlled trials. However, further advances are still needed to achieve the ambitious goal of optimising the clinical outcomes for every patient undergoing PCI on a CBL. Visual summary. 15th consensus document from the European Bifurcation Club.

Published
2020

79. Asia Pacific consensus document on coronary bifurcation interventions

Author

Loh, Poay Huan, primary, Lassen, Jens Flensted, additional, Jepson, Nigel, additional, Koo, Bon-Kwon, additional, Chen, Shaoliang, additional, Harding, Scott A., additional, Hu, Fenghuan, additional, Lo, Sidney, additional, Ahmad, Wan Azman Wan, additional, Ye, Fei, additional, Guagliumi, Giulio, additional, Hiremath, Murugesh Shantaveeraya, additional, Uemura, Shiro, additional, Wang, Lefeng, additional, Whelan, Alan, additional, and Low, Adrian, additional

Published
2020
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82. 2012 ESC STEMI guidelines and reperfusion therapy: Evidence base ignored, threatening optimal patient management

Author

Terkelsen, Christian Juhl, Pinto, Duane S, Thiele, Holger, Clemmensen, Peter, Nikus, Kjell, Lassen, Jens Flensted, Hildick-Smith, David, Christiansen, Evald Høj, Aarøe, Jens, Hansen, Hans-Henrik Tilsted, Stankovic, Goran, Junker, Anders, Sianos, Georgios, Olivecrona, Göran, Bøtker, Hans Erik, Gibson, Charles Michael, and Boersma, Eric

Published
2013
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85. Ambulance or in-catheterization laboratory administration of ticagrelor for primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Rationale and design of the randomized, double-blind Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery (ATLANTIC) study

Author

Montalescot, Gilles, Lassen, Jens Flensted, Hamm, Christian W., Lapostolle, Frédéric, Silvain, Johanne, ten Berg, Jurriën M., Cantor, Warren J., Goodman, Shaun G., Licour, Muriel, Tsatsaris, Anne, and vanʼt Hof, Arnoud W.

Published
2013
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89. European Bifurcation Club white paper on stenting techniques for patients with bifurcated coronary artery lesions

Author

Burzotta, Francesco, primary, Lassen, Jens Flensted, additional, Louvard, Yves, additional, Lefèvre, Thierry, additional, Banning, Adrian P., additional, Daremont, Olivier, additional, Pan, Manuel, additional, Hildick‐Smith, David, additional, Chieffo, Alaide, additional, Chatzizisis, Yiannis S., additional, Džavík, Vladimír, additional, Gwon, Hyeon‐Cheol, additional, Hikichi, Yutaka, additional, Murasato, Yoshinobu, additional, Koo, Bon Kwon, additional, Chen, Shao‐Liang, additional, Serruys, Patrick, additional, and Stankovic, Goran, additional

Published
2020
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92. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial

Author

Hausenloy, Derek J, primary, Kharbanda, Rajesh K, additional, Møller, Ulla Kristine, additional, Ramlall, Manish, additional, Aarøe, Jens, additional, Butler, Robert, additional, Bulluck, Heerajnarain, additional, Clayton, Tim, additional, Dana, Ali, additional, Dodd, Matthew, additional, Engstrom, Thomas, additional, Evans, Richard, additional, Lassen, Jens Flensted, additional, Christensen, Erika Frischknecht, additional, Garcia-Ruiz, José Manuel, additional, Gorog, Diana A, additional, Hjort, Jakob, additional, Houghton, Richard F, additional, Ibanez, Borja, additional, Knight, Rosemary, additional, Lippert, Freddy K, additional, Lønborg, Jacob T, additional, Maeng, Michael, additional, Milasinovic, Dejan, additional, More, Ranjit, additional, Nicholas, Jennifer M, additional, Jensen, Lisette Okkels, additional, Perkins, Alexander, additional, Radovanovic, Nebojsa, additional, Rakhit, Roby D, additional, Ravkilde, Jan, additional, Ryding, Alisdair D, additional, Schmidt, Michael R, additional, Riddervold, Ingunn Skogstad, additional, Sørensen, Henrik Toft, additional, Stankovic, Goran, additional, Varma, Madhusudhan, additional, Webb, Ian, additional, Terkelsen, Christian Juhl, additional, Greenwood, John P, additional, Yellon, Derek M, additional, Bøtker, Hans Erik, additional, Junker, Anders, additional, Kaltoft, Anne, additional, Madsen, Morten, additional, Christiansen, Evald Høj, additional, Jakobsen, Lars, additional, Carstensen, Steen, additional, Kristensen, Steen Dalby, additional, Thim, Troels, additional, Pedersen, Karin Møller, additional, Korsgaard, Mette Tidemand, additional, Iversen, Allan, additional, Jørgensen, Erik, additional, Joshi, Francis, additional, Pedersen, Frants, additional, Tilsted, Hans Henrik, additional, Alzuhairi, Karam, additional, Saunamäki, Kari, additional, Holmvang, Lene, additional, Ahlehof, Ole, additional, Sørensen, Rikke, additional, Helqvist, Steffen, additional, Mark, Bettina Løjmand, additional, Villadsen, Anton Boel, additional, Raungaard, Bent, additional, Thuesen, Leif, additional, Christiansen, Martin Kirk, additional, Freeman, Philip, additional, Jensen, Svend Eggert, additional, Skov, Charlotte Schmidt, additional, Aziz, Ahmed, additional, Hansen, Henrik Steen, additional, Ellert, Julia, additional, Veien, Karsten, additional, Pedersen, Knud Erik, additional, Hansen, Knud Nørregård, additional, Ahlehoff, Ole, additional, Cappelen, Helle, additional, Wittrock, Daniel, additional, Hansen, Poul Anders, additional, Ankersen, Jens Peter, additional, Hedegaard, Kim Witting, additional, Kempel, John, additional, Kaus, Henning, additional, Erntgaard, Dennis, additional, Pedersen, Danny Mejsner, additional, Giebner, Matthias, additional, Hansen, Troels Martin Hansen, additional, Radosavljevic-Radovanovic, Mina, additional, Prodanovic, Maja, additional, Savic, Lidija, additional, Pejic, Marijana, additional, Matic, Dragan, additional, Uscumlic, Ana, additional, Subotic, Ida, additional, Lasica, Ratko, additional, Vukcevic, Vladan, additional, Suárez, Alfonso, additional, Samaniego, Beatriz, additional, Morís, César, additional, Segovia, Eduardo, additional, Hernández, Ernesto, additional, Lozano, Iñigo, additional, Pascual, Isaac, additional, Vegas-Valle, Jose M., additional, Rozado, José, additional, Rondán, Juan, additional, Avanzas, Pablo, additional, del Valle, Raquel, additional, Padrón, Remigio, additional, García-Castro, Alfonso, additional, Arango, Amalia, additional, Medina-Cameán, Ana B., additional, Fente, Ana I., additional, Muriel-Velasco, Ana, additional, Pomar-Amillo, Ángeles, additional, Roza, César L., additional, Martínez-Fernández, César M., additional, Buelga-Díaz, Covadonga, additional, Fernández-Gonzalo, David, additional, Fernández, Elena, additional, Díaz-González, Eloy, additional, Martinez-González, Eugenio, additional, Iglesias-Llaca, Fernando, additional, Viribay, Fernando M., additional, Fernández-Mallo, Francisco J., additional, Hermosa, Francisco J., additional, Martínez-Bastida, Ginés, additional, Goitia-Martín, Javier, additional, Vega-Fernández, José L., additional, Tresguerres, Jose M., additional, Rodil-Díaz, Juan A., additional, Villar-Fernández, Lara, additional, Alberdi, Lucía, additional, Abella-Ovalle, Luis, additional, de la Roz, Manuel, additional, Fernández-Carral, Marcos Fernández-Carral, additional, Naves, María C., additional, Peláez, María C., additional, Fuentes, María D., additional, García-Alonso, María, additional, Villanueva, María J., additional, Vinagrero, María S., additional, Vázquez-Suárez, María, additional, Martínez-Valle, Marta, additional, Nonide, Marta, additional, Pozo-López, Mónica, additional, Bernardo-Alba, Pablo, additional, Galván-Núñez, Pablo, additional, Martínez-Pérez, Polácido J., additional, Castro, Rafael, additional, Suárez-Coto, Raquel, additional, Suárez-Noriega, Raquel, additional, Guinea, Rocío, additional, Quintana, Rosa B., additional, de Cima, Sara, additional, Hedrera, Segundo A., additional, Laca, Sonia I., additional, Llorente-Álvarez, Susana, additional, Pascual, Susana, additional, Cimas, Teodorna, additional, Mathur, Anthony, additional, McFarlane-Henry, Eleanor, additional, Leonard, Gerry, additional, Veerapen, Jessry, additional, Westwood, Mark, additional, Colicchia, Martina, additional, Prossora, Mary, additional, Andiapen, Mervyn, additional, Mohiddin, Saidi, additional, Lenzi, Valentina, additional, Chong, Jun, additional, Francis, Rohin, additional, Pine, Amy, additional, Jamieson-Leadbitter, Caroline, additional, Neal, Debbie, additional, Din, J., additional, McLeod, Jane, additional, Roberts, Josh, additional, Polokova, Karin, additional, Longman, Kristel, additional, Penney, Lucy, additional, Lakeman, Nicki, additional, Wells, Nicki, additional, Hopper, Oliver, additional, Coward, Paul, additional, O'Kane, Peter, additional, Harkins, Ruth, additional, Guyatt, Samantha, additional, Kennard, Sarah, additional, Orr, Sarah, additional, Horler, Stephanie, additional, Morris, Steve, additional, Walvin, Tom, additional, Snow, Tom, additional, Cunnington, Michael, additional, Burd, Amanda, additional, Gowing, Anne, additional, Krishnamurthy, Arvindra, additional, Harland, Charlotte, additional, Norfolk, Derek, additional, Johnstone, Donna, additional, Newman, Hannah, additional, Reed, Helen, additional, O'Neill, James, additional, Greenwood, John, additional, Cuxton, Josephine, additional, Corrigan, Julie, additional, Somers, Kathryn, additional, Anderson, Michelle, additional, Burtonwood, Natalie, additional, Bijsterveld, Petra, additional, Brogan, Richard, additional, Ryan, Tony, additional, Kodoth, Vivek, additional, Khan, Arif, additional, Sebastian, Deepti, additional, Gorog, Diana, additional, Boyle, Georgina, additional, Shepherd, Lucy, additional, Hamid, Mahmood, additional, Farag, Mohamed, additional, Spinthakis, Nicholas, additional, Waitrak, Paulina, additional, De Sousa, Phillipa, additional, Bhatti, Rishma, additional, Oliver, Victoria, additional, Walshe, Siobhan, additional, Odedra, Toral, additional, Gue, Ying, additional, Kanji, Rahim, additional, Ryding, Alisdair, additional, Ratcliffe, Amanda, additional, Merrick, Angela, additional, Horwood, Carol, additional, Sarti, Charlotte, additional, Maart, Clint, additional, Moore, Donna, additional, Dockerty, Francesca, additional, Baucutt, Karen, additional, Pitcher, Louise, additional, Ilsley, Mary, additional, Clarke, Millie, additional, Germon, Rachel, additional, Gomes, Sara, additional, Clare, Thomas, additional, Nair, Sunil, additional, Staines, Jocasta, additional, Nicholson, Susan, additional, Watkinson, Oliver, additional, Gallagher, Ian, additional, Nelthorpe, Faye, additional, Musselwhite, Janine, additional, Grosser, Konrad, additional, Stimson, Leah, additional, Eaton, Michelle, additional, Heppell, Richard, additional, Turney, Sharon, additional, Horner, Victoria, additional, Schumacher, Natasha, additional, Moon, Angela, additional, Mota, Paula, additional, O'Donnell, Joshua, additional, Panicker, Abeesh Sadasiva, additional, Musa, Anntoniette, additional, Tapp, Luke, additional, Krishnamoorthy, Suresh, additional, Ansell, Valerie, additional, Ali, Danish, additional, Hyndman, Samantha, additional, Banerjee, Prithwish, additional, Been, Martin, additional, Mackenzie, Ailie, additional, McGregor, Andrew, additional, Hildick-Smith, David, additional, Champney, Felicity, additional, Ingoldby, Fiona, additional, Keate, Kirstie, additional, Bennett, Lorraine, additional, Skipper, Nicola, additional, Gregory, Sally, additional, Harfield, Scott, additional, Mudd, Alexandra, additional, Wragg, Christopher, additional, Barmby, David, additional, Grech, Ever, additional, Hall, Ian, additional, Middle, Janet, additional, Barker, Joann, additional, Fofie, Joyce, additional, Gunn, Julian, additional, Housley, Kay, additional, Cockayne, Laura, additional, Weatherlley, Louise, additional, Theodorou, Nana, additional, Wheeldon, Nigel, additional, Fati, Pene, additional, Storey, Robert F., additional, Richardson, James, additional, Iqbal,, Javid, additional, Adam, Zul, additional, Brett, Sarah, additional, Agyemang, Michael, additional, Tawiah, Cecilia, additional, Hogrefe, Kai, additional, Raju, Prashanth, additional, Braybrook, Christine, additional, Gracey, Jay, additional, Waldron, Molly, additional, Holloway, Rachael, additional, Burunsuzoglu, Senem, additional, Sidgwick, Sian, additional, Hetherington, Simon, additional, Beirnes, Charmaine, additional, Fernandez, Olga, additional, Lazar, Nicoleta, additional, Knighton, Abigail, additional, Rai, Amrit, additional, Hoare, Amy, additional, Breeze, Jonathan, additional, Martin, Katherine, additional, Andrews, Michelle, additional, Patale, Sheetal, additional, Bennett, Amy, additional, Smallwood, Andrew, additional, Radford, Elizabeth, additional, Cotton, James, additional, Martins, Joe, additional, Wallace, Lauren, additional, Milgate, Sarah, additional, Munir, Shahzad, additional, Metherell, Stella, additional, Cottam, Victoria, additional, Massey, Ian, additional, Copestick, Jane, additional, Delaney, Jane, additional, Wain, Jill, additional, Sandhu, Kully, additional, Emery, Lisa, additional, Hall, Charlotte, additional, Bucciarelli-Ducci, Chiara, additional, Besana, Rissa, additional, Hussein, Jodie, additional, Bell, Sheila, additional, Gill, Abby, additional, Bales, Emily, additional, Polwarth, Gary, additional, East, Clare, additional, Smith, Ian, additional, Oliveira, Joana, additional, Victor, Saji, additional, Woods, Sarah, additional, Hoole, Stephen, additional, Ramos, Angelo, additional, Sevillano, Annaliza, additional, Nicholson, Anne, additional, Solieri, Ashley, additional, Redman, Emily, additional, Byrne, Jean, additional, Joyce, Joan, additional, Riches, Joanne, additional, Davies, John, additional, Allen, Kezia, additional, Saclot, Louie, additional, Ocampo, Madelaine, additional, Vertue, Mark, additional, Christmas, Natasha, additional, Koothoor, Raiji, additional, Gamma, Reto, additional, Alvares, Wilson, additional, Pepper, Stacey, additional, Kobson, Barbara, additional, Reeve, Christy, additional, Malik, Iqbal, additional, Chester, Emma, additional, Saunders, Heidi, additional, Mojela, Idah, additional, Smee, Joanna, additional, Davies, Justin, additional, Davies, Nina, additional, Clifford, Piers, additional, Dias, Priyanthi, additional, Kaur, Ramandeep, additional, Moreira, Silvia, additional, Ahmad, Yousif, additional, Tomlinson, Lucy, additional, Pengelley, Clare, additional, Bidle, Amanda, additional, Spence, Sharon, additional, Al-Lamee, Rasha, additional, Phuyal, Urmila, additional, Abbass, Hakam, additional, Bose, Tuhina, additional, Elliott, Rebecca, additional, Foundun, Aboo, additional, Chung, Alan, additional, Freestone, Beth, additional, Lee, Dr Kaeng, additional, Elshiekh, Dr Mohamed, additional, Pulikal, George, additional, Bhatre, Gurbir, additional, Douglas, James, additional, Kaeng, Lee, additional, Pitt, Mike, additional, Watkins, Richard, additional, Gill, Simrat, additional, Hartley, Amy, additional, Lucking, Andrew, additional, Moreby, Berni, additional, Darby, Damaris, additional, Corps, Ellie, additional, Parsons, Georgina, additional, De Mance, Gianluigi, additional, Fahrai, Gregor, additional, Turner, Jenny, additional, Langrish, Jeremy, additional, Gaughran, Lisa, additional, Wolyrum, Mathias, additional, Azkhalil, Mohammed, additional, Bates, Rachel, additional, Given, Rachel, additional, Kharbanda, Rajesh, additional, Douthwaite, Rebecca, additional, Lloyd, Steph, additional, Neubauer, Stephen, additional, Barker, Deborah, additional, Suttling, Anne, additional, Turner, Charlotte, additional, Smith, Clare, additional, Longbottom, Colin, additional, Ross, David, additional, Cunliffe, Denise, additional, Cox, Emily, additional, Whitehead, Helena, additional, Hudson, Karen, additional, Jones, Leslie, additional, Drew, 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additional, Jamal, Zahra, additional, Hetherington, Daniel, additional, and Collier, Lucy, additional

Published
2019
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97. Everolimus-Eluting Versus Biolimus-Eluting Stents With Biodegradable Polymers in Unselected Patients Undergoing Percutaneous Coronary Intervention:A Randomized Noninferiority Trial With 1-Year Follow-Up (SORT OUT VIII Trial)

Author

Maeng, Michael, Christiansen, Evald Høj, Raungaard, Bent, Kahlert, Johnny, Terkelsen, Christian Juhl, Kristensen, Steen Dalby, Carstensen, Steen, Aarøe, Jens, Jensen, Svend Eggert, Villadsen, Anton Boel, Lassen, Jens Flensted, Thim, Troels, Eftekhari, Ashkan, Veien, Karsten Tange, Hansen, Knud Nørregaard, Junker, Anders, Bøtker, Hans Erik, and Jensen, Lisette Okkels

Subjects
CLINICAL-OUTCOMES, percutaneous coronary intervention, COMPARE II, biodegradable polymer, EFFICACY, drug-eluting stent(s), everolimus, randomized clinical trial, biolimus, REGISTRY, SAFETY, COATED STENT, RESTENOSIS, THIN, SYSTEM, RANDOMIZED SORT
Abstract

OBJECTIVES: The aim of this study was to compare the thin-strut biodegradable-polymer everolimus-eluting platinum-chromium stent (EES) with the biodegradable-polymer biolimus-eluting stainless-steel stent (BES).BACKGROUND: Currently available drug-eluting coronary stents have been refined to reduce the risk for coronary events following implantation.METHODS: This randomized, multicenter, all-comers, noninferiority trial was undertaken at 3 sites in western Denmark. Patients with clinical indications for percutaneous coronary intervention were eligible for inclusion. Patients were randomly assigned (1:1) to either EES or BES. The primary endpoint, target lesion failure, was a composite of safety (cardiac death and myocardial infarction not clearly attributable to a nontarget lesion) and efficacy (target lesion revascularization) at 12 months, analyzed using intention-to-treat principles. The trial was powered to assess target lesion failure noninferiority of the EES compared with the BES with a predetermined noninferiority margin of 3%.RESULTS: A total of 1,385 patients were assigned to treatment with EES and 1,369 patients to treatment with BES. The analysis showed that 55 patients (4.0%) assigned to the EES and 60 (4.4%) assigned to the BES met the primary endpoint (absolute risk difference 0.4%; upper limit of 1-sided 95% confidence interval: 1.7%; p < 0.001).CONCLUSIONS: At 1-year follow-up, the EES was found to be noninferior to the BES with respect to target lesion failure. (Everolimus-eluting SYNERGY Stent Versus Biolimus-Eluting Biomatrix NeoFlex Stent-SORT-OUT VIII; NCT02093845).

Published
2019

98. Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction:ATLANTIC-Morphine

Author

Lapostolle, Frederic, van't Hof, Arnoud W., Hamm, Christian W., Stibbe, Olivier, Ecollan, Patrick, Collet, Jean-Philippe, Silvain, Johanne, Lassen, Jens Flensted, Heutz, Wim M. J. M., Bolognese, Leonardo, Cantor, Warren J., Cequier, Angel, Chettibi, Mohamed, Goodman, Shaun G., Hammett, Christopher, Huber, Kurt, Janzon, Magnus, Merkely, Bela, Storey, Robert F., ten Berg, Jur, Zeymer, Uwe, Licour, Muriel, Tsatsaris, Anne, Montalescot, Gilles, Bougherbal, Rachid, Bouafia, Mohamed Tahar, Nibouche, Djamaleddine, Moklati, Abdelkader, Benalia, Ahmed, Krim, Messaad, Garraby, Paul, Jayasinghe, Rohan, Rashford, Stephen, Neunteufl, Thomas, Brussee, Helmut, Alber, Hannes, Weidinger, Franz, Baubin, Michael, Sebald, Dieter, Cantor, Warren, Vijayaraghavan, Ram, Bata, Iqbal, Lavoie, Andrea, Ravkilde, Jan, Jensen, Lisette Okkels, Christensen, Alf Mol, Université Sorbonne Paris Cité (USPC), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Brigade de sapeurs pompiers de Paris (BSPP), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Aarhus University Hospital, University of Toronto, University of Barcelona, Centre Hospitalo-Universitaire de Blida (CHU Blida), St. Michael's Hospital, Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Linköping University (LIU), Semmelweis University of Medicine [Budapest], University of Sheffield [Sheffield], St. Antonius Hospital [Nieuwegein], AstraZeneca, RS: Carim - H01 Clinical atrial fibrillation, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), and RS: CARIM - R2.01 - Clinical atrial fibrillation

Subjects
Male, Ticagrelor, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Chest pain, DOUBLE-BLIND, 0302 clinical medicine, PRASUGREL, REPERFUSION, Pharmacology (medical), 030212 general & internal medicine, Myocardial infarction, Stroke, OUTCOMES, Morphine, General Medicine, Thrombolysis, ASSOCIATION, Middle Aged, 3. Good health, Analgesics, Opioid, INSIGHTS, Treatment Outcome, surgical procedures, operative, Cardiology, Female, TRIAL, medicine.symptom, Cardiology and Cardiovascular Medicine, TIMI, medicine.drug, Adult, medicine.medical_specialty, Pain, Platelet Glycoprotein GPIIb-IIIa Complex, Revascularization, 03 medical and health sciences, Percutaneous Coronary Intervention, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, cardiovascular diseases, Aged, Retrospective Studies, business.industry, Percutaneous coronary intervention, medicine.disease, ST Elevation Myocardial Infarction, business, Platelet Aggregation Inhibitors
Abstract

Background: Morphine adversely impacts the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly associated with differing patient characteristics. This retrospective analysis investigated whether interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study was associated with differences in patient characteristics and management. Methods: ATLANTIC was an international, multicenter, randomized study of treatment in the acute ambulance/hospital setting where STEMI patients received ticagrelor 180 mg ± morphine. Patient characteristics, cardiovascular history, risk factors, management, and outcomes were recorded. Results: Opioids (97.6% morphine) were used in 921 out of 1862 patients (49.5%). There were no significant differences in age, sex or cardiovascular history, but more morphine-treated patients had anterior myocardial infarction and left-main disease. Time from chest pain to electrocardiogram and ticagrelor loading was shorter with morphine (both p = 0.01) but not total ischemic time. Morphine-treated patients more frequently received glycoprotein IIb/IIIa inhibitors (p = 0.002), thromboaspiration and stent implantation (both p < 0.001). No significant difference between the two groups was found regarding pre-PCI ≥ 70% ST-segment elevation resolution, death, myocardial infarction, stroke, urgent revascularization and definitive acute stent thrombosis. More morphine-treated patients had an absence of pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow (85.8% vs. 79.7%; p = 0.001) and more had TIMI major bleeding (1.1% vs. 0.1%; p = 0.02). Conclusions: Morphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain. Trial Registration: clinicaltrials.gov identifier: NCT01347580.

Published
2019

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