259 results on '"Larroque, B."'
Search Results
52. Previous Induced Abortions and the Risk of Very Preterm Delivery: Results of the EPIPHAGE Study
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Moreau, Caroline, primary, Kaminski, Monique, additional, Ancel, Piere Yves, additional, Bouyer, Jean, additional, Escande, Beno??t, additional, Thiriez, G??rard, additional, Boulot, Pierre, additional, Fresson, Jeanne, additional, Arnaud, Catherine, additional, Subtil, Damien, additional, Marpeau, Loic, additional, Roz??, Jean-Christophe, additional, Maillard, Fran??oise, additional, and Larroque, B??arice, additional
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- 2005
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53. 88 Prolonged Sedation / Analgesia ( S/A ) and 4-Year Outcome in Preterm Newborns: Results from the Epipage Cohort.
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Denizot, S, primary, Rozé, J C, additional, Ancel, P Y, additional, Larroque, B, additional, Carbajal, R, additional, Kaminski, M, additional, and Bréart, G, additional
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- 2005
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54. 218 Cognitive Status of 5 Years Old Very Preterm Children : The Epipage Study
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Larroque, B, primary, Marchand, L, additional, and Kaminski, M, additional
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- 2005
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55. 70 Risk Factors of Extrauterine Growth Restriction of Very Preterm Newborns. Results from The Epipage Nord Pas De Calais Cohort
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Desnoulez, L, primary, Truffert, P, additional, Putet, G, additional, Kaminski, M, additional, and Larroque, B, additional
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- 2004
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56. Moderate prenatal alcohol exposure and psychomotor development at preschool age.
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Larroque, B, primary, Kaminski, M, additional, Dehaene, P, additional, Subtil, D, additional, Delfosse, M J, additional, and Querleu, D, additional
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- 1995
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57. Clinical outcome after a totally implantable venous access port-related infection in cancer patients: a prospective study and review of the literature.
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Lebeaux D, Larroque B, Gellen-Dautremer J, Leflon-Guibout V, Dreyer C, Bialek S, Froissart A, Hentic O, Tessier C, Ruimy R, Pelletier AL, Crestani B, Fournier M, Papo T, Barry B, Zarrouk V, Fantin B, Lebeaux, David, Larroque, Béatrice, and Gellen-Dautremer, Justine
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- 2012
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58. Behavioural outcome at 3 years of age in very preterm infants: the Epipage cohort study
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Larroque, B. and Delobel, M.
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France -- Research ,Infants (Premature) -- Health aspects ,Infants (Premature) -- Research ,Health ,Social sciences - Published
- 2004
59. Delayed development at 1 year in very preterm infants: the epipage cohort study
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Larroque, B., Burguet, A., and Marret, S.
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France -- Research ,Infants (Premature) -- Research ,Infants (Premature) -- Health aspects ,Child development -- Research ,Health ,Social sciences - Published
- 2004
60. Space Time Clustering of Births in SIDS
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LARROQUE, B, primary and BOUVIER-COLLE, M H, additional
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- 1993
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61. Letter
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Larroque B and Kaminski M
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medicine.medical_specialty ,Epidemiology ,business.industry ,Obstetrics ,Birth weight ,Medicine ,business ,Alcohol consumption during pregnancy - Published
- 1996
62. Folate status during pregnancy: relationship with alcohol consumption, other maternal risk factors and pregnancy outcome
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Larroque, B., primary, Kaminski, M., additional, Lelong, N., additional, d'Herbomez, M., additional, Dehaene, P., additional, Querleu, D., additional, and Crépin, G., additional
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- 1992
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63. Chapter 2 Alcohol and the Fetus
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Larroque, B, primary
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- 1992
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64. Prolonged sedation and/or analgesia and 5-year neurodevelopment outcome in very preterm infants: results from the EPIPAGE cohort.
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Rozé JC, Denizot S, Carbajal R, Ancel PY, Kaminski M, Arnaud C, Truffert P, Marret S, Matis J, Thiriez G, Cambonie G, André M, Larroque B, and Bréart G
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- 2008
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65. Towards a Complete Design of Linear Functional Observers.
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Larroque, B., Noureddine, F., and Rotella, F.
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- 2008
66. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study.
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Larroque B, Ancel P, Marret S, Marchand L, André M, Arnaud C, Pierrat V, Rozé J, Messer J, Thiriez G, Burguet A, Picaud J, Bréart G, Kaminski M, and EPIPAGE Study Group
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- 2008
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67. Prevalence and associated factors of minor neuromotor dysfunctions at age 5 years in prematurely born children: the EPIPAGE Study.
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Arnaud C, Daubisse-Marliac L, White-Koning M, Pierrat V, Larroque B, Grandjean H, Alberge C, Marret S, Burguet A, Ancel PY, Supernant K, and Kaminski M
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- 2007
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68. Neonatal and 5-year outcomes after birth at 30-34 weeks of gestation.
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Marret S, Ancel P, Marpeau L, Marchand L, Pierrat V, Larroque B, Foix-L'Hélias L, Thiriez G, Fresson J, Alberge C, Rozé J, Matis J, Bréart G, Kaminski M, and Epipage Study Group
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- 2007
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69. Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia? Results of the EPIPAGE cohort study.
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Ancel P, Marret S, Larroque B, Arnaud C, Zupan-Simunek V, Voyer M, Rozé J, Matis J, Burguet A, Ledésert B, André M, Pierrat V, Kaminski M, and Epipage Study Group
- Abstract
OBJECTIVE: The purpose of this study was to examine the relationships between different causes of preterm delivery (eg, maternal hypertension, small-for-gestational age [SGA], other) and cerebral damage (eg, cystic periventricular leukomalacia [c-PVL], grade III intraventricular hemorrhage [IVH], and intra-parenchymal hemorrhage [IPH]). STUDY DESIGN: This study included 1902 very preterm singletons who were transferred to neonatal intensive care units in 9 French regions. We used logistic regression models to compare the risk of cerebral injury associated with maternal hypertension, SGA, and all other causes of preterm delivery. RESULTS: We found that the risk of c-PVL and grade III IVH was higher in infants born after preterm premature rupture of membranes (PPROM) with short latency or idiopathic preterm labor than in infants born to hypertensive mothers. We show that SGA and antepartum maternal hemorrhage significantly increase the risk of IPH. CONCLUSION: Our results show that infants born to hypertensive mothers have a lower risk of cerebral injuries than infants born following idiopathic preterm labor and PPROM because they are less exposed to prenatal infection. [ABSTRACT FROM AUTHOR]
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- 2005
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70. Prenatal risk factors for cerebral palsy in very preterm singletons and twins.
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Livinec F, Ancel P, Marret S, Arnaud C, Fresson J, Pierrat V, Rozé J, Escande B, Thiriez G, Larroque B, Kaminski M, and Epipage Group
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- 2005
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71. The complex relationship between smoking in pregnancy and very preterm delivery. Results of the Epipage study.
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Burguet A, Kaminski M, Abraham-Lerat L, Schaal J, Cambonie G, Fresson J, Grandjean H, Truffert P, Marpeau L, Voyer M, Rozé J, Treisser A, Larroque B, EPIPAGE Study Group, Burguet, Antoine, Kaminski, Monique, Abraham-Lerat, Laurence, Schaal, Jean-Patrick, Cambonie, Gilles, and Fresson, Jeanne
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Objective: To assess the relationship between cigarette smoking during pregnancy and very preterm births, according to the main mechanisms of preterm birth.Design: Case-control study (the French Epipage study).Setting: Regionally defined population of births in France.Population: Eight hundred and sixty-four very preterm live-born singletons (between 27 and 32 completed weeks of gestation) and 567 unmatched full-term controls.Methods: Data from the French Epipage study were analysed using a polytomous logistic regression model to control for social and demographic characteristics, pre-pregnancy body mass index and obstetric history. The main mechanisms of preterm delivery were classified as gestational hypertension, antepartum haemorrhage, premature rupture of membranes, spontaneous preterm labour and other miscellaneous mechanisms.Main Outcome Measures: Odds ratios for very preterm birth for low to moderate (1-9 cigarettes/day) and heavy (>/=10 cigarettes/day) maternal smoking in pregnancy, estimated according to the main mechanisms leading to preterm birth.Results: Smokers were more likely to give birth to very preterm infants than non-smokers [adjusted odds ratio (aOR) 1.7, 95% confidence interval (CI) 1.3-2.2]. Heavy smoking significantly reduced the risk of very preterm birth due to gestational hypertension (aOR 0.5, 95% CI 0.3-1.0), whereas both low to moderate and heavy smoking increased the risk of very preterm birth due to all other mechanisms (aOR between 1.6 and 2.8).Conclusion: These data from the Epipage study show that maternal smoking during pregnancy is a risk factor for very preterm birth. The impact of maternal smoking on very preterm birth appears to be complex: it lowers the risk of very preterm birth due to gestational hypertension, but increases the risk of very preterm birth due to other mechanisms. These findings might explain why maternal smoking is more closely related to preterm birth among multiparous women than among nulliparous women. [ABSTRACT FROM AUTHOR]- Published
- 2004
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72. Influence of severity of congenital hypothyroidism and adequacy of treatment on school achievement in young adolescents: a population-based cohort study.
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Léger, J, Larroque, B, Norton, J, Léger, J, and Association Française pour le Dépistage et la Prévetion des Handicaps de l'Enfant
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CONGENITAL hypothyroidism , *PERFORMANCE , *ADOLESCENCE , *AGE distribution , *DEVELOPMENTAL disabilities , *HYPOTHYROIDISM , *NEWBORN screening , *LONGITUDINAL method , *MULTIVARIATE analysis , *PATIENT compliance , *THYROXINE , *ACHIEVEMENT , *SOCIOECONOMIC factors , *RELATIVE medical risk , *SEVERITY of illness index , *CASE-control method - Abstract
Aim: To evaluate whether precociously treated subjects with congenital hypothyroidism (CH) are at risk of poor school performance in early adolescence, and to investigate which factors affect their school achievement.Methods: All children treated early for congenital hypothyroidism and born in France during the first 7 y (1979-1985) of the national screening program for congenital hypothyroidism were selected for the study. School performance during childhood, assessed according to age at entry into the first grade of secondary school, was evaluated as normal (usually 11 y of age) vs late entry (> or = 12 y). The national register of children with congenital hypothyroidism enabled a comparison to be made with data from the national population for the same school years.Results: School achievement was similar among the 682 patients with CH and in the national population. After an adjustment for the sex and socioprofessional category of the parents, the severity of CH as assessed by the type (athyreosis. the most severe vs other types), the initial low serum T4 levels (< or = 53 nmol/L vs >53 nmol/L), and the profound bone maturation delay (absence vs presence of the two knee epiphyseal ossification centres at diagnosis), initially low L-thyroxine dosage (below vs > or = 7 microg/kg/day), the absence of near normalization of thyroid hormone levels after 15 d of treatment and poor adequacy of treatment throughout childhood were associated with an increased risk of school delay. School achievement was unaffected by the age at start of treatment (mean age = 22.8 +/- 6.8 d). In a multivariate logistic regression analysis, recurrent episodes of insufficiently suppressed TSH levels (> or = 15 mUi/L at least four times during follow-up from the age of 6 mo onwards) were the most important variable associated with school delay.Conclusion: Careful follow-up of the adequacy of treatment is required throughout childhood, to reduce the risk of school delay. [ABSTRACT FROM AUTHOR]- Published
- 2001
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73. Prenatal alcohol exposure and signs of minor neurological dysfunction at preschool age.
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Larroque, Béatrice, Kaminski, Monique, Dehaene, Phillipe, Subtil, Damien, Querleu, Denis, Larroque, B, Kaminski, M, Dehaene, P, Subtil, D, and Querleu, D
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- 2000
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74. P120 Étude de la composition et de l’activité du microbiote chez des patients atteints de syndrome de grêle court : dosage fécal de D-lactate outil prédictif d’acidose métabolique ?
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Mayeur, C., Joly, F., Ghandour, F., Kapel, N., Larroque, B., and Thomas, M.
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- 2011
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75. O11 Augmentation de la sécrétion à jeun et postprandiale des entéropeptides GLP-2, GLP-1 et PYY chez des patients avec syndrome de grêle court avec colon en continuité comparés à des sujets contrôles
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Gillard, L., Benkouhi, A., Gandhour, F., Larroque, B., Rousset, M., Lacorte, J.-M., Le Beyec, J., and Joly, F.
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- 2011
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76. Participation in a mail survey: role of repeated mailings and characteristics of nonrespondents among recent mothers.
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Larroque, Kaminski, Bouvier-Colle, Hollebecque, Larroque, Béatrice, Larroque, B, Kaminski, M, Bouvier-Colle, M H, and Hollebecque, V
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HEALTH surveys ,MAIL surveys ,MOTHERS ,MATERNAL & infant welfare - Abstract
This study analysed the characteristics of respondent and nonrespondent mothers at each stage of a survey procedure, from a initial questionnaire to a reminder letter and two repeated mailings. Of 938 mothers of liveborn children who, while maternity inpatients, received a questionnaire and information about a mail survey to follow 2 months later, 828 completed and returned the initial questionnaire, 708 agreed to participate in the mail survey and were sent the mail questionnaire, and 612 finally completed and returned the questionnaire at 2 months. There were differences between respondents and non-respondents for socio-demographic factors at each stage of the process. The final response rate to the mail questionnaire was higher among mothers who were younger, were breast feeding, and had more education, an occupation and fewer children. The characteristics of late respondents were intermediate between those of early to middle respondents and nonrespondents for age, educational level, breast feeding and occupation. Maternal and infant health varied only slightly according to response status. Repeated mailings increased response and diminished selection. A mail questionnaire after contact in a maternity ward is a cost-effective means of gathering data about a large sample of recent mothers and their children. [ABSTRACT FROM AUTHOR]
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- 1999
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77. Alcohol and the fetus.
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Larroque, B
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FETAL alcohol syndrome ,ALCOHOLISM ,LOW birth weight ,ALCOHOL drinking ,EVALUATION of medical care ,PREGNANCY ,PREGNANCY complications - Abstract
The teratogenic effects of alcohol have been recognized in the fetal alcohol syndrome. The syndrome is associated with very high levels of maternal consumption. Studies of the relation between much lower levels of consumption and pregnancy outcome seem to indicate consistently lower birthweight among children born to mothers drinking more than 140 g absolute alcohol per week, or about two drinks a day. [ABSTRACT FROM AUTHOR]
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- 1992
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78. Factors correlated with homosexually acquired human immunodeficiency virus infection in the era of "safer sex". Was the prevention message clear and well understood? Alain Brugeat Physician Group.
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Messiah, Antoine, Bucquet, Denis, Mettetal, Jean-Florian, Larroque, Beatrice, Rouzioux, Christine, Messiah, A, Bucquet, D, Mettetal, J F, Larroque, B, and Rouzioux, C
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- 1993
79. Effects of birth weight of alcohol and caffeine consumption during pregnancy.
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Larroque, B, Kaminski, M, Lelong, N, Subtil, D, and Dehaene, P
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The aim of this study was to investigate the effect of alcohol and caffeine consumption on birth weight and the possible interaction of these substances with smoking. The sample included 628 women who were interviewed at their first visit to the maternity hospital of Roubaix, France, in 1985-1986. A significant reduction in birth weight was found to be associated with an average daily alcohol consumption of three drinks or more after gestational age, infant sex, maternal age, parity, weight, and height, and cigarette smoking had been controlled for. There was no interaction between smoking and alcohol consumption on birth weight, but a significant relation between alcohol consumption and birth weight was observed among nonsmokers as well as heavy smokers. The relation observed between caffeine and birth weight disappeared after adjustment for smoking. Our results indicate that alcohol reduces birth weight, but do not support the hypothesis of an interaction between smoking and alcohol consumption.
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- 1993
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80. BEHAVIOURAL OUTCOME AT 3 YEARS OF AGE IN VERY PRETERM INFANTS: THE EPI PAGE COHORT STUDY.
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Larroque, B. and Delobel, M.
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CHILD psychology , *PREMATURE infants , *INTERPERSONAL relations , *SOCIAL status , *QUESTIONNAIRES , *COHORT analysis , *AGE - Abstract
The article reports a study to determine behavioural outcome at 3 years age in very premature infants in a regionally defined, prospective cohort study. Results of the study revealed that on the behaviour questionnaire, the very premature infants showed significantly higher difficulties than term children. Boys had higher total difficulty and hyperactivity scores. A lower socioeconomic status was related to a higher frequency of behavioural problems, which was significant for total difficulty score, conduct problems score and pro social behaviour score. Researchers concluded that the prevalence of behavioural problems assessed by parents at 3 years of very premature infants was higher than in term infants.
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- 2004
81. COGNITIVE STATUS OF 5 YEARS OLD VERY PRETERM CHILDREN THE EPIPAGE STUDY
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LARROQUE, B, MARCHAND, L, and KAMINSKI, M
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- 2005
82. PROLONGED SEDATION / ANALGESIA ( S/A ) AND 4-YEAR OUTCOME IN PRETERM NEWBORNS RESULTS FROM THE EPIPAGE COHORT.
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DENIZOT, S, ROZÉ, J C, ANCEL, P Y, LARROQUE, B, CARBAJAL, R, KAMINSKI, M, and BRÉART, G
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- 2005
83. Postpartum psychological distress associated with anal incontinence in the EDEN mother–child cohort: Postpartum psychological distress and anal incontinence
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Marie Aline Charles, Jonathan Bernard, Regis HANKARD, Blandine De Lauzon-Guillain, Xavier FRITEL, Marie-Josephe Saurel-Cubizolles, Johanna Lepeule, Barbara Heude, Patricia Dargent-Molina, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), We acknowledge all funding sources for the EDEN study: FRM (Fondation pour la Recherche Médicale), INSERM, Ministère de la Recherche, Université Paris Sud (XI), ANR (Agence Nationale de la Recherche), IRESP (Institut de Recherche en Santé Publique), AFSSET (Agence Française pour la Surveillance et la Sécurité de l’Environnement et du Travail), Santé Publique France (Institut National Pour l’Education et la Santé, Institut National de Veille Sanitaire), DGS (Direction Générale de la Santé), ALFEDIAM (Association de Langue Française pour l'Etude du Diabète et du Métabolisme), MGEN (Mutuelle générale de l’Education Nationale), Nestlé., EDEN Mother-Child Cohort Study Group : Collaborators (27) Annesi-Maesano I, Bernard JY, Botton J, Charles MA, Dargent-Molina P, de Lauzon-Guillain B, Ducimetière P, de Agostini M, Foliguet B, Forhan A, Fritel X, Germa A, Goua V, Hankard R, Heude B, Kaminski M, Larroque B, Lelong N, Lepeule J, Magnin G, Marchand L, Nabet C, Pierre F, Slama R, Saurel-Cubizolles MJ, Schweitzer M, Thiebaugeorges O., Service de gynécologie et obstétrique [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), and EDEN Mother-Child Cohort Study Group : Annesi-Maesano I, Bernard JY, Botton J, Charles MA, Dargent-Molina P, de Lauzon-Guillain B, Ducimetière P, de Agostini M, Foliguet B, Forhan A, Fritel X, Germa A, Goua V, Hankard R, Heude B, Kaminski M, Larroque B, Lelong N, Lepeule J, Magnin G, Marchand L, Nabet C, Pierre F, Slama R, Saurel-Cubizolles MJ, Schweitzer M, Thiebaugeorges O.
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Adult ,Postpartum depression ,medicine.medical_specialty ,Population ,Breastfeeding ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Psychological Distress ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,cohort study ,Flatulence ,Humans ,postpartum ,education ,Depression (differential diagnoses) ,education.field_of_study ,Pregnancy ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,anal incontinence ,Obstetrics and Gynecology ,Puerperal Disorders ,medicine.disease ,Mental health ,Antidepressive Agents ,3. Good health ,Breast Feeding ,Multivariate Analysis ,Cohort ,depression ,Female ,France ,business ,Fecal Incontinence ,Cohort study - Abstract
Objective To estimate the prevalence of flatus-only and faecal incontinence, to describe their risk factors and to analyse the association between anal incontinence and psychological distress over the first year postpartum. Design Cohort study from pregnancy to 12 months postpartum. Setting Two university hospital maternity wards in France. Population A total of 2002 pregnant women were recruited between 2003 and 2006. Data on anal incontinence were available for the 1632 women who comprise the sample for analysis. Methods Women were enrolled during pregnancy. A postal questionnaire was sent at 4 and 12 months postpartum. Main outcome measures Anal (flatus-only and faecal) incontinence was assessed at 4 months postpartum. Mental health was assessed at 4 and 12 months postpartum by the Edinburgh Postpartum Depression Scale (EPDS) and use of antidepressant drugs as well as by self-rated mental health. Results At 4 months postpartum, the prevalence for flatus-only incontinence was 14.4% and for faecal incontinence 1.7%; multivariate analysis, restricted to women reporting no anal incontinence before the index pregnancy, showed that continuing breastfeeding at 4 months was related to a higher risk of de novo postpartum anal incontinence (OR = 2.23). Women who reported anal incontinence at 4 months were more frequently depressed (EPDS ≥10 or antidepressant use) at 12 months postpartum: 36.0% of those with faecal incontinence were depressed, 23.3% of those with flatus-only incontinence and only 14.8% of the continent women. Conclusion Postnatal faecal incontinence was rare but associated with poorer maternal mental health. Postnatal screening should be encouraged, and psychological support offered. Tweetable abstract Postnatal faecal incontinence was associated with depression; postnatal screening should be encouraged and psychological support offered.
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- 2019
84. Postpartum psychological distress associated with anal incontinence in the EDEN mother–child cohort
- Author
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Fritel, Xavier, Gachon, Bertrand, Mj, Saurel-Cubizolles, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), We acknowledge all funding sources for the EDEN study: FRM (Fondation pour la Recherche Médicale), INSERM, Ministère de la Recherche, Université Paris Sud (XI), ANR (Agence Nationale de la Recherche), IRESP (Institut de Recherche en Santé Publique), AFSSET (Agence Française pour la Surveillance et la Sécurité de l’Environnement et du Travail), Santé Publique France (Institut National Pour l’Education et la Santé, Institut National de Veille Sanitaire), DGS (Direction Générale de la Santé), ALFEDIAM (Association de Langue Française pour l'Etude du Diabète et du Métabolisme), MGEN (Mutuelle générale de l’Education Nationale), Nestlé., EDEN Mother-Child Cohort Study Group : Collaborators (27) Annesi-Maesano I, Bernard JY, Botton J, Charles MA, Dargent-Molina P, de Lauzon-Guillain B, Ducimetière P, de Agostini M, Foliguet B, Forhan A, Fritel X, Germa A, Goua V, Hankard R, Heude B, Kaminski M, Larroque B, Lelong N, Lepeule J, Magnin G, Marchand L, Nabet C, Pierre F, Slama R, Saurel-Cubizolles MJ, Schweitzer M, Thiebaugeorges O., and Fritel, Xavier
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[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,anal incontinence ,depression ,cohort study ,postpartum ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics - Abstract
International audience; OBJECTIVE:To estimate the prevalence of flatus-only and faecal incontinence, to describe their risk factors, and to analyse the association between anal incontinence and psychological distress over the first 1 year postpartum.DESIGN:Cohort study from pregnancy to 12 months postpartum SETTING: Two university hospital maternity wards in France POPULATION: 2002 pregnant women were recruited between 2003 and 2006. Data on anal incontinence was available for the 1632 women who comprise the sample for analysis.METHODS:Women were enrolled during pregnancy. A postal questionnaire was sent at 4 and 12 months postpartum.MAIN OUTCOME MEASURES:Anal (flatus-only and faecal) incontinence was assessed at 4 months postpartum. Mental health was assessed at 4 and 12 months postpartum by the Edinburgh Postpartum Depression Scale (EPDS) and use of antidepressant drugs as well as by self-rated mental health.RESULTS:At 4 months postpartum, the prevalence for flatus-only incontinence was 14.4%and for faecal incontinence 1.7%; multivariate analysis, restricted to women reporting no anal incontinence before the index pregnancy, showed that continuing breastfeeding at 4 months was related to a higher risk of de novo postpartum anal incontinence (OR=2.23). Women who reported anal incontinence at 4 months were more frequently depressed (EPDS ≥ 10 or antidepressant use) at 12 months postpartum: 36.0% of those with faecal incontinence were depressed, 23.3% of those with flatus-only incontinence, and only 14.8% of the continent women.CONCLUSION:Postnatal faecal incontinence was rare but associated with poorer maternal mental health. Postnatal screening should be encouraged, and psychological support offered.
- Published
- 2019
85. Neonatal factors associated with alteration of palatal morphology in very preterm children: The EPIPAGE cohort study.
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Germa A, Marret S, Thiriez G, Rousseau S, Hascoët JM, Paulsson-Björnsson L, Söderfeldt B, Ancel PY, Larroque B, Kaminski M, and Nabet C
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- 2012
86. Maternal depression, socioeconomic position, and temperament in early childhood: the EDEN Mother-Child Cohort.
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Melchior M, Chastang JF, de Lauzon B, Galéra C, Saurel-Cubizolles MJ, Larroque B, and EDEN Mother-Child Cohort Study Group
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- 2012
87. Early determinants of food liking among 5y-old children: a longitudinal study from the EDEN mother-child cohort
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Wen Lun Yuan, Claire Chabanet, Natalie Rigal, Blandine de Lauzon-Guillain, Marie-Aline Charles, Sandrine Monnery-Patris, A. Forhan, BMC, BMC, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Université Paris Nanterre (UPN), Clinique, Psychanalyse, Développement (CliPsyD), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Fondation pour la Recherche Medicale (FRM), French Ministry of Research: Federative Research Institutes and Cohort Program, INSERM Human Nutrition National Research Program, Diabetes, the EDEN mother-child cohort Study Group, Annesi-Maesano I, Bernard JY, Botton J, Charles MA, Dargent-Molina P, de Lauzon-Guillain B, Ducimetière P, de Agostini M, Foliguet B, Forhan A, Fritel X, Germa A, Goua V, Hankard R, Heude B, Kaminski M, Larroque B, Lelong N, Lepeule J, Magnin G, Marchand L, Nabet C, Pierre F, Slama R, Saurel-Cubizolles MJ, Schweitzer M, Thiebaugeorges O., Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Université Paris Nanterre ( UPN ), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Descartes - Paris 5 ( UPD5 ), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), and Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)
- Subjects
Male ,0301 basic medicine ,Longitudinal study ,[SDV]Life Sciences [q-bio] ,Breastfeeding ,Medicine (miscellaneous) ,Food liking ,Choice Behavior ,Food group ,Eating ,Pregnancy ,Surveys and Questionnaires ,Longitudinal Studies ,Children ,Determinants ,2. Zero hunger ,Meal ,Nutrition and Dietetics ,Parenting ,Neophobia ,digestive, oral, and skin physiology ,Mother-Child Relations ,[SDV] Life Sciences [q-bio] ,Breast Feeding ,Phobic Disorders ,Child, Preschool ,Female ,Psychology ,Social psychology ,Personality ,Adult ,Mothers ,Physical Therapy, Sports Therapy and Rehabilitation ,Phobic disorder ,Food Preferences ,03 medical and health sciences ,Food neophobia ,Environmental health ,medicine ,Animals ,Humans ,030109 nutrition & dietetics ,[ SDV ] Life Sciences [q-bio] ,Research ,Body Weight ,Infant, Newborn ,children ,food liking ,determinants ,food neophobia ,longitudinal ,Infant ,Feeding Behavior ,medicine.disease ,Diet ,Longitudinal ,Breast feeding - Abstract
Background Identifying the determinants of child’s liking for different foods may help to prevent future choices of unhealthy food. Objective To study early-life food-related characteristics associated with child’s liking for different foods at 5y with a longitudinal study. Design 1142 5y- old children completed a liking test for “fruit and vegetables”, “meat, fish and eggs”, desserts and cheese. Data related to maternal food intake before pregnancy, infant feeding during the first year of life, maternal feeding practices at 2y, child’s food intake at 3y, and child’s food neophobia from 1 to 4y were collected prospectively from the mother. The associations between these factors and child‘s liking for each category of foods were analyzed using structural equation modelling. Results High food neophobia at 4 y was related to lower child’s liking for all food groups. Maternal feeding practices at 2y were associated with liking for dessert: negatively for the practices allowing child to control his/her own food intake, positively for restriction of child’s food intake for weight reasons. Moreover, child’s food intake at 3y was positively associated with child’s liking for “fruit and vegetables” as well as for cheese. Finally, adherence to the infant feeding pattern “long breastfeeding, later introduction of main meal components and use of home-made products” was positively associated with child’s liking for meat/fish/eggs. Conclusions For all food groups, food neophobia was a common determinant of child’s liking for food at 5y, whereas other factors were associated with food liking for specific food groups. Electronic supplementary material The online version of this article (doi:10.1186/s12966-016-0342-5) contains supplementary material, which is available to authorized users.
- Published
- 2016
88. Observational study of natural history of small sporadic nonfunctioning pancreatic neuroendocrine tumors
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Sébastien Gaujoux, Philippe Ruszniewski, Stefano Partelli, Domenico Tamburrino, Mirko D'Onofrio, Alain Sauvanet, Massimo Falconi, Béatrice Larroque, Frédérique Maire, Gaujoux, S, Maire, F, D'Onofrio, M, Larroque, B, Tamburrino, D, Sauvanet, A, Falconi, Massimo, Ruszniewski, P., and Partelli, Stefano
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,asymptomatic sporadic NF-PNETs ,Context (language use) ,Neuroendocrine tumors ,Biochemistry ,Asymptomatic ,Risk Assessment ,Lesion ,Tertiary Care Centers ,Endocrinology ,Imaging, Three-Dimensional ,pancreatic neuroendocrine tumors (NF-PNETs) ,Internal medicine ,medicine ,Medical imaging ,Humans ,Radionuclide Imaging ,Watchful Waiting ,Pancreas ,Aged ,Neoplasm Staging ,Retrospective Studies ,business.industry ,Biochemistry (medical) ,Middle Aged ,medicine.disease ,Prognosis ,Tumor Burden ,Natural history ,Pancreatic Neoplasms ,Neuroendocrine Tumors ,Serial imaging ,Positron-Emission Tomography ,Observational study ,Female ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Asymptomatic sporadic nonfunctioning, well-differentiated pancreatic neuroendocrine tumors (NF-PNETs) are increasingly diagnosed, and their management is controversial because of their overall good but heterogeneous prognosis.The objective of the study was to assess the natural history of asymptomatic sporadic NF-PNETs smaller than 2 cm in size and the risk-benefit balance of nonoperative management.From January 2000 to June 2011, 46 patients with proven asymptomatic sporadic NF-PNETs smaller than 2 cm in size were followed up for at least 18 months with serial imaging in tertiary referral centers.Patients were mainly female (65%), with a median age of 60 years. Tumors were mainly located in the pancreatic head (52%), with a median lesion size of 13 mm (range 9-15). After a median follow-up of 34 months (range 24-52) and an average of four (range 3-6) serial imaging sessions, distant or nodal metastases appeared on the imaging in none of the patients. In six patients (13%), a 20% or greater increase in size was observed. Overall median tumor growth was 0.12 mm per year, and neither patients nor tumor characteristics were found to be significant predictors of tumor growth. Overall, eight patients (17%) underwent surgery after a median time from initial evaluation of 41 months (range 27-58); all resected lesions were European Neuroendocrine Tumor Society T stage 1 (n = 7) or 2 (n = 1), grade 1, node negative, with neither vascular nor peripancreatic fat invasion.In selected patients, nonoperative management of asymptomatic sporadic NF-PNETs smaller than 2 cm in size is safe. Larger and prospective multicentric studies with long-term follow-up are now needed to validate this wait-and-see policy.
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- 2013
89. Determinants of neonatal weight loss in term-infants: specific association with pre-pregnancy maternal body mass index and infant feeding mode
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Regnault, Nolwenn, Botton, Jérémie, Blanc, Laurence, Hankard, Régis, Forhan, Anne, Goua, Valérie, Thiebaugeorges, Olivier, Kaminski, Monique, Heude, Barbara, Charles, Marie-Aline, Renseigné, Non, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pediatrie Multidisciplinaire - Nutrition de l'Enfant, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Service de gynécologie et obstétrique [Poitiers], Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants (UMR_S 953), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Sud - Paris 11 (UP11), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Regnault N, Botton J, Marchand L, Nabet C, Blanc L, Annesi-Maesano I, Slama R, Magnin G, Schweitzer M, Foliguet B, Job-Spira N., Hankard R, EDEN mother-child cohort study groupCharles MA, Forhan A, Goua V, Thiebaugeorges O, Kaminski M, Heude B, Charles MA, de Agostini M, Ducimetière P, Saurel-Cubizolles MJ, Dargent P, Fritel X, Larroque B, Lelong N, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Poitiers-Centre hospitalier universitaire de Poitiers ( CHU Poitiers ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), Université de Poitiers-Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants ( UMR_S 953 ), Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Male ,Pediatrics ,MESH: Infant Formula ,MESH: Infant Nutritional Physiological Phenomena ,MESH: Parenting ,MESH : Infant Nutritional Physiological Phenomena ,Body Mass Index ,0302 clinical medicine ,MESH: Pregnancy ,Pregnancy ,Weight loss ,MESH: Gestational Age ,Birth Weight ,Medicine ,MESH: Obesity ,MESH : Female ,Infant Nutritional Physiological Phenomena ,2. Zero hunger ,MESH : Parenting ,030219 obstetrics & reproductive medicine ,Parenting ,Obstetrics ,MESH: Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,General Medicine ,MESH : Adult ,Infant Formula ,3. Good health ,Gestational diabetes ,Breast Feeding ,MESH: Young Adult ,MESH: Breast Feeding ,Female ,MESH : Delivery, Obstetric ,MESH : Obesity ,Underweight ,medicine.symptom ,Adult ,medicine.medical_specialty ,Birth weight ,MESH : Male ,MESH : Young Adult ,Gestational Age ,MESH : Infant, Newborn ,MESH: Body Mass Index ,Young Adult ,03 medical and health sciences ,MESH: Weight Loss ,030225 pediatrics ,Weight Loss ,Humans ,Obesity ,MESH: Birth Weight ,MESH: Humans ,business.industry ,MESH : Humans ,Infant, Newborn ,MESH : Birth Weight ,MESH: Adult ,Delivery, Obstetric ,medicine.disease ,MESH: Male ,MESH : Pregnancy ,MESH : Body Mass Index ,Pediatrics, Perinatology and Child Health ,MESH : Breast Feeding ,MESH : Infant Formula ,MESH: Delivery, Obstetric ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH : Weight Loss ,business ,Body mass index ,Weight gain ,MESH: Female ,MESH : Gestational Age - Abstract
International audience; OBJECTIVE: We aimed to study the determinants of neonatal weight loss measured on the third day of life in term-infants. DESIGN: The EDEN mother-child cohort is a prospective study that recruited 2002 pregnant women before 24 weeks of gestation in two French university hospitals. Neonates were weighed every day until discharge that occurred on average 4.5 days after birth. Altogether, 1557 healthy term neonates with data on weight at day 3 and feeding mode available were included. The outcome variable was weight loss at day 3 (D3WL), expressed as a percentage of birth weight lost in the first 3 days of life. Our main explanatory variables were maternal pre-pregnancy body mass index (BMI), gestational weight gain, gestational diabetes, birth weight, gestational age and feeding mode. RESULTS: Factors associated with greater D3WL, whatever the feeding mode, were: higher birth weight, gestational diabetes and caesarean section; higher gestational age was associated with a reduced D3WL. The association between maternal pre-pregnancy BMI and D3WL differed by feeding mode (interaction p value=0.0002). In breastfed babies, mean D3WL ranged from 4.9% for neonates of underweight mothers to 5.8% for neonates of obese mothers (p trend=0.0005). In formula-fed babies, D3WL was highest for neonates of underweight mothers (4.1%) and lowest for those of obese mothers (2.6%) (p trend=0.01). CONCLUSIONS: The lower D3WL in formula-fed neonates, especially in neonates of obese mothers, suggests a relative overfeeding in the early days compared with breastfed neonates, which may potentially have consequences on later health. Overweight and obese mothers may need extra support to prevent early breastfeeding discontinuation.
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- 2011
90. Laborem Box: A scalable and open source platform to design remote lab experiments in electronics.
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Lavayssière C, Larroque B, and Luthon F
- Abstract
Hybrid teaching (face-to-face and distance learning) enables students to better prepare and complete their courses. In science, technology, engineering and mathematics, it is important that practical training be an integral part of the curriculum. Laborem project developed at the technological university institute in Bayonne, France, enables undergraduate students to carry out part of their lab experiments in electronics remotely. Started in 2011, Laborem platform was based on proprietary solutions. Since 2017, the platform has migrated to open source software (PyScada) and open source interface box (Laborem Box), which was developed in order to enable the connection of several circuit boards to be studied. These boards, called plugs, are easily interchangeable and enable teachers to quickly adapt the proposed circuits to their course. The software also provides a simple front panel to adapt the human machine interface that is available for students. Laborem Box consists of a 3D printable box, a power supply board, a set of plugs, and a motherboard that enables students to study the selected plug. In addition, a single board computer is embedded and a hard disk can be used if necessary. This paper is intended to describe the hardware and software design of Laborem platform, and to serve as a guide to explain how to duplicate and deploy this system, primarily dedicated to undergraduate students for learning basic electronics., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 The Authors.)
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- 2022
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91. Developmental milestones at one year for the offspring of mothers with congenital hypothyroidism: a population-based study
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Léger J, Forhan A, Dos Santos S, Larroque B, Ecosse E, Charles MA, and Heude B
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- Adult, Cohort Studies, Congenital Hypothyroidism blood, Congenital Hypothyroidism drug therapy, Female, France epidemiology, Hormone Replacement Therapy, Humans, Infant, Newborn, Language Development Disorders epidemiology, Language Development Disorders etiology, Longitudinal Studies, Male, Motor Skills Disorders epidemiology, Pregnancy, Pregnancy Complications blood, Pregnancy Complications drug therapy, Prospective Studies, Registries, Risk, Severity of Illness Index, Thyroid Gland metabolism, Thyrotropin blood, Thyrotropin metabolism, Thyroxine therapeutic use, Congenital Hypothyroidism physiopathology, Motor Skills Disorders etiology, Pregnancy Complications physiopathology, Thyroid Gland physiopathology
- Abstract
Objective: Maternal thyroid dysfunction during pregnancy is associated with neurodevelopmental impairment in the offspring. No data are currently available for the offspring of patients treated early for congenital hypothyroidism (CH). The aim of this study was to investigate motor and language milestones at one year of age in a population-based registry of children born to young women with CH., Design and Methods: We assessed 110 children born to mothers with CH, and 1367 children from the EDEN French population-based birth cohort study prospectively, at the age of one year, with identical questionnaires. Outcomes were assessed in terms of scores for childhood developmental milestones relating to mobility, motor coordination, communication, motricity and language skills., Results: After adjustment for confounding factors, children born to mothers with CH were found to have a higher risk of poor motor coordination than those of the EDEN cohort (OR: 4.18, 95% CI: 2.52-6.93). No differences were identified for the other four domains investigated. Children born to mothers with gestational diabetes have a higher risk of low motor coordination score than their peers (OR: 2.10, 95% CI: 1.21-3.66). Children born to mothers with TSH ≥ 10 IU/L during the first six months of pregnancy were more likely to have low motricity or communication skills scores than those born to mothers with lower TSH concentrations (56% vs 21% for each score, P < 0.04)., Conclusions: Maternal CH may have slight adverse effects on some developmental milestones in the child at one year of age, particularly for children born to mothers with uncontrolled hypothyroidism. However, it remains unclear whether these adverse effects modify subsequent neurodevelopment., (© 2018 European Society of Endocrinology.)
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- 2018
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92. Social Withdrawal Behaviour at One Year of Age Is Associated with Delays in Reaching Language Milestones in the EDEN Mother-Child Cohort Study.
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Guedeney A, Forhan A, Larroque B, de Agostini M, Pingault JB, and Heude B
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- Adult, Female, Humans, Infant, Male, Prospective Studies, Language Development Disorders psychology, Mother-Child Relations, Social Behavior
- Abstract
Objective: The aim of the study was to examine the relationship between social withdrawal behaviour at one year and motor and language milestones., Materials and Methods: One-year old children from the EDEN French population-based birth cohort study (Study on the pre- and postnatal determinants of the child's development and prospective health Birth Cohort Study) were included. Social withdrawal at one year was assessed by trained midwives using the Alarm Distress BaBy (ADBB) scale. Midwives concurrently examined infants' motor and language milestones. Parents reported on child's psychomotor and language milestones, during the interview with the midwife., Results: After adjusting for potential confounding factors, social withdrawal behaviour was significantly associated with concurrent delays in motor and language milestones assessed by the midwife or the parents., Discussion: Higher scores on social withdrawal behaviour as assessed with the ADBB were associated with delays in reaching language milestones, and to a lesser extent with lower motor ability scores. Taking the contribution of social withdrawal behaviour into account may help understand the unfolding of developmental difficulties in children.
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- 2016
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93. Maternal Depression Trajectories and Children's Behavior at Age 5 Years.
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van der Waerden J, Galéra C, Larroque B, Saurel-Cubizolles MJ, Sutter-Dallay AL, and Melchior M
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- Adult, Child, Preschool, Cohort Studies, Female, Humans, Male, Surveys and Questionnaires, Time Factors, Child Behavior Disorders epidemiology, Depression, Mothers
- Abstract
Objective: To assess the relationship between trajectories of maternal depression from pregnancy to the child's age of 5 years and children's emotional and behavioral difficulties at age 5 years., Study Design: Mother-child pairs (n = 1183) from the EDEN mother-child birth cohort study based in France were followed from 24 to 28 weeks of pregnancy to the child's fifth birthday. Children's behavior at age 5 years was assessed with the Strengths and Difficulties Questionnaire. Maternal depression was assessed repeatedly with the Center for Epidemiological Studies Depression questionnaire (pregnancy, 3, and 5 years of age) and the Edinburgh Postnatal Depression Scale (4, 8, and 12 months postpartum). Homogeneous latent trajectory groups of maternal depression were identified within the study population and correlated with Strengths and Difficulties Questionnaire scores by the use of multivariate linear regression analyzes., Results: Five trajectories of maternal symptoms of depression were identified: no symptoms (62.0%); persistent intermediate-level depressive symptoms (25.3%); persistent high depressive symptoms (4.6%); high symptoms in pregnancy only (3.6%); and high symptoms in the child's preschool period only (4.6%). Children whose mothers had persistent depressive symptoms--either intermediate or high--had the greatest levels of emotional and behavioral difficulties at age 5 years. In addition, compared with children whose mothers were never depressed, those whose mothers had high symptoms in the preschool period also had increased levels of emotional symptoms, conduct problems, and peer problems., Conclusions: Maternal depression symptoms are related to children's emotional and behavioral problems, particularly if they are persistent (29.9%) or occur during early childhood (4.6%)., (Copyright © 2015 Elsevier Inc. All rights reserved.)
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- 2015
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94. Developmental predictors of inattention-hyperactivity from pregnancy to early childhood.
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Foulon S, Pingault JB, Larroque B, Melchior M, Falissard B, and Côté SM
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- Child Development, Child, Preschool, Cohort Studies, Female, France epidemiology, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Maternal Exposure, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Surveys and Questionnaires, Hyperkinesis epidemiology, Hyperkinesis etiology
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Objective: The objective of the study was to characterize the developmental sequence of pre- and postnatal risk factors for inattention-hyperactivity symptoms in preschoolers., Materials and Methods: Longitudinal data came from a French population based birth cohort study (EDEN; N = 1311 mother-child pairs followed from the pregnancy onwards). Inattention-hyperactivity symptoms were assessed with the Strengths and Difficulties Questionnaire when participating children were 3 years of age. Potential risk factors were classified in four domains (fetal exposures and child somatic characteristics, child temperament, child neurodevelopmental status, psychosocial environment) and four periods (before pregnancy, prenatal/birth, infancy, toddlerhood). Their role as potential moderator or mediator was tested with path analysis to determine the developmental sequence., Results: A low family socioeconomic status before pregnancy was the main environmental risk factor for inattention-hyperactivity symptoms at 3 years, and its effect occurred via two pathways. The first was a risk pathway, where lower SES was associated with higher maternal depression and anxiety during pregnancy; then to higher maternal and child distress and dysregulation in infancy; and in turn to higher levels of inattention-hyperactivity at 3 years. The second was a protective pathway, where higher SES was associated with longer duration of breastfeeding during infancy; then to better child neurodevelopmental status in toddlerhood; and in turn to lower levels of inattention-hyperactivity at 3 years., Discussion: This study identified psychosocial factors at several developmental periods that represent potential targets for preventing the emergence of inattention-hyperactivity symptoms in early childhood.
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- 2015
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95. Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas.
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Goutagny S, Raymond E, Esposito-Farese M, Trunet S, Mawrin C, Bernardeschi D, Larroque B, Sterkers O, Giovannini M, and Kalamarides M
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- Adolescent, Adult, Antineoplastic Agents adverse effects, Biomarkers, Tumor metabolism, Cranial Nerve Neoplasms pathology, Cranial Nerve Neoplasms physiopathology, Disease Progression, Disease-Free Survival, Everolimus adverse effects, Female, Follow-Up Studies, Humans, Male, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes antagonists & inhibitors, Multiprotein Complexes metabolism, Neurilemmoma pathology, Neurilemmoma physiopathology, Neurofibromatosis 2 pathology, Neurofibromatosis 2 physiopathology, Prospective Studies, TOR Serine-Threonine Kinases antagonists & inhibitors, TOR Serine-Threonine Kinases metabolism, Treatment Outcome, Tumor Burden, Vestibulocochlear Nerve Diseases pathology, Vestibulocochlear Nerve Diseases physiopathology, Young Adult, Antineoplastic Agents therapeutic use, Cranial Nerve Neoplasms drug therapy, Everolimus therapeutic use, Neurilemmoma drug therapy, Neurofibromatosis 2 drug therapy, Vestibulocochlear Nerve Diseases drug therapy
- Abstract
Neurofibromatosis type 2 (NF2) is a genetic disorder with bilateral vestibular schwannomas (VS) as the most frequent manifestation. Merlin, the NF2 tumor suppressor, was identified as a negative regulator of mammalian target of rapamycin complex 1. Pre-clinical data in mice showed that mTORC1 inhibition delayed growth of NF2-schwannomas. We conducted a prospective single-institution open-label phase II study to evaluate the effects of everolimus in ten NF2 patients with progressive VS. Drug activity was monitored every 3 months. Everolimus was administered orally for 12 months and, if the decrease in tumor volume was >20 % from baseline, treatment was continued for 12 additional months. Other patients stopped when completed 12 months of everolimus but were allowed to resume treatment when VS volume was >20 % during 1 year follow-up. Nine patients were evaluable. Safety was evaluated using CTCAE 3.0 criteria. After 12 months of everolimus, no reduction in volume ≥20 % was observed. Four patients had progressive disease, and five patients had stable disease with a median annual growth rate decreasing from 67 %/year before treatment to 0.5 %/year during treatment. In these patients, tumor growth resumed within 3-6 months after treatment discontinuation. Everolimus was then reintroduced and VS decreased by a median 6.8 % at 24 months. Time to tumor progression increased threefold from 4.2 months before treatment to > 12 months. Hearing was stable under treatment. The safety of everolimus was manageable. Although the primary endpoint was not reached, further studies are required to confirm the potential for stabilization of everolimus.
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- 2015
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96. Pregnancy outcomes and relationship to treatment adequacy in women treated early for congenital hypothyroidism: a longitudinal population-based study.
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Léger J, dos Santos S, Larroque B, and Ecosse E
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- Adult, Congenital Hypothyroidism diagnosis, Early Diagnosis, Female, France epidemiology, Hormone Replacement Therapy, Humans, Infant, Newborn, Longitudinal Studies, Male, Pregnancy, Pregnancy Complications diagnosis, Young Adult, Congenital Hypothyroidism drug therapy, Congenital Hypothyroidism epidemiology, Pregnancy Complications drug therapy, Pregnancy Complications epidemiology, Pregnancy Outcome epidemiology, Thyroxine therapeutic use
- Abstract
Context: Untreated hypothyroidism is associated with a higher risk of adverse obstetric and neonatal outcomes. Pregnancy complications have yet to be evaluated in patients treated early for congenital hypothyroidism (CH)., Objective: This study aimed to investigate pregnancy outcomes and their determinants in a population-based registry of young adult women with CH., Setting and Design: In total, 1748 subjects were diagnosed with CH in the first 10 years after the introduction of neonatal screening in France; 1158 of these subjects completed a questionnaire on fecundity at a mean age of 25.3 years. We analyzed all declared singleton pregnancies ending after greater than 22 weeks of gestation before the initial survey (n = 207 pregnancies) and in the 3 years following the initial survey (prospective study, n = 174 pregnancies). The reference group comprised 7245 subjects from the French National Perinatal Survey., Main Outcome Measures: Pregnancy outcomes. Serum TSH concentrations and thyroid hormone requirements., Results: In both the overall and prospective analyses, CH was associated with gestational hypertension, emergency cesarean delivery, induced labor for vaginal delivery, and prematurity. For the prospective population with CH, the adjusted odds ratios (aOR) (95% confidence interval [CI]) were 2.19 (1.26-3.81), 1.88 (1.17-3.02), 1.58 (1.12-2.24), and 1.85 (1.06-3.25), respectively. TSH concentrations at least 10 mIU/l during the first 3 or 6 months of pregnancy were associated with a higher risk of preterm delivery (aOR, 5.6; 95% CI, 1.6-20.0) and fetal macrosomia (aOR, 4.5; 95% CI, 1.03-20.1), respectively, whereas no such relationship was observed for TSH concentrations of 5.0-9.9 mIU/l., Conclusion: CH may result in adverse pregnancy outcomes. These nationwide data suggest that better thyroid disease management is required, particularly during the first two trimesters of pregnancy, together with vigilant monitoring.
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- 2015
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97. Reproductive disorders in hairdressers and cosmetologists: a meta-analytical approach.
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Henrotin JB, Picot C, Bouslama M, Collot-Fertey D, Radauceanu A, Labro MT, Larroque B, Roudot AC, Sater N, Elhkim MO, and Lafon D
- Subjects
- Adult, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Pregnancy, Premature Birth, Reproduction, Risk Factors, Beauty Culture, Occupational Diseases etiology, Pregnancy Complications etiology, Pregnancy Outcome
- Abstract
Objectives: The aim of this study was to perform a systematic review and to use a meta-analytical approach to assess quantitatively the risk of adverse pregnancy outcomes in hairdressers and cosmetologists., Methods: A systematic literature search up to 1 February 2012 was carried out using major bibliographic databases, grey literature, contacts with research teams working on the subject, review papers and reference lists of selected articles. Observational studies reporting measures of effects in relation with body care (hairdressers, cosmetologists, etc.) and reproductive disorders were included. Study quality was assessed by three reviewers. The estimated risk ratios (RR) from all studies reporting on identical outcomes were combined using an average of logarithm transformation of estimated RR weighted by their inverted variance. Statistical heterogeneity across studies was assessed using Cochran's Q test. To explore the sources of heterogeneity, several sensitivity analyses and subgroup analyses were conducted based on study quality, country, study period, alcohol consumption, smoking habit, jobs and control populations., Results: Nineteen studies were selected and reviewed in-depth. The combined risk ratios (RRcs) of five reproductive outcomes were calculated and found to be significantly increased for four outcomes: time to pregnancy, which had an RRc of 1.11 (95% CI: 1.03-1.19); premature birth, which had an RRc of 1.05 (95% CI: 0.99-1.11); small for gestational age, which had an RRc of 1.24 (95 CI%: 1.10-1.41); low birth weight, which had an RRc of 1.21 (95% CI: 1.06-1.39); and embryonic and fetal losses, which had an RRc of 1.19 (95% CI: 1.03-1.38)., Conclusions: This work confirms a weak increase in risk of some reproductive disorders in female hairdressers/cosmetologists. However, the evidence level is rather weak, and a causal association between job and reproductive outcomes cannot be asserted.
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- 2015
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98. Social withdrawal at 1 year is associated with emotional and behavioural problems at 3 and 5 years: the Eden mother-child cohort study.
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Guedeney A, Pingault JB, Thorr A, and Larroque B
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- Child, Child Behavior Disorders psychology, Child, Preschool, Emotions, Female, France, Humans, Infant, Longitudinal Studies, Male, Mothers, Parent-Child Relations, Parents, Prospective Studies, Risk Factors, Surveys and Questionnaires, Child Behavior Disorders diagnosis, Child Behavior Disorders etiology, Infant Behavior, Social Behavior, Temperament
- Abstract
The objective of the study was to examine how social withdrawal in infants aged 12 months predicted emotional and behavioural problems at ages 3 and 5 years. The sample included 1,586 infants from the French Eden Mother-Child Cohort Study who had a measure of social withdrawal with the Alarm Distress BaBy scale at age 1 year; among these children, emotional and behavioural difficulties were rated by mothers using the Strength and Difficulty Questionnaire (SDQ) at 3 years for 1,257 (79 %) children and at 5 years for 1,123 (72 %) children. Social withdrawal behaviour at age 1 year was significantly associated with the SDQ behavioural disorder scale at 3 years, independently of a host of familial and child temperament confounders. The association with the relational disorder, prosocial and total difficulty scales was close to significance at 3 years after taking into account familial and temperament confounders. Social withdrawal significantly predicted the three aforementioned scales when measured at 5 years. No significant predictivity of the emotional scale and hyperactivity scale was detected at any age. This study made with a large longitudinal sample confirms the negative effects on development of social withdrawal behaviour, shedding light on the unfolding of behavioural disorders and relational difficulties in children; this calls for early detection of sustained social withdrawal behaviour, as it seems to hamper emotional development.
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- 2014
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99. Glycemic instability of non-diabetic patients after spine surgery: a prospective cohort study.
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Langlois J, Bouyer B, Larroque B, Dauzac C, and Guigui P
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- Adult, Age Factors, Blood Loss, Surgical, Blood Transfusion, Female, Follow-Up Studies, Humans, Male, Middle Aged, Operative Time, Prospective Studies, Reoperation, Smoking blood, Blood Glucose analysis, Postoperative Complications, Spine surgery
- Abstract
Purpose: Blood glucose (BG) dysregulation is a well-known condition for patients sustaining medical adverse events, such as sepsis or myocardial infarction. However, it has never been described following spine surgery. Our purpose was to assess postoperative glycemic dysregulation of non-diabetic patients undergoing spine surgery and determine if this is related to any complications within a 3-month postoperative period., Methods: All the non-diabetic patients undergoing spine surgery in our center were prospectively included over a 6-month period. BG capillary measures were collected from the preoperative fasting period to the end of postoperative Day 3, six times a day. Patients were followed for 3 months after surgery., Results: Data collected from 75 patients were eventually analyzed. A significant increase of BG level was observed from the preoperative to the second postoperative hour (P < 0.0001), remaining significantly elevated until Day 3 (P < 0.0001). Significant correlations were found between perioperative factors (age, smoking, revision status, instrumentation, operation time, blood loss and transfusion) and glycemic parameters. Day 2 mean BG level was found significantly higher for patients surgically revised than those not revised (P = 0.04)., Conclusions: Non-diabetic patients experience a statistically significant increase in BG levels in the first 3 days following a spine surgery. This increase in BG might be correlated with postsurgical complications.
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- 2014
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100. Type 2 diabetes mellitus as a risk factor for intestinal resection in patients with superior mesenteric vein thrombosis.
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Elkrief L, Corcos O, Bruno O, Larroque B, Rautou PE, Zekrini K, Bretagnol F, Joly F, Francoz C, Bondjemah V, Cazals-Hatem D, Boudaoud L, De Raucourt E, Panis Y, Goria O, Hillaire S, Valla D, and Plessier A
- Subjects
- Anticoagulants therapeutic use, Female, Humans, Intestines pathology, Ischemia epidemiology, Ischemia etiology, Male, Mesenteric Ischemia diagnostic imaging, Middle Aged, Retrospective Studies, Risk Factors, Statistics, Nonparametric, Tomography, X-Ray Computed, Diabetes Mellitus, Type 2 epidemiology, Intestines surgery, Ischemia pathology, Ischemia surgery, Mesenteric Ischemia complications
- Abstract
Background & Aims: The most serious complication of acute mesenteric vein thrombosis (MVT) is acute intestinal ischaemia requiring intestinal resection or causing death. Risk factors for this complication are unknown. To identify risk factors for severe intestinal ischaemia leading to intestinal resection in patients with acute MVT., Methods: We retrospectively analysed consecutive patients seen between 2002 and 2012 with acute MVT in 2 specialized units. Patients with cirrhosis were excluded. We compared patients who required intestinal resection to patients who did not., Results: Among 57 patients, a local risk factor was identified in 14 (24%) patients, oral contraceptive use in 16 (29%), and at least one or more other systemic prothrombotic condition in 25 (44%). Five (9%) patients had diabetes mellitus (DM), 33 (58%) had overweight or obesity, 9 (18%) had hypertriglyceridemia and 10 (19%) had arterial hypertension. Eleven patients (19%) underwent intestinal resection. DM was significantly associated with intestinal resection (P = 0.02) while local factors or prothrombotic conditions were not. Computed tomography (CT) scans performed at diagnosis found that occlusion of second order radicles of the superior mesenteric vein was more frequently observed in patients who underwent intestinal resection (P = 0.009)., Conclusions: In acute MVT, patients with underlying DM have an increased risk of requiring intestinal resection. Neither local factors nor systemic prothrombotic conditions are associated with intestinal resection. When CT scan shows the preservation of second order radicles of the superior mesenteric vein, the risk of severe resection is low., (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2014
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