363 results on '"Lahary, A."'
Search Results
52. Numerous Heinz bodies in a case of infantile pyknocytosis
- Author
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Bobée, Victor, primary and Lahary, Agnès, primary
- Published
- 2020
- Full Text
- View/download PDF
53. Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches
- Author
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Velic, Denis, primary, Charlier, Cathy, additional, Popova, Milena, additional, Jaunet-Lahary, Titouan, additional, Bouchouireb, Zakaria, additional, Henry, Sébastien, additional, Weigel, Pierre, additional, Masson, Jean-Yves, additional, Laurent, Adèle, additional, Nabiev, Igor, additional, and Fleury, Fabrice, additional
- Published
- 2019
- Full Text
- View/download PDF
54. Quaternary structure sensitive tyrosine residues in human hemoglobin: UV resonance Raman studies of mutants at alpha140, beta35, and beta145 tyrosine
- Author
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Nagai, Masako, Wajcman, Henri, Lahary, Agnes, Nakatsukasa, Takashi, Nagatomo, Shigenori, and Kitagawa, Teizo
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Tyrosine -- Research ,Hemoglobin -- Research ,Raman spectroscopy -- Usage ,Gene mutations -- Research ,Biological sciences ,Chemistry - Abstract
The observed ultraviolet resonance Raman (UVRR) spectral changes in the tyrosine (Tyr) residue of human hemoglobin A (HbA) were investigated. The Fe-His stretching mode demonstrated that mutant Hbs take the T structure in the deoxy form. Findings indicate that alpha140Tyr is responsible for the frequency shift and the intensity changes in the spectra. The frequency shift of the Tyr RR bands on the T-R transition may be attributed to changes in the hydrogen bonding state of alpha42 and alpha140Tyr.
- Published
- 1999
55. Hodgkin lymphoma in a sickle cell anaemia child treated with hydroxyurea
- Author
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Couronné, L., Schneider, P., de Montalembert, M., Dumesnil, C., Lahary, A., and Vannier, J. P.
- Published
- 2009
- Full Text
- View/download PDF
56. An Additional Case of Hb Saint Nazaire [β103(G5)Phe→Ile;
- Author
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Victor, Bobée, Guillaume, Feugray, Valéry, Brunel, Philippe, Joly, and Agnès, Lahary
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Adult ,Erythrocyte Indices ,Heterozygote ,Amino Acid Substitution ,Hemoglobins, Abnormal ,DNA Mutational Analysis ,Mutation ,Humans ,Family ,France ,Polycythemia ,Child ,Alleles - Abstract
We report two members of a French family who are carriers of a rare hemoglobin (Hb) variant leading to erythrocytosis: Hb Saint Nazaire [β103(G5)Phe→Ile
- Published
- 2019
57. Clinical and biological features in PIEZO1-hereditary xerocytosis and Gardos channelopathy: a retrospective series of 126 patients
- Author
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Agnès Lahary, Jean-Pierre de Jaureguiberry, Fabienne Toutain, Véronique Picard, Patricia Aguilar-Martinez, Bertrand Godeau, Xavier Jaïs, Catherine Badens, Robert Maffre, Christian Rose, Isabelle Thuret, François Lifermann, Corinne Guitton, Frédéric Galactéros, Gilles Morin, Nadia Firah, Marc Ruivard, Claire Berger, Valérie Proulle, Camille Le Stradic, Pascal Cathébras, Laurence Bendelac, Jacques Delaunay, Julien Perrin, Claire Barro, Claire Bénéteau, Eric Deconinck, Khaldoun Ghazal, Loïc Garçon, Jean-Marc Durand, roussel, pascale, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Université Paris-Saclay, Service de pédiatrie, d'hématologie et d'oncologie [Hôpital de La Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Saint Vincent de Paul de Lille, Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Département d'hématologie biologique[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Grenoble, Service de génétique médicale - Unité de génétique clinique [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Saint-Etienne, Centre Catherine-de-Sienne [Nantes] (CCS), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre hospitalier de Pau, Hôpital Henri Mondor, Hopital d'instruction des armées Sainte-Anne [Toulon] (HIA), Université de Bretagne Sud (UBS), Centre Hospitalier de Dax, CHU Amiens-Picardie, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, CHU Pontchaillou [Rennes], CHU Rouen, Normandie Université (NU), Université de Picardie Jules Verne (UPJV), Groupe Hospitalier de l'Institut Catholique de Lille (GHICL), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi, and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
- Subjects
Male ,[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology ,Pediatrics ,medicine.medical_specialty ,Iron Overload ,Anemia ,Hydrops Fetalis ,medicine.medical_treatment ,Splenectomy ,Mutation, Missense ,Disease ,Anemia, Hemolytic, Congenital ,Hemolysis ,Article ,Ion Channels ,03 medical and health sciences ,0302 clinical medicine ,Channelopathy ,Pregnancy ,Edema ,Humans ,Medicine ,Missense mutation ,Family ,Retrospective Studies ,030304 developmental biology ,0303 health sciences ,business.industry ,Red Cell & its Disorders ,Thrombosis ,Retrospective cohort study ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Hematology ,Intermediate-Conductance Calcium-Activated Potassium Channels ,medicine.disease ,3. Good health ,Mutation ,Mutation (genetic algorithm) ,Channelopathies ,Female ,business ,030215 immunology - Abstract
International audience; We describe the clinical, hematologic and genetic characteristics of a retrospective series of 126 subjects from 64 families with hereditary xerocytosis. Twelve patients from six families carried a KCNN4 mutation, five had the recurrent p.Arg352His mutation and one had a new deletion at the exon 7-intron 7 junction. Forty-nine families carried a PIEZO1 mutation, which was a known recurrent mutation in only one-third of the cases and private sequence variation in others; 12 new probably pathogenic missense mutations were identified. The two dominant features leading to diagnosis were hemolysis that persisted after splenectomy and hyperferritinemia, with an inconstant correlation with liver iron content assessed by magnetic resonance imaging. PIEZO1-hereditary xerocytosis was characterized by compensated hemolysis in most cases, perinatal edema of heterogeneous severity in more than 20% of families and a major risk of post-splenectomy thrombotic events, including a high frequency of portal thrombosis. In KCNN4-related disease, the main symptoms were more severe anemia, hemolysis and iron overload, with no clear sign of red cell dehydration; therefore, this disorder would be better described as a ‘Gardos channelopathy’. These data on the largest series to date indicate that PIEZO1-hereditary xerocytosis and Gardos channelopathy are not the same disease although they share hemolysis, a high rate of iron overload and inefficient splenectomy. They demonstrate the high variability in clinical expression as well as genetic bases of PIEZO1-hereditary xerocytosis. These results will help to improve the diagnosis of hereditary xerocytosis and to provide recommendations on the clinical management in terms of splenectomy, iron overload and pregnancy follow-up.
- Published
- 2019
58. A. Lexique des ressources d’Internet
- Author
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Caraco, Alain, primary and Lahary, Dominique, additional
- Published
- 2000
- Full Text
- View/download PDF
59. G. Signaler les ressources d’Internet dans le catalogue
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Lahary, Dominique, primary
- Published
- 2000
- Full Text
- View/download PDF
60. Dose-dependent effect of dehydroepiandrosterone, but not of its sulphate ester, on angiogenesis
- Author
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Varet, Julia, Vincent, Loïc, Akwa, Yvette, Mirshahi, Pezhman, Lahary, Agnès, Legrand, Elizabeth, Opolon, Paule, Mishal, Zohair, Baulieu, Etienne-Emile, Soria, Jeannette, Soria, Claudine, and Li, Hong
- Published
- 2004
- Full Text
- View/download PDF
61. A painless, sudden loss of vision in sickle cell anaemia: central retinal artery occlusion
- Author
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Agnes Lahary, Ozlem Ozkul-Wermester, Edouard Malandain, Linda Zourdani, and Maxime Guillaume
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medicine.medical_specialty ,medicine.diagnostic_test ,Computed Tomography Angiography ,Retinal Artery Occlusion ,Anemia ,business.industry ,Carotid arteries ,Anemia, Sickle Cell ,General Medicine ,Middle Aged ,medicine.disease ,Text mining ,medicine ,Humans ,Central retinal artery occlusion ,Carotid Stenosis ,Female ,Tomography ,Radiology ,business ,Carotid Artery, Internal ,Tomography, Optical Coherence ,Computed tomography angiography - Published
- 2021
62. A Joint Theoretical and Experimental Study of the Behavior of the DIDS Inhibitor and its Derivatives
- Author
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Anaïs Goupille, Fabrice Fleury, Titouan Jaunet-Lahary, Jérôme Graton, Denis Jacquemin, Adèle D. Laurent, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Mécanisme et régulation de la réparation de l’ADN [Nantes], Unité de fonctionnalité et ingénierie de protéines (UFIP), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Models, Molecular ,vibronic couplings ,Protonation ,4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid ,010402 general chemistry ,Photochemistry ,01 natural sciences ,chemistry.chemical_compound ,Isomerism ,Computational chemistry ,0103 physical sciences ,stilbene sulfonic acid ,Physical and Theoretical Chemistry ,010304 chemical physics ,Vis spectroscopy ,Atomic and Molecular Physics, and Optics ,Redshift ,UV ,0104 chemical sciences ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,Solvent ,Wavelength ,Vibronic coupling ,chemistry ,Spectrophotometry ,DIDS ,density functional calculations ,Quantum Theory ,Thermodynamics ,Density functional theory ,Protons ,solvent reorganization ,Cis–trans isomerism - Abstract
International audience; 4,4-Diisothiocyanostilbene-2,2-disulfonic acid (DIDS) is a well-known ion-exchange inhibitor targeting cardiac functions and indirectly impeding both radio- and chemo-resistance. A joint computational and experimental study is presented to provide deeper insights into DIDS and other members of this family of compounds. To this end, we applied state-of-the-art density functional theory (DFT) and time-dependent DFT methods, in addition to measuring the optical properties. The experimental data show that such compounds are highly sensitive to their environment and that the optical properties change within as little time as 7h. However, the optical properties of DIDS are similar in various acidic/basic environments, which were confirmed by pK(a) computations on both cis and trans isomers. The protonation analysis also highlights that the singly protonated form of DIDS behaves like a proton sponge compound. The experimentally observed redshift that can be seen when going from water to DMSO was reproduced solely by using the solvation model based on density, although the polarization continuum model and implicit/explicit hybrid schemes were also tested. The characteristic broadening of the absorption peak in water and the vibronic fine structure in DMSO were also reproduced thanks to vibronic coupling simulations associated with the solvent reorganization energy. For other stilbene derivatives, a correlation is found between the maximum absorption wavelength and the Hammett parameters.
- Published
- 2016
63. [Delayed haemolytic transfusion reaction: About 3 patients with sickle cell disease]
- Author
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M. Al Bagami, E. Bertrand, H. Lévesque, C. Dumesnil, Agnès Lahary, J.-P. Vannier, P. Schneider, Hôpital Charles Nicolle [Rouen], Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,[SDV]Life Sciences [q-bio] ,Gastroenterology ,030204 cardiovascular system & hematology ,Haemolysis ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Intravenous Immunoglobulins ,Internal Medicine ,medicine ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,business ,ComputingMilieux_MISCELLANEOUS ,030215 immunology - Abstract
Resume Introduction Le recours a une transfusion de culots de globules rouges chez un patient drepanocytaire majeur est parfois indispensable. L’hemolyse post-transfusionnelle retardee est une complication rare mais potentiellement grave. Cette manifestation peut survenir a tout âge. Elle est probablement sous-diagnostiquee du fait du peu de signes specifiques. Observations Nous decrivons dans cet article, les signes cliniques, biologiques et les aleas de la prise en charge therapeutique de trois cas d’hemolyse post-transfusionnelle retardee. La chromatographie haute performance evaluant le pourcentage d’HbA1 est l’examen permettant d’etablir le diagnostic. La physiopathologie de cet evenement est encore mal connue. Plusieurs traitements ont ete utilises, cependant, la prise en charge therapeutique reste discutee a l’heure actuelle. Conclusion La transfusion de tout patient susceptible d’avoir une hemolyse post-transfusionnelle retardee est fortement deconseillee car elle risque d’aggraver l’hemolyse. La prevention d’une recidive est primordiale.
- Published
- 2015
64. Numerous Heinz bodies in a case of infantile pyknocytosis
- Author
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Agnès Lahary and Victor Bobée
- Subjects
Anthropology ,business.industry ,Pycnodysostosis ,Immunology ,Infant, Newborn ,Cell Biology ,Hematology ,Biochemistry ,Infantile Pyknocytosis ,Humans ,Medicine ,business ,Heinz Bodies ,Heinz body - Published
- 2020
65. Chapitre 3. Solubilités du bibliothécaire
- Author
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Lahary, Dominique and Mesguich, Véronique
- Subjects
bibliothécaire ,construction ,pratiques documentaires ,production de savoirs ,LAW025000 ,évolution du métier de bibliothécaire ,Information Science & Library Science ,bibliothèque ,LNAA - Abstract
Parcours 5. Métier, métiers, proposé par Dominique Lahary Bertrand Calenge est un formateur. Pas seulement parce qu’il a dirigé l’Institut de formation des bibliothécaires (INFB) et exercé à l’Enssib. Plus profondément, parce qu’au-delà des différentes responsabilités qu’il a exercées, il n’a eu de cesse de rechercher, se documenter, documenter, produire,...
- Published
- 2018
66. Calenge par Bertrand, parcours de lecture dans le Carnet d’un bibliothécaire
- Author
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Aïoutz, Renaud, Calenge, Bertrand, Caraco, Alain, Goussard, Aline, Lahary, Dominique, Mesguich, Véronique, Muller, Joëlle, Pouchol, Jérôme, Pouchol, par Jérôme, and Poulain, Martine
- Subjects
bibliothécaire ,construction ,pratiques documentaires ,production de savoirs ,LAW025000 ,évolution du métier de bibliothécaire ,Information Science & Library Science ,bibliothèque ,LNAA - Abstract
Nous sommes tous redevables à Bertrand Calenge, bibliothécaire de renom, théoricien et praticien des bibliothèques, disparu en 2016. Un collectif de bibliothécaires fait revivre cet auteur, en proposant un parcours de lecture à travers son blog Carnet de notes. Ces parcours thématiques et transversaux recontextualisent les billets selon les principaux sujets traités par l’auteur – collections, médiation, évaluation, métier, numérique, etc. – autant dire toutes les questions vives des bibliothèques. Ce livre expérimente une mise en book du blog d’un professionnel, pour nous inviter, comme l'écrit Martine Poulain dans sa préface, « à penser, échanger, proposer ».
- Published
- 2018
67. Chapitre 4. Carnet de notes en contextes
- Author
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Lahary, Dominique and Goussard, Aline
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bibliothécaire ,construction ,pratiques documentaires ,production de savoirs ,LAW025000 ,évolution du métier de bibliothécaire ,Information Science & Library Science ,bibliothèque ,LNAA - Abstract
Parcours 8. De Biblio-fr à l’info-blogosphère : chaîne unique et multicanaux, proposé par Dominique Lahary Il faut s’imaginer le monde d’avant ou se le remémorer si on l’a connu. Une communauté professionnelle, prenons les bibliothécaires, n’avait pour s’informer, capitaliser, faire doctrine et débat, que le papier sous forme de livres et périodiques. Ainsi que les rencontres bi...
- Published
- 2018
68. Computational simulations determining disulfonic stilbene derivative bioavailability within human serum albumin
- Author
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Daniel P Vercauteren, Fabrice Fleury, Titouan Jaunet-Lahary, Adèle D. Laurent, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Unité de Biotechnologie, Biocatalyse et Biorégulation (U3B), and Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
0301 basic medicine ,Stereochemistry ,Protein Conformation ,Serum albumin ,General Physics and Astronomy ,Serum Albumin, Human ,Plasma protein binding ,Molecular Dynamics Simulation ,010402 general chemistry ,Ligands ,01 natural sciences ,Molecular Docking Simulation ,03 medical and health sciences ,Protein structure ,Stilbenes ,medicine ,Humans ,Computer Simulation ,Physical and Theoretical Chemistry ,Binding site ,ComputingMilieux_MISCELLANEOUS ,biology ,Ligand ,Human serum albumin ,0104 chemical sciences ,3. Good health ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,030104 developmental biology ,biology.protein ,Drug carrier ,medicine.drug ,Protein Binding - Abstract
Disulfonic stilbene (DS) derivatives are a member of the large family of compounds widely employed in medicine and biology as modulators for membrane transporters or inhibitors of a protein involved in DNA repair. They constitute interesting compounds that have not yet been investigated within the bioavailability framework. No crystallographic structures exist involving such compounds embedded in the most common drug carrier, human serum albumin (HSA). The present work studies, for the first time, the physico-chemical features driving the inclusion of three DS derivatives (amino, nitro and acetamido, named DADS, DNDS and DATDS, respectively) within the four common HSA binding sites using combined molecular docking and molecular dynamics simulations. A careful analysis of each ligand within each of the studied binding sites is carried out, highlighting specific interactions and key residues playing a role in stabilizing the ligand within each pocket. The comparison between DADS, DNDS and DATDS reveals that depending on the binding site, the conclusions are rather different. For instance, the IB binding site shows a specificity to DADS compounds while IIIA is the most favorable site for DNDS and DATDS.
- Published
- 2018
69. Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters
- Author
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Aurélien Schrapp, Sylvie Daliphard, Agnès Lahary, and Victor Bobée
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Male ,Reticulocytes ,Anemia ,Clinical Biochemistry ,Pyruvate Kinase ,Blood count ,Erythrocytes, Abnormal ,Spherocytosis, Hereditary ,Pyruvate Metabolism, Inborn Errors ,Hereditary spherocytosis ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Red Cell ,medicine.diagnostic_test ,business.industry ,Biochemistry (medical) ,Infant, Newborn ,Complete blood count ,Infant ,Hematology ,General Medicine ,Anemia, Hemolytic, Congenital Nonspherocytic ,medicine.disease ,Blood Cell Count ,030220 oncology & carcinogenesis ,Immunology ,Female ,Hemoglobin ,business ,Pyruvate kinase ,030215 immunology ,Pyruvate kinase deficiency - Abstract
INTRODUCTION Development of additional parameters for complete blood count has emerged in recent hematology analyzers, leading to many publications. However, few studies have been conducted on advanced RBC parameters and hemolytic anemias. We investigated the interest of Sysmex unique parameters, MicroR and HypoHe, as well as the immature fraction of reticulocytes (IRF) in combination with complete blood and reticulocyte count, for screening hereditary spherocytosis (HS) and pyruvate kinase deficiency. METHODS We analyzed 182 samples using Sysmex XE-5000 analyzers from a cohort of red cell disorder patients from the Rouen University Hospital. These included 47 HS, 17 pyruvate kinase deficiencies, sickle cell diseases and trait, β-thalassemia minor, iron deficiencies, and 489 samples from a routine group. RESULTS Combining five parameters (hemoglobin level, reticulocyte count, IRF, MicroR, and %HypoHe), we developed a specific screening tool for HS allowing a sensitivity of 100% and a specificity of 92.1% and a specific screening tool for pyruvate kinase deficiencies allowing a sensitivity of 100% and a specificity of 96.5%. These parameters were also found accurate in infants and in HS without anemia. CONCLUSION We propose a costless, easy-to-use, and efficient approach to detect HS and pyruvate kinase deficiencies using Sysmex analyzers. These screening tools may help diagnosis of these disorders, help prevent complications, and result in a better management of these patients.
- Published
- 2018
70. Chapitre 4. Carnet de notes en contextes
- Author
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Dominique Lahary and Aline Goussard
- Published
- 2018
71. Chapitre 3. Solubilités du bibliothécaire
- Author
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Dominique Lahary and Véronique Mesguich
- Published
- 2018
72. An Additional Case of Hb Saint Nazaire [β103(G5)Phe→Ile; HBB: c.310T>A] Leading to Moderate Erythrocytosis in a French Family
- Author
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Agnès Lahary, Valéry Brunel, Philippe Joly, Victor Bobée, and Guillaume Feugray
- Subjects
Proband ,business.industry ,Isoelectric focusing ,Biochemistry (medical) ,Clinical Biochemistry ,Blood count ,Hematology ,medicine.disease ,Molecular biology ,Hemoglobinopathy ,High oxygen ,Hb Saint Nazaire ,Medicine ,Hemoglobin ,business ,Genetics (clinical) ,Heterozygous mutation - Abstract
We report two members of a French family who are carriers of a rare hemoglobin (Hb) variant leading to erythrocytosis: Hb Saint Nazaire [β103(G5)Phe→Ile; HBB: c.310T>A]. The proband is a 38-year-old woman referred to our institution for a moderate but persistent polycythemia without any clinical consequence. As her mother had a similar blood count, a diagnosis of a Hb variant with high oxygen affinity was proposed. The variant was difficult to detect by capillary electrophoresis (CE) and not distinguishable by high performance liquid chromatography (HPLC) and isoelectric focusing. Finally, a heterozygous mutation on the HBB gene corresponding to Hb Saint Nazaire was identified. This case report illustrates that this rare cause of erythrocytosis can be easily under or misdiagnosed unless several Hb separation techniques are used.
- Published
- 2019
73. PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells
- Author
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Caulier, Alexis, primary, Jankovsky, Nicolas, additional, Demont, Yohann, additional, Ouled-Haddou, Hakim, additional, Demagny, Julien, additional, Guitton, Corinne, additional, Merlusca, Lavinia, additional, Lebon, Delphine, additional, Vong, Pascal, additional, Aubry, Aurélien, additional, Lahary, Agnès, additional, Rose, Christian, additional, Gréaume, Sandrine, additional, Cardon, Emilie, additional, Platon, Jessica, additional, Ouadid-Ahidouch, Halima, additional, Rochette, Jacques, additional, Marolleau, Jean-Pierre, additional, Picard, Véronique, additional, and Garçon, Loïc, additional
- Published
- 2019
- Full Text
- View/download PDF
74. Clinical and biological features in PIEZO1-hereditary xerocytosis and Gardos channelopathy: a retrospective series of 126 patients
- Author
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Picard, Véronique, primary, Guitton, Corinne, additional, Thuret, Isabelle, additional, Rose, Christian, additional, Bendelac, Laurence, additional, Ghazal, Kaldoun, additional, Aguilar-Martinez, Patricia, additional, Badens, Catherine, additional, Barro, Claire, additional, Bénéteau, Claire, additional, Berger, Claire, additional, Cathébras, Pascal, additional, Deconinck, Eric, additional, Delaunay, Jacques, additional, Durand, Jean-Marc, additional, Firah, Nadia, additional, Galactéros, Frédéric, additional, Godeau, Bertrand, additional, Jaïs, Xavier, additional, de Jaureguiberry, Jean-Pierre, additional, Le Stradic, Camille, additional, Lifermann, François, additional, Maffre, Robert, additional, Morin, Gilles, additional, Perrin, Julien, additional, Proulle, Valérie, additional, Ruivard, Marc, additional, Toutain, Fabienne, additional, Lahary, Agnès, additional, and Garçon, Loïc, additional
- Published
- 2019
- Full Text
- View/download PDF
75. An Additional Case of Hb Saint Nazaire [β103(G5)Phe→Ile; HBB: c.310T>A] Leading to Moderate Erythrocytosis in a French Family
- Author
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Bobée, Victor, primary, Feugray, Guillaume, additional, Brunel, Valéry, additional, Joly, Philippe, additional, and Lahary, Agnès, additional
- Published
- 2019
- Full Text
- View/download PDF
76. Haemoglobin J-Baltimore can be detected by HbA1c electropherogram but with underestimated HbA1c value
- Author
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Abdeslam Chagraoui, Valéry Brunel, Christian Thuillez, and Agnčs Lahary
- Subjects
Haemoglobin J-Baltimore ,Adult ,medicine.medical_specialty ,haemoglobin J-Baltimore ,endocrine system diseases ,Clinical Biochemistry ,capillary electrophoresis ,030209 endocrinology & metabolism ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Capillary electrophoresis ,Pregnancy ,Internal medicine ,Diabetes mellitus ,medicine ,glycated haemoglobin ,Humans ,In patient ,Glycated haemoglobin ,in-Brief ,Glycated Hemoglobin ,Hemoglobin J ,business.industry ,Biochemistry (medical) ,nutritional and metabolic diseases ,Electrophoresis, Capillary ,medicine.disease ,Gestational diabetes ,Electropherogram ,Diabetes, Gestational ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Glycated haemoglobin (HbA(1c)) is considered the gold standard for assessing diabetes compensation and treatment. In addition, fortuitous detection of haemoglobin variants during HbA1c measurement is not rare. Recently, two publications reported different conclusions on accuracy of HbA(1c) value using capillary electrophoresis method in presence of haemoglobin J-Baltimore (HbJ). Here we describe the fortuitous detection of unknown HbJ using capillary electrophoresis for measurement of HbA(1c). A patient followed for gestational diabetes in our laboratory presented unknown haemoglobin on Capillarys 2 Flex Piercing analyser which was identified as HbJ. HbJ is not associated with haematological abnormalities. High Performance Liquid Chromatography methods are known to possibly underestimate HbA(1c) value in the presence of this variant. This variant and its glycated form are clearly distinguished on electropherogram but HbJ was responsible for underestimating the true area of HbA(1c). Capillary electrophoresis is a good method for detecting HbJ but does not seem suitable for evaluation of HbA(1C) value in patients in presence of HbJ variant.
- Published
- 2016
77. 1. Communiquer grâce au lobbying : l’interassociation des bibliothécaires et des documentalistes (IABD)
- Author
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Lahary, Dominique
- Subjects
journalistes ,bibliothèques ,communication ,LAN025000 ,Library, Information & Communication sciences ,GL ,bibliothécaires ,bibliothéconomie - Abstract
Progressivement, à partir de 2003, s’est formé en France un regroupement d’associations professionnelles qui a conquis sa légitimité auprès des pouvoirs publics et des autres professions du livre et a à son actif des résultats législatifs incontestables. Cela mérite une narration, mais aussi et surtout une tentative d’analyse. LE RÉCIT Le 12 novembre 2003, sur proposition du ministre de la Culture Jean-Jacques Aillagon, le gouvernement de Jean-Pierre Raffarin adopta le projet de loi Dadvsi (D...
- Published
- 2017
78. Mener l'enquête
- Author
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Alarcon, Nicolas, Evans, Christophe, Gaudet, Françoise, Kratz, Isabelle, Lahary, Dominique, Leport, Véronique, Michel, Béatrice, Poissenot, Claude, Ripon, Romuald, Roselli, Mariangela, Rouillard, Dominique, Roussignol, Diane, and Evans, Christophe
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collecte de données ,bibliothèques ,LAN025000 ,public ,enquête ,Library, Information & Communication sciences ,GL - Abstract
Enquêter sur la fréquentation, les usages ou l'image des bibliothèques requiert des collectes de données variées, fiables, concertées. Pour ce faire, les professionnels des bibliothèques doivent connaître les spécificités du domaine et les processus généraux de la méthodologie des enquêtes. Qu’elle soit confiée à un prestataire extérieur ou réalisée en interne avec les moyens du bord, l'enquête de publics ne s'improvise pas. Elle suppose en effet, en plus d’une phase de préparation minutieuse, le respect d'une démarche rigoureuse. C’est ce dont rend compte ce guide en présentant de façon détaillée et pratique les étapes qui jalonnent le déroulement des études de publics, selon les trois temps de l’enquête : sa préparation, sa réalisation et l’exploitation-communication de ses résultats. Conçu tel un recueil de bonnes pratiques, l’ouvrage s’attache à fournir des éléments méthodologiques précis complétés par des comptes rendus critiques de travaux pilotés ou réalisés par des bibliothécaires aussi bien en bibliothèques universitaires qu’au sein de médiathèques de lecture publique. Coordonné par Christophe Evans, chargé d'études en sociologie au service Études et Recherche de la Bibliothèque publique d’information, et écrit par des experts rodés à l’exercice de l’enquête de publics, l’ouvrage traite aussi des aspects financiers, juridiques et des conséquences des enquêtes sur la politique générale des établissements.
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- 2017
79. Communiquer !
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Accart, Jean-Philippe, Appel, Violaine, Bieri, Susanne, Boulanger, Hélène, Carrier, Céline, Courrier, Serge, Desormeaux, Didier, Granger, Sabrina, Lacote-Gabrysiak, Lylette, Lahary, Dominique, Laroux, Marie-Noëlle, Le Calonec, Marie, Maumet, Luc, McAdam, Daisy, Poissenot, Claude, Ramonatxo, Ophélie, Revelin, Gaël, Sonnier, Corinne, Vidal, Jean-Marc, Yeomans, Joanne, and Accart, Jean-Philippe
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journalistes ,bibliothèques ,communication ,LAN025000 ,Library, Information & Communication sciences ,GL ,bibliothécaires ,bibliothéconomie - Abstract
L'enjeu de la communication en direction des élus, des décideurs, mais aussi des journalistes, est devenu vital pour les bibliothèques : il s'agit de donner à voir aux tutelles leurs activités, de rendre intelligible leur stratégie de développement, de construire une image institutionnelle forte. De quels moyens dispose la bibliothèque pour faire la preuve du bienfondé de son existence ? Comment communiquer en direction d'un élu municipal ou régional, d'un responsable politique de la bibliothèque ? Que peut apporter une bonne collaboration avec des journalistes, avec les partenaires naturels ou hiérarchiques au sein de l'université ou de la collectivité territoriale ? Comment utiliser à bon escient les méthodes du lobbying et du marketing, ou l'emploi des réseaux sociaux ? Voilà quelques-unes des questions abordées ici. Une quinzaine d'auteurs d'horizons divers (des sociologues, des enseignants, des journalistes, des bibliothécaires, des responsables de communication…) nous font part de leurs propres expériences, donnent des conseils méthodologiques et des outils fort utiles, en proposant de nombreux exemples et des mises en situation. Auteur de plusieurs ouvrages dans le domaine de la documentation et des sciences de l'information, Jean-Philippe Accart est actuellement directeur des bibliothèques de la Faculté des sciences de l'Université de Genève.
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- 2017
80. Cardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome
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Amandine Baptiste, Thibaud Lefebvre, Olivier Ernst, Emmanuelle Chauzit, Jean-Pierre Vannier, Agnès Guerci-Bresler, Christian Rose, Zoubida Karim, Hervé Puy, Aspasia Stamatoullas, Mariane De Montalembert, Valentine Brousse, Krimo Bouabdallah, Mohamed Touati, C. Dumesnil, Agnès Lahary, Marina Cavazzana, Caroline Elie, Jean-Antoine Ribeil, Service de pédiatrie générale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Centre de Référence de la Drépanocytose-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cytokines, hématopoïèse et réponse immune (CHRI), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de pédiatrie générale [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Service d'Hématologie Clinique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service d'Hématologie, Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Micro-Environnement et Régulation Cellulaire Intégrée (MERCI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Rouen, Normandie Université (NU), Hôpital Charles Nicolle [Rouen], Service d'Hématologie biologique [CHU Limoges], CHU Limoges, Hôpital Haut-Lévêque, Université Sciences et Technologies - Bordeaux 1-CHU Bordeaux [Bordeaux], Département de Biothérapie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], CHU Bordeaux [Bordeaux], Hôpital Cochin [AP-HP], Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'informatique médicale et biostatistiques [CHU Necker], Radiologie interventionnelle, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'hématologie, Hôpital Saint-Vincent-de-Paul, TAN, Yossan-Var, Université Sciences et Technologies - Bordeaux 1 (UB)-CHU Bordeaux [Bordeaux], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre de Référence de la Drépanocytose, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Subjects
Male ,Blood transfusion ,Physiology ,Thalassemia ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Gastroenterology ,Physical Chemistry ,Biochemistry ,Diagnostic Radiology ,0302 clinical medicine ,hemic and lymphatic diseases ,Medicine and Health Sciences ,Erythropoiesis ,10. No inequality ,Child ,lcsh:Science ,Multidisciplinary ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,biology ,Chelation ,Radiology and Imaging ,Heart ,Hematology ,Middle Aged ,Magnetic Resonance Imaging ,Sickle cell anemia ,Clinical Laboratory Sciences ,3. Good health ,[SDV] Life Sciences [q-bio] ,Chemistry ,Genetic Diseases ,030220 oncology & carcinogenesis ,Physical Sciences ,Female ,Anatomy ,Research Article ,Adult ,medicine.medical_specialty ,Iron Overload ,Adolescent ,Anemia ,Imaging Techniques ,Iron ,Anemia, Sickle Cell ,Research and Analysis Methods ,Iron Chelating Agents ,03 medical and health sciences ,Autosomal Recessive Diseases ,Hepcidin ,Diagnostic Medicine ,Internal medicine ,medicine ,Humans ,Blood Transfusion ,Clinical Genetics ,Ferritin ,Sickle Cell Disease ,Chemical Bonding ,business.industry ,Transfusion Medicine ,Myelodysplastic syndromes ,Myocardium ,lcsh:R ,Biology and Life Sciences ,Proteins ,Protein Complexes ,medicine.disease ,Hematopoiesis ,Hemoglobinopathies ,Myelodysplastic Syndromes ,biology.protein ,Cardiovascular Anatomy ,lcsh:Q ,business ,Physiological Processes ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
The risk and clinical significance of cardiac iron overload due to chronic transfusion varies with the underlying disease. Cardiac iron overload shortens the life expectancy of patients with thalassemia, whereas its effect is unclear in those with myelodysplastic syndromes (MDS). In patients with sickle cell anemia (SCA), iron does not seem to deposit quickly in the heart. Our primary objective was to assess through a multicentric study the prevalence of cardiac iron overload, defined as a cardiovascular magnetic resonance T2*8 ECs in the past year, and age older than 6 years. We included from 9 centers 20 patients with thalassemia, 41 with SCA, and 25 with MDS in 2012-2014. Erythrocytapharesis did not consistently prevent iron overload in patients with SCA. Cardiac iron overload was found in 3 (15%) patients with thalassemia, none with SCA, and 4 (16%) with MDS. The liver iron content (LIC) ranged from 10.4 to 15.2 mg/g dry weight, with no significant differences across groups (P = 0.29). Abnormal T2* was not significantly associated with any of the measures of transfusion or chelation. Ferritin levels showed a strong association with LIC. Non-transferrin-bound iron was high in the thalassemia and MDS groups but low in the SCA group (P
- Published
- 2017
81. HEREDITARY XEROCYTOSIS: CLINICAL AND BIOLOGICAL PRESENTATION AT DIAGNOSIS IN A RETROSPECTIVE SERIES OF 103 PATIENTS
- Author
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Picard, V., Guitton, C., Lahary, A., Martinez, P. Aguilar, Ruivard, M., Rose, C., Perrin, J., Barro, C., Lifermann, F., Jaureguiberry, J. -P., Deconinck, E., Beneteau, C., Lefebvre, T., Toutain, F., Le Coz, M. -F., Berger, C., Proulle, V., Beris, P., Godeau, B., Very, C., Garcon, Loic, Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), CHU Clermont-Ferrand, SIGMA Clermont, Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre National de la Recherche Scientifique (CNRS), Université catholique de Lille (UCL), Oncologie médicale [Hôpital Saint Vincent de Paul, Lille], Hôpital Saint-Vincent de Paul, Service de Gynécologie et Obstétrique [Marseille], Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Laboratoire d'Hématologie, CHU Grenoble, Centre Hospitalier de Dax, Service d'Hématologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CHU Pontchaillou [Rennes], CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), and DESSAIVRE, Louise
- Subjects
[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,parasitic diseases ,education ,social sciences ,health care economics and organizations ,geographic locations - Abstract
22nd Congress of the European-Hematology-Association, Madrid, SPAIN, JUN 22-25, 2017; International audience
- Published
- 2017
82. An overview of libraries in France
- Author
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Danièle Verdy, Grégor Blot-Julienne, Anne Verneuil, Thierry Claerr, Marie-Noëlle Andissac, Amandine Jacquet, Dominique Lahary, and Frédéric Blin
- Subjects
Documentation ,Political science ,Library science ,Professional association ,Library and Information Sciences ,Permission - Abstract
The paper presents an overview of the various types of libraries in France, including public libraries, academic and research libraries, other types of libraries, documentation, France’s library policy and the library staff and professional association environment The paper is based on a chapter from Les bibliothèques en Europe, projets, perspectives, (Libraries in Europe, Projects and Prospects) by Frederic Blin and Thierry Claerr, Paris, Editions du Cercle de la Librairie, 2013, with kind permission of the publisher and authors.
- Published
- 2014
83. Anémie hémolytique chez un nouveau-né après prise maternelle de nitrofurantoïne en fin de grossesse
- Author
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Bruel, H., Guillemant, V., Saladin-Thiron, C., Chabrolle, J.P., Lahary, A., and Poinsot, J.
- Published
- 2000
- Full Text
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84. Diagnostic d'une maladie de Wilson devant une anémie hémolytique.
- Author
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Feugray, Guillaume, Guillerme, Jennifer, Fraissinet, François, Brunel, Valéry, Chagraoui, Abdeslam, Dumant-Forest, Clémentine, and Lahary, Agnès
- Published
- 2020
- Full Text
- View/download PDF
85. Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters
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Bobée, Victor, primary, Daliphard, Sylvie, additional, Schrapp, Aurélien, additional, and Lahary, Agnès, additional
- Published
- 2018
- Full Text
- View/download PDF
86. La lecture publique en France
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Lahary, Dominique, primary
- Published
- 2018
- Full Text
- View/download PDF
87. Les associations de bibliothécaires et de documentalistes et d’archivistes en France
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Lahary, Dominique, primary
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- 2018
- Full Text
- View/download PDF
88. Computational simulations determining disulfonic stilbene derivative bioavailability within human serum albumin
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Jaunet-Lahary, Titouan, primary, Vercauteren, Daniel P., additional, Fleury, Fabrice, additional, and Laurent, Adèle D., additional
- Published
- 2018
- Full Text
- View/download PDF
89. In situ NMR spectroelectrochemistry for the structure elucidation of unstable intermediate metabolites
- Author
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Serge Akoka, Ugo Bussy, Véronique Ferchaud-Roucher, Titouan Jaunet-Lahary, Michel Krempf, Mohammed Boujtita, Patrick Giraudeau, Illa Tea, and Virginie Silvestre
- Subjects
In situ ,Magnetic Resonance Spectroscopy ,Molecular Structure ,Imine ,Reactive intermediate ,Phenacetin ,Nuclear magnetic resonance spectroscopy ,Analgesics, Non-Narcotic ,Biochemistry ,Analytical Chemistry ,Quinone ,chemistry.chemical_compound ,Drug Stability ,chemistry ,Computational chemistry ,Proton NMR ,Organic chemistry ,Molecule ,Oxidation-Reduction ,Two-dimensional nuclear magnetic resonance spectroscopy - Abstract
In situ NMR spectroelectrochemistry is presented in this study as a useful hybrid technique for the chemical structure elucidation of unstable intermediate species. An experimental setting was designed to follow the reaction in real time during the experimental electrochemical process. The analysis of (1)H NMR spectra recorded in situ permitted us (1) to elucidate the reaction pathway of the electrochemical oxidation of phenacetin and (2) to reveal the quinone imine as a reactive intermediate species without using any trapping reaction. Phenacetin has been considered as hepatotoxic at high therapeutic amounts, which is why it was chosen as a model to prove the applicability of the analytical method. The use of 1D and 2D NMR experiments led to the elucidation of the major species produced from the oxidation process. We demonstrated that in situ NMR spectroelectrochemistry constitutes a fast way for monitoring unstable quinone imines and elucidating their chemical structures.
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- 2013
90. Discours d’ouverture
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Christophe Pavlidès, Bruckman Denis, Jean-François Jacques, Daniel Renoult, Christophe Evans, Marie-Anne Toledano, Romuald Ripon, Jean-Noël Jeanneney, Olivier Chourrot, Lahary Dominique, Yves Alix, Alain Lefebvre, and Bernadette Seibel
- Published
- 2016
91. Bibliothèque et concurrence : par quel(s) bout(s) prendre la question ?
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Dominique Lahary
- Published
- 2016
92. Avertissement
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Yves Alix, Bruckman Denis, Olivier Chourrot, Christophe Evans, Jean-François Jacques, Lahary Dominique, Alain Lefebvre, Daniel Renoult, Romuald Ripon, Bernadette Seibel, Jean-Noël Jeanneney, Christophe Pavlidès, and Marie-Anne Toledano
- Published
- 2016
93. Exploring the Solvatochromism of Betaine 30 with Ab Initio Tools: From Accurate Gas-Phase Calculations to Implicit and Explicit Solvation Models
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Christian Laurence, Šimon Budzák, Titouan Jaunet-Lahary, Miroslav Medved, Denis Jacquemin, Adèle D. Laurent, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Structure et Réactivité des Systèmes Moléculaires Complexes (SRSMC), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Matej Bel University (UMB)
- Subjects
Models, Molecular ,Light ,Implicit solvation ,Ab initio ,Pyridinium Compounds ,010402 general chemistry ,01 natural sciences ,Catalysis ,Physical Phenomena ,Computational chemistry ,0103 physical sciences ,Coloring Agents ,ComputingMilieux_MISCELLANEOUS ,010304 chemical physics ,Molecular Structure ,Chemistry ,Organic Chemistry ,Solvatochromism ,Solvation ,Hydrogen Bonding ,General Chemistry ,0104 chemical sciences ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,Moment (mathematics) ,Dipole ,Spectrometry, Fluorescence ,Solvents ,Quantum Theory ,Thermodynamics ,Density functional theory ,Atomic physics ,Excitation - Abstract
Betaine 30 is known for the extraordinary solvatochromism of its visible absorption band that goes from λ=882 nm in tetrachloromethane to λ=453 nm in water (Δλ=-429 nm). This large blueshift partly originates from a dramatic decrease of the dipole moment upon excitation. Despite several decades of research, experimental works still disagree on the exact value of the excess dipole moment, the orientation of the dipole moment of the excited-state, the role and amplitude of the change of the polarisability upon excitation as well as on the gas-phase excitation energy. In this work, we present an in-depth theoretical investigation. First, we carefully tested several levels of theory on the model system and next calculated the electric properties of betaine 30 at the CC2 level. Our best estimates are Δμ=-7 D for the excess dipole moment, that is, a significant decrease but no change of direction, a Δα value of -120 a.u. and a gas-phase vertical excitation energy of 1.127 eV. The implicit solvation models are able to reproduce the experimental trends, with large correlation coefficients for non-hydrogen-bond-donating solvents, the smallest root-mean-square deviation error being reached with the vertical excitation model (VEM). The explicit effective fragment potential method combined with time-dependent density functional theory (TD-DFT) in a QM/MM framework provides accurate estimates for hydrogen-bond-donating solvents, whereas the addition of a dispersion correction is needed to restore the correct solvatochromic direction in tetrachloromethane.
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- 2016
94. Hémogramme automatisé du nouveau-né avec anomalies des histogrammes des plaquettes et des érythrocytes: penser à la Pyropoïkilocytose Héréditaire
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Bobée, Victor, Villeon, Gaëlle De La, Daliphard, Sylvie, Picard, Véronique, Lenormand, Bernard, and Lahary, Agnès
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- 2016
- Full Text
- View/download PDF
95. Cardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome
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de Montalembert, Mariane, primary, Ribeil, Jean-Antoine, additional, Brousse, Valentine, additional, Guerci-Bresler, Agnes, additional, Stamatoullas, Aspasia, additional, Vannier, Jean-Pierre, additional, Dumesnil, Cécile, additional, Lahary, Agnès, additional, Touati, Mohamed, additional, Bouabdallah, Krimo, additional, Cavazzana, Marina, additional, Chauzit, Emmanuelle, additional, Baptiste, Amandine, additional, Lefebvre, Thibaud, additional, Puy, Hervé, additional, Elie, Caroline, additional, Karim, Zoubida, additional, Ernst, Olivier, additional, and Rose, Christian, additional
- Published
- 2017
- Full Text
- View/download PDF
96. Exploring the Solvatochromism of Betaine 30 with Ab Initio Tools: From Accurate Gas‐Phase Calculations to Implicit and Explicit Solvation Models
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Budzák, Šimon, primary, Jaunet‐Lahary, Titouan, additional, Laurent, Adèle D., additional, Laurence, Christian, additional, Medved', Miroslav, additional, and Jacquemin, Denis, additional
- Published
- 2017
- Full Text
- View/download PDF
97. Dissymmetric Molecular Tweezers in Host–Guest Complexes: Internal or External Complexation?
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Jean-Yves Le Questel, Denis Jacquemin, Jérôme Graton, Jean-François Cupif, Loïc Toupet, Philippe Uriac, Titouan Jaunet-Lahary, Béatrice Legouin, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique de Rennes (IPR), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), 278845, European Research Council, 278845, Région des Pays de la Loire, Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
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[PHYS]Physics [physics] ,chemistry.chemical_compound ,General Energy ,Chemistry ,Stereochemistry ,Usnic acid ,[CHIM]Chemical Sciences ,Physical and Theoretical Chemistry ,Phenanthrene ,Molecular tweezers ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
International audience; The synthesis of two unprecedented series of dissymmetric molecular tweezers, with usnic acid, phenanthrene, or substituted naphthalimide arms as pincers, is described. Their association ability with the 2,4,7-trinitrofluorenone guest molecule has been quantified through NMR experiments in CD2Cl2 solution. Density Functional Theory calculations, including dispersion terms, have been carried out and rationalize both the conformational and the complexation mode behaviors of these new tweezers. With a naphthalimide and an usnic acid arms, the U-tweezer series indeed appears to behave as molecular tweezers. Conversely, in the P-tweezer series, involving a naphthalimide and a phenanthrene arm, the selected theoretical approach indicates that external complexes are more stabilized than the internal tweezed structures, corroborating experimental evidence of qualitatively different behaviors of the two series of tweezers.
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- 2015
98. Designing Efficient Azobenzene and Azothiophene Nonlinear Optical Photochromes
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Agisilaos Chantzis, Titouan Jaunet-Lahary, Denis Jacquemin, Adèle D. Laurent, Kathy J. Chen, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
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Implicit solvation ,Acceptor ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,chemistry.chemical_compound ,Photochromism ,General Energy ,Monomer ,chemistry ,Azobenzene ,Computational chemistry ,Molecule ,Density functional theory ,Physical and Theoretical Chemistry ,Cis–trans isomerism - Abstract
International audience; The present contribution constitutes an extensive density functional theory (DFT) investigation of the nonlinear optical (NLO) properties of a large number of molecules belonging to the azobenzene and azothiophene families of photochromic compounds which can act as NLO switches. Toward the design of systems simultaneously presenting both large total nonlinear response values, beta(tot), and large contrast, beta(ratio), between the cis and trans isomers, we have focused not only on the monomers but also on azobenzene dimers, the latter containing two N=N bonds along the molecular backbone. After it was established that the inclusion of implicit solvation is not important in drawing qualitative conclusions on the NLO switching ability for the investigated systems, gas-phase calculations have shown that for the asymmetric pushpull azobenzene and azothiophene candidates, the combination of strong donating groups such as NPh2, N(Ph-OMe)(2), and N(Ph-NMe2)(2) with the dicyanoethene group CH=C(C=N)(2) as an acceptor delivers large ?trans (150-217 x 10(-30) esu) and non-negligible beta(cis) (18-55 x 10(-30) esu) values as well as substantial contrast, beta(ratio) (3.9-8.7). For the investigated double azobenzenes, it is found that, with a careful choice of donor and acceptor groups, the contrast, beta(ratio), can be significantly increased compared to that of the monomers while maintaining large beta values that facilitate their detection with standard experimental techniques (e.g., electric-field-induced second-harmonic generation). Our results set the stage on which further theoretical and experimental studies can be based in the search for efficient and versatile NLO switches.
- Published
- 2014
99. Haemoglobin J-Baltimore can be detected by HbA1c electropherogram but with underestimated HbA1c value.
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Valéry Brunel, Agnes Lahary, Abdeslam Chagraoui, Christian Thuillez, Valéry Brunel, Agnes Lahary, Abdeslam Chagraoui, and Christian Thuillez
- Abstract
Glycated haemoglobin (HbA1c) is considered the gold standard for assessing diabetes compensation and treatment. In addition, fortuitous detection of haemoglobin variants during HbA1c measurement is not rare. Recently, two publications reported different conclusions on accuracy of HbA1c value using capillary electrophoresis method in presence of haemoglobin J-Baltimore (HbJ). Here we describe the fortuitous detection of unknown HbJ using capillary electrophoresis for measurement of HbA1c. A patient followed for gestational diabetes in our laboratory presented unknown haemoglobin on Capillarys 2 Flex Piercing analyser which was identified as HbJ. HbJ is not associated with haematological abnormalities. High Performance Liquid Chromatography methods are known to possibly underestimate HbA1c value in the presence of this variant. This variant and its glycated form are clearly distinguished on electropherogram but HbJ was responsible for underestimating the true area of HbA1c. Capillary electrophoresis is a good method for detecting HbJ but does not seem suitable for evaluation of HbA1C value in patients in presence of HbJ variant.
- Published
- 2016
100. Dose-dependent effect of dehydroepiandrosterone, but not of its sulphate ester, on angiogenesis
- Author
-
Etienne-Emile Baulieu, Loïc Vincent, Claudine Soria, Paule Opolon, Hong Li, Julia Varet, E. Legrand, Pezhman Mirshahi, Yvette Akwa, Jeannette Soria, Agnès Lahary, and Zohair Mishal
- Subjects
endocrine system ,medicine.medical_specialty ,Angiogenesis ,Dehydroepiandrosterone ,Angiogenesis Inhibitors ,Inflammation ,Biology ,chemistry.chemical_compound ,In vivo ,Internal medicine ,polycyclic compounds ,medicine ,Humans ,Glucose-6-phosphate dehydrogenase ,Cells, Cultured ,Pharmacology ,Dose-Response Relationship, Drug ,Dehydroepiandrosterone Sulfate ,Endothelial Cells ,In vitro ,Endothelial stem cell ,Endocrinology ,chemistry ,Ageing ,medicine.symptom ,human activities ,hormones, hormone substitutes, and hormone antagonists - Abstract
Although dehydroepiandrosterone (DHEA) is widely used in the elderly to prevent some adverse effects of ageing, possible deleterious side effects have not been fully assessed. We evaluated the direct actions of DHEA and DHEA sulphate on angiogenesis, a critical event in pathologies that are common in the elderly (cancer, atherosclerosis, inflammation… etc.). At physiological concentrations found in human plasma following DHEA therapy (1–50 nM), DHEA had no action on angiogenesis in vitro. In contrast, higher concentrations of DHEA (10–100 μM), which can be found in tissues after local administration or storage, inhibited in vitro endothelial cell proliferation (blockage in G2/M), migration and capillary tube formation and in vivo angiogenesis in the Matrigel plug assay. This inhibition might be due to a decreased glucose-6-phosphate dehydrogenase activity and to a modification of the tubulin network involved in cell proliferation and migration. The sulphate ester form of DHEA had no effect on angiogenesis.
- Published
- 2004
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