3,436 results on '"Laboratoire Réactions et Génie des Procédés ( LRGP )"'
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52. Impact of the size and degree of branching of alkanes on the rate rules approach: the case of isomerizations
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Citrangolo Destro, Fabiola, Fournet, René, Warth, Valérie, Glaude, Pierre-Alexandre, Sirjean, Baptiste, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and European Project: 101003318,BioSCOPE
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[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,rate rules ,Mechanical Engineering ,General Chemical Engineering ,[SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment ,Physical and Theoretical Chemistry ,kinetic model generation ,H-atom shifts ,theoretical chemistry - Abstract
International audience; The accurate and high-throughput generation of kinetic data for combustion detailed chemical kinetic models remains a challenge given the large size of these models. For large organic molecules, the majority of kinetic data of the kinetic models are estimated using quantitative structure activity relationships within reaction classes and reaction rate rules approaches. In this work, we question the limits of the rate rule approach for the isomerization reaction classes, using electronic structure calculations and reaction rate theories. Systematic calculations were performed to investigate the effect of the size and the degree of branching of alkyl radicals on the rate coefficients and their consequences on the rate rule approach. Our computed kinetic data show that when the size of alkyl group is increased, the rate coefficients remains close to each other. This allows the use of methyl as representative models of larger alkyl groups to investigate the influence of increasing the degree of branching. The computed rate coefficients for 1,3-and 1,4-H-atom shifts show that the increase of the branching level, with spectator methyl groups in the transition state cyclic structure can strongly increase the rate coefficients, up to several orders of magnitude. Consequently, a single rate rule is not feasible for any degree of branching of a reaction belonging to the same isomerization reaction class. As variation in rate coefficients are important, this would lead to an explosion of the number rate rules as a function of branching in 5-, 6-, and 7membered cyclic transition states. A new approach is demonstrated and proposed where model transition states are tabulated, and methyl groups are assumed as alkyl groups and all combinations of substitutions in the model TSs, for a given reaction class, are included in a table with associated ab initio rate coefficients. The automation of the construction of such tables is possible and could be an interesting high-throughput / high-accuracy alternative to on-the-fly ab initio calculations of kinetic parameters.
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- 2022
53. Hybrid Flow Bioreactor with All Catalysts Immobilized for Enzymatic Electrosynthesis
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Wassim El Housseini, François Lapicque, Steve Pontvianne, Neus Vilà, Ievgen Mazurenko, Alain Walcarius, Mathieu Etienne, Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement (LCPME), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Bioénergétique et Ingénierie des Protéines (BIP ), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), CNRS, and European Regional Development Fund (ERDF)
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Bioconversion ,Gas diffusion electrode ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,β-nicotinamide adenine dinucleotide ,Electrochemistry ,[CHIM]Chemical Sciences ,Electrochemical regeneration ,[CHIM.CATA]Chemical Sciences/Catalysis ,Catalysis ,Redox flow - Abstract
International audience; The electrochemical regeneration of the NADH cofactor was realized in a hybrid flow reactor coupling fuel cell technology and redox flow device, paying attention to the robust immobilization of all catalysts. The rhodium catalyst Rh(Cp∗)(bpy)Cl+ was covalently immobilized on a MWCNT layer and the association with the gas diffusion electrode was carefully optimized. High stability and activity of the electrochemical system were assessed by cyclic voltammetry and amperometry in the flow reactor. Afterwards, the optimal cofactor regeneration was applied to NADH-dependent biosynthesis using immobilized lactate dehydrogenase for the conversion of pyruvate to lactate in the flow cell in the presence of cofactor concentration as low as 10 μM. 79 % faradaic efficiency was achieved and remarkable total turnover number (TTN) were reached: 2500, 18000, and 180000, for the NADH cofactor, the Rh complex and the LDH enzyme, respectively.
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- 2022
54. Recovery of nickel from strongly acidic bio-ore leachate using a bispicolylamine-based chelating resin
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Bastien Jally, Mathilde François, Morgane Kessler, Baptiste Laubie, Marie-Odile Simonnot, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and European Project: 652615,H2020,H2020-ISIB-2014-1,FACCE SURPLUS(2015)
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Chelating resin ,agromining ,hydrometallurgy ,Filtration and Separation ,phytomining ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,column experiments ,Analytical Chemistry ,nickel recovery - Abstract
International audience; Given the increasing demand for nickel (Ni) in the Li-ion battery industry, the agromining chain of processes, based on phytomining of Ni combined with hydrometallurgy, has the potential to form an important source of Ni. Currently, plants grown on Ni-rich soils (in this case Odontarrhena chalcidica), having hyperaccumulated Ni, are ashed, and the Ni is transferred from ash to solution by sulfuric acid leaching. This work focuses on the recovery of Ni-sulfate from this strongly acidic leachate that contains many cations. For this purpose, a bispicolylamine-based chelating resin (Dowex M4195) was tested to better understand the functioning of this resin under these conditions. Column experiments were performed with model synthetic solutions containing Ni and Na-sulfate at pH 2. A set of reactions has been formulated to describe the interactions involved and used in a model combining transport in porous media and chemical reactions at equilibrium. Excellent agreement between the experimental and the calculated breakthrough curves were obtained by adjusting only two parameters. The set of reactions and parameters allowed to fit with sufficient accuracy the breakthrough curves obtained from an ash leachate of the hyperaccumulator plant O. chalcidica. A better understanding of the use of the Dowex M4195 resin for the extraction of Ni from a strong acid multicomponent solution has been achieved, and this separation has been shown to be promising for the recovery of Ni extracted from hyperaccumulator plant bio-ores as part of the agromining process.
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- 2022
55. Bifunctional polypyridyl-Ru(II) complex grafted onto gadolinium-based nanoparticles for MR-imaging and Q1 photodynamic therapy
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Truillet, Charles, Lux, François, Moreau, Juliette, Four, Mickael, Sancey, Lucie, Chevreux, Sylviane, Bœuf, Gaëlle, Perriat, Pascal, Frochot, Céline, Antoine, Rodolphe, Dugourd, Philippe, Portefaix, Christophe, Hoeffel, Christine, Barberi-Heyob, Muriel, Terryn, Christine, van Gulick, Laurence, Lemercier, Gilles, Tillement, Olivier, Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon, Laboratoire de Chimie - UMR5182 ( LC ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Matériaux, ingénierie et science [Villeurbanne] ( MATEIS ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ) -Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Spectrométrie Ionique et Moléculaire ( LASIM ), Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims ( CHU Reims ), Centre de Recherche en Automatique de Nancy ( CRAN ), Plateforme en Imagerie Cellulaire et Tissulaire ( PICT ), Université de Reims Champagne-Ardenne ( URCA ) -SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ), Matrice extracellulaire et dynamique cellulaire - UMR 7369 ( MEDyC ), Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Reims (CHU Reims), Centre de Recherche en Automatique de Nancy (CRAN), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Plateforme en Imagerie Cellulaire et Tissulaire (PICT), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), and Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)
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[SDV.IB]Life Sciences [q-bio]/Bioengineering ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering - Abstract
International audience; The synthesis, optical properties and efficiency of new multifunctionnal nanoparticles as theranostic (fluorescence/MRI/PDT) agents are described. They are based on a polysiloxane network and surrounded by gadolinium(III) chelates and ruthenium(II) complexes. The size of the nanoparticles is maintained under 5 nanometres in order to permit their efficient elimination from the body. Their potential use as a theranostic agent (PDT/MRI) is described. The magnetic properties of the nanoparticles are studied by relaxometry (r1 = 9.21 mM-1.s-1 at 40 MHz; r2/r1 = 1.14) and the signal enhancement is validated by the acquisition of phantoms on a 3T MRI imager. The therapeutic potential for photodynamic therapy of the nanoparticles has been studied in vitro on HEK293 cells and an effective quantum yield of 0.33 for 1O2 production has been determined in deuterated water.
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- 2013
56. Bubble formation at an orifice: A multiscale investigation
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Nadia Mayoufi, Nicolas Dietrich, Huai Z. Li, Noël Midoux, Souhila Poncin, Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
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General Chemical Engineering ,Bubble ,µ-PIV ,02 engineering and technology ,[ CHIM ] Chemical Sciences ,Industrial and Manufacturing Engineering ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,Physics::Fluid Dynamics ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,020401 chemical engineering ,Phase (matter) ,Mass transfer ,Newtonian fluid ,0204 chemical engineering ,Physics ,Applied Mathematics ,General Chemistry ,Mechanics ,Velocimetry ,021001 nanoscience & nanotechnology ,flow measurements ,PIV ,Classical mechanics ,multiscale ,lateral flow ,Liquid bubble ,0210 nano-technology ,Shear flow ,Body orifice ,bubble formation - Abstract
International audience; The formation of gas bubbles in a liquid is of both academic and industrial interest, and sets the initial conditions for the hydrodynamics, heat and mass transfer as well as chemical reactions from a dispersed gaseous phase to the liquid phase in industrial processes. The literature on bubble formation from a single submerged orifice is large in both Newtonian and non-Newtonian fluids. Despite the numerous theoretical and experimental investigations, the mechanisms of bubble growth and detachment remain far from fully understood. The study of bubble formation at micro-scale and especially in the presence of a lateral liquid flow field is still very limited. This is the topic for consideration in the present paper. In particular, this study compares both qualitatively and quantitatively the formation of bubbles at micro- and macro-scales. A high-speed digital camera (up to 10,000 images s(-1)), a micro-Particle Image Velocimetry (mu-PIV) system and also a macro-PIV (PIV) were employed in this work, to measure the velocity flow field at micro- and macro-scales. At macro-scale, experiments were conducted in a square Altuglas column of 0.1 m filled with water or viscous Emkarox solutions using different orifice sizes and various gas flowrates. A rotating device above the orifice in the column was used to impose a shear flow on the forming bubble at the orifice. At micro-scale, different sizes of micro-reactors (600 and 1000 mu m) and different micro-devices were employed to compare the mechanism of bubble formation. A correlation based on dimensionless numbers was proposed to estimate the formed bubble volume at micro- and macro-scales in order to reveal the main factors governing the formation mechanisms.
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- 2013
57. Numerical simulation of the interactions between three equal-interval parallel bubbles rising in non-Newtonian fluids
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Youguang Ma, Chunying Zhu, Taotao Fu, Jingru Liu, Huai-Zhi Li, State Key Lab Chem Engn, Sch Chem Engn & Technol, Tianjin, Tianjin University, Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Tianjin University (TJU), Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
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Coalescence (physics) ,Physics ,Maximum bubble pressure method ,Applied Mathematics ,General Chemical Engineering ,Bubble ,Multiphase flow ,02 engineering and technology ,General Chemistry ,Mechanics ,021001 nanoscience & nanotechnology ,Breakup ,01 natural sciences ,[ CHIM ] Chemical Sciences ,Industrial and Manufacturing Engineering ,Non-Newtonian fluid ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,010305 fluids & plasmas ,Surface tension ,Physics::Fluid Dynamics ,0103 physical sciences ,Volume of fluid method ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,0210 nano-technology - Abstract
International audience; The motion and interactions of three equal-interval parallel bubbles in non-Newtonian fluids were numerically simulated by volume of fluid method (VOF), in which the continuous surface tension model and the power-law model were adopted to represent surface tension and rheological properties of non-Newtonian fluids, respectively. The computational method was validated by the comparison of the processes of coalescence of two in-line bubbles and rising of two parallel bubbles between experiment and simulation. This method was then applied to study the effect of initial bubble diameter, initial horizontal bubble interval and rheological properties of non-Newtonian fluids on lateral coalescence and rising of three parallel bubbles. The dimensionless critical horizontal interval of bubble coalescence was obtained under different physical property conditions. The critical horizontal interval of bubble coalescence decreases with the increase of initial bubble diameter and flow index of non-Newtonian fluids. When the initial horizontal bubble interval is less than the critical horizontal interval of bubble coalescence, three bubbles will coalesce into a bigger bubble. The coalescing bubble could breakup into two identical daughter bubbles when the initial bubble diameter was increased or the flow index of non-Newtonian fluids was decreased. Three parallel bubbles rising in non-Newtonian fluids will experience repulsive interactions once the initial horizontal bubble interval is greater than the critical horizontal interval of bubble coalescence, the horizontal bubble interval increased gradually owing to the repulsive effect, while the vertical distance between bubbles varied dramatically for spherical bubble and ellipsoidal bubble due to the differences of their flow field structures.
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- 2013
58. Real-time monitoring of photocytotoxicity in nanoparticles-based photodynamic therapy: a model-based approach
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Benachour, Hamanou, Bastogne, Thierry, Toussaint, Magali, Chemli, Yosra, Sève, Aymeric, Frochot, Céline, Lux, François, Tillement, Olivier, Vanderesse, Régis, Barberi-Heyob, Muriel, Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Biology, genetics and statistics (BIGS), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre Alexis Vautrin (CAV), Centre de Recherche en Automatique de Nancy ( CRAN ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Biology, genetics and statistics ( BIGS ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut Élie Cartan de Lorraine ( IECL ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Laboratoire de Chimie Physique Macromoléculaire ( LCPM ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Centre Alexis Vautrin ( CAV ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
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Time Factors ,Light ,Materials Science ,Cancer Treatment ,lcsh:Medicine ,Biostatistics ,Toxicology ,Models, Biological ,Cell Growth ,Engineering ,Computer Systems ,Cell Line, Tumor ,Molecular Cell Biology ,Cell Adhesion ,Statistical Signal Processing ,Nanotechnology ,Humans ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering ,lcsh:Science ,Biology ,Cell Proliferation ,Photosensitizing Agents ,Cell Death ,Systems Biology ,Statistics ,lcsh:R ,Computational Biology ,Cancers and Neoplasms ,Kinetics ,Oncology ,Photochemotherapy ,Signal Processing ,Bionanotechnology ,Multivariate Analysis ,Linear Models ,Medicine ,Nanoparticles ,lcsh:Q ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Cell Division ,Mathematics ,Research Article - Abstract
International audience; Nanoparticles are widely suggested as targeted drug-delivery systems. In photodynamic therapy (PDT), the use of multifunctional nanoparticles as photoactivatable drug carriers is a promising approach for improving treatment efficiency and selectivity. However, the conventional cytotoxicity assays are not well adapted to characterize nanoparticles cytotoxic effects and to discriminate early and late cell responses. In this work, we evaluated a real-time label-free cell analysis system as a tool to investigate in vitro cyto- and photocyto-toxicity of nanoparticles-based photosensitizers compared with classical metabolic assays. To do so, we introduced a dynamic approach based on real-time cell impedance monitoring and a mathematical model-based analysis to characterize the measured dynamic cell response. Analysis of real-time cell responses requires indeed new modeling approaches able to describe suited use of dynamic models. In a first step, a multivariate analysis of variance associated with a canonical analysis of the obtained normalized cell index (NCI) values allowed us to identify different relevant time periods following nanoparticles exposure. After light irradiation, we evidenced discriminant profiles of cell index (CI) kinetics in a concentration- and light dose-dependent manner. In a second step, we proposed a full factorial design of experiments associated with a mixed effect kinetic model of the CI time responses. The estimated model parameters led to a new characterization of the dynamic cell responses such as the magnitude and the time constant of the transient phase in response to the photo-induced dynamic effects. These parameters allowed us to characterize totally the in vitro photodynamic response according to nanoparticle-grafted photosensitizer concentration and light dose. They also let us estimate the strength of the synergic photodynamic effect. This dynamic approach based on statistical modeling furnishes new insights for in vitro characterization of nanoparticles-mediated effects on cell proliferation with or without light irradiation.
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- 2012
59. Visualization of mass transfer in mixing processes in high solid anaerobic digestion using Laser Induced Fluorescence (LIF) technique
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Xiaoming Peng, Fengping Hu, Yuying Hu, Souhila Poncin, Huai-Zhi Li, Shihao Zhang, Jing Wu, Xin Wang, Chuqiao Wang, Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
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Materials science ,020209 energy ,Mixing (process engineering) ,02 engineering and technology ,010501 environmental sciences ,Computational fluid dynamics ,01 natural sciences ,7. Clean energy ,Impeller ,Bioreactors ,Mass transfer ,0202 electrical engineering, electronic engineering, information engineering ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Anaerobiosis ,Diffusion (business) ,Laser-induced fluorescence ,Waste Management and Disposal ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences ,[SDE.IE]Environmental Sciences/Environmental Engineering ,business.industry ,Lasers ,Mechanics ,6. Clean water ,Particle image velocimetry ,Scientific method ,Hydrodynamics ,Rheology ,business - Abstract
High solid anaerobic digestion (HSAD) is a promising technology for the treatment of organic waste. Mixing process in HSAD is quite difficult with long mixing time, poor homogenization, significant short-circuiting and stagnant zones. However, the mass transfer in mixing process in HSAD has not been visualized due to the lack of a proper method. In this study, a novel approach for experimentally quantifying the mass transfer in HSAD’s mixing process was proposed in a mixing tank equipped with multistage impellers by means of the Laser Induced Fluorescence (LIF) technique. Flow field was investigated for better illustrating the mass transfer, thus Particle Image Velocimetry (PIV) and Computational Fluid Dynamics (CFD) technique were conducted for flow field measurement. The obtained results revealed that the feedstock tended to accumulate around the impeller in the HSAD system, especially near the 1st stage. The tracer diffused rapidly around the 1st impeller in t = 10 s, but the diffusion around the 2nd impeller was quite tough even after 4 h 08 min 23 s. And prolonging mixing time could not significantly improve the flow pattern along with the mixing. In this study, new insight was thrown into the visualization of the mass transfer in mixing process within a HSAD reactor. The visualization of mass transfer in the mixing process in HSAD could offer reference information to the study of the mixing process of HSAD even in full-scale.
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- 2021
60. A critical perspective on the implementation of the EU Council Seveso Directives in France, Germany, Italy and Spain
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André Laurent, Alexis Pey, Bruno Fabiano, Peter Gurtel, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Stahl Holding BV, Waalwijk, Netherlands, BGRCI, Heidelberg, Germany, and University of Genoa (UNIGE)
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Environmental Engineering ,Process (engineering) ,General Chemical Engineering ,media_common.quotation_subject ,Control (management) ,0211 other engineering and technologies ,Legislation ,02 engineering and technology ,010501 environmental sciences ,Public administration ,01 natural sciences ,Industrial Accident ,[SPI]Engineering Sciences [physics] ,Political science ,Member state ,Environmental Chemistry ,media_common.cataloged_instance ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Quality (business) ,LUP criteria ,European union ,Safety, Risk, Reliability and Quality ,Enforcement ,0105 earth and related environmental sciences ,media_common ,Implementation ,Inspection practices ,Land Use Planning criteria ,Seveso legislation ,021110 strategic, defence & security studies - Abstract
From 1982–2012, an important legislation, known as Seveso Directives I-II-III and amendments, was adopted in the European Union to regulate and prevent major industrial accident hazards. This European legislation was transposed, applied and implemented in each European Member State and after nearly forty years it is worthwhile to look back and also to look forward to key issues relevant to actual Seveso implementation. Authors of this paper are all members (retired or active) of the Loss Prevention Working Party of the European Federation of Chemical Engineering, which started in 1971. This article examines and compares, for the four EU Member States France, Germany, Italy and Spain, the structures and practices for the implementing of the European rules. Difficulties, variations in application and the quality of enforcement of this complex process are critically discussed, including proper analysis of worked examples. Finally, a particular attention is paid to the different ways in which the control and inspection practices of each of the Member States concerned are implemented.
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- 2021
61. Multifunctional peptide-conjugated hybrid silica nanoparticles for photodynamic therapy and MRI
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Hamanou Benachour, Imen Miladi, Olivier Tillement, Céline Frochot, Aymeric Sève, François Lux, Jordane Jasniewski, Thierry Bastogne, Muriel Barberi-Heyob, Claire Billotey, Régis Vanderesse, Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Biology, genetics and statistics (BIGS), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ingénierie des Biomolécules (LIBio), Université de Lorraine (UL), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre Alexis Vautrin (CAV), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Automatique de Nancy ( CRAN ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Biology, genetics and statistics ( BIGS ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut Élie Cartan de Lorraine ( IECL ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Chimie Physique Macromoléculaire ( LCPM ), Laboratoire d'Ingénierie des Biomolécules ( LIBio ), Université de Lorraine ( UL ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), and Centre Alexis Vautrin ( CAV )
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Gadolinium ,medicine.medical_treatment ,Brain tumor ,Medicine (miscellaneous) ,chemistry.chemical_element ,Photodynamic therapy ,Nanotechnology ,Peptide ,02 engineering and technology ,010402 general chemistry ,Targeted PDT ,01 natural sciences ,chemistry.chemical_compound ,medicine ,DOTA ,Photosensitizer ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,chemistry.chemical_classification ,business.industry ,021001 nanoscience & nanotechnology ,medicine.disease ,0104 chemical sciences ,3. Good health ,neuropilin-1 ,chemistry ,Cancer cell ,Chlorin ,Cancer research ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,functionalized theranostic nanoparticles ,0210 nano-technology ,business ,brain tumor ,Research Paper ,MRI - Abstract
International audience; Photodynamic therapy (PDT) is an emerging theranostic modality for various cancer as well as non-cancer diseases. Its efficiency is mainly based on a selective accumulation of PDT and imaging agents in tumor tissue. The vascular effect is widely accepted to play a major role in tumor eradication by PDT. To promote this vascular effect, we previously demonstrated the interest of using an active- targeting strategy targeting neuropilin-1 (NRP-1), mainly over-expressed by tumor angiogenic vessels. For an integrated vascular-targeted PDT with magnetic resonance imaging (MRI) of cancer, we developed multifunctional gadolinium-based nanoparticles consisting of a surface-localized tumor vasculature targeting NRP-1 peptide and polysiloxane nanoparticles with gadolinium chelated by DOTA derivatives on the surface and a chlorin as photosensitizer. The nanoparticles were surface-functionalized with hydrophilic DOTA chelates and also used as a scaffold for the targeting peptide grafting. In vitro investigations demonstrated the ability of multifunctional nanoparticles to preserve the photophysical properties of the encapsulated photosensitizer and to confer photosensitivity to MDA-MB-231 cancer cells related to photosensitizer concentration and light dose. Using binding test, we revealed the ability of peptide-functionalized nanoparticles to target NRP-1 recombinant protein. Importantly, after intravenous injection of the multifunctional nanoparticles in rats bearing intracranial U87 glioblastoma, a positive MRI contrast enhancement was specifically observed in tumor tissue. Real-time MRI analysis revealed the ability of the targeting peptide to confer specific intratumoral retention of the multifunctional nanoparticles.
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- 2012
62. Toxicity of carbon dioxide: A review
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Thierry Jo Molina, Mireille Régnier, Jacques Bonte, Adeline Guais, Gérard Brand, Georges Grevillot, Sam Dukan, Mélanie Karrer, Laurence Jacquot, Laurent Schwartz, Algorithms and Models for Integrative Biology (AMIB ), Laboratoire d'informatique de l'École polytechnique [Palaiseau] (LIX), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Laboratoire de chimie bactérienne (LCB), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biorébus, Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) ( NEURO ), Université de Franche-Comté ( UFC ) -Université Bourgogne Franche-Comté [COMUE] ( UBFC ), Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des Sciences du Génie Chimique ( LSGC ), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Laboratoire d'informatique de l'École polytechnique [Palaiseau] ( LIX ), Centre National de la Recherche Scientifique ( CNRS ) -École polytechnique ( X ), AP-HP Hôpital Raymond Poincaré [Garches], Biorebus, Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Franche-Comté (UFC), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [APHP], Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences du Génie Chimique (LSGC), Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Algorithms and Models for Integrative Biology ( AMIB ), École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ) -Laboratoire de Recherche en Informatique ( LRI ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -CentraleSupélec-Centre National de la Recherche Scientifique ( CNRS ) -Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -CentraleSupélec-Centre National de la Recherche Scientifique ( CNRS ) -Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique ( Inria ), Laboratoire de Neurosciences Intégratives et Cliniques - UFC ( NEURO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Laboratoire de chimie bactérienne ( LCB ), Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Hôpital Raymond Poincaré [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
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Central Nervous System ,MESH : Carcinogens ,[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition ,[ SDV.TOX ] Life Sciences [q-bio]/Toxicology ,Physiology ,010501 environmental sciences ,Toxicology ,Long term toxicity ,MESH: Reproduction ,MESH: Carbon Dioxide ,Cardiovascular System ,01 natural sciences ,Tobacco smoke ,MESH: Carcinogens ,Hypercapnia ,chemistry.chemical_compound ,MESH: Bicarbonates ,MESH: Animals ,[ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,Lung ,Acidosis ,0303 health sciences ,Inhalation ,MESH : Central Nervous System ,Reproduction ,MESH : Reproduction ,General Medicine ,[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,3. Good health ,MESH : Carbon Dioxide ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,Toxicity ,Carbon dioxide ,MESH: Acidosis, Respiratory ,medicine.symptom ,MESH : Lung ,MESH : Bicarbonates ,03 medical and health sciences ,MESH : Cardiovascular System ,[ INFO.INFO-BI ] Computer Science [cs]/Bioinformatics [q-bio.QM] ,medicine ,Animals ,Humans ,MESH: Central Nervous System ,MESH: Lung ,Carcinogen ,030304 developmental biology ,0105 earth and related environmental sciences ,Fetus ,MESH: Humans ,MESH : Hypercapnia ,business.industry ,MESH: Cardiovascular System ,MESH : Humans ,Carbon Dioxide ,MESH : Acidosis, Respiratory ,Bicarbonates ,chemistry ,MESH: Hypercapnia ,Carcinogens ,MESH : Animals ,Acidosis, Respiratory ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
Lien vers le texte intégral : http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21732636; International audience; The toxicity of carbon dioxide has been established for close to a century. A number of animal experiments have explored both acute and long-term toxicity with respect to the lungs, the cardiovascular system, and the bladder, showing inflammatory and possible carcinogenic effects. Carbon dioxide also induces multiple fetal malformations and probably reduces fertility in animals. The aim of the review is to recapitulate the physiological and metabolic mechanisms resulting from CO(2) inhalation. As smokers are exposed to a high level of carbon dioxide (13%) that is about 350 times the level in normal air, we propose the hypothesis that carbon dioxide plays a major role in the long term toxicity of tobacco smoke.
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- 2011
63. Design of a reactor operating in supercritical water conditions using CFD simulations. Examples of synthesized nanomaterials
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Mostapha Ariane, Frédéric Bernard, Hervé Muhr, Antoine Leybros, Frédéric Demoisson, Laboratoire Interdisciplinaire Carnot de Bourgogne ( LICB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), OSEO, Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
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Materials science ,CONTINUOUS HYDROTHERMAL SYNTHESIS ,General Chemical Engineering ,Nuclear engineering ,Oxide ,Nanotechnology ,02 engineering and technology ,Computational fluid dynamics ,010402 general chemistry ,7. Clean energy ,01 natural sciences ,MIXER ,Nanomaterials ,Crystallinity ,chemistry.chemical_compound ,NANOPOWDERS ,METAL-OXIDE NANOPARTICLES ,Nano-oxides ,Fluent ,PARTICLES ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Physical and Theoretical Chemistry ,High-resolution transmission electron microscopy ,Supercritical water ,business.industry ,[ SPI.GPROC ] Engineering Sciences [physics]/Chemical and Process Engineering ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,CFD simulations ,Supercritical fluid ,0104 chemical sciences ,Powder synthesis ,NANOCRYSTALS ,chemistry ,Scientific method ,0210 nano-technology ,business - Abstract
International audience; Direct information about fluids under supercritical water conditions is unfeasible due to the engineering restrictions at high pressure and high temperature. Numerical investigations based on computational fluid dynamics (CFD) calculations are widely used in order to get extensive information on the fluid behavior, particularly to help the design of a new reactor. This paper presents the numerical investigations performed on an original supercritical water device, especially in the level of the reactor. CFD calculations allow to design and optimize the present reactor described in this study. Currently, this process produces some nanometric oxide powders in continuous way with a production rate of 10-15g h(-1). Examples of synthesized nanomaterials are presented in order to prove the process efficiency. Crystalline ZrO(2) and TiO(2) were produced from a metallic salt and an organometallic as precursors, respectively. XRD and HRTEM analyses show nanosized particles with an uniform size distribution (
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- 2011
64. Particle synthesis by means of the thermal hydrolysis of mineral precursors
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Aymes , D., Ariane , Mostapha, Bernard , F., Muhr , Hervé, Demoisson , Frédéric, Laboratoire de Recherche sur la Réactivité des Solides ( LRRS ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Interdisciplinaire Carnot de Bourgogne ( LICB ), Laboratoire de Recherche sur la Réactivité des Solides (LRRS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), and Wild, Gabriel
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[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,[ SPI.GPROC ] Engineering Sciences [physics]/Chemical and Process Engineering - Published
- 2011
65. A comparative study of COSMO-based and equation-of-state approaches for the prediction of solvation energies based on the compsol databank
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Francisco Carlos Paes, Romain Privat, Jean-Noël Jaubert, Baptiste Sirjean, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and European Project: 101003318
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General Chemical Engineering ,General Physics and Astronomy ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Physical and Theoretical Chemistry - Abstract
International audience; The computation of solvation energies has many uses in several fields, such as design of separation processes, pharmacology and drug-design, and kinetic modeling. These applications require thermodynamic models capable of accurately predicting solvation energies, accounting for the temperature dependency of this property, and which are fast and robust. Within this framework, we compared two COSMO-based continuum solvation models (COSMO-RS and COSMO-SAC-dsp) with two versions of predictive cubic equations of state well-acknowledged for their efficiency (PSRK and UMR-PRU). For this purpose, a large experimental set of 65,000 datapoints extracted from the COMPSOL databank was considered. Comparisons between computed and experimental data were performed for Gibbs solvation energy and, for the first time in the literature, for both entropy and enthalpy of solvation simultaneously. For simpler binary mixtures, in which hydrogen bonding does not take place, all models were capable of providing accurate predictions, with average absolute deviations below 0.3 kcal/mol regarding the solvation Gibbs energy. For more complex associating mixtures, COSMO-RS showed the best correlation between experimental and calculated data, especially for aqueous systems; among EoS, it is observed that the PSRK model offers the best accuracy.
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- 2022
66. Formation et évolution des aérosols dans l’atmosphère de Titan
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Biennier, Ludovic, Carles, Sophie, Mortada, Ahmad, Demes, S., Lique, Francois, Joalland, Baptiste, Lavvas, P., Calvo, Florent, Bourgalais, Jérémy, Carrasco, Nathalie, Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Groupe de spectrométrie moléculaire et atmosphérique (GSMA), Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Biennier, Ludovic
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[PHYS]Physics [physics] ,[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM] ,[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] ,[PHYS.ASTR.IM] Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM] ,Molecular physics ,[PHYS] Physics [physics] ,[PHYS.PHYS.PHYS-CHEM-PH] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] - Abstract
National audience; Les observations effectuées par les instruments embarqués à bord de l’orbiteur Cassini montrent que la croissance moléculaire mise en évidence dans l’ionosphère de Titan mène à la formation d’aérosols. Des études récentes de la physico-chimie de cette couche de l’atmosphère ont établi que les ions lourds positifs et négatifs détectés par spectrométrie de masse sont des embryons d’aérosols.En dépit de ces avancées, de nombreuses interrogations demeurent. Un des objectifs des travaux menés consiste à comprendre le rôle exact des ions dans la formation des aérosols en examinant les collisions élémentaires à l’aide d’un réacteur produisant un écoulement supersonique uniforme couplé à une source sélective d’ions (CRESU-SIS). De façon complémentaire, un autre objectif consiste à simuler la croissance des ions dans un réacteur plasma (PAMPRE) ou photochimique (APSIS) et à comparer les produits ionisés avec les spectres mesurés par les instruments INMS et CAPS-ELS embarqués à bord de Cassini.Pour mener à bien ces études, nous associons modélisateurs, physico-chimistes expérimentateurs et théoriciens. Il est clair en effet que la compréhension de la photochimie des atmosphères planétaires froides, en particulier celle de Titan, passe par l’identification des processus clés ainsi que par l'obtention théorique et expérimentale d'un grand nombre de données fiables et sur les réactions et processus physico-chimiques à très basses températures (< 200 K) et leur utilisation dans des modèles photochimiques atmosphériques réalistes.
- Published
- 2022
67. Exp'Eau, a hybrid serious game to explore pathways towards better water quality in rural catchments
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Barreteau, Olivier, Charpentier, Isabelle, Elouati, Hossam, Kelhetter, Hugo, Kudriashov, Daniil, Blanchoud, Hélène, Bonnefond, Mathieu, Dousset, Sylvie, Gouy, Véronique, Piscart, Christophe, Pons, Marie-Noëlle, Ragueneau, Olivier, Salvador-Blanes, Sébastien, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), LTSER-FR Zone Atelier Enviironnementale Urbaine (LTSER-FR ZAEU), Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols (METIS), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), LTSER-FR Zone Atelier Seine, Laboratoire Géomatique et foncier (GeF), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Laboratoire Interdisciplinaire des Environnements Continentaux (LIEC), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Terre et Environnement de Lorraine (OTELo), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Zone Atelier du Bassin de la Moselle [LTSER France] (ZAM), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), LTSER-FR Zone Atelier Rhône, Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), LTSER Zone Atelier Armorique (LTSER), Laboratoire Réactions et Génie des Procédés (LRGP), Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), LTSER-FR Zone Atelier Brest Iroise, GéoHydrosystèmes COntinentaux (GéHCO EA6293), Université de Tours (UT), and LTER France, LTSER Zone Atelier Loire
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[SDE.ES]Environmental Sciences/Environmental and Society - Abstract
International audience; Agriculture is considered today as having major impacts on water quality in river basins. Transitionfrom this situation to a better integration of agricultural practices in their environment is sought bymany stakeholders and policy makers, from water, land development and also agriculture sectors.This appears costly when incorporating their various constraints. With the on-going research projectExpEau, the LTSER-FR network aims at (1) raising awareness on the opportunities to handleagricultural sources of water pollution collectively, and (2) comparing them in various watersheds.To that end, we are developing a hybrid serious game featuring activities and relations betweenfarmers, municipalities and river basin organization on a virtual river basin, generated from actualdatasets for topography, soil properties, and climate. For comparison sake, the game features aframed number of entities and possibilities of action, and the process of transforming actual datasetsis standardized. We consider representative small basins (ca. 100 km2) that we discretize into threesub-basins, each of them representing a municipality as the first level for collaboration. Each subbasin counts about 30 hexagons elementary tiles with a single land use for each.In practice, the game is made of a physical board and playing action cards, as well as a twin on-lineversion. Farmer players access to the information on their environment and choose cultural practicesthanks to a smartphone. Municipality and river basin organisation roles use their time and budget tofacilitate collaboration and support more virtuous practices as well as infrastructures to decreasepollution. A local server computes the impacts of these actions in terms of production, collective well-being and contamination, and updates the players’ data.During the game session, players can see the virtual watershed, the land use and the infrastructureson the physical board. According to their role, they receive situated information on production, onterritorial well-being and water quality and quantity.Involving students or local stakeholders, each session is followed by a debriefing that could produce(1) a local understanding on the interactions between agriculture and water quality, and (2) socio-ecosystem data to feed a cross LTSER analysis of these interactions.
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- 2022
68. Rebalancing the historical female under-representation in education
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Nicolas Dietrich, Gaëlle Lebrun, Kalyani Kentheswaran, Mathias Monnot, Patrick Loulergue, Carine Franklin, Florence Teddé-Zambelli, Chafiaa Djouadi, Sébastien Leveneur, Mallorie Tourbin, Yolaine Bessière, Carole Coufort-Saudejaud, Annabelle Couvert, Eric Schaer, Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Universitaire de Technologie - Aix-Marseille (IUT AMU), Aix Marseille Université (AMU), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Education, Formation, Travail, Savoirs (EFTS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Laboratoire de Sécurité des Procédés Chimiques (LSPC), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Laboratoire de Génie Chimique (LGC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse - Jean Jaurès (UT2J)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Normandie Université (NU), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées
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Upper-Division Undergraduate < Audience ,First-Year Undergraduate/General < Audience ,General Chemistry ,Graduate Education ,First-Year Undergraduate / General < Audience ,Public Understanding/Outreach < Domain ,[SDE.ES]Environmental Sciences/Environmental and Society ,Education ,[SHS]Humanities and Social Sciences ,History/Philosophy < Domain ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,Graduate Education/Research < Audience ,[CHIM]Chemical Sciences ,Second-Year Undergraduate < Audience ,Chemical Engineering < Domain ,General Public < Audience - Abstract
International audience; Women are increasingly present in the field of engineering, and despite a significant female presence, it has been found that the programmes continue to make no reference to women scientists. In chemical engineering, for example, all the names of scientists mentioned in the programmes belong to men only. To test this hypothesis of the overrepresentation of men in the programmes, a series of random opinion surveys were launched among 600 students from 5 universities to find out whether they had noticed this over-representation and what they thought about it. The results showed that the vast majority did not realize that the scientists presented as examples in classes were all men. In fact, 90% of the student panel were unable to identify a woman in the chemical engineering field, and the remaining 10% could cite only one or two-who were among the most recent and had received most attention from the media. The issue of inequalities between girls and boys and between women and men in education remains central to understanding and combating gender inequalities and to enabling people to develop as persons free from the limitations imposed on them by gender stereotypes. However, these inequalities cannot be explained exclusively by the issue of access to education but must also take the type and content of education into account. This article is a call for reflection on the content of university curricula and has a twofold objective: on the one hand, to raise awareness of this imbalance in representation among students, both male and female, and, on the other hand, to launch reflection on this "invisibility of women" and to propose some avenues for debate.
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- 2022
69. L’étude rhéologique de fontes verrières nucléaires contenant des agrégats de platinoïdes
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Pereira Machado, Norma-Maria, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Lorraine, Philippe Marchal, Cécile Lemaitre, and UL, Thèses
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[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,[CHIM.GENI] Chemical Sciences/Chemical engineering ,Platinum Group Metals (PGM) ,Thixotropie ,Rhéologie ,Aggregation ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,Sédimentation ,Platinoïdes ,Agrégation ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Rheology ,Thixotropy ,Sedimentation - Abstract
In France, borosilicate glass is used as a matrix to immobilize nuclear fission products resulting from spent fuel reprocessing. In the high-temperature vitrification process (1200 °C), most of elements to be contained react chemically with the vitrification additives to form a homogeneous glass melt. Platinum Group Metal (PGM) particles are not soluble in the melt and therefore are present as suspended particles of few microns. These particles exhibit an intense aggregation tendency and consequently the suspensions may present an anomalously high apparent viscosity. These systems are characterized by a shear-thinning and a thixotropic behaviors. The present study aims to provide important inputs for the overall rheological behavior of this system and its features through the characterization of a simulated nuclear glass melt containing 3.0 wt% (1.02 vol%) of PGM particles. A mathematical modeling of the thixotropic behavior of glass melts containing PGM particles is presented for the first time using a model similar to that proposed by Houska (Houska, 1981). This predictive model allow to describe experimental results obtained both in steady state and transient conditions. The impact of the shear stress and time on PGM aggregation degree and sedimentation kinetics is determined using an imposed-stress rheometer at high temperature and imaging analyses via Scanning Electron Microscopy (SEM). For the first time, the interplay between the rheological behavior of the system and the aggregation degree is provided, as well as the link with the particles settling. Based on the acquired experimental data, a force balance computation is executed to illustrate the different aggregation scenarios. The work provides a new input for the modeling and control of the vitrification process., En France, les produits de fission nucléaire issus du retraitement des combustibles usés sont conditionnés au sein de matrices de verres borosilicatés. Lors du processus de vitrification à haute température (1200 °C), les éléments à confiner réagissent chimiquement avec les additifs de vitrification pour former un verre homogène. Cependant, parmi ces éléments, les platinoïdes ne sont pas solubles dans le bain de verre et restent en suspension sous forme de particules de quelques microns. Ces particules présentent une forte tendance à l'agrégation et les suspensions peuvent alors présenter une viscosité apparente anormalement élevée. Ces systèmes sont caractérisés par un comportement rhéofluidifiant et thixotrope. La présente étude vise à fournir des données importantes sur le comportement rhéologique global de ces systèmes et leurs propriétés, grâce à la caractérisation d'un verre nucléaire simulé contenant 3,0 % massique (1,02 % en volume) de platinoïdes. Une modélisation mathématique du comportement thixotrope de ce verre est présentée pour la première fois en utilisant un modèle similaire à celui proposé par Houska (Houska, 1981). Ce modèle prédictif permet la description des résultats expérimentaux obtenus à partir de mesures en régimes permanent et transitoire. L'impact de la contrainte de cisaillement et du temps sur le degré d'agrégation et la cinétique de sédimentation des particules est déterminé à l'aide d'un rhéomètre à contrainte imposée opéré à haute température et d'analyses d'images obtenues par microscopie électronique à balayage (MEB). Pour la première fois, l'interaction entre le comportement rhéologique du système et le degré d'agrégation est analysé, tout comme le lien avec la sédimentation des particules. Sur la base des données expérimentales acquises, un calcul d'équilibre des forces est réalisé pour illustrer les différents scénarios d'agrégation. Ce travail fournit des nouvelles données pour la modélisation et le contrôle du processus de vitrification.
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- 2022
70. Nanoparticles for MRI and vascular photodynamic treatment of brain tumor
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Bechet, Denise, Couleaud, Pierre, Vanderesse, Régis, Frochot, Céline, Faure, Anne-Charlotte, Mordon, Serge, Roux, Stéphane, Tillement, Olivier, Guillemin, François, Barberi-Heyob, Muriel, Auger, Florent, Centre Alexis Vautrin (CAV), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut de médecine predictive et de recherche thérapeutique (IMPRT), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin ( CAV ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Chimie Physique Macromoléculaire ( LCPM ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Institut de médecine predictive et de recherche thérapeutique ( IMPRT ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -CRLCC Oscar Lambret-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Laboratoire de Mécanique et Technologie ( LMT ), École normale supérieure - Cachan ( ENS Cachan ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche en Automatique de Nancy ( CRAN ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Wolf, Didier, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Université de Lille-UNICANCER-Université de Lille-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
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[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering - Published
- 2010
71. Nanoparticles for MRI and vascular photodynamic treatment of brain tumours
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Barberi-Heyob , Muriel, Frochot , Céline, Vanderesse , Régis, Tillement , Olivier, Lux , François, Mordon , Serge, Bastogne , Thierry, Guillemin , François, Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin (CAV), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut de médecine predictive et de recherche thérapeutique (IMPRT), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université de Lille-UNICANCER-Université de Lille-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche en Automatique de Nancy ( CRAN ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Alexis Vautrin ( CAV ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Chimie Physique Macromoléculaire ( LCPM ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Institut de médecine predictive et de recherche thérapeutique ( IMPRT ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -CRLCC Oscar Lambret-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), and Wolf, Didier
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[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2010
72. The use of nanoparticles for photodynamic therapy agent delivery
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Couleaud, Pierre, Bechet, Denise, Barberi-Heyob, Muriel, Vanderesse, Régis, Kamarulzaman, Ezatul-Ezleen, Faure, Anne-Charlotte, Tillement, Olivier, Roux, Stéphane, Frochot, Céline, Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Alexis Vautrin ( CAV ), Centre de Recherche en Automatique de Nancy ( CRAN ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Chimie Physique Macromoléculaire ( LCPM ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Mécanique et Technologie ( LMT ), École normale supérieure - Cachan ( ENS Cachan ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Wolf, Didier, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin (CAV), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
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[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,ComputingMethodologies_GENERAL ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering ,ComputingMilieux_MISCELLANEOUS - Abstract
Poster; International audience
- Published
- 2010
73. New multifunctional platform for diagnosis and photodynamic therapy applications
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Couleaud, Pierre, Bechet, Denise, Barberi-Heyob, Muriel, Vanderesse, Régis, Faure, Anne-Charlotte, Roux, Stéphane, Tillement, Olivier, Frochot, Céline, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin (CAV), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Wolf, Didier, Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Alexis Vautrin ( CAV ), Centre de Recherche en Automatique de Nancy ( CRAN ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Chimie Physique Macromoléculaire ( LCPM ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Mécanique et Technologie ( LMT ), École normale supérieure - Cachan ( ENS Cachan ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
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[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2010
74. Nanoparticules multifonctionnelles pour la thérapie photodynamique
- Author
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Couleaud, Pierre, Bechet, Denise, Frochot, Céline, Vanderesse, Régis, Bastogne, Thierry, Pernot, Marlène, Faure, Anne-Charlotte, Roux, Stéphane, Tillement, Olivier, Barberi-Heyob, Muriel, Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Alexis Vautrin ( CAV ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Chimie Physique Macromoléculaire ( LCPM ), Centre de Recherche en Automatique de Nancy ( CRAN ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Mécanique et Technologie ( LMT ), École normale supérieure - Cachan ( ENS Cachan ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin (CAV), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Wolf, Didier, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon
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[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering - Published
- 2010
75. Carbon dioxide is largely responsible for the acute inflammatory effects of tobacco smoke
- Author
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Laurent Schwartz, Abolhassani Mohammad, Georges Grevillot, Thierry Jo Molina, Philippe Chaumet-Riffaud, Adeline Guais, Annie J. Sasco, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biorébus, SARL, UFR de Bicêtre, Université Paris-Sud - Paris 11 (UP11), Service de Biophysique et de Médecine Nucléaire, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Laboratoire des Sciences du Génie Chimique (LSGC), Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Hôtel Dieu, Nosco Pharmaceuticals, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Radiothérapie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), NOSCO PHARMACEUTICALS, Recherche-développement en biotechnologie, Assistance publique - Hôpitaux de Paris (AP-HP), Université Paris-Sud - Paris 11 ( UP11 ), Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Université Paris Descartes - Paris 5 ( UPD5 )
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Male ,Chronic bronchitis ,Health, Toxicology and Mutagenesis ,Pharmacology ,Toxicology ,Tobacco smoke ,Proinflammatory cytokine ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Smoke ,Animals ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Sidestream smoke ,Lung ,030304 developmental biology ,0303 health sciences ,Inhalation Exposure ,Mice, Inbred BALB C ,Inhalation ,Chemistry ,Smoking ,[ SPI.GPROC ] Engineering Sciences [physics]/Chemical and Process Engineering ,Carbon Dioxide ,3. Good health ,13. Climate action ,030220 oncology & carcinogenesis ,Toxicity ,Chronic inflammatory response ,Inflammation Mediators - Abstract
International audience; Tobacco smoking is responsible for a vast array of diseases, particularly chronic bronchitis and lung cancer. It is still unclear which constituent(s) of the smoke is responsible for its toxicity. The authors decided to focus on carbon dioxide, since its level of concentration in mainstream cigarette smoke is about 200 times higher than in the atmosphere. The authors previously demonstrated that inhalation of carbon dioxide concentrations above 5% has a deleterious effect on lungs. In this study, the authors assessed the inflammatory potential of carbon dioxide contained in cigarette smoke. Mice were exposed to cigarette smoke containing a high or reduced CO2 level by filtration through a potassium hydroxyde solution. The inflammatory response was evaluated by histological analysis, protein phosphatase 2 A (PP2A) and nuclear factor (NF)-κB activation, and proinflammatory cytokine secretion measurements. The data show that the toxicity of cigarette smoke may be largely due to its high level of CO2. Pulmonary injuries consequent to tobacco smoke inhalation observed by histology were greatly diminished when CO2 was removed. Cigarette smoke exposure causes an inflammatory response characterized by PP2A and NF-κB activation followed by proinflammatory cytokine secretion. This inflammatory response was reduced when the cigarette smoke was filtered through a potassium hydroxide column, and reestablished when CO2 was injected downstream from the filtration column. Given that there is an extensive literature linking a chronic inflammatory response to the major smoking-related diseases, these data suggest that carbon dioxide may play a key role in the causation of these diseases by tobacco smoking.
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- 2010
76. Functionalized silica-based nanoparticles for photodynamic therapy
- Author
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Anne-Charlotte Faure, Pierre Couleaud, Denise Bechet, Céline Frochot, Stéphane Roux, Olivier Tillement, Muriel Barberi-Heyob, François Guillemin, Régis Vanderesse, Sabine Porhel, Laboratoire Réactions et Génie des Procédés ( LRGP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche en Automatique de Nancy ( CRAN ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Alexis Vautrin ( CAV ), Laboratoire de Chimie Physique Macromoléculaire ( LCPM ), Médicaments Photoactivables - Photochimiothérapie ( PHOTOMED ), Institut de Chimie du CNRS ( INC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Mécanique et Technologie ( LMT ), École normale supérieure - Cachan ( ENS Cachan ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin (CAV), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon
- Subjects
Materials science ,Cell Survival ,medicine.medical_treatment ,Biomedical Engineering ,Medicine (miscellaneous) ,Nanoparticle ,Bioengineering ,Photodynamic therapy ,Peptide ,02 engineering and technology ,Development ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,Photosensitivity ,Cell Line, Tumor ,Neuropilin 1 ,medicine ,Humans ,General Materials Science ,Photosensitizer ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering ,ComputingMilieux_MISCELLANEOUS ,chemistry.chemical_classification ,Photosensitizing Agents ,Molecular Structure ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,Neuropilin-1 ,Recombinant Proteins ,In vitro ,0104 chemical sciences ,Photochemotherapy ,Biochemistry ,chemistry ,Chlorin ,Biophysics ,Nanoparticles ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Peptides ,0210 nano-technology - Abstract
Aim: The strategy developed aims to favor the vascular effect of photodynamic therapy by targeting tumor-associated vascularization using peptide-functionalized nanoparticles. We previously described the conjugation of a photosensitizer to a peptide targeting neuropilin-1 overexpressed in tumor angiogenic vessels. Materials & Methods: In this study, we have designed and photophysically characterized a multifunctional nanoparticle consisting of a surface-localized tumor vasculature targeting peptides and encapsulated photodynamic therapy and imaging agents. Results & Conclusion: The elaboration of these multifunctional silica-based nanoparticles is reported. Nanoparticles functionalized with approximately 4.2 peptides bound to recombinant neuropilin-1 protein. Nanoparticles conferred photosensitivity to cells overexpressing neuropilin-1, providing evidence that the chlorin grafted within the nanoparticle matrix can be photoactivated to yield photocytotoxic effects in vitro.
- Published
- 2010
77. High production of L-glutamic acid from date juice extracts by Corynebacterium glutamicum using fed-batch cultures: pulsed and continuous feeding modes
- Author
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Mouffok Abdenacer, Nancib Aïcha, Boudrant Joseph, Nancib Nabil, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Laboratory of Applied Microbiology, Department of Microbiology, Faculty of Nature and Life Sciences, Ferhat Abbas University-Setif 1, 19000 Setif
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0106 biological sciences ,Pulmonary and Respiratory Medicine ,Geography (General) ,0303 health sciences ,feeding mode ,Chemistry ,Science ,date juice ,Continuous feeding ,Glutamic acid ,01 natural sciences ,Corynebacterium glutamicum ,[SPI]Engineering Sciences [physics] ,03 medical and health sciences ,010608 biotechnology ,G1-922 ,Feeding mode ,l-glutamic acid ,fed-batch fermentation ,Pediatrics, Perinatology, and Child Health ,Food science ,corynebacterium glutamicum ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology - Abstract
In the present work, L-glutamic acid production by Corynebacterium glutamicum fermentation on date juice extracts applying two fed-batch feeding modes, pulsed and continuous, were investigated. According to the obtained results, the continuous feeding fed-batch mode was found to be the most efficient process. Moreover the continuous feeding rate mode with a feeding medium containing date juice sugars enriched with ammonium sulfate was found even more favorable as it enhances the L-glutamic acid production by approximately 2.35 fold more than the batch culture and by about 1.17 fold more than the pulsed feeding. In this respect, comparing the traditional batch culture to the continuously fed culture with a medium containing date juice sugars with ammonium sulfate showed increases of 135.47% in L-glutamic acid production, 104% in productivity, 39.09% in biomass, and 47.69% in the yield respectively allowing us to reach a final L-glutamic acid concentration of about 138 g/L, the highest ever published.
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- 2021
78. Sunflower Proteins at Air–Water and Oil–Water Interfaces
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Alexandre Poirier, Antonio Stocco, Martin In, Romain Kapel, Laurence Ramos, Amélie Banc, Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Sadron (ICS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), ANR-18-CE06-0012,ELASTOBIO,Gels élastomériques de biopolymères soumis à des déformations extrêmes(2018), ANR-10-IEED-0001,PIVERT,Picardie Innovations Végétales, Enseignement et Recherches Technologiques(2010), KAPEL, Romain, APPEL À PROJETS GÉNÉRIQUE 2018 - Gels élastomériques de biopolymères soumis à des déformations extrêmes - - ELASTOBIO2018 - ANR-18-CE06-0012 - AAPG2018 - VALID, Picardie Innovations Végétales, Enseignement et Recherches Technologiques - - PIVERT2010 - ANR-10-IEED-0001 - IEED - VALID, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
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Hydrodynamic radius ,Surface Properties ,[SPI] Engineering Sciences [physics] ,Globular protein ,Population ,02 engineering and technology ,Physique [physics]/Physique [physics] ,010402 general chemistry ,01 natural sciences ,Surface-Active Agents ,[SPI]Engineering Sciences [physics] ,Adsorption ,Phase (matter) ,Monolayer ,Electrochemistry ,General Materials Science ,education ,Spectroscopy ,chemistry.chemical_classification ,education.field_of_study ,Chemistry ,Aqueous two-phase system ,Water ,Surfaces and Interfaces ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,0104 chemical sciences ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,Chemical engineering ,Plant protein ,Helianthus ,0210 nano-technology - Abstract
International audience; The adsorption of a sunflower protein extract at two air− water and oil−water interfaces is investigated using tensiometry, dilational viscoelasticity, and ellipsometry. For both interfaces, a three step mechanism was evidenced thanks to master curve representations of the data taken at different aging times and protein concentrations. At short times, a diffusion limited adsorption of proteins at interfaces is demonstrated. First, a two-dimensional protein film is formed with a partition of the polypeptide chains in the two phases that depends strongly on the nature of the hydrophobic phase: most of the film is in the aqueous phase at the air−water interface, while it is mostly in the organic phase at the oil−water interface. Then a three-dimensional saturated monolayer of proteins is formed. At short times, adsorption mechanisms are analogous to those found with typical globular proteins, while strong divergences are observed at longer adsorption times. Following the saturation step, a thick layer expands in the aqueous phase and appears associated with the release of large objects in the bulk. The kinetic evolution of this second layer is compatible with a diffusion limited adsorption of the minor population of polymeric complexes with hydrodynamic radius R H ∼ 80 nm, evidenced in equilibrium with hexameric globulins (R H ∼ 6 nm) in solution. These complexes could result from the presence of residual polyphenols in the extract and raise the question of the role of these compounds in the interfacial properties of plant protein extracts.
- Published
- 2021
79. Intensification of Polymerization Processes by Reactive Extrusion
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Lian-Fang Feng, Guohua Hu, Tian-Tian Li, Cai-Liang Zhang, Pan Wang, Xue-Ping Gu, State Key Laboratory of Chemical Engineering (Polymerization Division), Zhejiang University, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université de Lorraine (UL), and Université de Lorraine
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Materials science ,General Chemical Engineering ,Continuous reactor ,02 engineering and technology ,General Chemistry ,Reactive extrusion ,021001 nanoscience & nanotechnology ,7. Clean energy ,Industrial and Manufacturing Engineering ,020401 chemical engineering ,Polymerization ,Chemical engineering ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,0204 chemical engineering ,0210 nano-technology ,ComputingMilieux_MISCELLANEOUS - Abstract
The unique geometry of screw extruders allows handling very viscous media; thus, they can be used as continuous reactors to conduct polymerization reactions without using any solvents. This is call...
- Published
- 2021
80. Blepharidium guatemalense, an obligate nickel hyperaccumulator plant from non-ultramafic soils in Mexico
- Author
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Jesús Axayacatl Cuevas Sánchez, Michel Cathelineau, Antony van der Ent, A. Joseph Pollard, Dulce Montserrat Navarrete Gutiérrez, Guillaume Echevarria, Marie-Noëlle Pons, Laboratoire Sols et Environnement (LSE), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidad Autónoma de Chapingo (UACh), Furman University, University of Queensland, Sustainable Minerals Institute, Centre for Mined Land Rehabilitation (SMI-CMLR (UQ)), University of Queensland [Brisbane], GeoRessources, Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre de recherches sur la géologie des matières premières minérales et énergétiques (CREGU)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and ANR-10-LABX-0021,RESSOURCES21,Strategic metal resources of the 21st century(2010)
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0106 biological sciences ,chemistry.chemical_element ,Rubiaceae ,01 natural sciences ,Biochemistry ,Ultramafic rock ,Botany ,Hypernickelophore ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,Hyperaccumulator ,ComputingMilieux_MISCELLANEOUS ,Ecology, Evolution, Behavior and Systematics ,Rhizosphere ,Agromining ,Ionomics ,biology ,Biogeochemistry ,[SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics ,15. Life on land ,biology.organism_classification ,XRF scanning ,010602 entomology ,Nickel ,Herbarium ,chemistry ,visual_art ,ddc:540 ,visual_art.visual_art_medium ,Bark ,Phloem ,[SDE.BE]Environmental Sciences/Biodiversity and Ecology ,010606 plant biology & botany - Abstract
Nickel hyperaccumulation in Blepharidium guatemalense Standl. (Rubiaceae) was found in the tropical forests of south-eastern Mexico. This study aimed to document the geographic extent of nickel hyperaccumulation in this species, to understand its process of hyperaccumulation and to explore nickel distribution within the tissues of this plant. To accomplish these objectives, a complete non-destructive elemental screening of herbarium specimens was performed with a hand-held X-ray fluorescence spectrometer. Besides, rhizosphere soils and plant tissues were collected in Mexico and analyzed for physical–chemical parameters. Finally, elemental distribution maps of nickel and other elements in plant tissues were obtained by X-ray fluorescence spectroscopy and microscopy. This study revealed that Blepharidium guatemalense is distributed throughout Chiapas, Tabasco and Campeche, reaching the maximum nickel concentration in leaves (4.3 wt%) followed by roots and seeds (2.0 wt%) and bark (1.8 wt%). Simultaneous hyperaccumulation of cobalt and nickel was found in 15% of the herbarium specimens. Blepharidium guatemalense has uncommon re-distribution mechanisms via phloem since this tissue is the highest nickel-enriched from all parts of the plant (from roots to leaves). A high total nickel (mean of 610 µg g−1) was found in rhizosphere soils even though no evidence of ophiolite emplacement in that area has been reported. Blepharidium guatemalense represents the first hypernickelophore (> 1 wt% Ni) to be reported as growing in soils that are neither ultramafic nor enriched by anthropogenic pollutants.
- Published
- 2021
81. Rheological investigation of supramolecular physical gels in water/dimethylsulfoxide mixtures by lysine derivatives
- Author
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Géraldine Rangel Euzcateguy, Caroline Parajua-Sejil, Philippe Marchal, Marie-Christine Averlant-Petit, Guillaume Pickaert, Loic Stefan, David Chapron, Alain Durand, Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Laboratoire Réactions et Génie des Procédés (LRGP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Laboratoire Matériaux Optiques, Photonique et Systèmes (LMOPS), and CentraleSupélec-Université de Lorraine (UL)
- Subjects
Polymers and Plastics ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,Chemistry ,Organic Chemistry ,Lysine ,Kinetics ,Supramolecular chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,3. Good health ,0104 chemical sciences ,Chemical engineering ,Rheology ,Materials Chemistry ,[CHIM]Chemical Sciences ,0210 nano-technology ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2021
82. Experimental and kinetic modeling of the ignition delays of cyclohexane, cyclohexene, and cyclohexadienes: Effect of unsaturation
- Author
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Baptiste Sirjean, J.-C. Lizardo-Huerta, F. Isufaj, L. Giarracca, Pierre-Alexandre Glaude, René Fournet, Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Pericyclic reaction ,Materials science ,Cyclohexane ,General Chemical Engineering ,Cyclohexene ,Thermodynamics ,010402 general chemistry ,Combustion ,7. Clean energy ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,law ,0103 physical sciences ,Reactivity (chemistry) ,Physical and Theoretical Chemistry ,Benzene ,ComputingMilieux_MISCELLANEOUS ,010304 chemical physics ,Mechanical Engineering ,Decomposition ,0104 chemical sciences ,Ignition system ,chemistry ,13. Climate action - Abstract
Cyclic and aromatic hydrocarbons are important components of usual commercial fuels, with C6-rings being among the most abundant cyclic structures. The combustion chemistry of C6-rings involves different levels of unsaturation, either as initial fuels (aromatics, naphtenes, …) or as intermediates formed during their combustion. In this work the ignition delays of cyclohexane, cyclohexene, 1,3-cyclohexadiene and 1,4-cyclohexadiene are systematically studied using experiments and kinetic modeling. Shock tube experiments were performed at high-temperature (above 1200 K) and for mean pressures of 6 atm. A detailed chemical kinetic model was developed that includes the combustion chemistry of the four cyclo-C6 fuels. Electronic structure calculations were performed at the CCSD(T)/CBS//B2PLYP-D3 level of theory on the pericyclic reactions of the unsaturated fuels. Pressure-dependent rate coefficients were computed by solving the master equation, and included in the mechanism. The model was validated against the new ignition data and against data of the literature. It was able to reproduce the experimental ranking of reactivity: cyclohexene > 14-CHD > cyclohexane > benzene ≈13-CHD. Kinetic analyses were performed to explain this difference of reactivity. It is shown that pericyclic reactions play a major role in the initial decomposition of the unsaturated fuels.
- Published
- 2021
83. Theoretical study of the pyrolysis of β-1,4-xylan: a detailed investigation on unimolecular concerted reactions
- Author
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René Fournet, Baptiste Sirjean, M. Goussougli, Pierre-Alexandre Glaude, Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
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chemistry.chemical_classification ,Thermal decomposition ,Xylan (coating) ,General Physics and Astronomy ,High activation ,Glycosidic bond ,02 engineering and technology ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Furfural ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,[CHIM.POLY]Chemical Sciences/Polymers ,chemistry ,Computational chemistry ,Elementary reaction ,Physical and Theoretical Chemistry ,0210 nano-technology ,Pyrolysis - Abstract
International audience; A theoretical study of the thermal decomposition of β-1,4-xylan, a model polymer of hemicelluloses, is proposed for the first time. A mechanism based on unimolecular concerted reactions is elaborated in a comprehensive way. Elementary reactions, such as dehydrations, retro-aldol, retro Diels–Alder, retro-ene, glycosidic bond fissions, isomerizations, etc., are applied to β-1,4-xylan, as well as to the fragments formed. At each stage of the construction of the mechanism, the fragments previously retained are decomposed and the low energy paths are selected to define new fragments. Energy barriers are computed at the CBS-QB3 level of theory and rate coefficients of important reactions are calculated. It is shown that the main reaction pathways can be modelled by reactions involving two specific fragments, which react in closed sequences, similarly to chain-propagating reactions. The proposed reaction scheme allows to predict important species observed during the pyrolysis of xylan, such as aldehydes or CO. In addition, we show that dehydrations require high activation energy and cannot compete with the other reactions. Therefore, it seems difficult to explain, by means of unimolecular homogeneous gas phase reactions, the significant formation of specific species such as furfural as reported by several authors.
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- 2021
84. Theoretical study of the gas-phase thermal decomposition of urea
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J. Honorien, René Fournet, Pierre-Alexandre Glaude, Baptiste Sirjean, Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
General Chemical Engineering ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Catalysis ,chemistry.chemical_compound ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,Reaction rate constant ,Theoretical ,Computational chemistry ,Urea ,Isocyanuric acid ,Physical and Theoretical Chemistry ,Chemistry ,Mechanical Engineering ,Thermal decomposition ,Kinetic model ,021001 nanoscience & nanotechnology ,Decomposition ,Biuret test ,0104 chemical sciences ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,Triuret ,0210 nano-technology ,Pyrolysis - Abstract
International audience; Urea is used in Selective Catalytic and Non Catalytic Reduction (SCR and SNCR) methods for NOx abatement in post-combustion processes. The decomposition of urea-water solution in exhaust systems leads to the formation of NH3, which is the NOx reducing agent. However, the decomposition of urea can also lead to the formation of unwanted pyrolysis by-products, particularly in region where the temperature and pressure conditions are not optimal or via wall-spray interactions. In this study, a gas phase kinetic model for urea pyrolysis is proposed to explain the growth of pyrolysis by-products of urea, and in particular, the route of formation of the major product: isocyanuric acid. Systematic theoretical calculations, using electronic structure calculations and transition state theory, were performed to explore all the possible unimolecular and bimolecular reactions of the initial species. Kinetic modeling was used to select the relevant reaction pathways at each growing step, and their rate constants were refined using CCSD(T)/CBS//B2PLYP-D3/cc-pvTZ calculations. Quantum calculations showed that the postulated growing schemes of the literature, based on the successive urea + HNCO ⇆ biuret, biuret + HNCO ⇆ triuret followed by the cyclization of triuret into isocyanuric acid are not energetically favored. It is observed that the most favored reaction route to isocyanuric acid involves carbamimidic acid, the urea tautomer, that first yields biuret in a reaction with HNCO and then is involved in the formation of triuret by reacting with a decomposition product of biuret. Isocyanuric acid is produced from the reaction between HNCO and the same decomposition product of biuret. This new mechanism of formation of isocyanuric acid is tested at different conditions to explore its most favored conditions of formation in the gas phase. Exploratory simulations of a pseudo condensed phase are also performed to qualitatively simulate condensed phase experiments and explain the observed pyrolysis yields.
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- 2021
85. The decisive role of pericyclic reactions in the thermal decomposition of organophosphorus compounds
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Pierre-Alexandre Glaude, L. Verdier, René Fournet, Baptiste Sirjean, J.-C. Lizardo-Huerta, Laboratoire Réactions et Génie des Procédés (LRGP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Délégation générale de l'armement (DGA), and Ministère de la Défense
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Organophosphorus compounds ,Pericyclic reaction ,DIMP ,General Chemical Engineering ,010402 general chemistry ,01 natural sciences ,theoretical chemistry ,sarin ,[SPI]Engineering Sciences [physics] ,Transition state theory ,chemistry.chemical_compound ,Reaction rate constant ,Computational chemistry ,0103 physical sciences ,Molecule ,Physical and Theoretical Chemistry ,DEMP ,Triethyl phosphate ,010304 chemical physics ,Chemistry ,Mechanical Engineering ,Thermal decomposition ,modeling ,Phosphonate ,Decomposition ,0104 chemical sciences ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,TEP ,chemical warfare agents - Abstract
International audience; The understanding of the thermal decomposition chemistry of chemical warfare nerve agents is largely limited by the scarcity of kinetic data. Because of the high toxicity of these molecules, experimental determination of their chemical properties is very difficult. In the present work, a comprehensive detailed kinetic model for the decomposition of sarin and some simulants, i.e. di-isopropyl methyl phosphonate (DIMP), diethyl methylphosphonate (DEMP), and triethyl phosphate (TEP) were developed, containing possible molecular and radical pathways. The importance of unimolecular pericyclic decomposition led to evaluate precisely the rate constants of these reactions with high level theoretical calculations. The QCISD(T)/cc-PV∞QZ//B2PLYPD3/6-311+G(2d,d,p) level of theory was selected after a benchmark. The contribution of hindered rotors was included with the 1D-HR-U approach. Tunneling was taken into account for H-atom transfer. Transition state theory was used to calculate high-pressure limit rate constants and pressure dependent rate constants were calculated using Master Equation modelling. The model was validated against experimental pyrolysis and oxidation experimental data available in literature. Flux analyses showed that whatever the conditions are, the first step of decomposition of the studied phosphorus compounds are pericyclic eliminations leading to successive decompositions, whereas bondbreaking or H-atom abstraction remain negligible, even at high temperature.
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- 2021
86. Mastering digitized chemical engineering
- Author
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Hermann J. Feise, Eric Schaer, Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
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Higher education ,business.industry ,Computer science ,4. Education ,General Chemical Engineering ,05 social sciences ,Frame (networking) ,Global warming ,050301 education ,Face (sociological concept) ,02 engineering and technology ,Employability ,Training methods ,Training (civil) ,Education ,[SPI]Engineering Sciences [physics] ,020401 chemical engineering ,Chemical engineering ,0204 chemical engineering ,business ,0503 education ,ComputingMilieux_MISCELLANEOUS - Abstract
This paper highlights the importance of digitalization in chemical engineering industries, in the frame of Industry 4.0, and the consequences on the employability and profession of chemical engineers. Training content must necessarily evolve to meet industry expectations and maintain the level of innovation required to meet the challenges of the future such as competitiveness, global warming, or depletion of resources. Higher Education Institutions must evolve, and digitalization also makes it possible to provide new training methods and tools that will help the teachers to face these challenges.
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- 2021
87. Production and antioxidant capacity of bioactive peptides from plant biomass to counteract lipid oxidation
- Author
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Frédéric Fine, Romain Kapel, Sophie Beaubier, Pierre Villeneuve, Isidora Ilic, Erwann Durand, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Terres Inovia, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), and Terres Innovia
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Antioxidant ,030309 nutrition & dietetics ,medicine.medical_treatment ,F60 - Physiologie et biochimie végétale ,Biomass ,Peptide ,Context (language use) ,Review Article ,Oxydation biochimique ,Applied Microbiology and Biotechnology ,Hydrolysate ,Antioxidants ,Food processing and manufacture ,03 medical and health sciences ,[SPI]Engineering Sciences [physics] ,0404 agricultural biotechnology ,Lipid oxidation ,Q02 - Traitement et conservation des produits alimentaires ,Biomasse ,medicine ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,TX341-641 ,Food science ,2. Zero hunger ,chemistry.chemical_classification ,0303 health sciences ,Plant biomass ,Nutrition. Foods and food supply ,Proteins ,Biological activity ,04 agricultural and veterinary sciences ,Q01 - Sciences et technologies alimentaires - Considérations générales ,Protéine ,TP368-456 ,040401 food science ,Antioxydant ,Amino acid ,chemistry ,Peptides ,Food Science ,Biotechnology - Abstract
Preventing lipid oxidation, especially with the polyunsaturated fat-based products, is a major concern in sectors as agri-food and cosmetic. Even though the efficiency of synthetic antioxidants has been recognized, both consumers and manufacturers are looking for more innovative, healthy and quality products while rejecting synthetic additives due to their concern about safety, along with their environmental impact issues. In this context, plant biomass, which have shown to be rich in compounds, have raised interest for the isolation of novel naturally occurring antioxidants. Among their myriad of molecules, bioactive peptides, which are biologically active sequence of amino acid residues of proteins, seem to be of a great interest. Therefore, the number of identified amino acids sequences of bioactive peptides from plant biomass with potential antioxidant action is progressively increasing. Thus, this review provides a description of 129 works that have been made to produce bioactive peptides (hydrolysate, fraction and/or isolate peptide) from 55 plant biomass, along with the procedure to examine their antioxidant capacity (until 2019 included). The protein name, the process, and the method to concentrate or isolate antioxidant bioactive peptides, along with their identification and/or specificity were described. Considering the complex, dynamic and multifactorial physico-chemical mechanisms of the lipid oxidation, an appropriate in-vitro methodology should be better performed to efficiently probe the antioxidant potential of bioactive peptides. Therefore, the results were discussed, and perspective for antioxidant applications of bioactive peptides from plant biomass was argued., Graphical abstract Image 1, Highlights • Exhaustive description of 129 works made to produce bioactive peptides from 55 plant biomass. • Controlled proteolysis can be used as a sustainable strategy to produce peptides. • Presentation of the important points to consider when estimating the antioxidant capacity of peptides. • Methodology should be improved to better probe the antioxidant potential of peptides.
- Published
- 2021
88. Time-resolved mixing and flow-field measurements during droplet formation in a flow-focusing junction
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Huai-Zhi Li, Odile Carrier, F. Gökhan Ergin, Denis Funfschilling, Bo Beltoft Watz, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés ( LRGP ), and Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS )
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Microchannel ,Chemistry ,Mechanical Engineering ,Microfluidics ,Flow (psychology) ,Mixing (process engineering) ,Analytical chemistry ,Mechanics ,[ CHIM ] Chemical Sciences ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,Electronic, Optical and Magnetic Materials ,Flow focusing ,Particle image velocimetry ,Mechanics of Materials ,Particle ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Electrical and Electronic Engineering ,Microscale chemistry - Abstract
International audience; Highly monodispersed emulsions can be produced in microfluidic flow-focusing junctions (Anna et al 2003 Appl. Phys. Lett. 82 364–6, Baroud et al 2010 Lab Chip 10 2032–45). This is the reason why many industrial processes in the medical industry among others are based on droplet manipulation and involve at some point a step of dripping within a junction. However, only a few studies have focused on the flow field inside and outside the droplet, even though it is a necessary step for understanding the physical mechanism involved and for modeling the droplet formation process. Water-in-oil emulsions are produced in flow-focusing junctions of square cross sections. The fluids constituting the emulsion are (i) a 5.0 mPacenterdots silicon oil for the oil phase and (ii) distilled water containing 2.0 wt% of sodium dodecyl sulfate surfactant for the aqueous phase. Time-resolved shadow particle images are acquired using a microscale particle image velocimetry (µPIV) system and flow fields are calculated using an adaptive PIV algorithm in combination with dynamic masking. Inside the microchannel and in the permanent regime, the droplet has an internal circulation that has been well established by Sarrazin et al (AICHE J. 52 4061–70). But during the formation of a droplet in a flow-focusing junction, the flow field is not so well known, and the circulation in the finger flows forward along the sides and returns along the center. The mechanism can be described in terms of four distinct steps: droplet growth, necking, rupture, and recoil. The liquid expelled from the neck just before rupture is also well observed. The flow field and mixing are measured in detail during a complete cycle of formation of a main droplet and satellite droplets using high-speed imaging. This allows us to develop a better understanding of the different forces that are present and of the physical mechanism of droplet formation
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- 2015
89. Don’t be afraid of the nanoparticles, it's just an ill-prepared nano-crisis
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Jean-Claude André, Céline Frochot, Éric Schaer, Laboratoire Réactions et Génie des Procédés (LRGP), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
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[SPI]Engineering Sciences [physics] ,Materials science ,Health, Toxicology and Mutagenesis ,Nano ,Public Health, Environmental and Occupational Health ,Nanoparticle ,Nanotechnology ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2020
90. Effect of lockdown on wastewater characteristics: a comparison of two large urban areas
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Davide A.L. Vignati, Marie-Noëlle Pons, Pauline Louis, Laboratoire Réactions et Génie des Procédés (LRGP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Zone Atelier du Bassin de la Moselle [LTSER France] (ZAM), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire des Environnements Continentaux (LIEC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Terre et Environnement de Lorraine (OTELo), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut Ecologie et Environnement (INEE), and Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
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Biochemical oxygen demand ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,Nitrogen ,Population ,Wastewater-based epidemiology ,Wastewater ,010501 environmental sciences ,Urban area ,Greywater ,Waste Disposal, Fluid ,01 natural sciences ,Toxicology ,Humans ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,education ,0105 earth and related environmental sciences ,Water Science and Technology ,Total suspended solids ,Biological Oxygen Demand Analysis ,geography ,education.field_of_study ,geography.geographical_feature_category ,Commuting ,SARS-CoV-2 ,Chemical oxygen demand ,COVID-19 ,Phosphorus ,Ammonium load ,[SDE.ES]Environmental Sciences/Environmental and Society ,6. Clean water ,Environmental science ,France ,Confinement ,Waste disposal - Abstract
The effect of the lockdown imposed to limit the spread of SARS-CoV-2 in France between March 14 and May 11, 2020 on the wastewater characteristics of two large urban areas (with between 250,000 and 300,000 inhabitants) was studied. The number of outward and inward daily commuters was extracted from national census databases related to the population and their commuting habits. For urban area A, with the larger number of daily inward commuters (110,000, compared to 53,000 for B), lockdown was observed to have an effect on the monthly load averages of chemical oxygen demand, biochemical oxygen demand, total Kjeldahl nitrogen, total suspended solids and total phosphorus, all of which decreased (confidence level of 95%). This decrease, which varied between 20% and 40% and reached 45% for COD, can be related to the cessation of catering and activities such as hairdressing, which generate large amounts of graywater. The ammonium loads, due to the use of toilets before leaving for work and after returning from work, remained constant. In the case of urban area B, lockdown had no noticeable effect. More data would be necessary in the long term to analyze the effect of changes in the balance between ammonia and carbon sources on the operation of wastewater treatment plants.
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- 2020
91. New Phenalenone Derivatives: Synthesis and Evaluation of Their Singlet Oxygen Quantum Yield
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Bauyrzhan Myrzakhmetov, Frédérique Brégier, Vincent Sol, Jérémy Godard, Yves Champavier, Philippe Arnoux, Céline Frochot, PEIRENE (EA 7500), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), PEIRENE (PEIRENE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)
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010405 organic chemistry ,Singlet oxygen ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,General Chemical Engineering ,Quantum yield ,General Chemistry ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Article ,0104 chemical sciences ,Chemistry ,chemistry.chemical_compound ,chemistry ,Photosensitizer ,QD1-999 ,Quantum ,ComputingMilieux_MISCELLANEOUS - Abstract
1H-Phenalen-1-one is a very efficient and easy-to-synthesize photosensitizer. Many substitutions have been previously described, but most of them significantly reduce the singlet oxygen quantum yield. The chloromethyl derivative described elsewhere is a good starting point for the synthesis of many useful derivatives because of the methylene bridge that saves its unique photosensitizing properties. Eighteen new phenalenone derivatives have been synthesized, bearing amine, carboxylic acid, alcohol, azide, and other major functional groups in organic chemistry. These reactions were carried out in good-to-excellent yields, and most of these new compounds retained the singlet oxygen quantum yield of the parent molecule. These new derivatives are very promising precursors for a number of applications such as the development of photosensitive antimicrobial agents or materials.
- Published
- 2020
92. Process safety education of future employee 4.0 in Industry 4.0
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Agnieszka Gajek, Niels Jensen, André Laurent, Bruno Fabiano, Laboratoire Réactions et Génie des Procédés (LRGP), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
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Industry 4.0 ,business.industry ,General Chemical Engineering ,Energy Engineering and Power Technology ,02 engineering and technology ,010501 environmental sciences ,Management Science and Operations Research ,Work in process ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,Engineering management ,[SPI]Engineering Sciences [physics] ,Process safety ,Control and Systems Engineering ,Taxonomy (general) ,Business ,0210 nano-technology ,Safety, Risk, Reliability and Quality ,Internet of Things ,Industrial Revolution ,Neologism ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences ,Food Science - Abstract
The term “Industry 4.0″, which refers to a fourth industrial revolution, is a recent neologism. The rise of digital technology including, artificial intelligence, the Internet of things and networks, “smart” and responsive devices, etc … is more and more omnipresent. In solving the related challenges of Industry 4.0, it is necessary to improve the involvement and training of employers and employees. This is particularly true for their education in process safety. Two surveys were submitted to the relevant stakeholders. Their results showed absence of industry 4.0 topics in the current courses on process safety. On the other hand, a review of the master's degree programs available in Europe revealed the recent emergence of new highly specialized courses in some of the topics of industry 4.0. The definition of “Safety 4.0″ leads to recommend two potential global training pathways, with one corresponding to the requirements of Industry 4.0 & Safety 4.0 intersections, recommended within the framework of pedagogical taxonomy models.
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- 2022
93. Impact of washing cycles on the performances of face masks
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Soleiman Bourrous, Daniel Ferry, Olivier Dufaud, Augustin Charvet, Mathieu Barrault, Laurence Jeanmichel, César Segovia, François-Xavier Ouf, Nathalie Bardin-Monnier, Stéphane Poirier, Marielle Pfrimmer, Victor Mocho, Olivier Grauby, Dominique Thomas, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Centre d'essai textile lorrain (CETELOR), Université de Lorraine (UL), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
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Fluid Flow and Transfer Processes ,Atmospheric Science ,Environmental Engineering ,Materials science ,010504 meteorology & atmospheric sciences ,Coronavirus disease 2019 (COVID-19) ,Mechanical Engineering ,Differential pressure ,010501 environmental sciences ,01 natural sciences ,Pollution ,law.invention ,Face masks ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,law ,Immersion (virtual reality) ,Particle ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Composite material ,Filtration ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences - Abstract
The tension on the supply of surgical and FFP2 masks during the first wave of the COVID-19 pandemic leads to study the potential reuse of these masks. As washing is easily adaptable at home, this treatment solution was retained. In this work, thirty-six references of surgical masks and four FFP2 masks were tested without being worn or washed and after several washing cycles. The results highlighted a great heterogeneity of performances depending on the mask trademarks, both for surgical masks and FFP2. The quality of the meltblown and spunbond layers and the presence/absence of electrostatic charges at the fiber surface are put forward to explain the variability of results, both on differential pressures and filtration efficiencies. The differential pressure and the particle filtration efficiency of the washed masks were maintained up to 10 washing cycles and met the standard requirements. However, an immersion in water with a detergent induces an efficiency decrease for submicronic particles. This lower performance, constant after the first washing cycle, can be explained by the loss of electrostatic charges during the washing cycle. The modifications of surface properties after washing also lead to a loss of the hydrophobic behavior of type IIR surgical masks, which can therefore no more be considered as resistant to blood projections.
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- 2022
94. Bio-Inspired Casein-Derived Antioxidant Peptides Exhibiting a Dual Direct/Indirect Mode of Action
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Gizella Csire, François Dupire, Laetitia Canabady-Rochelle, Katalin Selmeczi, Loic Stefan, Laboratoire Lorrain de Chimie Moléculaire (L2CM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), PhotoNS, ANR-15-IDEX-0004,LUE,Isite LUE(2015), and European Project: Synergie LO0024898,FEDER,FIRELIGHT(2018)
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Inorganic Chemistry ,[CHIM.COOR]Chemical Sciences/Coordination chemistry ,Physical and Theoretical Chemistry ,[CHIM.INOR]Chemical Sciences/Inorganic chemistry ,Antioxidants ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience; Antioxidant compounds are chemicals of primary importance, especially for their applications in nutrition and healthcare, thanks to their abilities to prevent oxidation processes and to limit and/or rebalance the oxidative stress, well-known for its impact on a wide variety of diseases. While several biomolecules are well-known for their antioxidant properties (e.g., ascorbic acid, carotenoids, phenolic derivatives), bio-sourced antioxidants have drawn considerable attention in the last decades, especially bioactive peptides, mainly obtained by the hydrolysis process. Antioxidant peptide sequences are mainly identified a posteriori, thanks to fastidious and time-consuming approaches and techniques, limiting the discovery of new efficient peptides. In this context and taking inspiration from nature, we report herein on a new series of three bio-inspired antioxidant peptides derived from the milk protein casein. These phosphopeptides, designed to chelate the redox-active iron(III) and forming highly soluble complexes up to pH 9, act both as indirect (i.e., inhibition of the metal redox activity) and direct (i.e., radical scavenging) antioxidants
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- 2022
95. Thermo-Physical characterization of Hexadecane during the solid/liquid phase change
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Nicolò R. Sgreva, Justine Noel, Christel Métivier, Philippe Marchal, Hadrien Chaynes, Mykola Isaiev, Yves Jannot, Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), European Project, Métivier, Christel, and PO FEDER-FSE Lorraine et Massif de Vosges 2014-2020 - INCOMING
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Condensed Matter::Soft Condensed Matter ,[SPI]Engineering Sciences [physics] ,Solidification ,Phase Change Materials ,Multi-scale characterization ,[SPI.MECA.MEFL] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,Hexadecane ,Melting ,Physical and Theoretical Chemistry ,Condensed Matter Physics ,Instrumentation ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] - Abstract
In this study we provide a multi-physical and multi-scale characterization of an organic Phase Change Material (PCM), i.e. hexadecane, for both itsliquid and solid phases and during the phase transition. Macroscopic thermal and physical properties provided are density and viscosity in the liquidphase and thermal conductivity and heat capacity in each phase. Further macroscopic measurements were done by differential scanning calorimetry (DSC), which was used to obtain a first estimation of temperatures at which the solid/liquid phase transition occurs. DSC results always show a well pronounced thermal hysteresis between melting (Tm) and solidification temperature (Ts). A similar hysteresis was also collected during rotational and oscillatory rheometry at the phase change, where Ts is found to depend on the applied cooling rate. Moreover, near Ts the forming solid structure is continuously affected by conditions imposed by the rheometer (i.e. applied shear rate or stress) and the breakage of crystals takes place even for the smallest imposed stress tested (0.001 Pa). Beside the bulk behavior, the local melting and solidification were studied at microscopic scale though Raman spectroscopy. The local melting temperature is very close to what found by DSC and by rheometry. On the other hand, crystallization onset is found at higher temperatures for long waiting times, thus considerably reducing the thermal hysteresis. Finally, we highlight a key influence of interfaces on the phase transition. Variations in boundary conditions (thermal and/or kinematical conditions) are found responsible for the way hexadecane’s solidification occurs. This strongly impacts the efficiency with which energy is generated and absorbed during the phase change and needs to be carefully taken into account when designing new thermal energy storage systems.
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- 2022
96. Optimization of selective hydrolysis of cruciferins for production of potent mineral chelating peptides and napins purification to valorize total rapeseed meal proteins
- Author
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Nastassia Kaugarenia, Sophie Beaubier, Erwann Durand, Arnaud Aymes, Pierre Villeneuve, François Lesage, Romain Kapel, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)
- Subjects
rapeseed protein valorization ,selective hydrolysis ,modelling ,economical optimization ,metal-chelating peptides ,Health (social science) ,Q70 - Traitement des déchets agricoles ,Plant Science ,Health Professions (miscellaneous) ,Microbiology ,Q52 - Traitement et conservation des aliments pour animaux ,Q02 - Traitement et conservation des produits alimentaires ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,[CHIM.OTHE]Chemical Sciences/Other ,Food Science - Abstract
International audience; Preventing oxidation and microbial spoilage are both major concerns in food industries. In this context, this study aimed to valorize the total rapeseed meal proteins with controlled enzymatic proteolysis to generate potent mineral-chelating peptides from cruciferins while keeping intact the antimicrobial napins. Implementation of proteolysis of total rapeseed protein isolate with the Prolyve® enzyme highlighted an interesting selective hydrolysis of the cruciferins. Hence, the mechanism of this particular hydrolysis was investigated through a Design of Experiments method to obtain a model for the prediction of kinetics (cruciferin degradation and napin purity) according to the operating conditions applied. Then, multicriteria optimization was implemented to maximize the napin purity and yield while minimizing both enzymatic cost and reaction time. Antioxidant assays of the peptide fraction obtained under the optimal conditions proved the high metal-chelating activity preservation (EC50 = 247 ± 27 µg) for more than three times faster production. This fraction might counteract lipid oxidation or serve as preventing agents for micronutrient deficiencies, and the resulting purified napins may have applications in food safety against microbial contamination. These results can greatly help the development of rapeseed meal applications in food industries.
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- 2022
97. Residual Microscopic Peritoneal Metastases after Macroscopic Complete Cytoreductive Surgery for Advanced High-Grade Serous Ovarian Carcinoma: A Target for Folate Receptor Targeted Photodynamic Therapy?
- Author
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Morgane Moinard, Jeremy Augustin, Marine Carrier, Elisabeth Da Maïa, Alix Penel, Jérémie Belghiti, Maryam Nikpayam, Clémentine Gonthier, Geoffroy Canlorbe, Samir Acherar, Nadira Delhem, Céline Frochot, Catherine Uzan, Henri Azaïs, Arnoux, Philippe, Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Pharmacoépidémiologie de l'AP-HP (Cephepi), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Universitaire de Cancérologie [Paris] (IUC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 (ONCO-THAI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, and Institut Universitaire de Cancérologie [Sorbonne Université] (IUC)
- Subjects
epithelial ovarian cancer ,folate receptor ,photodynamic therapy ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine ,cytoreductive surgery ,peritoneal carcinomatosis ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,gynecologic oncology - Abstract
Despite conventional treatment combining complete macroscopic cytoreductive surgery (CRS) and systemic chemotherapy, residual microscopic peritoneal metastases (mPM) may persist as the cause of peritoneal recurrence in 60% of patients. Therefore, there is a real need to specifically target these mPM to definitively eradicate any traces of the disease and improve patient survival. Therapeutic targeting method, such as photodynamic therapy, would be a promising method for such a purpose. Folate receptor alpha (FRα), as it is specifically overexpressed by cancer cells from various origins, including ovarian cancer cells, is a good target to address photosensitizing molecules. The aim of this study was to determine FRα expression by residual mPM after complete macroscopic CRS in patients with advanced high-grade serous ovarian cancer (HGSOC). A prospective study conducted between 1 June 2018 and 10 July 2019 in a single referent center accredited by the European Society of Gynecological Oncology for advanced EOC surgical management. Consecutive patients presenting with advanced HGSOC and eligible for complete macroscopic CRS were included. Up to 13 peritoneal biopsies were taken from macroscopically healthy peritoneum at the end of CRS and examined for the presence of mPM. In case of detection of mPM, a systematic search for RFα expression by immunohistochemistry was performed. Twenty-six patients were included and 26.9% presented mPM. In the subgroup of patients with mPM, FRα expression was positive on diagnostic biopsy before neoadjuvant chemotherapy for 67% of patients, on macroscopic peritoneal metastases for 86% of patients, and on mPM for 75% of patients. In the subgroup of patients with no mPM, FRα expression was found on diagnostic biopsy before neoadjuvant chemotherapy in 29% of patients and on macroscopic peritoneal metastases in 78% of patients. FRα is well expressed by patients with or without mPM after complete macroscopic CRS in patients with advanced HGSOC. In addition to conventional cytoreductive surgery, the use of a therapeutic targeting method, such as photodynamic therapy, by addressing photosensitizing molecules that specifically target FRα may be studied.
- Published
- 2022
98. Thixotropic behavior of a glass melt containing PGM particles for nuclear interest
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Pereira Machado, Norma-Maria, Neyret, Muriel, Lemaitre, Cécile, Marchal, Philippe, Département de recherche sur les Procédés et Matériaux pour les Environnements complexes (DPME), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[CHIM]Chemical Sciences - Abstract
International audience; Contrary to some other elements such as Iron, Nickel and Chromium, the Platinum Group Metals particles (PGM) are not incorporated chemically in molten glasses. These particles are generally found in nuclear borosilicate glasses resulting from the melting, at 1200°C, of a glass precursor and fission products issued from spent fuel reprocessing. During the melting step, the presence of theses metals as suspended particles of a few microns has an impact on the rheological properties of the material, leading to a Non-Newtonian behavior. Their impact on the process is the object of characterization and modeling of many studies that have established that the melt presents a shear-thinning and thixotropic behavior. At high shear rate, the glass behaves as a suspension of individual particles, whose rheological behavior is controlled by the viscosity of the vitreous matrix. On the other hand, at low shear rate, below a stress threshold, and above a certain volume fraction in PGM particles, the formation of aggregates composed of needle-like Ru/RuO2 chains and Pd-Rh-Te spherical particles, strongly influences the viscosity of the glass. In this work, a deeper analysis of the thixotropic behavior of a simulated nuclear glass melt containing 3.0 wt% (1.02 vol%) of PGM particles will be presented. Steady and transient state measurements were performed over a wide shear rate range using an imposed-stress rheometer at temperatures ranging from 1100 to 1250 °C. Using Houska model, this work shows that it is possible to predict the transient behavior of the sample from their steady-state rheological behavior.
- Published
- 2022
99. Study of the volatilization of Cesium and Rhenium in the waste vitrification process
- Author
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Sophie Schuller, Alain Ledoux, Thomas Charpin, Dominique Thomas, Caroline Michel, Laboratoire de Développement des Procédés de Vitrification (LDPV), Département de recherche sur les technologies pour l'enrichissement, le démantèlement et les déchets (DE2D), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Réactions et Génie des Procédés (LRGP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Département de recherche sur les Procédés et Matériaux pour les Environnements complexes (DPME), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Nuclear and High Energy Physics ,Materials science ,particle ,aerosol ,chemistry.chemical_element ,Scrubber ,02 engineering and technology ,rhenium ,[CHIM.INOR]Chemical Sciences/Inorganic chemistry ,010403 inorganic & nuclear chemistry ,01 natural sciences ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,Phase (matter) ,cesium ,[CHIM.CRIS]Chemical Sciences/Cristallography ,General Materials Science ,Vitrification ,waste ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,volatilization ,Volatilisation ,[CHIM.MATE]Chemical Sciences/Material chemistry ,Rhenium ,021001 nanoscience & nanotechnology ,vitrification ,0104 chemical sciences ,Aerosol ,Nuclear Energy and Engineering ,chemistry ,Chemical engineering ,13. Climate action ,Caesium ,Particle ,technetium ,0210 nano-technology - Abstract
International audience; A side effect of high level waste vitrification at 1100°C is the volatilization of radioactive cesium (Cs), recaptured further on in the process as a solid aerosol by a dust scrubber. Feedback from industry suggests that Cs combines with technetium (Tc) █ simulated here by rhenium (Re), chosen for its similar behavior █ to form volatile species. This work characterized Cs volatilization and aerosol formation. The first experiment involved elaborating and analyzing a simplified glass enriched with Cs and Re, which reinforce the volatilization phenomena. The results showed that a demixed liquid phase rich in Cs, Re, Mo, and Na formed in the liquid melt, which is reminiscent of a molybdic phase evoked in the literature. Moreover, analyzing the condensed gases led to the conclusion that the alkalis and Re volatilize congruently at around 700°C. In the second experiment, a series of measurements of the gas phase characterized aerosols throughout the process. The size distribution results showed that the particles formed in the furnace were mostly submicronic, and that the aerosols in the calciner and the dust scrubber included nanoparticles and micronic particles. SEM-EDS characterization revealed the composition of a spherical particle from the furnace made of two nested phases: one rich in Cs-Re-O, and the other rich in Na-Mo-O. The analyses performed showed that Cs and Re could be found in every particle sampled throughout the process, and that the micronic particles might originate from the aggregation of submicronic particles because of composition similarities. Thus, the observations led to a better understanding of the behavior of the elements of interest in both the melt and the gas phase.
- Published
- 2022
100. Multiphase chemical engineering as a tool in modelling electromediated reactions- example of Rh complex-mediated regeneration of NADH
- Author
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François Lapicque, Alain Walcarius, Mathieu Etienne, Wassim El Housseini, Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement (LCPME), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
- Subjects
General Chemical Engineering ,Kinetics ,010402 general chemistry ,01 natural sciences ,7. Clean energy ,Chemical reaction ,Redox ,Industrial and Manufacturing Engineering ,Chemical kinetics ,chloro(2 ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,[Cp*Rh(bpy)Cl] + ,Electrochemical regeneration ,β-nicotinamide adenine dinucleotide ,electrochemical regeneration ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,gas-liquid absorption ,Gas diffusion electrode ,010405 organic chemistry ,Chemistry ,Applied Mathematics ,gas diffusion electrode ,2′-bipyridyl) (pentamethylcyclopentadienyl)-rhodium (III) ,General Chemistry ,electromediated reactions ,0104 chemical sciences ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,flow reactor ,Chemical engineering ,reaction kinetics ,NAD+ kinase ,Beta-nicotinamide adenine dinucleotide hydrate ,Hydrate ,[CHIM.OTHE]Chemical Sciences/Other - Abstract
International audience; Beta-nicotinamide adenine dinucleotide (NAD + /NADH) is an important enzymatic co-factor that can be efficiently regenerated using a rhodium-based catalyst as electron transfer mediator (i.e. [Cp*Rh(bpy)Cl] + , where Cp* = pentamethylcyclopentadienyl and bpy = 2,2-bipyridine). Here, the above mediated regeneration of NADH is implemented in a redox flow bioreactor hybridized with a gas diffusion electrode for hydrogen oxidation. The reactor was initially optimized with respect to rhodium complex and NAD + concentrations, humidification of the hydrogen gas, flow rates of both H 2 gas and electrolytic solution, and solution pH. The integration of an enzymatic reaction consuming the generated NADH was then investigated in a flow process, combining in series the electrochemical reactor to a biochemical cell with immobilized L-lactic dehydrogenase for the conversion of pyruvate to lactate. A high activity was achieved with a turnover number up to 370 h-1 for NADH regeneration. Coupled electrochemical regeneration to enzymatic reaction led to total turnover number values of 2000 and 6.3*10 6 for NADH electrochemical regeneration and bioconversion, respectively.
- Published
- 2022
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