51. Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis
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Farès Moustafa, Jeannot Schmidt, Jean-Baptiste Bouillon-Minois, Marion Trousselard, Damien Bouvier, Frédéric Dutheil, Amanda C. Benson, David Thivel, Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), CHU Clermont-Ferrand, Institut de Recherche Biomédicale des Armées (IRBA), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Swinburne University of Technology [Melbourne], Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Service Santé Travail Environnement [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, WittyFit, Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), and LAPSCO, HAL
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Leptin ,medicine.medical_specialty ,Time Factors ,media_common.quotation_subject ,Population ,[SHS.PSY]Humanities and Social Sciences/Psychology ,030209 endocrinology & metabolism ,Review ,White adipose tissue ,Overweight ,[SHS.PSY] Humanities and Social Sciences/Psychology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,TX341-641 ,education ,030304 developmental biology ,media_common ,0303 health sciences ,education.field_of_study ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Nutrition and Dietetics ,Nutrition. Foods and food supply ,business.industry ,public health ,Appetite ,medicine.disease ,anxiety ,Obesity ,Endocrinology ,appetite ,Meta-analysis ,Regression Analysis ,Biomarker (medicine) ,medicine.symptom ,business ,metabolism ,Biomarkers ,Stress, Psychological ,mental health ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Food Science - Abstract
International audience; Background: Leptin is a satiety hormone mainly produced by white adipose tissue. Decreasing levels have been described following acute stress. Objective: To conduct a systematic review and meta-analysis to determine if leptin can be a biomarker of stress, with levels decreasing following acute stress. Methods: PubMed, Cochrane Library, Embase, and ScienceDirect were searched to obtain all articles studying leptin levels after acute stress on 15 February 2021. We included articles reporting leptin levels before and after acute stress (physical or psychological) and conducted random effects meta-analysis (DerSimonian and Laird approach). We conducted Meta-regressions and sensitivity analyses after exclusion of groups outside the metafunnel. Results: We included seven articles—four cohort and three case-control studies—(28 groups) from 27,983 putative articles. Leptin levels decreased after the stress intervention (effect size = −0.34, 95%CI −0.66 to −0.02) compared with baseline levels, with a greater decrease after 60 min compared to mean decrease (−0.45, −0.89 to −0.01) and in normal weight compared to overweight individuals (−0.79, −1.38 to −0.21). There was no difference in the overweight population. Sensitivity analyses demonstrated similar results. Levels of leptin after stress decreased with sex ratio—i.e., number of men/women—(−0.924, 95%CI −1.58 to −0.27) and increased with the baseline levels of leptin (0.039, 0.01 to 0.07). Conclusions: Leptin is a biomarker of stress, with a decrease following acute stress. Normal-weight individuals and women also have a higher variation of leptin levels after stress, suggesting that leptin may have implications in obesity development in response to stress in a sex-dependent manner.
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- 2021
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