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Background and objective The 4-item Psoriatic Arthritis Uncluttered Screening Evaluation (PURE-4) questionnaire is a useful tool for identifying patients with suspected psoriatic arthritis before referring them to a rheumatology department for confirmation. The original English version has good discriminant validity (sensitivity, 85.7%; specificity 83.6%). We aimed to produce an adapted Spanish version of the PURE-4 for validation and use in Spain. Material and method We applied the method recommended by the International Society for Pharmacoeconomic and Outcome Research for the cultural adaptation of patient-centered measurement tools. The phases in the processes involved forward translation, reconciliation, back translation review, harmonization, cognitive debriefing and review, and proofreading. Results We obtained the permission of the author of the original questionnaire. Two native-speaking translators translated the questionnaire into Spanish. Small changes, mainly in the way the items were expressed, were then made in order to reconcile the 2 translations. The questionnaire was then back translated to English and revised to achieve a version equivalent to the original. A Spanish translation derived from the revision was tested for understandability in 7 patients, and the final Spanish version was then produced. During the translation phases, the project manager and a scientific committee made up of a dermatologist and a rheumatologist reviewed the different versions. Team members exchanged information throughout the process, providing for harmonization and the quality control that guaranteed conceptual equivalence. Conclusions This adaptation of the PURE-4 questionnaire for use in Spain has been the first step toward using it in routine clinical practice. The standardized method we used ensures that the Spanish and the original versions are equivalent.

Resumen Antecedentes y objetivo El cuestionario 4-item Psoriatic arthritis UnclutteRed screening Evaluation (PURE-4) puede considerarse una herramienta util para identificar pacientes con posible artritis psoriasica y derivarlos al servicio de reumatologia para confirmar el diagnostico. La version original en ingles presenta alta validez discriminatoria (85,7% de sensibilidad, 83,6% de especificidad). El objetivo de este trabajo es adaptarlo para poblacion espanola como paso previo a su validacion. Material y metodo Se aplico la metodologia recomendada por la International Society Pharmacoeconomic and Outcome Research (ISPOR) para adaptaciones culturales de medidas centradas en el paciente. Fases: preparacion, traduccion, reconciliacion, retrotraduccion/revision, armonizacion, test de comprension/revision, correccion de pruebas. Resultados En la preparacion se obtuvo el permiso del autor del cuestionario original. Dos traductores nativos realizaron la traduccion del cuestionario original al espanol. En la reconciliacion se realizaron pequenas modificaciones, principalmente en el enunciado de los items. Se realizo retrotraduccion al ingles, logrando una version equivalente al cuestionario original. La version espanola derivada se administro en el test de comprension a 7 pacientes, obteniendose la version final en espanol. Durante las traducciones, el responsable del proyecto y un comite cientifico formado por un dermatologo y un reumatologo revisaron las diferentes versiones. Los intercambios de informacion entre el equipo durante todo el proceso integraron la fase de armonizacion, siendo un control de calidad continuo que garantizo la equivalencia conceptual de las traducciones. Conclusiones La adaptacion del cuestionario PURE-4 para poblacion espanola constituye la primera etapa para su uso en practica clinica habitual. La metodologia estandarizada garantiza la equivalencia entre la version espanola y la original.

Background Polymorphous adenocarcinoma (PAC) is a rare malignant tumor of the minor salivary glands. It has an infiltrative growth, variable architectural patterns, neurotropism and cellular monomorphism. Approximately 75% of the cases show a specific mutation in the protein kinase D1 (PRKD1) gene. Reflecting the rarity of the tumor and intraoral location, the cytologic experience is limited with few reported series. In this study we analyze our cytologic experience to determine if a preoperative diagnosis is possible. Methods A retrospective study of 11 patients with PAC in which a cytologic study was available. A review of the literature was also performed. Results Our study shows that PAC has relatively constant cytological features. The analysis of the cytological literature although it shows some heterogeneity, also reveals repetitive cytological findings. Smears are cellular with irregular groups some showing pseudopapillary branching morphology. Monolayered clusters and small acinar structures are also present. Most cases have small metachromatic globules embedded within the groups determining a cylindromatous pattern. Tumoral cells are small and uniform with scarce to moderate cytoplasm. Nuclei are round and oval with occasional grooves and small nucleoli. Conclusion PAC has characteristic cytological features that together with its location in minor salivary gland must make us consider it preoperatively. It may resemble basal cell adenoma and epithelial-rich pleomorphic adenoma so we should be cautious in the final diagnosis. Whenever possible, the characteristic cytomorphology of PCA should make us evaluate the mutational status of PRKD1 gene since it may permit a more accurate diagnosis.

Altres ajuts: acords transformatius de la UAB Data on the effectiveness and safety of a drug in real-world clinical practice complement the evidence from clinical trials, which are carried out in a different setting. Little has been published on the effectiveness and safety of guselkumab in the treatment of psoriasis in clinical practice. The ojective of this study was to assess the effectiveness and safety of guselkumab at 24 weeks in patients with moderate to severe plaque psoriasis in routine clinical practice. A retrospective, multicentre study of adult patients with moderate to severe plaque psoriasis treated with guselkumab for at least 24 weeks was carried out in Spain. We studied 343 patients, 249 of whom were followed for 24 weeks. By week 24, the mean (SD) psoriasis area severity index (PASI) had decreased from 11.1 (7.3) to 1.7 (2.8) (−9.3; [−10.2;-8.4]), 85.9% of the patients had achieved PASI score of 4 or less and 77.9% a PASI score of 2 or less. In terms of relative PASI response, 59.4% of the patients achieved a PASI-90 response and 49.0% a PASI-100 response. On multivariate analysis, two factors reduced the probability of a PASI of 2 or less at 24 weeks: a BMI ≥30 (OR, 0.44; 95% CI, 0.22-0.88) and a greater previous exposure to biologic therapy (OR, 0.69; 95% CI, [0.56-0.84]). Adverse events were rare (9.9%) and led to withdrawal from treatment in only nine patients (2.6%) by the end of the follow-up period. The results of this study confirm the high efficacy and safety of guselkumab indicated by the clinical trial data. In clinical practice, the absolute PASI score appears to be a better marker of response to treatment than the relative value.

Background Guselkumab is indicated for moderate-to-severe plaque psoriasis. Data from real-life clinical practice regarding its use are scarce, especially concerning patients who relapse after previous biologic therapies. Aim This study aimed to evaluate the effectiveness, safety, and adherence to guselkumab in psoriasis refractory to biologic therapies. Method This real-life, retrospective study included patients who initiated guselkumab between February 2019 and October 2020. The main objective was to assess effectiveness, expressed as the psoriasis area and severity index (PASI) = 90%. The MPR was not associated with PASI score at first follow-up. Conclusion Our study supports evidence that guselkumab is an effective and safe drug in psoriasis refractory to biologic therapies. Adherence to treatment is not related to effectiveness, suggesting that, in some cases, the interval between doses could be increased.

Psoriatic arthritis (PsA) is a type of inflammatory arthritis that is included within the spondyloarthritis, a group of rheumatological diseases characterized by different clinical manifestations and associated comorbidities, that can compromise the quality of life of patients. The diagnosis of PsA is sometimes difficult due to an enormous clinical and radiological variability, including six different domains of involvement: peripheral joint, axial skeleton, skin psoriasis, nail psoriasis, enthesitis and dactylitis. Currently, there are no biomarkers that allow the detection of PsA in patients with psoriasis, so a high level of suspicion is important, mainly by dermatologists, but also by other specialists, such as family doctors. Advances in the knowledge of new immunological mechanisms and joint management by rheumatologists and dermatologists have made it possible to improve the therapeutic approach in patients with PsA.

Este trabajo fin de grado es el inicio de una investigación sobre el arco adintelado en los portales de Madrid. Se centra en la catalogación de algunos de los ejemplos más destacados de la ciudad a lo largo de los siglos XVI al XIX. Para entender mejor esta clasificación se abordan temas relacionados con el comportamiento mecánico del arco y el dintel en sí mismos. Esto nos ayudará a comprender el funcionamiento del dintel y las derivaciones patológicas asociadas a esta mecánica. Por otra parte, resulta imprescindible el estudio de la tratadística, para relacionar los casos reales catalogados con la teoría planteada por algunos autores de la época.

Two successive experiments have been carried out to assess the influence of three oils rich in ü)3 fatty acids on the nutritional and organoleptic qualities of broiler chicken meat. A basal diet enriched with 8.2% Fish Oil (FO) was fed to one group ofbirds throughout the whole growth period (Tl); this basal diet was replaced by another supplemented with 8.2% Linseed Oil (LO) instead of FO (exp 1), and Rapeseed Oil (RO, exp II) for three different periods: the last week (T2), the last two weeks (T3) and the whole experiment (T4). The experimental diets were formulated to be isonitrogenous (25% CP) and isocaloric (3200 Kcal EM / kg)and were fedadlibitum to birds until slaughteringat the age of35 days. Performance parameters and processing yields were reported at the time. More¬ over, the sensory evaluation ofchicken meat quality was conductedand the other meat quality traits were determined.Afterprocessing, lyophilizingand storingat -20°C, the fatty acid profile of meat samples from both experiments was conducted. Thigh samples provided the most accurate reflection ofthe fattyacid profileof diets. Removing FO resulted in progressively lower values of SATurated fatty acids and higher total w6 fatty acid content, because ofthe rise in linoleic acid (LA, C18:2co6) in both experiments. Treatments including larger amounts ofLA for longer periods (T4) showed minimal decrease in tissue concentration of desaturation and elongation products ofthis acid (C20 series). The amounts of most 0)3 fatty acids (CI8:4, C20;5, C22;5, C22:6) were significantly reduced with the suppression ofFish oil. However, replacing FO by LO resulted in mini¬ mal effects on total 0)3 fatty acids, mainly due to the rise ofC18:3 (linolenic acid, LNA). Nevertheless, replacing FO by RO resulted in the fall ofthe total 0)3 fatty acid content of meat samples, since the minor increase in LNA could not com¬ pensate for the depression of the other 0)3 fatty acids, present in considerable amounts in fish oil diets. On the other hand, in the second experiment, levels of snssiON Ml -44 74 ; monounsaturated fatty acids (MUFA) were increased, due to the larger amounts ofoleic acid (CI 8: l(i)9). ; Grades for organoleptic quality awarded the meat from treatments withoutfish oil (T4) by sensory panelists were significantly higher in both experiments.

The concept of "tigroid" background is used in cytology to describe a peculiar smear background characterized by the presence of a relatively granular, reticulated material that was described as "foamy, lazy, tiger-striped or astrakhan". It was used to describe the background seen in smears obtained from seminoma. In addition to seminoma, we now know that it can be present in different tumours, mostly carcinomas and round cell sarcomas. These share with seminoma a cytoplasm with high glycogen content and many times clear cell morphology. The "tigroid" background is seen when smears are air-dried and Romanowsky-based stains are used (May-Grunwald-Giemsa and Diff-Quik stains). It is only seen in fine needle aspiration or intraoperative squashing or scrapping samples, but not in specimens obtained from effusions or liquid-based cytology. Wet-fixed cytologic samples with alcohol or with formaldehyde tend to dissolve the background so it is not usually present in Papanicolaou stained smears. In this review, we discuss tumours in which the "tigroid" background is observed and its potential diagnostic utility and aetiology. It is interesting to remark that except for parathyroid adenoma and adenomatoid tumour all the neoplasms in which this background has been observed are malignant.

An experiment was conducted to assess the effect ofsupplying with fish or linseed oils on the performance, quality parameters and fatty acid (FA) composition of the meat of broiler chickens. Besides, it aimed to test the relative stability of the FA composition after cooking of the chicken meat. A diet with 4% of tallow plus 4% linseed oil (Tl ) or 4% fish oil (T2) was fed to the birds throughout the 5 wk growth period. After slaughtering of the animals, the FA profile of the raw samples was determined by means of gas chromatography, and also alter cooking in a convector oven (180"C, 35 min). Carcass yield, percentage of valuable parts, texture, juiciness and grill losses of meat were determined as objective quality parameters. Performance parameters were not significantly different among treatments, though a tendency towards a better transformation index was found in Tl fed animals (p

10 pages, 4 figures, In this chapter, we describe a rapid workflow for the shotgun global phosphoproteomics analysis. The strategy is based on the use of accelerated in-solution trypsin digestion under an ultrasonic field by high-intensity focused ultrasound (HIFU) coupled to titanium dioxide (TiO2) selective phosphopeptide enrichment, fractionation by strong cation exchange chromatography (SCX), and analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in a high-resolution mass spectrometer (LTQ-Orbitrap XL). The strategy was optimized for the global phosphoproteome analysis of Jurkat T-cells. Using this accelerated workflow, HIFU-TiO2-SCX-LC-MS/MS, 15,367 phosphorylation sites from 13,029 different phosphopeptides belonging to 3,163 different phosphoproteins can be efficiently identified in less than 15 h, This work was supported by the EU Marie Curie actions (FP7-PEOPLE-2012-IEF, ref. 332274), by the Ramon Areces Foundation (XVII National grant), by the GAIN-Xunta de Galicia Project (IN607D 2017/01) and by the Spanish AEI/EU-FEDER (PID2019-103845RB-C21) project

Monográfico: Las redes sociales en la ciencia., [ES]: Esta investigación se enmarca en los estudios sociométricos de literatura científica. En concreto en la aplicación del análisis de redes a la colaboración científica y las pautas de citación entre investigadores para comparar tres áreas temáticas: psiquiatría, psicología general y psicología experimental. Los objetivos son aplicar el análisis de redes para acotar universos de conocimiento independientes pero lo suficientemente próximos y relacionados como para estudiarlos en paralelo, buscar sus similitudes y diferencias en base a los indicadores bibliométricos y de red obtenidos. Se concluye que el análisis de redes aplicado a los sistemas de clasificación de las bases de datos es útil para acotar universos de conocimiento que trascienden los propios sistemas de clasificación siempre más simplistas; que los gráficos de redes permiten objetivar grupos de trabajo y dinámicas en ellos que de otro modo sería difícil descubrir, para ello resulta además especialmente útil superponer las redes de colaboración con las de citas puesto que las primeras representan relaciones explícitas y las segundas relaciones implícitas, pero ambas sirven para posicionar autores y grupos entre sí. Finalmente, se apunta la necesidad de una flexibilización en los indicadores de seguimiento y evaluación de las diferentes áreas científicas, que tenga en cuenta las características propias de las diversas disciplinas, también la idoneidad de la obtención de nuevos indicadores basados no tanto en la producción de autores estudiados unitariamente como su capacidad de intermediación con otros actores, es decir, de articulación del sistema de investigación., [EN]: This research is framed in sociometric studies above bibliography. In particular, in the application of social Networks to co authorship, and the patterns of citation between researchers, focused in comparison of Psychiatry and Psychology and areas. The objectives are: the application of social network analysis to retrieval information in a multidisciplinary database, due to subject headings lists are considered to be insufficient and inflexible to describe relationship between sciences; and the establishment of similarities and differences between the three areas according to bibliometric and network indicators. The Social Network analysis used in this work to select scientific articles of a discipline avoids the rigidity of retrieval information based in a preselected set of subjects that never explains the overlapping and that could to mutilate extensions of some of them or just simply to produce silence before incipient relations. Also, network graphs show working groups that otherwise would be difficult to discover. In addition, it is especially useful to superpose networks of co authorship with those of cited references patterns because the first represent explicit relations and the second one represent implicit relations, but both serve to compare each author or group to the others. And finally, the necessity of an adaptation of the monitoring and evaluation indicators of the different scientific areas is indicated, which considers the own characteristics of the diverse disciplines, and they must be based not as much in the productivity of authors studied unitarily as its capacity of intermediation with other actors and their capacity of articulation of the research system.

El principal objetivo del presente Trabajo Fin de Máster (TFM) es localizar posibles regiones candidatas con asociación a características físicas de calidad de las semillas como el peso, el color o la presencia de hilio. Empleando para ello una caracterización exhaustiva realizada en 1.518 accesiones de los géneros Cucurbita y Citrullus y los datos genómicos disponibles en CuGenDB (http://cucurbitgenomics.org/). Este objetivo general se aborda desde los siguientes objetivos específicos: Realizar una caracterización de al menos 6 semillas por accesión en 805 accesiones de Cucurbita spp. y 713 accesiones de Citrullus spp. Los caracteres de interés serán: tamaño, peso y color de las semillas. Empleando el programa Tassel5 (https://www.maizegenetics.net/tassel), contrastar los datos fenotípicos de las 1.518 accesiones con los datos genómicos para realizar estudios de asociación (GWAS). Por medio de los métodos General Lineal Model (GLM) y Mixed Lineal Model (MLM) se designarán variantes con potencial asociación con el carácter en estudio. En caso de detectar asociación, comparar los resultados en los distintos análisis con estudios previos con el fin de determinar la relevancia de las distintas regiones detectadas. Empleando las anotaciones del genoma disponibles para C. pepo, C. maxima y C. lanatus comprobar el impacto de las variantes exónicas en la proteína.

En este trabajo se realiza un seguimiento de las medidas de política monetaria que se han aplicado en el siglo XXI por parte del Banco Central Europeo y sus principales repercusiones.El transcurso de estos años no ha sido nada fácil, el BCE ha tenido que hacer frente a tres grandes crisis económicas que han llegado a poner en peligro la supervivencia de la economía de varios países miembros. El nivel de precios se ha mantenido durante largos periodos por debajo del objetivo y los tipos de interés oficiales tuvieron que ser reducidos hasta su mínimo tras la crisis financiera y a día de hoy todavía no han aumentado. Además, las incesantes políticas aplicadas para mantener la economía con vida, han generado que el BCE haya aumentado sobrenaturalmente la cantidad de activos en su balance.En el momento actual, analizamos los retos a los que se enfrenta el BCE en los próximos años. La autoridad monetaria debe enfrentarse al menos a tres grandes retos: la baja inflación que ha venido arrastrando la economía previamente con el temor de que se convierta en una inflación demasiado elevada con la reactivación de la economía post-pandemia, a los tipos de interés que se encuentran en sus mínimos debido sobre todo a factores demográficos y económicos que les dejan apenas sin margen de actuación y, por último, al gran tamaño de balance que ha ido acumulando con las crisis sucesivas, especialmente con la de la pandemia, y a los elevados riesgos que plantea tanto su mantenimiento como su reducción progresiva.

The cinema has generated the great history integrated by many elements: social works, events, professions, etc. In order to document its history, Databases on cinema are helpful.

Objetivo: Determinar la mejora objetiva y subjetiva de la calidad visual tras la realización de la capsulotomía en pacientes con opacidad capsular posterior (OCP) utilizando el sistema de imágenes de retina de doble paso, la medida de la agudeza visual (AV) y el cuestionario de calidad de vida VF-14. Método: Se valoraron 36 ojos de 23 pacientes con OCP sin alteraciones en el fondo de ojo o corneales, ni ojo seco. Antes y después de la capsulotomía se evaluó la AV con la mejor corrección, respondieron el test VF-14 y se exploró la calidad visual objetiva con el HD Analyzer (HDA), midiendo los parámetros OSI, MTF y Strehl ratio. Se compararon los resultados con los de un grupo control de pacientes tras intervención de cataratas. El análisis estadístico se realizó con el SPSS 22.0. Resultados: Se encontraron correlaciones significativas entre los parámetros objetivos y subjetivos de los pacientes antes de la capsulotomía. La correlación antes de la capsulotomía entre OSI y AV fue de r = 0,481 (p = 0,003) y entre AV y el test VF-14 de r = -0,449 (p = 0,006). Se encontró una diferencia estadísticamente significativa en parámetros objetivos y subjetivos entre el grado 1 y 2 de opacidad, a diferencia de otros grados de opacidad. No se encontró correlación entre el tiempo tras la cirugía de cataratas y el desarrollo de la OCP. No se encontraron diferencias en la calidad óptica entre los pacientes post-capsulotomía y los pacientes del grupo control. Conclusiones: Los parámetros obtenidos con el HDA son útiles como criterio para decidir intervenir de capsulotomía a un paciente con OCP. Puede asegurarse que tras la capsulotomía la calidad óptica es similar a la que se obtiene inmediatamente tras la cirugía de cataratas

Treball Final de Grau en Psicologia. Codi: PS1048. Curs: 2019/2020 Pornography has been more available since the arrival of the Internet, broadband networks and smartphones. Pornography exposure may lead to negative psychological and behavioral consequences. Besides, sexual assertion plays a role against risky sexual behaviour, sexual abuse and victimization. The aim of this study is to analyze the relation between wanted and unwanted exposure to pornography and sexual assertion. La pornografía se ha vuelto más accesible desde la llegada de internet, la banda ancha y los teléfonos inteligentes. La exposición a la pornografía puede tener consecuencias psicológicas y conductuales negativas. Por otra parte, la asertividad sexual actúa como factor de protección ante conductas sexuales de riesgo, abusos y victimización sexual. El objetivo del presente trabajo es analizar la relación entre la voluntaria e involuntaria exposición a la pornografía y la asertividad sexual.

Objective.To reach a consensus on the instruments to be used in clinical practice to evaluate the effectiveness of biological disease-modifying antirheumatic drug (bDMARD) treatment in patients with psoriatic arthritis (PsA) in the short to medium term (3–6 mos), and to establish the minimum health outcomes for treatment continuation.Methods.A 2-round Delphi questionnaire was developed based on both the information gathered in the literature review and 4 discussion groups. The suitability and feasibility of the proposed sets of instruments were assessed on a 7-point Likert scale. Consensus was established when at least 75% of healthcare professionals (HCP) reached agreement. To define a minimum health outcome to continue treatment, a combination of 4 disease activity states and 3 health-related quality of life states were defined for 3 hypothetical patient profiles. HCP were given a dichotomous choice (yes/no) to respond to whether they would continue treatment in each case.Results.The second round was completed by 106 HCP. Consensus was reached on the use of (1) Disease Activity in Psoriatic Arthritis + Psoriatic Arthritis Impact of Disease (PsAID12) or minimal disease activity + PsAID12 + C-reactive protein, in peripheral PsA; and (2) Ankylosing Spondylitis Disease Activity Score + PsAID12, in axial PsA. Health outcomes considered sufficient to continue treatment were stricter for bDMARD-naive patients than for patients who failed several bDMARD.Conclusion.To the best of our knowledge, this is the first multidisciplinary consensus on a set of outcomes for the evaluation of bDMARD effectiveness in PsA, in routine clinical practice.

Background: Scant information from clinical practice is available on the effectiveness and safety of ustekinumab (UST) 90 mg in patients with psoriasis weighing 100 kg or less. Objectives: To assess the effectiveness and safety at weeks 16 and 24 of UST 90 mg in patients with psoriasis weighing

Resumen. Antecedentes y objetivo: El cuestionario 4-item Psoriatic arthritis UnclutteRed screening Evaluation (PURE-4) puede considerarse una herramienta útil para identificar pacientes con posible artritis psoriásica y derivarlos al servicio de reumatología para confirmar el diagnóstico. La versión original en inglés presenta alta validez discriminatoria (85,7% de sensibilidad, 83,6% de especificidad). El objetivo de este trabajo es adaptarlo para población española como paso previo a su validación. Material y método: Se aplicó la metodología recomendada por la International Society Pharmacoeconomic and Outcome Research (ISPOR) para adaptaciones culturales de medidas centradas en el paciente. Fases: preparación, traducción, reconciliación, retrotraducción/revisión, armonización, test de comprensión/revisión, corrección de pruebas. Resultados: En la preparación se obtuvo el permiso del autor del cuestionario original. Dos traductores nativos realizaron la traducción del cuestionario original al español. En la reconciliación se realizaron pequeñas modificaciones, principalmente en el enunciado de los ítems. Se realizó retrotraducción al inglés, logrando una versión equivalente al cuestionario original. La versión española derivada se administró en el test de comprensión a 7 pacientes, obteniéndose la versión final en español. Durante las traducciones, el responsable del proyecto y un comité científico formado por un dermatólogo y un reumatólogo revisaron las diferentes versiones. Los intercambios de información entre el equipo durante todo el proceso integraron la fase de armonización, siendo un control de calidad continuo que garantizó la equivalencia conceptual de las traducciones. Conclusiones: La adaptación del cuestionario PURE-4 para población española constituye la primera etapa para su uso en práctica clínica habitual. La metodología estandarizada garantiza la equivalencia entre la versión española y la original.

Psoriatic arthritis is a common type of inflammatory arthritis found in up to 40% of patients with psoriasis. Because skin involvement usually precedes joint involvement, dermatologists play a key role in early detection. Early diagnosis is important for reducing the risk of irreversible structural damage, attenuating the deterioration of physical function, and improving patients' quality of life. This consensus statement was drafted by a group of 9 dermatologists and 1 rheumatologist to provide simple recommendations to help dermatologists screen for psoriatic arthritis in patients with psoriasis. The experts offer consensus-based guidelines that draw on a review of available scientific evidence and on experience acquired in routine clinical practice.

Resumen La artritis psoriasica (APs) es una forma comun de artritis inflamatoria que aparece hasta en el 40% de los pacientes con psoriasis. Dado que la afectacion cutanea suele preceder a la afectacion articular, los dermatologos desempenan un papel fundamental en la deteccion precoz de la APs. El diagnostico precoz es importante para reducir el riesgo de danos estructurales irreversibles, limitar el deterioro de la funcion fisica y mejorar la calidad de vida de los pacientes. El presente documento ha sido elaborado por un grupo de especialistas (nueve dermatologos y un reumatologo) con el objetivo de proporcionar recomendaciones sencillas que ayuden a los dermatologos en el cribado de la APs en pacientes con psoriasis. Los expertos elaboraron el presente documento ofreciendo unas recomendaciones consensuadas basadas en una revision descriptiva de la evidencia cientifica disponible y en la experiencia adquirida en la practica clinica diaria.

Background Ixekizumab (anti-IL17A) is effective as treatment for moderate-to-severe plaque psoriasis, but real-life data on effectiveness and safety are currently very limited. Objective To evaluate the efficacy and safety of ixekizumab in a cohort of real-life plaque psoriasis patients. Methods Retrospective chart review of 100 patients with moderate-to-severe plaque psoriasis treated with ixekizumab at seven Spanish dermatological centres. Results According to the as observed analysis, the percentage of patients achieving a 75% and 90% of reduction from the baseline score of Psoriasis Area and Severity Index (PASI) was 87.5%-50.0% at week 12-16; 88.3%-58.4% at week 24 and 82.9%-58.5% at week 52, respectively. The mean +/- standard deviation (SD) score of PASI at baseline was 12.9 +/- 9.2, and it declined rapidly after ixekizumab administration to 1.9 +/- 4.0 (P < 0.001) at week 12-16 and was maintained at 1.7 +/- 4.1 and 1.8 +/- 2.9 at week 24 and 52, respectively. Ixekizumab response was not affected by clinical variables like body mass index, disease duration or the presence of psoriatic arthritis. However, the bio-naive group showed significantly higher PASI 75 response rate at week 12-16 compared to patients previously exposed to biologic agents (P = 0.037). Twenty-six (26%) patients experienced adverse events (AEs) during the follow-up period, being most of them of mild-to-moderate intensity. The most common AE was local reaction at the site of injection (14/26; 53.8%). At the end of the observational period, 15 (15%) patients discontinued ixekizumab treatment due to limited clinical improvement (n = 11), adverse events (n = 3) or lost to follow-up (n = 1) within a mean +/- SD time of 6.0 +/- 3.9 months. Conclusion The present study illustrates the initial experience with ixekizumab in real-world clinical practice confirming its usefulness and safety in the management of plaque psoriasis patients.

Background Nail psoriasis disease is associated with an increased probability of psoriatic arthritis, and its clinical signs may have different correlates with the pathogenesis of adjacent bone destruction and have different prognostic value. Recent publications about psoriasis and nail psoriatic disease describe different ultrasonographic findings but the relationship between these ungueal alterations measured by ultrasonography and the presence of enthesopathy of the extensor digitorum has yet to be discovered. Objective To describe which ultrasonographic characteristics of nail psoriasis are associated with the presence of subclinical enthesopathy in patients with PsO and asymptomatic PsA. Methods Patients with psoriasis and asymptomatic psoriatic arthritis were included in the prospective study. Demographic, clinical data and PASI and NAPSI indexes were recorded of all the patients in the assessment visit. The US assessment included Achilles tendon, extensor digitorum tendon and US scan of the nail plate, nail matrix, nail bed and adjacent skin over nail matrix of the five nails of each hand. Results Forty-eight patients were included in the study; 33 of them presented ultrasound evidence of extensor digitorum tendon enthesopathy. Nails of the patients with subclinical enthesopathy had a higher NAPSI and skin thickness than the nails of the patients without subclinical enthesopathy (P = 0.047). Patients with asymptomatic enthesopathy had significantly thicker proximal nail folds (1.44 ± 0.312 vs. 1.23 ± 0.27, P = 0.023). Nail beds and matrices were also thicker but the differences were not statistically significant (1.77 ± 0.27 vs. 1.74 ± 0.21, P = 0.66, and 1.79 ± 0.28 vs. 1.67 ± 0.19, P = 0.10, respectively). No statistically significant differences in the trilaminar structure were found between both groups. Patients with and without asymptomatic enthesopathy of extensor digitorum tendons did not statistically differ as regards ultrasonographic alterations of the Achilles tendons (60.6% vs. 46.4%, P 0.368). Conclusion Enthesopathy abnormalities can be detected by US in patients with psoriasis without musculoskeletal complaints frequently. There is a close relationship between subclinical enthesopathy of the extensor digitorum tendon and the presence of nail alterations. Further studies are required to research what implications have the presence of these ungual alterations measured by US, and how it affects later development of a PsA.