963 results on '"López-Calderón A"'
Search Results
52. Efecto del ciclo de producción sobre el potencial de rendimiento y calidad nutricional del maíz forrajero en la Comarca Lagunera
- Author
-
Jorge Alberto Granados-Niño, Juan Isidro Sánchez-Duarte, Esmeralda Ochoa-Martínez, Karla Rodríguez-Hernández, David Guadalupe Reta-Sánchez, and Magali Jeaneth López-Calderón
- Subjects
General Medicine - Abstract
El objetivo de este estudio fue evaluar el efecto del ciclo de producción sobre el potencial de rendimiento y calidad nutricional del maíz forrajero en la Comarca Lagunera. El experimento se estableció en el Campo Experimental-INIFAP. Se utilizó el híbrido de maíz SB-302 en los ciclos agrícolas de primavera y verano bajo un diseño de bloques completamente al azar con cuatro repeticiones durante 2018, 2020 y 2021. La información se analizó con el PROC MIXED de SAS usando el ciclo agrícola como un efecto fijo y el año como efecto aleatorio. Se evaluaron los rendimientos de forraje verde (RFV) y seco (RFS), materia seca (MS), proteína cruda (PC), fibra ácido detergente (FDA), fibra neutro detergente (FDN), digestibilidad in vitro de la FDN a las 30 horas de incubación (DFDN-30 h), energía neta de lactancia (ENL), almidón y lignina, producción potencial de leche por tonelada y por hectárea y rendimientos de FDN, DFDN-30 h y ENL, almidón y lignina. El RFV y RFS fueron mayores en primavera que en verano por 8.8 y 3.7 t ha-1, respectivamente. El ciclo de producción no afectó la MS, FDN, ENL, almidón y lignina. Sin embargo, para el ciclo de primavera los contenidos PC, FDA y DFDN-30 h fueron mayores que en el verano con 0.57, 1.98 y 7.87%, respectivamente. Además, la producción potencial de leche por tonelada y los rendimientos de FDN, DFDN-30 h y ENL fueron superiores en primavera que en verano. En general, el maíz sembrado en primavera presentó mayores rendimientos de forraje por hectárea y mejor digestibilidad de la fibra que el maíz sembrado en verano en la Comarca Lagunera.
- Published
- 2022
53. Composición nutritiva y productividad de forrajes alternativos de otoño-invierno en diferentes fechas de siembra del norte de México
- Author
-
Anabel Guadalupe López-Jara, David Guadalupe Reta-Sánchez, Arturo Reyes-González, Omar Iván Santana, Magali Jeaneth López-Calderón, and Juan Isidro Sánchez-Duarte
- Subjects
General Medicine - Abstract
El objetivo de este estudio fue evaluar la composición nutritiva y la productividad de forrajes alternativos en diferentes fechas de siembra. Lo forrajes alternativos fueron canola y cártamo y los tradicionales fueron cebada y triticale. Las cuatro fechas de siembra fueron: 16 de noviembre, 7 de diciembre, 28 de diciembre y 18 de enero, durante dos años. Al comparar con cebada y triticale, la canola y el cártamo tuvieron menor fibra detergente neutro (FDN) y mayor proteína cruda (PC), pero similar energía neta para lactancia (ENL). La fecha de siembra tuvo poco impacto en la composición nutritiva de estos forrajes, pero el rendimiento de nutrientes fue afectado significativamente. Los rendimientos de materia seca (MS), PC y ENL decrecieron al retrasar la fecha de siembra en todas las especies. Canola, cártamo y cebada presentaron los mayores rendimientos de nutrientes el 16 de noviembre y 7 de diciembre, mientras que en triticale se presentaron entre el 16 de noviembre y 28 de diciembre. Cebada y triticale produjeron los rendimientos más altos de MS y ENL en todas las fechas de siembra, ambas especies mostraron el mayor rendimiento de FDN en las tres primeras fechas de siembra durante los dos años. En conclusión, la siembra temprana mejora la composición nutritiva y la productividad en canola y cártamo, por ello, estos cultivos representan una buena opción como forraje alternativo sembrado a finales de noviembre o principios de diciembre en el norte de México.
- Published
- 2022
54. IGF-1 and IGFBP-3 in Inflammatory Cachexia
- Author
-
Ana Isabel Martín, Teresa Priego, Álvaro Moreno-Ruperez, Daniel González-Hedström, Miriam Granado, and Asunción López-Calderón
- Subjects
GH ,IGF-1 ,IGFBP-3 ,sepsis ,inflammation ,muscle wasting ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Inflammation induces a wide response of the neuroendocrine system, which leads to modifications in all the endocrine axes. The hypothalamic–growth hormone (GH)–insulin-like growth factor-1 (IGF-1) axis is deeply affected by inflammation, its response being characterized by GH resistance and a decrease in circulating levels of IGF-1. The endocrine and metabolic responses to inflammation allow the organism to survive. However, in chronic inflammatory conditions, the inhibition of the hypothalamic–GH–IGF-1 axis contributes to the catabolic process, with skeletal muscle atrophy and cachexia. Here, we review the changes in pituitary GH secretion, IGF-1, and IGF-1 binding protein-3 (IGFBP-3), as well as the mechanism that mediated those responses. The contribution of GH and IGF-1 to muscle wasting during inflammation has also been analyzed.
- Published
- 2021
- Full Text
- View/download PDF
55. Del Mar a las Aulas, un Proyecto Enfocado para Niños y Adolescentes en Alianza con la Armada de Colombia
- Author
-
Leon Gomez, Maria Celeny, Rodriguez Navarro, Juan Camilo, López Calderón, Karen Dayana, Cruz Hernandez, Nancy, and Universidad Santo Tomás
- Subjects
knowledge ,multimedia ,Productos Sonoros ,teenagers ,Conceptos ,concepts ,communication ,Informative ,sonoro ,Informativo ,Maritime ,kids ,Océanos ,sonorous ,Conocimiento ,Multimedia ,Lenguaje ,Comunicación Social ,Comunicación ,oceans ,Marítimo ,Niños ,Adolescentes - Abstract
En el presente documento se recopila y presenta la trayectoria de un producto multimedia enfocado en los cuidados de los mares y de los océanos utilizando un lenguaje adecuado para niños y adolescentes de grados cuarto, quinto, octavo y noveno de colegios locales y departamentales. Esto, con el fin de indagar el nivel de conocimiento de los niños y jóvenes con respecto a la Armada de Colombia e incentivar la protección del mundo marítimo. Con base a la investigación realizada, se plantean diversos productos multimedia en donde se dan a conocer los resultados obtenidos. A su vez, se dejarán diez productos sonoros en donde se complementa el conocimiento acerca de las áreas costeras junto con un blog informativo donde se evidencian los procesos que se llevaron a cabo con los estudiantes de las instituciones educativas. In this document, the trajectory of a multimedia product focused on the care of the seas and oceans will be evidenced, using a language suitable for children and teenagers in fourth, fifth, eighth and ninth grades of local and departmental schools with the purpose of investigate and encourage what they know about the Armada de Colombia, and how the maritime world should be protected. Based on the research that was carried out, various multimedia products were proposed where the results obtained will be announced and in turn ten sound products will be left, where the knowledge about the seaside will be complemented. In addition an informative blog will be found where the processes that were carried out with the students of the educational institutions were evidenced. Comunicador Social Pregrado
- Published
- 2023
56. Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats
- Author
-
Daniel González-Hedström, María de la Fuente-Fernández, Teresa Priego, Ana Isabel Martín, Sara Amor, Asunción López-Calderón, Antonio Manuel Inarejos-García, Ángel Luís García-Villalón, and Miriam Granado
- Subjects
aging ,olive leaf extract ,omega 3 fatty acids ,algae oil ,extra virgin olive oil ,insulin resistance ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Olive-derived products, such as virgin olive oil (EVOO) and/or olive leaf extracts (OLE), exert anti-inflammatory, insulin-sensitizing and antihypertensive properties and may be useful for stabilizing omega 3 fatty acids (n-3 PUFA) due to their high content in antioxidant compounds. In this study, the addition of OLE 4:0.15 (w/w) to a mixture of algae oil (AO) rich in n-3 PUFA and EVOO (25:75, w/w) prevents peroxides formation after 12 months of storage at 30 °C. Furthermore, the treatment with the oil mixture (2.5 mL/Kg) and OLE (100 mg/Kg) to 24 month old Wistar rats for 21 days improved the lipid profile, increased the HOMA-IR and decreased the serum levels of miRNAs 21 and 146a. Treatment with this new nutraceutical also prevented age-induced insulin resistance in the liver, gastrocnemius and visceral adipose tissue by decreasing the mRNA levels of inflammatory and oxidative stress markers. Oil mixture + OLE also attenuated the age-induced alterations in vascular function and prevented muscle loss by decreasing the expression of sarcopenia-related markers. In conclusion, treatment with a new nutraceutical based on a mixture of EVOO, AO and OLE is a useful strategy for improving the stability of n-3 PUFA in the final product and to attenuate the cardiometabolic and muscular disorders associated with aging.
- Published
- 2021
- Full Text
- View/download PDF
57. Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle
- Author
-
Daniel González-Hedström, Teresa Priego, Sara Amor, María de la Fuente-Fernández, Ana Isabel Martín, Asunción López-Calderón, Antonio Manuel Inarejos-García, Ángel Luís García-Villalón, and Miriam Granado
- Subjects
aging ,adipose tissue ,skeletal muscle ,sarcopenia ,insulin resistance ,olive leaf extract ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Aging is associated with increased visceral adiposity and a decrease in the amount of brown adipose tissue and muscle mass, known as sarcopenia, which results in the development of metabolic alterations such as insulin resistance. In this study, we aimed to analyze whether 3-week supplementation with a phenolic-rich olive leaf extract (OLE) to 24 months-old male Wistar rats orally (100 mg/kg) attenuated the aging-induced alterations in body composition and insulin resistance. OLE treatment increased brown adipose tissue and attenuated the aging-induced decrease in protein content and gastrocnemius weight. Treatment with OLE prevented the aging-induced increase in the expression of PPAR-γ in visceral and brown adipose tissues, while it significantly increased the expression of PPAR-α in the gastrocnemius of old rats and reduced various markers related to sarcopenia such as myostatin, HDAC-4, myogenin and MyoD. OLE supplementation increased insulin sensitivity in explants of gastrocnemius and epididymal visceral adipose tissue from aged rats through a greater activation of the PI3K/Akt pathway, probably through the attenuation of inflammation in both tissues. In conclusion, supplementation with OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle.
- Published
- 2021
- Full Text
- View/download PDF
58. Evaluation of the taxonomic composition of phytoplankton using microscopy and CHEMTAX in Todos Santos Bay (Baja California, México) during 2017-2018
- Author
-
Ramírez-Altamirano, Yessica Lizbeth, primary, González-Silvera, Adriana, additional, López-Calderón, Jorge, additional, and Santamaria-del-Angel, Eduardo, additional
- Published
- 2023
- Full Text
- View/download PDF
59. Supplementary Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer
- Author
-
Martínez, Víctor G., primary, Rubio, Carolina, primary, Martínez-Fernández, Mónica, primary, Segovia, Cristina, primary, López-Calderón, Fernando, primary, Garín, Marina I., primary, Teijeira, Alicia, primary, Munera-Maravilla, Ester, primary, Varas, Alberto, primary, Sacedón, Rosa, primary, Guerrero, Félix, primary, Villacampa, Felipe, primary, de la Rosa, Federico, primary, Castellano, Daniel, primary, López-Collazo, Eduardo, primary, Paramio, Jesús M., primary, Vicente, Ángeles, primary, and Dueñas, Marta, primary
- Published
- 2023
- Full Text
- View/download PDF
60. Supplementary Table 4 from CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status
- Author
-
Rubio, Carolina, primary, Martínez-Fernández, Mónica, primary, Segovia, Cristina, primary, Lodewijk, Iris, primary, Suarez-Cabrera, Cristian, primary, Segrelles, Carmen, primary, López-Calderón, Fernando, primary, Munera-Maravilla, Ester, primary, Santos, Mirentxu, primary, Bernardini, Alejandra, primary, García-Escudero, Ramón, primary, Lorz, Corina, primary, Gómez-Rodriguez, Maria José, primary, de Velasco, Guillermo, primary, Otero, Irene, primary, Villacampa, Felipe, primary, Guerrero-Ramos, Felix, primary, Ruiz, Sergio, primary, de la Rosa, Federico, primary, Domínguez-Rodríguez, Sara, primary, Real, Francisco X., primary, Malats, Núria, primary, Castellano, Daniel, primary, Dueñas, Marta, primary, and Paramio, Jesus M., primary
- Published
- 2023
- Full Text
- View/download PDF
61. Supplementary Data from CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status
- Author
-
Rubio, Carolina, primary, Martínez-Fernández, Mónica, primary, Segovia, Cristina, primary, Lodewijk, Iris, primary, Suarez-Cabrera, Cristian, primary, Segrelles, Carmen, primary, López-Calderón, Fernando, primary, Munera-Maravilla, Ester, primary, Santos, Mirentxu, primary, Bernardini, Alejandra, primary, García-Escudero, Ramón, primary, Lorz, Corina, primary, Gómez-Rodriguez, Maria José, primary, de Velasco, Guillermo, primary, Otero, Irene, primary, Villacampa, Felipe, primary, Guerrero-Ramos, Felix, primary, Ruiz, Sergio, primary, de la Rosa, Federico, primary, Domínguez-Rodríguez, Sara, primary, Real, Francisco X., primary, Malats, Núria, primary, Castellano, Daniel, primary, Dueñas, Marta, primary, and Paramio, Jesus M., primary
- Published
- 2023
- Full Text
- View/download PDF
62. Nitrógeno total en maíz forrajero (Zea mays L.) estimado mediante índices espectrales con el satélite Sentinel-2
- Author
-
López-Calderón, Magali J., primary, Estrada-Ávalos, Juan, additional, Martínez-Sifuentes, Aldo R., additional, Trucíos-Caciano, Ramón, additional, and Miguel-Valle, Enrique, additional
- Published
- 2023
- Full Text
- View/download PDF
63. Time-Dependent Changes in Muscle IGF1-IGFBP5-PAPP System after Sciatic Denervation
- Author
-
Martín Velasco, Ana Isabel, Moreno Rupérez, Álvaro, Nebot Valenzuela, Elena, Granado, Miriam, Jaque, Daniel, Nieto Bona, María Paz, López-Calderón Barreda, Asunción, Priego Cuadra, Teresa, Martín Velasco, Ana Isabel, Moreno Rupérez, Álvaro, Nebot Valenzuela, Elena, Granado, Miriam, Jaque, Daniel, Nieto Bona, María Paz, López-Calderón Barreda, Asunción, and Priego Cuadra, Teresa
- Abstract
Denervation-induced muscle atrophy is a frequent cause of skeletal muscle diseases. However, the role of the most important muscle growth factor, insulin-like growth factor (IGF-1), in this process is poorly understood. IGF-1 activity is controlled by six IGF-1 binding proteins (IGFBPs). In skeletal muscle, IGFBP-5 seems to have an important role in atrophic processes. Furthermore, pappalysins (PAPP-A) modulate muscle growth by increasing IGF-1 bioavailability through IGFBP cleavage. We aimed to study the time-dependent changes in the IGF1-IGFBP5-PAPP system and its regulators in gastrocnemius muscle after sciatic denervation. Gastrocnemius atrophy and overexpression of IGF-1 was observed from day 3 post-denervation. The proteolytic factors measured were elevated from day 1 post-denervation onwards. Expression of both IGFBP-5 and pappalysins were increased on days 1 and 3. Subsequently, on days 7 to 14 pappalysins returned to control levels while IGFBP-5 remained elevated. The ratio IGFBP-5/PAPP-A was correlated with the main proteolytic markers. All data suggest that the initial increase of pappalysins could facilitate the IGF-1 action on muscle growth, whereas their subsequent decrease could lead to further muscle wasting., Unión Europea, Ministerio de Economía y Competitividad-MINECO, Comunidad de Madrid, Depto. de Fisiología, Fac. de Medicina, TRUE, pub
- Published
- 2023
64. La Virgen y los (mal) llamados símbolos de la letanía lauretana
- Author
-
Universidade de Santiago de Compostela. Departamento de Historia da Arte, López Calderón, Carme, Universidade de Santiago de Compostela. Departamento de Historia da Arte, and López Calderón, Carme
- Abstract
Los símbolos que la tradición ha aplicado a la Virgen María tienden a identificarse, en los estudios de cultura visual, como los “símbolos de las letanías marianas” o “símbolos de la letanía lauretana”. El presente artículo rastrea su origen en la patrística y su presencia en la Edad Media y Moderna, demostrando que su uso trasciende ampliamente las composiciones litánicas y ofreciendo una posible explicación para esta (mal)interpretación generalizada. Igualmente, propone sistematizar en cuatro grandes fórmulas la tipología general de Virgen acompañada de símbolos, al tiempo que evidencia cómo el significado de estos viene condicionado por la representación mariana que completan. Finalmente, aborda la presencia aislada de los mismos, planteando tanto qué pudo favorecer su autonomía, como la necesidad de cuestionarse dicha independencia. The symbols that have been traditionally applied to the Virgin Mary tend to be referred to in visual studies as the “symbols of the Marian litanies” or “symbols of the Laurentian/Lauretanian Litany”. This article traces their origin in Patristics and their presence in the Middle Ages and Modern Age, demonstrating that their use widely transcends litany compositions and offers a possible explanation for this widespread (mis)interpretation. At the same time, it aims to establish a systematic categorization of the general typology of the Virgin accompanied by symbols within four broad frameworks. Additionally, it seeks to provide evidence of how the meaning of these symbols is conditioned by the Marian representation they complete. Finally, it addresses their isolated presence, raising questions about what might have contributed to their autonomy and emphasizing the importance of scrutinizing this independence., The symbols that have been traditionally applied to the Virgin Mary tend to be referred to in visual studies as the “symbols of the Marian litanies” or “symbols of the Laurentian/Lauretanian Litany”. This article traces their origin in Patristics and their presence in the Middle Ages and Modern Age, demonstrating that their use widely transcends litany compositions and offers a possible explanation for this widespread (mis)interpretation. At the same time, it aims to establish a systematic categorization of the general typology of the Virgin accompanied by symbols within four broad frameworks. Additionally, it seeks to provide evidence of how the meaning of these symbols is conditioned by the Marian representation they complete. Finally, it addresses their isolated presence, raising questions about what might have contributed to their autonomy and emphasizing the importance of scrutinizing this independence
- Published
- 2023
65. La aplicación del Concilio de Trento en el Arte Gallego
- Author
-
López Calderón, Carme, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Historia, Xeografía e Historia da Arte, Cotelo Felípez, Mario, López Calderón, Carme, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Historia, Xeografía e Historia da Arte, and Cotelo Felípez, Mario
- Abstract
Después de concluído el Concilio de Trento, los documentos emanados de él repercuten en la vida de la iglesia gallega. Para demostrarlo, en esta tesis doctoral se toma como ejemplo la Arquidiócesis de Santiago de Compostela en tanto que sede metropolitana y, teniendo como hilo conductor el pecado (cuya consecuencia última es la muerte y, por consiguiente, la salvación), se establecen cuatro áreas de investigación. La primera se centra en los decretos de la gracia y de la justificación, demostrando su influencia en la obra de arte como biblia pauperum y, en concreto, analizando tres ámbitos principales de aplicación de los textos conciliares: la escultura marginal, las fundaciones y los retablos, especialmente los de ánimas. La segunda área gira en torno de la figura de María, la sin pecado, evidenciando cómo con el desarrollo de los dogmas y creencias piadosas aparecen nuevas advocaciones que dan lugar a una evolución de la imagen a través de los textos. En la tercera, dedicada a la sacramentalidad, se exponen los motivos para luchar contra el pecado, haciendo hincapié en la Eucaristía y cómo en ella existe un trasfondo de evitarlo. En este sentido, con el estudio de los retablos, de los sagrarios y de la imagen de la Fe se trasluce la preocupación de la herejía. Finalmente, la última área aborda aquellos que luchan con el pecado: los santos. A través de estos cuatro bloques temáticos es posible constatar cómo en la obra de arte se producen tanto nuevas implantaciones como la recuperación de tipologías tradicionales olvidadas, modernizándose a medida que avanzan los siglos del Concilio. La imagen, determinada por los textos conciliares e independientemente del formato artístico que adopta, la literatura y la mentalidad de cada época configuran un universo en constante expansión a medida que Trento se implanta paulatinamente, dando lugar a una expresión en el ámbito artístico, y contrariamente a lo que se tiende a pensar, que claramente evoluciona a medida que avanza
- Published
- 2023
66. White stork movements reveal the ecological connectivity between landfills and different habitats
- Author
-
Consejo Superior de Investigaciones Científicas (España), Conferencia de Rectores de las Universidades Españolas, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía, German Research Foundation, European Commission, Max Planck Society, Minerva Foundation, López-Calderón, Cosme, Martín-Vélez, Víctor, Blas, Julio, Höfle, Ursula, Sánchez, Marta I., Flack, Andrea, Fiedler, Wolfgang, Wikelski, Martin, Green, Andy J., Consejo Superior de Investigaciones Científicas (España), Conferencia de Rectores de las Universidades Españolas, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía, German Research Foundation, European Commission, Max Planck Society, Minerva Foundation, López-Calderón, Cosme, Martín-Vélez, Víctor, Blas, Julio, Höfle, Ursula, Sánchez, Marta I., Flack, Andrea, Fiedler, Wolfgang, Wikelski, Martin, and Green, Andy J.
- Abstract
[Background] Connections between habitats are key to a full understanding of anthropic impacts on ecosystems. Freshwater habitats are especially biodiverse, yet depend on exchange with terrestrial habitats. White storks (Ciconia ciconia) are widespread opportunists that often forage in landfills and then visit wetlands, among other habitats. It is well known that white storks ingest contaminants at landfills (such as plastics and antibiotic resistant bacteria), which can be then deposited in other habitats through their faeces and regurgitated pellets., [Methods] We characterized the role of white storks in habitat connectivity by analyzing GPS data from populations breeding in Germany and wintering from Spain to Morocco. We overlaid GPS tracks on a land-use surface to construct a spatially-explicit network in which nodes were sites, and links were direct flights. We then calculated centrality metrics, identified spatial modules, and quantified overall connections between habitat types. For regional networks in southern Spain and northern Morocco, we built Exponential Random Graph Models (ERGMs) to explain network topologies as a response to node habitat., [Results] For Spain and Morocco combined, we built a directed spatial network with 114 nodes and 370 valued links. Landfills were the habitat type most connected to others, as measured by direct flights. The relevance of landfills was confirmed in both ERGMs, with significant positive effects of this habitat as a source of flights. In the ERGM for southern Spain, we found significant positive effects of rice fields and salines (solar saltworks) as sinks for flights. By contrast, in the ERGM for northern Morocco, we found a significant positive effect of marshes as a sink for flights., [Conclusions] These results illustrate how white storks connect landfills with terrestrial and aquatic habitats, some of which are managed for food production. We identified specific interconnected habitat patches across Spain and Morocco that could be used for further studies on biovectoring of pollutants, pathogens and other propagules.
- Published
- 2023
67. Arcanxos : combatentes, mensaxeiros e custodios. Tipos iconográficos en Europa e a súa tradición en América Latina
- Author
-
López Calderón, Carme, Universidade de Santiago de Compostela. Departamento de Historia da Arte, Huertas Gómez, Cristina, López Calderón, Carme, Universidade de Santiago de Compostela. Departamento de Historia da Arte, and Huertas Gómez, Cristina
- Abstract
A través dun percorrido que abarca dende o Renacemento ao Barroco búscase establecer os diferentes tipos iconográficos das representacións dos arcanxos canónicos: San Miguel, San Gabriel e San Rafael, procurando tamén as súas orixes no mundo antigo. Para isto préstase atención aos episodios que protagoniza cada arcanxo e que contribúen a xerar a súa tipoloxía conceptual. Na mesma liña, tamén se atende a tradición que continúan esas mesmas imaxes nas rexións hispanas de América. Por outra parte, repárase na tipoloxía iconográfica dos Sete Príncipes Celestes, orixinaria de Europa pero con unha importante difusión nos virreinatos americanos. Deste xeito, póñense en valor os retratos grupais nos que aparecen tanto os arcanxos canónicos como os apócrifos., A través de un recorrido que abarca desde el Renacimiento al Barroco se busca establecer los diferentes tipos iconográficos de las representaciones de los arcángeles canónicos: San Miguel, San Gabriel y San Rafael, buscando también sus orígenes en el mundo antiguo. Para esto se presta atención a los episodios que protagoniza cada arcángel y que contribuye a generar su tipología conceptual. En la misma línea, también se atiende a la tradición que continúan esas mismas imágenes en las regiones hispanas de América. Por otra parte, se presta atención a la tipología iconográfica de los Siete Príncipes Celestes, originaria de Europa, pero con una importante difusión en los virreinatos americanos. De este modo, se ponen en valor los retratos grupales en los que aparecen tanto los arcángeles canónicos como los apócrifos., Through a journey from the Renaissance to the Baroque, the aim is to establish the different iconographic types of the representations of the canonical archangels: Saitn Michael, Saint Gabriel and Saint Raphael, also looking for their origins in the ancient world. For this, attention is paid to the episodes that each archangel stars in and that contributes to generating its conceptual typology. Along the same lines, attention is paid to the tradition that these same images continue in the Hispanic regions of America. On the other hand, attention is paid to the iconographic typology of the Seven Heavenly Princes, originally from Europe, but with an important diffusion in the American viceroyalties. In this way, special attention is put on the episodes where the different archangels play a major role.
- Published
- 2023
68. Biovectoring of plastic by white storks from a landfill to a complex of salt ponds and marshes
- Author
-
Universidad de Sevilla. Departamento de Zoología, Junta de Andalucía, Universidad de Cádiz, Cano Povedano, Julián, López Calderón, Cosme, Sánchez Ordóñez, Marta Isabel, Hortas, Francisco, Cañuelo Jurado, Belén, Martín Vélez, Víctor, Ros Clemente, Macarena, Cózar, Andrés, Green, Andy J., Universidad de Sevilla. Departamento de Zoología, Junta de Andalucía, Universidad de Cádiz, Cano Povedano, Julián, López Calderón, Cosme, Sánchez Ordóñez, Marta Isabel, Hortas, Francisco, Cañuelo Jurado, Belén, Martín Vélez, Víctor, Ros Clemente, Macarena, Cózar, Andrés, and Green, Andy J.
- Abstract
Research into plastic pollution has extensively focused on abiotic vectors, overlooking transport by animals. Opportunistic birds, such as white storks (Ciconia ciconia) often forage on landfills, where plastic abounds. We assess plastic loading by ingestion and regurgitation of landfill plastic in Cadiz Bay, a major stopover area for migratory white storks in south-west Spain. On average, we counted 599 storks per day moving between a landfill and a complex of salt ponds and marshes, where they regurgitated pellets that each contained a mean of 0.47 g of plastic debris, dominated by polyethylene. Modelling reliant on GPS tracking estimated that 99 kg and >2 million particles of plastic were biovectored into the wetland during 2022, with seasonal peaks that followed migration patterns. GPS data enabled the correction of field censuses and the identification of plastic deposition hotspots. This study highlights the important role that biovectoring plays in plastic transport into coastal wetlands.
- Published
- 2023
69. Interannual Climate Variability in the West Antarctic Peninsula under Austral Summer Conditions.
- Author
-
Eduardo Santamaría-del-ángel, Mary-Luz Cañon-Páez, María-Teresa Sebastiá-Frasquet, Adriana González-Silvera, Angelica-L. Gutierrez, Jesús Antonio Aguilar-Maldonado, Jorge López-Calderón, Víctor Camacho-Ibar, Andrés Franco-Herrera, and Alejandra Castillo-Ramírez
- Published
- 2021
- Full Text
- View/download PDF
70. Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer
- Author
-
Marta Dueñas, Ángeles Vicente, Jesús M. Paramio, Eduardo López-Collazo, Daniel Castellano, Federico de la Rosa, Felipe Villacampa, Félix Guerrero, Rosa Sacedón, Alberto Varas, Ester Munera-Maravilla, Alicia Teijeira, Marina I. Garín, Fernando López-Calderón, Cristina Segovia, Mónica Martínez-Fernández, Carolina Rubio, and Víctor G. Martínez
- Abstract
Purpose: Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence rate, which could progress to muscle-invasive disease and metastasis. Bone morphogenetic protein (BMP)–dependent signaling arising from stromal bladder tissue mediates urothelial homeostasis by promoting urothelial cell differentiation. However, the possible role of BMP ligands in bladder cancer is still unclear.Experimental Design: Tumor and normal tissue from 68 patients with urothelial cancer were prospectively collected and analyzed for expression of BMP and macrophage markers. The mechanism of action was assessed in vitro by experiments with bladder cancer cell lines and peripheral blood monocyte–derived macrophages.Results: We observed BMP4 expression is associated and favored type II macrophage differentiation. In vitro experiments showed that both recombinant BMP4 and BMP4-containing conditioned media from bladder cancer cell lines favored monocyte/macrophage polarization toward M2 phenotype macrophages, as shown by the expression and secretion of IL10. Using a series of human bladder cancer patient samples, we also observed increased expression of BMP4 in advanced and undifferentiated tumors in close correlation with epithelial–mesenchymal transition (EMT). However, the p-Smad 1,5,8 staining in tumors showing EMT signs was reduced, due to the increased miR-21 expression leading to reduced BMPR2 expression.Conclusions: These findings suggest that BMP4 secretion by bladder cancer cells provides the M2 signal necessary for a protumoral immune environment. In addition, the repression of BMPR2 by miR-21 makes the tumor cells refractory to the prodifferentiating actions mediated by BMP ligands, favoring tumor growth. Clin Cancer Res; 23(23); 7388–99. ©2017 AACR.
- Published
- 2023
71. Data from CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status
- Author
-
Jesus M. Paramio, Marta Dueñas, Daniel Castellano, Núria Malats, Francisco X. Real, Sara Domínguez-Rodríguez, Federico de la Rosa, Sergio Ruiz, Felix Guerrero-Ramos, Felipe Villacampa, Irene Otero, Guillermo de Velasco, Maria José Gómez-Rodriguez, Corina Lorz, Ramón García-Escudero, Alejandra Bernardini, Mirentxu Santos, Ester Munera-Maravilla, Fernando López-Calderón, Carmen Segrelles, Cristian Suarez-Cabrera, Iris Lodewijk, Cristina Segovia, Mónica Martínez-Fernández, and Carolina Rubio
- Abstract
Purpose:Bladder cancer is a clinical and social problem due to its high incidence and recurrence rates. It frequently appears in elderly patients showing other medical comorbidities that hamper the use of standard chemotherapy. We evaluated the activity of CDK4/6 inhibitor as a new therapy for patients unfit for cisplatin (CDDP).Experimental Design:Bladder cancer cell lines were tested for in vitro sensitivity to CDK4/6 inhibition. A novel metastatic bladder cancer mouse model was developed and used to test its in vivo activity.Results:Cell lines tested were sensitive to CDK4/6 inhibition, independent on RB1 gene status. Transcriptome analyses and knockdown experiments revealed a major role for FOXM1 in this response. CDK4/6 inhibition resulted in reduced FOXM1 phosphorylation in vitro and in vivo and showed synergy with CDDP, allowing a significant tumor regression. FOXM1 exerted important oncogenic roles in bladder cancer.Conclusions:CDK4/6 inhibitors, alone or in combination, are a novel therapeutic strategy for patients with advanced bladder cancer previously classified as unfit for current treatment options.
- Published
- 2023
72. Supplementary Table 4 from CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status
- Author
-
Jesus M. Paramio, Marta Dueñas, Daniel Castellano, Núria Malats, Francisco X. Real, Sara Domínguez-Rodríguez, Federico de la Rosa, Sergio Ruiz, Felix Guerrero-Ramos, Felipe Villacampa, Irene Otero, Guillermo de Velasco, Maria José Gómez-Rodriguez, Corina Lorz, Ramón García-Escudero, Alejandra Bernardini, Mirentxu Santos, Ester Munera-Maravilla, Fernando López-Calderón, Carmen Segrelles, Cristian Suarez-Cabrera, Iris Lodewijk, Cristina Segovia, Mónica Martínez-Fernández, and Carolina Rubio
- Abstract
Supplementary Table 4: Spreadsheet of transcriptomic data
- Published
- 2023
73. Supplementary Data from CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status
- Author
-
Jesus M. Paramio, Marta Dueñas, Daniel Castellano, Núria Malats, Francisco X. Real, Sara Domínguez-Rodríguez, Federico de la Rosa, Sergio Ruiz, Felix Guerrero-Ramos, Felipe Villacampa, Irene Otero, Guillermo de Velasco, Maria José Gómez-Rodriguez, Corina Lorz, Ramón García-Escudero, Alejandra Bernardini, Mirentxu Santos, Ester Munera-Maravilla, Fernando López-Calderón, Carmen Segrelles, Cristian Suarez-Cabrera, Iris Lodewijk, Cristina Segovia, Mónica Martínez-Fernández, and Carolina Rubio
- Abstract
Includes Supplementary Figures 1-13; Supplementary Tables 1, 2, 3, 7 and 8; and Supplementary References
- Published
- 2023
74. Supplementary Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer
- Author
-
Marta Dueñas, Ángeles Vicente, Jesús M. Paramio, Eduardo López-Collazo, Daniel Castellano, Federico de la Rosa, Felipe Villacampa, Félix Guerrero, Rosa Sacedón, Alberto Varas, Ester Munera-Maravilla, Alicia Teijeira, Marina I. Garín, Fernando López-Calderón, Cristina Segovia, Mónica Martínez-Fernández, Carolina Rubio, and Víctor G. Martínez
- Abstract
Supplementary Table 1. Bladder Cancer cell lines. Supplementary Table 2. Primers and TaqMan probes used for qPCR. Supplementary Figure 1.Characterization of monocyte/macrophage polarization. Supplementary Figure 2. Resistance of BCCs to monocyte-induced apoptosis Supplementary Figure 3. Macrophage marker evaluation toward tumorigenesis and recurrence Supplementary Figure 4. Analyses of different factors that may influence time to recurrence Supplementary Figure 5.CD 163 expression in Tissue microarrays. Representative positive (A) and negative (B) tumors are shown. Supplementary Figure 6.BMP4 expression on NMIBC and MIBC
- Published
- 2023
75. Supplementary Table 5 from CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status
- Author
-
Jesus M. Paramio, Marta Dueñas, Daniel Castellano, Núria Malats, Francisco X. Real, Sara Domínguez-Rodríguez, Federico de la Rosa, Sergio Ruiz, Felix Guerrero-Ramos, Felipe Villacampa, Irene Otero, Guillermo de Velasco, Maria José Gómez-Rodriguez, Corina Lorz, Ramón García-Escudero, Alejandra Bernardini, Mirentxu Santos, Ester Munera-Maravilla, Fernando López-Calderón, Carmen Segrelles, Cristian Suarez-Cabrera, Iris Lodewijk, Cristina Segovia, Mónica Martínez-Fernández, and Carolina Rubio
- Abstract
Supplementary Table 5: Spreadsheet of transcriptomic data
- Published
- 2023
76. Beneficial Effects of a Mixture of Algae and Extra Virgin Olive Oils on the Age-Induced Alterations of Rodent Skeletal Muscle: Role of HDAC-4
- Author
-
Daniel González-Hedström, Teresa Priego, Asunción López-Calderón, Sara Amor, María de la Fuente-Fernández, Antonio Manuel Inarejos-García, Ángel Luis García-Villalón, Ana Isabel Martín, and Miriam Granado
- Subjects
aging ,omega 3 fatty acids ,extra virgin olive oil ,sarcopenia ,atrogenes ,autophagy ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Aging is associated with a progressive decline in skeletal muscle mass, strength and function (sarcopenia). We have investigated whether a mixture of algae oil (25%) and extra virgin olive oil (75%) could exert beneficial effects on sarcopenia. Young (3 months) and old (24 months) male Wistar rats were treated with vehicle or with the oil mixture (OM) (2.5 mL/kg) for 21 days. Aging decreased gastrocnemius weight, total protein, and myosin heavy chain mRNA. Treatment with the OM prevented these effects. Concomitantly, OM administration decreased the inflammatory state in muscle; it prevented the increase of pro-inflammatory interleukin-6 (IL-6) and the decrease in anti-inflammatory interleukin-10 (IL-10) in aged rats. The OM was not able to prevent aging-induced alterations in either the insulin-like growth factor I/protein kinase B (IGF-I/Akt) pathway or in the increased expression of atrogenes in the gastrocnemius. However, the OM prevented decreased autophagy activity (ratio protein 1A/1B-light chain 3 (LC3b) II/I) induced by aging and increased expression of factors related with muscle senescence such as histone deacetylase 4 (HDAC-4), myogenin, and IGF-I binding protein 5 (IGFBP-5). These data suggest that the beneficial effects of the OM on muscle can be secondary to its anti-inflammatory effect and to the normalization of HDAC-4 and myogenin levels, making this treatment an alternative therapeutic tool for sarcopenia.
- Published
- 2020
- Full Text
- View/download PDF
77. Starling Movements: Connectivity at the Human-Wildlife Interface with Implications for Pathogen Dispersal
- Author
-
Sanchez-Cano Moreno de Redrojo, Alberto, primary, López-Calderón, Cosme, additional, Cardona Cabrera, Teresa, additional, Green, Andy J., additional, and Höfle, Ursula, additional
- Published
- 2023
- Full Text
- View/download PDF
78. Llegir, comprendre, aprendre. Pràctica de comprensió lectora PISA per a lectors de 10 a 13 anys
- Author
-
Conejos Vicente, Ana, primary, López Calderón, Mª José, additional, and Mesejo Conejos, Maria, additional
- Published
- 2017
- Full Text
- View/download PDF
79. LEER, COMPRENDER, APRENDER. Práctica de comprensión lectora PISA para lectores de 10 a 13 años
- Author
-
Conejos Vicente, Ana, primary, López Calderón, Mª José, additional, and Mesejo Conejos, Maria, additional
- Published
- 2017
- Full Text
- View/download PDF
80. Validating the Spanish Adverse Childhood Experiences International Questionnaire (ACE-IQ): A Mexican Analysis
- Author
-
Téllez, Arnoldo, primary, Almaraz-Castruita, Diana Aracely, additional, Valdez, Arturo, additional, Juárez-García, Dehisy Marisol, additional, de Jesús Sánchez-Jáuregui, Teresa, additional, Hinojosa Fernández, Rogelio, additional, López Calderón, Shayam Fernanda, additional, and García Balvaneda, Hugo, additional
- Published
- 2022
- Full Text
- View/download PDF
81. EZH2 in Bladder Cancer, a Promising Therapeutic Target
- Author
-
Mónica Martínez-Fernández, Carolina Rubio, Cristina Segovia, Fernando F. López-Calderón, Marta Dueñas, and Jesús M. Paramio
- Subjects
bladder cancer ,Polycomb ,EZH2 ,miRNA ,lncRNA ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Bladder Cancer (BC) represents a current clinical and social challenge. The recent studies aimed to describe the genomic landscape of BC have underscored the relevance of epigenetic alterations in the pathogenesis of these tumors. Among the epigenetic alterations, histone modifications occupied a central role not only in cancer, but also in normal organism homeostasis and development. EZH2 (Enhancer of Zeste Homolog 2) belongs to the Polycomb repressive complex 2 as its catalytic subunit, which through the trimethylation of H3 (Histone 3) on K27 (Lysine 27), produces gene silencing. EZH2 is frequently overexpressed in multiple tumor types, including BC, and plays multiple roles besides the well-recognized histone mark generation. In this review, we summarize the present knowledge on the oncogenic roles of EZH2 and its potential use as a therapeutic target, with special emphasis on BC pathogenesis and management.
- Published
- 2015
- Full Text
- View/download PDF
82. A SERVICE-LEARNING PROJECT AS A TEACHING TOOL TO FIGHT AGAINST HYPERTENSION
- Author
-
Ana Alejandra Sánchez-Pina, Ángel Agis-Torres, Sara Benedito, Cristina Contreras, Alfonso Gómez Del Val, Marina Hernández-Martín, Medardo Vicente Hernández, J Isaa, Vítor Samuel Leite Fernandes, Maria Pilar Montenegro, Mercedes Muñoz-Picos, Jorge Navarro-Dorado, Natalia Fernanda Pascual, Dolores Prieto, Rafaela Raposo, Paz Recio, Rocío Redondo-Castillejo, Luis Rivera, Jose Manuel Bravo, Victoria Cachofeiro, José Antonio García Baró, María Dulce Gómez Garre, Ricardo Gredilla, Natalia de las Heras, Verónica Hurtado-Carneiro, Asunción López-Calderón, Ana Isabel Martín Velasco, Ernesto Martínez-Martínez, Álvaro Moreno-Rupérez, Elena Nebot, Sergio Damián Paredes, Teresa Priego, Raquel Rodrígues-Díez, Alberto Sánchez-Aguilera, María Sancho, Gregorio Segovia, Francisco Das Chagas Vasconcelos, Ángeles Vicente-Torres, and María Elvira López-Oliva
- Published
- 2022
83. Estimation of Total Nitrogen Content in Forage Maize (Zea mays L.) Using Spectral Indices: Analysis by Random Forest
- Author
-
Magali J. López-Calderón, Juan Estrada-Ávalos, Víctor M. Rodríguez-Moreno, Jorge E. Mauricio-Ruvalcaba, Aldo R. Martínez-Sifuentes, Gerardo Delgado-Ramírez, and Enrique Miguel-Valle
- Subjects
nitrogen content ,remote sensing ,spectral indices ,random forest ,Agriculture (General) ,S1-972 - Abstract
Knowing the total Nitrogen content (Nt) of forage maize (Zea mays) is important so that decisions can be made quickly and efficiently to adjust the timing and amount of both irrigation and fertilizer. In 2017 and 2018 during three growing cycles in two study plots, leaf samples were collected and the Dumas method was used to estimate Nt. During the same growing seasons and on the same sampling plots, a Parrot Sequoia camera mounted on an unmanned aerial vehicle (UAV) was used to collect high resolution images of forage maize study plots. Thirteen multispectral indices were generated and, from these, a Random Forest (RF) algorithm was used to estimate Nt. RF is a machine-learning technique and is designed to work with extremely large datasets. Overall analysis showed five of the 13 indices as the most important. One of these five, the Transformed Chlorophyll Absorption in Reflectance Index/Optimized Soil-Adjusted Vegetation Index, was found to be the most important for estimation of Nt in forage maize (R2 = 0.76). RF handled the complex dataset in a time-efficient manner and Nt did not differ significantly when compared between traditional methods of evaluating Nt at the canopy level and using UAVs and RF to estimate Nt in forage maize. This result is an opportunity to explore many new research options in precision farming and digital agriculture.
- Published
- 2020
- Full Text
- View/download PDF
84. Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing
- Author
-
Héctor D. López-Calderón, Hamlet Avilés-Arnaut, Luis J. Galán-Wong, Verónica Almaguer-Cantú, J. R. Laguna-Camacho, C. Calderón-Ramón, J. E. Escalante-Martínez, and Katiushka Arévalo-Niño
- Subjects
electrospinning ,biomaterial ,nanofibers ,wound dressing ,antibacterial ,Organic chemistry ,QD241-441 - Abstract
Acceleration of wound healing can be achieved with the use of wound dressings. Through the electrospinning technique, a polymeric scaffold composed of two layers was processed: a gelatin and polyvinylpyrrolidone layer with gentamicin, and a second layer of cellulose acetate. The conditions for the electrospinning process were standardized for voltage parameters, feed flow and the distance from the injector to the collector. Once the values of the main variables for the electrospinning were optimized, a three-hour processing time was established to allow the separation of the material from the collector. The obtained material was characterized by observations on scanning electron microscopy, Fourier transform infrared spectroscopy and thermal analysis; contact angle measurement was performed to evaluate wettability properties, and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus were evaluated using the Kirby–Bauer test. The obtained fibers that form the bi-layer scaffold present diameters from 100 to 300 nm. The scaffold presents chemical composition, thermal stability, wettability characteristics and antibacterial activity that fulfill the proposal from this study, based on obtaining a scaffold that could be used as a drug delivery vehicle and a wound dressing material.
- Published
- 2020
- Full Text
- View/download PDF
85. The Effect of Cold and Warm Anomalies on Phytoplankton Pigment Composition in Waters off the Northern Baja California Peninsula (México): 2007–2016
- Author
-
Adriana González-Silvera, Eduardo Santamaría-del-Ángel, Víctor Camacho-Ibar, Jorge López-Calderón, Jonatan Santander-Cruz, and Alfredo Mercado-Santana
- Subjects
phytoplankton community composition ,phytoplankton pigments ,Chemtax ,MODIS ,Pacific Warm Anomaly ,El Niño ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 ,Oceanography ,GC1-1581 - Abstract
In this study, we report the response of phytoplankton community composition to cold and warm interannual events affecting the waters off the Baja California Peninsula from 2007 to 2016 based on data obtained from a single marine station (31.75° N/116.96° W). Included variables were satellite chlorophyll a, sea surface temperature (MODIS/Aqua), upwelling intensity, and field data (phytoplankton pigments, inorganic nutrients, light penetration). Phytoplankton pigments were determined by high performance liquid chromatography, and CHEMTAX software was used to determine the relative contributions of the main taxonomic groups to chlorophyll a. Our results confirm the decrease in phytoplankton biomass due to the influence of the recent Pacific Warm Anomaly (2014) and El Niño 2015–2016. However, this decrease was especially marked at the surface. When data from the entire water column was considered, this decrease was not significant, because at the subsurface Chla did not decrease as much. Nevertheless, significant changes in community composition occurred in the entire water column with Cyanobacteria (including Prochlorococcus) and Prymnesiophytes being dominant at the surface, while Chlorophytes and Prasinophytes made a strong contribution at the subsurface. Analysis of the spatial distribution of SST and satellite chlorophyll a made it possible to infer the spatial extension of these anomalies at a regional scale.
- Published
- 2020
- Full Text
- View/download PDF
86. A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats
- Author
-
Daniel González-Hedström, Sara Amor, María de la Fuente-Fernández, Antonio Tejera-Muñoz, Teresa Priego, Ana Isabel Martín, Asunción López-Calderón, Antonio Manuel Inarejos-García, Ángel Luís García-Villalón, and Miriam Granado
- Subjects
aging ,omega 3 fatty acids ,extra virgin olive oil ,insulin resistance ,cardiovascular ,inflammation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Aging is one of the major risk factors for suffering cardiovascular and metabolic diseases. Due to the increase in life expectancy, there is a strong interest in the search for anti-aging strategies to treat and prevent these aging-induced disorders. Both omega 3 polyunsaturated fatty acids (ω-3 PUFA) and extra virgin olive oil (EVOO) exert numerous metabolic and cardiovascular benefits in the elderly. In addition, EVOO constitutes an interesting ingredient to stabilize ω-3 PUFA and decrease their oxidation process due to its high content in antioxidant compounds. ω-3 PUFA are commonly obtained from fish. However, more ecological and sustainable sources, such as algae oil (AO) can also be used. In this study, we aimed to study the possible beneficial effect of an oil mixture composed by EVOO (75%) and AO (25%) rich in ω-3 PUFA (35% docosahexaenoic acid (DHA) and 20% eicosapentaenoic acid (EPA)) on the cardiometabolic alterations associated with aging. For this purpose; young (three months old) and old (24 months old) male Wistar rats were treated with vehicle or with the oil mixture (2.5 mL/kg) for 21 days. Treatment with the oil mixture prevented the aging-induced increase in the serum levels of saturated fatty acids (SFA) and the aging-induced decrease in the serum concentrations of mono-unsaturated fatty acids (MUFA). Old treated rats showed increased serum concentrations of EPA and DHA and decreased HOMA-IR index and circulating levels of total cholesterol, insulin and IL-6. Treatment with the oil mixture increased the mRNA levels of antioxidant and insulin sensitivity-related enzymes, as well as reduced the gene expression of pro-inflammatory markers in the liver and in cardiac and aortic tissues. In addition, the treatment also prevented the aging-induced endothelial dysfunction and vascular insulin resistance through activation of the PI3K/Akt pathway. Moreover, aortic rings from old rats treated with the oil mixture showed a decreased response to the vasoconstrictor AngII. In conclusion, treatment with a mixture of EVOO and AO improves the lipid profile, insulin sensitivity and vascular function in aged rats and decreases aging-induced inflammation and oxidative stress in the liver, and in the cardiovascular system. Thus, it could be an interesting strategy to deal with cardiometabolic alterations associated with aging.
- Published
- 2020
- Full Text
- View/download PDF
87. Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor
- Author
-
Begoña Alburquerque-González, Fernando F. López-Calderón, María Dolores López-Abellán, Ángel Esteban-Gil, José García-Solano, and Pablo Conesa-Zamora
- Subjects
colorectal cancer ,serrated adenocarcinoma ,angiogenesis ,immune response ,invasive front ,molecular targets ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Serrated adenocarcinoma (SAC) is a tumor recognized by the WHO as a histological subtype accounting for around 9% of colorectal carcinomas. Compared to conventional carcinomas, SACs are characterized by a worse prognosis, weak development of the immune response, an active invasive front and a frequent resistance to targeted therapy due to a high occurrence of KRAS or BRAF mutation. Nonetheless, several high-throughput studies have recently been carried out unveiling the biology of this cancer and identifying potential molecular targets, favoring a future histologically based treatment. This review revises the current evidence, aiming to propose potential molecular targets and specific treatments for this aggressive tumor.
- Published
- 2020
- Full Text
- View/download PDF
88. Approaches and Perspectives About Biodiesel and Oil Production Using Algae in Mexico
- Author
-
Rodriguez, Rafael Riosmena, Arredondo-Vega, Bertha Olivia, Granados, Teodoro Reynoso, Cordoba, Miguel, Vivas, Juan Manuel López, Lopez-Calderon, Jorge Manuel, Gordon, Richard, editor, and Seckbach, Joseph, editor
- Published
- 2012
- Full Text
- View/download PDF
89. Efecto del ciclo de producción sobre el potencial de rendimiento y calidad nutricional del maíz forrajero en la Comarca Lagunera
- Author
-
Granados-Niño, Jorge Alberto, primary, Sánchez-Duarte, Juan Isidro, additional, Ochoa-Martínez, Esmeralda, additional, Rodríguez-Hernández, Karla, additional, Reta-Sánchez, David Guadalupe, additional, and López-Calderón, Magali Jeaneth, additional
- Published
- 2022
- Full Text
- View/download PDF
90. Composición nutritiva y productividad de forrajes alternativos de otoño-invierno en diferentes fechas de siembra del norte de México
- Author
-
López-Jara, Anabel Guadalupe, primary, Reta-Sánchez, David Guadalupe, additional, Reyes-González, Arturo, additional, Santana, Omar Iván, additional, López-Calderón, Magali Jeaneth, additional, and Sánchez-Duarte, Juan Isidro, additional
- Published
- 2022
- Full Text
- View/download PDF
91. La secuencia didáctica como estrategia pedagógica para abordar la oralidad a través de la atención visual
- Author
-
Kelly Johanna Ballén Parada, Gina Magali López Calderón, and Martha Isabel Mora Galeano
- Abstract
Este artículo presenta los resultados de la investigación “Secuencia didáctica basada en la atención visual para abordar la oralidad en grado primero”, que se enmarca en el enfoque cualitativo de tipo Investigación Acción (IA), la cual se desarrolló en tres fases importantes: la primera, selección de muestra de la población y la caracterización de estudiantes de la Institución Educativa Distrital Sierra Morena; la segunda, establecimiento de categorías que permitieron relacionar la realidad observada con campos de la investigación: oralidad y atención visual; y, en tercer lugar, el diseño de la secuencia didáctica “El baúl que habla y encanta”, como resultado obtenido dentro de la investigación y que permitió llegar a las conclusiones de tipo reflexivo frente a las prácticas pedagógicas. Lo anterior da respuesta a la pregunta de la investigación planteada: ¿Qué estrategia pedagógica permite abordar la oralidad desde la atención visual?
- Published
- 2021
92. Arthritis-Induced Anorexia and Muscle Wasting
- Author
-
Martín, Ana Isabel, primary and López-Calderón, Asunción, additional
- Published
- 2017
- Full Text
- View/download PDF
93. Wing morphology covaries with migration distance in a highly aerial insectivorous songbird.
- Author
-
Matyjasiak, Piotr, López-Calderón, Cosme, Ambrosini, Roberto, Balbontín, Javier, Costanzo, Alessandra, Kiat, Yosef, Romano, Andrea, and Rubolini, Diego
- Subjects
- *
BIRD migration , *MORPHOLOGY , *SONGBIRDS , *FORAGING behavior , *BARN swallow , *HABITAT selection , *INSECT flight - Abstract
According to classical prediction of aerodynamic theory, birds and other powered fliers that migrate over long distances should have longer and more pointed wings than those that migrate less. However, the association between wing morphology and migratory behavior can be masked by contrasting selective pressures related to foraging behavior, habitat selection and predator avoidance, possibly at the cost of lower flight energetic efficiency. We studied the handwing morphology of Eurasian barn swallows Hirundo rustica from four populations representing a migration distance gradient. This species is an aerial insectivore, so it flies extensively while foraging, and may migrate during the day using a 'fly-and-forage' migration strategy. Prolonged foraging flights may reinforce the effects of migration distance on flight morphology. We found that two wings' aerodynamic properties—isometric handwing length and pointedness, both favoring energetically efficient flight, were more pronounced in barn swallows from populations undertaking longer seasonal migrations compared to less migratory populations. Our result contrast with two recent interspecific comparative studies that either reported no relationship or reported a negative relationship between pointedness and the degree of migratory behavior in hirundines. Our results may thus contribute to confirming the universality of the rule that longer migrations are associated with more pointed wings. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
94. Validating the Spanish Adverse Childhood Experiences International Questionnaire (ACE-IQ): A Mexican Analysis.
- Author
-
Téllez, Arnoldo, Almaraz-Castruita, Diana Aracely, Valdez, Arturo, Juárez-García, Dehisy Marisol, de Jesús Sánchez-Jáuregui, Teresa, Hinojosa Fernández, Rogelio, López Calderón, Shayam Fernanda, and García Balvaneda, Hugo
- Subjects
ADVERSE childhood experiences ,MEXICAN Americans ,RESEARCH methodology evaluation ,CROSS-sectional method ,CRONBACH'S alpha ,DESCRIPTIVE statistics ,FACTOR analysis ,MENTAL depression ,ANXIETY ,PSYCHOLOGICAL stress - Abstract
Existing literature shows that adverse childhood experiences (ACEs) lead to both physical and psychological chronic health conditions and affect individuals' overall well-being in adulthood. This study aimed to adapt and validate the Adverse Childhood Experiences International Questionnaire (ACE-IQ) in Spanish in the context of the Mexican population. A cross-sectional research design was adopted based on the World Health Organization guidelines using back translation, expert evaluation, and a target population pilot application; the finalized version obtained was applied to 917 subjects, 79% of whom were women. Exploratory factor analysis yielded five factors with adequate internal consistency: Household violence, sexual abuse, family dysfunction, peer violence, and community violence. The Kaiser–Meyer–Olkin sample adequacy measure and Bartlett's sphericity test were applied. The Cronbach's alpha values for reliability were.86,.90,.72,.69, and.69 for factors one (family violence; six items), two (sexual abuse; four items), three (peer violence; seven items), four (family dysfunction; seven items), and five (community violence; seven items), respectively. Each factor was positively and significantly associated with anxiety, depression, and stress. Factors such as peer violence and family dysfunction were negatively correlated with optimism levels. This first Mexican version of ACE-IQ (ACE-IQMx) shows adequate psychometric validity for future research; however, research should continue in different Hispanic populations to confirm its validity and reliability. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
95. Climate Change Impact on the Habitat Suitability of Pseudotsuga menziesii Mirb. Franco in Mexico: An Approach for Its Conservation
- Author
-
Aldo Rafael Martínez-Sifuentes, José Antonio Hernández-Herrera, Luis Manuel Valenzuela-Núñez, Edwin Amir Briceño-Contreras, Ulises Manzanilla-Quiñones, Argel Gastélum-Arellánez, Ramón Trucíos-Caciano, and Magali Jeaneth López Calderón
- Subjects
Renewable Energy, Sustainability and the Environment ,Geography, Planning and Development ,climate change ,habitat suitability ,MaxEnt ,Pseudotsuga menziesii ,Building and Construction ,Management, Monitoring, Policy and Law - Abstract
One of the conifers that survived after the last glaciation is the Pseudotsuga menziesii (Mirb.) Franco. Due to the gradual increase in temperature, this species was forced to move from the south to the north and to higher elevation, causing a fragmented and intermittent distribution in Mexico. The main objective of this study was to model and identify suitable areas for the future conservation of the P. menziesii in Mexico. The specific objectives of this research were: (i) to model the habitat suitability of P. menziesii in Mexico, (ii) to identify the most relevant environmental variables based on its current and future habitat suitability (2030, 2050, 2070 and 2090) and (iii) to suggest areas for the conservation of the species in Mexico. Records were compiled from different national and international sources. Climate and topographic variables were used. With MaxEnt software version 3.4.3 (Phillips, New York, NY, USA) 100 distribution models were obtained, where the model showed an area under the curve of 0.905 for training and 0.906 for validation and partial ROC of 1.95 and Z reliable (p < 0.01), with TSS values > 0.80. The current area of the P. menziesii was 31,580.65 km2. The most important variables in the current and future distribution were maximum temperature of the hottest month, precipitation of the coldest trimester and average temperature of the coldest trimester. The percentage of permanence (resilience) for the 2030, 2050, 2070 and 2090 climate horizons was 49.79%, 25.14%, 17.45% and 16.46%, respectively, for the SSP 245 scenario. On the other hand, for the SSP 585 scenario and the analyzed horizons, the percentage resilience in areas of suitable habitat zones was 41.45%, 27.42%, 9.82% and 2.89%.
- Published
- 2022
- Full Text
- View/download PDF
96. Wing morphology covaries with migration distance in a highly aerial insectivorous songbird
- Author
-
Piotr Matyjasiak, Cosme López-Calderón, Roberto Ambrosini, Javier Balbontín, Alessandra Costanzo, Yosef Kiat, Andrea Romano, Diego Rubolini, Universidad de Sevilla. Departamento de Zoología, Junta de Andalucía, National Science Centre, and European Union
- Subjects
Migration syndrome ,Flight Morphology ,Wing shape ,Geographical differences ,Population ,Hirundo rustica ,Animal Science and Zoology - Abstract
According to classical prediction of aerodynamic theory, birds and other powered fliers that migrate over long distances should have longer and more pointed wings than those that migrate less. However, the association between wing morphology and migratory behavior can be masked by contrasting selective pressures related to foraging behavior, habitat selection and predator avoidance, possibly at the cost of lower flight energetic efficiency. We studied the handwing morphology of Eurasian barn swallows Hirundo rustica from four populations representing a migration distance gradient. This species is an aerial insectivore, so it flies extensively while foraging, and may migrate during the day using a ‘fly-and-forage’ migration strategy. Prolonged foraging flights may reinforce the effects of migration distance on flight morphology. We found that two wings’ aerodynamic properties—isometric handwing length and pointedness, both favoring energetically efficient flight, were more pronounced in barn swallows from populations undertaking longer seasonal migrations compared to less migratory populations. Our result contrast with two recent interspecific comparative studies that either reported no relationship or reported a negative relationship between pointedness and the degree of migratory behavior in hirundines. Our results may thus contribute to confirming the universality of the rule that longer migrations are associated with more pointed wings. Junta de Andalucía P12-RNM-2144 National Science Centre DEC-2013/09/B/NZ8/03321 European Union 1062
- Published
- 2022
97. The Mitogenome Relationships and Phylogeography of Barn Swallows (Hirundo rustica)
- Author
-
Gianluca Lombardo, Nicola Rambaldi Migliore, Giulia Colombo, Marco Rosario Capodiferro, Giulio Formenti, Manuela Caprioli, Elisabetta Moroni, Leonardo Caporali, Hovirag Lancioni, Simona Secomandi, Guido Roberto Gallo, Alessandra Costanzo, Andrea Romano, Maria Garofalo, Cristina Cereda, Valerio Carelli, Lauren Gillespie, Yang Liu, Yosef Kiat, Alfonso Marzal, Cosme López-Calderón, Javier Balbontín, Timothy A. Mousseau, Piotr Matyjasiak, Anders Pape Møller, Ornella Semino, Roberto Ambrosini, Andrea Bonisoli-Alquati, Diego Rubolini, Luca Ferretti, Alessandro Achilli, Luca Gianfranceschi, Anna Olivieri, Antonio Torroni, Lombardo G., Rambaldi Migliore N., Colombo G., Capodiferro M.R., Formenti G., Caprioli M., Moroni E., Caporali L., Lancioni H., Secomandi S., Gallo G.R., Costanzo A., Romano A., Garofalo M., Cereda C., Carelli V., Gillespie L., Liu Y., Kiat Y., Marzal A., Lopez-Calderon C., Balbontin J., Mousseau T.A., Matyjasiak P., Moller A.P., Semino O., Ambrosini R., Bonisoli-Alquati A., Rubolini D., Ferretti L., Achilli A., Gianfranceschi L., Olivieri A., and Torroni A.
- Subjects
Settore BIO/07 - Ecologia ,haplogroup ,Hirundo rustica subspecie ,Asia ,mitogenome ,Animal ,barn swallow phylogeny ,mitochondrial ,Phylogeography ,Swallows ,Hirundo rustica subspecies ,haplogroups ,Africa ,animals ,female ,humans ,phylogeography ,genome, mitochondrial ,swallows ,Genome, Mitochondrial ,Genetics ,Animals ,Humans ,Female ,genome ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Human - Abstract
The barn swallow (Hirundo rustica) poses a number of fascinating scientific questions, including the taxonomic status of postulated subspecies. Here, we obtained and assessed the sequence variation of 411 complete mitogenomes, mainly from the European H. r. rustica, but other subspecies as well. In almost every case, we observed subspecies-specific haplogroups, which we employed together with estimated radiation times to postulate a model for the geographical and temporal worldwide spread of the species. The female barn swallow carrying the Hirundo rustica ancestral mitogenome left Africa (or its vicinity) around 280 thousand years ago (kya), and her descendants expanded first into Eurasia and then, at least 51 kya, into the Americas, from where a relatively recent (
- Published
- 2022
98. Flujo de efectivo como herramienta de control financiero para el sector pyme: una revisión sistemática
- Author
-
López Calderón, Diego Nicolás, Linero Maldonado, Laura, and Castro Garzón, Lina María
- Subjects
Pequeña y mediana empresa ,Finanzas ,Administración - Abstract
figuras, tablas ; 28 cm. La presente revisión sistemática expone la importancia de las herramientas para control financiero en el sector PYME en Colombia, teniendo en cuenta el aporte de estas empresas en el sector económico del país y así mismo un análisis de las causas de fracaso que se presentan para sobrevivir en el mercado a través del tiempo. Por medio de la investigación de varios artículos científicos basado en la evolución de teorías científicas de diferentes autores, sobre un adecuado manejo administrativo y control del dinero en efectivo; se contextualiza sobre herramientas contables que permite desarrollar y aplicar un proceso eficiente, tanto en el manejo de la liquidez como en facilitar las decisiones estratégicas acertadas, por medio de un análisis del Flujo de Caja como herramienta y su influencia en el futuro de las PYMES del país. Consideraciones generales.-- Pregunta de investigación.-- Objetivo de investigación.-- Justificación.-- Marco referencial.-- Metodología.-- Resultados.-- Conclusiones.-- Recomendaciones.-- Bibliografía. Especialización Especialista en Gerencia Financiera Especialización en Gerencia Financiera
- Published
- 2022
99. Climate Change Impact on the Habitat Suitability of Pseudotsuga menziesii Mirb. Franco in Mexico: An Approach for Its Conservation
- Author
-
Martínez-Sifuentes, Aldo Rafael, primary, Hernández-Herrera, José Antonio, additional, Valenzuela-Núñez, Luis Manuel, additional, Briceño-Contreras, Edwin Amir, additional, Manzanilla-Quiñones, Ulises, additional, Gastélum-Arellánez, Argel, additional, Trucíos-Caciano, Ramón, additional, and López Calderón, Magali Jeaneth, additional
- Published
- 2022
- Full Text
- View/download PDF
100. A Nutraceutical Product Based on a Mixture of Algae and Extra Virgin Olive Oils and Olive Leaf Extract Attenuates Sepsis-Induced Cardiovascular and Muscle Alterations in Rats
- Author
-
González-Hedström, Daniel, primary, Moreno-Rupérez, Álvaro, additional, de la Fuente-Fernández, María, additional, de la Fuente-Muñoz, Mario, additional, Román-Carmena, Marta, additional, Amor, Sara, additional, García-Villalón, Ángel Luís, additional, López-Calderón, Asunción, additional, Isabel Martín, Ana, additional, Priego, Teresa, additional, and Granado, Miriam, additional
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.