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436 results on '"Kyriakides, Tassos"'

51. 809: LONGTERM ANNUAL AND BIENNIAL FECAL IMMUNOCHEMICAL TEST (FIT) ADHERENCE IN A MULTI-CENTER STUDY OF COLORECTAL CANCER (CRC) SCREENING

Author

Dominitz, Jason A., primary, Robertson, Douglas J., additional, Beed, Alexander, additional, Boardman, Kathy D., additional, Curto, Barbara Del, additional, Gupta, Samir, additional, Imperiale, Thomas F., additional, Lacasse, Andrew J., additional, Larson, Meaghan F., additional, Lieberman, David A., additional, Shaukat, Aasma, additional, Sultan, Shahnaz, additional, Planeta, Beata M., additional, Williams, Alicia M., additional, and Kyriakides, Tassos, additional

Published
2022
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52. Clinical Variables Correlate with Serum Neutralizing Antibody Titers after COVID-19 mRNA Vaccination in an Adult, US-based Population

Author

Zhao, Min, primary, Slotkin, Rebecca, additional, Sheth, Amar H., additional, Pischel, Lauren, additional, Kyriakides, Tassos C., additional, Emu, Brinda, additional, McNamara, Cynthia, additional, Shi, Qiaosu, additional, Delgobbo, Jaden, additional, Xu, Jin, additional, Marhoffer, Elizabeth, additional, Mercer-Falkoff, Aleagia, additional, Holleck, Jürgen, additional, Ardito, David, additional, Sutton, Richard E., additional, and Gupta, Shaili, additional

Published
2022
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54. Segmentation-free PVC for Cardiac SPECT using a Densely-connected Multi-dimensional Dynamic Network

Author

Xie, Huidong, primary, Liu, Zhao, additional, Shi, Luyao, additional, Greco, Kathleen, additional, Chen, Xiongchao, additional, Zhou, Bo, additional, Feher, Attila, additional, Stendahl, John C., additional, Boutagy, Nabil, additional, Kyriakides, Tassos C., additional, Wang, Ge, additional, Sinusas, Albert J., additional, and Liu, Chi, additional

Published
2022
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55. Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population.

Author

Zhao, Min, Slotkin, Rebecca, Sheth, Amar H, Pischel, Lauren, Kyriakides, Tassos C, Emu, Brinda, McNamara, Cynthia, Shi, Qiaosu, Delgobbo, Jaden, Xu, Jin, Marhoffer, Elizabeth, Mercer-Falkoff, Aleagia, Holleck, Jürgen, Ardito, David, Sutton, Richard E, and Gupta, Shaili

Subjects
EVALUATION of medical care, IMMUNOGLOBULINS, COVID-19, IMMUNIZATION, COVID-19 vaccines, MULTIPLE regression analysis, TIME, MESSENGER RNA, QUALITY of life, IMMUNITY, DESCRIPTIVE statistics, RESEARCH funding, VIRAL antibodies, COMORBIDITY
Abstract

Background We studied whether comorbid conditions affect strength and duration of immune responses after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA vaccination in a US-based, adult population. Methods Sera (before and after BNT162b2 vaccination) were tested serially up to 12 months after 2 doses of vaccine for SARS-CoV-2-anti-Spike neutralizing capacity by pseudotyping assay in 124 individuals; neutralizing titers were correlated to clinical variables with multivariate regression. Postbooster (third dose) effect was measured at 1 and 3 months in 72 and 88 subjects, respectively. Results After completion of primary vaccine series, neutralizing antibody half maximal inhibitory concentration (IC50) values were high at 1 month (14-fold increase from prevaccination), declined at 6 months (3.3-fold increase), and increased at 1 month postbooster (41.5-fold increase). Three months postbooster, IC50 decreased in coronavirus disease (COVID)-naïve individuals (18-fold increase) and increased in prior COVID 2019 (COVID-19+) individuals (132-fold increase). Age >65 years (β = −0.94, P =.001) and malignancy (β = −0.88, P =.002) reduced strength of response at 1 month. Both neutralization strength and durability at 6 months, respectively, were negatively affected by end-stage renal disease ([β = −1.10, P =.004]; [β = −0.66, P =.014]), diabetes mellitus ([β = −0.57, P =.032]; [β = −0.44, P =.028]), and systemic steroid use ([β = −0.066, P =.032]; [β = −0.55, P =.037]). Postbooster IC50 was robust against WA-1 and B.1.617.2. Postbooster neutralization increased with prior COVID-19 (β = 2.9, P <.0001), and malignancy reduced neutralization response (β = −0.68, P =.03), regardless of infection status. Conclusions Multiple clinical factors affect the strength and duration of neutralization response after primary series vaccination, but not the postbooster dose strength. Malignancy was associated with lower booster-dose response regardless of prior COVID infection, suggesting a need for clinically guided vaccine regimens. [ABSTRACT FROM AUTHOR]

Published
2023
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58. Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory

Author

Ali, Joseph, primary, Antonelli, Margaret, additional, Bastian, Lori, additional, Becker, William, additional, Brandt, Cynthia A, additional, Burgess, Diana J, additional, Burns, Amy, additional, Cohen, Steven P, additional, Davis, Alison F, additional, Dearth, Christopher L, additional, Dziura, Jim, additional, Edwards, Rob, additional, Erdos, Joe, additional, Farrokhi, Shawn, additional, Fritz, Julie, additional, Geda, Mary, additional, George, Steven Z, additional, Goertz, Christine, additional, Goodie, Jeffrey, additional, Hastings, Susan N, additional, Heapy, Alicia, additional, Ilfeld, Brian M, additional, Katsovich, Lily, additional, Kerns, Robert D, additional, Kyriakides, Tassos C, additional, Lee, Allison, additional, Long, Cynthia R, additional, Luther, Stephen L, additional, Martino, Steve, additional, Matheny, Michael E, additional, McGeary, Don, additional, Midboe, Amanda, additional, Pasquina, Paul, additional, Peduzzi, Peter, additional, Raffanello, Michael, additional, Rhon, Daniel, additional, Rosen, Marc, additional, Esposito, Elizabeth Russell, additional, Scarton, Dylan, additional, Seal, Karen, additional, Silliker, Norman, additional, Taylor, Sakasha, additional, Taylor, Stephanie L, additional, Tsui, Megan, additional, Wright, Fred S, additional, and Zeliadt, Steven, additional

Published
2021
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63. Familial Mediterranean Fever Associated with MEFV Mutations in a Large Cohort of Cypriot Patients

Author

Neocleous, Vassos, Costi, Constantina, Kyriakou, Christina, Kyriakides, Tassos C, Shammas, Christos, Skordis, Nicos, Toumba, Meropi, Kyriakou, Sophia, Koliou, Maria, Kousparou, Marianna, Onoufriou, Margarita, Hadjipanayis, Adamos, Iasonides, Michalis, Atamyan, Vick N, Pierides, Alkis, Christophidou-Anastasiadou, Violetta, Tanteles, George A, and Phylactou, Leonidas A

Published
2015
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64. Generation of parametric K i images for FDG PET using two 5‐min scans

Author

Wu, Jing, primary, Liu, Hui, additional, Ye, Qing, additional, Gallezot, Jean‐Dominique, additional, Naganawa, Mika, additional, Miao, Tianshun, additional, Lu, Yihuan, additional, Chen, Ming‐Kai, additional, Esserman, Denise A., additional, Kyriakides, Tassos C., additional, Carson, Richard E., additional, and Liu, Chi, additional

Published
2021
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65. miR-223-3p and miR-24-3p as novel serum-based biomarkers for myotonic dystrophy type 1

Author

Koutalianos, Demetris Koutsoulidou, Andrie Mytidou, Chrystalla and Kakouri, Andrea C. Oulas, Anastasis Tomazou, Marios and Kyriakides, Tassos C. Prokopi, Marianna Kapnisis, Konstantinos and Nikolenko, Nikoletta Turner, Chris Lusakowska, Anna and Janiszewska, Katarzyna Papadimas, George K. Papadopoulos, Constantinos Kararizou, Evangelia Spyrou, George M. Gourdon, Genevieve Papanicolaou, Eleni Zamba Gorman, Grainne and Anayiotos, Andreas Lochmueller, Hanns Phylactou, Leonidas A.

Subjects
musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities
Abstract

Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy, primarily characterized by muscle wasting and weakness. Many biomarkers already exist in the rapidly developing biomarker research field that aim to improve patients' care. Limited work, however, has been performed on rare diseases, including DM1. We have previously shown that specific microRNAs (miRNAs) can be used as potential biomarkers for DM1 progression. In this report, we aimed to identify novel serum-based biomarkers for DM1 through high-throughput next-generation sequencing. A number of miRNAs were identified that are able to distinguish DM1 patients from healthy individuals. Two miRNAs were selected, and their association with the disease was validated in a larger panel of patients. Further investigation of miR-223-3p, miR-24-3p, and the four previously identified miRNAs, miR-1-3p, miR-133a-3p, miR133b-3p, and miR-206-3p, showed elevated levels in a DM1 mouse model for all six miRNAs circulating in the serum compared to healthy controls. Importantly, the levels of miR-223-3p, but not the other five miRNAs, were found to be significantly downregulated in five skeletal muscles and heart tissues of DM1 mice compared to controls. This result provides significant evidence for its involvement in disease manifestation.

Published
2021

70. Segmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network

Author

Xie, Huidong, Liu, Zhao, Shi, Luyao, Greco, Kathleen, Chen, Xiongchao, Zhou, Bo, Feher, Attila, Stendahl, John C., Boutagy, Nabil, Kyriakides, Tassos C., Wang, Ge, Sinusas, Albert J., and Liu, Chi

Abstract

In nuclear imaging, limited resolution causes partial volume effects (PVEs) that affect image sharpness and quantitative accuracy. Partial volume correction (PVC) methods incorporating high-resolution anatomical information from CT or MRI have been demonstrated to be effective. However, such anatomical-guided methods typically require tedious image registration and segmentation steps. Accurately segmented organ templates are also hard to obtain, particularly in cardiac SPECT imaging, due to the lack of hybrid SPECT/CT scanners with high-end CT and associated motion artifacts. Slight mis-registration/mis-segmentation would result in severe degradation in image quality after PVC. In this work, we develop a deep-learning-based method for fast cardiac SPECT PVC without anatomical information and associated organ segmentation. The proposed network involves a densely-connected multi-dimensional dynamic mechanism, allowing the convolutional kernels to be adapted based on the input images, even after the network is fully trained. Intramyocardial blood volume (IMBV) is introduced as an additional clinical-relevant loss function for network optimization. The proposed network demonstrated promising performance on 28 canine studies acquired on a GE Discovery NM/CT 570c dedicated cardiac SPECT scanner with a 64-slice CT using Technetium-99m-labeled red blood cells. This work showed that the proposed network with densely-connected dynamic mechanism produced superior results compared with the same network without such mechanism. Results also showed that the proposed network without anatomical information could produce images with statistically comparable IMBV measurements to the images generated by anatomical-guided PVC methods, which could be helpful in clinical translation.

Published
2023
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71. Outcomes following endovascular vs open repair of abdominal aortic aneurysm

Author

Lederle, Frank A., Freischlag, Julie A., Kyriakides, Tassos C., Padberg, Frank T. Jr., Matsumura, Jon S., Kohler, Ted R., Lin, Peter H., Jean-Claude, Jessie M., Cikrit, Dolores F., Swanson, Kathleen M., and Peduzzi, Peter N.

Subjects
Abdominal aneurysm -- Care and treatment, Minimally invasive surgery -- Patient outcomes, Perioperative care -- Evaluation, Medical care -- Needs assessment, Needs assessment
Abstract

A study was conducted to evaluate and compare the outcomes in patients following endovascular or open repair of abdominal aortic aneurysm (AAA). Results indicated that perioperative mortality was found to be lower in the case of endovascular as compared to open repair of AAA.

Published
2009

73. 258 THE ASSOCIATION OF RACE AND ETHNICITY ON PRIOR COLORECTAL CANCER SCREENING TEST USE IN A LARGE CLINICAL TRIAL OF US VETERANS

Author

Robertson, Douglas J., primary, Dominitz, Jason A., additional, Beed, Alexander, additional, Williams, Alicia, additional, Boardman, Kathy D., additional, Imperiale, Thomas F., additional, Lieberman, David A., additional, Provenzale, Dawn, additional, Shaukat, Aasma, additional, Sultan, Shahnaz, additional, and Kyriakides, Tassos, additional

Published
2021
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75. Costs of repair of abdominal aortic aneurysm with different devices in a multicenter randomized trial

Author

Matsumura, Jon S., Stroupe, Kevin T., Lederle, Frank A., Kyriakides, Tassos C., Ge, Ling, Freischlag, Julie A., Ketteler, Erika R., Kingsley, Darra D., Marek, John M., Massen, Richard J., Matteson, Brian D., Pitcher, David J., Langsfeld, Mark, Corson, John D., Goff, James M., Jr., Kasirajan, Karthnik, Paap, Christina, Robertson, Diane C., Salam, Atef, Veeraswamy, Ravi, Milner, Ross, Kasirajan, Karthikeshwar, Guidot, Jane, Lal, Brajesh K., Busuttil, Steven J., Lilly, Michael P., Braganza, Melita, Ellis, Kea, Patterson, Mark A., Jordan, William D., Whitley, David, Taylor, Steve, Passman, Marc, Kerns, Donna, Inman, Cindy, Poirier, Jennifer, Ebaugh, James, Raffetto, Joseph, Chew, David, Lathi, Subhash, Owens, Christopher, Hickson, Kathleen, Dosluoglu, Hasan H., Eschberger, Karen, Kibbe, Melina R., Baraniewski, Henry M., Matsumura, Jon, Endo, Michelle, Busman, Anna, Meadows, Wendy, Evans, Mary, Giglia, Joseph S., El Sayed, Hosam, Reed, Amy B., Ruf, Madeline, Ross, Stephanie, Jean-Claude, Jessie M., Pinault, Gilles, Kang, Preet, White, Nadine, Eiseman, Matthew, Jones, Reba, Timaran, Carlos H., Modrall, Gregory J., Welborn, Burress M., III, Lopez, Jorge, Nguyen, Tammy, Chacko, John K.Y., Granke, Kenneth, Vouyouka, Angela G., Olgren, Erin, Chand, Prakash, Allende, Brenda, Ranella, Michael, Yales, Claudia, Whitehill, Thomas A., Krupski, William C., Nehler, Mark R., Johnson, Stephen P., Jones, Darrell N., Strecker, Pamela, Bhola, Michelle A., Shortell, Cynthia K., Gray, John L., Lawson, Jeffrey H., McCann, Richard, Sebastian, Mark W., Tetterton, Jean Kistler, Blackwell, Carla, Prinzo, Patricia A., Lee, Nina, Padberg, Frank T., Jr., Cerveira, Joaquim J., Zickler, Robert W., Hauck, Karen A., Berceli, Scott A., Lee, Anthony W., Ozaki, Keith C., Nelson, Peter R., Irwin, Anne S., Baum, Randy, Aulivola, Bernadette, Rodriguez, Heron, Littooy, Fred N., Greisler, Howard, OʼSullivan, Mary T., Kougias, Panagiotis, Lin, Peter H., Bush, Ruth L., Guinn, Gene, Cagiannos, Catherine, Pillack, Sherilyn, Guillory, Barbara, Cikrit, Dolores, Lalka, Stephen G., Lemmon, Gary, Nachreiner, Ryan, Rusomaroff, Mitzi, OʼBrien, Elaine, Cullen, Joseph J., Hoballah, Jamal, Sharp, John W., McCandless, Jeanne L., Beach, Vickie, Minion, David, Schwarcz, Thomas H., Kimbrough, Joy, Ashe, Laura, Rockich, Anna, Warner-Carpenter, Jill, Moursi, Mohammed, Eidt, John F., Brock, Sandra, Bianchi, Christian, Bishop, Vicki, Gordon, Ian L., Fujitani, Roy, Kubaska, Stephen M., III, Behdad, Mina, Azadegan, Reza, Agas, Christine Ma, Zalecki, Kathy, Hoch, John R., Carr, Sandra C., Acher, Charles, Schwarze, Margaret, Tefera, Girma, Mell, Matthew, Dunlap, Beth, Rieder, Janice, Stuart, John M., Weiman, Darryl S., Abul-Khoudoud, Omran, Garrett, Edward H., Walsh, Sandra M., Wilson, Karen L., Seabrook, Gary R., Cambria, Robert A., Brown, Kellie R., Lewis, Brian D., Framberg, Susan, Kallio, Christa, Barke, Roderick A., Santilli, Steven M., dʼAudiffret, Alexandre C., Oberle, Nancy, Proebstle, Catherine, Lee Johnson, Lauri, Jacobowitz, Glenn R., Cayne, Neal, Rockman, Caron, Adelman, Mark, Gagne, Paul, Nalbandian, Matthew, Caropolo, Leah J., Pipinos, Iraklis I., Johanning, Jason, Lynch, Thomas, DeSpiegelaere, Holly, Purviance, Georgia, Zhou, Wei, Dalman, Ronald, Lee, Jason T., Safadi, Bassem, Coogan, Sheila M., Wren, Sherry M., Bahmani, Doghdoo D., Maples, Deanna, Thunen, Shawna, Golden, Michael A., Mitchell, Marc E., Fairman, Ronald, Reinhardt, Sally, Wilson, Mark A., Tzeng, Edith, Muluk, Satish, Peterson, Nina M., Foster, Maria, Edwards, James, Moneta, Gregory L., Landry, Gregory, Taylor, Lloyd, Yeager, Richard, Cannady, Eleanor, Treiman, Gerald, Hatton-Ward, Stephanie, Salabsky, Barbara, Owens, Erik, Forbes, Beth A., Rapp, Joseph H., Reilly, Linda M., Perez, Sandra L., Yan, Kimberly, Sarkar, Rajaabrata, Dwyer, Shelley S., Kohler, Ted R., Hatsukami, Thomas S., Glickerman, David G., Sobel, Michael, Burdick, Thomas S., Pedersen, Kimberly, Cleary, Patricia, Kansal, Nikhil, Estes, Melanie, Sobotta, Cinda, Back, Martin, Bandyk, Dennis, Johnson, Brad, Shames, Murray, Reinhard, Rebecca L., Thomas, Sandra C., Hunter, Glenn C., Leon, Luis R., Jr., Westerband, Alex, Guerra, Robert J., Riveros, Macario, Mills, John L., Sr., Hughes, John D., Escalante, Andrea M., Psalms, Shemuel B., Day, Nancy N., Macsata, Robyn, Sidawy, Anton, Weiswasser, Jonathan, Arora, Subodh, Jasper, Brenda J., Dardik, Alan, Gahtan, Vivian, Muhs, Bart E., Sumpio, Bauer E., Gusberg, Richard J., Spector, Marcelo, Pollak, Jeffrey, Aruny, John, Kelly, Lynne E., Wong, James, Vasilas, Penny, Joncas, Carmelene, Gelabert, Hugh A., DeVirgillio, Christian, Rigberg, David A., and Cole, Loretta

Published
2015
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81. Development and application of a genotypic AZT resistance assay: quantitative assessment of the resistance profile of clinical samples and the relative predictive ability of a resistance index

Author

Kyriakides, Tassos C. and Heimer, Robert R.

Subjects
Microbial sensitivity tests -- Evaluation, Drug resistance in microorganisms -- Testing, HIV (Viruses), Health
Abstract

An assay is described that can determine whether a strain of HIV is resistant to AZT. The assay could also be used to detect other types of drug resistance in HIV. Doctors could use the assay to decide which AIDS drug to use for any individual patient.

Published
2001

83. Mo1626 SERRATED POLYP FINDINGS ON SCREENING COLONOSCOPY IN A MULTI-CENTER STUDY OF COLORECTAL CANCER SCREENING

Author

Dominitz, Jason A., primary, Robertson, Douglas J., additional, Beed, Alexander, additional, Ahnen, Dennis, additional, Boardman, Kathy D., additional, Del Curto, Barbara, additional, Guarino, Peter, additional, Imperiale, Thomas F., additional, Johnson, Gary R., additional, Kyriakides, Tassos, additional, LaCasse, Andrew J., additional, Larson, Meaghan F., additional, Lieberman, David A., additional, Provenzale, Dawn, additional, Shaukat, Aasma, additional, Sultan, Shahnaz, additional, and Planeta, Beata M., additional

Published
2020
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86. HIV-1 transmission in injection paraphernalia: heating drug solutions may inactivate HIV-1

Author

Clatts, Michael C., Heimer, Robert, Abdala, Nadia, Goldsamt, Lloyd A., Sotheran, Jo L., Anderson, Kenneth T., Gallo, Toni M., Hoffer, Lee D., Luciano, Pellegrino A., and Kyriakides, Tassos

Subjects
HIV (Viruses) -- Inactivation, Drugs -- Production processes, Health
Abstract

Heating drugs to at least 150 degrees F. for 15 seconds or longer may inactivate HIV. Many drug addicts heat their drugs before injecting them in a device called a cooker.

Published
1999

92. Generation of parametric Ki images for FDG PET using two 5‐min scans.

Author

Wu, Jing, Liu, Hui, Ye, Qing, Gallezot, Jean‐Dominique, Naganawa, Mika, Miao, Tianshun, Lu, Yihuan, Chen, Ming‐Kai, Esserman, Denise A., Kyriakides, Tassos C., Carson, Richard E., and Liu, Chi

Subjects
POSITRON emission tomography, PULMONARY nodules, ABSOLUTE value, BONE marrow, LEAST squares
Abstract

Purpose: The net uptake rate constant (Ki) derived from dynamic imaging is considered the gold standard quantification index for FDG PET. In this study, we investigated the feasibility and assessed the clinical usefulness of generating Ki images for FDG PET using only two 5‐min scans with population‐based input function (PBIF). Methods: Using a Siemens Biograph mCT, 10 subjects with solid lung nodules underwent a single‐bed dynamic FDG PET scan and 13 subjects (five healthy and eight cancer patients) underwent a whole‐body dynamic FDG PET scan in continuous‐bed‐motion mode. For each subject, a standard Ki image was generated using the complete 0–90 min dynamic data with Patlak analysis (t* = 20 min) and individual patient's input function, while a dual‐time‐point Ki image was generated from two 5‐min scans based on the Patlak equations at early and late scans with the PBIF. Different start times for the early (ranging from 20 to 55 min with an increment of 5 min) and late (ranging from 50 to 85 min with an increment of 5 min) scans were investigated with the interval between scans being at least 30 min (36 protocols in total). The optimal dual‐time‐point protocols were then identified. Regions of interest (ROI) were drawn on nodules for the lung nodule subjects, and on tumors, cerebellum, and bone marrow for the whole‐body‐imaging subjects. Quantification accuracy was compared using the mean value of each ROI between standard Ki (gold standard) and dual‐time‐point Ki, as well as between standard Ki and relative standardized uptake value (SUV) change that is currently used in clinical practice. Correlation coefficients and least squares fits were calculated for each dual‐time‐point protocol and for each ROI. Then, the predefined criteria for identifying a reliable dual‐time‐point Ki estimation for each ROI were empirically determined as: (1) the squared correlation coefficient (R2) between standard Ki and dual‐time‐point Ki is larger than 0.9; (2) the absolute difference between the slope of the equality line (1.0) and that of the fitted line when plotting standard Ki versus dual‐time‐point Ki is smaller than 0.1; (3) the absolute value of the intercept of the fitted line when plotting standard Ki versus dual‐time‐point Ki normalized by the mean of the standard Ki across all subjects for each ROI is smaller than 10%. Using Williams' one‐tailed t test, the correlation coefficient (R) between standard Ki and dual‐time‐point Ki was further compared with that between standard Ki and relative SUV change, for each dual‐time‐point protocol and for each ROI. Results: Reliable dual‐time‐point Ki images were obtained for all the subjects using our proposed method. The percentage error introduced by the PBIF on the dual‐time‐point Ki estimation was smaller than 1% for all 36 protocols. Using the predefined criteria, reliable dual‐time‐point Ki estimation could be obtained in 25 of 36 protocols for nodules and in 34 of 36 protocols for tumors. A longer time interval between scans provided a more accurate Ki estimation in general. Using the protocol of 20–25 min plus 80–85 or 85–90 min, very high correlations were obtained between standard Ki and dual‐time‐point Ki (R2 = 0.994, 0.980, 0.971 and 0.925 for nodule, tumor, cerebellum, and bone marrow), with all the slope values with differences ≤0.033 from 1 and all the intercept values with differences ≤0.0006 mL/min/cm3 from 0. The corresponding correlations were much lower between standard Ki and relative SUV change (R2 = 0.673, 0.684, 0.065, 0.246). Dual‐time‐point Ki showed a significantly higher quantification accuracy with respect to standard Ki than relative SUV change for all the 36 protocols (p < 0.05 using Williams' one‐tailed t test). Conclusions: Our proposed approach can obtain reliable Ki images and accurate Ki quantification from dual‐time‐point scans (5‐min per scan), and provide significantly higher quantification accuracy than relative SUV change that is currently used in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2021
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93. Supplemental material for A joint model for recurrent events and a semi-competing risk in the presence of multi-level clustering

Author

Jung, Tae Hyun, Peduzzi, Peter, Allore, Heather, Kyriakides, Tassos C, and Esserman, Denise

Subjects
111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, FOS: Health sciences, FOS: Sociology
Abstract

Supplemental material for A joint model for recurrent events and a semi-competing risk in the presence of multi-level clustering by Tae Hyun Jung, Peter Peduzzi, Heather Allore, Tassos C Kyriakides and Denise Esserman in Statistical Methods in Medical Research

Published
2018
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94. The Spectrum of Genetic Defects in Congenital Adrenal Hyperplasia in the Population of Cyprus: A Retrospective Analysis

Author

Neocleous, Vassos, additional, Fanis, Pavlos, additional, Toumba, Meropi, additional, Stylianou, Charilaos, additional, Picolos, Michalis, additional, Andreou, Elena, additional, Kyriakou, Andreas, additional, Iasonides, Michalis, additional, Nicolaou, Stella, additional, Kyriakides, Tassos C., additional, Tanteles, George A., additional, Skordis, Nicos, additional, and Phylactou, Leonidas A., additional

Published
2019
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97. 688 – Baseline Findings on Screening Colonoscopy in a Multicenter Study of Colorectal Cancer Screening

Author

Dominitz, Jason A., primary, Robertson, Douglas J., additional, Beed, Alexander, additional, Ahnen, Dennis, additional, Boardman, Kathy D., additional, Del Curto, Barbara, additional, Guarino, Peter, additional, Imperiale, Thomas F., additional, Johnson, Gary R., additional, Kyriakides, Tassos, additional, LaCasse, Andrew J., additional, Larson, Meaghan, additional, Lieberman, David A., additional, Provenzale, Dawn, additional, Shaukat, Aasma, additional, Sultan, Shahnaz, additional, and Planeta, Beata M., additional

Published
2019
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98. 690 – Complications of Screening Colonoscopy in a Multi-Center Study of Colorectal Cancer Screening

Author

Robertson, Douglas J., primary, Dominitz, Jason A., additional, Beed, Alexander, additional, Ahnen, Dennis, additional, Boardman, Kathy D., additional, Del Curto, Barbara, additional, Guarino, Peter, additional, Imperiale, Thomas F., additional, Johnson, Gary R., additional, Kyriakides, Tassos, additional, Larson, Meaghan, additional, LaCasse, Andrew J., additional, Lieberman, David A., additional, Provenzale, Dawn, additional, Shaukat, Aasma, additional, Sultan, Shahnaz, additional, and Planeta, Beata M., additional

Published
2019
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100. Identification of exosomal muscle-specific miRNAs in serum of myotonic dystrophy patients relating to muscle disease progress

Author

Koutsoulidou, Andrie Photiades, Marinos Kyriakides, Tassos C. and Georgiou, Kristia Prokopi, Marianna Kapnisis, Konstantinos and Lusakowska, Anna Nearchou, Marianna Christou, Yiolanda and Papadimas, George K. Anayiotos, Andreas Kyriakou, Kyriakos and Kararizou, Evangelia Papanicolaou, Eleni Zamba Phylactou, Leonidas A.

Subjects
musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities
Abstract

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, which is characterised by progressive muscle wasting and the discovery of reliable blood-based biomarkers could be useful for the disease progress monitoring. There have been some reports showing that the presence of specific miRNAs in blood correlates with DM1. In one of these, our group identified four muscle-specific miRNAs, miR-1, miR-133a, miR-133b and miR-206, which correlated with the progression of muscle wasting observed in DM1 patients. The levels of the four muscle-specific miRNAs were elevated in the serum of DM1 patients compared to healthy participants and were also elevated in the serum of progressive muscle wasting DM1 patients compared to disease-stable DM1 patients. The aim of this work was to characterise the ontology of these four muscle-specific miRNAs in the blood circulation of DM1 patients. Here we show that the four muscle-specific miRNAs are encapsulated within exosomes isolated from DM1 patients. Our results show for the first time, the presence of miRNAs encapsulated within exosomes in blood circulation of DM1 patients. More interestingly, the levels of the four exosomal muscle-specific miRNAs are associated with the progression of muscle wasting in DM1 patients. We propose that exosomal muscle-specific miRNAs may be useful molecular biomarkers for monitoring the progress of muscle wasting in DM1 patients. There has been a growing interest regarding the clinical applications of exosomes and their role in prognosis and therapy of various diseases and the above results contribute towards this way.

Published
2017

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