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1,686 results on '"Kurtz J"'

59. Joint IARC/NCI International Cancer Seminar Series Report: expert consensus on future directions for ovarian carcinoma research

Author

Virani, S, Baiocchi, G, Bowtell, D, Cabasag, CJ, Cho, KR, Fortner, RT, Fujiwara, K, Kim, J-W, Kobel, M, Kurtz, J-E, Levine, DA, Menon, U, Norquist, BM, Pharoah, PDP, Sood, AK, Tworoger, ST, Wentzensen, N, Chanock, SJ, Brennan, P, Trabert, B, Virani, S, Baiocchi, G, Bowtell, D, Cabasag, CJ, Cho, KR, Fortner, RT, Fujiwara, K, Kim, J-W, Kobel, M, Kurtz, J-E, Levine, DA, Menon, U, Norquist, BM, Pharoah, PDP, Sood, AK, Tworoger, ST, Wentzensen, N, Chanock, SJ, Brennan, P, and Trabert, B

Abstract

Recently, ovarian cancer research has evolved considerably because of the emerging recognition that rather than a single disease, ovarian carcinomas comprise several different histotypes that vary by etiologic origin, risk factors, molecular profiles, therapeutic approaches and clinical outcome. Despite significant progress in our understanding of the etiologic heterogeneity of ovarian cancer, as well as important clinical advances, it remains the eighth most frequently diagnosed cancer in women worldwide and the most fatal gynecologic cancer. The International Agency for Research on Cancer and the United States National Cancer Institute jointly convened an expert panel on ovarian carcinoma to develop consensus research priorities based on evolving scientific discoveries. Expertise ranged from etiology, prevention, early detection, pathology, model systems, molecular characterization and treatment/clinical management. This report summarizes the current state of knowledge and highlights expert consensus on future directions to continue advancing etiologic, epidemiologic and prognostic research on ovarian carcinoma.

Published
2021

63. Abyssinia's Samuel Johnson: Ethiopian Thought in the Making of an English Author

Author

Kurtz, J. Roger

Subjects
Abyssinia's Samuel Johnson: Ethiopian Thought in the Making of an English Author (Nonfiction work) -- Belcher, Wendy L. -- Book reviews, Literature/writing
Abstract

Abyssinia's Samuel Johnson: Ethiopian Thought in the Making of an English Author BY WENDY L. BELCHER Oxford: Oxford UP, 2012. x + 285 pp. ISBN 9780199793211 cloth. In Abyssinia's Samuel [...]

Published
2015

65. Numerical Predictions for On-Orbit Ionospheric Aerodynamics Torque Experiment

Author

Capon, CJ, Lorrain, P, Smith, B, Brown, M, Kurtz, J, Boyce, RR, Capon, CJ, Lorrain, P, Smith, B, Brown, M, Kurtz, J, and Boyce, RR

Abstract

Accurate modelling of the aerodynamic interaction between the space environment and Low Earth Orbit (LEO) objects improves our ability to understand, predict and control their motion. A neglected aspect of the LEO aerodynamics problem is the charged aerodynamic interaction of these objects with the ionosphere, i.e. ionospheric aerodynamics. This work describes a prospective on-orbit ionospheric aerodynamic experiment (IEX) that aims to improve our fundamental understanding of ionospheric aerodynamics and provide in-situ data to support ground-based experiment and numerical efforts. IEX involves the charged aerodynamic control of a formation of two 6U CubeSats. Through the establishment of an optical inter-satellite link (ISL), ionospheric torques induced through the asymmetric charging of High Voltage Panels (HVP) will be measured via the integrated buildup in reaction wheel (RW) speed required to maintain ISL quality. The purpose of this work is to provide preliminary estimates of RW speed buildups to establish measurement detection threshold and ISL control loop feedback rate requirements for the experiment. Here, induced torque estimates are made using the Particle-in-Cell (PIC)/Direction Simulation Monte Carlo (DSMC) simulations using the PIC-DSMC code, pdFOAM. These torque predictions are applied to a digital twin simulation of the satellite formation featuring couple dynamics, space environment and flight software models using the astrodynamics framework, Basilisk, and in-house space environment interaction analysis tool, rayMAN. Given a 500 km altitude circular orbit with a 42° inclination with ion number densities (n-{i}) ranging between \mathcal{O}(10^{11}-10^{12}) m^{-3}, pdFOAM simulations predicted an induced torque of \mathcal{O}(-0.25)\ \mu Nm given a HVP surface potential (\phi-{P}) of -100 V for both the high and low density cases. An unexpected result was a net thrust prediction for the low-density cases caused by indirect thrust forces that arise f

Published
2020

69. Osteosarcomas of the mandible: multidisciplinary management of a rare tumor of the young adult a cooperative study of the GSF-GETO, Rare Cancer Network, GETTEC/REFCOR and SFCE†

Author

Thariat, J., Schouman, T., Brouchet, A., Sarini, J., Miller, R. C., Reychler, H., Ray-Coquard, I., Italiano, A., Verite, C., Sohawon, S., Bompas, E., Dassonville, O., Salas, S., Aldabbagh, K., Maingon, P., de La MotteRouge, T., Kurtz, J. E., Usseglio, J., Kerbrat, P., Raoul, G., Lotz, J. P., Bar-Sela, G., Brugières, L., Chaigneau, L., Saada, E., Odin, G., Marcy, P. Y., Thyss, A., and Julieron, M.

Published
2013
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98. Dnmt1 has an essential function despite the absence of CpG DNA methylation in the red flour beetle Tribolium castaneum

Author

Schulz, N.K.E. (Nora), Wagner, C.I. (Clara), Ebeling, J. (Julia), Raddatz, G. (Günter), Diddens-de Buhr, M.F. (Maike), Lyko, F. (Frank), Kurtz, J. (Joachim), and Universitäts- und Landesbibliothek Münster

Subjects
ddc:570, embryonic structures, Biology
Abstract

Epigenetic mechanisms, such as CpG DNA methylation enable phenotypic plasticity and rapid adaptation to changing environments. CpG DNA methylation is established by DNA methyltransferases (DNMTs), which are well conserved across vertebrates and invertebrates. There are insects with functional DNA methylation despite lacking a complete set of Dnmts. But at least one of the enzymes, DNMT1, appears to be required to maintain an active DNA methylation system. The red flour beetle, Tribolium castaneum, lacks Dnmt3 but possesses Dnmt1 and it has been controversial whether it has a functional DNA methylation system. Using whole genome bisulfite sequencing, we did not find any defined patterns of CpG DNA methylation in embryos. Nevertheless, we found Dnmt1 expressed throughout the entire life cycle of the beetle, with mRNA transcripts significantly more abundant in eggs and ovaries. A maternal knockdown of Dnmt1 caused a developmental arrest in offspring embryos. We show that Dnmt1 plays an essential role in T. castaneum embryos and that its downregulation leads to an early developmental arrest. This function appears to be unrelated to DNA methylation, since we did not find any evidence for this modification. This strongly suggests an alternative role of this protein.

Published
2019

100. Using Coupled Models to Study the Effects of River Discharge on Biogeochemical Cycling and Hypoxia in the Northern Gulf of Mexico

Author

Penta, Bradley, Ko, D, Gould, Richard W, Arnone, Robert A, Greene, R, Lehrter, J, Hagy, James, Schaeffer, B, Murrell, M, Kurtz, J, Herchenroder, B, Green, R, and Eldridge, P

Subjects
Life Sciences (General)
Abstract

We describe emerging capabilities to understand physical processes and biogeoehemical cycles in coastal waters through the use of satellites, numerical models, and ship observations. Emerging capabilities provide significantly improved ability to model ecological systems and the impact of environmental management actions on them. The complex interaction of physical and biogeoehemical processes responsible for hypoxic events requires an integrated approach to research, monitoring, and modeling in order to fully define the processes leading to hypoxia. Our efforts characterizes the carbon cycle associated with river plumes and the export of organic matter and nutrients form coastal Louisiana wetlands and embayments in a spatially and temporally intensive manner previously not possible. Riverine nutrients clearly affect ecosystems in the northern Gulf of Mexico as evidenced in the occurrence of regional hypoxia events. Less known and largely unqualified is the export of organic matter and nutrients from the large areas of disappearing coastal wetlands and large embayments adjacent to the Louisiana Continental Shelf. This project provides new methods to track the river plume along the shelf and to estimate the rate of export of suspended inorganic and organic paniculate matter and dissolved organic matter form coastal habitats of south Louisiana.

Published
2009

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