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85 results on '"Kuroki, Lindsay M"'

52. Abstract 2429: Tumor and stromal AXL expression regulate ovarian cancer metastasis

Author

Mullen, Mary Margaret, primary, van Biljon, Lillian N., additional, Quinn, Jeanne, additional, Greenwade, Molly, additional, Opara, Gregory, additional, Noia, Hollie, additional, Hagemann, Ian S., additional, Hagemann, Andrea R., additional, Kuroki, Lindsay M., additional, McCourt, Carolyn K., additional, Thaker, Premal H., additional, Powell, Matthew A., additional, Mutch, David G., additional, Khabele, Dineo, additional, and Fuh, Katherine C., additional

Published
2022
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53. GAS6-AXL Inhibition by AVB-500 Overcomes Resistance to Paclitaxel in Endometrial Cancer by Decreasing Tumor Cell Glycolysis

Author

Bruce, Shaina F., primary, Cho, Kevin, additional, Noia, Hollie, additional, Lomonosova, Elena, additional, Stock, Elizabeth C., additional, Oplt, Alyssa, additional, Blachut, Barbara, additional, Mullen, Mary M., additional, Kuroki, Lindsay M., additional, Hagemann, Andrea R., additional, McCourt, Carolyn K., additional, Thaker, Premal H., additional, Khabele, Dineo, additional, Powell, Matthew A., additional, Mutch, David G., additional, Shriver, Leah P., additional, Patti, Gary J., additional, and Fuh, Katherine C., additional

Published
2022
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56. GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress

Author

Mullen, Mary M., primary, Lomonosova, Elena, additional, Toboni, Michael D., additional, Oplt, Alyssa, additional, Cybulla, Emily, additional, Blachut, Barbara, additional, Zhao, Peinan, additional, Noia, Hollie, additional, Wilke, Daniel, additional, Rankin, Erinn B., additional, Kuroki, Lindsay M., additional, Hagemann, Andrea R., additional, Hagemann, Ian S., additional, McCourt, Carolyn K., additional, Thaker, Premal H., additional, Mutch, David G., additional, Powell, Matthew A., additional, Mosammaparast, Nima, additional, Vindigni, Alessandro, additional, and Fuh, Katherine C., additional

Published
2022
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57. Inhibition of AXL and VEGF-A Has Improved Therapeutic Efficacy in Uterine Serous Cancer

Author

Toboni, Michael D., primary, Lomonosova, Elena, additional, Bruce, Shaina F., additional, Tankou, Jo’an I., additional, Mullen, Mary M., additional, Schab, Angela, additional, Oplt, Alyssa, additional, Noia, Hollie, additional, Wilke, Danny, additional, Kuroki, Lindsay M., additional, Hagemann, Andrea R., additional, McCourt, Carolyn K., additional, Thaker, Premal H., additional, Powell, Matthew A., additional, Khabele, Dineo, additional, Mutch, David G., additional, and Fuh, Katherine C., additional

Published
2021
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58. Text-message-based behavioral weight loss for endometrial cancer survivors with obesity: A randomized controlled trial

Author

Zamorano, Abigail S., primary, Wilson, Elise M., additional, Liu, Jingxia, additional, Leon, Andrea, additional, Kuroki, Lindsay M., additional, Thaker, Premal H., additional, McCourt, Carolyn K., additional, Fuh, Katherine C., additional, Powell, Matthew A., additional, Mutch, David G., additional, Evanoff, Bradley A., additional, Colditz, Graham A., additional, and Hagemann, Andrea R., additional

Published
2021
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61. The role of endometrial sampling for surveillance of recurrence in postmenopausal patients with medically inoperable stage I endometrial cancer

Author

Carey-Love, Angelina, primary, Mullen, Mary M., additional, Zamorano, Abigail, additional, Markovina, Stephanie, additional, Hagemann, Andrea R., additional, Fuh, Katherine C., additional, Thaker, Premal H., additional, Mutch, David G., additional, Powell, Matthew A., additional, and Kuroki, Lindsay M., additional

Published
2021
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65. Endometrial cancer: the move toward personalized cancer care

Author

Kuroki, Lindsay M. and Mutch, David G.

Subjects
Endometrial cancer, Cancer -- Care and treatment, Health
Abstract

Endometrial cancer is the most common malignancy of the female reproductive tract in the United States, and its incidence continues to rise, with an estimated 49,560 new cases predicted for [...]

Published
2013

67. Effect on response to neoadjuvant chemotherapy in high-grade serous ovarian cancer by inhibiting the GAS6/AXL pathway and inducing homologous recombination deficiency.

Author

Mullen, Mary M, primary, Lomonosova, Elena, additional, Toboni, Michael Driscoll, additional, Noia, Hollie M, additional, Wilke, Danny, additional, Oplt, Alyssa, additional, Guo, Lei, additional, Kuroki, Lindsay M, additional, Hagemann, Andrea R., additional, McCourt, Carolyn K, additional, Thaker, Premal H., additional, Mutch, David Gardner, additional, Powell, Matthew A., additional, and Fuh, Katherine Cynthia, additional

Published
2020
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68. Effect of inducing HR deficiency using AVB500, a receptor tyrosine kinase AXL inhibitor, on response to olaparib in uterine serous cancer.

Author

Toboni, Michael Driscoll, primary, Blachut, Barbara, additional, Mullen, Mary M, additional, Tankou, Jo'an, additional, Noia, Hollie M, additional, Oplt, Alyssa, additional, Wilke, Danny, additional, Kuroki, Lindsay M, additional, Hagemann, Andrea R., additional, McCourt, Carolyn K, additional, Thaker, Premal H., additional, Mutch, David Gardner, additional, Powell, Matthew A., additional, and Fuh, Katherine Cynthia, additional

Published
2020
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71. Inpatient management of hypercalcemia portends a poor prognosis among gynecologic oncology patients: A trigger to initiate hospice care?

Author

Cripe, James C., primary, Buchanan Jr, Tommy R., additional, Wan, Leping, additional, Hagemann, Andrea R., additional, McCourt, Carolyn K., additional, Massad, L. Stewart, additional, Fuh, Katherine C., additional, Mutch, David G., additional, Powell, Mathew A., additional, Thaker, Premal H., additional, and Kuroki, Lindsay M., additional

Published
2019
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72. Do gynecologic oncology patients with severely diminished renal function and urinary tract obstruction benefit from ureteral stenting or percutaneous nephrostomy?

Author

Liang, Brooke, primary, Lange, Sara S., additional, Massad, L. Stewart, additional, Dick, Rebecca, additional, Mills, Kathryn A., additional, Hagemann, Andrea R., additional, McCourt, Carolyn K., additional, Thaker, Premal H., additional, Fuh, Katherine C., additional, Mutch, David G., additional, Powell, Matthew A., additional, and Kuroki, Lindsay M., additional

Published
2019
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74. Adenovirus platform enhances transduction efficiency of human mesenchymal stem cells: An opportunity for cellular carriers of targeted TRAIL-based TR3 biologics in ovarian cancer

Author

Kuroki, Lindsay M., primary, Jin, Xingjian, additional, Dmitriev, Igor P., additional, Kashentseva, Elena A., additional, Powell, Matthew A., additional, Mutch, David G., additional, Dietz, Allan B., additional, Curiel, David T., additional, Hawkins, William G., additional, and Spitzer, Dirk, additional

Published
2017
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82. Trends in Cervical and Anal Cancer Incidence and Mortality in the United States.

Author

McKinnish TR, Kuroki LM, Schwarz JK, and Mazul AL

Abstract

Objectives: We describe trends in the incidence and mortality of cervical (CC) and anal (AC) cancers by race and neighborhood socioeconomic status., Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to construct a cohort of CC and AC cases from 2006 to 2018. Incidence rates and survival were calculated by race and neighborhood socioeconomic status (nSES). Annual percent change (APC) in incidence was calculated using linear regression, and 5-year overall survival (OS) by the Kaplan-Meier method., Results: Of the cases, 33,487 CC and 16,018 AC cases were identified. Women of low nSES were nearly 4 times more likely to be diagnosed with cervical cancer than those of high nSES. Cervical cancer incidence declined marginally in all groups except for low nSES women who are White (APC 0.0). Women who are Black had lower 5-year OS than their nSES counterparts of other races (most notably for Black women of low nSES 53% vs White 63%). Similarly, the low nSES AC cohort contained nearly 3 times the number of diagnoses as the high nSES cohort. AC incidence increased most in women who are White (APC 1.8 and 2.2 for low and high nSES) and men who are Black and low nSES (APC 3.3). Five-year OS was lowest for men who are Asian American and Pacific Islander (40% and 50% for low and high nSES, respectively)., Conclusions: These data suggest a strong correlation between nSES, race, and their interaction on the incidence and survival trends of HPV-related disease and highlight inconsistent effects between cervical and anal cancers., Competing Interests: Conflicts of interest: The authors have declared they have no conflicts of interest., (Copyright © 2024, ASCCP.)

Published
2024
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83. The role of endometrial sampling for surveillance of recurrence in postmenopausal patients with medically inoperable stage I endometrial cancer.

Author

Carey-Love A, Mullen MM, Zamorano A, Markovina S, Hagemann AR, Fuh KC, Thaker PH, Mutch DG, Powell MA, and Kuroki LM

Abstract

It is unclear if surveillance for postmenopausal women with medically inoperable stage 1 endometrial cancer (EC) should differ depending on their management strategy. Thus, we investigated the utility of surveillance endometrial sampling among 53 postmenopausal women with medically inoperable, clinical stage I, grade 1 endometrioid EC who received either progestin therapy or radiation between 2009 and 2018, at a single academic institution. Frequency and results of endometrial sampling, as well as recurrence and survival rates were studied. Of 53 patients, 18 (34.0%) received progestin therapy and 35 (66.0%) radiation. Medically managed patients were treated with megestrol acetate (27.7%), a levonorgestrel intrauterine device (27.7%), or both (44.4%). Radiated patients were mostly treated with high-dose rate brachytherapy only (77.1%). Surveillance endometrial sampling (median procedures = 4, range 1-10) was strictly adhered to among all patients who received progestin therapy, but infrequently (6/35, 17.1%) performed among radiated patients, yielding no positive results. Three recurrences occurred over the median follow-up of 38 months. Two (11%) women in the progestin therapy group recurred locally and were diagnosed by endometrial sampling. One (3%) patient in the radiation group recurred distally in the lung 25.3 months after completing brachytherapy. We conclude that appropriate surveillance for women with medically inoperable, clinical stage I, grade 1 EC depends on the management strategy. For those treated with progestins, surveillance with endometrial sampling every 3-6 months can reveal local recurrence. However, given the excellent local control after radiation, endometrial sampling may not be warranted for women treated with definitive radiation., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 The Authors.)

Published
2020
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84. Assessing Physician Adherence to Guidelines for Cervical Cancer Screening and Management of Abnormal Screening Results.

Author

Min CJ, Massad LS, Dick R, Powell MA, and Kuroki LM

Subjects
Adult, Aged, Cross-Sectional Studies, Early Detection of Cancer, Female, Gynecology, Humans, Middle Aged, Missouri, Obstetrics, Surveys and Questionnaires, Uterine Cervical Neoplasms pathology, Guideline Adherence statistics & numerical data, Physicians statistics & numerical data, Uterine Cervical Neoplasms diagnosis, Vaginal Smears statistics & numerical data
Abstract

Objective: The aim of the study was to survey obstetrician-gynecologists' cervical cancer screening practices and management of cervical abnormalities to ascertain adherence to guidelines., Methods: From January to July 2019, obstetrician-gynecologists at 5 St. Louis area hospitals were surveyed online about cervical cancer screening and management practices through 13 clinical vignettes. Survey scores and the American Society of Colposcopy and Cervical Pathology (ASCCP) app use were compared using Mann-Whitney tests., Results: When screening 30- to 65-year-old participants, 114 (98%) of the 116 total participants used co-testing, but only 71 (61%) screened at 5-year intervals. None used primary human papillomavirus (HPV) testing. For 21- to 29-year-old participants, 17 (15%) screened with annual cytology, whereas 14 (12%) used annual or every 3-year co-testing. Forty eight (41%) screened younger than 21 years, regardless of risk factors or only if immunocompromised. Eleven (9%) continued screening after total hysterectomy for benign indications. Only 2 (2%) responded to all clinical vignettes in adherence to guidelines. More than 30% of participants would pursue unnecessary HPV testing and/or loop electrosurgical excision procedure for persistent low-grade cytology. Fifty eight (48%) incorrectly reported hysterectomy as management for adenocarcinoma in situ on biopsy. Participants would undertreat young women with high-grade abnormalities including high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia 3 (48, 41%) and high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia 1 (65, 56%). Forty one (35%) reported exiting women from screening prematurely. The median score for participants using the ASCCP app was significantly greater than those who did not (79% vs 71%, p = .002)., Conclusions: Midwestern obstetrician-gynecologists' adherence to the guidelines for cervical cancer screening and management of abnormal results is suboptimal. Although co-testing for women aged 30-65 years has been broadly adopted, primary HPV testing has not. Physicians overscreen, overtreat low-grade lesions, and undertreat high-grade lesions in young women.

Published
2020
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85. Obesity counseling in obstetrics and gynecology: provider perceptions and barriers.

Author

Huepenbecker SP, Wan L, Leon A, Rosen D, Hoff J, Kuroki LM, Fuh KC, Powell MA, Mutch DG, Colditz GA, and Hagemann AR

Abstract

To determine how obstetricians and gynecologists (OB/GYNs) perceive the gynecologic health effects of obesity and to identify perceived obstacles to counseling. OB/GYNs with 3 St. Louis health systems were emailed a 46-question survey regarding physicians' role in counseling women on the health risks of obesity and barriers faced in achieving this counseling. Differences between respondents' gender, age, practice type, years in practice, and body mass index were assessed using Chi-square or Fisher's exact tests as appropriate. Of 318 OB/GYNs emailed, 134 completed surveys, including 82 generalists and 52 subspecialists. 93% of respondents believed it was necessary to educate patients on health risks of obesity. 90% and 75%, respectively, cited diagnoses of endometrial hyperplasia and cancer as teachable moments for counseling. The most frequently cited barriers to successful counseling were lack of time, referral services, and patient tools/information. Most did not believe they had adequate reimbursement (65%), training (53%) or educational resources (50%) to counsel patients. Survey answers differed by practice setting, gender, and provider age. Although most OB/GYN providers consider obesity counseling important, execution is hindered by perceived barriers that differ by provider gender, age, and practice type. For OB/GYNs, more effective weight management counseling will require better training and practice-specific strategies. Based on survey responses, better reimbursement combined with increased resources for appropriate referrals and cancer prevention counseling are needed in order to improve weight management implementation in OB/GYN. •The majority of OB/GYNs believe obesity counseling is important•Perceptions of obesity counseling differ based on provider/practice characteristics.•Lack of time, referral services, and patient tools are the biggest cited barriers to counseling.•Improved obesity counseling could improve downstream OB/GYN morbidities.

Published
2018
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