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571 results on '"Kuo, Min-Liang"'

51. N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity

Author

Hua, Kuo-Tai, Tan, Ching-Ting, Johansson, Gunnar, Lee, Jang-Ming, Yang, Pei-Wen, Lu, Hsin-Yi, Chen, Chi-Kuan, Su, Jen-Liang, Chen, PoShen B., Wu, Yu-Ling, Chi, Chia-Chun, Kao, Hsin-Jung, Shih, Hou-Jung, Chen, Min-Wei, Chien, Ming-Hsien, Chen, Pai-Sheng, Lee, Wei-Jiunn, Cheng, Tsu-Yao, Rosenberger, George, Chai, Chee-Yin, Yang, Chih-Jen, Huang, Ming-Shyan, Lai, Tsung-Ching, Chou, Teh-Ying, Hsiao, Michael, and Kuo, Min-Liang

Published
2011
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53. Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

Author

Kuo, Tsang-Chih, Tan, Ching-Ting, Chang, Yi-Wen, Hong, Chih-Chen, Lee, Wei-Jiunn, Chen, Min-Wei, Jeng, Yung-Ming, Chiou, Jean, Yu, Pei, Chen, Pai-Sheng, Wang, Ming-Yang, Hsiao, Michael, Su, Jen-Liang, and Kuo, Min-Liang

Subjects
Stem cells -- Health aspects -- Genetic aspects -- Research, Neovascularization -- Physiological aspects -- Genetic aspects -- Research, Lung cancer -- Development and progression -- Genetic aspects -- Research, Breast cancer -- Development and progression -- Genetic aspects -- Research, Health care industry
Abstract

Angiopoietin-like protein 1 (ANGPTL1) is a potent regulator of angiogenesis. Growing evidence suggests that ANGPTL family proteins not only target endothelial cells but also affect tumor cell behavior. In a [...]

Published
2013
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55. miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans

Author

Chen, Pai-Sheng, Su, Jen-Liang, Cha, Shih-Ting, Tarn, Woan-Yuh, Wang, Ming-Yang, Hsu, Hsing-Chih, Lin, Ming-Tsan, Chu, Chia-Yu, Hua, Kuo-Tai, Chen, Chiung-Nien, Kuo, Tsang-Chih, Chang, King-Jen, Hsiao, Michael, Chang, Yi-Wen, Chen, Jin-Shing, Yang, Pan-Chyr, and Kuo, Min-Liang

Subjects
Gene expression -- Physiological aspects, MicroRNA -- Properties, Cancer cells -- Genetic aspects, Genetic regulation -- Research, Breast cancer -- Development and progression, Health care industry
Abstract

MicroRNAs (miRNAs) influence many biological processes, including cancer. They do so by posttranscriptionally repressing target mRNAs to which they have sequence complementarity. Although it has been postulated that miRNAs can regulate other miRNAs, this has never been shown experimentally to our knowledge. Here, we demonstrate that miR-107 negatively regulates the tumor suppressor miRNA let-7 via a direct interaction. miR-107 was found to be highly expressed in malignant tissue from patients with advanced breast cancer, and its expression was inversely correlated with let-7 expression in tumors and in cancer cell lines. Ectopic expression of miR-107 in human cancer cell lines led to destabilization of mature let-7, increased expression of let-7 targets, and increased malignant phenotypes. In contrast, depletion of endogenous miR-107 dramatically increased the stability of mature let-7 and led to downregulation of let-7 targets. Accordingly, miR-107 expression increased the tumorigenic and metastatic potential of a human breast cancer cell line in mice via inhibition of let-7 and upregulation of let-7 targets. By mutating individual sites within miR-107 and let-7, we found that miR-107 directly interacts with let-7 and that the internal loop of the let-7/miR-107 duplex is critical for repression of let-7 expression. Altogether, we have identified an oncogenic role for miR-107 and provide evidence of a trans-regulational interaction among miRNAs in human cancer development., Introduction MicroRNAs (miRNAs) are involved in diverse biological processes including embryonic development, metabolism, viral infections, and human malignancies. These small noncoding RNAs belong to a novel class of gene regulators [...]

Published
2011
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56. The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1

Author

Pan, Szu-Hua, Chao, Yu-Chih, Hung, Pei-Fang, Chen, Hsuan-Yu, Yang, Shuenn-Chen, Chang, Yih-Leong, Wu, Chen-Tu, Chang, Cheng-Chi, Wang, Wen-Lung, Chan, Wing-Kai, Wu, Yi-Ying, Che, Ting-Fang, Wang, Lu-Kai, Lin, Chien-Yu, Lee, Yung-Chie, Kuo, Min-Liang, Lee, Chau-Hwang, Chen, Jeremy J.W., Hong, Tse-Ming, and Yang, Pan-Chyr

Subjects
Phosphoproteins -- Physiological aspects -- Research, Cancer -- Development and progression -- Research, Filopodia -- Physiological aspects -- Research, Health care industry
Abstract

Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if we are to develop new approaches to managing tumor metastasis. Tumor cell invasion of the local stroma is suppressed by collapsin response mediator protein-1 (CRMP-1). Recently, we identified a long isoform of CRMP-1 (LCRMP-1), expression of which correlates with cancer cell invasiveness and poor clinical outcome in patients with non-small-cell lung cancer (NSCLC). Here, we report that LCRMP-1 overexpression in noninvasive human cell lines enhanced filopodia formation, cancer cell migration, and invasion via stabilization of actin. This effect required a highly conserved N-terminal region of LCRMP-1 as well as the WASP family verprolin-homologous protein-1/actin nucleation pathway (WAVE-1/actin nucleation pathway). Furthermore, LCRMP-1 appeared to act downstream of Cdc42, a Rho family protein known to be involved in actin rearrangement. In addition, LCRMP-1 associated with CRMP-1, which downregulated cancer cell metastasis by interrupting the association of LCRMP-1 and WAVE-1. Finally, we found that high-level expression of LCRMP-1 and low-level expression of CRMP-1 were associated with lymph node metastasis and poor survival in patients with NSCLC. In sum, we show that LCRMP-1 and CRMP-1 have opposing functions in regulating cancer cell invasion and metastasis and propose that this pathway may serve as a potential anticancer target., Introduction Cancer metastasis, which is the major cause of treatment failure in cancer patients, is a complex process that involves basement membrane degradation, cell migration, stromal (local) invasion, angiogenesis, intravasation [...]

Published
2011
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60. Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

Author

Chen, Chi-Kuan, Yang, Ching-Yao, Hua, Kuo-Tai, Ho, Ming-Chih, Johansson, Gunnar, Jeng, Yung-Ming, Chen, Chiung-Nien, Chen, Min-Wei, Lee, Wei-Jiunn, Su, Jen-Liang, Lai, Tsung-Ching, Chou, Chi-Chi, Ho, Bing-Ching, Chang, Chuan-Fa, Lee, Po-Huang, Chang, King-Jen, Hsiao, Michael, Lin, Ming-Tsan, and Kuo, Min-Liang

Published
2014
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96. Editor's Note: MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis

Author

Cha, Shih-Ting, primary, Chen, Pai-Sheng, additional, Johansson, Gunnar, additional, Chu, Chia-Yu, additional, Wang, Ming-Yang, additional, Jeng, Yung-Ming, additional, Yu, Sung-Liang, additional, Chen, Jin-Shing, additional, Chang, King-Jen, additional, Jee, Shiou-Hwa, additional, Tan, Ching-Ting, additional, Lin, Ming-Tsan, additional, and Kuo, Min-Liang, additional

Published
2019
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