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This article presents a novel examination of a pivotal aspect of the creation of the Fundamental State Laws enacted on April 23, 1906, specifically addressing the question of the Emperor’s judicial powers. It is noted that previous iterations of the Fundamental State Laws (1832) did not delineate these powers, despite the acknowledgment of the judicial supremacy of monarchs in constitutional monarchies, particularly their right to grant pardons. The article analyzes different definitions of the Tsar’s judicial powers as outlined in three drafts of new Fundamental Laws prepared for Nicholas II in late 1905. Among these drafts, the proposal by P. A. Kharitonov emerged as the leading version. In both the draft from the State Chancellery and that of Professor O. O. Eikhelman, the judicial powers of the autocrat were framed similarly to those characteristic of constitutional monarchies at the beginning of the 20th century. In March 1906, the State Chancellery’s draft was reviewed by the Council of Ministers, chaired by Count S. Yu. Witte. With his support, conservative amendments were introduced to the draft — abolishing the nonremovability of judges established by the Judicial Statutes of 1864, preserving the Tsar’s direct involvement in administering justice, and affirming his right to dispense justice. It is demonstrated that during a Special Meeting in April 1906, liberal officials opposed these amendments, while Nicholas II sided with their critics. In the final version of the Fundamental Laws, the judicial powers of the Tsar largely conformed to European constitutionalism of the early 20th century.

Interventional oncology is a rapidly evolving field of cancer treatment. Minimally invasive techniques, such as transarterial embolization with chemotherapeutic and radioactive agents, are common treatments and are found in many guidelines for the treatment of primary and metastatic liver lesions. It is known that the growth and development of a malignant neoplasm is primarily determined by angiogenesis. Rapid growth is ensured where the formation is directly related to the arterial bed. Therefore, when the drug is injected into the target vessel and providing tissue ischemia, it is possible to achieve a high degree of tumor pathomorphosis. This technique has an advantage for patients who, in some cases, cannot be treated surgically, and also increases the effectiveness of the chemotherapeutic effect. With the advent of necessary equipment in hospitals and the accumulation of experience in the use of minimally invasive interventions, it became possible to implement a new method of treating tumors of various localizations. In this review, we consider the results of domestic and foreign authors on the topic of intra-arterial chemoembolization before surgical treatment in patients with rectal cancer. It is noted that the analysis of the literature revealed a small number of works devoted to the chosen topic, despite the relevance of this problem for modern oncology.

Objectives. Radio engineering information transmission systems are widely used in robotic systems employed in various military and civilian services. If such systems are used in a harsh environment, where a large amount of retransmitted interference occurs, for example, if a complex is buried under rubble or is located in reinforced concrete pipes or other utility facilities, communication with the command post may be lost. Thus, the task of maintaining reliable communications under difficult conditions of radio wave propagation is very urgent. In the field of telecommunications, multiposition types of modulation are widely used, which, despite their good spectral characteristics, provide low noise immunity under conditions of nonfluctuating interference, especially in cases of retransmitted interference. Therefore, it is relevant to explore the possibility of using multiple frequency-shift keying (M-FSK) signals in radio systems with complex interference environments. The paper sets out to analyze the noise immunity of coherent reception of M-FSK signals against the background of retransmitted interference.Methods. Statistical radio engineering and mathematical modeling methods are used according to the theory of optimal signal reception.Results. A model of the M-FSK signal and retransmitted interference is provided. The statistical parameters of the distributions of random processes occurring in a multichannel coherent receiver of M-FSK signals against retransmitted interference are obtained; based on this, the bit error rate is calculated when receiving M-FSK signals of different positionality M against retransmitted interference with different intensities.Conclusions. The impact of retransmitted interference is shown to result in a decrease in the noise immunity of M-FSK signal reception, which is greater the higher its intensity. With increasing positionality of M-FSK signals at low intensity of retransmitted interference, the noise immunity of reception is significantly improved; however, high-intensity interference significantly increases the bit error rate. The presence of interference with a relative intensity of 0.5 causes energy losses from 4 to 6 dB depending on the positionality. When M > 4, M-FSK signals gain significantly in terms of noise immunity over signals with multiple phase-shift keying, quadrature amplitude modulation, and amplitude and phase-shift keying.

This article addresses the artistic embodiment of the category of the Other in the works of American journalist and writer Tom Wolfe. The study focuses on Wolfe’s early journalistic essays, compiled in collections published in the early 1960s, as well as his later novel “I Am Charlotte Simmons” (2004). These texts are separated by nearly the entire second half of the 20th century — a period marked by the emergence, flourishing, and decline of postmodernism. The aim of this work is to trace the diachronic evolution of the author’s understanding of the category of the Other, as represented in his early and late texts. The desire for otherness among young people in the first post-war decades signified a fundamental rejection of norms, rules, and laws in the name of rejecting all forms of totalitarianism, which led to the catastrophic destruction of humanity during World War II. As a journalist, Wolfe objectively and empathetically depicts the diverse lifestyles of a new generation. He illustrates the consequences of these emerging trends in his university novel written forty years later. The article demonstrates that this work presents the otherness of various status groups within the university community through a multi-layered conflict. However, these groups remain isolated and hostile towards one another. The abandonment of rational consciousness has led to the primitivization of individuality and the disintegration of education. The novel serves as a vivid illustration of the negative outcomes of postmodernism.

The article examines the process of solving the problem of managing the foreign policy of the Russian Empire when creating the Fundamental State Laws on April 23, 1906. It emphasizes the importance of retaining control over international relations by the monarch and the Ministry of Foreign Affairs, effectively removing it from the influence of the State Duma. The perspectives of the authors of three drafts of the Fundamental Laws — P.A. Kharitonov, A.P. Salomon, and Count A.F. Heyden — are presented. While Kharitonov and Salomon permitted the involvement of the State Duma in the conclusion of international treaties, Heyden excluded such participation. In January-February 1906, Kharitonov’s draft was revised by senior officials of the State Chancellery under the leadership of Baron Yu.A. Ikskul von Hildenbandt and Count D.M. Solsky. It is shown that in the Chancellery’s draft, both the emperor and the State Duma remained involved in the conclusion of international treaties. This draft was discussed in March 1906 in Count S. Yu. Witte’s cabinet, and in the Council of Ministers’ version, despite an expert review by Professor F. F. Martens, popular representation was stripped of its right to participate in international treaty-making. The necessity for this was also justified by a draft of the Fundamental Laws prepared by Professor O.O. Eichelman. Attention is given to the Special Conference chaired by Nicholas II in April 1906, which consolidated the monarch’s monopoly over foreign policy within the Fundamental Laws. Nevertheless, the author argues that these same Fundamental Laws indirectly ensured the influence of the State Duma in this area, as without its review and approval, the budget of the Ministry of Foreign Affairs and all related legislative proposals could not be submitted for the emperor’s endorsement.

Searching for methods of treating primary rhegmatogenous retinal detachment (RRD) is a highly relevant issue, since this disease often leads to disability in people of young working age. The history of surgical treatment of retinal detachment began more than 200 years ago and has undergone many changes due to the evolution of knowledge of this disease. In the early 20th century, sealing of retinal breaks was first shown to be a key principle in the treatment of RRD. The two most commonly used surgical techniques today are pars plana vitrectomy and scleral buckling. Over the years, various materials have been studied as possible buckling means. At present, soft silicone fine-pored tape is the gold standard for scleral sealing. Modern laser technologies open up new vistas for extrascleral surgery in the treatment of primary RRD. The advantages of specific individual approaches or combinations thereof are under active discussion.

Glaucoma is one of the main causes of irreversible vision loss worldwide, its prevalence is increasing with age, reaching 10 % in individuals over 90 years old. Combined surgical treatment of cataract and glaucoma has proven to be safe and effective, reducing overall treatment costs. Minimally invasive glaucoma surgery (MIGS) combined with cataract surgery has become a popular alternative to traditional methods. One such intervention is endoscopic laser cyclodestruction (ELCD), aimed at reducing the production of aqueous humor.Objective: To evaluate the conditions for achieving maximum efficacy and safety of endoscopic laser cyclodestruction (ELCD) in the combined surgical treatment of glaucoma and cataract.Methods. A clinical study was conducted involving 110 patients (56 males and 54 females) with a mean age of 73.7 years, who underwent combined surgery (phacoemulsification + ELCD). Inclusion criteria were stages I-IV glaucoma and initial complicated cataract, while exclusion criteria included lens subluxation and presence of uveal processes or their consequences. ELCD was performed using the Endo Optiks Inc (USA) video-endoscopic ophthalmic laser device. Patients were evaluated preoperatively and followed up at 1, 3, 6, 9, 12, 18, 24, 36, 48, and 60 months postoperatively. The primary safety outcomes included the frequency of intraand postoperative complications, and efficacy outcomes were based on intraocular pressure (IOP) reduction.Results. No hemorrhagic complications were noted. An inflammatory reaction was observed in 18.2% cases, which was managed with subconjunctival injections of prourokinase. The frequency of postoperative IOP elevation correlated negatively with preoperative IOP levels. ELCD demonstrated a statistically significant reduction in IOP and medication burden, with a complete success rate of 52.7 % and a partial success rate of 90.3 %. The extent of cyclodestruction (180–360°) did not significantly affect IOP reduction outcomes.Conclusion. ELCD, performed as part of combined surgery for glaucoma and cataract, proved to be effective and safe, achieving significant IOP reduction and decreasing the need for antiglaucoma medications. Recommendations include avoiding vaporization effects during surgery and preferring patients with preoperative IOP above 27 mm Hg for optimal outcomes.

The article considers the strength issues of foundry cores manufactured by the Cold‑box‑amine process. It is shown that the properties of the core mix can be controlled by adjusting the formulation. Examples of the influence of binders’ consumption on the properties of the mixes are given: a decrease in resin and polyisocyanate leads to a decrease in strength and a decrease in life. In addition, the minimum consumption of binders varies from manufacturer to manufacturer. Recipes of mixes with special additives are given, which allow, by reducing the strength of the mix, to ensure the completeness of the polymerization reaction.

The intestinal barrier is one of the most important components that maintain gastrointestinal homeostasis, therefore changes in bacterial composition can lead to increased intestinal permeability and the development of intestinal translocation of opportunistic microorganisms, with the subsequent development or complication of various infectious diseases. A comparative description of the microbiota of the intestinal tract of calves with compensated, subcompensated and decompensated acute catarrhal bronchopneumonia of calves was carried out in the conditions of livestock farms of Vladimir and Moscow Oblasts. Calves aged 1–3 months with acute catarrhal bronchopneumonia (n = 37) were used for the study. The severity of the disease was assessed based on clinical and laboratory tests. The samples taken from clinically healthy animals (n = 8) were used as controls. It has been shown that in calves with compensated acute catarrhal bronchopneumonia, the qualitative and quantitative composition of the intestinal microbiome does not differ from clinically healthy animals. During the clinical manifestation of subcompensated and decompensated acute catarrhal bronchopneumonia in calves, a significant quantitative and qualitative shift in the microbiome occurs in the intestines, which indicates the occurrence of dysbiosis. We believe that this area is quite relevant and requires further scrupulous research.

Background. Acquired aplastic anemia (AA) is a non-tumor disease of the blood system and the pathogenesis is based on immune dysregulation directed against own hematopoietic stem cells, which leads to the development of bone marrow aplasia. Some modern research is directed to the study of intrinsic defects of hematopoietic stem cells, and one of which is the change in telomere length. Several large studies have shown the association of telomere shortening in AA patients with decreased overall survival, poor response to immunosuppressive therapy (IST), high rates of relapse and clonal complications.Aim. To study the influence of the initial telomeric DNA regions length in AA patients on the disease course.Materials and methods. 43 adult patients with acquired AA without previous pathogenetic therapy were included in the study. IST was performed according to a standard protocol including the use of hATG and cyclosporine. Flow-FISH was used as the method for measuring relative telomere length, and peripheral blood mononuclear cells were used as the study material.Results. Telomere length determined before IST did not differ between non-severe and severe AA, but there were significant differences depending on disease duration (p = 0.032). Initially short telomeres correlated with a lower rate of achieving hematologic improvement (53 % vs. 80 %; p = 0.059). In addition, significantly worse results were obtained in achieving partial and complete remission in patients with initially short telomeres compared to those with initially long telomeres (37 % vs. 62 % and 5 % vs. 23 %, respectively; p

Background. Aplastic anemia (AA) is a non-tumor and rare disease of the blood system, characterized by deep pancytopenia due to the development of bone marrow aplasia with immune-mediated damage of hematopoietic stem cells. Research results indicate the presence of antigenic effects leading to pathological activation and dysregulation of the T cells in the bone marrow with increased production of pro-inflammatory cytokines that damage hematopoietic stem cells. The triggering factor that initiates the cascade of immune reactions is currently unknown. The high efficiency of immunosuppressive therapy (IST), which allows achieving remission in the majority of AA patients, is evidence of the immune genesis of the disease. The pathogenesis of AA is currently being actively studied. The participation of T cell subpopulations in immune response is beyond doubt, but the issues of their significance in the AA pathogenesis have not been fully studied. A more detailed understanding of the AA development mechanisms is necessary for the development of long-term effective treatment.Aim. To investigate the T cells subpopulation in bone marrow of AA patients during IST.Materials and methods. The study included 41 patients over 18 years of age with newly diagnosed acquired AA without previous IST. Treatment was carried out according to a protocol including horse antithymocyte globulin and cyclosporine. Flow cytometry was used to detect T cell subpopulations. Bone marrow examination was performed at three time points: initially, 3 and 6 months after initiation of combined IST.Results. Multidirectional changes in the T cell subpopulations ratio before the start of IST were found in all AA patients included in the prospective study: most patients had a higher proportion of effector CD4+ and CD8+ T cells (61 and 83 % of patients, respectively), memory CD4+ T cells (63 % of patients), and a lower proportion of naive CD4+ and CD8+ T cells (81 and 51 % of patients, respectively) compared to donors (p

Background. Mycosis fungoides (MF) is classified as an orphan disease. Due to the rarity of pathology, and until recently the absence of an expert group and a specialized reference center for cutaneous lymphomas in Russia, possible treatment options for MF are presented by listing them without recommendations on the preferred indications for one or another option. This creates difficulties in choosing treatment methods and assessing their effectiveness.Aim. To characterize current treatment methods and their results in MF patients who were observed or received consultative and diagnostic care at the National Medical Research Center for Hematology.Materials and methods. The study included 210 patients: 115 with early disease stages and 95 with advanced stages.Results and conclusion. The most common treatment options were for early stages – local therapy, interferon therapy and systemic chemotherapy (CT), for advanced stages – combination therapy with interferon (+ PUVA therapy, methotrexate), interferon monotherapy and systemic CT. The frequency of systemic chemotherapy use in all lines of MF treatment was 21 %. When integrating statistical analysis using the probability of achieving an antitumor response, switching to 2nd line therapy, and accumulated incidence, the negative results of using chemotherapy in the MF treatment were clearly demonstrated.For the first time in Russia, a real practical situation of the applied MF treatment options is presented on our own large sample of patients. As the first line of therapy, the most common options were immunotherapy and phototherapy, however, in 12.4 % of cases, the use of systemic CT was registered, which is unjustified and leads to a decrease in the time to the next line of treatment and an increase in the cumulative incidence of adverse events. As a result of the use of non-chemotherapeutic approaches (interferon, etc.), the 3-year relapse-free survival rate is about 40 %, after chemotherapy – 9.4 %. Secondand third-line therapy provided more varied options, including combination treatment with interferon and methotrexate, as well as gemcitabine monotherapy, targeted therapy with brentuximab vedotin, and epigenetic therapy in the 3rd line. Studies with targeted agents in this patient population have demonstrated improved clinical outcomes, highlighting the need for their early use to achieve the best results.

​​​​​​​At the altitudes of the mesosphere–lower thermosphere, OH and HO2 play a significant role in many physicochemical processes. Thus, monitoring their spatiotemporal evolution, together with other chemically active trace gases, is one of the most important problems for this atmosphere region, in which direct measurements are difficult. This paper studies the nighttime OH and HO2 chemical equilibria using the 3D chemical transport modeling within the general approach, which includes the identification of the main sources and sinks in the equilibrium space–time areas and the derivation of analytical criteria for equilibrium validity. The presented analysis shows that there are extended areas where nighttime HO2 and OH are close to their local equilibrium concentrations, determined mainly by the reaction between HOx and Ox components among themselves and with H2O2, N, NO, NO2, and CO. In the upper mesosphere–lower thermosphere, the equilibrium expressions can be shortened so that they include the HOx–Ox chemistry only. These expressions describe the HO2 and OH equilibria from the top down to some boundaries, the altitude positions of which vary in the interval between 72–73 and 85 km and depend essentially on season and latitude. The developed analytical criteria reproduce the main features of these boundaries well almost everywhere. Due to weak sensitivity to uncertainties of reaction rates and other parameters, the criteria can be regarded as a robust instrument for HO2 and OH equilibrium validation. The obtained results allow us to extend previously proposed methods for the retrieval of poorly measured components from measurement data and to develop new approaches.