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52. Supplementary Figure 6 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs

Author

Freeman, Spencer A., primary, McLeod, Sarah J., primary, Dukowski, Janet, primary, Austin, Pamela, primary, Lee, Crystal C.Y., primary, Millen-Martin, Brandie, primary, Kubes, Paul, primary, McCafferty, Donna-Marie, primary, Gold, Michael R., primary, and Roskelley, Calvin D., primary

Published
2023
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53. Supplementary Figure Legends 1-6 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs

Author

Freeman, Spencer A., primary, McLeod, Sarah J., primary, Dukowski, Janet, primary, Austin, Pamela, primary, Lee, Crystal C.Y., primary, Millen-Martin, Brandie, primary, Kubes, Paul, primary, McCafferty, Donna-Marie, primary, Gold, Michael R., primary, and Roskelley, Calvin D., primary

Published
2023
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54. Supplementary Figure 3 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs

Author

Freeman, Spencer A., primary, McLeod, Sarah J., primary, Dukowski, Janet, primary, Austin, Pamela, primary, Lee, Crystal C.Y., primary, Millen-Martin, Brandie, primary, Kubes, Paul, primary, McCafferty, Donna-Marie, primary, Gold, Michael R., primary, and Roskelley, Calvin D., primary

Published
2023
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55. Supplementary Figure 1 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs

Author

Freeman, Spencer A., primary, McLeod, Sarah J., primary, Dukowski, Janet, primary, Austin, Pamela, primary, Lee, Crystal C.Y., primary, Millen-Martin, Brandie, primary, Kubes, Paul, primary, McCafferty, Donna-Marie, primary, Gold, Michael R., primary, and Roskelley, Calvin D., primary

Published
2023
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58. Supplementary Figure 4 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs

Author

Freeman, Spencer A., primary, McLeod, Sarah J., primary, Dukowski, Janet, primary, Austin, Pamela, primary, Lee, Crystal C.Y., primary, Millen-Martin, Brandie, primary, Kubes, Paul, primary, McCafferty, Donna-Marie, primary, Gold, Michael R., primary, and Roskelley, Calvin D., primary

Published
2023
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59. Supplementary Figure 5 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs

Author

Freeman, Spencer A., primary, McLeod, Sarah J., primary, Dukowski, Janet, primary, Austin, Pamela, primary, Lee, Crystal C.Y., primary, Millen-Martin, Brandie, primary, Kubes, Paul, primary, McCafferty, Donna-Marie, primary, Gold, Michael R., primary, and Roskelley, Calvin D., primary

Published
2023
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61. Supplementary Figure 2 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs

Author

Freeman, Spencer A., primary, McLeod, Sarah J., primary, Dukowski, Janet, primary, Austin, Pamela, primary, Lee, Crystal C.Y., primary, Millen-Martin, Brandie, primary, Kubes, Paul, primary, McCafferty, Donna-Marie, primary, Gold, Michael R., primary, and Roskelley, Calvin D., primary

Published
2023
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62. Hepatic C-X-C chemokine receptor type 6–expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury

Author

Heymann, Felix, primary, Mossanen, Jana C., additional, Peiseler, Moritz, additional, Niemietz, Patricia M., additional, Araujo David, Bruna, additional, Krenkel, Oliver, additional, Liepelt, Anke, additional, Batista Carneiro, Matheus, additional, Kohlhepp, Marlene S., additional, Kubes, Paul, additional, and Tacke, Frank, additional

Published
2023
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63. ICAMs are dispensable for influenza clearance and anti-viral humoral and cellular immunity

Author

Kozlovski, Stav, primary, Regev, Ofer, additional, Sapoznikov, Anita, additional, Kizner, Marina, additional, Achdout, Hagit, additional, Petrovich-Kopitman, Ekaterina, additional, Elkahal, Jacob, additional, Addadi, Yoseph, additional, Silva Castanheira, Fernanda Vargas E., additional, Feigelson, Sara W., additional, Kubes, Paul, additional, Erez, Noam, additional, Garbi, Natalio, additional, and Alon, Ronen, additional

Published
2023
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64. P-Selectin promotes SARS-CoV-2 interactions with platelets and the endothelium

Author

Moreno, Cesar L., primary, Castanheira, Fernanda V. S., additional, Stella, Alberto Ospina, additional, Chung, Felicity, additional, Aggarwal, Anupriya, additional, Cole, Alexander J., additional, Loo, Lipin, additional, Dupuy, Alexander, additional, Kong, Yvonne, additional, Hagimola, Lejla, additional, Fenwick, Jemma, additional, Coleman, Paul, additional, Willson, Michelle, additional, Bui-Marinos, Maxwell, additional, Hesselson, Daniel, additional, Gamble, Jennifer, additional, Passam, Freda, additional, Turville, Stuart, additional, Kubes, Paul, additional, and Neely, G. Gregory, additional

Published
2023
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66. PNAG exopolysaccharide eradication gives neutrophils access toStaphylococcus aureusbiofilm infections

Author

Kratofil, Rachel M., primary, Randall, Trevor E., additional, Hommes, Josefien W., additional, Sejuty, Rehnuma, additional, Chisholm, Jessica, additional, Raju, Deepa, additional, Vargas, Mario, additional, Howell, P. Lynne, additional, Pier, Gerald B., additional, Morck, Douglas W., additional, Harrison, Joe J., additional, and Kubes, Paul, additional

Published
2023
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70. Bispecific antibody targets multiple pseudomonas aeruginosa evasion mechanisms in the lung vasculature

Author

Thanabalasuriar, Ajitha, Surewaard, Bas G.J., Willson, Michelle E., Neupane, Arpan S., Stover, Charles K., Warrener, Paul, Wilson, George, Keller, Ashley E., Sellman, Bret R., DiGiandomenico, Antonio, and Kubes, Paul

Subjects
Antibodies -- Health aspects -- Analysis, Lung diseases -- Prevention, Pseudomonas aeruginosa -- Health aspects -- Analysis, Health care industry
Abstract

Pseudomonas aeruginosa is a major cause of severe infections that lead to bacteremia and high patient mortality. P. aeruginosa has evolved numerous evasion and subversion mechanisms that work in concert to overcome immune recognition and effector functions in hospitalized and immunosuppressed individuals. Here, we have used multilaser spinning-disk intravital microscopy to monitor the blood-borne stage in a murine bacteremic model of P. aeruginosa infection. P. aeruginosa adhered avidly to lung vasculature, where patrolling neutrophils and other immune cells were virtually blind to the pathogen's presence. This cloaking phenomenon was attributed to expression of Psl exopolysaccharide. Although an antiPsl mAb activated complement and enhanced neutrophil recognition of P. aeruginosa, neutrophil-mediated clearance of the pathogen was suboptimal owing to a second subversion mechanism, namely the type 3 secretion (T3S) injectisome. Indeed, T3S prevented phagosome acidification and resisted killing inside these compartments. Antibody-mediated inhibition of the T3S protein PcrV did not enhance bacterial phagocytosis but did enhance killing of the few bacteria ingested by neutrophils. A bispecific mAb targeting both Psl and PcrV enhanced neutrophil uptake of P. aeruginosa and also greatly increased inhibition of T3S function, allowing for phagosome acidification and bacterial killing. These data highlight the need to block multiple evasion and subversion mechanisms in tandem to kill P. aeruginosa., Introduction Pseudomonas aeruginosa is an important opportunistic bacterial pathogen that causes life-threatening infections in critically ill and immunocompromised individuals. It is one of the most common causes of Gram-negative pneumonia [...]

Published
2017
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71. An emerging role for neutrophil extracellular traps in noninfectious disease

Author

Jorch, Selina K and Kubes, Paul

Subjects
Chronic diseases -- Development and progression -- Care and treatment, Phagocytes -- Health aspects, Immune response -- Observations, Biological sciences, Health
Abstract

The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils to help catch and kill bacteria. However, increasing evidence suggests that this process might also occur in noninfectious, sterile inflammation. In this Review, we describe the role of NETosis in autoimmunity, coagulation, acute injuries and cancer, and discuss NETs as potential therapeutic targets. Furthermore, we consider whether extracellular DNA is always detrimental in sterile inflammation and whether the source is always NETs., Author(s): Selina K Jorch [1]; Paul Kubes (corresponding author) [1, 2] Neutrophil extracellular traps (NETs) are structures of chromatin filaments coated with histones, proteases and granular and cytosolic proteins, and [...]

Published
2017
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72. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

Author

Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles, and Ambati, Jayakrishna

Published
2014

77. Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial

Author

Kirkpatrick, Andrew W., Coccolini, Federico, Ansaloni, Luca, Roberts, Derek J., Tolonen, Matti, McKee, Jessica L., Leppaniemi, Ari, Faris, Peter, Doig, Christopher J., Catena, Fausto, Fabian, Timothy, Jenne, Craig N., Chiara, Osvaldo, Kubes, Paul, Manns, Braden, Kluger, Yoram, Fraga, Gustavo P., Pereira, Bruno M., Diaz, Jose J., Sugrue, Michael, Moore, Ernest E., Ren, Jianan, Ball, Chad G., Coimbra, Raul, Balogh, Zsolt J., Abu-Zidan, Fikri M., Dixon, Elijah, Biffl, Walter, MacLean, Anthony, Ball, Ian, Drover, John, McBeth, Paul B., Posadas-Calleja, Juan G., Parry, Neil G., Di Saverio, Salomone, Ordonez, Carlos A., Xiao, Jimmy, Sartelli, Massimo, and for The Closed Or Open after Laparotomy (COOL) after Source Control for Severe Complicated Intra-Abdominal Sepsis Investigators

Published
2018
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78. Getting the invite list right: a discussion of sepsis severity scoring systems in severe complicated intra-abdominal sepsis and randomized trial inclusion criteria

Author

Tolonen, Matti, Coccolini, Federico, Ansaloni, Luca, Sartelli, Massimo, Roberts, Derek J., McKee, Jessica L., Leppaniemi, Ari, Doig, Christopher J., Catena, Fausto, Fabian, Timothy, Jenne, Craig N., Chiara, Osvaldo, Kubes, Paul, Kluger, Yoram, Fraga, Gustavo P., Pereira, Bruno M., Diaz, Jose J., Sugrue, Michael, Moore, Ernest E., Ren, Jianan, Ball, Chad G., Coimbra, Raul, Dixon, Elijah, Biffl, Walter, MacLean, Anthony, McBeth, Paul B., Posadas-Calleja, Juan G., Di Saverio, Salomone, Xiao, Jimmy, Kirkpatrick, Andrew W., and From the Closed Or Open after Laparotomy (COOL) for Source Control in Severe Complicated Intra-Abdominal Sepsis Investigators

Published
2018
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85. Neutrophil phenotypes and functions in cancer: A consensus statement

Author

Quail, Daniela F., primary, Amulic, Borko, additional, Aziz, Monowar, additional, Barnes, Betsy J., additional, Eruslanov, Evgeniy, additional, Fridlender, Zvi G., additional, Goodridge, Helen S., additional, Granot, Zvi, additional, Hidalgo, Andrés, additional, Huttenlocher, Anna, additional, Kaplan, Mariana J., additional, Malanchi, Ilaria, additional, Merghoub, Taha, additional, Meylan, Etienne, additional, Mittal, Vivek, additional, Pittet, Mikael J., additional, Rubio-Ponce, Andrea, additional, Udalova, Irina A., additional, van den Berg, Timo K., additional, Wagner, Denisa D., additional, Wang, Ping, additional, Zychlinsky, Arturo, additional, de Visser, Karin E., additional, Egeblad, Mikala, additional, and Kubes, Paul, additional

Published
2022
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92. Neutrophils during SARS‐CoV‐2 infection: Friend or foe?

Author

Castanheira, Fernanda V. S. and Kubes, Paul

Subjects
*SARS-CoV-2, *CORONAVIRUS diseases, *COVID-19, *ADULT respiratory distress syndrome, *NEUTROPHILS
Abstract

Summary: Coronavirus disease 2019 (COVID‐19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has resulted in more than 6 million deaths worldwide. COVID‐19 is a respiratory disease characterized by pulmonary dysfunction leading to acute respiratory distress syndrome (ARDs), as well as disseminated coagulation, and multi‐organ dysfunction. Neutrophils and neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of COVID‐19. In this review, we highlight key gaps in knowledge, discuss the heterogeneity of neutrophils during the evolution of the disease, how they can contribute to COVID‐19 pathogenesis, and potential therapeutic strategies that target neutrophil‐mediated inflammatory responses. [ABSTRACT FROM AUTHOR]

Published
2023
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