18,248 results on '"Kron, A"'
Search Results
52. Association of tricuspid regurgitation with clinical events and quality of life after surgery for severe ischemic mitral regurgitation
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Strobel, Raymond J., Kramer, Benjamin P., Overbey, Jessica R., Mehaffey, J. Hunter, Hawkins, Robert B., II, Gammie, James S., Gillinov, Marc, Acker, Michael A., Kramer, Robert S., Smith, Peter K., Kron, Irving L., Voisine, Pierre, Taddei-Peters, Wendy C., Geller, Nancy L., Dagenais, François, Mack, Michael J., Moquete, Ellen G., Marks, Mary E., Iribarne, Alexander, Goldstein, Daniel J., Ailawadi, Gorav, O'Gara, Patrick T., Moskowitz, Alan J., Gelijns, Annetine C., and Bagiella, Emilia
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- 2024
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53. Review on high spatial resolution dosimetry with pixelated semiconductor detectors for radiation therapy
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Filipev, Ilia, Paino, Jason, Poder, Joel, Cutajar, Dean, Hardcastle, Nicholas, Guatelli, Susanna, Petasecca, Marco, Lerch, Michael, Feygelman, Vladimir, Kron, Tomas, and Rosenfeld, Anatoly
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- 2024
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54. Uncertainty estimation using a 3D probabilistic U-Net for segmentation with small radiotherapy clinical trial datasets
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Chlap, Phillip, Min, Hang, Dowling, Jason, Field, Matthew, Cloak, Kirrily, Leong, Trevor, Lee, Mark, Chu, Julie, Tan, Jennifer, Tran, Phillip, Kron, Tomas, Sidhom, Mark, Wiltshire, Kirsty, Keats, Sarah, Kneebone, Andrew, Haworth, Annette, Ebert, Martin A., Vinod, Shalini K., and Holloway, Lois
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- 2024
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55. Cost-Effectiveness of HIV Screening in Emergency Departments: Results From the Pragmatic Randomized HIV Testing Using Enhanced Screening Techniques in Emergency Departments Trial
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Austin, Bryan, Cohen, Jacob, Easley, Jackie, Haider, Somiya, Hill, Peter, Henley, Mauren, Kelen, Gabor, Leathers, Maggie, Maliszewski, Barbara, Neira, Paula, Newton, Scott, Peterson, Stephen, Saheed, Mustapha, Signer, Danielle, Spaeth, Lucas, Tolson, Tina, Toerper, Matthew, Viertel, Valentina, Whalen, Maddie, Ancona, Rachel, Cronin, Catherine, Fernandez, Frank, Fichtenbaum, Carl, Gaffney, Cortney, Hamilton, Cathy, Hart, Kim, Hoskins, Dave, Kohrs, Sharon, Lindsell, Christopher, Miller, Chris, Punches, Brittany, Ruffner, Andrew, Rowan, Geri, Vance, Kim, Williams, Teresa, Bucossi, Meggan, Cantrill, Steve, Chavez, Angelica, Comeau, Ann, Daugherty, Tracy, Delgado, Alex, Doyle, Pamela, Esquivel, Roberto, Fassino, Maren, Finnegan, Kelly, Fliney, Greg, Freudig, Theresa, Fuhriman, Michael, Gillman, Mary, Kahl-Geiger, Stacey, Keating, Korina, Koerner, Jason, Laber, Karen, Lang, Meghan, Lyle, Carolynn, Makela, Kim, Maltby, Mary, Medina, David, Nielsen, Tanya, Ortiz, Alice, Paolucci, Angela, Pate, Don, Pippins, Michael, Roy, Steven, Searcey, John, Solot, Jerry, Stermer, Kelly, Stuart, Brian, Swanson, Melissa, Timkovich, Lauren, Toure, Zenia, Vogel, Lisa, Walker, Sommer, Weed, Diane, Weise, Julia, Wenke, Kerri, Wham, Courtney, Wilson, Michael, Wright, Jarrod, Zwakenberg, Melody, Alter, Harrison, Anderson, Erik, Campbell, Brendan, Chang, Grace, Chao, Connie, Ellis, Katie, Graffman, Sarah, Kron, Brynn, Lucas, Rebecca, McCarthy, Caitlin, Ng, Valerie, O’Dell, Christine, Peck, Jim, Petti, Mae, Pfeil, Sarah, Saechao, Feuy, Simon, Barry, Todorovic, Tamara, Tyree, Tonya, Haukoos, Jason, Hopkins, Emily, Campbell, Jonathan D., Lyons, Michael S., Rothman, Richard E., Hsieh, Yu-Hsiang, White, Douglas A.E., Trent, Stacy, Al-Tayyib, Alia A., Gardner, Edward M., Sabel, Allison L., and Rowan, Sarah E.
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- 2024
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56. Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study
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Salmanton-García, Jon, Cornely, Oliver A., Stemler, Jannik, Barać, Aleksandra, Steinmann, Jörg, Siváková, Alena, Akalin, Emin Halis, Arikan-Akdagli, Sevtap, Loughlin, Laura, Toscano, Cristina, Narayanan, Manjusha, Rogers, Benedict, Willinger, Birgit, Akyol, Deniz, Roilides, Emmanuel, Lagrou, Katrien, Mikulska, Malgorzata, Denis, Blandine, Ponscarme, Diane, Scharmann, Urlike, Azap, Alpay, Lockhart, Deborah, Bicanic, Tihana, Kron, Florian, Erben, Nurettin, Rautemaa-Richardson, Riina, Goodman, Anna L., Garcia-Vidal, Carolina, Lass-Flörl, Cornelia, Gangneux, Jean-Pierre, Taramasso, Lucia, Ruiz, Maite, Schick, Yael, Van Wijngaerden, Eric, Milacek, Christopher, Giacobbe, Daniele Roberto, Logan, Clare, Rooney, Emily, Gori, Andrea, Akova, Murat, Bassetti, Matteo, Hoenigl, Martin, and Koehler, Philipp
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- 2024
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57. Adenosine 2A Receptor Agonism Improves Survival in Extracorporeal Cardiopulmonary Resuscitation
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Wisniewski, Alex M., Chancellor, William Z., Young, Andrew, Money, Dustin, Beller, Jared P., Charlton, Jennifer, Lunardi, Nadia, Yang, Zequan, Laubach, Victor E., Mehaffey, J. Hunter, Kron, Irving L., and Roeser, Mark E.
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- 2024
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58. Targeted Antioxidant Therapy Reduces Hyperglycemic Exacerbation of Myocardial Ischemia/Reperfusion Injury
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Rastogi, Radhika, Marsh, Katherine, Zhang, Aimee Y., Wu, Di, Chordia, Mahendra D., Pan, Dongfeng, Kron, Irving L., and Yang, Zequan
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- 2024
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59. On the transcreation, format and actionability of healthcare translations
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Sengupta, Medha, Pym, Anthony, Hao, Yu, Hajek, John, Karidakis, Maria, Woodward-Kron, Robyn, and Amorati, Riccardo
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- 2024
60. The demand-what-you-want strategy to service recovery: achieving high customer satisfaction with low service failure compensation using anchoring and precision effects
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Kron, Nathalie, Björkman, Jesper, Ek, Peter, Pihlgren, Micael, Mazraeh, Hanan, Berggren, Benny, and Sörqvist, Patrik
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- 2023
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61. The relation between learners’ experience in simulations and diagnostic accuracy: Generalizability across medical and teacher education
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Olga Chernikova, Matthias Stadler, Daniel Sommerhoff, Christian Schons, Nicole Heitzmann, Doris Holzberger, Tina Seidel, Constanze Richters, Amadeus J. Pickal, Christof Wecker, Michael Nickl, Elias Codreanu, Stefan Ufer, Stephanie Kron, Caroline Corves, Birgit J. Neuhaus, Martin R. Fischer, and Frank Fischer
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Simulation-based learning ,Diagnostic skills ,Learners' experience ,Higher education ,Cross-domain research ,Electronic computers. Computer science ,QA75.5-76.95 ,Psychology ,BF1-990 - Abstract
Simulation-based learning is being increasingly implemented across different domains of higher education to facilitate essential skills and competences (e.g. diagnostic skills, problem-solving, etc.). However, the lack of research that assesses and compares simulations used in different contexts (e.g., from design perspective) makes it challenging to effectively transfer good practices or establish guidelines for effective simulations across different domains. This study suggests some initial steps to address this issue by investigating the relations between learners' experience in simulation-based learning environments and learners' diagnostic accuracy across several different domains and types of simulations, with the goal of facilitating cross-domain research and generalizability. The findings demonstrate that used learners' experience ratings are correlated with objective performance measures, and can be used for meaningful comparisons across different domains. Measures of perceived extraneous cognitive load were found to be specific to the simulation and situation, while perceived involvement and authenticity were not. Further, the negative correlation between perceived extraneous cognitive load and perceived authenticity was more pronounced in interaction-based simulations. These results provide supporting evidence for theoretical models that highlight the connection between learners' experience in simulated learning environments and their performance. Overall, this research contributes to the understanding of the relationship between learners’ experience in simulation-based learning environments and their diagnostic accuracy, paving the way for the dissemination of best practices across different domains within higher education.
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- 2024
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62. Conclusions
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Kairn, Tanya, primary, Crowe, Scott B, additional, and Kron, Tomas, additional
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- 2023
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63. Introduction
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Kairn, Tanya, primary and Kron, Tomas, additional
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- 2023
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64. Dwarf AGNs from Optical Variability for the Origins of Seeds (DAVOS): Insights from the Dark Energy Survey Deep Fields
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Burke, Colin J., Liu, Xin, Shen, Yue, Phadke, Kedar A., Yang, Qian, Hartley, Will G., Harrison, Ian, Palmese, Antonella, Guo, Hengxiao, Zhang, Kaiwen, Kron, Richard, Turner, David J., Giles, Paul A., Lidman, Christopher, Chen, Yu-Ching, Gruendl, Robert A., Choi, Ami, Amon, Alexandra, Sheldon, Erin, Aguena, M., Allam, S., Andrade-Oliveira, F., Bacon, D., Bertin, E., Brooks, D., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Conselice, C., Costanzi, M., da Costa, L. N., Pereira, M. E. S., Davis, T. M., De Vicente, J., Desai, S., Diehl, H. T., Everett, S., Ferrero, I., Flaugher, B., García-Bellido, J., Gaztanaga, E., Gruen, D., Gschwend, J., Gutierrez, G., Hinton, S. R., Hollowood, D. L., Honscheid, K., Hoyle, B., James, D. J., Kuehn, K., Maia, M. A. G., Marshall, J. L., Menanteau, F., Miquel, R., Morgan, R., Paz-Chinchón, F., Pieres, A., Malagón, A. A. Plazas, Reil, K., Romer, A. K., Sanchez, E., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Smith, M., Suchyta, E., Tarle, G., Thomas, D., To, C., Varga, T. N., Wilkinson, R. D., and Collaboration, DES
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present a sample of 706, $z < 1.5$ active galactic nuclei (AGNs) selected from optical photometric variability in three of the Dark Energy Survey (DES) deep fields (E2, C3, and X3) over an area of 4.64 deg$^2$. We construct light curves using difference imaging aperture photometry for resolved sources and non-difference imaging PSF photometry for unresolved sources, respectively, and characterize the variability significance. Our DES light curves have a mean cadence of 7 days, a 6 year baseline, and a single-epoch imaging depth of up to $g \sim 24.5$. Using spectral energy distribution (SED) fitting, we find 26 out of total 706 variable galaxies are consistent with dwarf galaxies with a reliable stellar mass estimate ($M_{\ast}<10^{9.5}\ M_\odot$; median photometric redshift of 0.9). We were able to constrain rapid characteristic variability timescales ($\sim$ weeks) using the DES light curves in 15 dwarf AGN candidates (a subset of our variable AGN candidates) at a median photometric redshift of 0.4. This rapid variability is consistent with their low black hole masses. We confirm the low-mass AGN nature of one source with a high S/N optical spectrum. We publish our catalog, optical light curves, and supplementary data, such as X-ray properties and optical spectra, when available. We measure a variable AGN fraction versus stellar mass and compare to results from a forward model. This work demonstrates the feasibility of optical variability to identify AGNs with lower black hole masses in deep fields, which may be more "pristine" analogs of supermassive black hole seeds., Comment: 21 pages, 22 figures incl. 3 appendices; accepted for publication in MNRAS
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- 2021
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65. Special Educator Knowledge and Perspectives about Inclusive Postsecondary Education Programs
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Bumble, Jennifer L., Rooney-Kron, Magen, Gilson, Carly B., Sanderson, Kelli A., and Regester, April
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Special education teachers play an integral role in preparing students with intellectual and developmental disabilities (IDD) for a successful transition to their desired postsecondary pathways. As more opportunities arise for students with IDD to attend inclusive postsecondary education (IPSE) programs, there is a growing need for special educators to be well-prepared to equip their students for college. We conducted a survey of 1,086 secondary special education teachers in three states to better understand their knowledge, expectations, and perspectives regarding postsecondary options for students with IDD. We also examined the educator- and school-level factors associated with students with IDD having postsecondary goals for college in their Individualized Education Program (IEP). We describe special educator preferences for learning about college options for their students with IDD and practical implications for special educators, teacher preparation programs, and IPSE programs.
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- 2023
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66. Effects of the application of microbiologically activated bio-based fertilizers derived from manures on tomato plants and their rhizospheric communities
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Elisa Clagnan, Mirko Cucina, Patrizia De Nisi, Marta Dell’Orto, Giuliana D’Imporzano, Roberto Kron-Morelli, Laia Llenas-Argelaguet, and Fabrizio Adani
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Medicine ,Science - Abstract
Abstract Bio-based fertilizers (BBFs) recovered from animal manure are promising products to optimise resources recovery and generate high agricultural yields. However, their fertilization value may be limited and it is necessary to enrich BBFs with microbial consortia to enhance their fertilization value. Three specific microbial consortia were developed according to the characteristics of three different BBFs produced from manure (bio-dried solid fraction, solid fraction of digestate and biochar) to enhance plant growth and product quality. A greenhouse pot experiment was carried out with tomato plants grown with microbiologically activated BBFs applied either as N-organic fertilizers or as an organic amendment. A next generation sequencing analysis was used to characterise the development of each rhizospheric community. All the activated BBFs gave enhanced tomato yields (fresh and dry weight) compared with the non-activated treatments and similar to, or higher than, chemical fertilization. Concerning the tomato fruits’ organoleptic quality, lycopene and carotenoids concentrations were improved by biological activation. Metagenomic analysis points at Trichoderma as the main driver of the positive effects, with the effects of added bacteria being negligible or limited at the early stages after fertilization. In the context of the circular economy, the activated BBFs could be used to replace synthetic fertilisers, reducing costs and environmental burdens and increasing production.
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- 2023
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67. Life-Threatening Arrhythmias in Patients With Takotsubo Syndrome: Insights Into Pathophysiology and Treatment Innovations
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La Vecchia, Giulia, Del Buono, Marco Giuseppe, Sanna, Tommaso, Capecchi, Pier Leopoldo, Lazzerini, Pietro Enea, Golino, Michele, Kron, Jordana, Rodriguez-Miguelez, Paula, Pelargonio, Gemma, and Abbate, Antonio
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- 2024
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68. Indirect comparison of capmatinib treatment from GEOMETRY mono-1 trial to SOC in German patients with locally advanced or metastatic NSCLC harboring METex14 skipping mutations
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Kron, Anna, Scheffler, Matthias, Wiesweg, Marcel, Hummel, Horst-Dieter, Kulhavy, Jonas, Gatteloehner, Stefan, Kollmeier, Jens, Schubart, Christoph, Groß, Thorben, Demes, Melanie-Christin, Keymel, Stefanie, Joosten, Maria, Merkelbach-Bruse, Sabine, Wölwer, Christina Bianca, Tufman, Amanda, Kauffmann-Guerrero, Diego, Oeser, Katharina, Zehaczek, Melanie, Jeratsch, Ulli, and Wolf, Juergen
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- 2024
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69. “I'm on an island”: A qualitative study of underperforming surgical trainee perspectives on remediation
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McLeod, Kathryn, Woodward-Kron, Robyn, Rashid, Prem, Archer, Julian, and Nestel, Debra
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- 2024
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70. Der Weg zum Leberkrebszentrum: Versorgungs- und Patientenpfadanalyse für Patientinnen und Patienten mit hepatozellulärem Karzinom
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Waldschmidt, D., Kron, F., Eilers, L., Osterkamp, V., Wiebner, B., Goeser, T., Bruns, C., Stippel, D., Wedemeyer, H., and Wahba, R.
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- 2023
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71. Dark Energy Survey Year 3 Results: Cosmological Constraints from Galaxy Clustering and Weak Lensing
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DES Collaboration, Abbott, T. M. C., Aguena, M., Alarcon, A., Allam, S., Alves, O., Amon, A., Andrade-Oliveira, F., Annis, J., Avila, S., Bacon, D., Baxter, E., Bechtol, K., Becker, M. R., Bernstein, G. M., Bhargava, S., Birrer, S., Blazek, J., Brandao-Souza, A., Bridle, S. L., Brooks, D., Buckley-Geer, E., Burke, D. L., Camacho, H., Campos, A., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Castander, F. J., Cawthon, R., Chang, C., Chen, A., Chen, R., Choi, A., Conselice, C., Cordero, J., Costanzi, M., Crocce, M., da Costa, L. N., Pereira, M. E. da Silva, Davis, C., Davis, T. M., De Vicente, J., DeRose, J., Desai, S., Di Valentino, E., Diehl, H. T., Dietrich, J. P., Dodelson, S., Doel, P., Doux, C., Drlica-Wagner, A., Eckert, K., Eifler, T. F., Elsner, F., Elvin-Poole, J., Everett, S., Evrard, A. E., Fang, X., Farahi, A., Fernandez, E., Ferrero, I., Ferté, A., Fosalba, P., Friedrich, O., Frieman, J., García-Bellido, J., Gatti, M., Gaztanaga, E., Gerdes, D. W., Giannantonio, T., Giannini, G., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Harrison, I., Hartley, W. G., Herner, K., Hinton, S. R., Hollowood, D. L., Honscheid, K., Hoyle, B., Huff, E. M., Huterer, D., Jain, B., James, D. J., Jarvis, M., Jeffrey, N., Jeltema, T., Kovacs, A., Krause, E., Kron, R., Kuehn, K., Kuropatkin, N., Lahav, O., Leget, P. -F., Lemos, P., Liddle, A. R., Lidman, C., Lima, M., Lin, H., MacCrann, N., Maia, M. A. G., Marshall, J. L., Martini, P., McCullough, J., Melchior, P., Mena-Fernández, J., Menanteau, F., Miquel, R., Mohr, J. J., Morgan, R., Muir, J., Myles, J., Nadathur, S., Navarro-Alsina, A., Nichol, R. C., Ogando, R. L. C., Omori, Y., Palmese, A., Pandey, S., Park, Y., Paz-Chinchón, F., Petravick, D., Pieres, A., Malagón, A. A. Plazas, Porredon, A., Prat, J., Raveri, M., Rodriguez-Monroy, M., Rollins, R. P., Romer, A. K., Roodman, A., Rosenfeld, R., Ross, A. J., Rykoff, E. S., Samuroff, S., Sánchez, C., Sanchez, E., Sanchez, J., Cid, D. Sanchez, Scarpine, V., Schubnell, M., Scolnic, D., Secco, L. F., Serrano, S., Sevilla-Noarbe, I., Sheldon, E., Shin, T., Smith, M., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tabbutt, M., Tarle, G., Thomas, D., To, C., Troja, A., Troxel, M. A., Tucker, D. L., Tutusaus, I., Varga, T. N., Walker, A. R., Weaverdyck, N., Wechsler, R., Weller, J., Yanny, B., Yin, B., Zhang, Y., and Zuntz, J.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the first cosmology results from large-scale structure in the Dark Energy Survey (DES) spanning 5000 deg$^2$. We perform an analysis combining three two-point correlation functions (3$\times$2pt): (i) cosmic shear using 100 million source galaxies, (ii) galaxy clustering, and (iii) the cross-correlation of source galaxy shear with lens galaxy positions. The analysis was designed to mitigate confirmation or observer bias; we describe specific changes made to the lens galaxy sample following unblinding of the results. We model the data within the flat $\Lambda$CDM and $w$CDM cosmological models. We find consistent cosmological results between the three two-point correlation functions; their combination yields clustering amplitude $S_8=0.776^{+0.017}_{-0.017}$ and matter density $\Omega_{\mathrm{m}} = 0.339^{+0.032}_{-0.031}$ in $\Lambda$CDM, mean with 68% confidence limits; $S_8=0.775^{+0.026}_{-0.024}$, $\Omega_{\mathrm{m}} = 0.352^{+0.035}_{-0.041}$, and dark energy equation-of-state parameter $w=-0.98^{+0.32}_{-0.20}$ in $w$CDM. This combination of DES data is consistent with the prediction of the model favored by the Planck 2018 cosmic microwave background (CMB) primary anisotropy data, which is quantified with a probability-to-exceed $p=0.13$ to $0.48$. When combining DES 3$\times$2pt data with available baryon acoustic oscillation, redshift-space distortion, and type Ia supernovae data, we find $p=0.34$. Combining all of these data sets with Planck CMB lensing yields joint parameter constraints of $S_8 = 0.812^{+0.008}_{-0.008}$, $\Omega_{\mathrm{m}} = 0.306^{+0.004}_{-0.005}$, $h=0.680^{+0.004}_{-0.003}$, and $\sum m_{\nu}<0.13 \;\mathrm{eV\; (95\% \;CL)}$ in $\Lambda$CDM; $S_8 = 0.812^{+0.008}_{-0.008}$, $\Omega_{\mathrm{m}} = 0.302^{+0.006}_{-0.006}$, $h=0.687^{+0.006}_{-0.007}$, and $w=-1.031^{+0.030}_{-0.027}$ in $w$CDM. (abridged), Comment: See https://www.darkenergysurvey.org/des-year-3-cosmology-results-papers/ for the full DES Y3 3x2pt cosmology release. Matches version accepted in PRD
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- 2021
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72. Dark Energy Survey Year 3 Results: Cosmology from Cosmic Shear and Robustness to Data Calibration
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Amon, A., Gruen, D., Troxel, M. A., MacCrann, N., Dodelson, S., Choi, A., Doux, C., Secco, L. F., Samuroff, S., Krause, E., Cordero, J., Myles, J., DeRose, J., Wechsler, R. H., Gatti, M., Navarro-Alsina, A., Bernstein, G. M., Jain, B., Blazek, J., Alarcon, A., Ferté, A., Raveri, M., Lemos, P., Campos, A., Prat, J., Sánchez, C., Jarvis, M., Alves, O., Andrade-Oliveira, F., Baxter, E., Bechtol, K., Becker, M. R., Bridle, S. L., Camacho, H., Rosell, A. Carnero, Kind, M. Carrasco, Cawthon, R., Chang, C., Chen, R., Chintalapati, P., Crocce, M., Davis, C., Diehl, H. T., Drlica-Wagner, A., Eckert, K., Eifler, T. F., Elvin-Poole, J., Everett, S., Fang, X., Fosalba, P., Friedrich, O., Giannini, G., Gruendl, R. A., Harrison, I., Hartley, W. G., Herner, K., Huang, H., Huff, E. M., Huterer, D., Kuropatkin, N., Leget, P. -F., Liddle, A. R., McCullough, J., Muir, J., Pandey, S., Park, Y., Porredon, A., Refregier, A., Rollins, R. P., Roodman, A., Rosenfeld, R., Ross, A. J., Rykoff, E. S., Sanchez, J., Sevilla-Noarbe, I., Sheldon, E., Shin, T., Troja, A., Tutusaus, I., Varga, T. N., Weaverdyck, N., Yanny, B., Yin, B., Zhang, Y., Zuntz, J., Aguena, M., Allam, S., Annis, J., Bacon, D., Bertin, E., Bhargava, S., Brooks, D., Buckley-Geer, E., Burke, D. L., Carretero, J., Costanzi, M., da Costa, L. N., Pereira, M. E. S., De Vicente, J., Desai, S., Dietrich, J. P., Doel, P., Ferrero, I., Flaugher, B., Frieman, J., García-Bellido, J., Gaztanaga, E., Gerdes, D. W., Giannantonio, T., Gschwend, J., Gutierrez, G., Hinton, S. R., Hollowood, D. L., Honscheid, K., Hoyle, B., James, D. J., Kron, R., Kuehn, K., Lahav, O., Lima, M., Lin, H., Maia, M. A. G., Marshall, J. L., Martini, P., Melchior, P., Menanteau, F., Miquel, R., Mohr, J. J., Morgan, R., Ogando, R. L. C., Palmese, A., Paz-Chinchón, F., Petravick, D., Pieres, A., Malagón, A. A. Plazas, Romer, A. K., Sanchez, E., Scarpine, V., Schubnell, M., Serrano, S., Smith, M., Soares-Santos, M., Suchyta, E., Tarle, G., Thomas, D., To, C., and Weller, J.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
This work, together with its companion paper, Secco and Samuroff et al. (2021), presents the Dark Energy Survey Year 3 cosmic shear measurements and cosmological constraints based on an analysis of over 100 million source galaxies. With the data spanning 4143 deg$^2$ on the sky, divided into four redshift bins, we produce the highest significance measurement of cosmic shear to date, with a signal-to-noise of 40. We conduct a blind analysis in the context of the $\Lambda$CDM model and find a 3% constraint of the clustering amplitude, $S_8\equiv \sigma_8 (\Omega_{\rm m}/0.3)^{0.5} = 0.759^{+0.025}_{-0.023}$. A $\Lambda$CDM-Optimized analysis, which safely includes smaller scale information, yields a 2% precision measurement of $S_8= 0.772^{+0.018}_{-0.017}$ that is consistent with the fiducial case. The two low-redshift measurements are statistically consistent with the Planck Cosmic Microwave Background result, however, both recovered $S_8$ values are lower than the high-redshift prediction by $2.3\sigma$ and $2.1\sigma$ ($p$-values of 0.02 and 0.05), respectively. The measurements are shown to be internally consistent across redshift bins, angular scales and correlation functions. The analysis is demonstrated to be robust to calibration systematics, with the $S_8$ posterior consistent when varying the choice of redshift calibration sample, the modeling of redshift uncertainty and methodology. Similarly, we find that the corrections included to account for the blending of galaxies shifts our best-fit $S_8$ by $0.5\sigma$ without incurring a substantial increase in uncertainty. We examine the limiting factors for the precision of the cosmological constraints and find observational systematics to be subdominant to the modeling of astrophysics. Specifically, we identify the uncertainties in modeling baryonic effects and intrinsic alignments as the limiting systematics., Comment: 42 pages, 19 figures
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- 2021
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73. OzDES Reverberation Mapping Program: The first Mg II lags from five years of monitoring
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Yu, Zhefu, Martini, Paul, Penton, A., Davis, T. M., Malik, U., Lidman, C., Tucker, B. E., Sharp, R., Kochanek, C. S., Peterson, B. M., Aguena, M., Allam, S., Andrade-Oliveira, F., Annis, J., Asorey, J., Bertin, E., Brooks, D., Burke, D. L., Calcino, J., Rosell, A. Carnero, Carollo, D., Kind, M. Carrasco, Costanzi, M., da Costa, L. N., Pereira, M. E. S., Diehl, H. T., Everett, S., Ferrero, I., Flaugher, B., Frieman, J., García-Bellido, J., Gaztanaga, E., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hinton, S. R., Hollowood, D. L., James, D. J., Kim, A. G., Kron, R., Kuehn, K., Kuropatkin, N., Lewis, G. F., Maia, M. A. G., March, M., Marshall, J. L., Menanteau, F., Miquel, R., Morgan, R., Möller, A., Palmese, A., Paz-Chinchón, F., Plazas, A. A., Sanchez, E., Scarpine, V., Serrano, S., Sevilla-Noarbe, I., Smith, M., Soares-Santos, M., Suchyta, E., Tarle, G., Thomas, D., To, C., and Tucker, D. L.
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Astrophysics - Astrophysics of Galaxies - Abstract
Reverberation mapping is a robust method to measure the masses of supermassive black holes (SMBHs) outside of the local Universe. Measurements of the radius -- luminosity ($R-L$) relation using the Mg II emission line are critical for determining these masses near the peak of quasar activity at $z \approx 1 - 2$, and for calibrating secondary mass estimators based on Mg II that can be applied to large samples with only single-epoch spectroscopy. We present the first nine Mg II lags from our five-year Australian Dark Energy Survey (OzDES) reverberation mapping program, which substantially improves the number and quality of Mg II lag measurements. As the Mg II feature is somewhat blended with iron emission, we model and subtract both the continuum and iron contamination from the multi-epoch spectra before analyzing the Mg II line. We also develop a new method of quantifying correlated spectroscopic calibration errors based on our numerous, contemporaneous observations of F-stars. The lag measurements for seven of our nine sources are consistent with both the H$\beta$ and Mg II $R-L$ relations reported by previous studies. Our simulations verify the lag reliability of our nine measurements, and we estimate that the median false positive rate of the lag measurements is $4\%$., Comment: 18 pages, 12 figures. MNRAS, Volume 507, Issue 3, November 2021, Pages 3771-3788
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- 2021
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74. Systematic Review of Interventions for Teaching Individuals with Severe Disabilities Workplace Social Skills
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Birri, Nicole L., Dymond, Stacy K., and Rooney-Kron, Magen
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- 2022
75. You can't study medicine part time, can you?
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Scarff, C E, Cheshire, L, and Woodward-Kron, R
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- 2023
76. The Influence of Different Polyphenols on the Digestibility of Various Kinds of Starch and the Value of the Estimated Glycemic Index
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Dominika Kwaśny, Barbara Borczak, Joanna Kapusta-Duch, and Ivan Kron
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starch digestibility ,polyphenol ,glycemic index ,inhibitory activity ,molecular structure ,epigallocatechin gallate ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Considering the prevalence of diet-related diseases, new ways of preventing them are being sought. One of them is the addition of polyphenols to high-starch products to inhibit their digestibility and reduce their glycemic index. Therefore, this study aimed to investigate the differences between polyphenols popular in food ((+)catechin, epigallocatechin gallate, quercetin, kaempferol, naringenin, hesperidin, trans-ferulic acid, and p-coumaric acid), in terms of their impact on wheat, rice, potato, and maize starch digestibility. Polyphenols were added to starch separately, before and after its pasting, in one of the following doses: 5, 10, and 20 mg. Starch was digested in the presence of single polyphenols to measure RDS (rapidly digestible starch), SDS (slowly digestible starch), RS (resistant starch), and TS (total starch) content. On that basis, the SDI (starch digestion index) was calculated, and the GI (glycemic index) was estimated. The results show that polyphenols inhibit starch digestion at different levels depending on the type of tested starch and the time of polyphenol addition. However, in terms of RDS, TS, and eGI (estimated glycemic index), the greatest impact was observed for epigallocatechin gallate in a dose of 20 mg most frequently, independently of the kind of tested starch and the time of polyphenol addition.
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- 2024
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77. Dark Energy Survey Year 3 results: Cosmological constraints from galaxy clustering and weak lensing
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Abbott, TMC, Aguena, M, Alarcon, A, Allam, S, Alves, O, Amon, A, Andrade-Oliveira, F, Annis, J, Avila, S, Bacon, D, Baxter, E, Bechtol, K, Becker, MR, Bernstein, GM, Bhargava, S, Birrer, S, Blazek, J, Brandao-Souza, A, Bridle, SL, Brooks, D, Buckley-Geer, E, Burke, DL, Camacho, H, Campos, A, Rosell, A Carnero, Kind, M Carrasco, Carretero, J, Castander, FJ, Cawthon, R, Chang, C, Chen, A, Chen, R, Choi, A, Conselice, C, Cordero, J, Costanzi, M, Crocce, M, da Costa, LN, da Silva Pereira, ME, Davis, C, Davis, TM, De Vicente, J, DeRose, J, Desai, S, Di Valentino, E, Diehl, HT, Dietrich, JP, Dodelson, S, Doel, P, Doux, C, Drlica-Wagner, A, Eckert, K, Eifler, TF, Elsner, F, Elvin-Poole, J, Everett, S, Evrard, AE, Fang, X, Farahi, A, Fernandez, E, Ferrero, I, Ferté, A, Fosalba, P, Friedrich, O, Frieman, J, García-Bellido, J, Gatti, M, Gaztanaga, E, Gerdes, DW, Giannantonio, T, Giannini, G, Gruen, D, Gruendl, RA, Gschwend, J, Gutierrez, G, Harrison, I, Hartley, WG, Herner, K, Hinton, SR, Hollowood, DL, Honscheid, K, Hoyle, B, Huff, EM, Huterer, D, Jain, B, James, DJ, Jarvis, M, Jeffrey, N, Jeltema, T, Kovacs, A, Krause, E, Kron, R, Kuehn, K, Kuropatkin, N, Lahav, O, Leget, P-F, Lemos, P, Liddle, AR, Lidman, C, and Lima, M
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Astronomical Sciences ,Physical Sciences - Abstract
We present the first cosmology results from large-scale structure using the full 5000 deg2 of imaging data from the Dark Energy Survey (DES) Data Release 1. We perform an analysis of large-scale structure combining three two-point correlation functions (3×2pt): (i) cosmic shear using 100 million source galaxies, (ii) galaxy clustering, and (iii) the cross-correlation of source galaxy shear with lens galaxy positions, galaxy-galaxy lensing. To achieve the cosmological precision enabled by these measurements has required updates to nearly every part of the analysis from DES Year 1, including the use of two independent galaxy clustering samples, modeling advances, and several novel improvements in the calibration of gravitational shear and photometric redshift inference. The analysis was performed under strict conditions to mitigate confirmation or observer bias; we describe specific changes made to the lens galaxy sample following unblinding of the results and tests of the robustness of our results to this decision. We model the data within the flat ΛCDM and wCDM cosmological models, marginalizing over 25 nuisance parameters. We find consistent cosmological results between the three two-point correlation functions; their combination yields clustering amplitude S8=0.776-0.017+0.017 and matter density ωm=0.339-0.031+0.032 in ΛCDM, mean with 68% confidence limits; S8=0.775-0.024+0.026, ωm=0.352-0.041+0.035, and dark energy equation-of-state parameter w=-0.98-0.20+0.32 in wCDM. These constraints correspond to an improvement in signal-to-noise of the DES Year 3 3×2pt data relative to DES Year 1 by a factor of 2.1, about 20% more than expected from the increase in observing area alone. This combination of DES data is consistent with the prediction of the model favored by the Planck 2018 cosmic microwave background (CMB) primary anisotropy data, which is quantified with a probability-to-exceed p=0.13-0.48. We find better agreement between DES 3×2pt and Planck than in DES Y1, despite the significantly improved precision of both. When combining DES 3×2pt data with available baryon acoustic oscillation, redshift-space distortion, and type Ia supernovae data, we find p=0.34. Combining all of these datasets with Planck CMB lensing yields joint parameter constraints of S8=0.812-0.008+0.008, ωm=0.306-0.005+0.004, h=0.680-0.003+0.004, and mν
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- 2022
78. Decision-making about changing medications across transitions of care: Opportunities for enhanced patient and family engagement
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Manias, Elizabeth, Hughes, Carmel, Woodward-Kron, Robyn, Ozavci, Guncag, Jorm, Christine, and Bucknall, Tracey
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- 2024
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79. Partially Ablative Body Radiotherapy (PABR): A novel approach for palliative radiotherapy of locally advanced bulky unresectable sarcomas
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Yu, Kelvin Ken, Yeo, Adam, Ngan, Samuel, Chu, Julie, Chang, David, Siva, Shankar, Wong, Aaron, Kron, Tomas, Hardcastle, Nicholas, Gaudreault, Mathieu, Chesson, Therese, Williams, Siena, Burns, Mark, and Chander, Sarat
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- 2024
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80. Stereotactic ablative body radiotherapy for primary kidney cancer (TROG 15.03 FASTRACK II): a non-randomised phase 2 trial
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Chesson, Brent, Ali, Muhammad, Chander, Sarat, Moore, Alisha, Cook, Olivia, Eade, Thomas, Sharma, Harish, Ramanathan, Muralidas, Howe, Kate, Frewen, Helen, Siva, Shankar, Bressel, Mathias, Sidhom, Mark, Sridharan, Swetha, Vanneste, Ben G L, Davey, Ryan, Montgomery, Rebecca, Ruben, Jeremy, Foroudi, Farshad, Higgs, Braden, Lin, Charles, Raman, Avi, Hardcastle, Nicholas, Hofman, Michael S, De Abreu Lourenco, Richard, Shaw, Mark, Mancuso, Pascal, Moon, Daniel, Wong, Lih-Ming, Lawrentschuk, Nathan, Wood, Simon, Brook, Nicholas R, Kron, Tomas, Martin, Jarad, and Pryor, David
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- 2024
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81. Economic effects of treating postpartum hemorrhage with vacuum-induced hemorrhage control devices – A budget impact analysis of the Jada® System in the German obstetrics setting
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Siefen, Ann-Cathrine, Kurte, Melina S., and Kron, Florian
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- 2024
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82. Surface Processing and Discharge-Conditioning of High Voltage Electrodes for the Ra EDM Experiment
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Ready, Roy A., Arrowsmith-Kron, Gordon, Bailey, Kevin G., Battaglia, Dominic, Bishof, Michael, Coulter, Daniel, Dietrich, Matthew R., Fang, Ruoyu, Hanley, Brian, Huneau, Jake, Kennedy, Sean, Lalain, Peyton, Loseth, Benjamin, McGee, Kellen, Mueller, Peter, O'Connor, Thomas P., O'Kronley, Jordan, Powers, Adam, Rabga, Tenzin, Sanchez, Andrew, Schalk, Eli, Waldo, Dale, Wescott, Jacob, and Singh, Jaideep T.
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Physics - Instrumentation and Detectors ,Physics - Atomic Physics - Abstract
The Ra EDM experiment uses a pair of high voltage electrodes to search for the atomic electric dipole moment of $^{225}$Ra. We use identical, plane-parallel electrodes with a primary high gradient surface of 200 mm$^2$ to generate reversible DC electric fields. Our statistical sensitivity is linearly proportional to the electric field strength in the electrode gap. We adapted surface decontamination and processing techniques from accelerator physics literature to chemical polish and clean a suite of newly fabricated large-grain niobium and grade-2 titanium electrodes. Three pairs of niobium electrodes and one pair of titanium electrodes were discharge-conditioned with a custom high voltage test station at electric field strengths as high as $+52.5$ kV/mm and $-51.5$ kV/mm over electrode gap sizes ranging from 0.4 mm to 2.5 mm. One pair of large-grain niobium electrodes was discharge-conditioned and validated to operate at $\pm 20$ kV/mm with steady-state leakage current $\leq 25$ pA ($1\sigma$) and a polarity-averaged $98 \pm 19$ discharges per hour. These electrodes were installed in the Ra EDM experimental apparatus, replacing a copper electrode pair, and were revalidated to $\pm 20$ kV/mm. The niobium electrodes perform at an electric field strength 3.1 times larger than the legacy copper electrodes and are ultimately limited by the maximum output of our 30 kV bipolar power supply., Comment: 16 pages, 11 figures
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- 2021
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83. The Dark Energy Survey Data Release 2
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DES Collaboration, Abbott, T. M. C., Adamow, M., Aguena, M., Allam, S., Amon, A., Annis, J., Avila, S., Bacon, D., Banerji, M., Bechtol, K., Becker, M. R., Bernstein, G. M., Bertin, E., Bhargava, S., Bridle, S. L., Brooks, D., Burke, D. L., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Castander, F. J., Cawthon, R., Chang, C., Choi, A., Conselice, C., Costanzi, M., Crocce, M., da Costa, L. N., Davis, T. M., De Vicente, J., DeRose, J., Desai, S., Diehl, H. T., Dietrich, J. P., Drlica-Wagner, A., Eckert, K., Elvin-Poole, J., Everett, S., Evrard, A. E., Ferrero, I., Ferté, A., Flaugher, B., Fosalba, P., Friedel, D., Frieman, J., García-Bellido, J., Gelman, L., Gerdes, D. W., Giannantonio, T., Gill, M., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hartley, W. G., Hinton, S. R., Hollowood, D. L., Honscheid, K., Huterer, D., James, D. J., Jeltema, T., Johnson, M. D., Kent, S., Kron, R., Kuehn, K., Kuropatkin, N., Lahav, O., Li, T. S., Lidman, C., Lin, H., MacCrann, N., Maia, M. A. G., Manning, T., March, M., Marshall, J. L., Martini, P., Melchior, P., Menanteau, F., Miquel, R., Morgan, R., Myles, J., Neilsen, E., Ogando, R. L. C., Palmese, A., Paz-Chinchón, F., Petravick, D., Pieres, A., Plazas, A. A., Pond, C., Rodriguez-Monroy, M., Romer, A. K., Roodman, A., Rykoff, E. S., Sako, M., Sanchez, E., Santiago, B., Serrano, S., Sevilla-Noarbe, I., Smith, J. Allyn., Smith, M., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., To, C., Tremblay, P. E., Troxel, M. A., Tucker, D. L., Turner, D. J, Varga, T. N., Walker, A. R., Wechsler, R. H., Weller, J., Wester, W., Wilkinson, R. D., Yanny, B., Zhang, Y., Nikutta, R., Fitzpatrick, M., Jacques, A., Scott, A., Olsen, K., Huang, L., Herrera, D., Juneau, S., Nidever, D., Weaver, B. A., Adean, C., Correia, V., de Freitas, M., Freitas, F. N., Singulani, C., and Vila-Verde, G.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present the second public data release of the Dark Energy Survey, DES DR2, based on optical/near-infrared imaging by the Dark Energy Camera mounted on the 4-m Blanco telescope at Cerro Tololo Inter-American Observatory in Chile. DES DR2 consists of reduced single-epoch and coadded images, a source catalog derived from coadded images, and associated data products assembled from 6 years of DES science operations. This release includes data from the DES wide-area survey covering ~5000 deg2 of the southern Galactic cap in five broad photometric bands, grizY. DES DR2 has a median delivered point-spread function full-width at half maximum of g= 1.11, r= 0.95, i= 0.88, z= 0.83, and Y= 0.90 arcsec photometric uniformity with a standard deviation of < 3 mmag with respect to Gaia DR2 G-band, a photometric accuracy of ~10 mmag, and a median internal astrometric precision of ~27 mas. The median coadded catalog depth for a 1.95 arcsec diameter aperture at S/N= 10 is g= 24.7, r= 24.4, i= 23.8, z= 23.1 and Y= 21.7 mag. DES DR2 includes ~691 million distinct astronomical objects detected in 10,169 coadded image tiles of size 0.534 deg2 produced from 76,217 single-epoch images. After a basic quality selection, benchmark galaxy and stellar samples contain 543 million and 145 million objects, respectively. These data are accessible through several interfaces, including interactive image visualization tools, web-based query clients, image cutout servers and Jupyter notebooks. DES DR2 constitutes the largest photometric data set to date at the achieved depth and photometric precision., Comment: Accepted version. Copyright AAS. Reproduced with permission. 29 pages, 13 figures. Visit https://des.ncsa.illinois.edu/releases/dr2
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- 2021
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84. Precise Photometric Measurements from a 1903 Photographic Plate Using a Commercial Scanner
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Cerny, William, Chapman, Alexis, Glusman, Rowen, Kron, Richard G., Liang, Yingyi, Lin, Jason J., Martinez, Michael N., Medina, Elisabeth, Muratore, Amanda, Ogonor, Buduka, and Sanchez, Jorge A.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We demonstrate the feasibility of determining magnitudes of stars on archival photographic plates using a commercially available scanner. We describe one photometric approach that could serve as a useful example for other studies. In particular, we measure and calibrate stellar magnitudes from a 1903 photographic plate from the Yerkes Observatory collection, and demonstrate that the overall precision from our methods is better than 0.10 mag. Notably, these measurements are dominated by intrinsic plate noise, rather than noise introduced through the scanning/digitization process. The low expense of this approach expands the scientific potential to study variable stars in the archives of observatory plate collections. We use the serendipitous discovery of a candidate transient at photographic magnitude $pg$ = 16.60 in the spiral galaxy NGC 7331 to illustrate our photometric methods. If this unknown source is a supernova, it would represent the fourth known supernova in NGC 7331., Comment: 12 pages, 11 figures, submitting to PASP; comments welcome
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- 2021
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85. 2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure
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Mina K. Chung, Kristen K. Patton, Chu‐Pak Lau, Alexander R. J. Dal Forno, Sana M. Al‐Khatib, Vanita Arora, Ulrika Maria Birgersdotter‐Green, Yong‐Mei Cha, Eugene H. Chung, Edmond M. Cronin, Anne B. Curtis, Iwona Cygankiewicz, Gopi Dandamudi, Anne M. Dubin, Douglas P. Ensch, Taya V. Glotzer, Michael R. Gold, Zachary D. Goldberger, Rakesh Gopinathannair, Eiran Z. Gorodeski, Alejandra Gutierrez, Juan C. Guzman, Weijian Huang, Peter B. Imrey, Julia H. Indik, Saima Karim, Peter P. Karpawich, Yaariv Khaykin, Erich L. Kiehl, Jordana Kron, Valentina Kutyifa, Mark S. Link, Joseph E. Marine, Wilfried Mullens, Seung‐Jung Park, Ratika Parkash, Manuel F. Patete, Rajeev Kumar Pathak, Carlos A. Perona, John Rickard, Mark H. Schoenfeld, Swee‐Chong Seow, Win‐Kuang Shen, Morio Shoda, Jagmeet P. Singh, David J. Slotwiner, Arun Raghav M. Sridhar, Uma N. Srivatsa, Eric C. Stecker, Tanyanan Tanawuttiwat, W. H. Wilson Tang, Carlos Andres Tapias, Cynthia M. Tracy, Gaurav A. Upadhyay, Niraj Varma, Kevin Vernooy, Pugazhendhi Vijayaraman, Sarah Ann Worsnick, Wojciech Zareba, Emily P. Zeitler, Document Reviewers, Nestor Lopez‐Cabanillas, Kenneth A. Ellenbogen, Wei Hua, Takanori Ikeda, Judith A. Mackall, Pamela K. Mason, Christopher J. McLeod, Theofanie Mela, Jeremy P. Moore, and Laurel Kay Racenet
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cardiac resynchronization therapy ,conduction system pacing ,guideline ,his bundle pacing ,left bundle branch area pacing ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system pacing (CSP), has emerged as a pacing therapy strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony or pacing‐induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT for HF therapy and CPP in patients with pacemaker indications or HF, patient selection, pre‐procedure evaluation and preparation, implant procedure management, follow‐up evaluation and optimization of CPP response, and use in pediatric populations. Gaps in knowledge, pointing to new directions for future research, are also identified.
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- 2023
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86. Granulomatous Cardiomyopathy Presenting As a Paraneoplastic Syndrome in Metastatic MelanomaNovel Teaching Points
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Jeffrey Kolominsky, MD, Andrew Poklepovic, MD, Aamer Syed, MD, Valentina Robila, MD, Krishnasree Rao, MD, Inna Tchoukina, MD, Kenneth A. Ellenbogen, MD, Antonio Abbate, MD, Wendy Bottinor, MD, and Jordana Kron, MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2023
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87. Principles and techniques of liver resection
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Kron, Philipp, additional and Lodge, J. Peter A., additional
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- 2023
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88. CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex
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Weihan Liu, Jeffrey L. Kurkewich, Angela Stoddart, Saira Khan, Dhivyaa Anandan, Alexandre N. Gaubil, Donald J. Wolfgeher, Lia Jueng, Stephen J. Kron, and Megan E. McNerney
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CP: Stem cell research ,CP: Molecular biology ,Biology (General) ,QH301-705.5 - Abstract
Summary: CUX1 is a homeodomain-containing transcription factor that is essential for the development and differentiation of multiple tissues. CUX1 is recurrently mutated or deleted in cancer, particularly in myeloid malignancies. However, the mechanism by which CUX1 regulates gene expression and differentiation remains poorly understood, creating a barrier to understanding the tumor-suppressive functions of CUX1. Here, we demonstrate that CUX1 directs the BAF chromatin remodeling complex to DNA to increase chromatin accessibility in hematopoietic cells. CUX1 preferentially regulates lineage-specific enhancers, and CUX1 target genes are predictive of cell fate in vivo. These data indicate that CUX1 regulates hematopoietic lineage commitment and homeostasis via pioneer factor activity, and CUX1 deficiency disrupts these processes in stem and progenitor cells, facilitating transformation.
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- 2024
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89. Development and Introduction of a Disciplinary Data Repository for Sport Scientists Based on the Example MO|RE Data
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Katja Klemm, Klaus Bös, Hannah Kron, Tanja Eberhardt, Alexander Woll, and Claudia Niessner
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Sports science ,repository ,Open Access ,motor performance ,infrastructure ,open data ,Technology - Abstract
In recent decades, the field of sports science has emerged as a discipline characterised by a substantial accumulation of data at the intersection of social and natural sciences. This wealth of data has contributed significantly to our understanding of human performance, training methods, health and well-being and other sport-related phenomena. Data on motor performance have been collected in numerous national and international projects over several decades. The Institute of Sports and Sports Science (IfSS) at the Karlsruhe Institute of Technology (KIT) is one of the largest research centres for human motor performance testing and has funded the Competence Centre for Motor Performance and Motor Testing (KOMET). In 2013, the project group of Klaus Bös and Claudia Niessner registered the need of data management for motor test data in sports science. They started the project “eResearch infrastructure for motor research data”, which was funded by the German Research Foundation in two funding periods from 2014 to 2023. The MO|RE data1 repository emerged from this project. MO|RE data is the first disciplinary repository in sports science and offers these features: publication, search, citation, storage, mapping and harmonisation. During its development and subsequent implementation, it has raised many questions. In general, the basic functions of a repository are well understood, as its overall purpose is clear. However, it is crucial to address the specific needs of the sports science community and different target groups to ensure the repository’s practical utility post-publication. This includes considerations such as data harmonisation through standardisation to a common unit, linking datasets from different surveys, and other measures to enhance usability. With the development of MO|RE data, the project group started an experiment on how specific a repository can be in order to have a defined target group and to address a specific need, and at the same time to be used by enough users to still be relevant and used in the future. Now, MO|RE data has to make the step from project object to routine operation.
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- 2024
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90. Spectroscopic Quantification of Projection Effects in the SDSS redMaPPer Galaxy Cluster Catalogue
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Myles, J., Gruen, D., Mantz, A. B., Allen, S. W., Morris, R. G., Rykoff, E., Costanzi, M., To, C., DeRose, J., Wechsler, R. H., Rozo, E., Jeltema, T., Carrasco, E. R., Kremin, A., and Kron, R.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Projection effects, whereby galaxies along the line-of-sight to a galaxy cluster are mistakenly associated with the cluster halo, present a significant challenge for optical cluster cosmology. We use statistically representative spectral coverage of luminous galaxies to investigate how projection effects impact the low-redshift limit of the Sloan Digital Sky Survey (SDSS) redMaPPer galaxy cluster catalogue. Spectroscopic redshifts enable us to differentiate true cluster members from false positives and determine the fraction of candidate cluster members viewed in projection. Our main results can be summarized as follows: first, we show that a simple double-Gaussian model can be used to describe the distribution of line-of-sight velocities in the redMaPPer sample; second, the incidence of projection effects is substantial, accounting for $\sim 16$ per cent of the weighted richness for the lowest richness objects; third, projection effects are a strong function of richness, with the contribution in the highest richness bin being several times smaller than for low-richness objects; fourth, our measurement has a similar amplitude to state-of-the-art models, but finds a steeper dependence of projection effects on richness than these models; and fifth, the slope of the observed velocity dispersion--richness relation, corrected for projection effects, implies an approximately linear relationship between the true, three-dimensional halo mass and three-dimensional richness. Our results provide a robust, empirical description of the impact of projection effects on the SDSS redMaPPer cluster sample and exemplify the synergies between optical imaging and spectroscopic data for studies of galaxy cluster astrophysics and cosmology., Comment: 12 pages, 9 figures
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- 2020
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91. Dark Energy Survey Year 3 Results: Weak Lensing Shape Catalogue
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Gatti, M., Sheldon, E., Amon, A., Becker, M., Troxel, M., Choi, A., Doux, C., MacCrann, N., Alsina, A. Navarro, Harrison, I., Gruen, D., Bernstein, G., Jarvis, M., Secco, L. F., Ferté, A., Shin, T., McCullough, J., Rollins, R. P., Chen, R., Chang, C., Pandey, S., Tutusaus, I., Prat, J., Elvin-Poole, J., Sanchez, C., Plazas, A. A., Roodman, A., Zuntz, J., Abbott, T. M. C., Aguena, M., Allam, S., Annis, J., Avila, S., Bacon, D., Bertin, E., Bhargava, S., Brooks, D., Burke, D. L., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Castander, F. J., Conselice, C., Costanzi, M., da Costa, L. N., Davis, T. M., De Vicente, J., Desai, S., Diehl, H. T., Dietrich, J. P., Doel, P., Drlica-Wagner, A., Eckert, K., Everett, S., Ferrero, I., Frieman, J., García-Bellido, J., Gerdes, D. W., Giannantonio, T., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hartley, W. G., Hinton, S. R., Hollowood, D. L., Honscheid, K., Hoyle, B., Huff, E. M., Huterer, D., Jain, B., James, D. J., Jeltema, T., Krause, E., Kron, R., Kuropatkin, N., Lahav, O., Lima, M., Maia, M. A. G., Marshall, J. L., Miquel, R., Morgan, R., Myles, J., Palmese, A., Paz-Chinchón, F., Rykoff, E. S., Samuroff, S., Sanchez, E., Scarpine, V., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Smith, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., To, C., Tucker, D. L., Varga, T. N., Wechsler, R. H., Weller, J., Wester, W., and Wilkinson, R. D.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present and characterise the galaxy shape catalogue from the first 3 years of Dark Energy Survey (DES) observations, over an effective area of ~4143 deg$^2$ of the southern sky. We describe our data analysis process and our self-calibrating shear measurement pipeline METACALIBRATION, which builds and improves upon the pipeline used in the DES Year 1 analysis in several aspects. The DES Year 3 weak-lensing shape catalogue consists of 100,204,026 galaxies, measured in the $riz$ bands, resulting in a weighted source number density of $n_{\rm eff} = 5.59$ gal/arcmin$ ^{2}$ and corresponding shape noise $\sigma_e = 0.261$. We perform a battery of internal null tests on the catalogue, including tests on systematics related to the point-spread function (PSF) modelling, spurious catalogue B-mode signals, catalogue contamination, and galaxy properties., Comment: Accepted by MNRAS. See https://www.darkenergysurvey.org/des-year-3-cosmology-results-papers/ for the full DES Y3 cosmology release
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- 2020
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92. Dark Energy Survey Year 3 Results: Photometric Data Set for Cosmology
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Sevilla-Noarbe, I., Bechtol, K., Kind, M. Carrasco, Rosell, A. Carnero, Becker, M. R., Drlica-Wagner, A., Gruendl, R. A., Rykoff, E. S., Sheldon, E., Yanny, B., Alarcon, A., Allam, S., Amon, A., Benoit-Lévy, A., Bernstein, G. M., Bertin, E., Burke, D. L., Carretero, J., Choi, A., Diehl, H. T., Everett, S., Flaugher, B., Gaztanaga, E., Gschwend, J., Harrison, I., Hartley, W. G., Hoyle, B., Jarvis, M., Johnson, M. D., Kessler, R., Kron, R., Kuropatkin, N., Leistedt, B., Li, T. S., Menanteau, F., Morganson, E., Ogando, R. L. C., Palmese, A., Paz-Chinchón, F., Pieres, A., Pond, C., Rodriguez-Monroy, M., Allyn-Smith, J., Stringer, K. M., Troxel, M. A., Tucker, D. L., de Vicente, J., Wester, W., Zhang, Y., Abbott, T. M. C., Aguena, M., Annis, J., Avila, S., Bhargava, S., Bridle, S. L., Brooks, D., Brout, D., Castander, F. J., Cawthon, R., Chang, C., Conselice, C., Costanzi, M., Crocce, M., da Costa, L. N., Pereira, M. E. E., Davis, T. M., Desai, S., Dietrich, J. P., Doel, P., Eckert, K., Evrard, A. E., Ferrero, I., Fosalba, P., García-Bellido, J., Gerdes, D. W., Giannantonio, T., Gruen, D., Gutierrez, G., Hinton, S. R., Hollowood, D. L., Honscheid, K., Huff, E. M., Huterer, D., James, D. J., Jeltema, T., Kuehn, K., Lahav, O., Lidman, C., Lima, M., Lin, H., Maia, M. A. G., Marshall, J. L., Martini, P., Melchior, P., Miquel, R., Mohr, J. J., Morgan, R., Neilsen, E., Plazas, A. A., Romer, A. K., Roodman, A., Sanchez, E., Scarpine, V., Schubnell, M., Serrano, S., Smith, M., Suchyta, E., Tarle, G., Thomas, D., To, C., Varga, T. N., Wechsler, R. H., Weller, J., and Wilkinson, R. D.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We describe the Dark Energy Survey (DES) photometric data set assembled from the first three years of science operations to support DES Year 3 cosmology analyses, and provide usage notes aimed at the broad astrophysics community. Y3 Gold improves on previous releases from DES, Y1 Gold and Data Release 1 (DES DR1), presenting an expanded and curated data set that incorporates algorithmic developments in image detrending and processing, photometric calibration, and object classification. Y3 Gold comprises nearly 5000 square degrees of grizY imaging in the south Galactic cap, including nearly 390 million objects, with depth reaching S/N ~ 10 for extended objects up to $i_{AB}\sim 23.0$, and top-of-the-atmosphere photometric uniformity $< 3$ mmag. Compared to DR1, photometric residuals with respect to Gaia are reduced by $50\%$, and per-object chromatic corrections are introduced. Y3 Gold augments DES DR1 with simultaneous fits to multi-epoch photometry for more robust galaxy color measurements and corresponding photometric redshift estimates. Y3 Gold features improved morphological star-galaxy classification with efficiency $>98\%$ and purity $>99\%$ for galaxies with $19 < i_{AB} < 22.5$. Additionally, it includes per-object quality information, and accompanying maps of the footprint coverage, masked regions, imaging depth, survey conditions, and astrophysical foregrounds that are used to select the cosmology analysis samples. This paper will be complemented by online resources., Comment: see https://www.darkenergysurvey.org/des-year-3-cosmology-results-papers/ for the full DES Y3 cosmology release
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- 2020
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93. Dark Energy Survey Year 1 Results: Cosmological Constraints from Cluster Abundances, Weak Lensing, and Galaxy Correlations
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To, C., Krause, E., Rozo, E., Wu, H., Gruen, D., Wechsler, R. H., Eifler, T. F., Rykoff, E. S., Costanzi, M., Becker, M. R., Bernstein, G. M., Blazek, J., Bocquet, S., Bridle, S. L., Cawthon, R., Choi, A., Crocce, M., Davis, C., DeRose, J., Drlica-Wagner, A., Elvin-Poole, J., Fang, X., Farahi, A., Friedrich, O., Gatti, M., Gaztanaga, E., Giannantonio, T., Hartley, W. G., Hoyle, B., Jarvis, M., MacCrann, N., McClintock, T., Miranda, V., Pereira, M. E. S., Park, Y., Porredon, A., Prat, J., Rau, M. M., Ross, A. J., Samuroff, S., Sánchez, C., Sevilla-Noarbe, I., Sheldon, E., Troxel, M. A., Varga, T. N., Vielzeuf, P., Zhang, Y., Zuntz, J., Abbott, T. M. C., Aguena, M., Annis, J., Avila, S., Bertin, E., Bhargava, S., Brooks, D., Burke, D. L., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Chang, C., Conselice, C., da Costa, L. N., Davis, T. M., Desai, S., Diehl, H. T., Dietrich, J. P., Everett, S., Evrard, A. E., Ferrero, I., Flaugher, B., Fosalba, P., Frieman, J., García-Bellido, J., Gruendl, R. A., Gutierrez, G., Hinton, S. R., Hollowood, D. L., Huterer, D., James, D. J., Jeltema, T., Kron, R., Kuehn, K., Kuropatkin, N., Lima, M., Maia, M. A. G., Marshall, J. L., Menanteau, F., Miquel, R., Morgan, R., Muir, J., Myles, J., Palmese, A., Paz-Chinchón, F., Plazas, A. A., Romer, A. K., Roodman, A., Sanchez, E., Santiago, B., Scarpine, V., Serrano, S., Smith, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., Tucker, D. L., Weller, J., and Wester, W.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Combining multiple observational probes is a powerful technique to provide robust and precise constraints on cosmological parameters. In this letter, we present the first joint analysis of cluster abundances and auto/cross correlations of three cosmic tracer fields measured from the first year data of the Dark Energy Survey: galaxy density, weak gravitational lensing shear, and cluster density split by optical richness. From a joint analysis of cluster abundances, three cluster cross-correlations, and auto correlations of galaxy density, we obtain $\Omega_{\rm{m}}=0.305^{+0.055}_{-0.038}$ and $\sigma_8=0.783^{+0.064}_{-0.054}$. This result is consistent with constraints from the DES-Y1 galaxy clustering and weak lensing two-point correlation functions for the flat $\nu\Lambda$CDM model. We thus combine cluster abundances and all two-point correlations from three cosmic tracer fields and find improved constraints on cosmological parameters as well as on the cluster observable--mass scaling relation. This analysis is an important advance in both optical cluster cosmology and multi-probe analyses of upcoming wide imaging surveys., Comment: 14 pages, 7 figures, 2 tables; submitted to PRL; comments are welcome
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- 2020
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94. Noise from Undetected Sources in Dark Energy Survey Images
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Eckert, K., Bernstein, G. M., Amara, A., Amon, A., Choi, A., Everett, S., Gruen, D., Gruendl, R. A., Huff, E. M., Kuropatkin, N., Roodman, A., Sheldon, E., Yanny, B., Zhang, Y., Abbott, T. M. C., Aguena, M., Avila, S., Bechtol, K., Brooks, D., Burke, D. L., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., De Vicente, J., Desai, S., Diehl, H. T., Dietrich, J. P., Eifler, T. F., Evrard, A. E., Flaugher, B., Frieman, J., García-Bellido, J., Gaztanaga, E., Gschwend, J., Gutierrez, G., Hartley, W. G., Hollowood, D. L., Honscheid, K., James, D. J., Kron, R., Kuehn, K., Maia, M. A. G., Marshall, J. L., Melchior, P., Menanteau, F., Miquel, R., Ogando, R. L. C., Palmese, A., Paz-Chinchón, F., Plazas, A. A., Romer, A. K., Sanchez, E., Scarpine, V., Serrano, S., Sevilla-Noarbe, I., Smith, M., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., Varga, T. N., Walker, A. R., Wester, W., Wilkinson, R. D., Zuntz, J., and Collaboration, the DES
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
For ground-based optical imaging with current CCD technology, the Poisson fluctuations in source and sky background photon arrivals dominate the noise budget and are readily estimated. Another component of noise, however, is the signal from the undetected population of stars and galaxies. Using injection of artificial galaxies into images, we demonstrate that the measured variance of galaxy moments (used for weak gravitational lensing measurements) in Dark Energy Survey (DES) images is significantly in excess of the Poisson predictions, by up to 30\%, and that the background sky levels are overestimated by current software. By cross-correlating distinct images of "empty" sky regions, we establish that there is a significant image noise contribution from undetected static sources (US), which on average are mildly resolved at DES resolution. Treating these US as a stationary noise source, we compute a correction to the moment covariance matrix expected from Poisson noise. The corrected covariance matrix matches the moment variances measured on the injected DES images to within 5\%. Thus we have an empirical method to statistically account for US in weak lensing measurements, rather than requiring extremely deep sky simulations. We also find that local sky determinations can remove the bias in flux measurements, at a small penalty in additional, but quantifiable, noise., Comment: 13 pages, 10 figures
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- 2020
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95. Self-expandable metallic stent as bridge to surgery vs. emergency resection in obstructive right-sided colon cancer: a systematic review and meta-analysis
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Mäder, Mirjam, Kalt, Fabian, Schneider, Marcel, Kron, Philipp, Ramser, Michaela, Lopez-Lopez, Victor, Biondo, Sebastiano, Faucheron, Jean-Luc, Yoshiyuki, Suzuki, von der Groeben, Markus, Novak, Allan, Teufelberger, Gerfried, Lehmann, Kuno, and Eshmuminov, Dilmurodjon
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- 2023
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96. Designing a wholly online, multidisciplinary Master of Cancer Sciences degree
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Lai-Kwon, Julia, Dushyanthen, Sathana, Seignior, David, Barrett, Michelle, Buisman-Pijlman, Femke, Buntine, Andrew, Woodward-Kron, Robyn, McArthur, Grant, and Kok, David L
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- 2023
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97. Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy.
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Prasanna, Pataje G, Citrin, Deborah E, Hildesheim, Jeffrey, Ahmed, Mansoor M, Venkatachalam, Sundar, Riscuta, Gabriela, Xi, Dan, Zheng, Guangrong, Deursen, Jan van, Goronzy, Jorg, Kron, Stephen J, Anscher, Mitchell S, Sharpless, Norman E, Campisi, Judith, Brown, Stephen L, Niedernhofer, Laura J, O'Loghlen, Ana, Georgakilas, Alexandros G, Paris, Francois, Gius, David, Gewirtz, David A, Schmitt, Clemens A, Abazeed, Mohamed E, Kirkland, James L, Richmond, Ann, Romesser, Paul B, Lowe, Scott W, Gil, Jesus, Mendonca, Marc S, Burma, Sandeep, Zhou, Daohong, and Coleman, C Norman
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Cancer ,Prevention ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis - Abstract
Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction of tumor cell senescence is also one of the underlying mechanisms by which cancer therapies exert antitumor activity. However, an increasing body of evidence from preclinical studies demonstrates that radiation and chemotherapy cause accumulation of senescent cells (SnCs) both in tumor and normal tissue. SnCs in tumors can, paradoxically, promote tumor relapse, metastasis, and resistance to therapy, in part, through expression of the senescence-associated secretory phenotype. In addition, SnCs in normal tissue can contribute to certain radiation- and chemotherapy-induced side effects. Because of its multiple roles, cellular senescence could serve as an important target in the fight against cancer. This commentary provides a summary of the discussion at the National Cancer Institute Workshop on Radiation, Senescence, and Cancer (August 10-11, 2020, National Cancer Institute, Bethesda, MD) regarding the current status of senescence research, heterogeneity of therapy-induced senescence, current status of senotherapeutics and molecular biomarkers, a concept of "one-two punch" cancer therapy (consisting of therapeutics to induce tumor cell senescence followed by selective clearance of SnCs), and its integration with personalized adaptive tumor therapy. It also identifies key knowledge gaps and outlines future directions in this emerging field to improve treatment outcomes for cancer patients.
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- 2021
98. Therapy-Induced Senescence: Opportunities to Improve Anti-Cancer Therapy
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Prasanna, Pataje G, Citrin, Deborah E, Hildesheim, Jeffrey, Ahmed, Mansoor M, Venkatachalam, Sundar, Riscuta, Gabriela, Xi, Dan, Zheng, Guangrong, van Deursen, Jan, Goronzy, Jorg, Kron, Stephen J, Anscher, Mitchell S, Sharpless, Norman E, Campisi, Judith, Brown, Stephen L, Niedernhofer, Laura J, O'Loghlen, Ana, Georgakilas, Alexandros G, Paris, Francois, Gius, David, Gewirtz, David A, Schmitt, Clemens A, Abazeed, Mohamed E, Kirkland, James L, Richmond, Ann, Romesser, Paul B, Lowe, Scott W, Gil, Jesus, Mendonca, Marc S, Burma, Sandeep, Zhou, Daohong, and Coleman, C Norman
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Cancer ,Prevention ,Good Health and Well Being ,Biomarkers ,Cellular Senescence ,Humans ,Neoplasms ,Senescence-Associated Secretory Phenotype ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction of tumor cell senescence is also one of the underlying mechanisms by which cancer therapies exert antitumor activity. However, an increasing body of evidence from preclinical studies demonstrates that radiation and chemotherapy cause accumulation of senescent cells (SnCs) both in tumor and normal tissue. SnCs in tumors can, paradoxically, promote tumor relapse, metastasis, and resistance to therapy, in part, through expression of the senescence-associated secretory phenotype. In addition, SnCs in normal tissue can contribute to certain radiation- and chemotherapy-induced side effects. Because of its multiple roles, cellular senescence could serve as an important target in the fight against cancer. This commentary provides a summary of the discussion at the National Cancer Institute Workshop on Radiation, Senescence, and Cancer (August 10-11, 2020, National Cancer Institute, Bethesda, MD) regarding the current status of senescence research, heterogeneity of therapy-induced senescence, current status of senotherapeutics and molecular biomarkers, a concept of "one-two punch" cancer therapy (consisting of therapeutics to induce tumor cell senescence followed by selective clearance of SnCs), and its integration with personalized adaptive tumor therapy. It also identifies key knowledge gaps and outlines future directions in this emerging field to improve treatment outcomes for cancer patients.
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- 2021
99. The DaanMatch System: Matching NGOs with CSRs using the UN Sustainable Development Goals.
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Cara Arellano, Michael DeBellis, Patrick Guo, Kenneth Kron, Tejas Jyothi, and V. Suresh
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- 2023
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100. Ambulantisierung und Vergütungssystematik im deutschen Gesundheitssystem: Eine Bestandaufnahme und kritische Analyse der aktuellen Reformvorhaben der Bundesregierung
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Dengler, Robert, Kron, Florian, Cassens, Manfred, editor, and Städter, Thomas, editor
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- 2023
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