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1,314 results on '"Kristiansen, G."'

52. Cognitive Sociolinguistics from the perspective of recontextualization

Author

Foolen, A.P., Kristiansen, G., Franco, K., De Pascale, S., Rosseel, L., Zhang, W., Kristiansen, G., Franco, K., De Pascale, S., Rosseel, L., and Zhang, W.

Subjects
niet-RU-publicaties, Perspective (graphical), Sociology, Applications of Cognitive Linguistics [ACL], Cognitive sociolinguistics, Epistemology
Abstract

Item does not contain fulltext

Published
2021

64. PDCD1 methylation predicts response to anti–PD-1 based immunotherapy in advanced and metastatic renal cell carcinoma

Author

Klümper, N., primary, Ralser, D.J., additional, Zarbl, R., additional, Schlack, K., additional, Schrader, A.J., additional, Rehlinghaus, M., additional, Hoffmann, M.J., additional, Niegisch, G., additional, Uhlig, A., additional, Trojan, L., additional, Steinestel, J., additional, Steinestel, K., additional, Wirtz, R.M., additional, Kristiansen, G., additional, Toma, M., additional, Hölzel, M., additional, Ritter, M., additional, Strieth, S., additional, Ellinger, J., additional, and Dietrich, D., additional

Published
2021
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65. From Big Brother to Ikea

Author

Grondelaers, S.A., Hout, R.W.N.M. van, Kristiansen, G., Franco, K., De Pascale, S., Rosseel, L., and Zhang, W.

Subjects
Applications of Cognitive Linguistics [ACL]
Published
2021

67. From Big Brother to Ikea

Author

Kristiansen, G., Franco, K., De Pascale, S., Rosseel, L., Zhang, W., Grondelaers, S.A., Hout, R.W.N.M. van, Kristiansen, G., Franco, K., De Pascale, S., Rosseel, L., Zhang, W., Grondelaers, S.A., and Hout, R.W.N.M. van

Abstract

Item does not contain fulltext

Published
2021

74. Ist durch den hochselektiven Cyclooxigenase-2-Inhibitor Parecoxib über eine Verminderung des pankreatischen Eicosanoidstoffwechsels eine Reduktion des histopathologischen Schweregrades der akuten nekrotisierenden Pankreatitis der Ratte möglich?

Author

Hanel, M., Kilian, M., Gregor, J. I., Heukamp, I., Walz, M. K., Kristiansen, G., Wenger, F. A., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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84. Identification of miR-21-5p and miR-210-3p serum levels as biomarkers for patients with papillary renal cell carcinoma: a multicenter analysis

Author

Kalogirou, C., Ellinger, J., Kristiansen, G., Hatzichristodoulou, G., Kübler, H., Kneitz, B., Busch, J., and Fendler, A.

Subjects
Cancer Research
Abstract

BACKGROUND: Expression of circulating serum microRNAs has not been studied in a cohort of patients with papillary renal cell carcinoma (pRCC) so far. We hypothesized that miRNA deregulation in malignant tissue is reflected in serum and could be used for non-invasive diagnosis of pRCC as well as differentiation between type 1 and type 2 pRCC. METHODS: We selected 11 differentially regulated miRNAs from the Cancer Genome Atlas (TCGA) pRCC data set as potential serum validation candidates. Serum miRNA expression was determined by qRT-PCR in a total of 34 pRCC type 1, 33 pRCC type 2 and 33 control subjects of three german high-volume medical centers. RESULTS: Heatmap and principal component analysis showed that miRNA expression did not cluster the samples into distinct sample groups and that miRNA levels did not significantly discriminate healthy individuals from patients with pRCC, nor between patients with type 1 and type 2 pRCC. However, miR-21-5p levels were significantly increased in patients with advanced pRCC (>pT3, and/or pN+ and/or pM+) in comparison to localized pRCC. Moreover, adding the expression of miR-210-3p, which was significantly down-regulated in localized pRCC sera in comparison to healthy sera, additionally increased diagnostic accuracy in our study cohort. CONCLUSIONS: In our multicenter cohort, we were not able to identify a single miRNA serum marker for pRCC including its subclasses. However, our study revealed that miR-21-5p levels were elevated in advanced disease (with added diagnostic accuracy via addition of miR-210-3p expression), proposing these two miRs as potential biomarkers in pRCC.

Published
2020

85. Expression des Mikrotubuli-assoziierten Proteins 2 (MAP2) im klarzelligen Nierenzellkarzinom

Author

Stein, J, Klümper, N, Cox, A, Ellinger, J, Kristiansen, G, Ritter, M, and Majores, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Das Mikrotubuli-assoziierte Protein 2 (MAP2) ist ein Vertreter der Mikrotubuli-assoziierten Proteine (MAPs) der MAP2/Tau-Familie. MAP2 ist bekannt als ein dendritisches Strukturprotein, das im dendritischen Zytoplasma von Nervenzellen vorliegt. Es spielt eine entscheidende Rolle für[zum vollständigen Text gelangen Sie über die oben angegebene URL], 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie

Published
2020
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89. The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

Author

Leenders, Geert J. L. H. van, Kwast, Theodorus H. van der, Grignon, David J., Evans, Andrew J., Kristiansen, G., Kweldam, Charlotte F., Litjens, G.J., Williamson, Sean R., Iczkowski, Kenneth A., Leenders, Geert J. L. H. van, Kwast, Theodorus H. van der, Grignon, David J., Evans, Andrew J., Kristiansen, G., Kweldam, Charlotte F., Litjens, G.J., Williamson, Sean R., and Iczkowski, Kenneth A.

Abstract

Contains fulltext : 222199.pdf (Publisher’s version ) (Open Access)

Published
2020

90. The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

Author

Leenders, G.J.H.L. (Geert), Kwast, Th.H. (Theo) van der, Grignon, D.J., Evans, AJ, Kristiansen, G. (Glen), Kweldam, C.F. (Charlotte), Litjens, G., McKenney, JK, Melamed, J. (Jonathan), Mottet, N. (Nicolas), Paner, G.P., Samaratunga, H, Schoots, I.G. (Ivo), Simko, J.P., Tsuzuki, T., Varma, M, Warren, AY, Wheeler, T.M. (Thomas), Williamson, S.R., Iczkowski, KA, Leenders, G.J.H.L. (Geert), Kwast, Th.H. (Theo) van der, Grignon, D.J., Evans, AJ, Kristiansen, G. (Glen), Kweldam, C.F. (Charlotte), Litjens, G., McKenney, JK, Melamed, J. (Jonathan), Mottet, N. (Nicolas), Paner, G.P., Samaratunga, H, Schoots, I.G. (Ivo), Simko, J.P., Tsuzuki, T., Varma, M, Warren, AY, Wheeler, T.M. (Thomas), Williamson, S.R., and Iczkowski, KA

Abstract

Five years after the last prostatic carcinoma grading consensus conference of the International Society of Urological Pathology (ISUP), accrual of new data and modification of clinical practice require an update of current pathologic grading guidelines. This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France. Topics brought to consensus included the following: (1) approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns, (2) an agreement to report the presence of invasive cribriform carcinoma, (3) an agreement to incorporate intraductal carcinoma into grading, and (4) individual versus aggregate grading of systematic and multiparametric magnetic resonance imaging–targeted biopsies. Finally, developments in the field of artificial intelligence in the grading of prostatic carcinoma and future research perspectives were discussed.

Published
2020
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93. LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma.

Author

Klümper, N, Ralser, DJ, Bawden, EG, Landsberg, J, Zarbl, R, Kristiansen, G, Toma, M, Ritter, M, Hölzel, M, Ellinger, J, Dietrich, D, Klümper, N, Ralser, DJ, Bawden, EG, Landsberg, J, Zarbl, R, Kristiansen, G, Toma, M, Ritter, M, Hölzel, M, Ellinger, J, and Dietrich, D

Abstract

BACKGROUND: Lymphocyte activating 3 (LAG3, LAG-3, CD223) is a promising target for immune checkpoint inhibition in clear cell renal cell carcinoma (KIRC). The aim of this study was to investigate the epigenetic regulation of LAG3 in KIRC by methylation. METHODS: We correlated quantitative LAG3 methylation levels with transcriptional activity, immune cell infiltration, and overall survival in a cohort of n=533 patients with KIRC and n=160 normal adjacent tissue (NAT) samples obtained from The Cancer Genome Atlas (TCGA). Furthermore, we analyzed LAG3 methylation in peripheral blood mononuclear cells (PBMCs) and KIRC cell lines. We validated correlations between LAG3 expression, immune cell infiltrates, survival, and methylation in an independent KIRC cohort (University Hospital Bonn (UHB) cohort, n=118) by means of immunohistochemistry and quantitative methylation-specific PCR. RESULTS: We found differential methylation profiles among PBMCs, NAT, KIRC cell lines, and KIRC tumor tissue. Methylation strongly correlated with LAG3 mRNA expression in KIRCs (TCGA cohort) and KIRC cell lines. In the UHB cohort, methylation correlated with LAG3-positive immune cells and tumor-intrinsic LAG3 protein expression. Furthermore, LAG3 methylation strongly correlated with signatures of distinct immune cell infiltrates, an interferon-y signature (TCGA cohort), and immunohistochemically quantified CD45+, CD8+, and CD4+ immune cell infiltrates (UHB cohort). LAG3 mRNA expression (TCGA cohort), methylation (both cohorts), and tumor cell-intrinsic protein expression (UHB cohort) was significantly associated with overall survival. CONCLUSION: Our data suggest an epigenetic regulation of LAG3 expression in tumor and immune cells via DNA methylation. LAG3 expression and methylation is associated with a subset of KIRCs showing a distinct clinical course and immunogenicity. Our study provides rationale for further testing LAG3 DNA methylation as a predictive biomarker for response to LAG3 immun

Published
2020

96. The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

Author

van Leenders, Arno, Kwast, Theodorus, Grignon, DJ, Evans, AJ, Kristiansen, G, Kweldam, Charlotte, Litjens, G, McKenney, JK, Melamed, J, Mottet, N, Paner, GP, Samaratunga, H, Schoots, Ivo, Simko, JP, Tsuzuki, T, Varma, M, Warren, AY, Wheeler, TM, Williamson, SR, Iczkowski, KA, van Leenders, Arno, Kwast, Theodorus, Grignon, DJ, Evans, AJ, Kristiansen, G, Kweldam, Charlotte, Litjens, G, McKenney, JK, Melamed, J, Mottet, N, Paner, GP, Samaratunga, H, Schoots, Ivo, Simko, JP, Tsuzuki, T, Varma, M, Warren, AY, Wheeler, TM, Williamson, SR, and Iczkowski, KA

Published
2020

97. Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma (NVUC)

Author

Weyerer, V., Weisser, R., Moskalev, E.A., Haller, F., Stoehr, R., Eckstein, M., Zinnall, U., Gaisa, N.T., Compérat, E., Perren, A., Keck, B., Allory, Y., Kristiansen, G., Wullich, B., Agaimy, A., Hartmann, A., and Bertz, S.

Subjects
Cancer Research
Abstract

AIMS: Nested variant of urothelial carcinoma (NVUC) is rare and only few small series exist. Molecular characteristics and the classifying marker profile as well as therapeutic targets of this specific variant are mostly unknown. Aim of this study was to characterize NVUC on the molecular level in one of the largest cohorts to date. In addition, we applied an immunohistochemical marker panel in order to define the molecular subtype. METHODS: 60 NVUC cases were collected from different departments. TERT mutation analysis was carried out in all samples using SNaPshot analysis. Target sequencing of 48 cancer related genes by Next Generation Sequencing (NGS) analysis was performed in a subset of 26 cases. Immunohistochemical markers CD44, CK5, CK14, EGFR, p63, FOXA1, GATA3, CD24 und CK20 were used to elucidate the molecular subtype. RESULTS: A total of 62.5% of NVUC cases harbored a mutation of the TERT promoter. Additionally, TP53, JAK3, and CTNNB1 were among the most frequently mutated genes identified by NGS analysis. Subtyping revealed that all NVUC express luminal markers such as CD24, FOXA1, GATA3 and CK20. CONCLUSIONS: Summarized, NVUC belong to the luminal molecular subtype. Moreover, a subset of NVUC seems to be characterized by mutations of the Wnt- and inflammatory pathway, including JAK3 mutations, indicating a different biological background compared to conventional urothelial bladder cancer.

Published
2019

99. Cytoplasmic overexpression of ALCAM is prognostic of disease progression in breast cancer

Author

Burkhardt, M., Mayordomo, E., Winzer, K.-J., Fritzsche, F., Gansukh, T., Pahl, S., Weichert, W., Denkert, C., Guski, H., Dietel, M., and Kristiansen, G.

Subjects
Breast cancer -- Development and progression, Cancer patients -- Prognosis, Cell adhesion molecules -- Analysis, Leukocytes -- Analysis, Gene expression -- Analysis, Immunohistochemistry -- Usage, Health
Published
2006

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