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267 results on '"Krisa, Stéphanie"'

51. Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation

Author

Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Ministerio de Economía y Competitividad (MINECO). España, Hornedo Ortega, Ruth, Cerezo López, Ana Belén, Martínez de Pablos, Rocío, Krisa, Stéphanie, Richard, Tristan, García Parrilla, María del Carmen, Troncoso González, Ana María, Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Ministerio de Economía y Competitividad (MINECO). España, Hornedo Ortega, Ruth, Cerezo López, Ana Belén, Martínez de Pablos, Rocío, Krisa, Stéphanie, Richard, Tristan, García Parrilla, María del Carmen, and Troncoso González, Ana María

Abstract

Neuroinflammation is a pathological feature of quite a number of Central Nervous System diseases such as Alzheimer and Parkinson’s disease among others. The hallmark of brain neuroinflammation is the activation of microglia, which are the immune resident cells in the brain and represents the first line of defense when injury or disease occur. Microglial activated cells can adopt different phenotypes to carry out its diverse functions. Thus, the shift into pro-inflammatory/neurotoxic or anti-inflammatory/neuroprotective phenotypes, depending of the brain environment, has totally changed the understanding of microglia in neurodegenerative disease. For this reason, novel therapeutic strategies which aim to modify the microglia polarization are being developed. Additionally, the understanding of how nutrition may influence the prevention and/or treatment of neurodegenerative diseases has grown greatly in recent years. The protective role of Mediterranean diet (MD) in preventing neurodegenerative diseases has been reported in a number of studies. The Mediterranean dietary pattern includes as distinctive features the moderate intake of red wine and extra virgin olive oil, both of them rich in polyphenolic compounds, such as resveratrol, oleuropein and hydroxytyrosol and their derivatives, which have demonstrated anti-inflammatory effects on microglia on in vitro studies. This review summarizes our understanding of the role of dietary phenolic compounds characteristic of the MD in mitigating microglia-mediated neuroinflammation, including explanation regarding their bioavailability, metabolism and blood–brain barrier.

Published
2018

54. Effects of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats: modulation of it by rutin and other micronutrients

Author

Gatineau, Eva, primary, Cluzet, Stéphanie, additional, Krisa, Stéphanie, additional, Papet, Isabelle, additional, Migne, Carole, additional, Remond, Didier, additional, Dardevet, Dominique, additional, Polakof, Sergio, additional, Richard, Tristan, additional, and Mosoni, Laurent, additional

Published
2018
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61. Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption

Author

Mével, Elsa, primary, Merceron, Christophe, additional, Vinatier, Claire, additional, Krisa, Stéphanie, additional, Richard, Tristan, additional, Masson, Martial, additional, Lesoeur, Julie, additional, Hivernaud, Vincent, additional, Gauthier, Olivier, additional, Abadie, Jérôme, additional, Nourissat, Geoffroy, additional, Houard, Xavier, additional, Wittrant, Yohann, additional, Urban, Nelly, additional, Beck, Laurent, additional, and Guicheux, Jérôme, additional

Published
2016
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65. LC-MS identification and preparative HPLC isolation of Frankenia pulverulenta phenolics with antioxidant and neuroprotective capacities in PC12 cell line.

Author

Ben Mansour, Rim, Wided, Megdiche Ksouri, Cluzet, Stéphanie, Krisa, Stéphanie, Richard, Tristan, and Ksouri, Riadh

Subjects
FRANKENIA, ANTIOXIDANTS, NEUROPROTECTIVE agents, PHENOLS, ETHYL acetate, CELL lines, GALLIC acid, QUERCETIN, THERAPEUTICS
Abstract

Context:Frankenia pulverulentaL. (Frankeniaceae) is a medicinal species with carminative, analgesic and antiviral properties. However, phytochemical investigations, antioxidant and neuroprotective capacities of this plant remain unclear. Objective:This work assesses the phenolic composition ofF. pulverulentashoot and root and evaluates their antioxidant and neuroprotective capacities. Materials and methods:Successive fractionation ofF. pulverulentashoot and root using 6 solvents were used. Antioxidant capacity of these fractions was assessed through fourin vitrotests (DPPH, ABTS, Fe-chelating activity and ORAC). Phenolic identification, purification as well as neuroprotective activity of ethyl acetate (EtOAc) fraction and purified molecules were assessed. Results:Among the tested fractions, EtOAc shoot and root fractions possessed considerable phenolic contents (383 and 374 mg GAE/g E, respectively) because of their important ORAC (821 and 1054 mg of TE/g E), DPPH (586 and 750 mg of TE/g) and ABTS (1453 and 1319 mg of TE/g) results. Moreover, gallic acid, quercetin, quercetin galloyl glucoside, trigalloyl hexoside, procyanidin dimers and sulfated flavonoids were identified by LC-DAD-ESI-MS for the first time in this species. The relevant cytoprotective capacity (at 300 μg/mL) against β-amyloid peptide induced toxicity in PC12 cells of EtOAc fractions were corroborated with the chemical composition. In addition, purified molecules were tested for their ORAC and neuroprotective activity. Quercetin showed the best ORAC value (33.55 mmol TE/g polyphenols); nevertheless, procyanidin dimer exhibited an exceptionally efficient neuroprotective activity (100% of viability at 50 μg/mL). Discussion and conclusions:These findings suggest that this halophyte is a promising source of antioxidant and neuroprotective molecules for pharmaceutical purposes. [ABSTRACT FROM PUBLISHER]

Published
2017
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67. The Metabolome pole of the Functional Genomics Platform of Bordeaux

Author

Deborde, Catherine, Bernillon, Stéphane, Cabasson, Cécile, Maucourt, Mickael, Renaud, Christel, Dieuaide Noubhani, Martine, Rolin, Dominique, Moing, Annick, Richard, T., Monty, J.P., Krisa, Stéphanie, Iglesias, M.L., Pedrot, E., Waffo Teguo, P., Delaunay, J.C., Mérillon, J.M., Bessoule, J.J., Moreau, P., Sargueil, F., Wattelet, V., Larroche Traineau, J., Testet, E., Lessire, Rene, Jacob, D., Ferry Dumazet, H., Barre, A., Gil, L., De Daruvar, A., ProdInra, Migration, Station de physiologie végétale, Institut National de la Recherche Agronomique (INRA), Université de Bordeaux Ségalen [Bordeaux 2], Laboratoire de biogenèse membranaire (LBM), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Montaigne, CBiB-Centre de Bioinformatique de Bordeaux, and Université Bordeaux Segalen - Bordeaux 2

Subjects
PROFIL METABOLIQUE, [SDV] Life Sciences [q-bio], BORDEAUX, BIOLOGIE VEGETALE, POLE METABOLOME, PLATE-FORME GENOMIQUE FONCTIONNELLE, [SDV]Life Sciences [q-bio], PLANTE, QUANTIFICATION, ComputingMilieux_MISCELLANEOUS, NMR, LC-MS
Abstract

National audience

Published
2006

69. Viniphenol A, a Complex Resveratrol Hexamer from Vitis vinifera Stalks: Structural Elucidation and Protective Effects against Amyloid-β-Induced Toxicity in PC12 Cells

Author

Papastamoulis, Yorgos, primary, Richard, Tristan, additional, Nassra, Merian, additional, Badoc, Alain, additional, Krisa, Stéphanie, additional, Harakat, Dominique, additional, Monti, Jean-Pierre, additional, Mérillon, Jean-Michel, additional, and Waffo-Teguo, Pierre, additional

Published
2014
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70. Airborne methyl jasmonate induces stilbene accumulation in leaves and berries of grapevine plants

Author

Larronde, F., Gaudillère, J.P., Krisa, Stéphanie, Decendit, A., Deffieux, G., Mérillon, J.M., Unité d'agronomie, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV.SA.STA]Life Sciences [q-bio]/Agricultural sciences/Sciences and technics of agriculture, [SDV.SA.STA] Life Sciences [q-bio]/Agricultural sciences/Sciences and technics of agriculture, Horticulture, ComputingMilieux_MISCELLANEOUS, Food Science
Abstract

International audience

Published
2003

72. Assessment of Antioxidant Activity and Neuroprotective Capacity on PC12 Cell Line of Frankenia thymifolia and Related Phenolic LC-MS/MS Identification.

Author

Ben Mansour, Rim, Ksouri, Wided Megdiche, Cluzet, Stéphanie, Krisa, Stéphanie, Richard, Tristan, and Ksouri, Riadh

Subjects
ANTIOXIDANT analysis, PHENOL analysis, ANTIOXIDANTS, CELL lines, GLYCOSIDES, HIGH performance liquid chromatography, LIQUID chromatography, MASS spectrometry, MEDICINAL plants, PHENOLS, PLANT roots, PHYTOCHEMICALS, PLANT anatomy, IN vitro studies
Abstract

This work aimed to investigate the richness of a Tunisian xerohalophyte Frankenia thymifolia aerial and root parts on phenolics and to evaluate the antioxidant and neuroprotective properties of this medicinal species. After fractionation using increasing and different solvent polarities, results displayed five fractions, where ethyl acetate (EtOAc) shoot and root fractions possess considerable total phenolic contents (221 and 308 mg of GAE/g of E, resp.) related to their important antioxidant activities such as ORAC (918 and 713 mg of TE/g of E), DPPH (282 and 821 mg of TE/g), and ABTS (778 and 1320 mg of TE/g) tests. Then, the identification of the main compounds by HPLC-DAD-ESI-MS and neuroprotective property of the most active fraction EtOAc were assessed. A total of 14 molecules were identified, which have been described for the first time in F. thymifolia. The major compounds identified were pinoresinol and kaempferol glycoside in aerial parts and gallic acid and ellagitannin in roots. Neuroprotective capacity against β-amyloid (Aβ) peptide induced toxicity in PC12 cells of EtOAc fraction showed a significant protective activity at lower concentration (25 and 50 µM). The relevant antioxidant and neuroprotective activities of F. thymifolia EtOAc fraction corroborated their chemical compositions. [ABSTRACT FROM AUTHOR]

Published
2016
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76. Crystal Structure of Moracin M

Author

KAPCHE, Gilbert Deccaux, primary, WAFFO-TEGUO, Pierre, additional, MASSIP, Stéphane, additional, GUILLON, Jean, additional, VITRAC, Caroline, additional, KRISA, Stéphanie, additional, NGADJUI, Bonaventure, additional, and MERILLON, Jean-Michel, additional

Published
2007
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92. Viniphenol A, a Complex Resveratrol Hexamer from Vitis viniferaStalks: Structural Elucidation and Protective Effects against Amyloid-β-Induced Toxicity in PC12 Cells

Author

Papastamoulis, Yorgos, Richard, Tristan, Nassra, Merian, Badoc, Alain, Krisa, Stéphanie, Harakat, Dominique, Monti, Jean-Pierre, Mérillon, Jean-Michel, and Waffo-Teguo, Pierre

Abstract

Stilbenes have received much attention during the last two decades following the discovery of resveratrol in wine. Since then, there have been a growing number of papers reporting various biological activities of naturally occurring stilbenes. The aim of this study was to determine new minor stilbenes from Vitis viniferastalks. Purification of these compounds was achieved by means of centrifugal partition chromatography, a versatile separation technique that does not require a solid stationary phase. Viniphenol A (1), a new resveratrol hexamer, was isolated along with five oligostilbenoids identified in V. viniferafor the first time, ampelopsin C, davidiol A, leachianol F, leachianol G, and E-maackin, a dimer with an unusual dioxane moiety, and 14 known hydroxystilbenes. The structure and stereochemistry of viniphenol A were determined on the basis of spectroscopic data analysis and molecular modeling under NMR constraints. Viniphenol A showed protective effects against amyloid-β-induced toxicity in PC12 cell cultures.

Published
2014
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93. Obtaining Vitis Viniferacell cultures producing higher amounts of malvidin-3-O-β-glucoside

Author

Krisa, Stéphanie, Vitrac, Xavier, Decendit, Alain, Larronde, Fabienne, Deffieux, Gérard, and Mérillon, Jean-Michel

Abstract

To obtain a cell line of Vitis vinifera producing mainly malvidin-3-O-β-glucoside, three methods were studied: the initiation of new cell cultures from different varieties, the modification of phytohormones in the culture media of a high anthocyanin-producing cell line, and the selection by small-aggregate cloning of new cell lines from this high producing strain. The latter technique gave a cell line accumulating a malvidin-3-O-β-glucoside proportion of 63%.

Published
1999
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95. Arundinosides A-G, new glucosyloxybenzyl 2R-benzylmalate derivatives from the aerial parts of Arundina graminifolia.

Author

Auberon, Florence, Olatunji, Opeyemi Joshua, Krisa, Stéphanie, Herbette, Gaëtan, Antheaume, Cyril, Bonté, Frédéric, Mérillon, Jean-Michel, and Lobstein, Annelise

Subjects
*AMYLOIDOSIS, *ALTERNATIVE medicine, *ANIMAL experimentation, *BIOLOGICAL models, *MEDICINAL plants, *NEURONS, *NUCLEAR magnetic resonance spectroscopy, *RATS, *PLANT extracts, *PLANT anatomy, *IN vitro studies, *PREVENTION
Abstract

Seven new glucosyloxybenzyl 2 R -benzylmalate derivatives, arundinosides A-G ( 1 – 7 ) were isolated from the aerial parts of the bamboo orchid Arundina graminifolia . This is the first occurrence of this class of compounds in the genus Arundina . Their planar structures and absolute configuration were determined by extensive NMR spectroscopic data as well as chemical conversion. Their neuroprotective properties were also evaluated on their potential ability to reduce the beta amyloid damage on PC12 cell model. [ABSTRACT FROM AUTHOR]

Published
2018
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99. Malvidin-3-O-? glucoside, major grape anthocyanin, inhibits human macrophage-derived inflammatory mediators and decreases clinical scores in arthritic rats.

Author

Decendit, Alain, Mamani-Matsuda, Maria, Aumont, Virginie, Waffo-Teguo, Pierre, Moynet, Daniel, Boniface, Katia, Richard, Emmanuel, Krisa, Stéphanie, Rambert, Jérôme, Mérillon, Jean-Michel, and Mossalayi, M.D.

Subjects
*GLUCOSIDES, *ENOCYANIN, *MACROPHAGES, *INFLAMMATORY mediators, *TREATMENT of arthritis, *ANTHOCYANINS, *LABORATORY rats
Abstract

Abstract: Polyphenolic anthocyanins are major colorful compounds in red fruits, known to prevent cardiovascular and other diseases. Grape polyphenols are a mixture of various molecules and their exact contribution to above bioactivities remains to be clarified. In the present study, we first analyzed the effect of purified grape-derived compounds on human peripheral blood mononuclear cell (PBMC) survival, proliferation, as well as for their ability to inhibit the activation of human normal macrophages. Data indicated that malvidin-3-O-? glucoside (Mal?g), the major grape anthocyanin, is bioactive with no toxicity on human PBMC. Mal?g decreased the transcription of genes encoding inflammatory mediators, confirmed by the inhibition of TNF?, IL1, IL-6 and iNOS-derived nitric oxide (NO) secretion from activated macrophages. As Mal?g also inhibited inflammatory response of rat macrophages, we investigated the anti-inflammatory potential of Mal?g in chronic rat adjuvant-induced arthritis (AIA). Mal?g significantly diminished inflammatory cachexia and arthritic paw scores in AIA rats at both therapeutic and preventive levels. In vivo effects of Mal?g correlated with down-regulation of NO generation from AIA rats’ peritoneal macrophages ex vivo. These data indicate that Mal?g, major grape anthocyanin, is a potent anti-inflammatory agent in vitro and in vivo, without detectable toxic effect. [Copyright &y& Elsevier]

Published
2013
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100. Production of highly 13C-labeled polyphenols in Vitis vinifera cell bioreactor cultures.

Author

Aumont, Virginie, Larronde, Fabienne, Richard, Tristan, Budzinski, Hélène, Decendit, Alain, Deffieux, Gérard, Krisa, Stéphanie, and Mérillon, Jean-Michel

Subjects
*BIOREACTORS, *CELL growth, *BACTERIA, *METABOLISM, *POLYPHENOLS
Abstract

The use of Vitis vinifera cells grown in a 2 l-stirred tank bioreactor for producing isotopically 13C-labeled phenolic substances is presented. Several culture parameters were optimized to achieve characteristics of growth and polyphenol metabolism similar to that recorded in shake flasks. Administration of [1-13C]L-phenylalanine (3 mM) to grape cell suspension cultures led to the production of 13C-labeled stilbenes (trans- and cis-piceids), catechins (catechin and epicatechin) and anthocyanins (delphinidin-, cyanidin-, petunidin-, peonidin- and malvidin-3-O-β-glucosides). Incorporation of [1-13C]L-phenylalanine into polyphenols was measured by means of 13C satellites in the proton NMR spectrum and EA-IRMS. The enrichment of labeling obtained for all the compounds (between 40 and 65%) is sufficient to investigate their absorption and metabolism in humans. [Copyright &y& Elsevier]

Published
2004
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