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1,094 results on '"Kraft K"'

51. Patterns of [p21.sup.waf1/cip1] expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas. (Papers)

Author

Schwerer, M J., Sailer, A, Kraft, K, Baczako, K, and Maier, H

Subjects
Nasal mucosa -- Analysis -- Genetic aspects, Tumor suppressor genes -- Analysis -- Genetic aspects, Squamous cell carcinoma -- Genetic aspects, Health, Analysis, Genetic aspects
Abstract

Abstract Aims--To clarify [p21.sup.waf1/cip1] expression in sinonasal lesions. Methods--Archived surgical specimens from 38 patients were investigated by means of immunohistochemistry. [p21.sup.waf1/cip1] staining was evaluated in the different layers of the [...]

Published
2001

61. STW 5 in 1515 patients with functional gastrointestinal diseases

Author

Möller, J, additional, Raskopf, E, additional, Greinert, O, additional, Zadoyan, G, additional, Schleicher, S, additional, Shah-Hosseini, K, additional, Wegener, T, additional, Kelber, O, additional, Singh, J, additional, Kraft, K, additional, Nieber, K, additional, and Mösges, R, additional

Published
2019
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81. Living long and well: prospects for a personalized approach to the medicine of ageing

Author

Fuellen G., Schofield P., Flatt Thomas, Schulz R.-J., Boege F., Kraft K., Rimbach G., Ibrahim S., Tietz A., Schmidt C., Köhling R., Simm A., Fuellen G., Schofield P., Flatt Thomas, Schulz R.-J., Boege F., Kraft K., Rimbach G., Ibrahim S., Tietz A., Schmidt C., Köhling R., and Simm A.

Abstract

Research into ageing and its underlying molecular basis enables us to develop and implement targeted interventions to ameliorate or cure its consequences. However, the efficacy of interventions often differs widely between individuals, suggesting that populations should be stratified or even individualized. Large-scale cohort studies in humans, similar systematic studies in model organisms as well as detailed investigations into the biology of ageing can provide individual validated biomarkers and mechanisms, leading to recommendations for targeted interventions. Human cohort studies are already ongoing, and they can be supplemented by in silico simulations. Systematic studies in animal models are made possible by the use of inbred strains or genetic reference populations of mice. Combining the two, a comprehensive picture of the various determinants of ageing and ‘health span' can be studied in detail, and an appreciation of the relevance of results from model organisms to humans is emerging. The interactions between genotype and environment, particularly the psychosocial environment, are poorly studied in both humans and model organisms, presenting serious challenges to any approach to a personalized medicine of ageing. To increase the success of preventive interventions, we argue that there is a pressing need for an individualized evaluation of interventions such as physical exercise, nutrition, nutraceuticals and calorie restriction mimetics as well as psychosocial and environmental factors, separately and in combination. The expected extension of the health span enables us to refocus health care spending on individual prevention, starting in late adulthood, and on the brief period of morbidity at very old age

Published
2019

89. Dynamic 3D chromatin architecture determines enhancer specificity and morphogenetic identity in limb development

Author

Kragesteen , B., Spielmann, M., Paliou, C., Heinrich, V., Schöpflin, R., Esposito, A., Annunziatella, C., Bianco , S., Chiariello, A., Jerković , I., Harabula, I., Guckelberger, P., Pechstein, M., Wittler, L., Chan, W., Franke, M., Lupiáñez , D., Kraft, K., Timmermann, B., Vingron, M., Visel, A., Nicodemi, M., Mundlos, S., and Andrey, G.

Subjects
animal structures
Abstract

The regulatory specificity of enhancers and their interaction with gene promoters is thought to be controlled by their sequence and the binding of transcription factors. By studying Pitx1, a regulator of hindlimb development, we show that dynamic changes in chromatin conformation can restrict the activity of enhancers. Inconsistent with its hindlimb-restricted expression, Pitx1 is controlled by an enhancer (Pen) that shows activity in forelimbs and hindlimbs. By Capture Hi-C and three-dimensional modeling of the locus, we demonstrate that forelimbs and hindlimbs have fundamentally different chromatin configurations, whereby Pen and Pitx1 interact in hindlimbs and are physically separated in forelimbs. Structural variants can convert the inactive into the active conformation, thereby inducing Pitx1 misexpression in forelimbs, causing partial arm-to-leg transformation in mice and humans. Thus, tissue-specific three-dimensional chromatin conformation can contribute to enhancer activity and specificity in vivo and its disturbance can result in gene misexpression and disease.

Published
2018

100. Entwicklung eines neuen Moduls für das TraumaRegister DGU®: Folgen schwerer Verletzungen während der Schwangerschaft besser erfassen.

Author

Trentzsch, H., Weißleder, A., Annecke, T., Beinkofer, D., Beese, A., Kulla, M., Kraft, K., Pecks, U., Hoffmann, F., and Bieler, D.

Abstract

Copyright of Der Unfallchirurg is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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