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The hunting tourism product is based on various hunting game and other types of services (accommodation, food, transport, educational services, cultural and recreational activities). This study reveals four factors that influence choosing a hunting destination and satisfaction with consuming tourism services. The study aimed to analyze the relationship between hunting tourism products quality and overall tourist satisfaction and to examine the measurement model for hunting tourists’ satisfaction. This scale focuses on specific elements of hunting tourism products and contributes to a better understanding of the quality of hunting tourism offers. Using the CFA, the reliability and validity of the hunting tourism satisfaction scale (HUNTSS) were confirmed on the sample in Serbia, and this scale was validated as a reliable four-factor model which could be assessed for future research improvements. Results of SEM showed the influences of four factors of hunting tourism products on overall satisfaction.

This paper deals with the criteria based on which the conjunction док is classified as a coordinating or subordinating conjunction in contrast clauses. This paper was occasioned by the one written by D. Klikovac (2022) published in Јужнословенски филолог (vol. LXXVIII, no. 1), in which the application of pseudo-scientific criteria brought into question the exact syntactic criteria according to which the conjunction док is classified exclusively as a subordinating conjunction. This paper presents a detailed and criteria-based analysis of all the arguments that the author provided in order to prove that the conjunction док in complex contrast sentences does not belong to the subordinating, but to the coordinating conjunctions. The detailed analysis of each of the arguments given by the author with a view to refuting the subordinating status of the contrastive conjunction док showed that none of those criteria has the status of the sufficient reason for classifying this conjunction as a coordinating one. This paper confirmed the scientific findings that the contrastive conjunction док shares all the features of the subordinating conjunctions, which are the following: a) it introduces the clause structure it belongs to into the complex sentence, b) introduces only dependent clauses, c) contrast док-clauses can be condensed into prepositional case constructions functioning as an adverbial. None of those features is shared by any coordinating conjunction.

Digital entrepreneurship represents an important component of economic development. This paper tries to emphasize the importance of the factors that belong to the digital dimension of the entrepreneurial ecosystem according to the EIDES methodology, in the early phase of the company's life cycle, from the area of human capital. The goal is to point out the role of these factors in improving economic stability and the ability of individuals to effectively respond to the challenges and opportunities of the modern digital environment. Understanding the importance of this dimension becomes crucial when defining policies and strategies aimed at improving the quality of life of individuals and the social community as a whole, ensuring fair access to economic and professional opportunities of importance for social security in the 21st century.

Typha latifolia (cattail) forms natural stands in the transition zone of artificial flotation and mine tailings ponds and is contaminated with extremely high concentrations of metals. We assessed the absorption capacity of the plant, metal transfer to leaves, and the effects of elevated metal concentrations on antioxidant enzyme activities. Soil acidity, the pseudototal and available metal content of the substrate, and metal concentrations in plants were examined. The effects of elevated metal concentrations in plants on antioxidant enzyme activities (superoxide dismutase, catalase, ascorbate peroxidase, guaiacol peroxidase, glutathione reductase) were assessed. Cattails exhibited high metal accumulation levels in roots and a low transfer rate to the leaves. The effects of metal concentrations on antioxidant enzyme activities were found to depend on the type of enzyme, metal concentrations in the plant and their molar ratios, as well as on the pH of the substrate. High activities of antioxidant enzymes indicate increased generation of reactive oxygen species (ROS) and show that metal detoxification mechanisms are insufficient to restrain their toxicity. Pronounced resistance to elevated metal concentrations and high efficiency in metal phytostabilization show that cattail could be a valuable component of biological treatment systems for removing metals from multi-metal and heavily contaminated substrates in the pH range from ultra-acidic to neutral.

Decades of mining activity have resulted in the accumulation of significant amounts of tailings that are deposited over the natural vegetation, forming deposits tens of meters thick. The tailings are poor in organic matter and macronutrients and contain a high concentration of potentially toxic elements (PTE). Their surface remains unvegetated for long periods of time and is susceptible to fluvial and wind erosion. Equisetum arvense and E. telmateia appear to be the first colonizers in the tailings of the Pb–Cu–Zn mine in Serbia. Each plant was sampled along with its associated substrate. Pseudototal and available metals in the substrate, as well as total As, Cd, Cu, Fe, Mn, Ni, Pb and Zn concentrations in the plant parts were determined by atomic absorption spectrophotometry. The findings show that both species have high bioaccumulation capacity and tolerance to otherwise toxic concentrations due to efficient accumulation, immobilization and detoxification of these elements in their underground parts. It is expected that the long-term presence of metal-tolerant horsetail species would increase the organic matter content of flotation residues, thus gradually improving their physical, chemical and biological properties. This, in turn, would promote the natural succession of other metaltolerant plant species and soil microorganisms.

Different types of communication enable an intensive exchange of diverse ideas and content, thereby enabling the development and enrichment of human thought. On the other hand, modern forms of communication additionally increase the risk of violation and endangerment of human rights and freedoms by those who use hate speech. Hence, many international documents are dedicated to defining and preventing hate speech, while various international institutions, including the European Court of Human Rights, try to determine the criteria under which certain restrictions on freedom of speech could be acceptable. Bearing in mind the above, the author has analyzed the cases from the practice of the European Court of Human Rights in order to distinguish the standards which could be applicable in the process of assessment if certain expressions constitute hate speech that should be sanctioned, and also to establish to what extent such standards are applicable in different situations. The author concludes that the formulated standards do have a certain utility value, but that there is still a risk of extensive restriction of freedom of speech.

The creation of franchise companies has a lasting and positive impact on the economies of the countries and local communities in which they operate. Countless jobs are created and supported by franchises, and those jobs help lower the unemployment rate. Franchises support the national GDP through billions of dollars in products and services, and job creation. The 2008-2010 recession, as well as the pandemic, had a negative impact on the US and global economy, although franchises fared better than most other retail chains and small businesses. The subject of research in the paper is the analysis of the basic characteristics and features of franchising, with the aim of drawing attention to the use of franchise in business on domestic and international markets, to point out the specifics of business and its ways of functioning, to point out the advantages, disadvantages, and wider significance of franchise business, on the existence of the attractiveness index of a country for franchise investments. Research results indicate that franchises are economically more stable, mainly due to their branding, consumer familiarity, and strong network base. It is estimated that franchises will operate better, more intensively and more diversely in the coming period.

The validity of a will is conditioned by the existence of the testamentary capacity at the time of its creation, existence of certain qualities regarding the testator's will, as well as the the requirement that the will of the testator must be expressed in the form and under the conditions provided by law. The aticle primarily focuses on certain substantive legal assumptions of the validity of will, as well as on formal legal assumptions of its validity, specifically, on the testamentary capacity and forms of will, and the prescribed form requirements regarding existing forms of will, i.e. the conditions under which they can be made. By analyzing the current statutory provisions that are dedicated to the mentioned issues, from the point of view of the ruling doctrinal positions, as well as legal solutions accepted in other countries, certain deficiencies are identified in their legislation as well as in the application of these solutions in legal practice. In the paper, the authors propose the necessary changes and supplements in order to obtain a higher quality, as well as a more comprehensive way of regulating the analyzed institutes in the domain of the testamentary inheritance.

In recent decades, special attention has been devoted to the protection and improvement of the environment, and efforts are being made to adopt and implement appropriate laws, regulations, measures, etc. Due to the fact that the right to a healthy environment is one of the basic human rights, the subject of research in the paper is an analysis of the concept, principles and instruments of environmental protection, with the aim of pointing out the basic principles and postulates, as well as bringing the level of competitiveness into relation countries with regulations in this area. The research showed that the principles in the field of environmental protection and their systematization represent the basis and that further improvement is necessary. It is necessary to become aware of the responsibility of individuals and society as a whole and work to overcome the interests of individuals.

Introduction/Objective. The optimal percutaneous coronary intervention (PCI) in patients with non-STelevated myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) is still not clear. The aim of our study was to examine intrahospital and long-term major adverse cardiovascular and cerebrovascular events (MACCE) in this group of patients. Methods. This retrospective study included 225 patients with NSTEMI and multivessel CAD treated with PCI at the Institute of Cardiovascular Diseases of Vojvodina. Three groups were formed: complete one-stage PCI; complete multi-stage PCI, and culprit-only PCI. We analyzed intrahospital and one-year follow-up MACCE and mortality after three years in all three groups. Results. Complete one-stage PCI was performed in 112 (49.8%), complete multi-stage PCI in 70 (31.3%), and culprit-only PCI in 43 (19.1%) patients. Patients with multi-stage complete PCI had the lowest mortality in comparison with one-stage and culprit-only PCI, both intrahospital (0% vs. 0.9% and 20.9%, respectively, p < 0.0005) and after one year (0% vs. 2.7% and 30.2%, respectively, p < 0.0005) and three years (4.3% vs. 5.4% and 32.6%, respectively, p < 0.0005). There was no significant difference in other MACCE between the groups, both intrahospital and after one year. Conclusion. In our study, multi-stage PCI significantly reduces intrahospital, one-year and three-year follow-up mortality in patients with NSTEMI and multivessel CAD.

Background: The study aimed to estimate lidocaine (LID) pharmacokinetic parameter values in patients with impaired liver function, level of correlation between the pharmacokinetic parameters and Child-Pugh class and change in pharmacokinetic parameters after liver tumor resection compared to the preoperative value. Methods: Patients with impaired liver function were subject to the LID test 1 day prior to, 3 and 7 days after the intervention. LID was administered in single i.v. dose of 1 mg/kg. Blood samples were collected at 15, 30 and 90 minutes after drug administration. Non-compartmental analysis was applied for calculating the pharmacokinetic parameters. Results: The study included 17 patients with the diagnosis of cirrhosis and 41 patients with liver tumor. In both groups of patients, the values of the coefficients of correlation show the best correlation between clearance (CL) and Child-Pugh score (-0.693, p

Preparation of photocatalytically active ZnO layer by chemical bath deposition was investigated. Layers of layered basic zinc acetate (LBZA) were successfully deposited on substrates of varying morphologies, and the substrate hydrolysis led to formation of thicker and better adhering layers. However, the process was quite sensitive to variations in conditions, which makes coating of larger surfaces more challenging. Photocatalytic activity of ZnO layers obtained from LBZA by calcining had poor reproducibility, varying up to 50 % without obvious regularity. [ABSTRACT FROM AUTHOR]

The right to education, as one of the rights inherent to all human beings, necessarily implies an educational process that takes place in an institution that does not tolerate discrimination or hate speech. During the previous decades, both at the European and global level, relevant standards have been established in order to obtain an educational system that adequately opposes the phenomenon of discrimination, while nurturing a climate and culture conducive to the full development of students' personal potential. Having in mind the importance of preventing discrimination and hate speech in educational context, the authors have conducted a study aimed at the comparative analysis of the international and Serbian anti-discriminatory regulatory framework in the educational settings. Normative-dogmatic and comparative methods have been applied, with the focus on the systematic interpretation of the meaning and content of the studied norms. The key results of the research indicate that the domestic national framework corresponds with the relevant international standards. However, national regulations, contrary to internationally accepted paradigms, do not pay adequate attention to the intercultural elements of the educational process, because they are focused on prohibitions and post festum interventions on discrimination and hate speech.

Background/Aim. Health professions education is facing emerging issues. A comprehensive situation analysis was performed among academic staff, healthcare practitioners, and healthcare science students to address and respond to new trends. The aim of the study was to investigate the attitude, perception, and the recognized needs towards experiential education (EE), interprofessional education (IPE), and teaching competencies development (TCD). The critical evaluation of the existing quality standards for further quality improvement in health professions education in Serbia was provided. Methods. The survey on EE, IPE, and TCD was conducted within the Reinforcement of the Framework for Experiential Education in Serbia (ReFEEHS) project, co-funded by the Erasmus+ program of the European Comission at four Serbian universities (the University of Belgrade, the University of Kragujevac, the University of Niš, and the University of Novi Sad). Four task groups were appointed to perform a desk review of the existing curricula, recommendations, and practices within each of the four health professions education (Medicine, Pharmacy, Dentistry, and Nursing) in Serbia and assess the level of compliance with relevant educational policies and practices in the European Union. Results. A total of 1,507 respondents completed the survey. A highly expressed positive attitude was found towards EE, IPE, and TCD among all the respondents. The majority of the respondents (> 70%) shared that EE should be organized in real-life practice and involve students’ work under the supervision of a qualified supervisor, as well as interactions with patients and healthcare professionals. About 90% of the respondents supported the inclusion of IPE teaching activities into EE, with 77% of students expressing high motivation to attend those classes, whereas 93% of academic staff was eager to deliver and teach joint IPE subjects. Only 20% of academic staff has already attended some TCD program, while 75% recognized the need for its organization. Moreover, 90% of healthcare practitioners have recognized that mentors/clinical supervisors also need additional skills for effective mentoring work within health science education. Based on the survey results, recommendations for improvement were given within three educational fields, healthcare science curricula, professional practice (traineeship), teaching staff, and regulations. Conclusion. The results derived from the survey served as a starting but also a vital point for higher education improvement in Serbia. All interested parties – academia, students, healthcare professionals, and regulatory bodies should collaborate on achieving improved, contemporary, and transformative health professions education.

Nowadays, the life of an individual can hardly be imagined without using the attainment of the IT system. Its vertiginous development and people's familiarity with it has led to the fact that personal data are becoming an important, if not the most important, resource today. So much so, that they are also called "the oil of new era". This is coming from the fact that companies now charge users for their mostly free services by asking them for more and more different data in return. Contrary to that, most of the users do not think about what will happen to their personal data after their death or are not aware of all the ways they can dispose of their digital assets mortis causa. The authors consider the question of heritability of digital goods, and especially the possibility of disposing of them in the event of the death of the testator. Analyzing the current domestic regulations, as well as the direction of development of digital inheritance in other European countries, at the same time the authors are trying to find an answer to the question how to understood the term of digital inheritance within the framework of our country

Thyroid dysfunction is one of the most prevalent endocrine disorders, especially common in female patients. If patients are not diagnosed in time or adequately treated, the patients' quality of life can be significantly impaired and additional health problems may occur, considering the key roles of thyroid hormones in the body. Therefore, it is necessary to raise awareness about the importance of recognition of symptoms that may indicate a potential problem with the thyroid gland and help to identify possible causes. For patients who are already being treated with levothyroxine (hypothyroidism), or thiamazole, carbimazole or propylthiouracil (hyperthyroidism), it is necessary to point out the necessity of proper, regular use of the drugs and implementation of accompanying nonpharmacological measures, as well as the potential for the occurrence of adverse reactions and interactions with other drugs or food. A significant role in the mentioned activities should be played by the pharmacist, as the most accessible member of the health team, who can, if necessary, refer the patient to a doctor for diagnosis, monitor the effectiveness and safety of the therapy, and provide appropriate patient counseling.

The traditional concept of drug discovery is based on the occupancy driven pharmacology model. It implies the development of inhibitors occupying binding sites that directly affect protein functions. Therefore, proteins that do not have such binding sites are generally considered as pharmacologically intractable. Furthermore, drugs that act in this way must be administered in dosage regimens that often result in high systemic drug exposures in order to maintain sufficient protein inhibition. Thus, there is a risk of the onset of off target binding and side effects. The landscape of drug discovery has been markedly changed since proteolysis targeting chimera (PROTAC) molecules emerged twenty years ago as a part of the event-driven pharmacology model. These are bifunctional molecules that harness the ubiquitin-proteasome system, and are composed of a ligand that binds the protein of interest (POI), a ligand that recruits E3 ubiquitin ligase (E3UL) and a linker that connects these two parts. Pharmacologically, PROTACs bring POI and E3UL into close proximity, which triggers the formation of a functional ternary complex POI– –PROTAC–E3UL. This event drives polyubiquitination and subsequent POI degradation by the 26S proteasome. The development and exceptional properties of PROTAC molecules that brought them to clinical studies will be discussed in this paper.

Background/Aim. Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) 2019 infection represents a global problem. At this moment, in October 2020, there is no vaccine or efficient treatment for infected patients. Treatment with blood plasma rich with anti-SARS-CoV-2 specific antibodies might be a safe, and effective therapy for COVID-19 patients. Methods. A total of 768 patients were analyzed in this study, whose samples were collected in a time interval from May 1, 2020, till August 15, 2020. Patients were enrolled in the study from COVID-19 hospitals and out-clinics. In-house ELISA tests were developed to measure the concentration of anti-S1S2 spike and anti-nucleoprotein (np) (IgG, IgA, IgM) SARS-CoV-2 antibodies. Blood convalescent plasma was selectively collected from recovered patients according to specific antibodies concentration. Results. The highest concentrations of anti-S1S2 spike or anti-np specific IgG antibodies were detected in patients with the moderate/heavy clinical form of the infection. An extremely high concentration of anti-S1S2 spike IgG and anti-np IgG was demonstrated in 3% and 6% of patients who recovered from severe COVID-19, respectively. Of tested hospitalized patients, 63% and 51% had modest levels of anti-S1S2 spike and anti-np, respectively. After 60 days, in our selected donors, concentrations of anti- S1S2 spike IgG and anti-np IgG antibodies increased in 67% and 58% of donors, respectively. Conclusion. In-house developed ELISA tests enable a novel protocol for selecting convalescent blood plasma donors recovered from SARS-CoV-2 infection.

Successful development of hunting tourism requires the support of a local community and positive attitudes of residents. This research aims to explore the population in the Vojvodina region (Serbia) which was well known hunting tourism destination in Europe during the '70s and '80s. The survey included a final sample of 206 respondents. This study showed that residents mostly approve of and support hunting tourism revitalization. However, they find that it needs to be implemented sustainably, according to the law, without threatening the habitat and game funds. This study also explored different predictors that shape attitudes towards hunting tourism. Results show that being a hunter, having a higher level of education, frequently having outdoor activities in nature, being interested in the topic of hunting and hunting tourism, and having a dominant meat diet lead to a more positive attitude towards hunting tourism.

Background/Aim. Determining the value of Gissane’s angle (GA) plays a role in the diagnosis and prognosis of heel fractures, determining treatment methods, and assessing the outcome of surgical treatment. Normal values of the GA vary in relation to ethnicity, age, and gender of the examined group, which indicates its anthropometric significance. The aim of this study was to determine the range of normal GA values in the population of Central Serbia. Methods. GA was determined on lateral radiography of the foot of 145 subjects of both sexes (67 women and 78 men), with subjects divided into 6 age groups. The patients included in the study did not have a calcaneus fracture. The obtained results were processed in the Graph Pad program. Results. The average value of GA in Central Serbia was 110.8° ± 8.1°, ranging from 93° to 132.9°. The mean value of GA decreased with age, and no difference was observed between women and men, except in the youngest age group, where women had higher GA values than men. Conclusion. The results of the study showed a wide range of normal GA values, as well as the existence of a difference in subjects of different ages and sex.

Introduction/Objective: Survival and neurologic recovery after out-of-hospital cardiac arrest remain poor despite significant advances in the therapeutic approach. The study aimed to evaluate predictors of intrahospital survival and neurologic outcome among patients after outof-hospital cardiac arrest as well as to evaluate the influence of mild therapeutic hypothermia introduction on intrahospital survival and neurologic outcome among comatose patients after out-of-hospital cardiac arrest. Methods The research was conducted as a retrospective observational study among patients hospitalized at the Cardiac Intensive Care Unit of the Institute for Cardiovascular Diseases of Vojvodina from January 2007 until November 2019 as a result of an out-of-hospital cardiac arrest. Results. The research included 506 survivors of OHCA. Multivariate regression analysis showed that initial shockable rhythm, cardiopulmonary resuscitation efforts lasting no longer than 20 minutes and a Glasgow Coma Score above 8 at admission, were predictors of intrahospital survival and good neurological outcome. Introduction of mild therapeutic hypothermia improved intrahospital survival (54.1% vs. 24.4%; p < 0.0005) and neurological outcome (42.9% vs. 18.3%; p < 0.0005) in comatose patients with initial shockable rhythm. Conclusion. In our study group of out-of-hospital cardiac arrest patients, initial shockable rhythm, cardiopulmonary resuscitation efforts lasting no longer than 20min and a Glasgow Coma Score above 8 at admission were predictors of intrahospital survival and favourable neurological outcome. The introduction of mild therapeutic hypothermia significantly improved survival and neurological outcomes in comatose patients with initial shockable rhythms.

The subject of paper is a presentation of the most important models of strategic analysis of importance for business operations and strategic decision-making by managers and executives. Strategic thinking is a necessary approach to today's business management. The knowledge of the external and internal environment is of vital importance for a manager to manage the company and make strategic decisions. The starting point for strategic management is strategic analysis. The goals of the organization are met precisely thanks to strategic management. The paper explains in detail the four models of strategic analysis which are of importance for business operations and strategic decision-making, namely the SWOT analysis, PEST analysis, McKinsey analysis and the BCG matrix. Through a detailed content analysis, we tried to show all stakeholders, especially managers and executives, how important for them it is to know and use selected strategic analyses in business and encourage the aforementioned stakeholders to use them to improve the business situation in an increasingly dynamic business environment. Adaptation to changes in the external and internal environment is possible only if strategic management is implemented. In a dynamic and constantly changing business environment, for successful decision-making, as well as for successful in business, it is necessary to use certain strategic analyses. The aim of this paper is to present the most important strategic analyses to all stakeholders, which can improve and enhance their business.