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296 results on '"Kopp, Felix"'

56. Sammelklagen, Gruppenklagen, Verbandsklagen – Bedarf es neuer Instrumente des kollektiven Rechtsschutzes im Zivilprozess?, Ergebnisse der Legal Research Group zum 72. Deutschen Juristentag (Should New Collective Action Instruments be Implemented into German Civil Procedure? – Results of the ELSA Legal Research Group to the 72th 'Deutscher Juristentag')

Author

Herold, Sophie, primary, Kehrberger, Roman F., additional, Kreuter, Shajan, additional, Kopp, Felix, additional, and Meyer, Felix, additional

Published
2018
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58. Assessment of quantification accuracy and image quality of a full‐body dual‐layer spectralCTsystem

Author

Ehn, Sebastian, primary, Sellerer, Thorsten, additional, Muenzel, Daniela, additional, Fingerle, Alexander A., additional, Kopp, Felix, additional, Duda, Manuela, additional, Mei, Kai, additional, Renger, Bernhard, additional, Herzen, Julia, additional, Dangelmaier, Julia, additional, Schwaiger, Benedikt J., additional, Sauter, Andreas, additional, Riederer, Isabelle, additional, Renz, Martin, additional, Braren, Rickmer, additional, Rummeny, Ernst J., additional, Pfeiffer, Franz, additional, and Noël, Peter B., additional

Published
2017
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59. Bone mineral density measurements in vertebral specimens and phantoms using dual-layer spectral computed tomography

Author

Mei, Kai, primary, Schwaiger, Benedikt J., additional, Kopp, Felix K., additional, Ehn, Sebastian, additional, Gersing, Alexandra S., additional, Kirschke, Jan S., additional, Muenzel, Daniela, additional, Fingerle, Alexander A., additional, Rummeny, Ernst J., additional, Pfeiffer, Franz, additional, Baum, Thomas, additional, and Noël, Peter B., additional

Published
2017
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63. Controlling Sulfuryl-Transfer

Author

Cook, Ian, Wang, Ting, Wang, Wei, Kopp, Felix, Wu, Peng, and Leyh, Thomas S.

Subjects
Models, Molecular, Receptors, Estrogen, Cell Line, Tumor, Sulfur Oxides, Humans, Sulfotransferases, Article
Abstract

In humans, the cytosolic sulfotransferases (SULTs) catalyze regiospecific transfer of the sulfuryl moiety (-SO3) from 3'-phosphoadenosine 5'-phosphosulfate to thousands of metabolites, including numerous signaling small molecules, and thus regulates their activities and half-lives. Imbalances in the in vivo set points of these reactions leads to disease. Here, with the goal of controlling sulfonation in vivo, molecular ligand-recognition principles in the SULT and nuclear receptor families are integrated in creating a strategy that can prevent sulfonation of a compound without significantly altering its receptor affinity, or inhibiting SULTS. The strategy is validated by using it to control the sulfonation and estrogen receptor (ER) activating activity of raloxifene (a US Food and Drug Administration-approved selective estrogen receptor modulator) and its derivatives. Preventing sulfonation is shown to enhance ER-activation efficacy 10(4)-fold in studies using Ishikawa cells. The strategy offers the opportunity to control sulfuryl transfer on a compound-by-compound basis, to enhance the efficacy of sulfonated drugs, and to explore the biology of sulfuryl transfer with unprecedented precision.

Published
2016

64. Effect of Low-Dose MDCT and Iterative Reconstruction on Trabecular Bone Microstructure Assessment

Author

Kopp, Felix K., Holzapfel, Konstantin, Baum, Thomas, Nasirudin, Radin A., Mei, Kai, Garcia, Eduardo G., Burgkart, Rainer, Rummeny, Ernst J., Kirschke, Jan S., and Noël, Peter B.

Subjects
lcsh:R, lcsh:Medicine, lcsh:Q, lcsh:Science
Abstract

We investigated the effects of low-dose multi detector computed tomography (MDCT) in combination with statistical iterative reconstruction algorithms on trabecular bone microstructure parameters. Twelve donated vertebrae were scanned with the routine radiation exposure used in our department (standard-dose) and a low-dose protocol. Reconstructions were performed with filtered backprojection (FBP) and maximum-likelihood based statistical iterative reconstruction (SIR). Trabecular bone microstructure parameters were assessed and statistically compared for each reconstruction. Moreover, fracture loads of the vertebrae were biomechanically determined and correlated to the assessed microstructure parameters. Trabecular bone microstructure parameters based on low-dose MDCT and SIR significantly correlated with vertebral bone strength. There was no significant difference between microstructure parameters calculated on low-dose SIR and standard-dose FBP images. However, the results revealed a strong dependency on the regularization strength applied during SIR. It was observed that stronger regularization might corrupt the microstructure analysis, because the trabecular structure is a very small detail that might get lost during the regularization process. As a consequence, the introduction of SIR for trabecular bone microstructure analysis requires a specific optimization of the regularization parameters. Moreover, in comparison to other approaches, superior noise-resolution trade-offs can be found with the proposed methods.

Published
2016

65. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia

Author

Reyna, Denis E., primary, Garner, Thomas P., additional, Lopez, Andrea, additional, Kopp, Felix, additional, Choudhary, Gaurav S., additional, Sridharan, Ashwin, additional, Narayanagari, Swathi-Rao, additional, Mitchell, Kelly, additional, Dong, Baoxia, additional, Bartholdy, Boris A., additional, Walensky, Loren D., additional, Verma, Amit, additional, Steidl, Ulrich, additional, and Gavathiotis, Evripidis, additional

Published
2017
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66. Spectral Photon-counting CT: Initial Experience with Dual–Contrast Agent K-Edge Colonography

Author

Muenzel, Daniela, primary, Bar-Ness, Daniel, additional, Roessl, Ewald, additional, Blevis, Ira, additional, Bartels, Matthias, additional, Fingerle, Alexander A., additional, Ruschke, Stefan, additional, Coulon, Philippe, additional, Daerr, Heiner, additional, Kopp, Felix K., additional, Brendel, Bernhard, additional, Thran, Axel, additional, Rokni, Michal, additional, Herzen, Julia, additional, Boussel, Loic, additional, Pfeiffer, Franz, additional, Proksa, Roland, additional, Rummeny, Ernst J., additional, Douek, Philippe, additional, and Noël, Peter B., additional

Published
2017
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72. Flexibility in Public Private Partnership : literature survey and a theoretical and practical review of concepts

Author

Kopp, Felix Richard, Reis, Ricardo César Ribeiro Ventura Ferreira, and Sarmento, Joaquim Miranda

Subjects
Ciências Sociais::Economia e Gestão [Domínio/Área Científica]
Abstract

Submitted by Isabel Gomes (itg@lisboa.ucp.pt) on 2015-10-06T13:29:50Z No. of bitstreams: 1 Master Thesis Final Version by Felix Kopp.pdf: 2534702 bytes, checksum: 45072c4ff8be4bfc133656fb90d7e3ef (MD5) Approved for entry into archive by Isabel Gomes (itg@lisboa.ucp.pt) on 2015-10-06T13:30:04Z (GMT) No. of bitstreams: 1 Master Thesis Final Version by Felix Kopp.pdf: 2534702 bytes, checksum: 45072c4ff8be4bfc133656fb90d7e3ef (MD5) Made available in DSpace on 2015-10-06T13:30:04Z (GMT). No. of bitstreams: 1 Master Thesis Final Version by Felix Kopp.pdf: 2534702 bytes, checksum: 45072c4ff8be4bfc133656fb90d7e3ef (MD5) Previous issue date: 2015-06-01

Published
2015

77. Evaluation of MR-derived CT-like images and simulated radiographs compared to conventional radiography in patients with benign and malignant bone tumors.

Author

Gersing, Alexandra S., Pfeiffer, Daniela, Kopp, Felix K., Schwaiger, Benedikt J., Knebel, Carolin, Haller, Bernhard, Noël, Peter B., Settles, Marcus, Rummeny, Ernst J., and Woertler, Klaus

Subjects
BONE tumors, RADIOGRAPHY, DIAGNOSTIC imaging, SOFT tissue injuries, TUMORS
Abstract

Objectives: To evaluate the diagnostic value of MR-derived CT-like images and simulated radiographs compared with conventional radiographs in patients with benign and malignant bone tumors.Methods: In 32 patients with a benign or malignant bone lesion (mean age 33.9 ± 18.5 years, 17 females), 3-T MR imaging was performed including a 3D T1-weighted gradient echo sequence as the basis for the CT-like images. From these, intensity-inverted MR image volumes were converted into 2D images via a forward projection to obtain simulated radiographs. Two radiologists assessed these images as well as conventional radiographs for the type of periosteal reaction, matrix mineralization and destruction pattern. Agreement between the modalities was calculated using Cohen's κ.Results: The agreement between conventional radiographs and MR-derived CT-like images in combination with simulated radiographs was substantial (periosteal reaction, κ = 0.67; destruction pattern, κ = 0.75), and the sensitivity of both modalities for the final diagnosis of the lesion (aggressive vs. nonaggressive) was high (MR-derived CT-like images, 86.2% vs. conventional radiographs, 90.0%). Additional information on soft tissue extension (MR-derived CT-like images, 21.9% vs. conventional radiographs, 12.5%; p = 0.009) and lobulation (9.4% vs. 0%; p < 0.001) was significantly more often found on MR-derived CT-like images compared with conventional radiographs.Conclusions: The assessment of the destruction patterns, periosteal reaction and distinction between aggressive and nonaggressive tumors was feasible using MR-derived CT-like images and simulated radiographs and is comparable to that of conventional radiographs. Moreover, MR-derived CT-like images provided additional information on soft tissue extension and tumor architecture.Key Points: • CT-like images and simulated radiographs can be generated from 3D MRI. • Evaluation of bone tumors is feasible with MR-derived images. • CT-like images and simulated radiographs provide additional information on bone tumors. [ABSTRACT FROM AUTHOR]

Published
2019
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85. Preparation and Reactions of Polymagnesiated Aromatics and Heteroaromatics, Functionalized Cyclopropane Carbenoids and Soluble Lanthanide Reagents

Author

Kopp, Felix

Subjects
FOS: Chemical sciences, magnesium, halogen/magnesium exchange, Grignard reaction, carbenoids, lanthanides
Abstract

A synthetic access to polymagnesiated aromatics and heteroaromatics via multiple magnesiations was developed, their reactivity towards different electrophiles was explored. A diatereoselective synthesis of functionalized cyclopropane carbenoids was developed. Soluble Lanthanide soloutions were prepared and used in the addition reactions of Grignard reagents to carbonyl compounds.

Published
2007
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