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53. The Radial Action from Probe Amplitudes to All Orders

Author

Kol, Uri, O'connell, Donal, and Telem, Ofri

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract

We extract the relativistic classical radial action from scattering amplitudes, to all orders in perturbation theory, in the probe limit. Our sources include point charges and monopoles, as well as the Schwarzschild and pure-NUT gravitational backgrounds. A characteristic relativistic effect, that scattering trajectories may wind around these sources any number of times, can be recovered when all-order amplitudes are available. We show that the amplitude for scattering a probe off a pure NUT is given by the solution of a transcendental equation involving continued fractions, and explain how to solve this equation to any desired loop order., Comment: Fixed typo in Schwarzschild scattering angle

Published
2021
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54. Classical double copy at null infinity

Author

Adamo, Tim and Kol, Uri

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology
Abstract

We give two double copy prescriptions which construct asymptotically flat solutions in gravity from asymptotically flat gauge fields. The first prescription applies to radiative fields, which are non-linear vacuum solutions determined by characteristic data at null infinity. For any two such radiative gauge fields (linear or non-linear), the characteristic data of a radiative metric, dilaton and axion is constructed by a simple `squaring' procedure, giving a classical double copy at the level of radiation fields. We demonstrate the procedure with several examples where the characteristic data can be explicitly integrated; for linear fields this also sheds light on the twistorial description of Weyl double copy. Our second prescription applies to all asymptotically flat fields at the level of their asymptotic equations of motion: we give a map between any solution of the asymptotic Maxwell equations and any solution of the asymptotic Einstein equations at null infinity. This also extends to the asymptotic charges and their duals, preserves the soft and hard sectors between gauge theory and gravity, and is related to the usual notion of double copy in scattering amplitudes., Comment: 44 pages, 2 figures. v2: additions to references and discussion

Published
2021
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55. Statistically Near-Optimal Hypothesis Selection

Author

Bousquet, Olivier, Braverman, Mark, Efremenko, Klim, Kol, Gillat, and Moran, Shay

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Computational Complexity, Computer Science - Information Theory, Mathematics - Optimization and Control
Abstract

Hypothesis Selection is a fundamental distribution learning problem where given a comparator-class $Q=\{q_1,\ldots, q_n\}$ of distributions, and a sampling access to an unknown target distribution $p$, the goal is to output a distribution $q$ such that $\mathsf{TV}(p,q)$ is close to $opt$, where $opt = \min_i\{\mathsf{TV}(p,q_i)\}$ and $\mathsf{TV}(\cdot, \cdot)$ denotes the total-variation distance. Despite the fact that this problem has been studied since the 19th century, its complexity in terms of basic resources, such as number of samples and approximation guarantees, remains unsettled (this is discussed, e.g., in the charming book by Devroye and Lugosi `00). This is in stark contrast with other (younger) learning settings, such as PAC learning, for which these complexities are well understood. We derive an optimal $2$-approximation learning strategy for the Hypothesis Selection problem, outputting $q$ such that $\mathsf{TV}(p,q) \leq2 \cdot opt + \eps$, with a (nearly) optimal sample complexity of~$\tilde O(\log n/\epsilon^2)$. This is the first algorithm that simultaneously achieves the best approximation factor and sample complexity: previously, Bousquet, Kane, and Moran (COLT `19) gave a learner achieving the optimal $2$-approximation, but with an exponentially worse sample complexity of $\tilde O(\sqrt{n}/\epsilon^{2.5})$, and Yatracos~(Annals of Statistics `85) gave a learner with optimal sample complexity of $O(\log n /\epsilon^2)$ but with a sub-optimal approximation factor of $3$., Comment: Accepted to FOCS 2021

Published
2021

58. Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils.

Author

Janyce A Sugui, H Stanley Kim, Kol A Zarember, Yun C Chang, John I Gallin, Willian C Nierman, and Kyung J Kwon-Chung

Subjects
Medicine, Science
Abstract

BackgroundAspergillus fumigatus is the most common etiologic agent of invasive aspergillosis in immunocompromised patients. Several studies have addressed the mechanism involved in host defense but only few have investigated the pathogen's response to attack by the host cells. To our knowledge, this is the first study that investigates the genes differentially expressed in conidia vs hyphae of A. fumigatus in response to neutrophils from healthy donors as well as from those with chronic granulomatous disease (CGD) which are defective in the production of reactive oxygen species.Methodology/principal findingsTranscriptional profiles of conidia and hyphae exposed to neutrophils, either from normal donors or from CGD patients, were obtained by using the genome-wide microarray. Upon exposure to either normal or CGD neutrophils, 244 genes were up-regulated in conidia but not in hyphae. Several of these genes are involved in the degradation of fatty acids, peroxisome function and the glyoxylate cycle which suggests that conidia exposed to neutrophils reprogram their metabolism to adjust to the host environment. In addition, the mRNA levels of four genes encoding proteins putatively involved in iron/copper assimilation were found to be higher in conidia and hyphae exposed to normal neutrophils compared to those exposed to CGD neutrophils. Deletants in several of the differentially expressed genes showed phenotypes related to the proposed functions, i.e. deletants of genes involved in fatty acid catabolism showed defective growth on fatty acids and the deletants of iron/copper assimilation showed higher sensitivity to the oxidative agent menadione. None of these deletants, however, showed reduced resistance to neutrophil attack.ConclusionThis work reveals the complex response of the fungus to leukocytes, one of the major host factors involved in antifungal defense, and identifies fungal genes that may be involved in establishing or prolonging infections in humans.

Published
2008
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61. The reported impact of non-communicable disease investment cases in 13 countries

Author

Alexey Kulikov, Douglas Webb, Dudley Tarlton, Toker Ergüder, Henrik Khachatryan, Nicholas Banatvala, Anna Kontsevaya, Bekir Keskinkilic, John Juliard Go, Diana Andreasyan, Roy Small, Aliina Altymysheva, Giuseppe Troisi, Roman Chestnov, Erwin Arthur Phillips, Taraleen Malcolm, Hero Kol, Nargiza Khodjaeva, Mussie Gebremichael, Addisu Worku Tessema, Asmamaw Bezabeh Workneh, Tamu Davidson, Michelle Harris, Nurgul Ibraeva, Aigul Nurmatova, Krisada Hanbunjerd, Sushera Bunluesin, Olivia Nieveras, Banu Ekinci, Oyoo Charles Akiya, Hafisa Kasule, Aidah Nakanjako, Shukhrat Shukurov, Nazokat Kasymova, Patrick Banda, Ernest Kakoma, Nathan N Bakyaita, Nadia Putoud, and Scott Chiossi

Subjects
Medicine (General), R5-920, Infectious and parasitic diseases, RC109-216
Abstract

Non-communicable diseases (NCDs) are a leading health and development challenge worldwide. Since 2015, WHO and the United Nations Development Programme have provided support to governments to develop national NCD investment cases to describe the socioeconomic dimensions of NCDs. To assess the impact of the investment cases, semistructured interviews and a structured process for gathering written feedback were conducted between July and October 2022 with key informants in 13 countries who had developed a national NCD investment case between 2015 and 2020. Investment cases describe: (1) the social and economic costs of NCDs, including their distribution and projections over time; (2) priority areas for scaled up action; (3) the cost and returns from investing in WHO-recommended measures to prevent and manage NCDs; and (4) the political dimensions of NCD responses. While no country had implemented all the recommendations set out in their investment case reports, actions and policy changes attributable to the investment cases were identified, across (1) governance; (2) financing; and (3) health service access and delivery. The pathways of these changes included: (1) stronger collaboration across government ministries and partners; (2) advocacy for NCD prevention and control; (3) grounding efforts in nationally owned data and evidence; (4) developing mutually embraced ‘language’ across health and finance; and (5) elevating the priority accorded to NCDs, by framing action as an investment rather than a cost. The assessment also identified barriers to progress on the investment case implementation, including the influence of some private sector entities on sectors other than health, the impact of the COVID-19 pandemic, and changes in senior political and technical government officials. The results suggest that national NCD investment cases can significantly contribute to catalysing the prevention and control of NCDs through strengthening governance, financing, and health service access and delivery.

Published
2024
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62. The radial action from probe amplitudes to all orders

Author

Kol, Uri, O’Connell, Donal, and Telem, Ofri

Subjects
Mathematical Physics, Particle and High Energy Physics, Mathematical Sciences, Physical Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Mathematical physics, Nuclear and plasma physics, Particle and high energy physics
Abstract

Abstract : We extract the relativistic classical radial action from scattering amplitudes, to all orders in perturbation theory, in the probe limit. Our sources include point charges and monopoles, as well as the Schwarzschild and pure-NUT gravitational backgrounds. A characteristic relativistic effect, that scattering trajectories may wind around these sources any number of times, can be recovered when all-order amplitudes are available. We show that the amplitude for scattering a probe off a pure NUT is given by the solution of a transcendental equation involving continued fractions, and explain how to solve this equation to any desired loop order.

Published
2022

63. Natural dynamical reduction of the three-body problem

Author

Kol, Barak

Subjects
Astrophysics - Earth and Planetary Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Theory, Physics - Classical Physics
Abstract

The three-body problem is a fundamental long-standing open problem, with applications in all branches of physics, including astrophysics, nuclear physics and particle physics. In general, conserved quantities allow to reduce the formulation of a mechanical problem to fewer degrees of freedom, a process known as dynamical reduction. However, extant reductions are either non-general, or hide the problem's symmetry or include unexplained definitions. This paper presents a dynamical reduction that avoids these issues, and hence is general and natural. Any three-body configuration defines a triangle, and its orientation in space. Accordingly, we decompose the dynamical variables into the geometry (shape + size) and orientation of the triangle. The geometry variables are shown to describe the motion of an abstract point in a curved 3d space, subject to a potential-derived force and a magnetic-like force with a monopole charge. The orientation variables are shown to obey a dynamics analogous to the Euler equations for a rotating rigid body, only here the moments of inertia depend on the geometry variables, rather than being constant. The reduction rests on a novel symmetric solution to the center of mass constraint inspired by Lagrange's solution to the cubic. The formulation of the orientation variables is novel and rests on a little known generalization of the Euler-Lagrange equations to non-coordinate velocities. Applications to global features, to the statistical solution and to special exact solutions are presented. A generalization to the four-body problem is presented., Comment: 32 pages, 2 figures. v2: added the sections "Hill-like region in geometry space" and "quotes from previous works", and made more minor changes. v3: published version + added relevant reference for Hill-like region

Published
2021
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64. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

Author

Abrough, Fekri, Acharya, Subhash P, Amin, Pravin, Arabi, Yaseen, Aragao, Irene, Bauer, Philippe, Beduneau, Gaëtan, Beitler, Jeremy, Berkius, Johan, Bugedo, Guillermo, Camporota, Luigi, Cerny, Vladimir, Cho, Young-Jae, Clarkson, Kevin, Estenssoro, Elisa, Goligher, Ewan, Grasselli, Giacomo, Gritsan, Alexey, Hashemian, Seyed Mohammadreza, Hermans, Greet, Heunks, Leo M, Jovanovic, Bojan, Kurahashi, Kiyoyasu, Laake, Jon Henrik, Matamis, Dimitrios, Moerer, Onnen, Molnar, Zsolt, Ozyilmaz, Ezgi, Panka, Bernardo, Papali, Alfred, Peñuelas, Óscar, Perbet, Sébastien, Piquilloud, Lise, Qiu, Haibo, Razek, Assem Abdel, Rittayamai, Nuttapol, Roldan, Rollin, Serpa Neto, Ary, Szuldrzynski, Konstanty, Talmor, Daniel, Tomescu, Dana, Van Haren, Frank, Villagomez, Asisclo, Zeggwagh, Amine Ali, Abe, Toshikazu, Aboshady, Abdelrhman, Acampo-de Jong, Melanie, Acharya, Subhash, Adderley, Jane, Adiguzel, Nalan, Agrawal, Vijay Kumar, Aguilar, Gerardo, Aguirre, Gaston, Aguirre-Bermeo, Hernan, Ahlström, Björn, Akbas, Türkay, Akker, Mustafa, Al Sadeh, Ghamdan, Alamri, Sultan, Algaba, Angela, Ali, Muneeb, Aliberti, Anna, Allegue, Jose Manuel, Alvarez, Diana, Amador, Joaquin, Andersen, Finn H, Ansari, Sharique, Apichatbutr, Yutthana, Apostolopoulou, Olympia, Arellano, Daniel, Arica, Mestanza, Arikan, Huseyin, Arinaga, Koichi, Arnal, Jean-Michel, Asano, Kengo, Asín-Corrochano, Marta, Avalos Cabrera, Jesus Milagrito, Avila Fuentes, Silvia, Aydemir, Semih, Aygencel, Gulbin, Azevedo, Luciano, Bacakoglu, Feza, Badie, Julio, Baedorf Kassis, Elias, Bai, Gabriela, Balaraj, Govindan, Ballico, Bruno, Banner-Goodspeed, Valerie, Banwarie, Preveen, Barbieri, Rosella, Baronia, Arvind, Barrett, Jonathan, Barrot, Loïc, Barrueco-Francioni, Jesus Emilio, Barry, Jeffrey, Bawangade, Harshal, Beavis, Sarah, Beck, Eduardo, Beehre, Nina, Belenguer Muncharaz, Alberto, Bellani, Giacomo, Belliato, Mirko, Bellissima, Agrippino, Beltramelli, Rodrigo, Ben Souissi, Asma, Benitez-Cano, Adela, Benlamin, Mohamed, Benslama, Abdellatif, Bento, Luis, Benvenuti, Daniela, Bernabe, Laura, Bersten, Andrew, Berta, Giacomo, Bertini, Pietro, Bertram-Ralph, Elliot, Besbes, Mohamed, Bettini, Lisandro Roberto, Beuret, Pascal, Bewley, Jeremy, Bezzi, Marco, Bhakhtiani, Lakshay, Bhandary, Rakesh, Bhowmick, Kaushik, Bihari, Shailesh, Bissett, Bernie, Blythe, David, Bocher, Simon, Boedjawan, Narain, Bojanowski, Christine M, Boni, Elisa, Boraso, Sabrina, Borelli, Massimo, Borello, Silvina, Borislavova, Margarita, Bosma, Karen J, Bottiroli, Maurizio, Boyd, Owen, Bozbay, Suha, Briva, Arturo, Brochard, Laurent, Bruel, Cédric, Bruni, Andrea, Buehner, Ulrike, Bulpa, Pierre, Burt, Karen, Buscot, Mathieu, Buttera, Stefania, Cabrera, Jorge, Caccese, Roberta, Caironi, Pietro, Canchos Gutierrez, Ivan, Canedo, Nancy, Cani, Alma, Cappellini, Iacopo, Carazo, Jesus, Cardonnet, Luis Pablo, Carpio, David, Carriedo, Demetrio, Carrillo, Ramón, Carvalho, João, Caser, Eliana, Castelli, Antonio, Castillo Quintero, Manuel, Castro, Heloisa, Catorze, Nuno, Cengiz, Melike, Cereijo, Enrique, Ceunen, Helga, Chaintoutis, Christos, Chang, Youjin, Chaparro, Gustavogcha, Chapman, Carmel, Chau, Simon, Chavez, Cecilia Eugenia, Chelazzi, Cosimo, Chelly, Jonathan, Chemouni, Frank, Chen, Kai, Chena, Ariel, Chiarandini, Paolo, Chilton, Phil, Chiumello, Davide, Chou-Lie, Yvette, Chudeau, Nicolas, Cinel, Ismail, Cinnella, Gilda, Clark, Michele, Clark, Thomas, Clementi, Stefano, Coaguila, Luis, Codecido, Alexis Jaspe, Collins, Amy, Colombo, Riccardo, Conde, Juan, Consales, Guglielmo, Cook, Tim, Coppadoro, Andrea, Cornejo, Rodrigo, Cortegiani, Andrea, Coxo, Cristina, Cracchiolo, Andrea Neville, Crespo Ramirez, Mónica, Crova, Philippe, Cruz, José, Cubattoli, Lucia, Çukurova, Zafer, Curto, Francesco, Czempik, Piotr, D'Andrea, Rocco, da Silva Ramos, Fernando, Dangers, Laurence, Danguy des Déserts, Marc, Danin, Pierre-Eric, Dantas, Fabianne, Daubin, Cédric, Dawei, Wu, de Haro, Candelaria, de Jesus Montelongo, Felipe, De Mendoza, Diego, de Pablo, Raúl, De Pascale, Gennaro, De Rosa, Silvia, Decavèle, Maxens, Declercq, Pierre-Louis, Deicas, Alberto, del Carmen Campos Moreno, María, Dellamonica, Jean, Delmas, Benjamin, Demirkiran, Oktay, Demirkiran, Hilmi, Dendane, Tarek, di Mussi, Rossella, Diakaki, Chrysi, Diaz, Anatilde, Diaz, Willy, Dikmen, Yalim, Dimoula, Aikaterini, Doble, Patricia, Doha, Nagwa, Domingos, Guilherme, Dres, Martin, Dries, David, Duggal, Abhijit, Duke, Graeme, Dunts, Pavel, Dybwik, Knut, Dykyy, Maksym, Eckert, Philippe, Efe, Serdar, Elatrous, Souheil, Elay, Gülseren, Elmaryul, Abubaker S, Elsaadany, Mohamed, Elsayed, Hany, Elsayed, Samar, Emery, Malo, Ena, Sébastien, Eng, Kevin, Englert, Joshua A, Erdogan, Elif, Ergin Ozcan, Perihan, Eroglu, Ege, Escobar, Miguel, Esen, Figen, Esen Tekeli, Arzu, Esquivel, Alejandro, Esquivel Gallegos, Helbert, Ezzouine, Hanane, Facchini, Alberto, Faheem, Mohammad, Fanelli, Vito, Farina, Maria Fernanda, Fartoukh, Muriel, Fehrle, Lutz, Feng, Feng, Feng, Yufeng, Fernandez, Irene, Fernandez, Borja, Fernandez-Rodriguez, Maria Lorena, Ferrando, Carlos, Ferreira da Silva, Maria João, Ferreruela, Mireia, Ferrier, Janet, Flamm Zamorano, Matias Jesús, Flood, Laura, Floris, Leda, Fluckiger, Martin, Forteza, Catalina, Fortunato, Antonella, Frans, Eric, Frattari, Antonella, Fredes, Sebastian, Frenzel, Tim, Fumagalli, Roberto, Furche, Mariano Andres, Fusari, Maurizio, Fysh, Edward, Galeas-Lopez, Juan Luis, Galerneau, Louis-Marie, Garcia, Analía, Garcia, María Fernanda, Garcia, Elisabet, Garcia Olivares, Pablo, Garlicki, Jaroslaw, Garnero, Aude, Garofalo, Eugenio, Gautam, Prabha, Gazenkampf, Andrey, Gelinotte, Stéphanie, Gelormini, Domenico, Ghrenassia, Etienne, Giacomucci, Angelo, Giannoni, Robert, Gigante, Andrea, Glober, Nancy, Gnesin, Paolo, Gollo, Yari, Gomaa, Dina, Gomero Paredes, Rosita, Gomes, Rui, Gomez, Raúl Alejandro, Gomez, Oscar, Gomez, Aroa, Gondim, Louise, Gonzalez, Manuel, Gonzalez, Isabel, Gonzalez-Castro, Alejandro, Gordillo Romero, Orlando, Gordo, Federico, Gouin, Philippe, Graf Santos, Jerónimo, Grainne, Rooney, Grando, Matilde, Granov Grabovica, Sanja, Grasso, Salvatore, Grasso, Rinaldo, Grimmer, Lisa, Grissom, Colin, Gu, Qing, Guan, Xiang-Dong, Guarracino, Fabio, Guasch, Neus, Guatteri, Luca, Gueret, Renaud, Guérin, Claude, Guerot, Emmanuel, Guitard, Pierre-Gildas, Gül, Fethi, Gumus, Ayca, Gurjar, Mohan, Gutierrez, Patricia, Hachimi, Abdelhamid, Hadzibegovic, Adi, Hagan, Samantha, Hammel, Clare, Han Song, Joo, Hanlon, Gabrielle, Heines, Serge, Henriksson, Johanna, Herbrecht, Jean-Etienne, Heredia Orbegoso, Gabriel Omar, Hermon, Andrew, Hernandez, Rosana, Hernandez, Carmen, Herrera, Luis, Herrera-Gutierrez, Manuel, Heunks, Leo, Hidalgo, Juan, Hill, Dianne, Holmquist, Dagmar, Homez, Marcela, Hongtao, Xia, Hormis, Anil, Horner, Daniel, Hornos, M Carmen, Hou, Meihong, House, Stacy, Housni, Brahim, Hugill, Keith, Humphreys, Sally, Humbert, Louis, Hunter, Stephanie, Hwa Young, Lee, Iezzi, Nicolas, Ilutovich, Santiago, Inal, Volkan, Innes, Richard, Ioannides, Panagiotis, Iotti, Giorgio Antonio, Ippolito, Mariachiara, Irie, Hiromasa, Iriyama, Hiroki, Itagaki, Taiga, Izura, Javier, Izza, Santiago, Jabeen, Rakhshanda, Jamaati, Hamidreza, Jamadarkhana, Sunil, Jamoussi, Amira, Jankowski, Milosz, Jaramillo, Luis Alberto, Jeon, Kyeongman, Jeong Lee, Seok, Jeswani, Deepak, Jha, Simant, Jiang, Liangyan, Jing, Chen, Jochmans, Sébastien, Johnstad, Bror Anders, Jongmin, Lee, Joret, Aurélie, Junhasavasdikul, Detajin, Jurado, Maria Teresa, Kam, Elisa, Kamohara, Hidenobu, Kane, Caroline, Kara, Iskender, Karakurt, Sait, Karnjanarachata, Cherdkiat, Kataoka, Jun, Katayama, Shinshu, Kaushik, Shuchi, Kelebek Girgin, Nermin, Kerr, Kathryn, Kerslake, Ian, Khairnar, Prakash, Khalid, Abidi, Khan, Akram, Khanna, Ashish K, Khorasanee, Reza, Kienhorst, Dieneke, Kirakli, Cenk, Knafelj, Rihard, Kol, Mark Kol, Kongpolprom, Napplika, Kopitko, Csaba, Korkmaz Ekren, Pervin, Kubisz-Pudelko, Agnieszka, Kulcsar, Zoltan, Kumasawa, Junji, Kuriyama, Akira, Kutchak, Fernanda, Labarca, Eduardo, Labat, Françoise, Laborda, César, Laca Barrera, Manuel Alberto, Lagache, Laurie, Landaverde Lopez, Antonio, Lanspa, Michael, Lascari, Valeria, Le Meur, Matthieu, Lee, Su Hwan, Lee, Young Ju, Lee, Jinwoo, Lee, Won-Yeon, Lee, Jarone, Legernaes, Terje, Leiner, Tamaas, Lemiale, Virginie, Leonor, Tiago, Lepper, Philipp M, Li, Dahuan, Li, Hongbin, Li, Oleg, Lima, Ana Raquel, Lind, Dan, Litton, Edward, Liu, Ning, Liu, Ling, Liu, Jialin, Llitjos, Jean-François, Llorente, Beatriz, Lopez, Rodolfo, Lopez, Claudia Elizabeth, Lopez Nava, Claudia, Lovazzano, Pablo, Lu, Min, Lucchese, Francesca, Lugano, Manuela, Lugo Goytia, Gustavo, Luo, Hua, Lynch, Ceri, Macheda, Sebastiano, Madrigal Robles, Victor Hugo, Maggiore, Salvatore Maurizio, Magret Iglesias, Mònica, Malaga, Peter, Mallapura Maheswarappa, Harish, Malpartida, Guillermo, Malyarchikov, Andrey, Mansson, Helena, Manzano, Anaid, Marey, Ismael, Marin, Nathalie, Marin, Maria del Carmen, Markman, Eliana, Martin, Felix, Martin, Alex, Martin Dal Gesso, Cristina, Martinez, Felipe, Martínez-Fidalgo, Conchita, Martin-Loeches, Ignacio, Mas, Arantxa, Masaaki, Sakuraya, Maseda, Emilio, Massa, Eleni, Mattsson, Anna, Maugeri, Jessica, McCredie, Victoria, McCullough, James, McGuinness, Shay, McKown, Andrew, Medve, László, Mei, Chengqing, Mellado Artigas, Ricard, Mendes, Vitor, Mervat, Mohamed Khalaf Ebraheim, Michaux, Isabelle, Mikhaeil, Michael, Milagros, Olga, Milet, Igor, Millan, Maria Teresa, Minwei, Zhang, Mirabella, Lucia, Mishra, Sanghamitra, Mistraletti, Giovanni, Mochizuki, Katsunori, Moghal, Arif, Mojoli, Francesco, Molin, Alexandre, Montiel, Raquel, Montini, Luca, Monza, Gianmario, Mora Aznar, Maria, Morakul, Sunthiti, Morales, Maria, Moreno Torres, Daniel, Morocho Tutillo, Diego Rolando, Motherway, Catherine, Mouhssine, Doumiri, Mouloudi, Eleni, Muñoz, Tapia, Munoz de Cabo, Carlos, Mustafa, Mohamed, Muthuchellappan, Radhakrishnan, Muthukrishnan, Muraleekrishnan, Muttini, Stefano, Nagata, Isao, Nahar, Dick, Nakanishi, Misuzu, Nakayama, Izumi, Namendys-Silva, Silvio Antonio, Nanchal, Rahul, Nandakumar, Sivakumar, Nasi, Alessandra, Nasir, Kamal, Navalesi, Paolo, Naz Aslam, Tayyba, Nga Phan, Thuy, Nichol, Alistair, Niiyama, Shuhei, Nikolakopoulou, Sofia, Nikolic, Elena, Nitta, Kenichi, Noc, Marko, Nonas, Stephanie, Nseir, Saad, Nur Soyturk, Ayse, Obata, Yukako, Oeckler, Richard, Oguchi, Moe, Ohshimo, Shinichiro, Oikonomou, Marina, Ojados, Agueda, Oliveira, Maria Teresa, Oliveira Filho, Wilson, Oliveri, Carlo, Olmos, Aitor, Omura, Kazuya, Orlandi, Maria Cristina, Orsenigo, Francesca, Ortiz-Ruiz De Gordoa, Laura, Ota, Kei, Ovalle Olmos, Rainier, Öveges, Nándo, Oziemski, Peter, Ozkan Kuscu, Ozlem, Pachas Alvarado, Fernando, Pagella, Gonzalo, Palaniswamy, Vijayanand, Palazon Sanchez, Eugenio Luis, Palmese, Salvatore, Pan, Guojun, Pan, Wensen, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Parekh, Ameet, Parke, Rachael, Parrilla, Francisco J, Parrilla, Dácil, Pasha, Taha, Pasin, Laura, Patão, Luis, Patel, Mayur, Patel, Grisma, Pati, Basanta Kumar, Patil, Jayaprakash, Pattnaik, Saroj, Paul, Daniel, Pavesi, Maurizio, Pavlotsky, Vanesa Alejandra, Paz, Graciela, Paz, Enrique, Pecci, Elisabetta, Pellegrini, Carlos, Peña Padilla, Andrea Gabriela, Perchiazzi, Gaetano, Pereira, Tiago, Pereira, Vera, Perez, Manuel, Perez Calvo, Cesar, Perez Cheng, Meisy, Perez Maita, Ronald, Pérez-Araos, Rodrigo, Perez-Teran, Purificación, Perez-Torres, David, Perkins, Gavin, Persona, Paolo, Petnak, Tananchai, Petrova, Marina, Pham, Tai, Philippart, François, Picetti, Edoardo, Pierucci, Elisabetta, Piervincenzi, Edoardo, Pinciroli, Riccardo, Pintado, Maria-Consuelo, Piraino, Thomas, Piras, Stephanie, Piras, Claudio, Pirompanich, Pattarin, Pisani, Luigi, Platas, Enrique, Plotnikow, Gustavo, Porras, Willy, Porta, Virginia, Portilla, Mariana, Portugal, José, Povoa, Pedro, Prat, Gwenael, Pratto, Romina, Preda, Gabriel, Prieto, Isidro, Prol-Silva, Estefania, Pugh, Richard, Qi, Yupeng, Qian, Chuanyun, Qin, Tiehe, Qu, Hongping, Quintana, Teobaldo, Quispe Sierra, Rosari, Quispe Soto, Rocio, Rabbani, Raihan, Rabee, Mohamed, Rabie, Ahmed, Rahe Pereira, Maria Augusta, Rai, Ashish, Raj Ashok, Sundar, Rajab, Mostafa, Ramdhani, Navin, Ramey, Elizabeth, Ranieri, Marco, Rathod, Darshana, Ray, Banambar, Redwanul Huq, Shihan Mahmud, Regli, Adrian, Reina, Rosa, Resano Sarmiento, Natalia, Reynaud, Faustine, Rialp, Gemma, Ricart, Pilar, Rice, Todd, Richardson, Angus, Rieder, Marcelo, Rinket, Martin, Rios, Fernando, Risso Vazquez, Alejandro, Riva, Ivano, Rivette, Monaly, Roca, Oriol, Roche-Campo, Ferran, Rodriguez, Covadonga, Rodriguez, Gabriel, Rodriguez Gonzalez, Daniel, Rodriguez Tucto, Xandra Yanina, Rogers, Angela, Romano, María Elena, Rørtveit, Linda, Rose, Alastair, Roux, Damien, Rouze, Anahita, Rubatto Birri, Paolo Nahuel, Ruilan, Wang, Ruiz Robledo, Aldana, Ruiz-Aguilar, Antonio Luis, Sadahiro, Tomohito, Saez, Ignacio, Sagardia, Judith, Saha, Rajnish, Saha, Rohit, Saiphoklang, Narongkorn, Saito, Shigeki, Salem, Maie, Sales, Gabriele, Salgado, Patricia, Samavedam, Srinivas, Sami Mebazaa, Mhamed, Samuelsson, Line, San Juan Roman, Nandyelly, Sanchez, Patricia, Sanchez-Ballesteros, Jesus, Sandoval, Yazcitk, Sani, Emanuele, Santos, Martin, Santos, Carla, Sanui, Masamitsu, Saravanabavan, Lakshmikanthcharan, Sari, Sema, Sarkany, Agnes, Sauneuf, Bertrand, Savioli, Monica, Sazak, Hilal, Scano, Riccardo, Schneider, Francis, Schortgen, Frédérique, Schultz, Marcus J, Schwarz, Gabriele Leonie, Seçkin Yücesoy, Faruk, Seely, Andrew, Seiler, Frederik, Seker Tekdos, Yasemin, Seok Chan, Kim, Serano, Luca, Serednicki, Wojciech, Setten, Mariano, Shah, Asim, Shah, Bhagyesh, Shang, You, Shanmugasundaram, Pradeep, Shapovalov, Konstantin, Shebl, Eman, Shiga, Takuya, Shime, Nobuaki, Shin, Phil, Short, Jack, Shuhua, Chen, Siddiqui, Sughrat, Silesky Jimenez, Juan Ignacio, Silva, Daniel, Silva Sales, Betania, Simons, Koen, Sjøbø, Brit Ågot, Slessor, David, Smiechowicz, Jakub, Smischney, Nathan, Smith, Paul, Smith, Tim, Smith, Mark, Snape, Sarah, Snyman, Lindi, Soetens, Filiep, Sook Hong, Kyung, Sosa Medellin, Miguel Ángel, Soto, Giovanna, Souloy, Xavier, Sousa, Elsa, Sovatzis, Stefania, Sozutek, Didem, Spadaro, Savino, Spagnoli, Marco, Spångfors, Martin, Spittle, Nick, Spivey, Mike, Stapleton, Andrew, Stefanovic, Branislava, Stephenson, Lorraine, Stevenson, Elizabeth, Strand, Kristian, Strano, Maria Teresa, Straus, Slavenka, Sun, Chenliang, Sun, Rongqing, Sundaram, Venkat, SunPark, Tai, Surlemont, Elisabeth, Sutherasan, Yuda, Szabo, Zsuzsanna, Tainter, Christopher, Takaba, Akihiro, Tallott, Mandy, Tamasato, Tamasato, Tang, Zhanhong, Tangsujaritvijit, Viratch, Taniguchi, Leandro, Taniguchi, Daisuke, Tarantino, Fabio, Teerapuncharoen, Krittika, Temprano, Susana, Terragni, Pierpaolo, Terzi, Nicolas, Thakur, Anand, Theerawit, Pongdhep, Thille, Arnaud W, Thomas, Matt, Thungtitigul, Poungrat, Thyrault, Martial, Tilouch, Nejla, Timenetsky, Karina, Tirapu, Juna, Todeschini, Manuel, Tomas, Roser, Tomaszewski, Christian, Tonetti, Tommaso, Tonnelier, Alexandre, Trinder, John, Trongtrakul, Konlawij, Truwit, Jonathon, Tsuei, Betty, Tulaimat, Aiman, Turan, Sema, Turkoglu, Melda, Tyagi, Sanjeev, Ubeda, Alejandro, Vagginelli, Federica, Valenti, María Florencia, Vallverdu, Imma, Van Axel, Alisha, van den Hul, Ingrid, van der Hoeven, Hans, Van Der Meer, Nardo, Vanhoof, Marc, Vargas-Ordoñez, Mónica, Vaschetto, Rosanna, Vascotto, Ettore, Vatsik, Maria, Vaz, Ana, Vazquez-Sanchez, Antonia, Ventura, Sara, Vermeijden, Jan Wytze, Vidal, Anxela, Vieira, Jocyelle, Vilela Costa Pinto, Bruno, Villagra, Ana, Villegas Succar, Cristina, Vinorum, Ole Georg, Vitale, Giovanni, Vj, Ramesh, Vochin, Ana, Voiriot, Guillaume, Volta, Carlo Alberto, von Seth, Magnus, Wajdi, Maazouzi, Walsh, Don, Wang, Shouhong, Wardi, Gabriel, Ween-Velken, Nils Christian, Wei, Bi-Lin, Weller, Dolf, Welsh, Deborah, Welters, Ingeborg, Wert, Michael, Whiteley, Simon, Wilby, Elizabeth, Williams, Erin, Williams, Karen, Wilson, Antoinette, Wojtas, Jadwiga, Won Huh, Jin, Wrathall, David, Wright, Christopher, Wu, Jian-Feng, Xi, Guo, Xing, Zheng-Jiang, Xu, Hongyang, Yamamoto, Kotaro, Yan, Jie, Yáñez, Julio, Yang, Xiaobo, Yates, Elliot, Yazicioglu Mocin, Ozlem, Ye, Zhenglong, Yildirim, Fatma, Yoshida, Norifumi, Yoshido, Hector Higo Leon, Young Lee, Bo, Yu, Rongguo, Yu, Gong, Yu, Tao, Yuan, Boyun, Yuangtrakul, Nadwipa, Yumoto, Tetsuya, Yun, Xie, Zakalik, Graciela, Zaki, Ahmad, Zalba-Etayo, Begoña, Zambon, Massimo, Zang, Bin, Zani, Gianluca, Zarka, Jonathan, Zerbi, Simone Maria, Zerman, Avsar, Zetterquist, Harald, Zhang, Jiuzhi, Zhang, Hongwen, Zhang, Wei, Zhang, Guoxiu, Zhang, Weixin, Zhao, Hongsheng, Zheng, Jia, Zhu, Bin, Zumaran, Ronald, Pham, Tài, Madotto, Fabiana, Goligher, Ewan C, Mancebo, Jordi, Peñuelas, Oscar, Pesenti, Antonio, Wunsch, Hannah, van Haren, Frank, and Laffey, John G

Published
2023
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65. Linguoaxiological Analysis of Kalmyk Proverbs and Sayings with Food-Related Components: A Perspective from European Paremiological Contexts

Author

Natalia Yu. Neliubova, Natalia M. Dugalich, Olga A. Kadilina, and Choduraa Sh. Kol

Subjects
kalmyk paroemias, european paremiological contexts, russian paroemias, french paroemias, linguoaxiological potential of paremias, food-related component of paroemias, dictionary of proverbs and sayings, linguoaxiological analysis, linguistic means of expressing evaluativity, History (General), D1-2009, Oriental languages and literatures, PJ
Abstract

Introduction. The article presents an analysis of Kalmyk food-related proverbs and sayings — comparing the latter to paremiological units of European languages from an axiological perspective. Goals. The study attempts a linguoaxiological analysis of Kalmyk proverbs with gastronomic components and compares them to Russian and French paremiological units. Materials and methods. The paper focuses on a database of paroemias selected via continuous sampling from a variety of dictionaries. The author’s database contains a total of 1,500 paroemias, 260 units have been used in a detailed linguoaxiological analysis, and the article publishes ca. 60 most representative examples. The work employs a complex methodology which includes the steps as follows: to compile an individual cluster of paroemias with gastronomic components for each language; calculate a frequency of gastronomic components and semantically relate the latter to values; characterize emotional and evaluative language means instrumental in correlating gastronomic images with the axiological meaning of a paroemia; analyze Kalmyk paroemias against Russian and French ones via the comparative method. Results. The analysis of paroemias with food components of the three not that closely related languages has showed their high axiological potential. The most frequent components tend to reflect peculiarities of lifestyles and traditions once adopted by the investigated ethnic groups. The material of the three languages is indicative of some correlations within the following values (value dyads): life, knowledge, faith and religion, wealth – poverty. Despite the evident typological differences, the means of expressing evaluativity and their role in creating axiological meanings of paroemias in the three languages have a number of similarities. Conclusions. Such insights into the culturally significant food component in paroemias of Asian and European languages are indicative enough when it comes to investigate the functioning of ethnic value systems, including in terms of their cultural orientations, such as actual degrees of trends towards sociocentrism, primary orientations towards spiritual or material values.

Published
2023
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67. Inflammatory cytokines directly disrupt the bovine intestinal epithelial barrier

Author

Crawford, Charles K, Lopez Cervantes, Veronica, Quilici, Mary L, Armién, Aníbal G, Questa, María, Matloob, Muhammad S, Huynh, Leon D, Beltran, Aeelin, Karchemskiy, Sophie J, Crakes, Katti R, and Kol, Amir

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Digestive Diseases, Prevention, 2.1 Biological and endogenous factors, Aetiology, Animals, Cattle, Cytokines, Dextrans, Epithelial Cells, Interleukin-18, Intestinal Diseases, Intestinal Mucosa, Permeability, Tight Junctions, Tumor Necrosis Factor-alpha
Abstract

The small intestinal mucosa constitutes a physical barrier separating the gut lumen from sterile internal tissues. Junctional complexes between cells regulate transport across the barrier, preventing water loss and the entry of noxious molecules or pathogens. Inflammatory diseases in cattle disrupt this barrier; nonetheless, mechanisms of barrier disruption in cattle are poorly understood. We investigated the direct effects of three inflammatory cytokines, TNFα, IFNγ, and IL-18, on the bovine intestinal barrier utilizing intestinal organoids. Flux of fluorescein isothiocyanate (FITC)-labeled dextran was used to investigate barrier permeability. Immunocytochemistry and transmission electron microscopy were used to investigate junctional morphology, specifically tortuosity and length/width, respectively. Immunocytochemistry and flow cytometry was used to investigate cellular turnover via proliferation and apoptosis. Our study shows that 24-h cytokine treatment with TNFα or IFNγ significantly increased dextran permeability and tight junctional tortuosity, and reduced cellular proliferation. TNFα reduced the percentage of G2/M phase cells, and IFNγ treatment increased cell apoptotic rate. IL-18 did not directly induce significant changes to barrier permeability or cellular turnover. Our study concludes that the inflammatory cytokines, TNFα and IFNγ, directly induce intestinal epithelial barrier dysfunction and alter the tight junctional morphology and rate of cellular turnover in bovine intestinal epithelial cells.

Published
2022

68. Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy.

Author

Taechangam, Nopmanee, Kol, Amir, Arzi, Boaz, and Borjesson, Dori L

Subjects
Stromal Cells, Mesenchymal Stem Cells, Animals, Antiviral Agents, Mesenchymal Stem Cell Transplantation, Immunomodulation, Antiviral immunity, Mesenchymal stem cell, Multipotent stromal cells, Viral disease, Virus interaction, Infectious Diseases, Regenerative Medicine, Stem Cell Research, Biotechnology, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Infection, Inflammatory and immune system, Good Health and Well Being
Abstract

Multipotent stromal cells (MSCs) are widely utilized in therapy for their immunomodulatory properties, but their usage in infectious viral diseases is less explored. This review aimed to collate the current novel use of MSCs in virus-associated conditions, including MSC's susceptibility to virus infection, antiviral properties of MSCs and their effects on cell-based immune response and implementation of MSC therapy in animal models and human clinical trials of viral diseases. Recent discoveries shed lights on MSC's capability in suppressing viral replication and augmenting clearance through enhancement of antiviral immunity. MSC therapy may maintain a crucial balance between aiding pathogen clearance and suppressing hyperactive immune response.

Published
2022

69. Near-Optimal Two-Pass Streaming Algorithm for Sampling Random Walks over Directed Graphs

Author

Chen, Lijie, Kol, Gillat, Paramonov, Dmitry, Saxena, Raghuvansh, Song, Zhao, and Yu, Huacheng

Subjects
Computer Science - Data Structures and Algorithms, Computer Science - Computational Complexity
Abstract

For a directed graph $G$ with $n$ vertices and a start vertex $u_{\sf start}$, we wish to (approximately) sample an $L$-step random walk over $G$ starting from $u_{\sf start}$ with minimum space using an algorithm that only makes few passes over the edges of the graph. This problem found many applications, for instance, in approximating the PageRank of a webpage. If only a single pass is allowed, the space complexity of this problem was shown to be $\tilde{\Theta}(n \cdot L)$. Prior to our work, a better space complexity was only known with $\tilde{O}(\sqrt{L})$ passes. We settle the space complexity of this random walk simulation problem for two-pass streaming algorithms, showing that it is $\tilde{\Theta}(n \cdot \sqrt{L})$, by giving almost matching upper and lower bounds. Our lower bound argument extends to every constant number of passes $p$, and shows that any $p$-pass algorithm for this problem uses $\tilde{\Omega}(n \cdot L^{1/p})$ space. In addition, we show a similar $\tilde{\Theta}(n \cdot \sqrt{L})$ bound on the space complexity of any algorithm (with any number of passes) for the related problem of sampling an $L$-step random walk from every vertex in the graph.

Published
2021

70. Pathology in Practice.

Author

Alonso, Flavio H, Choi, Eunju, Borchers, Angela, Darling, Samantha L, Vasilatis, Demitria, and Kol, Amir

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Animals, Humans, Pathology, Veterinary, United States, Veterinarians, Veterinary sciences
Abstract

In collaboration with the American College of Veterinary Pathologists.

Published
2021

71. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis

Author

Vaara, Suvi T., Serpa Neto, Ary, Bellomo, Rinaldo, Adhikari, Neill K. J., Dreyfuss, Didier, Gallagher, Martin, Gaudry, Stephane, Hoste, Eric, Joannidis, Michael, Pettilä, Ville, Wang, Amanda Y., Kashani, Kianoush, Wald, Ron, Bagshaw, Sean M., Ostermann, Marlies, Bagshaw, Sean M, Wald, Ron, Adhikari, Neill K.J., Bellomo, Rinaldo, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P., Gaudry, Stéphane, Hoste, Eric A., Lamontagne, François, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Nichol, Alistair D., Ostermann, Marlies, Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi T., Weir, Matthew, Bellomo, Rinaldo, Eastwood, Glenn M., Peck, Leah, Young, Helen, Kruger, Peter, Laurie, Gordon, Saylor, Emma, Meyer, Jason, Venz, Ellen, Wetzig, Krista, French, Craig, McGain, Forbes, Mulder, John, Fennessy, Gerard, Koottayi, Sathyajith, Bates, Samantha, Towns, Miriam, Morgan, Rebecca, Tippett, Anna, Udy, Andrew, Mason, Chris, Licari, Elisa, Gantner, Dashiell, McClure, Jason, Nichol, Alistair, McCracken, Phoebe, Board, Jasmin, Martin, Emma, Vallance, Shirley, Young, Meredith, Vladic, Chelsey, McGloughlin, Steve, Gattas, David, Buhr, Heidi, Coles, Jennifer, Hutch, Debra, Wun, James, Cole, Louise, Whitehead, Christina, Lowrey, Julie, Masters, Kristy, Gresham, Rebecca, Campbell, Victoria, Gutierrez, David, Brailsford, Jane, Forbes, Loretta, Murray, Lauren, Maguire, Teena, NiChonghaile, Martina, Orford, Neil, Bone, Allison, Elderkin, Tania, Salerno, Tania, Chimunda, Tim, Fletcher, Jason, Broadfield, Emma, Porwal, Sanjay, Knott, Cameron, Boschert, Catherine, Smith, Julie, Richardson, Angus, Hill, Dianne, Duke, Graeme, Oziemski, Peter, Cegarra, Santiago, Chan, Peter, Welsh, Deborah, Hunter, Stephanie, Roodenburg, Owen, Dyett, John, Kokotsis, Nicos, Moser, Max, Yang, Yang, Padayachee, Laven, Vetro, Joseph, Gangopadhyay, Himangsu, Kaufman, Melissa, Ghosh, Angaj, Said, Simone, Patel, Alpesh, Bihari, Shailesh, Matheson, Elisha, Jin, Xia, Shrestha, Tapaswi, Schwartz, Kate, Gallagher, Martin P., Cross, Rosalba, Cheung, Winston, Wong, Helen, Kol, Mark, Shah, Asim, Wang, Amanda Y., Endre, Zoltan, Bradford, Celia, Janin, Pierre, Finfer, Simon, Diel, Naomi, Gatward, Jonathan, Hammond, Naomi, Delaney, Anthony, Bass, Frances, Yarad, Elizabeth, Buscher, Hergen, Reynolds, Claire, Baker, Nerilee, Joannidis, Michael, Bellmann, Romuald, Peer, Andreas, Hasslacher, Julia, Koglberger, Paul, Klein, Sebastian, Zotter, Klemens, Brandtner, Anna, Finkenstedt, Armin, Ditlbacher, Adelheid, Hartig, Frank, Fries, Dietmar, Bachler, Mirjam, Schenk, Bettina, Wagner, Martin, Staudinger, Thomas, Tiller, Esther, Schellongowski, Peter, Bojic, Andja, Hoste, Eric A., Bracke, Stephanie, De Crop, Luc, Vermeiren, Daisy, Thome, Fernando, Chiella, Bianca, Fendt, Lucia, Antunes, Veronica, Maisonneuve-Rosemont, Lafrance, Jean-Philippe, Lamontagne, François, D’Aragon, Frédérick, St-Arnaud, Charles, Mayette, Michael, Carbonnaeu, Élaine, Marchand, Joannie, Masse, Marie-Hélène, Ladouceur, Marilène, Turgeon, Alexis F., Lauzier, François, Bellemare, David, Langis Francoeur, Charles, LeBlanc, Guillaume, Guilbault, Gabrielle, Grenier, Stéphanie, Cloutier, Eve, Boivin, Annick, Delisle-Thibault, Charles, Giannakouros, Panagiota, Costerousse, Olivier, Cailhier, Jean-François, Carrier, François-Martin, Ghamraoui, Ali, Lebrasseur, Martine, Benettaib, Fatna, Salamé, Maya, Boumahni, Dounia, Tung Sia, Ying, Naud, Jean-François, Roy, Isabelle, Stelfox, Henry T., Ruddell, Stacey, Manns, Braden J., Duggan, Shelley, Carney, Dominic, Barchard, Jennifer, Whitlock, Richard P., Belley-Cote, Emilie, Savija, Nevena, Sabev, Alexandra, Campbell, Troy, Creary, Thais, Devereaux, Kelson, Brodutch, Shira, Rigatto, Claudio, Paunovic, Bojan, Mooney, Owen, Glybina, Anna, Harasemiw, Oksana, Di Nella, Michelle, Harmon, John, Mehta, Navdeep, Lakatos, Louis, Haslam, Nicole, Lellouche, Francois, Simon, Mathieu, Tung, Ying, Lizotte, Patricia, Bourchard, Pierre-Alexandre, Rochwerg, Bram, Karachi, Tim, Millen, Tina, Muscedere, John, Maslove, David, Gordon Boyd, J., Sibley, Stephanie, Drover, John, Hunt, Miranda, Georgescu, Ilinca, Wax, Randy, Lenga, Ilan, Sridhar, Kavita, Steele, Andrew, Fusco, Kelly, Ghate, Taneera, Tolibas, Michael, Robinson, Holly, Weir, Matthew A., Taneja, Ravi, Ball, Ian M., Garg, Amit, Campbell, Eileen, Ovsenek, Athena, Bagshaw, Sean M., van Diepen, Sean, Baig, Nadia, Magder, Sheldon, Yao, Han, Alam, Ahsan, Campisi, Josie, MacIntyre, Erika, Rokosh, Ella, Scherr, Kimberly, Lapinsky, Stephen, Mehta, Sangeeta, Shah, Sumesh, Niven, Daniel J., Stelfox, Henry T., Ruddell, Stacey, Russell, Michael, Jim, Kym, Brown, Gillian, Oxtoby, Kerry, Hall, Adam, Benoit, Luc, Sokolowski, Colleen, Prasad, Bhanu, Rao, Jag, Giebel, Shelley, Kutsogiannis, Demetrios J., Thompson, Patricia, Thompson, Tayne, Cirone, Robert, Kavikondala, Kanthi, Soth, Mark, Clarke, France, Takaoka, Alyson, Wald, Ron, Mazer, David, Burns, Karen, Friedrich, Jan, Klein, David, Sandhu, Gyan, Santos, Marlene, Khalid, Imrana, Hodder, Jennifer, Dodek, Peter, Ayas, Najib, Alcuaz, Victoria, Suen, Gabriel, Rewa, Oleksa, Singh, Gurmeet, Norris, Sean, Gibson, Neil, Arias, Castro, Shami, Aysha, Pelletier, Celine, Adhikari, Neill K.J., Zahirieh, Alireza, Amaral, Andre, Marinoff, Nicole, Kaur, Navjot, Perez, Adic, Wang, Jane, Haljan, Gregory, Condin, Christopher, McIntyre, Lauralyn, Gomes, Brigette, Porteous, Rebecca, Watpool, Irene, Hiremath, Swapnil, Clark, Edward, Herridge, Margaret S., Backhouse, Felicity, Elizabeth Wilcox, M., Walczak, Karolina, Ki, Vincent, Sharman, Asheer, Romano, Martin, Bagshaw, Sean M., Noel Gibney, R.T., Romanovsky, Adam S., Rewa, Oleksa, McCoshen, Lorena, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Duan, Meili, Ji, Xiaojun, Guo, Dongchen, Qi, Zhili, Lin, Jin, Zhang, Meng, Dong, Lei, Liu, Jingfeng, Liu, Pei, Zhi, Deyuan, Bai, Guoqiang, Qiu, Yu, Yang, Ziqi, Bai, Jing, Liu, Zhuang, Zhuang, Haizhou, Wang, Haiman, Li, Jian, Zhao, Mengya, Zhou, Xiao, Shi, Xianqing, Ye, Baning, Liu, Manli, Wu, Jing, Fu, Yongjian, Long, Dali, Pan, Yu, Wang, Jinlong, Mei, Huaxian, Zhang, Songsong, Wen, Mingxiang, Yang, Enyu, Mu, Sijie, Li, Jianquan, Hu, Tingting, Qin, Bingyu, Li, Min, Wang, Cunzhen, Dong, Xin, Wang, Kaiwu, Wang, Haibo, Yang, Jianxu, Du, Bin, Wang, Chuanyao, Wang, Dongxin, Li, Nan, Yu, Zhui, Xu, Song, Yao, Lan, Hou, Guo, Liu, Zhou, Lu, Liping, Lian, Yingtao, Wang, Chunting, Zhang, Jichen, Ding, Ruiqi, Qi, Guoqing, Wang, Qizhi, Wang, Peng, Meng, Zhaoli, Chen, Man, Hu, Xiaobo, He, Xiandi, Zhao, Shibing, Hang, Lele, Li, Rui, Qin, Suhui, Lu, Kun, Dun, Shijuan, Liu, Cheng, Zhou, Qi, Chen, Zhenzhen, Mei, Jing, Zhang, Minwei, Xu, Hao, Lin, Jincan, Shi, Qindong, Fu, Lijuan, Zeng, Qinjing, Ma, Hongye, Yan, Jinqi, Gao, Lan, Liu, Hongjuan, Zhang, Lei, Li, Hao, He, Xiaona, Fan, Jingqun, Guo, Litao, Liu, Yu, Wang, Xue, Sun, Jingjing, Liu, Zhongmin, Yang, Juan, Ding, Lili, Sheng, Lulu, Liu, Xingang, Yan, Jie, Wang, Quihui, Wang, Yifeng, Zhao, Dan, Zhao, Shuangping, Hu, Chenghuan, Li, Jing, Deng, Fuxing, Qiu, Haibo, Yang, Yi, Mo, Min, Pan, Chun, Wu, Changde, Huang, Yingzi, Huang, Lili, Liu, Airan, Pettilä, Ville, Vaara, Suvi T., Korhonen, Anna-Maija, Törnblom, Sanna, Sutinen, Sari, Pettilä, Leena, Heinonen, Jonna, Lappi, Eliria, Suhonen, Taria, Karlsson, Sari, Hoppu, Sanna, Jalkanen, Ville, Kuitunen, Anne, Levoranta, Markus, Långsjö, Jaakko, Ristimäki, Sanna, Malila, Kaisa, Wootten, Anna, Varila, Simo, Järvisalo, Mikko J, Inkinen, Outi, Kentala, Satu, Leivo, Keijo, Haltia, Paivi, Dreyfuss, Didier, Ricard, Jean-Damien, Messika, Jonathan, Tiagarajah, Abirami, Emery, Malo, Dechanet, Aline, Gernez, Coralie, Roux, Damien, Martin-Lefevre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Claude Lacherade, Jean, Colin, Gwenhaël, Lebert, Christine, Azais, Marie-Ange, Yehia, Aihem, Pouplet, Caroline, Henry- Lagarrigue, Matthieu, Seguin, Amélie, Crosby, Laura, Maizel, Julien, Titeca-Beauport, Dimitri, Combes, Alain, Nieszkowska, Ania, Masi, Paul, Demoule, Alexandre, Mayaux, Julien, Dres, Martin, Morawiec, Elise, Decalvele, Maxens, Demiri, Suela, Faure, Morgane, Marios, Clémence, Mallet, Maxime, Amélie Ordon, Marie, Morizot, Laura, Cantien, Marie, Pousset, François, Gaudry, Stéphane, Poirson, Florent, Cohen, Yves, Argaud, Laurent, Cour, Martin, Bitker, Laurent, Simon, Marie, Hernu, Romain, Baudry, Thomas, De La Salle, Sylvie, Robine, Adrien, Sedillot, Nicholas, Tchenio, Xavier, Bouisse, Camille, Roux, Sylvie, Barbar, Davide, Trusson, Rémi, Tamion, Fabienne, Grangé, Steven, Carpentier, Dorothée, Chevrel, Guillaume, Ensenyat-Martin, Luis, Marque, Sophie, Quenot, Jean-Pierre, Andreu, Pascal, Dargent, Auguste, Large, Audrey, Chudeau, Nicolas, Landais, Mickael, Derrien, Benoit, Christophe Callahan, Jean, Guitton, Christophe, Le Moal, Charlène, Robert, Alain, Asehnoune, Karim, Cinotti, Raphaël, Grillot, Nicolas, Demeure, Dominique, Vinsonneau, Christophe, Rahmani, Imen, Marzouk, Mehdi, Dekeyser, Thibault, Sejourne, Caroline, Verlay, Mélanie, Thevenin, Fabienne, Delecolle, Lucie, Didier Thevenin, Lens, Souweine, Bertrand, Coupez, Elisabeth, Adda, Mireille, Eraldi, Jean-Pierre, Marchalot, Antoine, De Prost, Nicolas, Mekontso Dessap, Armand, Razazi, Keyvan, Meziani, Ferhat, Boisrame-Helms, Julie, Clere-Jehl, Raphael, Delabranche, Xavier, Kummerlen, Christine, Merdji, Hamid, Monnier, Alexandra, Rabouel, Yannick, Rahmani, Hassene, Allam, Hayat, Chenaf, Samir, Franja, Vincenta, Pons, Bertrand, Carles, Michel, Martino, Frédéric, Richard, Régine, Zuber, Benjamin, Lacave, Guillaume, Lakhal, Karim, Rozec, Bertrand, Dang Van, Hoa, Boulet, Éric, Dubos, René, Fadel, Fouad, Cleophax, Cedric, Dufour, Nicolas, Grant, Caroline, Thuong, Marie, Reignier, Jean, Canet, Emmanuel, Nicolet, Laurent, Boulain, Thierry, Nay, Mai-Anh, Benzekri, Dalila, Barbier, François, Bretagnol, Anne, Kamel, Toufik, Mathonnet, Armelle, Muller, Grégoire, Skarzynski, Marie, Rossi, Julie, Pradet, Amandine, Dos Santos, Sandra, Guery, Aurore, Muller, Lucie, Felix, Luis, Bohé, Julien, Thiéry, Guillaume, Aissaoui, Nadia, Vimpere, Damien, Commeureuc, Morgane, Diehl, Jean-Luc, Guerot, Emmanuel, Liangos, Orfeas, Wittig, Monika, Zarbock, Alexander, Küllmar, Mira, van Waegeningh, Thomas, Rosenow, Nadine, Nichol, Alistair D., Brickell, Kathy, Doran, Peter, Murray, Patrick T., Landoni, Giovanni, Lembo, Rosalba, Zangrillo, Alberto, Monti, Giacomo, Tozzi, Margherita, Marzaroli, Matteo, Lombardi, Gaetano, Paternoster, Gianluca, Vitiello, Michelangelo, McGuinness, Shay, Parke, Rachael, Butler, Magdalena, Gilder, Eileen, Cowdrey, Keri-Anne, Wallace, Samantha, Hallion, Jane, Woolett, Melissa, Neal, Philippa, Duffy, Karina, Long, Stephanie, McArthur, Colin, Simmonds, Catherine, Chen, Yan, McConnochie, Rachael, Newby, Lynette, Knight, David, Henderson, Seton, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Vander Hayden, Kymbalee, Burke, Tara, Bailey, Matthew, Freebairn, Ross, Chadwick, Lesley, Park, Penelope, Rolls, Christine, Thomas, Liz, Buehner, Ulrike, Williams, Erin, Albrett, Jonathan, Kirkham, Simon, Jackson, Carolyn, Browne, Troy, Goodson, Jennifer, Jackson, David, Houghton, James, Callender, Owen, Higson, Vicki, Keet, Owen, Dominy, Clive, Young, Paul, Hunt, Anna, Judd, Harriet, Lawrence, Cassie, Olatunji, Shaanti, Robertson, Yvonne, Latimer-Bell, Charlotte, Hendry, Deborah, Mckay-Vucago, Agnes, Beehre, Nina, Lesona, Eden, Navarra, Leanlove, Robinson, Chelsea, Jang, Ryan, Junge, Andrea, Lambert, Bridget, Schneider, Antoine G., Thibault, Michel, Eckert, Philippe, Kissling, Sébastien, Polychronopoulos, Erietta, Poli, Elettra, Altarelli, Marco, Schnorf, Madeleine, Abed Mallaird, Samia, Heidegger, Claudia, Perret, Aurelie, Montillier, Philippe, Sangla, Frederic, Neils, Seigenthaller, De Watteville, Aude, Phull, Mandeep-Kaur, George, Aparna, Hussain, Nauman, Pogreban, Tatiana, Lobaz, Steve, Daniels, Alison, Cunningham, Mishell, Kerr, Deborah, Nicholson, Alice, Shanmugasundaram, Pradeep, Abrams, Judith, Manso, Katarina, Hambrook, Geraldine, McKerrow, Elizabeth, Salva, Juvy, Foulkes, Stephen, Wise, Matthew, Morgan, Matt, Brooks, Jenny, Cole, Jade, Michelle Davies, Tracy, Hill, Helen, Thomas, Emma, Vizcaychipi, Marcela, Baharlo, Behrad, Carungcong, Jaime, Costa, Patricia, Martins, Laura, Kapoor, Ritoo, Hazelton, Tracy, Moon, Angela, Musselwhite, Janine, Shelley, Ben, McCall, Philip, Ostermann, Marlies, Arbane, Gill, Bociek, Aneta, Marotti, Martina, Lim, Rosario, Campos, Sara, Grau Novellas, Neus, Cennamo, Armando, Slack, Andrew, Wyncoll, Duncan, Camporota, Luigi, Sparkes, Simon, Tilley, Rosalinde, Rattray, Austin, Moreland, Gayle, Duffy, Jane, McGonigal, Elizabeth, Hopkins, Philip, Finney, Clare, Smith, John, Noble, Harriet, Watson, Hayley, Harris, Claire-Louise, Clarey, Emma, Corcoran, Eleanor, Beck, James, Howcroft, Clare, Youngs, Nora, Wilby, Elizabeth, Ogg, Bethan, Wolverson, Adam, Lee, Sandra, Butler, Susie, Okubanjo, Maryanne, Hindle, Julia, Welters, Ingeborg, Williams, Karen, Johnson, Emily, Patrick-Heselton, Julie, Shaw, David, Waugh, Victoria, Stewart, Richard, Mwaura, Esther, Wren, Lynn, Mew, Louise, Sutherland, Sara-Beth, Adderley, Jane, Ruddy, Jim, Harkins, Margaret, Kaye, Callum, Scott, Teresa, Mitchell, Wendy, Anderson, Felicity, Willox, Fiona, Jagannathan, Vijay, Clark, Michele, Purv, Sarah, Sharman, Andrew, Meredith, Megan, Ryan, Lucy, Conner, Louise, Peters, Cecilia, Harvey, Dan, Roshdy, Ashraf, Collins, Amy, Sim, Malcolm, Henderson, Steven, Chee, Nigel, Pitts, Sally, Bowman, Katie, Dilawershah, Maria, Vamplew, Luke, Howe, Elizabeth, Rogers, Paula, Hernandez, Clara, Prendergast, Clara, Benton, Jane, Rosenberg, Alex, Forni, Lui G., Grant, Alice, Carvelli, Paula, Raithatha, Ajay, Bird, Sarah, Richardson, Max, Needham, Matthew, Hirst, Claire, Ball, Jonathan, Leaver, Susannah, Howlett, Luisa, Castro Delgado, Carlos, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Joseph, Gipsy, Robinson, Francesca, Tridente, Ascanio, Harrop, Clare, Shuker, Karen, McLaughlan, Derek, Ramsey, Judith, Meehan, Sharon, Oliver Rose, Bernd, Reece-Anthony, Rosie, Gurung, Babita, Whitehouse, Tony, Snelson, Catherine, Veenith, Tonny, Johnston, Andy, Cooper, Lauren, Carrera, Ron, Ellis, Karen, Fellows, Emma, Harkett, Samanth, Bergin, Colin, Spruce, Elaine, Despy, Liesl, Goundry, Stephanie, Dooley, Natalie, Mason, Tracy, Clark, Amy, Dignam, Gemma, Ward, Geraldine, Attwood, Ben, Parsons, Penny, Mason, Sophie, Margarson, Michael, Lord, Jenny, McGlone, Philip, Hodgson, Luke E., Chadbourn, Indra, Gomez, Raquel, Margalef, Jordi, Pretorius, Rinus, Hamshere, Alexandra, Carter, Joseph, Cahill, Hazel, Grainger, Lia, Howard, Kate, Forshaw, Greg, Guy, Zoe, Kashani, Kianoush B., Albright, Robert C., Amsbaugh, Amy, Stoltenberg, Anita, Niven, Alexander S., Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Tolwani, Ashita, Lyas, Claretha, Latta, Laura, Bihorac, Azra, Hashemighouchani, Haleh, Efron, Philip, Ruppert, Matthew, Cupka, Julie, Kiley, Sean, Carson, Joshua, White, Peggy, Omalay, George, Brown, Sherry, Velez, Laura, Marceron, Alina, Neyra, Javier A., Carlos Aycinena, Juan, Elias, Madona, Ortiz-Soriano, Victor M., Hauschild, Caroline, and Dorfman, Robert

Published
2024
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72. Testing the Flux-based statistical prediction of the Three-Body Problem

Author

Manwadkar, Viraj, Kol, Barak, Trani, Alessandro A., and Leigh, Nathan W. C.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Nonlinear Sciences - Chaotic Dynamics
Abstract

We present an extensive comparison between the statistical properties of non-hierarchical three-body systems and the corresponding three-body theoretical predictions. We perform and analyze 1 million realizations for each different initial condition considering equal and unequal mass three-body systems to provide high accuracy statistics. We measure 4 quantities characterizing the statistical distribution of ergodic disintegrations: escape probability of each body, the characteristic exponent for escapes by a narrow margin, predicted absorptivity as a function of binary energy and binary angular momentum, and, finally, the lifetime distribution. The escape probabilities are shown to be in agreement down to the 1% level with the emissivity-blind, flux-based theoretical prediction. This represents a leap in accuracy compared to previous three-body statistical theories. The characteristic exponent at the threshold for marginally unbound escapes is an emissivity-independent flux-based prediction, and the measured values are found to agree well with the prediction. We interpret both tests as strong evidence for the flux-based three-body statistical formalism. The predicted absorptivity and lifetime distributions are measured to enable future tests of statistical theories., Comment: 17 pages, 11 figures

Published
2021
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74. Subleading BMS Charges and The Lorentz Group

Author

Kol, Uri

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology, Mathematical Physics
Abstract

The extended BMS group includes supertranslation, dual supertranslation and Lorentz transformations. The generators of these symmetries can be classified according to their parity into "electric" and "magnetic" types. Using a multipole expansion of gravitational sources in the Newman-Penrose formalism, we associate each one of these charges with a particular moment. At leading order, the "electric" and "magnetic" monopole moments correspond respectively to supertranslations and dual supertranslations. At the first subleading order, the "electric" and "magnetic" dipole moments correspond respectively to boosts and rotations, therefore comprising the entire Lorentz group. Electric-magnetic type of duality then rotates the boost and rotation generators into each other., Comment: v2: references added

Published
2020

82. Multi-objective Optimization Using the Simulation of Net-Zero Energy Residential Buildings with the African Vulture Optimizer

Author

Kol Tapeh, Ghadir Ghasemi, Gholinia, Fatemeh, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Razmjooy, Navid, editor, Ghadimi, Noradin, editor, and Rajinikanth, Venkatesan, editor

Published
2023
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85. Thermal Conductivity Temperature Dependence of Heat-treated Wood at Different Moisture Content Levels

Author

Hamiyet Şahin Kol and Kübra Gündüz Vaydoğan

Subjects
thermal conductivity, heat treatment, moisture content, pine, beech wood, Biotechnology, TP248.13-248.65
Abstract

Effects of temperature dependence and relative humidity were studied relative to the thermal conductivity of heat-treated pine and heat-treated beech, which are frequently used for building construction. Pine and beech wood were exposed to heat treatment at 180, 200, and 220 °C in nitrogen gas for 2 h. As a result, the thermal conductivity values of the heat-treated wood decreased as the temperature of the heat treatment process increased and relative humidity increased. However, thermal conductivity of wood became more stable after heat treatment under relative humidity changes. The thermal conductivity values increased with rising mean plate temperatures, while the temperature dependence of the heat-treated wood was not affected by the relative humidity changes. Consequently, heat-treated wood, with variable humidity without excessive heat changes, can be preferred for the construction of buildings.

Published
2023

86. MANEJO DA ANSIEDADE EM ADOLESCENTES: REVISÃO DE LITERATURA

Author

BEZERRA KOL, THAÍS, primary, KARINE LÚCIO ALVES, DANIELLE, additional, FEDOZI TONON, AMANDA, additional, QUEIROZ GONÇALVES, THALLYA, additional, BUENO DE CAMARGO, BIANCA, additional, MAISA SOARES VIEIRA, JUNIA, additional, APARECIDA LIMA BRANDÃO, ALINE, additional, CRISTINA ROSCAMP MARTINS, VANEZA, additional, CAMILO DE BRITO BADARO CAMPOS, CARMECI, additional, and CRISTINA DA FONSECA, ELAINE, additional

Published
2023
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87. Dual Komar Mass, Torsion and Riemann-Cartan Manifolds

Author

Kol, Uri

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology, Mathematical Physics
Abstract

The dual Komar mass generalizes the concept of the NUT parameter and is akin to the magnetic charge in electrodynamics. In asymptotically flat spacetimes it coincides with the dual supertranslation charge. The dual mass vanishes identically on Riemannian manifolds in General Relativity unless conical singularities corresponding to Misner strings are introduced. In this paper we propose an alternative way to source the dual mass locally. We show that this can be done by enlarging the phase space of the theory to allow for a violation of the algebraic Bianchi identity using local fields. A minimal extension of Einstein's gravity that meets this requirement is known as the Einstein-Cartan theory. Our main result is that on Riemann-Cartan manifolds the dual Komar mass does not vanish and is given by a volume integral over a local 1-form gravitational-magnetic current that is a function of the torsion.

Published
2020

88. Amplitudes from Coulomb to Kerr-Taub-NUT

Author

Emond, William T., Huang, Yu-tin, Kol, Uri, Moynihan, Nathan, and O'Connell, Donal

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology
Abstract

Electric-magnetic duality, the Newman-Janis shift, and the double copy all act by elementary operations on three-point amplitudes. At the same time, they generate a network of interesting classical solutions spanning from the Coulomb charge via the dyon to the Kerr-Taub-NUT spacetime. We identify the amplitudes corresponding to each of these solutions, working to all orders in spin, but to leading perturbative order. We confirm that the amplitudes double-copy when the solutions are related by the classical double copy. Along the way we show that the Kerr-Taub-NUT solution corresponds to a gravitational electric-magnetic duality rotation acting on the Kerr solution, again to all orders in spin, and demonstrate that the asymptotic charges also transform simply under our operations., Comment: 35 pages + appendices, 2 figures. Mathematica notebook attached

Published
2020

89. Numerator Seagull and Extended Symmetries of Feynman Integrals

Author

Kol, Barak, Schiller, Amit, and Shir, Ruth

Subjects
High Energy Physics - Theory
Abstract

The Symmetries of Feynman Integrals (SFI) method is extended for the first time to incorporate an irreducible numerator. This is done in the context of the so-called vacuum and propagator seagull diagrams, which have 3 and 2 loops, respectively, and both have a single irreducible numerator. For this purpose, an extended version of SFI (xSFI) is developed. For the seagull diagrams with general masses, the SFI equation system is found to extend by two additional equations. The first is a recursion equation in the numerator power, which has an alternative form as a differential equation for the generating function. The second equation applies only to the propagator seagull and does not involve the numerator. We solve the equation system in two cases: over the singular locus and in a certain 3 scale sector where we obtain novel closed-form evaluations and epsilon expansions, thereby extending previous results for the numerator-free case., Comment: 27 pages, 1 figure, v2: added references

Published
2020
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90. Multi-Pass Graph Streaming Lower Bounds for Cycle Counting, MAX-CUT, Matching Size, and Other Problems

Author

Assadi, Sepehr, Kol, Gillat, Saxena, Raghuvansh R., and Yu, Huacheng

Subjects
Computer Science - Data Structures and Algorithms, Computer Science - Computational Complexity
Abstract

Consider the following gap cycle counting problem in the streaming model: The edges of a $2$-regular $n$-vertex graph $G$ are arriving one-by-one in a stream and we are promised that $G$ is a disjoint union of either $k$-cycles or $2k$-cycles for some small $k$; the goal is to distinguish between these two cases. Verbin and Yu [SODA 2011] introduced this problem and showed that any single-pass streaming algorithm solving it requires $n^{1-\Omega(\frac{1}{k})}$ space. This result and the technique behind it -- the Boolean Hidden Hypermatching communication problem -- has since been used extensively for proving streaming lower bounds for various problems. Despite its significance and broad range of applications, the lower bound technique of Verbin and Yu comes with a key weakness that is inherited by all subsequent results: the Boolean Hidden Hypermatching problem is hard only if there is exactly one round of communication and can be solved with logarithmic communication in two rounds. Therefore, all streaming lower bounds derived from this problem only hold for single-pass algorithms. We prove the first multi-pass lower bound for the gap cycle counting problem: Any $p$-pass streaming algorithm that can distinguish between disjoint union of $k$-cycles vs $2k$-cycles -- or even $k$-cycles vs one Hamiltonian cycle -- requires $n^{1-\frac{1}{k^{\Omega(1/p)}}}$ space. As a corollary of this result, we can extend many of previous lower bounds to multi-pass algorithms. For instance, we can now prove that any streaming algorithm that $(1+\epsilon)$-approximates the value of MAX-CUT, maximum matching size, or rank of an $n$-by-$n$ matrix, requires either $n^{\Omega(1)}$ space or $\Omega(\log{(\frac{1}{\epsilon})})$ passes. For all these problems, prior work left open the possibility of even an $O(\log{n})$ space algorithm in only two passes., Comment: Fixed a mistake in one of the technical lemmas, see Section 1.4

Published
2020

91. Gravitational Wu-Yang Monopoles

Author

Kol, Uri and Porrati, Massimo

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology, Mathematical Physics
Abstract

We show that in an asymptotically flat space where an S-Matrix can be defined, dual supertranslations leave all its matrix elements invariant and the Hilbert space of asymptotic states factorizes into distinct super-selection sectors, labeled by their dual supertranslation charges. These results suggest that dual supertranslation may be interpreted as a redundant gauge symmetry of asymptotically flat spacetimes. This would allow to recast general relativity as a theory of diffeomorphisms possessing an additional asymptotic gauge symmetry. We then use the conjectured dual supertranslation gauge symmetry to construct a gravitational equivalent of the Wu-Yang monopole solution. The metric describing the solution is defined using two overlapping patches on the celestial sphere. The solution is regular on each one of the patches separately and differentiable in the overlap region, where the two descriptions are identical by virtue of a dual supertranslation gauge transformation. Our construction provides an alternative to Misner's interpretation of the Taub-NUT metric. In particular, we find that using our approach the Taub-NUT metric can be made regular everywhere on the celestial sphere and at the same time it is devoid of closed timelike curves, provided that the bound $\frac{m}{\ell} \leq \sqrt{\frac{5}{27}}$ on the ratio of mass to NUT charge is obeyed., Comment: 25 pages

Published
2020
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93. Flux-based statistical prediction of three-body outcomes

Author

Kol, Barak

Subjects
General Relativity and Quantum Cosmology, Astrophysics - Earth and Planetary Astrophysics, High Energy Physics - Theory
Abstract

The gravitational three-body problem is a rich open problem, dating back to Newton. It serves as a prototypical example of a chaotic system and has numerous applications in astrophysics. Generically, the motion is non-integrable and susceptible to disintegration, and for negative total energy the decay outcome is a free body flying apart from a binary. Since Poincar\'e, the problem is known to be chaotic and is believed to lack a general deterministic solution. Instead, decades ago a statistical solution was marked as a goal. Yet, despite considerable progress, all extant approaches display two flaws. First, probability was equated with phase space volume, thereby ignoring the fact that significant regions of phase space describe regular motion, including post-decay motion. Secondly and relatedly, an adjustable parameter, the strong interaction region, which is a sort of cutoff, was a central ingredient of the theory. This paper introduces remedies and presents for the first time a statistical prediction of decay rates, in addition to outcomes. Based on an analogy with a particle moving within a leaky container, the statistical distribution is presented in an exactly factorized form. One factor is the flux of phase-space volume, rather than the volume itself, and it is given in a cutoff-independent closed-form. The other factors are the chaotic absorptivity and the regularized phase space volume. The situation is analogous to Kirchhoff's law of thermal radiation, also known as greybody radiation. In addition, an equation system for the time evolution of the statistical distribution is introduced; it describes the decay rate statistics while accounting for sub-escape excursions. Early numerical tests indicate a leap in accuracy., Comment: 32 pages. Version prepared for publication

Published
2020
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94. Development of a flow cytometric panel to assess prognostic biomarkers in fine needle aspirates of canine cutaneous or subcutaneous mast cell tumors

Author

BinXi Wu, Amandine Lejeune, Verena K. Affolter, Giulia Iamone, Fulvio Riondato, and Amir Kol

Subjects
flow cytometry, fine needle aspirate, canine cutaneous mast cell tumor, biomarkers, Ki-67, CD117, Veterinary medicine, SF600-1100
Abstract

Mast cell tumor (MCT) is a common skin cancer in dogs that has a wide range of clinical behaviors. The purpose of this study was to develop a novel multicolor flow cytometry (FC) panel that will enable the quantification of candidate prognostic markers (Ki-67 and pKIT) in fine needle aspirate (FNA) samples prior to surgical removal of the tumors. FNA of canine MCTs and the NI-1 cell line were utilized to develop a FC panel that includes a viability dye (FVS620, BD Biosciences; 7-AAD, Invitrogen) and the following primary conjugated antibodies: CD117-PE (ACK45, BD Biosciences), pKIT-A647 (polyclonal bs-3242R, BIOSS) and Ki-67-FITC (20Raj1, eBioscience; MIB-1, DAKO). A total of nine FNA samples of canine MCTs were collected, seven out which produced sufficient cells for FC analysis. The Ki-67 antibody clone 20Raj1 produced a positive signal when applied to blood leukocytes but failed to provide robust labeling of neoplastic mast cells. The Ki-67 antibody clone MIB-1 delivered a superior staining quality in both the NI-1 cells and primary MCT cells. CD117-PE signal was adequate post fixation and permeabilization and in the combination of 7-AAD. pKIT produced non-specific staining and was not suitable for this multicolor FC panel. In conclusion, FNA samples of canine MCTs can often yield adequate cell numbers for FC analysis, and a multicolor FC panel was developed that can detect Ki-67 in canine mast cells. This would permit further studies into the potential use of this panel for canine cutaneous and subcutaneous MCT prognostication purposes.

Published
2023
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95. Gut germinal center regeneration and enhanced anti-viral immunity by mesenchymal stem/stromal cells in SIV infection

Author

Weber, Mariana G, Walters-Laird, Chara J, Kol, Amir, Rocha, Clarissa Santos, Hirao, Lauren A, Mende, Abigail, Balan, Bipin, Arredondo, Juan, Elizaldi, Sonny R, Iyer, Smita S, Tarantal, Alice, and Dandekar, Satya

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Regenerative Medicine, Prevention, Vaccine Related, Infectious Diseases, Immunization, HIV/AIDS, Vaccine Related (AIDS), Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Infection, Inflammatory and immune system, Good Health and Well Being, Animals, Cytokines, Germinal Center, Immunity, Humoral, Intestinal Mucosa, Macaca mulatta, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Simian Acquired Immunodeficiency Syndrome, Simian Immunodeficiency Virus, Simian immunodeficiency virus, AIDS/HIV, Cellular immune response, Biomedical and clinical sciences, Health sciences
Abstract

Although antiretroviral therapy suppresses HIV replication, it does not eliminate viral reservoirs or restore damaged lymphoid tissue, posing obstacles to HIV eradication. Using the SIV model of AIDS, we investigated the effect of mesenchymal stem/stromal cell (MSC) infusions on gut mucosal recovery, antiviral immunity, and viral suppression and determined associated molecular/metabolic signatures. MSC administration to SIV-infected macaques resulted in viral reduction and heightened virus-specific responses. Marked clearance of SIV-positive cells from gut mucosal effector sites was correlated with robust regeneration of germinal centers, restoration of follicular B cells and T follicular helper (Tfh) cells, and enhanced antigen presentation by viral trapping within the follicular DC network. Gut transcriptomic analyses showed increased antiviral response mediated by pathways of type I/II IFN signaling, viral restriction factors, innate immunity, and B cell proliferation and provided the molecular signature underlying enhanced host immunity. Metabolic analysis revealed strong correlations between B and Tfh cell activation, anti-SIV antibodies, and IL-7 expression with enriched retinol metabolism, which facilitates gut homing of antigen-activated lymphocytes. We identified potentially new MSC functions in modulating antiviral immunity for enhanced viral clearance predominantly through type I/II IFN signaling and B cell signature, providing a road map for multipronged HIV eradication strategies.

Published
2021

96. The Double Copy of Electric-Magnetic Duality

Author

Huang, Yu-tin, Kol, Uri, and O'Connell, Donal

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract

We argue that the complex transformation relating the Schwarzschild to the Taub-NUT metric, introduced by Talbot, is in fact an electric-magnetic duality transformation. We show that at null infinity, the complex transformation is equivalent to a complexified BMS supertranslation, which rotates the supertranslation and the dual (magnetic) supertranslation charges. This can also be seen from the cubic coupling between the classical source and its background, which for Taub-NUT is given by a complex phase rotation acting on gravitational minimal couplings. The same phase rotation generates dyons from electrons at the level of minimally coupled amplitudes, manifesting the double copy relation between the two solutions., Comment: 27 pages, 3 figures. v2: typos corrected, references added

Published
2019
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99. Canine leishmaniasis in Northern California—A case report

Author

Alonso, Flavio H, Vasilatis, Demitria M, Veluvolu, Sridhar M, Willcox, Jennifer L, Scorza, Breanna M, Petersen, Christine A, and Kol, Amir

Subjects
Vector-Borne Diseases, Rare Diseases, Infectious Diseases, Good Health and Well Being, Animals, Dog Diseases, Dogs, Leishmania infantum, Leishmaniasis, Leishmaniasis, Visceral, Real-Time Polymerase Chain Reaction, bone marrow, hyperglobulinemia, Leishmania, protozoan, United States, Zoology, Veterinary Sciences
Abstract

A 3-year-old dog was referred to the Veterinary Medical Teaching Hospital of the University of California-Davis for further evaluation of episodes of epistaxis of 1-year duration and peripheral lymphadenopathy. The patient had a history of atopic dermatitis with no travel history outside of California. Hyperglobulinemia with a polyclonal gammopathy was noted on serum protein electrophoresis. Microscopic evaluation of a bone marrow aspirate sample revealed many free and intra-cellular amastigotes of Leishmania sp. that was further confirmed by qPCR as L infantum. This is, to the best of our knowledge, the first reported case of canine leishmaniasis in the state of California. The patient is believed to have been vertically infected from the dam who is from Serbia and remained subclinical until presentation. Because the clinical progression of leishmaniasis is variable, it is important that precautions be discussed with owners acquiring puppies with dams from endemic regions of leishmaniasis to prevent zoonotic exposure in states where competent vectors are present.

Published
2021

100. Chromatin accessibility in canine stromal cells and its implications for canine somatic cell reprogramming

Author

Questa, Maria, Moshref, Maryam, Jimenez, Robert J, Lopez‐Cervantes, Veronica, Crawford, Charles K, Settles, Matthew L, Ross, Pablo J, and Kol, Amir

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Stem Cell Research - Embryonic - Non-Human, Regenerative Medicine, Human Genome, Stem Cell Research, Genetics, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Biochemistry and Cell Biology, Clinical Sciences, Medical biotechnology, Biomedical engineering
Abstract

Naturally occurring disease in pet dogs is an untapped and unique resource for stem cell-based regenerative medicine translational research, given the many similarities and complexity such disease shares with their human counterparts. Canine-specific regulators of somatic cell reprogramming and pluripotency maintenance are poorly understood. While retroviral delivery of the four Yamanaka factors successfully reprogrammed canine embryonic fibroblasts, adult stromal cells remained resistant to reprogramming in spite of effective viral transduction and transgene expression. We hypothesized that adult stromal cells fail to reprogram due to an epigenetic barrier. Here, we performed assay for transposase-accessible chromatin using sequencing (ATAC-seq) on canine stromal and pluripotent stem cells, analyzing 51 samples in total, and establishing the global landscape of chromatin accessibility before and after reprogramming to induced pluripotent stem cells (iPSC). We also studied adult stromal cells that do not yield iPSC colonies to identify potential reprogramming barriers. ATAC-seq analysis identified distinct cell type clustering patterns and chromatin remodeling during embryonic fibroblast reprogramming. Compared with embryonic fibroblasts, adult stromal cells had a chromatin accessibility landscape that reflects phenotypic differentiation and somatic cell-fate stability. We ultimately identified 76 candidate genes and several transcription factor binding motifs that may be impeding somatic cell reprogramming to iPSC, and could be targeted for inhibition or activation, in order to improve the process in canines. These results provide a vast resource for better understanding of pluripotency regulators in dogs and provide an unbiased rationale for novel canine-specific reprogramming approaches.

Published
2021

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